dibutyl phthalate has been researched along with Pregnancy in 193 studies
Dibutyl Phthalate: A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.
dibutyl phthalate : A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to investigate the mechanism of dibutyl phthalate (DBP) induced hypospadias and shortened anogenital distance (AGD)." | 7.81 | The mechanism underlying dibutyl phthalate induced shortened anogenital distance and hypospadias in rats. ( Chen, X; Feng, J; Li, N; Yuan, J; Zhang, W; Zhou, X, 2015) |
| " Mesalamine is considered safe in pregnancy, excluding formulations with dibutyl phthalate." | 5.05 | Mesalamine in the Initial Therapy of Ulcerative Colitis. ( Chibbar, R; Moss, AC, 2020) |
| "The purpose of this study was to investigate the mechanism of dibutyl phthalate (DBP) induced hypospadias and shortened anogenital distance (AGD)." | 3.81 | The mechanism underlying dibutyl phthalate induced shortened anogenital distance and hypospadias in rats. ( Chen, X; Feng, J; Li, N; Yuan, J; Zhang, W; Zhou, X, 2015) |
| " However, the current study demonstrates that oral administration of dibutyl phthalate (DBP) to female Long Evans (LE) hooded rats from weaning, through puberty, mating, and gestation disrupts pregnancy maintenance at dose levels similar to those that affect testis function in male rats." | 3.73 | Chronic di-n-butyl phthalate exposure in rats reduces fertility and alters ovarian function during pregnancy in female Long Evans hooded rats. ( Gray, LE; Laskey, J; Ostby, J, 2006) |
| "Two studies were designed to examine amniotic fluid and maternal urine concentrations of the di(2-ethylhexyl) phthalate (DEHP) metabolite mono(2-ethylhexyl) phthalate (MEHP) and the di-n-butyl phthalate (DBP) metabolite monobutyl phthalate (MBP) after administration of DEHP and DBP during pregnancy." | 3.73 | Urinary and amniotic fluid levels of phthalate monoesters in rats after the oral administration of di(2-ethylhexyl) phthalate and di-n-butyl phthalate. ( Barr, DB; Brock, JW; Calafat, AM; Gray, LE; Needham, LL; Reidy, JA; Silva, MJ, 2006) |
| " Additionally, lower doses cause more adverse effects than the highest dose, which is an important fact because of the widespread environmental exposure to DBP." | 2.72 | The overview of current evidence on the reproductive toxicity of dibutyl phthalate. ( Czerczak, S; Czubacka, E; Kupczewska-Dobecka, MM, 2021) |
| " In all binary mixture studies, rats were dosed during pregnancy with chemicals, singly or in pairs, at dosage levels equivalent to approximately one-half of the ED50 for hypospadias or epididymal agenesis." | 2.46 | Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity. ( Furr, JR; Gray, LE; Rider, CV; Wilson, VS, 2010) |
| " Rats were dosed during pregnancy with antiandrogens singly or in pairs at dosage levels equivalent to about one half of the ED50 for hypospadias or epididymal agenesis." | 2.45 | Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development. ( Furr, JR; Gray, LE; Hotchkiss, AK; Howdeshell, KL; Lambright, CR; Rider, CV; Wilson, VS, 2009) |
| " In a study conducted at CIIT, the majority of these adverse changes could be reproduced over a similar dose range, but with a much shorter dosing regimen covering a critical window of development (gestation days 12-20)." | 2.41 | Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat: implications for human risk assessment. ( Cattley, RC; Foster, PM; Mylchreest, E, 2000) |
