Page last updated: 2024-08-17

dichloroacetic acid and Acidosis, Lactic

dichloroacetic acid has been researched along with Acidosis, Lactic in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (21.95)	18.7374
1990's	39 (47.56)	18.2507
2000's	17 (20.73)	29.6817
2010's	7 (8.54)	24.3611
2020's	1 (1.22)	2.80

Authors

Authors	Studies
Horne, LP; James, MO; Joseph, S; Keller-Wood, M; Langaee, T; Sharma, A; Stacpoole, PW; Wood, CE	1
Aime, S; Anemone, A; Cavallo, F; Consolino, L; Conti, L; Longo, DL; Reineri, F	1
James, MO; Mangal, N; Schmidt, S; Stacpoole, PW	1
Curci, A; Cutrignelli, A; Denora, N; Franco, M; Laquintana, V; Lopalco, A; Lopedota, A	1
Abdelmalak, M; Coats, BS; Langaee, T; Lew, A; Neiberger, RE; Ramezani, R; Shankar, MN; Shroads, AL; Stacpoole, PW; Subramony, SH	1
Fu, R; Hayes, A; Lohan-Mannion, D; Moriarty, RM; Robinson, ST; Shangraw, RE	1
Hayashi, J; Nakada, K; Ogasawara, E	1
Stacpoole, PW	1
Ishida, T; Kawanishi, K	2
Agbenyega, T; Ansong, D; Bedu-Addo, G; Bhattaram, VA; Derendorf, H; Henderson, GN; Hutson, AD; Krishna, S; Nagaraja, NV; Owusu-Ofori, A; Planche, T; Shroads, AL; Stacpoole, PW	1
Hutson, AD; Nagaraja, NV; Stacpoole, PW	1
Bicego, KC; Branco, LG; Gargaglioni, LH; Steiner, AA	1
Krishna, S; Planche, T	2
Planche, T	1
Barnes, C; Bunch, ST; Carney, PR; Felitsyn, NM; Fennell, EM; Gilmore, RL; Greer, M; Henderson, GN; Hutson, AD; Kerr, DS; Neiberger, RE; O'Brien, RG; Perkins, LA; Quisling, RG; Shroads, AL; Shuster, JJ; Silverstein, JH; Stacpoole, PW; Theriaque, DW; Valenstein, E	1
Berendzen, K; Shuster, J; Stacpoole, PW; Theriaque, DW	1
Carney, PR; Gilbert, LR; Neiberger, RE; Shuster, JJ; Stacpoole, PW; Theriaque, DW; Valenstein, E	1
Caretti, D; De Garavilla, L; Durkot, MJ; Francesconi, R	1
Bajaj, N; Chapman, D; Holloway, PA; Knox, K; Krishna, S; O'Brien, R; Stacpoole, PW; White, NJ	1
Agbenyega, T; Angus, BJ; Bedu-Addo, G; Henderson, G; Krishna, S; O'Brien, R; Ofori-Amanfo, G; Stacpoole, PW; Szwandt, IS	1
Amir, N; Barash, V; De Vivo, DC; Elpeleg, ON; Jakobs, C; Ruitenbeek, W	1
Camara, A; Levine, M; Nudel, DB	1
Gallaher, EJ; Hromco, J; Robinson, ST; Shangraw, RE; Winter, R	1
Abe, T; Kamoshita, S; Nakamura, G; Sakakihara, Y; Tokoeda, Y	1
Davis, TM; Holloway, PA; Karter, D; Krishna, S; Pukrittayakamee, S; Supanaranond, W; Supputamongkol, Y; White, NJ	1
Bolling, SF; Ullrich, K; Wahr, JA	1
McGuinness, ME; Talbert, RL	1
Blecic, S; Preiser, JC; Vincent, JL; Zhang, H	1
Eivins, S; el-Shanti, H; Klein, JM; Rhead, WJ; Tóth, PP	1
Biban, P; Bordugo, A; Burlina, AB; DiMauro, S; Garavaglia, B; Milanesi, O; Zacchello, F	1
Edelman, NH; Petrozzino, JJ; Santiago, TV; Scardella, AT	1
Holm, IA; Korson, MS; Krawiecki, N; North, K; Shoffner, JM	1
Craigen, WJ	1
DeMaria, EJ; Gore, DC; Hibbert, JM; Jahoor, F	1
Krishna, S; Kuile, FT; Pukrittayakamee, S; Ruprah, M; Supanaranond, W; White, NJ	1
Curry, SH; Derendorf, H; Henderson, GN; Stacpoole, PW; Wright, EC	1
Davydova, N; Henderson, GN; James, MO; Stacpoole, PW; Yan, Z	1
Ito, M; Iwamoto, H; Kondo, S; Kuroda, Y; Matsuda, J; Miyazaki, M; Mori, K; Naito, E; Saijo, T; Yokota, I; Yoneda, Y	1
Barnes, CL; Cannon, SL; Hurbanis, MD; Kerr, DS; Stacpoole, PW	1
Preiser, JC; Vincent, JL	1
Ishida, T; Kajikawa, T; Kawanishi, K; Tada, S	1
Bachert, P; Langhans, CD; Mayatepek, E; Rating, D; Ruitenbeek, W; Schulze, A	1
Aynsley-Green, A; Leonard, JV; Morris, AA	1
Henderson, GN; James, MO; Stacpoole, PW; Yan, Z	1
Agbenyega, T; Angus, BJ; Baffoe-Bonnie, B; Bedu-Addo, G; Guyton, T; Krishna, S; Stacpoole, PW	1
Barbee, RW; Kline, JA; Watts, JA	1
Chandy, MJ; Ravindra, J	1
Arnon, S; Dolfin, T; Elpeleg, O; Litmanovits, I; Regev, R	1
Agbenyega, T; Ansong, D; Bedo-Addo, G; Derendorf, H; Henderson, G; Hutson, A; Krishna, S; Nagaraja, NV; Owusu-Ofori, A; Planche, T; Shroads, AL; Stacpoole, PW	1
George, JC; Hutson, AD; Neiberger, RE; Perkins, LA; Stacpoole, PW; Theriaque, DW	1
Hu, CL	1
Baumgartner, TG; Bersin, RM; Buchalter, S; Curry, SH; Duncan, CA; Harman, EM; Henderson, GN; Jenkinson, S; Stacpoole, PW; Wright, EC	1
Graf, H; Peer, G	1
Cheema-Dhadli, S; Halperin, ML; Kamel, KS	1
Cain, SM; Curtis, SE	1
Holloway, PA; Krishna, S; White, NJ	1
Hashimoto, T; Ito, M; Kuroda, Y; Naito, E; Saijo, T; Takeda, E	1
