dicarbethoxydihydrocollidine has been researched along with Disease Models, Animal in 67 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (5.97) | 18.7374 |
1990's | 1 (1.49) | 18.2507 |
2000's | 10 (14.93) | 29.6817 |
2010's | 38 (56.72) | 24.3611 |
2020's | 14 (20.90) | 2.80 |
Authors | Studies |
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Adhikari, N; Barnhart, S; Bornfeldt, KE; Hall, JL; Kanter, JE; Kramer, F; Shimizu-Albergine, M; Wall, VZ; Wight, TN | 1 |
Fujimoto, M; Gomi, M; Hashimoto, N; Hayase, M; Marumo, T; Masutani, H; Nozaki, K; Takagi, Y; Yodoi, J; Zhou, F | 1 |
Assimakopoulos, SF; Chroni, E; Faropoulos, K; Georgiou, C; Grintzalis, K; Karageorgos, N; Konstantinou, D; Mavrakis, A; Papapostolou, I | 1 |
Desai, MS; Karpen, SJ; Kosters, A; Lam, F; Shabier, Z; Taylor, M; Thevananther, S | 1 |
Awuah, P; Monga, SP; Singh, S; Thompson, MD | 1 |
Li, PA; Lu, B; Ma, Y; Mehta, SL | 1 |
Altindag, B; Kuscuoglu, U; Lehwald, N; Sukhotnik, I; Sylvester, KG; Tao, GZ | 1 |
Bardag-Gorce, F; Canaan, A; French, BA; French, SW; Li, J; Oliva, J; Tillman, B | 1 |
Bardag-Gorce, F; French, BA; French, SW; Li, J; Lue, YH; Montgomery, RO; Nan, L; Riley, NE | 1 |
Chang, ML; Chang, PY; Chen, JC; Yeh, CT | 1 |
Lelli, SM; Mazzetti, MB; San Martín de Viale, LC | 1 |
Fisher, RC; Kim, CW; Kim, HJ; Kim, S; Lee, MJ; Shin, JS | 1 |
Denk, H; Fickert, P; Fuchsbichler, A; Jaeschke, H; Marschall, HU; Moustafa, T; Stöger, U; Trauner, M; Tsybrovskyy, O; Weiglein, AH; Zatloukal, K | 1 |
Fuerer, C; Ghole, S; Hu, M; Jeong, YJ; Kurobe, M; Nusse, R; Sylvester, KG | 1 |
Blekkenhorst, GH; Cook, ES; Eales, L | 1 |
De Matteis, F; Gibbs, AH; Ingall, G; Tephly, TR | 1 |
Denk, H; Factor, VM; Fuchsbichler, A; Preisegger, KH; Stumptner, C; Thorgeirsson, SS | 1 |
Bickers, DR; Harber, LC; Kappas, A; Keogh, L | 1 |
Harrison, GG; Meissner, PN; Moore, MR | 1 |
Cai, X; Dong, H; Gu, T; Guo, Y; Li, B; Li, F; Lu, L; Shen, B; Shen, Z; Xu, X; Zhu, J | 1 |
Nejak-Bowen, K | 1 |
Abrigo, J; Aguirre, F; Arrese, M; Cabello-Verrugio, C; Cabrera, D; Marín, T; Simon, F; Tacchi, F; Vilos, C | 1 |
Argemi, J; Bataller, R; Belorkar, A; Dubuquoy, L; Fouts, DE; Furuya, S; Katou, Y; Kono, H; Rusyn, I; Schnabl, B; Uehara, T; Vadigepalli, R | 1 |
Dhanani, M; Head, BP; Kim, KH; Kim, SY; Leem, J; Patel, HH; Roth, DM; Schilling, JM; Zemljic-Harpf, AE | 1 |
Banales, JM; Bates, DO; Bhalla, SR; Boulter, L; Chen, P; Dean, CH; Henderson, DJ; Jarman, EJ; Kendall, TJ; Mellin, RP; Noll, ATR; Olde Damink, SW; Raven, A; Sansom, OJ; Schaap, FG; Tsokkou, P; Waddell, SH; Wilson, DH; Wilson, ML; Younger, NT | 1 |
Baker, D; Beraza, N; Brion, A; Echeandia, M; Galduroz, M; Goldson, A; Hildebrand, F; Isaacs-Ten, A; Moreno-Gonzalez, M; Parker, A; Patterson, AM; Philo, M; Rushbrook, SM | 1 |
Bai, L; Chen, Y; Shi, Y; Zhang, J; Zhang, X; Zhou, Y | 1 |
Ariyasu, T; Baba, R; Harada, M; Hino, K; Honma, Y; Katsuki, Y; Kawashima, A; Mihara, H; Sato-Morita, M | 1 |
Cheng, L; Du, B; Tan, XH; Wang, F; Zhang, HF | 1 |
Aseem, SO; Banales, JM; Chi, C; Chowdhury, S; De Assuncao, TM; Hamdan, FH; Huebert, RC; Jalan-Sakrikar, N; Johnsen, SA; Navarro-Corcuera, A; Shah, VH | 1 |
Fang, S; Li, Y; Ma, Y; Shi, R; Wang, G; Wang, T; Wang, Y; Wu, J; Xue, H | 1 |
Alves Souza Carvalhais, N; Cordi, S; Dauguet, N; De Greef, V; Di-Luoffo, M; Gérard, C; Halder, G; Jacquemin, P; Komuta, M; Konobrocka, K; Lamoline, F; Lemaigre, FP; Loriot, A; Manzano-Núñez, F; Pirenne, S; Saandi, T | 1 |
