dibutyltin-dilaurate and Body-Weight

Topics: Age Factors; Animals; Body Weight; Disease Models, Animal; Female; Learning; Male; Motor Activity; Organotin Compounds; Rats; Sex Characteristics; Survival Rate

Administration of dibutyltin dilaurate (DBTL; 0, 20 or 40 mg/kg body wt.) by gavage to rats for 3 consecutive days produced a significant increase in polyamine levels in selected brain areas. At the higher dose of DBTL (40 mg/kg) spermidine levels were raised in pons-medulla, hypothalamus and frontal cortex while spermine levels increased in pons-medulla, hippocampus and frontal cortex regions. At the lower dose (20 mg/kg) only a slight increase in polyamine levels occurred. The observed induction in regional brain polyamines in DBTL-treated rats may lead to disturbances in synaptic function and further enhance its neurotoxic potential.

Topics: Animals; Anthelmintics; Body Weight; Brain; Female; Organotin Compounds; Rats; Rats, Inbred Strains; Spermidine; Spermine

Four feeding trials were conducted in which Large White turkeys were fed diets containing either amprolium or butynorate to 8 or 9 weeks of age to female and male turkeys, respectively. Diets fed during the study contained from 0 to 10% supplemental fat to provide a range of dietary energy levels. Poults were maintained on built-up wood shavings litter with no attempts to induce coccidiosis. Turkeys fed diets with amprolium did not grow as well or convert feed as efficiently as those fed butynorate at 8 or 9 weeks of age when the additives were withdrawn. However, at market weights or feed utilization between turkeys fed the two different anticoccidials.

Topics: Amprolium; Animal Feed; Animals; Body Weight; Coccidiostats; Energy Metabolism; Female; Food Additives; Male; Organotin Compounds; Picolines; Turkeys

Toxicological studies of a leachable stabilizer Di-n-butyltin dilaurate (DBTL) were undertaken. Effects of DBTL after 15 days oral exposure to rats were studied on brain and liver enzyme activities. A significant decrease in body weight gain of DBTL exposed rats were observed. No effect was observed in the activities of brain enzymes, succinic dehydrogenase, adenosine triphosphatase, acetylcholine esterase and monoamine oxidase. In liver, DBTL treatment resulted in a significant decrease in the activities of microsomal enzymes glucose-6-phosphatase, aminopyrine-N-demethylase, benzphetamine-N-demethylase, aniline hydroxylase, benzo(a)pyrene hydroxylase and also on cytochrome P-450 content, whereas no difference in the activities of mitochondrial enzymes, succinic dehydrogenase, Mg2+-adenosine triphosphatase as well as in the activity of lysosomal enzyme acid phosphatase was observed. Duration of exposure dependent increase in pentabarbital induced sleeping time was also observed. DBTL treatment produced an induction in heme oxygenase activity whereas the activity of -aminolevulinic acid synthetase remained unaltered. The results demonstrate that DBTL significantly affects the biotransformation mechanism and heme metabolism of hepatocytes.

Topics: Animals; Body Weight; Brain; Cytochrome P-450 Enzyme System; Laurates; Lauric Acids; Lethal Dose 50; Liver; Male; Mitochondria, Liver; Mixed Function Oxygenases; Organotin Compounds; Oxidoreductases; Pentobarbital; Rats