Buckley, BJ; Gootman, N; Kaplan, NA; Nudel, DB; Peterson, BJ; Weinhaouse, E	1
Moulart, D; Preiser, JC; Vincent, JL	1
Perret, C; Potin, M	1
Goodman, JC; Grossman, RG; Priessman, A; Robertson, CS	1
Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF	1
Ito, M; Kobashi, H; Kuroda, Y; Naito, E; Saijo, T; Takeda, E; Toshima, K; Yokota, I	1
Fujita, Y; Fukui, A; Ohsumi, A; Sakai, T; Takaori, M; Yoshida, H	1
Cammenga, R; Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF	1
Kemmotsu, O; Nakata, F; Tanaka, R	2
Biros, MH; Dimlich, RV; Kaplan, J; Widman, DW	1
Kobashi, H; Kuroda, Y; Miyao, M; Naito, E; Takeda, E; Yokota, I	1
Caputo, G; Delgado Paredes, C; Egler, J; Fleisher, G; Schaible, D; Sheikh, A; Swedlow, D	1
MacMillan, H; Petrova-Benedict, R; Robinson, BH; Sherwood, WG	1
Barsan, WG; Eymer, V; Gin-Shaw, SL; Hedges, J	1
Edelman, NH; Neubauer, JA; Simone, A	1
Egler, J; Ferraro, N; Mancini, DM; Wilson, JR	1
Harman, EM; Lorenz, AC; Stacpoole, PW; Thomas, RG	1
Kinney, EL; Wright, RJ	1
Kuroda, Y; Miyao, M; Naito, E; Takeda, E; Yokota, I	1
Kamoshita, S; Kodama, H; Kodama, M; Okabe, I; Orii, T; Yamaguchi, S	1
Biros, MH; Dimlich, RV; Kaplan, J	1

Reviews

9 review(s) available for dichloroacetic acid and Acidosis, Lactic

Article	Year
[Acute complications due to diabetes mellitus: Lactic acidosis]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 10 Topics: Acidosis, Lactic; Acute Disease; Diabetes Complications; Dichloroacetic Acid; Glucose; Humans; Insulin; Peritoneal Dialysis; Sodium Bicarbonate	2002
Efficacy of dichloroacetate as a lactate-lowering drug. Journal of clinical pharmacology, 2003, Volume: 43, Issue:7 Topics: Acidosis, Lactic; Administration, Oral; Clinical Trials as Topic; Dichloroacetic Acid; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Male	2003
The relevance of malaria pathophysiology to strategies of clinical management. Current opinion in infectious diseases, 2005, Volume: 18, Issue:5 Topics: Acidosis, Lactic; Antimalarials; Consciousness Disorders; Dichloroacetic Acid; Humans; Hypoglycemia; Malaria, Falciparum	2005
Severe malaria: metabolic complications. Current molecular medicine, 2006, Volume: 6, Issue:2 Topics: Acetylcysteine; Acidosis, Lactic; Antimalarials; Dichloroacetic Acid; Humans; Hypoglycemia; Malaria, Falciparum	2006
Phenformin-induced lactic acidosis: a forgotten adverse drug reaction. The Annals of pharmacotherapy, 1993, Volume: 27, Issue:10 Topics: Acidosis, Lactic; Diabetes Mellitus; Dichloroacetic Acid; Drug and Narcotic Control; Humans; Insulin; Male; Middle Aged; Phenformin; Renal Dialysis; Sodium Bicarbonate; Sodium Chloride	1993
[Should bicarbonates still be administered in lactic acidosis?]. Revue medicale de Bruxelles, 1993, Volume: 14, Issue:5 Topics: Acidosis, Lactic; Bicarbonates; Carbon Dioxide; Carbonates; Dichloroacetic Acid; Drug Combinations; Humans; Hydrogen-Ion Concentration; Sodium Bicarbonate; Tromethamine	1993
[Lactate metabolism and lactic acidosis]. Rinsho byori. The Japanese journal of clinical pathology, 1998, Volume: 46, Issue:8 Topics: Acidosis, Lactic; Alcoholism; Cardiovascular Diseases; Diabetes Complications; Dichloroacetic Acid; Female; Humans; Insulin; Lactates; Male; Neoplasms; Sodium Bicarbonate; Tromethamine	1998
[Therapy of metabolic acidosis]. Deutsche medizinische Wochenschrift (1946), 1991, Jul-12, Volume: 116, Issue:28-29 Topics: Acidosis; Acidosis, Lactic; Alkalies; Animals; Bicarbonates; Carbonates; Diabetic Ketoacidosis; Dichloroacetic Acid; Dogs; Drug Combinations; Humans; Sodium; Sodium Bicarbonate	1991
Effects of various doses of sodium dichloroacetate on hyperlactatemia in fed ischemic rats. Annals of emergency medicine, 1989, Volume: 18, Issue:11 Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Food; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains	1989

Trials

13 trial(s) available for dichloroacetic acid and Acidosis, Lactic

Article	Year
Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children. Journal of clinical pharmacology, 2018, Volume: 58, Issue:2 Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Female; Glutathione Transferase; Humans; Infant; Male; Models, Biological; Young Adult	2018
Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children. Journal of clinical pharmacology, 2003, Volume: 43, Issue:4 Topics: Acidosis, Lactic; Antimalarials; Child, Preschool; Dichloroacetic Acid; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Humans; Injections, Intramuscular; Malaria, Falciparum; Male; Models, Biological; Quinine; Time Factors	2003
Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. Pediatrics, 2006, Volume: 117, Issue:5 Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; Infant; Lactates; Male; Mitochondrial Diseases; Neurologic Examination; Neuropsychological Tests; Pyruvate Dehydrogenase Complex Deficiency Disease; Quality of Life	2006
Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate. Pediatrics, 2008, Volume: 121, Issue:5 Topics: Acidosis, Lactic; Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Double-Blind Method; Female; Humans; Infant; Kaplan-Meier Estimate; Lactic Acid; Male; Mitochondrial Encephalomyopathies; Neural Conduction; Pyruvate Dehydrogenase Complex Deficiency Disease	2008
Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria. QJM : monthly journal of the Association of Physicians, 1995, Volume: 88, Issue:5 Topics: Acidosis, Lactic; Child; Child, Preschool; Dichloroacetic Acid; Drug Therapy, Combination; Female; Humans; Infant; Lactates; Lactic Acid; Malaria; Male; Quinine	1995
Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans. Anesthesiology, 1994, Volume: 81, Issue:5 Topics: Acidosis, Lactic; Adult; Blood Glucose; Dichloroacetic Acid; Female; Humans; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Liver Transplantation; Male; Middle Aged; Sodium Bicarbonate	1994
The disposition and effects of two doses of dichloroacetate in adults with severe falciparum malaria. British journal of clinical pharmacology, 1996, Volume: 41, Issue:1 Topics: Acidosis, Lactic; Adult; Dichloroacetic Acid; Electrocardiography; Female; Half-Life; Humans; Lactates; Malaria, Falciparum; Male; Prospective Studies	1996
Pharmacokinetics of dichloroacetate in adult patients with lactic acidosis. Journal of clinical pharmacology, 1997, Volume: 37, Issue:5 Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Dichloroacetic Acid; Female; Humans; Male; Middle Aged	1997
Kinetics and metabolism of chloral hydrate in children: identification of dichloroacetate as a metabolite. Biochemical and biophysical research communications, 1997, Jun-27, Volume: 235, Issue:3 Topics: Acidosis, Lactic; Adolescent; Biotransformation; Child; Child, Preschool; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Gas Chromatography-Mass Spectrometry; Glucuronates; Humans; Hypnotics and Sedatives; Infant; Kinetics	1997
Glucose and lactate kinetics in children with severe malaria. The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:4 Topics: Acidosis, Lactic; Antimalarials; Artemisinins; Artesunate; Blood Glucose; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; Infant; Insulin; Kinetics; Lactic Acid; Malaria, Falciparum; Male; Quinine; Sesquiterpenes	2000
Population pharmacokinetics of intramuscular quinine in children with severe malaria. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:6 Topics: Acidosis, Lactic; Animals; Antimalarials; Child; Child, Preschool; Dichloroacetic Acid; Female; Ghana; Half-Life; Hemodynamics; Humans; Infant; Injections, Intramuscular; Malaria, Falciparum; Male; Metabolic Clearance Rate; Plasmodium falciparum; Quinine	2001
A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group. The New England journal of medicine, 1992, Nov-26, Volume: 327, Issue:22 Topics: Acidosis, Lactic; Arteries; Dichloroacetic Acid; Female; Humans; Hydrogen-Ion Concentration; Lactates; Male; Middle Aged; Survival Rate	1992
Effect of dichloroacetate on the exercise performance of patients with heart failure. Journal of the American College of Cardiology, 1988, Volume: 12, Issue:6 Topics: Acetates; Acidosis, Lactic; Adult; Aged; Dichloroacetic Acid; Exercise; Fatigue; Heart Failure; Humans; Lactates; Lactic Acid; Leg; Male; Middle Aged; Muscles; Oxygen Consumption; Regional Blood Flow	1988

Other Studies