Ravichandra, A; Schwabe, RF | 1 |
Bellet, MM; Costantini, C; D'Onofrio, F; Giovagnoli, S; Mosci, P; Pariano, M; Puccetti, M; Renga, G; Ricci, M; Romani, L; Santarelli, I; Stincardini, C | 1 |
Abiru, H; Jemail, L; Kawai, C; Kotani, H; Minami, H; Miyao, M; Tamaki, K | 1 |
Kakimoto, K; Kimura, H; Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Shiromizu, S; Tsuruta, A; Watanabe, M | 1 |
Cornuet, P; Kakar, S; Michael, AA; Molina, L; Monga, SP; Nejak-Bowen, KN; Poddar, M; Pradhan-Sundd, T; Russell, JO; Singh, S; Sundd, P; Vats, R; Watkins, SC | 1 |
Abuja, PM; Denk, H; Kratky, D; Lahiri, P; Nikam, A; Patankar, JV; Sachdev, V; Somlapura, M; Zatloukal, K | 1 |
Dai, Z; Ott, M; Sharma, AD; Shen, X; Song, G; Tsay, HC; Yuan, Q | 1 |
Coll, M; Pose, E; Sancho-Bru, P | 1 |
Chen, K; Kong, D; Sun, J; Wang, J; Yang, R; Zhang, N | 1 |
Alemany, A; Anakk, S; Camargo, FD; Dawson, PA; Dill, MT; Matsushita, Y; Miyazaki, M; Ono, N; Ordovas-Montanes, J; Pepe-Mooney, BJ; Rao, A; Sen, A; Shalek, AK; van Oudenaarden, A | 1 |
Alford, JL; Bergling, S; Bouwmeester, T; Carballido-Perrig, N; Cobos, CM; Cochran, NR; Cong, F; Cuttat, R; Greenbaum, LE; Gubser Keller, C; Hoffman, GR; Hoppe, PS; Jetzer, J; Kinzel, B; Lugus, JJ; Mao, X; McAllister, G; Morelli, L; Neri, M; Nicholson, TB; Nigsch, F; Orsini, V; Pikiolek, M; Planas-Paz, L; Reece-Hoyes, JS; Roma, G; Russ, C; Sailer, AW; Schuierer, S; Schwarzer, W; Sigoillot, F; Sun, T; Syed, M; Tchorz, JS; Terracciano, LM; Waldt, A; Yang, Y; Yang, Z; Zhang, L | 1 |
Csizmadia, E; Enjyoji, K; Feldbrügge, L; Jiang, ZG; Longhi, MS; Popov, YV; Robson, SC; Rothweiler, S; Vaid, K | 1 |
Ernst, SA; Griggs, NW; Herrmann, H; Kwan, R; Maitra, D; Omary, MB; Singla, A; Snider, NT | 1 |
Desai, MS; Eblimit, Z; Karpen, SJ; Kosters, A; Moore, DD; Penny, DJ; Thevananther, S | 1 |
Sekiya, S; Suzuki, A | 1 |
Haybaeck, J; Kufferath, I; Landegren, U; Thueringer, A; Zatloukal, B; Zatloukal, K | 1 |
Fontana, RJ; Jang, YJ; Omary, MB; Weerasinghe, SV | 1 |
Greenbaum, LE; Kaestner, KH; Shin, S; Upadhyay, N | 1 |
Amstislavskiy, V; Denk, H; Grimm, C; Hache, H; Kashofer, K; Lehrach, H; Osprian, I; Pandey, V; Ralser, M; Starmann, J; Sultan, M; Sültmann, H; Trauner, M; Wierling, C; Yaspo, ML; Zatloukal, K | 1 |
Eguchi, A; Feldstein, AE; Font-Burgada, J; Johnson, CD; Karin, M; Povero, D; Wree, A | 1 |
Chen, Y; Fickert, P; Gassler, N; Guldiken, N; Haybaeck, J; Jeon, MK; Mohammed, HH; Pollheimer, MJ; Spurny, M; Strnad, P; Trautwein, C | 1 |
Abiru, H; Ishida, T; Jemail, L; Kawai, C; Kotani, H; Miyao, M; Tamaki, K | 1 |
Horisawa, K; Matsuda-Ito, K; Miura, S; Ohkawa, Y; Sekiya, S; Suzuki, A; Takashima, Y; Terada, M | 1 |
Brondell, K; Gao, Y; Greenbaum, LE; Hurtt, R; Kaestner, KH; Li, Z; Sackett, SD; Wells, RG | 1 |
Bowen, WB; Lu, A; Misse, A; Monga, SP; Singh, S; Thompson, MD; Wickline, ED | 1 |
Cho, BH; Jeong, YJ; Kim, HT; Kim, JC; Risal, P; Sylvester, KG | 1 |
Dong, W; He, YQ; Hu, L; Li, YQ; Li, Z; Lin, Y; Liu, Q; Luo, T; Tang, L; Wang, C; Wang, HY; Wu, FQ; Wu, MC; Yan, HX; Yang, W; Yu, LX; Zhang, HL; Zhang, J; Zheng, LY; Zou, SS | 1 |
Conner, EA; Factor, VM; Ishikawa, T; Kitade, M; Marquardt, JU; Raggi, C; Seo, D; Thorgeirsson, SS | 1 |
Denk, H; Fickert, P; Haybaeck, J; Hesse, M; Kolbe, T; Magin, TM; Müller, H; Stumptner, C; Thueringer, A; Trauner, M; Tsybrovskyy, O; Zatloukal, K | 1 |