| "The dibutyl phthalate (DBP) has been detected in fetuses and infants and can cause damage to the reproductive system in adulthood, but the exact mechanism remains unclear." | 1.91 | DNA methylation-mediated inhibition of MGARP is involved in impaired progeny testosterone synthesis in mice exposed to DBP in utero. ( Feng, X; Jiang, Y; Li, H; Liu, M; Sun, X; Wang, H; Xu, X; Yu, J; Yu, Y; Zhang, J, 2023) |
| " Rats were orally dosed from gestation days 14-18 with dilutions of PFQ and DBP at 0%, 12." | 1.72 | In Utero Exposure to a Mixture of the Perfluoroalkyl-Isopropyl Pesticide Pyrifluquinazon With Dibutyl Phthalate Cumulatively Disrupts Male Rat Reproductive Development via Different Mechanisms of Action. ( Conley, JM; Furr, JR; Gray, LE; Lambright, CS, 2022) |
| "Hypospadias and cryptorchidism are the most common congenital malformations in male neonates, both of which are also the important clinical manifestations of testicular dysgenesis syndrome and share a same origin." | 1.72 | Identification of endocrine-disrupting chemicals targeting the genes and pathways of genital anomalies in males. ( Abulimiti, G; Cong, R; Ji, C; Luan, J; Song, N; Wang, Y; Yang, J; Yao, L; Zhang, Q; Zhang, X; Zhou, X, 2022) |
| "Dibutyl phthalate (DBP) is an endocrine disruptor, which causes male reproductive dysfunction in rodents." | 1.72 | Preconception exposure to dibutyl phthalate (DBP) impairs spermatogenesis by activating NF-κB/COX-2/RANKL signaling in Sertoli cells. ( Hua, S; Jiang, J; Liu, S; Shi, F; Wu, L; Xie, Z; Zhang, Y; Zhu, Y, 2022) |
| "Dibutyl phthalate (DBP) was used at a high dose level (750 mg/kg bw/day) as an established positive control substance for anti-androgenic effects on the developing male reproductive tract." | 1.56 | Systematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window. ( Inglis, F; Langsch, A; Otter, R; Palermo, C; Shoker, S; van den Driesche, S, 2020) |
| "The prevalence of language delay was 10." | 1.48 | Association of Prenatal Phthalate Exposure With Language Development in Early Childhood. ( Barrett, ES; Bornehag, CG; Bush, NR; Evans, SF; Lindh, C; Nguyen, RHN; Reichenberg, A; Sathyanarayana, S; Swan, SH; Unenge Hallerback, M; Wikström, S, 2018) |
| " Pregnant CD-1 dams were orally dosed with vehicle (tocopherol-stripped corn oil) or a phthalate mixture (20 and 200 µg/kg/d, 200 and 500 mg/kg/d) daily from gestational day 10 to birth." | 1.46 | Exposure to an Environmentally Relevant Phthalate Mixture Causes Transgenerational Effects on Female Reproduction in Mice. ( Flaws, JA; Gao, L; Zhou, C, 2017) |
| " Therefore, long-term exposure to phthalate esters affected development and function of the primate testis in a time and dosage dependent manner." | 1.40 | Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice. ( Alpaugh, W; Avelar, GF; Bondareva, A; Conley, A; Coyle, KM; Dobrinski, I; França, LR; Meyers, S; Modelski, M; Rodriguez-Sosa, JR; Tang, L; Wynne-Edwards, K, 2014) |
