dibutyltin-dilaurate and Poultry-Diseases

Two trials were conducted to compare the efficacy of currently approved anticoccidials for turkeys against challenge using a field isolate of mixed Eimeria species; E. adenoides, E. gallopavonis, and E. meleagrimitis. Poults in wire-floored cages were fed unmedicated diets from day-old to 3 wk of age. Diets were supplemented with either amprolium (AMP, 125 mg/kg), butynorate (BUT, 375 mg/kg), monensin (MON-60, 60 mg/kg; MON-100, 100 mg/kg), halofuginone (HAL; 3 mg/kg), zoalene (ZOA; 125 mg/kg), or sulfadimethoxine plus ormetoprim (SUL + ORM, 62.5 mg/kg and 37.5 mg/kg, respectively). After 2 days on the test diets, poults were individually weighed and inoculated with sporulated coccidial oocysts from the field isolate. Total fecal collections were obtained for Days 0 to 5 and 6 to 10 to estimate oocyst output. At 10 days postinoculation, the birds were individually weighed and killed to determine severity of intestinal lesions. The HAL and MON were most effective and AMP, ZOA, and SUL + ORM were least effective in maintaining weight and in reducing the severity of intestinal lesions. All the coccidiostats tested reduced oocyst passage, but poults fed HAL produced fewer oocysts. The results demonstrated differences in efficacy among anticoccidials with the more recently approved drugs providing the best protection against coccidiosis.

Topics: Amprolium; Animals; Coccidiosis; Coccidiostats; Dinitolmide; Feces; Intestines; Male; Monensin; Organotin Compounds; Piperidines; Poultry Diseases; Pyrimidines; Quinazolines; Quinazolinones; Sulfadimethoxine; Turkeys; Weight Gain

Poisoning caused by dibutyltin dilaurate (DBTD) was diagnosed in cattle, mink, and palm doves. The accidental addition of a DBTD premix to calf concentrates at levels up to 25000 ppm on 18 farms caused poisoning in 1000 cattle, of which 171 died and 287 were slaughtered. High concentrations of tin were found in the cattle tissues and precluded their consumption by humans. Palm doves ingesting concentrates containing 12500 ppm DBTD on one farm were also poisoned and had high concentrations of tin in tissues. Mink were inadvertently fed a vitamin-mineral supplement containing about 1700 ppm DBTD. They appeared the most suceptible of the three species to this compound.

Topics: Animal Feed; Animals; Cattle; Cattle Diseases; Coccidiostats; Female; Food Contamination; Male; Mink; Organotin Compounds; Poultry; Poultry Diseases; Tissue Distribution