Bhutta, AQ; Coronel, E; Freedman, SD; Ketwaroo, GA; Martin, CR; Popov, Y; Schuppan, D; Zaman, MM | 1 |
Abiru, H; Kotani, H; Manabe, S; Miyao, M; Ozeki, M; Tamaki, K; Tsuruyama, T | 1 |
Faut, M; Mazzetti, MB; Paiz, A; San Martín de Viale, LC | 1 |
Bardag-Gorce, F; French, BA; French, SW; Li, J; Lin, A; Oliva, J | 1 |
Bardag-Gorce, F; French, BA; French, SW; Li, J; Oliva, J | 1 |
Amidi, F; Bardag-Gorce, F; Dedes, J; French, BA; French, SW; Habibi, A; Li, J; McPhaul, L; Nguyen, S; Oliva, J | 1 |
67 other study(ies) available for dicarbethoxydihydrocollidine and Disease Models, Animal
Article | Year |
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Smooth muscle glucose metabolism promotes monocyte recruitment and atherosclerosis in a mouse model of metabolic syndrome.
Topics: Animals; Arteries; Atherosclerosis; Dicarbethoxydihydrocollidine; Disease Models, Animal; Disease Progression; Female; Glucose; Glucose Transporter Type 1; Glycolysis; Humans; Male; Metabolic Syndrome; Mice; Mice, Knockout; Monocytes; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Receptors, LDL | 2018 |
Attenuation of neuronal degeneration in thioredoxin-1 overexpressing mice after mild focal ischemia.
Topics: Analysis of Variance; Animals; Caspase 3; Cell Death; Chromones; Dicarbethoxydihydrocollidine; Disease Models, Animal; Enzyme Inhibitors; Humans; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Nerve Degeneration; Proto-Oncogene Proteins c-akt; Stilbamidines; Thioredoxins; Time Factors | 2009 |
Time-related alterations of superoxide radical levels in diverse organs of bile duct-ligated rats.
Topics: Animals; Brain; Common Bile Duct; Dicarbethoxydihydrocollidine; Disease Models, Animal; Fluorescent Dyes; Intestinal Mucosa; Jaundice, Obstructive; Kidney; Kinetics; Ligation; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Spectrometry, Fluorescence; Superoxides | 2009 |
Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis.
Topics: Animals; Bile Acids and Salts; Bile Duct Diseases; Cardiomyopathy, Hypertrophic; Dicarbethoxydihydrocollidine; Disease Models, Animal; Fatigue; Fatty Acids; Fibrosis; Gene Expression; Glycogen; Heart; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxygen Consumption; Phenotype; Receptors, Adrenergic, beta; Receptors, G-Protein-Coupled; Respiratory Function Tests; Signal Transduction | 2010 |
Disparate cellular basis of improved liver repair in beta-catenin-overexpressing mice after long-term exposure to 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
Topics: Animals; Apoptosis; beta Catenin; Blotting, Western; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dicarbethoxydihydrocollidine; Disease Models, Animal; Fluorescent Antibody Technique; Hepatocytes; Humans; Immunoenzyme Techniques; Immunoprecipitation; Liver; Male; Mice; Mice, Transgenic | 2010 |
Deficiency in the inner mitochondrial membrane peptidase 2-like (Immp21) gene increases ischemic brain damage and impairs mitochondrial function.
Topics: Analysis of Variance; Animals; Brain; Brain Infarction; Brain Injuries; Brain Ischemia; Circle of Willis; Dicarbethoxydihydrocollidine; Disease Models, Animal; DNA Damage; Endopeptidases; Male; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Mitochondria; Mitochondrial Proteins; Oxygen Consumption; Time Factors | 2011 |
Intestinal involvement during 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced chronic liver injury in a mouse model.
