dibutyryl-cyclic-gmp has been researched along with Seizures* in 5 studies
5 other study(ies) available for dibutyryl-cyclic-gmp and Seizures
| Article | Year |
|---|---|
Cerebellar cyclic nucleotides and the development of convulsion, with reference to the anticonvulsant activity of diazepam.
Dibutyryl cyclic GMP (DbcGMP) or dibutyryl cyclic AMP (DbcAMP) given to rats intracerebellarly in a dose of 200 nmol/head produced electroencephalographic convulsive changes. Intracerebellar (i.c.) administration of lower doses (100 nmol/head) of DbcGMP and DbcAMP and 200 nmol/head of norepinephrine (NE) and glutamate (Glu) facilitated the pentylenetetrazol (PTZ)-induced convulsions. Diazepam (100 nmol/head, i.c.) suppressed the PTZ-induced convulsions. GABA (400 nmol/head, i.c.) did not affect the PTZ-induced convulsions. These results suggest that DbcGMP, DbcAMP and Glu inhibit seizure control mechanisms in the cerebellum, and that one of the sites of the anticonvulsant action of diazepam is located in the cerebellum. Topics: Animals; Anticonvulsants; Bucladesine; Cerebellum; Diazepam; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Electroencephalography; gamma-Aminobutyric Acid; Male; Nucleotides, Cyclic; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1986 |
Brain cyclic nucleotides and the development of convulsion, with reference to the anticonvulsant activity of diazepam.
Dibutyryl cyclic GMP (DbcGMP) or dibutyryl cyclic AMP (DbcAMP) given to mice intracerebroventricularly in a dose of 200 or 400 nmol/head produced electroencephalographic and electromyographic changes corresponding to twitches, and clonic and tonic convulsions. Lower doses of DbcGMP or DbcAMP facilitated the pentylenetetrazol-induced clonic and tonic convulsions. Diazepam given intraperitoneally in a dose of 0.5 mg/kg suppressed clonic and tonic convulsions induced by DbcGMP and DbcAMP, but the twitches were not suppressed. These results suggest that these nucleotides lower the threshold for electrical discharges related to convulsion and facilitate the propagation of convulsion. Diazepam suppresses this facilitation. Topics: Animals; Anticonvulsants; Brain; Bucladesine; Cyclic AMP; Cyclic GMP; Diazepam; Dibutyryl Cyclic GMP; Electroencephalography; Electromyography; Female; Mice; Mice, Inbred ICR; Nucleotides, Cyclic; Pentylenetetrazole; Seizures | 1984 |
Modification of cholinergically induced convulsive activity and cyclic GMP levels in the CNS.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Central Nervous System; Cerebellum; Cholinesterase Inhibitors; Clonazepam; Cyclic GMP; Dibutyryl Cyclic GMP; Lethal Dose 50; Male; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Seizures; Soman | 1983 |
Interactions between cholinergic drugs, gamma-aminobutyric acid and cyclic guanosine monophosphate on picrotoxin-induced convulsive-seizure threshold.
Topics: Animals; Cyclic GMP; Dibutyryl Cyclic GMP; Drug Interactions; gamma-Aminobutyric Acid; Mice; Oxotremorine; Parasympathomimetics; Picrotoxin; Seizures | 1981 |
Cyclic nucleotide metabolism in mouse brain during seizures induced by bicuculline or dibutyryl cyclic guanosine monophosphate.
Topics: Animals; Bicuculline; Brain; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Male; Mice; Mice, Inbred C57BL; Seizures | 1980 |