| "While the frequency of undescended testes after 200 mg/kg DBP exposure in the orl strain appeared increased, these data were not statistically significant." | 1.35 | The orl rat with inherited cryptorchidism has increased susceptibility to the testicular effects of in utero dibutyl phthalate exposure. ( Barthold, JS; Campion, L; Herrmann, R; Johnson, KJ; McCahan, SM; Si, X, 2008) |
| " In order to gain a better understanding of the effect of repeated dosing on maternal and fetal metabolism and distribution, pregnant Sprague-Dawley rats were given a single dose of 500 mg/kg DBP on GD 19 or daily doses of 50, 100, and 500 mg/(kg day) from GD 12 to 19 via corn oil gavage." | 1.35 | Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats. ( Andersen, ME; Borghoff, SJ; Campbell, JL; Clewell, RA; Kremer, JJ; Sochaski, MA; Williams, CC, 2009) |
| " Overall, the dose level of DBP in the present study produced a few adverse effects on the neurobehavioral parameters, and it may alter cognitive abilities of the male rodent." | 1.35 | Neurobehavioral toxicity study of dibutyl phthalate on rats following in utero and lactational exposure. ( Li, T; Li, Y; Shi, N; Zhuang, M, 2009) |
| " Monobutyl phthalate, the developmentally toxic metabolite of DBP, and its glucuronide conjugate were found in maternal and fetal plasma, amniotic fluid, and maternal urine." | 1.35 | Reproductive toxicity and pharmacokinetics of di-n-butyl phthalate (DBP) following dietary exposure of pregnant rats. ( Dorman, DC; Gaido, KW; Hensley, JB; Lehmann, KP; Ross, SM; Sochaski, MA; Struve, MF; Willson, GA, 2009) |
| " We characterized the dose-response effects of six individual phthalates (BBP, DBP, DEHP, diethyl phthalate [DEP], diisobutyl phthalate [DiBP], and dipentyl phthalate [DPP]) on gestation day (GD) 18 testicular testosterone production following exposure of Sprague-Dawley rats on GD 8-18." | 1.35 | A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner. ( Blystone, CR; Furr, J; Gray, LE; Hotchkiss, AK; Howdeshell, KL; Lambright, CR; Rider, CV; Wilson, VS, 2008) |
| " With exposed dose increasing, the serum testosterone (T) levels of male rats inversely decreased, and in the same dosage group the serum T levels of hypospadiac rats were significantly lower than the levels of nonhypospadiac counterparts." | 1.34 | Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP). ( Jiang, J; Ma, L; Wang, X; Yuan, L; Zhang, W, 2007) |
| " Pregnant rats and neonatal male marmosets were dosed with 500 mg/kg/day DBP or MBP." | 1.34 | Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human. ( Anderson, RA; Bayne, R; Coutts, S; Greig, I; Hallmark, N; Mahood, IK; McKinnell, C; Morris, K; Scott, H; Sharpe, RM; Walker, M, 2007) |
| "Cryptorchidism is a common reproductive abnormality, possibly resulting from abnormal hormone production/action by the fetal testis." | 1.33 | Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate. ( Haag, F; Hallmark, N; Hartung, S; Ivell, R; Jégou, B; Koch-Nolte, F; Mahood, K; McKinnell, C; Scott, H; Sharpe, RM; Staub, C, 2005) |
| "Diisobutyl phthalate (DiBP) has similar structural and application properties as DBP, and is being used as a substitute for DBP." | 1.33 | Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis. ( Axelstad, M; Borch, J; Dalgaard, M; Vinggaard, AM, 2006) |