Topics: Animals; Apoptosis; beta Catenin; Cell Proliferation; Chemical and Drug Induced Liver Injury, Chronic; Dicarbethoxydihydrocollidine; Disease Models, Animal; Enterocytes; Intestinal Diseases; Intestinal Mucosa; Mice; Wnt Proteins | 2011 |
FAT10 knock out mice livers fail to develop Mallory-Denk bodies in the DDC mouse model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dicarbethoxydihydrocollidine; Disease Models, Animal; Gene Silencing; Hepatocytes; Humans; Interferon-gamma; Liver; Male; Mallory Bodies; Mice; Mice, Inbred C3H; Mice, Knockout; Organ Size; Proteasome Endopeptidase Complex; Protein Binding; Response Elements; Species Specificity; Ubiquitin; Ubiquitins | 2012 |
The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation.
Topics: Actins; Animals; Boronic Acids; Bortezomib; Cell Membrane; Cells, Cultured; Chlormethiazole; Dicarbethoxydihydrocollidine; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Fluorescent Antibody Technique, Indirect; Hepatocytes; Inclusion Bodies; Keratins; Male; Membrane Proteins; Mice; Mice, Inbred C3H; Microscopy, Confocal; Phosphoproteins; Protease Inhibitors; Pyrazines; Zonula Occludens-1 Protein | 2004 |
Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Dicarbethoxydihydrocollidine; Disease Models, Animal; Female; Isocyanates; Ligation; Liver Cirrhosis; Male; Mice; Mice, Inbred Strains; Naphthalenes; Propanols | 2005 |
Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species.
Topics: Allylisopropylacetamide; Animals; Dicarbethoxydihydrocollidine; Disease Models, Animal; Female; Glucose; Heme; Lipid Peroxidation; Liver; Luminescent Measurements; Porphyria, Acute Intermittent; Rats; Rats, Wistar; Reactive Oxygen Species; Urine | 2005 |
Streptozotocin-induced diabetes can be reversed by hepatic oval cell activation through hepatic transdifferentiation and pancreatic islet regeneration.
Topics: Animals; Blood Glucose; Cell Differentiation; Diabetes Mellitus, Experimental; Dicarbethoxydihydrocollidine; Disease Models, Animal; Gene Expression Regulation, Developmental; Hepatocytes; Hyperglycemia; Insulin; Insulin Secretion; Insulin-Secreting Cells; Liver; Mice; Mice, Inbred C57BL; Organ Specificity; Regeneration; Streptozocin | 2007 |
A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis.
Topics: Animals; Bile Acids and Salts; Bile Ducts; Cholangitis, Sclerosing; Cholesterol; Dicarbethoxydihydrocollidine; Disease Models, Animal; Glutathione; Hydroxyproline; Immunohistochemistry; In Situ Hybridization; Liver; Liver Cirrhosis, Biliary; Male; Mice; Models, Biological; Multidrug Resistance-Associated Proteins; Osteopontin; Phospholipids; Time Factors; Tumor Necrosis Factor-alpha; Xenobiotics | 2007 |
Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells.
Topics: Animals; beta Catenin; Cell Proliferation; Cells, Cultured; Dicarbethoxydihydrocollidine; Disease Models, Animal; Gene Expression Regulation; Hepatic Duct, Common; Liver; Liver Diseases; Mice; Mice, Transgenic; Signal Transduction; Stem Cells; TCF Transcription Factors; Wnt Proteins; Wnt3 Protein; Wnt3A Protein | 2007 |
Drug safety in porphyria.
Topics: Acute Disease; Animals; Dicarbethoxydihydrocollidine; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Humans; Porphyrias; Rats | 1980 |
Studies on the mechanism of experimental porphyria and ferrochelatase inhibition produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
Topics: Animals; Dicarbethoxydihydrocollidine; Disease Models, Animal; Dose-Response Relationship, Drug; Ferrochelatase; Liver; Lyases; Male; Mice; Microsomes, Liver; Mitochondria, Liver; Porphyrias; Pyridines; Rats; Species Specificity | 1980 |
Atypical ductular proliferation and its inhibition by transforming growth factor beta1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease.
Topics: Animals; Bile Ducts, Intrahepatic; Cell Division; Chemical and Drug Induced Liver Injury; Chronic Disease; Common Bile Duct; Dicarbethoxydihydrocollidine; Disease Models, Animal; Epithelial Cells; Hepatectomy; Ligation; Liver; Liver Diseases, Alcoholic; Liver Regeneration; Mice; Mice, Transgenic; Transforming Growth Factor beta | 1999 |
The effect of environmental light exposure on drug-induced porphyria in the rat.
Topics: Animals; Dicarbethoxydihydrocollidine; Disease Models, Animal; Heme; Light; Male; Porphyrias; Porphyrins; Rats; Skin | 1976 |
Porphyrinogenicity of etomidate and ketamine as continuous infusions. Screening in the DDC-primed rat model.