60 other study(ies) available for dichloroacetic acid and Acidosis, Lactic

Article	Year
Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses. Drug metabolism and disposition: the biological fate of chemicals, 2020, Volume: 49, Issue:6 Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Drugs, Investigational; Female; Fetal Blood; Glutathione Transferase; Maternal-Fetal Exchange; Metabolic Networks and Pathways; Mitochondrial Diseases; Obstetric Labor Complications; Placental Circulation; Pregnancy; Sheep	2020
In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging. International journal of oncology, 2017, Volume: 51, Issue:2 Topics: Acidosis, Lactic; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Drug Resistance; Female; Glycolysis; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Imaging; Mice	2017
Pharmaceutical preformulation studies and paediatric oral formulations of sodium dichloroacetate. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Jan-15, Volume: 127 Topics: Acidosis, Lactic; Administration, Oral; Chemistry, Pharmaceutical; Child; Dichloroacetic Acid; Excipients; Humans; Sweetening Agents; Tablets; Taste	2019
Long-term safety of dichloroacetate in congenital lactic acidosis. Molecular genetics and metabolism, 2013, Volume: 109, Issue:2 Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; Lactic Acid; Male; Middle Aged; Randomized Controlled Trials as Topic; Treatment Outcome; Young Adult	2013
Dichloroacetate stabilizes the intraoperative acid-base balance during liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2008, Volume: 14, Issue:7 Topics: Acidosis, Lactic; Adult; Alkalosis; Dichloroacetic Acid; Female; Humans; Intraoperative Period; Liver Transplantation; Male; Middle Aged; Postoperative Period	2008
Change of purpose. Nature, 2010, May-20, Volume: 465, Issue:7296 Topics: Acidosis, Lactic; Animals; Antineoplastic Agents; Clinical Trials as Topic; Dichloroacetic Acid; Drug Industry; Humans; Off-Label Use; Patents as Topic; Rats; United States	2010
Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion. Human molecular genetics, 2010, Aug-15, Volume: 19, Issue:16 Topics: Acidosis, Lactic; Animals; Behavior, Animal; Cell Respiration; Dichloroacetic Acid; Disease Models, Animal; DNA, Mitochondrial; Electron Transport Complex IV; Female; Gene Expression; Genes, Mitochondrial; Humans; Lactic Acid; Male; Mice; Mice, Inbred Strains; Mitochondria; Mitochondrial Diseases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Sequence Deletion; Trans-Activators; Transcription Factors	2010
Why are there no proven therapies for genetic mitochondrial diseases? Mitochondrion, 2011, Volume: 11, Issue:5 Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Financing, Government; Humans; MELAS Syndrome; Mitochondrial Diseases; Neglected Diseases; Randomized Controlled Trials as Topic; Rare Diseases; Societies, Medical; Ubiquinone; United States	2011
Lactate as a modulator of hypoxia-induced hyperventilation. Respiratory physiology & neurobiology, 2003, Oct-16, Volume: 138, Issue:1 Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Enzyme Inhibitors; Hyperventilation; Hypoxia; Lactic Acid; Male; Oxygen Consumption; Pulmonary Ventilation; Rats; Rats, Wistar; Respiration	2003
Malaria and fluids--balancing acts. Trends in parasitology, 2005, Volume: 21, Issue:12 Topics: Acidosis, Lactic; Animals; Child; Child, Preschool; Clinical Trials as Topic; Dichloroacetic Acid; Humans; Malaria, Falciparum; Severity of Illness Index; Shock, Septic; Sodium Chloride	2005
Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency. Mitochondrion, 2006, Volume: 6, Issue:3 Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic Acid; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Mitochondria; Models, Biological; Mutation; Pyruvate Dehydrogenase Complex; Pyruvate Dehydrogenase Complex Deficiency Disease	2006
The effects of dichloroacetate on lactate accumulation and endurance in an exercising rat model. International journal of sports medicine, 1995, Volume: 16, Issue:3 Topics: Acidosis, Lactic; Animals; Body Temperature Regulation; Dichloroacetic Acid; Disease Models, Animal; Enzyme Activation; Glycogen; Lactates; Liver; Male; Muscle Fatigue; Muscle, Skeletal; Oxidation-Reduction; Physical Endurance; Physical Exertion; Pyruvate Dehydrogenase Complex; Pyruvates; Rats; Rats, Sprague-Dawley; Running; Time Factors	1995