| " In conclusion, DIBP administered by gavage is embryotoxic and teratogenic, and affects the developing male reproductive tract, at maternal toxic doses." | 1.33 | Developmental toxic effects of diisobutyl phthalate, the methyl-branched analogue of di-n-butyl phthalate, administered by gavage to rats. ( Gallissot, F; Sabaté, JP; Saillenfait, AM, 2006) |
| " Pregnant Sprague-Dawley rats were orally dosed with DBP at levels of 10, 50, or 500 mg/kg/day from gestation days 12 to 19; maternal and fetal liver samples were collected on day 19 for analyses." | 1.33 | Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses. ( Bartolucci-Page, E; Gaido, KW; Hoffman, HB; Kirwan, SE; Laughter, A; Wyde, ME; Yan, B; You, L; Zhang, F, 2005) |
| "Timed-pregnant Sprague-Dawley rats were dosed with DBP at 500 mg/kg/day on gestation day (GD) 14 and 15, 15 and 16, 16 and 17, 17 and 18, 18 and 19, or 19 and 20 (GD 0=plug day)." | 1.33 | Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate. ( Carruthers, CM; Foster, PM, 2005) |
| ") dosing with MBP." | 1.33 | Pharmacokinetics of monobutylphthalate, the active metabolite of di-n-butylphthalate, in pregnant rats. ( Borghoff, SJ; Kremer, JJ; Parkinson, HD; Williams, CC, 2005) |
| " The NOAEL (no observable adverse effect level) for developmental toxicity of DBP was established based on pup body weight and male reproductive lesions at 50 mg/kg BW/day." | 1.32 | Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL. ( Chen, B; Jiang, X; Zhang, Y, 2004) |
| " To determine the dose-response relationship for the effect of DBP on steroidogenesis in fetal rat testes, pregnant Sprague-Dawley rats received corn oil (vehicle control) or DBP (0." | 1.32 | Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. ( Foster, PM; Gaido, KW; Lehmann, KP; Phillips, S; Sar, M, 2004) |
| " In another experiment, pregnant dams were treated with DBP until gd 19, with the start of DBP treatment moved 1 d later into gestation for each treatment group, with the final group dosed only on gd 19." | 1.32 | Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism. ( Gaido, KW; Ross, SM; Thompson, CJ, 2004) |
| "The objective of this study was to determine the susceptible days for the adverse effects of di-n-butyl phthalate (DBP) on development of reproductive system in male offspring following maternal administration on successive 3-day period during late pregnancy." | 1.31 | Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy. ( Ema, M; Kawashima, K; Miyawaki, E, 2000) |
| " Since previous, limited dose-response studies with DBP that reported alterations in male reproductive development and function failed to establish a NOAEL (no-observed-adverse-effect level), an extensive dose-response study was conducted." | 1.31 | Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation. ( Cattley, RC; Foster, PM; Mylchreest, E; Wallace, DG, 2000) |
| "Linuron, which is a weak competitive inhibitor of AR binding (reported Ki of 100 microM), alters sexual differentiation in an antiandrogenic manner." | 1.31 | Cellular and molecular mechanisms of action of linuron: an antiandrogenic herbicide that produces reproductive malformations in male rats. ( Bobseine, K; Gray, LE; Hotchkiss, AK; Lambright, C; Mann, PC; Ostby, J; Wilson, V, 2000) |