Topics: 5-Aminolevulinate Synthetase; Anesthesia, Intravenous; Animals; Dicarbethoxydihydrocollidine; Disease Models, Animal; Etomidate; Imidazoles; Ketamine; Liver; Male; Porphyrias; Porphyrins; Rats; Rats, Inbred Strains; Time Factors | 1985 |
TGF-β/YB-1/Atg7 axis promotes the proliferation of hepatic progenitor cells and liver fibrogenesis.
Topics: Animals; Autophagy; Autophagy-Related Protein 7; Cell Proliferation; Chemical and Drug Induced Liver Injury; Choline Deficiency; Disease Models, Animal; Ethionine; Extracellular Matrix; Gene Expression Regulation; Liver; Liver Cirrhosis; Mice, Knockout; Microscopy, Electron, Transmission; Pyridines; Stem Cells; Transcription Factors; Transforming Growth Factor beta | 2022 |
If It Looks Like a Duct and Acts Like a Duct: On the Role of Reprogrammed Hepatocytes in Cholangiopathies.
Topics: Animals; Bile; Bile Duct Diseases; Bile Ducts, Intrahepatic; Cell Transdifferentiation; Cellular Reprogramming; Cellular Reprogramming Techniques; Cholestasis, Intrahepatic; Disease Models, Animal; Epithelial Cells; Hepatocytes; Humans; Pyridines | 2020 |
N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease.
Topics: Acetylcysteine; Aging; Animals; Apoptosis; Disease Models, Animal; End Stage Liver Disease; Humans; Mice; Muscle Fibers, Skeletal; Muscular Atrophy; Oxidative Stress; Pyridines; Sarcopenia | 2019 |
A Novel Mouse Model of Acute-on-Chronic Cholestatic Alcoholic Liver Disease: A Systems Biology Comparison With Human Alcoholic Hepatitis.
Topics: Acute Disease; Animals; Cholestasis; Chronic Disease; Diet, High-Fat; Disease Models, Animal; Ethanol; Hepatitis, Alcoholic; Humans; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Pyridines; Systems Biology | 2020 |
Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy.
Topics: Action Potentials; Animals; Cardiomyopathies; Caveolin 3; Disease Models, Animal; Heart Rate; Isolated Heart Preparation; Liver Cirrhosis, Biliary; Male; Mice, Inbred C57BL; Mice, Transgenic; Myocardial Contraction; Myocardium; Pyridines; Signal Transduction; Time Factors; Up-Regulation | 2020 |
Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors.
Topics: Animals; Axin Protein; Bile Duct Diseases; Bile Ducts; Cell Polarity; Cholangitis, Sclerosing; Cicatrix; Disease Models, Animal; Epithelial Cells; Humans; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mice, Transgenic; Nerve Tissue Proteins; Pyridines; Wnt Signaling Pathway; Wnt-5a Protein | 2020 |
Intestinal Microbiome-Macrophage Crosstalk Contributes to Cholestatic Liver Disease by Promoting Intestinal Permeability in Mice.
Topics: Animals; Bile Acids and Salts; Cholestasis; Disease Models, Animal; Gastrointestinal Microbiome; Germ-Free Life; Humans; Inflammasomes; Intestinal Mucosa; Isocyanates; Liver; Liver Diseases; Macrophage Activation; Macrophages; Male; Mice; Naphthalenes; Permeability; Pyridines | 2020 |
Fine-scale visualizing the hierarchical structure of mouse biliary tree with fluorescence microscopy method.
Topics: Animals; Biliary Tract; Biliary Tract Diseases; Common Bile Duct; Disease Models, Animal; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Imaging, Three-Dimensional; Ligation; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Microscopy, Fluorescence; Pyridines; Receptors, Cell Surface; Rhodamines | 2020 |
Trehalose alleviates oxidative stress-mediated liver injury and Mallor-Denk body formation via activating autophagy in mice.
Topics: Administration, Oral; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Disease Models, Animal; Endoplasmic Reticulum Stress; Hepatocytes; Humans; Liver; Liver Diseases; Mallory Bodies; Mice; Oxidative Stress; Pyridines; Trehalose | 2021 |
MiR-451a ameliorates alcoholic hepatitis via repressing HDAC8-mediated proinflammatory response.
Topics: Animals; Base Pairing; Base Sequence; Cell Line; Cell Proliferation; Databases, Genetic; Disease Models, Animal; Gene Expression Regulation; Genetic Vectors; Hepatitis, Alcoholic; Hepatocytes; Histone Deacetylases; Humans; Inflammation; Lentivirus; Liver; Mice; Mice, Inbred C57BL; MicroRNAs; Oligoribonucleotides; Pyridines; Signal Transduction | 2020 |
Epigenomic Evaluation of Cholangiocyte Transforming Growth Factor-β Signaling Identifies a Selective Role for Histone 3 Lysine 9 Acetylation in Biliary Fibrosis.