Plasmodium berghei infection: dichloroacetate improves survival in rats with lactic acidosis. Experimental parasitology, 1995, Volume: 80, Issue:4 Topics: Acidosis, Lactic; Anemia; Animals; Blood Glucose; Dichloroacetic Acid; Disease Models, Animal; Drug Therapy, Combination; Hematocrit; Lactates; Logistic Models; Malaria; Male; Parasitemia; Plasmodium berghei; Quinine; Random Allocation; Rats; Rats, Wistar	1995
Congenital lacticacidemia caused by lipoamide dehydrogenase deficiency with favorable outcome. The Journal of pediatrics, 1995, Volume: 126, Issue:1 Topics: Acidosis, Lactic; Carnitine; Dichloroacetic Acid; Dihydrolipoamide Dehydrogenase; Fibroblasts; Humans; Infant; Ketosis; Lactates; Male; Movement Disorders; Muscles; Thiamine	1995
Comparative effects of bicarbonate, tris-(hydroxymethyl)aminomethane and dichloroacetate in newborn swine with normoxic lactic acidosis. Developmental pharmacology and therapeutics, 1993, Volume: 20, Issue:1-2 Topics: Acidosis, Lactic; Alkalies; Animals; Animals, Newborn; Bicarbonates; Cardiovascular System; Dichloroacetic Acid; Oxygen; Random Allocation; Swine; Tromethamine	1993
A rapid microassay for dichloroacetate in serum by gel-permeation chromatography. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1994, Volume: 32, Issue:2 Topics: Acidosis, Lactic; Adult; Child; Child, Preschool; Chromatography, Gas; Chromatography, Gel; Chromatography, High Pressure Liquid; Dichloroacetic Acid; Female; Humans; Infant; Male; Sensitivity and Specificity	1994
Dichloroacetate for lactic acidosis in severe malaria: a pharmacokinetic and pharmacodynamic assessment. Metabolism: clinical and experimental, 1994, Volume: 43, Issue:8 Topics: Acidosis, Lactic; Adolescent; Adult; Dichloroacetic Acid; Humans; Malaria, Falciparum; Middle Aged	1994
The use of dichloroacetate in the treatment of overwhelming hypoxic acidosis. Journal of cardiothoracic and vascular anesthesia, 1994, Volume: 8, Issue:1 Topics: Acidosis, Lactic; Animals; Bicarbonates; Blood Pressure; Cardiac Output; Cause of Death; Coronary Circulation; Dichloroacetic Acid; Dogs; Heart; Hemodynamics; Hydrogen-Ion Concentration; Hypoxia; Lactates; Myocardium; Oxygen Consumption; Renal Circulation; Sodium; Sodium Chloride; Stroke Volume; Vascular Resistance	1994
Transient improvement of congenital lactic acidosis in a male infant with pyruvate decarboxylase deficiency treated with dichloroacetate. The Journal of pediatrics, 1993, Volume: 123, Issue:3 Topics: Acidosis, Lactic; Dichloroacetic Acid; Humans; Infant, Newborn; Male; Pyruvate Decarboxylase; Pyruvate Metabolism, Inborn Errors	1993
Beneficial effect of sodium dichloroacetate in muscle cytochrome C oxidase deficiency. European journal of pediatrics, 1993, Volume: 152, Issue:6 Topics: Acidosis, Lactic; Cardiomyopathy, Hypertrophic; Cytochrome-c Oxidase Deficiency; Dichloroacetic Acid; Humans; Infant; Male; Muscles; Severity of Illness Index	1993
Respiratory muscle acidosis stimulates endogenous opioids during inspiratory loading. The American review of respiratory disease, 1993, Volume: 147, Issue:3 Topics: Acidosis, Lactic; Airway Resistance; Animals; Carbon Dioxide; Dichloroacetic Acid; Electromyography; Endorphins; Goats; Hydrogen-Ion Concentration; Male; Naloxone; Respiration; Respiratory Muscles; Time Factors	1993
Oxidative phosphorylation defect associated with primary adrenal insufficiency. The Journal of pediatrics, 1996, Volume: 128, Issue:5 Pt 1 Topics: Acidosis, Lactic; Adrenocorticotropic Hormone; Cataract; Dichloroacetic Acid; Female; Humans; Infant, Newborn; Lipid Metabolism, Inborn Errors; Mitochondria, Muscle; Oxidative Phosphorylation; Phenotype	1996
Leigh disease with deficiency of lipoamide dehydrogenase: treatment failure with dichloroacetate. Pediatric neurology, 1996, Volume: 14, Issue:1 Topics: Acidosis, Lactic; Amino Acids, Branched-Chain; Child, Preschool; Dichloroacetic Acid; Dihydrolipoamide Dehydrogenase; Enzyme Activation; Fatal Outcome; Female; Humans; Infant; Isoleucine; Lactates; Lactic Acid; Leigh Disease; Pyruvate Dehydrogenase Complex; Treatment Failure	1996
Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability. Annals of surgery, 1996, Volume: 224, Issue:1 Topics: Acidosis, Lactic; Adult; Blood Glucose; Breath Tests; Calorimetry, Indirect; Dichloroacetic Acid; Female; Humans; Lactates; Middle Aged; Oxygen; Oxygen Consumption; Pyruvates; Sepsis; Time Factors	1996
Concomitant administration of sodium dichloroacetate and vitamin B1 for lactic acidemia in children with MELAS syndrome. The Journal of pediatrics, 1997, Volume: 131, Issue:3 Topics: Acidosis, Lactic; Administration, Oral; Child; Dichloroacetic Acid; Drug Monitoring; Drug Therapy, Combination; Humans; Male; MELAS Syndrome; Severity of Illness Index; Thiamine	1997
Treatment of congenital lactic acidosis with dichloroacetate. Archives of disease in childhood, 1997, Volume: 77, Issue:6 Topics: Acidosis, Lactic; Adolescent; Child; Dichloroacetic Acid; Female; Humans; Infant; Infant, Newborn; Male; Mutation; Pyruvate Dehydrogenase Complex Deficiency Disease	1997
Specific therapies of biguanide-induced lactic acidosis. Anesthesiology, 1998, Volume: 89, Issue:1 Topics: Acidosis, Lactic; Biguanides; Dichloroacetic Acid; Humans	1998
In vivo methods useful for therapy monitoring in lactic acidosis. Journal of inherited metabolic disease, 1998, Volume: 21, Issue:6 Topics: Acidosis, Lactic; Carbon Isotopes; Carbon Radioisotopes; Dichloroacetic Acid; Female; Humans; Infant; Magnetic Resonance Imaging; Monitoring, Physiologic; Pyruvate Dehydrogenase Complex Deficiency Disease	1998
Raised cerebrospinal fluid glycerol concentration associated with use of dichloroacetate. Archives of disease in childhood, 1998, Volume: 79, Issue:3 Topics: Acidosis, Lactic; Child; Dichloroacetic Acid; Epilepsies, Myoclonic; Glycerol; Humans	1998
Determination of chloral hydrate metabolites in human plasma by gas chromatography-mass spectrometry. Journal of pharmaceutical and biomedical analysis, 1999, Volume: 19, Issue:3-4 Topics: Acetals; Acetates; Acidosis, Lactic; Administration, Oral; Child; Chloral Hydrate; Dichloroacetic Acid; Ethylene Chlorohydrin; Evaluation Studies as Topic; Gas Chromatography-Mass Spectrometry; Glucuronates; Glucuronides; Humans; Hydroxamic Acids; Reproducibility of Results; Sensitivity and Specificity; Trichloroacetic Acid	1999
Depletion of lactate by dichloroacetate reduces cardiac efficiency after hemorrhagic shock. Shock (Augusta, Ga.), 2000, Volume: 14, Issue:2 Topics: Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Drug Evaluation, Preclinical; Energy Metabolism; Enzyme Activation; Fatty Acids; Fluid Therapy; Hemodynamics; Isotonic Solutions; Lactic Acid; Myocardium; Pyruvate Dehydrogenase Complex; Resuscitation; Ringer's Lactate; Shock, Hemorrhagic	2000
Effect of dichloracetate on infarct size in a primate model of focal cerebral ischaemia. Neurology India, 2000, Volume: 48, Issue:3 Topics: Acidosis, Lactic; Animals; Brain Ischemia; Cerebral Cortex; Dichloroacetic Acid; Disease Models, Animal; Female; Infarction, Middle Cerebral Artery; Macaca radiata; Male; Pyruvate Dehydrogenase Complex	2000
Dichloroacetate treatment for severe refractory metabolic acidosis during neonatal sepsis. The Pediatric infectious disease journal, 2001, Volume: 20, Issue:2 Topics: Acidosis, Lactic; Dichloroacetic Acid; Humans; Infant, Newborn; Sepsis; Sodium Bicarbonate; Streptococcal Infections	2001
Renal manifestations of congenital lactic acidosis. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 39, Issue:1 Topics: Acidosis, Lactic; Adolescent; Adult; Bicarbonates; Blood Urea Nitrogen; Calcium; Child; Child, Preschool; Creatinine; Dichloroacetic Acid; Female; Humans; Infant; Kidney Diseases; Kidney Tubules; Lactic Acid; Male; Parathyroid Hormone; Phosphates; Pyruvate Dehydrogenase Complex Deficiency Disease; Treatment Outcome; Vitamin D	2002
[Treatment of experimental ischemic cerebral lactic acidosis in rats with dichloroacetate]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1992, Volume: 25, Issue:6 Topics: Acidosis, Lactic; Animals; Brain; Brain Ischemia; Dichloroacetic Acid; Lactates; Rats; Rats, Wistar; Reperfusion Injury	1992