| " In the developmental toxicity study, dams were dosed with 0, 0." | 1.30 | Assessment of the developmental toxicity, metabolism, and placental transfer of Di-n-butyl phthalate administered to pregnant rats. ( Beydon, D; Fabry, JP; Gallissot, F; Langonne, I; Payan, JP; Sabate, JP; Saillenfait, AM, 1998) |
| "0% DBP in the diet were selected, and this dosing design yielded average daily DBP intakes of 52, 256, and 509 mg/kg for males and 80, 385, and 794 mg/kg for females, respectively." | 1.30 | Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats. ( Barnes, LH; Chapin, RE; Gulati, DK; Li, LH; Wine, RN, 1997) |
| " Maternal body weights throughout the dosing period were comparable in all groups." | 1.30 | Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: an antiandrogenic mechanism? ( Cattley, RC; Foster, PM; Mylchreest, E, 1998) |
| " It was concluded that DBP administered during the second half of pregnancy produced adverse effects on the reproductive development in male fetuses." | 1.30 | Further evaluation of developmental toxicity of di-n-butyl phthalate following administration during late pregnancy in rats. ( Ema, M; Kawashima, K; Miyawaki, E, 1998) |
| " Postimplantation loss was 100% for each period of dosing at 1." | 1.29 | Characterization of the developmental toxicity of di-n-butyl phthalate in rats. ( Amano, H; Ema, M; Ogawa, Y, 1994) |
| "n-Butyl benzyl phthalate (BBP) and di-n-butyl phthalate (DBP) were evaluated and compared for their developmental toxic potential." | 1.29 | Comparative developmental toxicity of n-butyl benzyl phthalate and di-n-butyl phthalate in rats. ( Amano, H; Ema, M; Kurosaka, R; Ogawa, Y, 1995) |
| " Long-term dosing studies indicating reduced fertility in the rat suggested a maternal effect of the compound." | 1.27 | Dibutyl phthalate: maternal effects versus fetotoxicity. ( Cummings, AM; Gray, LE, 1987) |
| "The major malformations in treated groups were neural tube defects (exencephaly and myeloschisis), suggesting that the phthalic acid esters (PAEs) affect neural tube closure in developing embryos." | 1.26 | Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice. ( Nishimura, H; Shiota, K, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (2.07) | 18.7374 |
| 1990's | 11 (5.70) | 18.2507 |
| 2000's | 57 (29.53) | 29.6817 |
| 2010's | 83 (43.01) | 24.3611 |
| 2020's | 38 (19.69) | 2.80 |
| Authors | Studies |
|---|---|
| Alsubaie, AM | 1 |
| Arita, Y | 1 |
| Atwater, M | 1 |
| Mahfuz, A | 1 |
| Peltier, MR | 1 |
| Zhang, T | 4 |
| Zhou, X | 5 |
| Zhang, X | 3 |
| Ren, X | 1 |
| Wu, J | 4 |
| Wang, Z | 2 |
| Wang, S | 2 |
| Zhang, J | 4 |
| Zhou, K | 1 |
| Cheng, R | 1 |
| Yang, M | 1 |
| Shen, X | 3 |
| Luo, X | 1 |
| Xu, L | 1 |
| Wakui, S | 7 |
| Sato, D | 1 |
| Okayama, Y | 3 |
| Kansaku, N | 5 |
| Muto, T | 1 |
| Okpara, KE | 1 |
| Phoungthong, K | 1 |
| Agbozu, I | 1 |
| Edwin-Isotu, E | 1 |
| Techato, K | 1 |
| Xia, Y | 4 |
| Chen, J | 4 |
| Ma, T | 5 |
| Meng, X | 1 |
| Han, X | 5 |
| Li, D | 7 |
| Guo, X | 1 |
| Sheng, Y | 1 |
| Liu, B | 1 |
| Tang, P | 1 |
| Liu, R | 1 |
| Wu, L | 2 |
| Huang, D | 1 |
| Liu, S | 3 |
| Qiu, X | 1 |
| Xie, Z | 2 |
| Hua, S | 1 |
| Zhang, Y | 6 |
| Zhu, Y | 1 |
| Shi, F | 1 |
| Jiang, J | 2 |
| Shan, D | 1 |
| Li, L | 3 |
| Sun, Y | 1 |
| Wang, D | 1 |