Topics: Acetylation; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Bile Ducts; Cell Line; Chromatin Immunoprecipitation Sequencing; Disease Models, Animal; Epigenesis, Genetic; Epigenomics; Gene Knockdown Techniques; Histone Acetyltransferases; Histones; Humans; Liver Cirrhosis, Biliary; Mice; Mice, Knockout; Myofibroblasts; Primary Cell Culture; Pyridines; RNA-Seq; Signal Transduction; Transforming Growth Factor beta | 2021 |
Time-series metabolomics insights into the progressive characteristics of 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestatic liver fibrosis in mice.
Topics: Animals; Cholestasis; Disease Models, Animal; Liver; Liver Cirrhosis; Metabolomics; Mice; Mice, Inbred C57BL; Pyridines | 2021 |
A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin-4 in Tumor Progression.
Topics: Animals; Bile Duct Neoplasms; Carcinoma, Ductal; Carcinoma, Papillary; Cholangiocarcinoma; Cholangitis; Disease Models, Animal; HMGB Proteins; Liver Neoplasms, Experimental; Mice; Proto-Oncogene Proteins p21(ras); Pyridines; Signal Transduction; SOXF Transcription Factors; Tensins | 2021 |
Mouse Models of Liver Fibrosis.
Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Mice; Mice, Inbred BALB C; Pyridines; Thioacetamide | 2021 |
Indole-3-Carboxaldehyde Restores Gut Mucosal Integrity and Protects from Liver Fibrosis in Murine Sclerosing Cholangitis.
Topics: Animals; Cholangitis, Sclerosing; Diet; Disease Models, Animal; Indoles; Inflammation; Interleukin-22; Interleukins; Intestinal Mucosa; Liver Cirrhosis; Mice, Inbred C57BL; Microbiota; Pyridines; Receptors, Aryl Hydrocarbon | 2021 |
Pivotal roles of Kupffer cells in the progression and regression of DDC-induced chronic cholangiopathy.
Topics: Animals; Bile Duct Diseases; Disease Models, Animal; Disease Progression; Glycogen; Humans; Inflammation; Kupffer Cells; Liver; Mice; Phenotype; Pyridines; Splenomegaly | 2018 |
Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system.
Topics: Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury, Chronic; Circadian Rhythm; CLOCK Proteins; Disease Models, Animal; Epithelial Cell Adhesion Molecule; Hepatocytes; Lymphoid Enhancer-Binding Factor 1; Mice, Inbred ICR; Mutation; Pyridines; Stem Cells; Transcription Factor 4; Transcriptional Activation | 2018 |
Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice.
Topics: Animals; Bile; Biological Transport; Chemical and Drug Induced Liver Injury, Chronic; Choline Deficiency; Claudins; Disease Models, Animal; Ethionine; Hepatocytes; Kinetics; Liver; Membrane Transport Proteins; Mice, Inbred C57BL; Permeability; Pyridines; Tight Junctions | 2018 |
The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity.
Topics: Animals; Disease Models, Animal; Down-Regulation; Fatty Liver; Fenofibrate; Humans; Male; Mallory Bodies; Mice; Oxidative Stress; PPAR alpha; Protein Aggregates; Pyridines | 2018 |
Conversion of Fibroblasts to Hepatocyte-Like Cells In Vivo.
Topics: Animals; Carbon Tetrachloride; Cell Lineage; Cellular Reprogramming; Dependovirus; Disease Models, Animal; Fibroblasts; GATA4 Transcription Factor; Genetic Vectors; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 3-gamma; Hepatocyte Nuclear Factor 4; Hepatocytes; Humans; Liver Cirrhosis; Mice; Pyridines; Transcription Factors | 2019 |
3,5-Diethoxycarbonyl-1,4-Dihydrocollidine Diet: A Rodent Model in Cholestasis Research.
Topics: Animals; Cholestasis; Disease Models, Animal; Immunohistochemistry; Keratin-19; Liver Cirrhosis, Biliary; Mice; Pyridines | 2019 |
Identification of global mRNA expression profiles and comprehensive bioinformatic analyses of abnormally expressed genes in cholestatic liver disease.
Topics: Animals; Bile Ducts; Cholestasis, Intrahepatic; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Gene Regulatory Networks; Humans; Mice; Protein Interaction Maps; Pyridines; Sequence Analysis, RNA | 2019 |
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Cell Proliferation; Cell Self Renewal; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Epithelial Cells; Female; Hepatocytes; Homeostasis; Humans; Liver; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridines; Signal Transduction; Single-Cell Analysis; YAP-Signaling Proteins | 2019 |
YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury.
Topics: Acute Lung Injury; Adaptor Proteins, Signal Transducing; Animals; Axin Protein; Bile Ducts; Cell Cycle Proteins; Cells, Cultured; Clustered Regularly Interspaced Short Palindromic Repeats; Disease Models, Animal; Epithelial Cells; Humans; Induced Pluripotent Stem Cells; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Pyridines; Receptors, G-Protein-Coupled; Thrombospondins; Wnt Signaling Pathway; YAP-Signaling Proteins | 2019 |
Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis.