Lactic acidosis, ketoacidosis, and energy turnover: "figure" you made the correct diagnosis only when you have "counted" on it--quantitative analysis based on principles of metabolism. The Mount Sinai journal of medicine, New York, 1992, Volume: 59, Issue:1 Topics: Acidosis, Lactic; Adult; Blood Glucose; Diabetic Ketoacidosis; Dichloroacetic Acid; Glucose; Humans; Hyperglycemia; Liver; Male; Middle Aged; Oxidation-Reduction	1992
Regional and systemic oxygen delivery/uptake relations and lactate flux in hyperdynamic, endotoxin-treated dogs. The American review of respiratory disease, 1992, Volume: 145, Issue:2 Pt 1 Topics: Acidosis, Lactic; Animals; Cardiac Output; Dichloroacetic Acid; Dogs; Endotoxins; Enzyme Activation; Escherichia coli; Female; Hindlimb; Ileum; Lactates; Male; Oxygen; Oxygen Consumption; Pyruvate Dehydrogenase Complex; Regional Blood Flow; Shock, Septic; Vascular Resistance	1992
[Lactic acidosis inpatients with diabetes mellitus]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49 Suppl Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Bicarbonates; Blood Glucose; Diabetic Ketoacidosis; Dichloroacetic Acid; Female; Humans; Insulin; Lactates; Lactic Acid; Male; Middle Aged; Sodium; Sodium Bicarbonate; Tromethamine	1991
Plasmodium berghei: lactic acidosis and hypoglycaemia in a rodent model of severe malaria; effects of glucose, quinine, and dichloroacetate. Experimental parasitology, 1991, Volume: 72, Issue:2 Topics: Acid-Base Equilibrium; Acidosis, Lactic; Animals; Carbon Dioxide; Dichloroacetic Acid; Disease Models, Animal; Glucose; Hematocrit; Hypoglycemia; Infusions, Intravenous; Insulin; Lactates; Malaria; Male; Oxygen; Plasmodium berghei; Pyruvates; Quinine; Rats; Rats, Inbred Strains	1991
Therapeutic effect of sodium dichloroacetate on visual and auditory hallucinations in a patient with MELAS. Neuropediatrics, 1991, Volume: 22, Issue:3 Topics: Acidosis, Lactic; Administration, Oral; Adult; Auditory Perception; Dichloroacetic Acid; Hallucinations; Humans; Lactates; Lactic Acid; Male; Mitochondria, Muscle; Neurocognitive Disorders; Neuromuscular Diseases; Pyruvates; Pyruvic Acid; Syndrome; Visual Perception	1991
Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis. Developmental pharmacology and therapeutics, 1990, Volume: 15, Issue:2 Topics: Acidosis, Lactic; Animals; Animals, Newborn; Bicarbonates; Blood Pressure; Cardiac Output; Dichloroacetic Acid; Heart Rate; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Pulmonary Gas Exchange; Sodium; Sodium Bicarbonate; Swine	1990
Dichloroacetate administration in the treatment of endotoxin shock. Circulatory shock, 1990, Volume: 30, Issue:3 Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Drug Evaluation; Endotoxins; Escherichia coli Infections; Hemodynamics; Lactose; Oxygen Consumption; Shock, Septic	1990
[Lactic acidosis and hyperlactatemia]. La Revue du praticien, 1990, Oct-01, Volume: 40, Issue:22 Topics: Acidosis, Lactic; Bicarbonates; Dichloroacetic Acid; Humans; Lactates	1990
Reduction in spinal cord postischemic lactic acidosis and functional improvement with dichloroacetate. Journal of neurotrauma, 1990,Spring, Volume: 7, Issue:1 Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Ischemia; Rabbits; Spinal Cord	1990
Effect of sodium dichloroacetate on human pyruvate metabolism. Brain & development, 1989, Volume: 11, Issue:3 Topics: Acetates; Acidosis, Lactic; Adolescent; Blood Platelets; Dichloroacetic Acid; Humans; Male; Muscular Diseases; Pyruvates; Pyruvic Acid	1989
[Dose dependent effects of dichloroacetate on lactic acidosis in dogs]. Masui. The Japanese journal of anesthesiology, 1989, Volume: 38, Issue:8 Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Dose-Response Relationship, Drug; Injections, Intravenous	1989
Effects of sodium dichloroacetate dose. Brain metabolites associated with cerebral ischemia. Annals of emergency medicine, 1989, Volume: 18, Issue:11 Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Fasting; Humans; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains	1989