| Li, Y | 3 |
| Yang, Z | 1 |
| Cui, K | 1 |
| Wu, S | 1 |
| Jin, L | 1 |
| Hong, B | 1 |
| Shang, X | 2 |
| Wang, Q | 2 |
| Gray, LE | 13 |
| Conley, JM | 1 |
| Lambright, CS | 2 |
| Furr, JR | 3 |
| Fang, H | 1 |
| Wang, H | 4 |
| Zeng, C | 1 |
| Fu, H | 1 |
| Zhao, B | 2 |
| Liu, A | 1 |
| Yan, J | 1 |
| Eisner, A | 1 |
| Gao, Y | 1 |
| Collier, F | 1 |
| Drummond, K | 1 |
| Thomson, S | 1 |
| Burgner, D | 1 |
| Vuillermin, P | 1 |
| Tang, ML | 1 |
| Mueller, J | 1 |
| Symeonides, C | 1 |
| Saffery, R | 1 |
| Ponsonby, AL | 1 |
| Abulimiti, G | 1 |
| Wang, Y | 8 |
| Zhang, Q | 3 |
| Cong, R | 2 |
| Ji, C | 2 |
| Luan, J | 2 |
| Yao, L | 2 |
| Yang, J | 1 |
| Song, N | 2 |
| Wang, X | 6 |
| He, C | 2 |
| Wu, N | 2 |
| Tian, Y | 2 |
| Wang, L | 2 |
| Liao, J | 2 |
| Fang, D | 2 |
| Liu, X | 3 |
| An, S | 2 |
| Chen, W | 2 |
| Xiong, S | 2 |
| Liu, Y | 2 |
| Xie, Y | 2 |
| Tian, K | 2 |
| Huang, J | 2 |
| Yuan, H | 2 |
| Chen, X | 6 |
| Zhang, L | 3 |
| Li, Q | 3 |
| Zhou, Y | 4 |
| Li, H | 3 |
| Jiang, Y | 1 |
| Liu, M | 1 |
| Yu, J | 1 |
| Feng, X | 1 |
| Xu, X | 2 |
| Sun, X | 1 |
| Yu, Y | 1 |
| Wang, B | 2 |
| Yang, F | 2 |
| Ding, J | 4 |
| Wang, J | 4 |
| Tao, L | 1 |
| Zhang, H | 3 |
| Xu, P | 1 |
| Liao, D | 1 |
| Hu, Z | 1 |
| Hou, X | 1 |
| Zeng, R | 1 |
| Mohanty, G | 1 |
| Tourzani, DA | 1 |
| Gervasi, MG | 1 |
| Houle, E | 1 |
| Oluwayiose, O | 1 |
| Suvorov, A | 1 |
| Pilsner, JR | 1 |
| Visconti, PE | 1 |
| Ham, D | 1 |
| Ha, M | 2 |
| Park, H | 2 |
| Hong, YC | 2 |
| Kim, Y | 3 |
| Ha, E | 1 |
| Bae, S | 1 |
| Silinski, MAR | 1 |
| Fernando, RA | 1 |
| Robinson, VG | 1 |
| Waidyanatha, S | 1 |
| Lee, SM | 1 |
| Jeon, S | 1 |
| Jeong, HJ | 1 |
| Kim, BN | 2 |
| Ji, J | 1 |
| Ma, L | 8 |
| Mo, J | 1 |
| Chen, Y | 1 |
| Xie, L | 1 |
| Li, X | 7 |
| Lin, Z | 1 |
| Ge, RS | 2 |
| Zhao, S | 5 |
| Pan, L | 2 |
| Chen, M | 3 |
| Zhu, YP | 9 |
| Han, BM | 5 |
| Xia, SJ | 9 |
| Jiang, JT | 16 |
| Guo, WH | 1 |
| Xie, ZW | 1 |
| Sun, WL | 11 |
| Ye, Q | 1 |
| Su, YM | 1 |
| Zhao, J | 1 |
| Jia, GZ | 1 |
| Evans, SF | 2 |
| Raymond, S | 1 |
| Sethuram, S | 1 |
| Barrett, ES | 2 |
| Bush, NR | 2 |
| Nguyen, R | 1 |
| Sathyanarayana, S | 2 |
| Swan, SH | 3 |
| Li, J | 2 |
| Qu, Z | 1 |
| Qian, H | 1 |
| van den Driesche, S | 7 |
| Shoker, S | 1 |
| Inglis, F | 1 |
| Palermo, C | 1 |
| Langsch, A | 1 |
| Otter, R | 1 |
| Chibbar, R | 1 |
| Moss, AC | 1 |
| Wenzel, AG | 2 |
| Reiner, JL | 1 |
| Kohno, S | 1 |
| Wolf, BJ | 1 |
| Brock, JW | 3 |
| Cruze, L | 2 |
| Newman, RB | 2 |
| Kucklick, JR | 2 |
| Czubacka, E | 1 |
| Czerczak, S | 1 |
| Kupczewska-Dobecka, MM | 1 |
| Morová, M | 1 |
| Senko, T | 1 |
| Olexová, L | 1 |
| Dzirbíková, Z | 1 |
| Kršková, L | 1 |
| Bloom, MS | 1 |
| Valachovic, EL | 1 |
| Begum, TF | 1 |
| Wineland, RJ | 1 |
| Unal, ER | 1 |
| Hunter, D | 1 |
| Heng, K | 2 |
| Mann, N | 1 |
| Anand-Ivell, R | 2 |
| Ivell, R | 4 |
| Song, L | 1 |
| Zhang, W | 11 |
| Jin, H | 1 |
| de Mello Santos, T | 1 |
| da Silveira, LTR | 1 |
| Rinaldi, JC | 1 |
| Scarano, WR | 5 |
| Domeniconi, RF | 3 |
| Zhou, C | 1 |
| Gao, L | 1 |
| Flaws, JA | 1 |
| Chen, L | 3 |
| Wang, XJ | 1 |
| Jiang, QH | 1 |
| Bei, XY | 2 |
| Guan, H | 1 |
| Dong, Y | 1 |
| Lian, Q | 1 |
| Hu, G | 1 |
| Lara, NLM | 1 |