Topics: Animals; Antigens, CD; Apyrase; Cholangitis, Sclerosing; Disease Models, Animal; Liver Cirrhosis; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridines | 2019 |
Lamin aggregation is an early sensor of porphyria-induced liver injury.
Topics: Animals; Disease Models, Animal; Fatty Liver; Ferrochelatase; GTP-Binding Proteins; Hep G2 Cells; Humans; Lamin Type A; Lamin Type B; Mallory Bodies; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation; Oxidative Stress; Porphyrias, Hepatic; Protein Glutamine gamma Glutamyltransferase 2; Protein Multimerization; Protein Transport; Protoporphyrins; Pyridines; Transglutaminases | 2013 |
Cardiomyopathy reverses with recovery of liver injury, cholestasis and cholanemia in mouse model of biliary fibrosis.
Topics: Adrenergic beta-Agonists; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biomarkers; Cardiomyopathies; Cholestasis; Cholic Acid; Disease Models, Animal; Drug Resistance; Liver; Liver Cirrhosis, Biliary; Male; Mice, Inbred C57BL; Mice, Knockout; Pyridines; Recovery of Function; Signal Transduction; Time Factors; Ventricular Function, Left | 2015 |
Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver.
Topics: Albumins; Animals; Basic Helix-Loop-Helix Transcription Factors; Bile Ducts; Cell Count; Cell Lineage; Chronic Disease; Disease Models, Animal; Hepatocyte Nuclear Factor 4; Hepatocytes; Homeodomain Proteins; Liver; Liver Failure, Acute; Liver Regeneration; Mice, Inbred C57BL; Pyridines; Receptors, Notch; Signal Transduction; Transcription Factor HES-1 | 2014 |
Sensitivity and specificity of in situ proximity ligation for protein interaction analysis in a model of steatohepatitis with Mallory-Denk bodies.
Topics: Animals; Cytoplasm; Disease Models, Animal; Fatty Liver; Genetic Techniques; Hepatocytes; Keratins; Liver; Male; Mallory Bodies; Mice; Mice, Transgenic; Microscopy, Fluorescence; Protein Interaction Mapping; Protein Processing, Post-Translational; Pyridines; Reproducibility of Results; Transcription Factor TFIIH; Transcription Factors | 2014 |
Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Biomarkers; Carbamoyl-Phosphate Synthase (Ammonia); Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Culture Media, Conditioned; Disease Models, Animal; Fas Ligand Protein; Half-Life; Hepatitis B, Chronic; Hepatitis C, Chronic; Hepatocytes; Humans; Liver; Mice; Necrosis; Prognosis; Pyridines; Time Factors | 2014 |
Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury.
Topics: Animals; Bacterial Proteins; Bile Ducts, Intrahepatic; Cell Death; Cell Lineage; Cell Proliferation; Chemical and Drug Induced Liver Injury; Choline Deficiency; Disease Models, Animal; DNA Damage; Ethionine; Female; Forkhead Transcription Factors; Heparin-binding EGF-like Growth Factor; Hepatocytes; Integrases; Liver; Liver Regeneration; Luminescent Proteins; Male; Mice, Knockout; Oxidative Stress; Pyridines; RNA, Untranslated; Signal Transduction; Stem Cells; Time Factors | 2015 |
Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains.
Topics: Animals; Cluster Analysis; Disease Models, Animal; Fatty Liver; Gene Expression Profiling; Gene Expression Regulation; Metabolic Networks and Pathways; Metabolome; Metabolomics; Mice; Non-alcoholic Fatty Liver Disease; Phenotype; Proteomics; Pyridines; Severity of Illness Index; Signal Transduction | 2014 |
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cyclin D1; Diethylnitrosamine; Disease Models, Animal; Hepatocytes; Hydrogen Peroxide; Inflammation; Interleukin-6; Liver; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Non-alcoholic Fatty Liver Disease; Pyridines; Tumor Necrosis Factor-alpha | 2015 |
Loss of keratin 19 favours the development of cholestatic liver disease through decreased ductular reaction.
Topics: Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cholangitis, Sclerosing; Cholestasis, Extrahepatic; Cholic Acid; Choline Deficiency; Common Bile Duct; Disease Models, Animal; Epithelial Cells; Ethionine; Keratin-19; Ligation; Liver; Liver Cirrhosis, Biliary; Liver Regeneration; Male; Mice, Knockout; Phenotype; Pyridines; Signal Transduction; Stem Cells; Time Factors | 2015 |
Renal Impairment with Sublethal Tubular Cell Injury in a Chronic Liver Disease Mouse Model.