[Comparative effects of dichloroacetate and sodium bicarbonate on plasma lactic acid levels in experimentally produced hypoxia]. Masui. The Japanese journal of anesthesiology, 1987, Volume: 36, Issue:7 Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; Lactates; Lactic Acid; Sodium; Sodium Bicarbonate	1987
Comparison of sodium bicarbonate with dichloroacetate treatment of hyperlactatemia and lactic acidosis in the ischemic rat. Resuscitation, 1988, Volume: 16, Issue:1 Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Blood Glucose; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Glycogen; Lactates; Male; Rats; Rats, Inbred Strains; Resuscitation; Sodium; Sodium Bicarbonate	1988
Detection of pyruvate metabolism disorders by culture of skin fibroblasts with dichloroacetate. Pediatric research, 1988, Volume: 23, Issue:6 Topics: Acetates; Acidosis, Lactic; Cells, Cultured; Child; Dichloroacetic Acid; Enzyme Activation; Female; Fibroblasts; Humans; Infant; Male; Mitochondria; Phosphoprotein Phosphatases; Pyruvate Dehydrogenase Complex Deficiency Disease; Pyruvates; Pyruvic Acid	1988
Effect of dichloroacetate in the treatment of anoxic lactic acidosis in dogs. Critical care medicine, 1986, Volume: 14, Issue:11 Topics: Acetates; Acidosis, Lactic; Animals; Bicarbonates; Carbon Dioxide; Dichloroacetic Acid; Dogs; Heart Arrest; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Models, Biological; Oxygen; Resuscitation; Sodium; Sodium Bicarbonate	1986
Variable clinical presentation in patients with defective E1 component of pyruvate dehydrogenase complex. The Journal of pediatrics, 1987, Volume: 111, Issue:4 Topics: Acidosis, Lactic; Adolescent; Brain Diseases; Cells, Cultured; Child; Child, Preschool; Dichloroacetic Acid; Fibroblasts; Humans; Infant; Infant, Newborn; Intellectual Disability; Muscle Hypotonia; Pyruvate Dehydrogenase Complex Deficiency Disease; Skin	1987
Effects of dichloroacetate following canine asphyxial arrest. Annals of emergency medicine, 1988, Volume: 17, Issue:5 Topics: Acetates; Acidosis, Lactic; Animals; Asphyxia; Blood Glucose; Blood Pressure; Carbon Dioxide; Dichloroacetic Acid; Dogs; Heart Arrest; Hydrogen-Ion Concentration; Lactates; Pulse; Resuscitation	1988
Role of brain lactic acidosis in hypoxic depression of respiration. Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:3 Topics: Acidosis, Lactic; Animals; Brain; Carbon Monoxide; Cats; Chemoreceptor Cells; Denervation; Dichloroacetic Acid; Hypoxia; Lactates; Lactic Acid; Male; Oxygen; Phrenic Nerve; Respiration	1988
Dichloroacetate in the treatment of lactic acidosis. Annals of internal medicine, 1988, Volume: 108, Issue:1 Topics: Acetates; Acidosis, Lactic; Adolescent; Adult; Aged; Dichloroacetic Acid; Female; Hemodynamics; Humans; Infant; Infant, Newborn; Male; Middle Aged; Prospective Studies	1988
Dichloroacetate and lactic acidosis. Annals of internal medicine, 1988, Sep-01, Volume: 109, Issue:5 Topics: Acetates; Acidosis, Lactic; Adult; Algorithms; Animals; Dichloroacetic Acid; Horses; Humans	1988
Congenital lactic acidosis. Enzyme, 1987, Volume: 38, Issue:1-4 Topics: Acetates; Acidosis, Lactic; Adolescent; Decarboxylation; Dichloroacetic Acid; Humans; Lactates; Male; Pyruvates	1987
[Effect of dichloroacetate on plasma lactic acid in experimentally produced hypoxia]. Masui. The Japanese journal of anesthesiology, 1986, Volume: 35, Issue:12 Topics: Acetates; Acidosis, Lactic; Animals; Dichloroacetic Acid; Dogs; Hemodynamics; Hypoxia; Lactates; Lactic Acid	1986
Renal effects of dichloroacetate in vivo. Clinica chimica acta; international journal of clinical chemistry, 1986, Nov-15, Volume: 160, Issue:3 Topics: Acetates; Acidosis, Lactic; Administration, Oral; Child, Preschool; Dichloroacetic Acid; Gas Chromatography-Mass Spectrometry; Humans; Kidney; Lactates; Lactic Acid; Male; Pyruvates; Pyruvic Acid	1986
Dichloroacetate treatment of ischemic cerebral lactic acidosis in the fed rat. Annals of emergency medicine, 1987, Volume: 16, Issue:3 Topics: Acetates; Acidosis, Lactic; Animals; Blood Glucose; Blood Pressure; Brain Ischemia; Dichloroacetic Acid; Food; Hematocrit; Lactates; Male; Rats; Rats, Inbred Strains	1987