| Macpherson, S | 3 |
| França, LR | 2 |
| Sharpe, RM | 15 |
| Wempe, MF | 6 |
| Sugiyama, M | 1 |
| Motohashi, M | 5 |
| Mutou, T | 6 |
| Takahashi, H | 6 |
| Kume, E | 1 |
| Ikegami, H | 1 |
| Saillenfait, AM | 5 |
| Sabaté, JP | 4 |
| Denis, F | 1 |
| Antoine, G | 1 |
| Robert, A | 1 |
| Roudot, AC | 1 |
| Ndiaye, D | 1 |
| Eljarrat, E | 1 |
| Ni, XS | 1 |
| Jing, DD | 1 |
| Yao, YT | 1 |
| Ding, W | 1 |
| Liu, ZH | 5 |
| Ding, GX | 1 |
| Gao, H | 1 |
| Wu, W | 1 |
| Xu, Y | 1 |
| Jin, Z | 1 |
| Bao, H | 1 |
| Zhu, P | 1 |
| Su, P | 1 |
| Sheng, J | 1 |
| Hao, J | 1 |
| Tao, F | 1 |
| Yin, X | 1 |
| Han, R | 1 |
| Li, EH | 7 |
| Wei, HB | 1 |
| Lhuangi, BG | 1 |
| Xu, ZH | 1 |
| Zhang, DH | 1 |
| Christante, CM | 2 |
| Pinto-Fochi, ME | 2 |
| Negrin, AC | 2 |
| Taboga, SR | 5 |
| Góes, RM | 2 |
| Liao, KW | 1 |
| Kuo, PL | 1 |
| Huang, HB | 1 |
| Chang, JW | 1 |
| Chiang, HC | 1 |
| Huang, PC | 1 |
| Shen, C | 1 |
| Wood, K | 4 |
| de Jesus, MM | 1 |
| da Silva, DGH | 1 |
| Zhao, Z | 1 |
| Liu, GC | 1 |
| Fu, W | 1 |
| Rashad, MM | 1 |
| Galal, MK | 1 |
| El-Behairy, AM | 1 |
| Gouda, EM | 1 |
| Moussa, SZ | 1 |
| Bornehag, CG | 2 |
| Lindh, C | 1 |
| Reichenberg, A | 1 |
| Wikström, S | 1 |
| Unenge Hallerback, M | 1 |
| Nguyen, RHN | 1 |
| Liu, L | 1 |
| Xiao, T | 1 |
| Shen, H | 6 |
| Venturelli, AC | 1 |
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| de Camargo, J | 1 |
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| Repouskou, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Phthalate Inhalation on Airway Immunology: A Controlled Human Exposure Study[NCT02688478] | 20 participants (Anticipated) | Interventional | 2017-02-02 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for dibutyl phthalate and Pregnancy
| Article | Year |
|---|---|
Mesalamine in the Initial Therapy of Ulcerative Colitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Dibutyl Phthalate; Drug Compounding; E | 2020 |
The overview of current evidence on the reproductive toxicity of dibutyl phthalate.
Topics: Animals; Dibutyl Phthalate; Embryonic Development; Endocrine Disruptors; Female; Fertility; Male; Ma | 2021 |
Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development.
Topics: Androgen Antagonists; Animals; Bridged Bicyclo Compounds; Complex Mixtures; Dibutyl Phthalate; Dieth | 2009 |
Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity.
Topics: Androgen Antagonists; Animals; Bridged Bicyclo Compounds; Cell Differentiation; Dibutyl Phthalate; D | 2010 |
Assessing exposure to phthalates - the human biomonitoring approach.
Topics: Biomarkers; Dibutyl Phthalate; Diethylhexyl Phthalate; Environmental Exposure; Environmental Monitor | 2011 |
Antiandrogenic effects of dibutyl phthalate and its metabolite, monobutyl phthalate, in rats.
Topics: Androgen Antagonists; Animals; Dibutyl Phthalate; Female; Phthalic Acids; Pregnancy; Rats; Rats, Wis | 2002 |
Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat: implications for human risk assessment.
Topics: Animals; Dibutyl Phthalate; Female; Genitalia, Male; Humans; Male; Pregnancy; Rats; Reproduction; Ri | 2000 |
186 other studies available for dibutyl phthalate and Pregnancy
| Article | Year |
|---|---|
Enhancement of placental inflammation by Dibutyl Phthalate.