Topics: Animals; Apoptosis; Chronic Disease; Collagen; Disease Models, Animal; Disease Progression; Immunohistochemistry; Inflammation; Kidney; Kidney Diseases; Kidney Tubules; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Oxidative Stress; Pyridines | 2016 |
Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinogens; Cell Communication; Cell Dedifferentiation; Cholangiocarcinoma; Clodronic Acid; Disease Models, Animal; Gene Expression Regulation; Hepatocytes; Humans; Jagged-1 Protein; Kupffer Cells; Mice; Mice, Inbred C57BL; Pyridines; Receptor, Notch1; Signal Transduction; Survival Analysis; Thioacetamide | 2016 |
Foxl1 is a marker of bipotential hepatic progenitor cells in mice.
Topics: Animals; Bile Ducts, Intrahepatic; Biomarkers; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Epithelial Cells; Female; Forkhead Transcription Factors; Hepatocyte Nuclear Factor 4; Hepatocytes; Keratin-19; Ligation; Liver; Liver Diseases; Male; Mesenchymal Stem Cells; Mice; Mice, Transgenic; Pyridines | 2009 |
Spontaneous repopulation of β-catenin null livers with β-catenin-positive hepatocytes after chronic murine liver injury.
Topics: Animals; beta Catenin; Blotting, Western; Cells, Cultured; Chemical and Drug Induced Liver Injury, Chronic; Chronic Disease; Disease Models, Animal; Hepatocytes; Immunohistochemistry; Liver Function Tests; Liver Regeneration; Mice; Mice, Knockout; Pyridines; Random Allocation; Real-Time Polymerase Chain Reaction | 2011 |
The establishment and characterization of immortal hepatocyte cell lines from a mouse liver injury model.
Topics: Albumins; Animals; Cell Line; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glucose-6-Phosphatase; Glycogen; Hepatocytes; Lipids; Liver; Male; Mice; Pyridines; Urea | 2011 |
Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cholangiocarcinoma; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Middle Aged; Pyridines; Signal Transduction; Stem Cells; Trans-Activators; Viral Regulatory and Accessory Proteins | 2012 |
Hepatocyte growth factor/c-met signaling is required for stem-cell-mediated liver regeneration in mice.
Topics: Animals; Cell Differentiation; Cell Movement; Chemical and Drug Induced Liver Injury; Chemokine CXCL12; Disease Models, Animal; Hepatocyte Growth Factor; Liver Regeneration; Male; Matrix Metalloproteinase 9; Mice; Mice, Mutant Strains; Mice, Transgenic; Proto-Oncogene Proteins c-met; Pyridines; Signal Transduction; Stem Cell Transplantation; Stem Cells | 2012 |
Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, Animal; Fatty Liver; Female; Gene Expression; Genetic Predisposition to Disease; Keratin-18; Keratin-8; Liver; Male; Mallory Bodies; Mice; Mice, Knockout; Organ Size; Proteins; Pyridines | 2012 |
CFTR dysfunction predisposes to fibrotic liver disease in a murine model.
Topics: Animals; Bile Ducts; Biomarkers; Colitis; Cystic Fibrosis; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation; Immunohistochemistry; Liver; Liver Cirrhosis; Mice; Mice, Inbred CFTR; Pyridines; RNA, Messenger; Staining and Labeling; Transcription, Genetic | 2012 |
Bile canalicular abnormalities in the early phase of a mouse model of sclerosing cholangitis.
Topics: Animals; Bile Canaliculi; Bile Ducts, Intrahepatic; Cholangitis, Sclerosing; Disease Models, Animal; Disease Progression; Liver; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron; Pyridines | 2013 |
Alterations of the redox state, pentose pathway and glutathione metabolism in an acute porphyria model. Their impact on heme pathway.
Topics: Allylisopropylacetamide; Animals; Disease Models, Animal; Glucose; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Heme; Liver; NADP; Oxidation-Reduction; Oxidative Stress; Pentose Phosphate Pathway; Porphyria, Acute Intermittent; Pyridines; Rats; Reactive Oxygen Species | 2013 |
SAMe prevents the up regulation of toll-like receptor signaling in Mallory-Denk body forming hepatocytes.
Topics: Animals; Base Sequence; Dihydropyridines; Disease Models, Animal; DNA Primers; Hepatocytes; Humans; Inclusion Bodies; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred C3H; Myeloid Differentiation Factor 88; S-Adenosylmethionine; Signal Transduction; TNF Receptor-Associated Factor 6; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptors; Up-Regulation | 2010 |
SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model.
Topics: Animals; Base Sequence; Cysteine Endopeptidases; Dihydropyridines; Disease Models, Animal; DNA Primers; Gene Expression; Inclusion Bodies; Keratins; Liver; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred C3H; Multienzyme Complexes; Proteasome Endopeptidase Complex; S-Adenosylmethionine; Ubiquitin; Ubiquitins | 2010 |
Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis.
Topics: Animals; Carcinogens; Cells, Cultured; Dihydropyridines; Disease Models, Animal; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Hepatocytes; Hydroxamic Acids; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Oligonucleotide Array Sequence Analysis; Precancerous Conditions; Proteins; Ubiquitins; Up-Regulation | 2008 |