Topics: Brain-Derived Neurotrophic Factor; Dibutyl Phthalate; Environmental Pollutants; Female; Gene Express | 2021 |
Gut microbiota may contribute to the postnatal male reproductive abnormalities induced by prenatal dibutyl phthalate exposure.
Topics: Dibutyl Phthalate; Endocrine Disruptors; Female; Gastrointestinal Microbiome; Humans; Male; Pregnanc | 2022 |
Maternal Perinatal Exposure to Dibutyl Phthalate Promotes Ovarian Dysfunction in Adult Female Offspring via Downregulation of TGF-β2 and TGF-β3.
Topics: Animals; Dibutyl Phthalate; Down-Regulation; Estradiol; Estrogen Receptor Antagonists; Female; Mater | 2022 |
Prenatal exposure to di(n-butyl) phthalate delays the spermatogenic cycle in rats: Investigation using a BrdU-injection method.
Topics: Animals; Bromodeoxyuridine; Dibutyl Phthalate; Female; Male; Phthalic Acids; Pregnancy; Prenatal Exp | 2022 |
Toxicology and carcinogenesis studies of di-n-butyl phthalate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.
Topics: Animals; Carcinogenesis; Dibutyl Phthalate; Female; Male; Mice; Mice, Inbred Strains; Neoplasms, Exp | 2021 |
Phthalate Esters in Tap Water, Southern Thailand: Daily Exposure and Cumulative Health Risk in Infants, Lactating Mothers, Pregnant and Nonpregnant Women.
Topics: China; Dibutyl Phthalate; Drinking Water; Esters; Female; Humans; Lactation; Mothers; Phthalic Acids | 2022 |
Maternal DBP exposure promotes synaptic formation in offspring by activating astrocytes via the AKT/NF-κB/IL-6/JAK2/STAT3 signaling pathway.
Topics: Animals; Astrocytes; Dibutyl Phthalate; Female; Humans; Interleukin-6; Janus Kinase 2; Maternal Expo | 2022 |
Exposure to phthalates in early pregnancy and the risk of fetal growth restriction: a nested case-control study in a Zhuang Chinese population.
Topics: Bayes Theorem; Case-Control Studies; China; Dibutyl Phthalate; Diethylhexyl Phthalate; Female; Fetal | 2022 |
Preconception exposure to dibutyl phthalate (DBP) impairs spermatogenesis by activating NF-κB/COX-2/RANKL signaling in Sertoli cells.
Topics: Cyclooxygenase 2; Dibutyl Phthalate; Female; Humans; Male; NF-kappa B; Pregnancy; RANK Ligand; Serto | 2022 |
Cumulative risk assessment of dietary exposure to phthalates in pregnant women in Beijing, China.
Topics: Beijing; China; Dibutyl Phthalate; Dietary Exposure; Diethylhexyl Phthalate; Environmental Exposure; | 2022 |
In Utero Exposure to a Mixture of the Perfluoroalkyl-Isopropyl Pesticide Pyrifluquinazon With Dibutyl Phthalate Cumulatively Disrupts Male Rat Reproductive Development via Different Mechanisms of Action.
Topics: Androgen Antagonists; Androgens; Animals; Dibutyl Phthalate; Female; Fluorocarbons; Genitalia, Male; | 2022 |
A preliminary cumulative risk assessment of Diethylhexyl phthalate and Dibutyl phthalate based on the inhibition of embryonic development via the PPARγ pathway.
Topics: Dibutyl Phthalate; Diethylhexyl Phthalate; Embryonic Development; Female; Humans; Phthalic Acids; Pl | 2022 |
Cord blood immune profile: Associations with higher prenatal plastic chemical levels.
Topics: Chemokine CXCL10; Child; Dibutyl Phthalate; Environmental Exposure; Environmental Pollutants; Female | 2022 |
Identification of endocrine-disrupting chemicals targeting the genes and pathways of genital anomalies in males.
Topics: Animals; Cryptorchidism; Dibutyl Phthalate; Endocrine Disruptors; Female; Genitalia; Humans; Hypospa | 2022 |
Maternal urine phthalate metabolite exposure and miscarriage risk: a nested case-control study of the Zunyi Birth Cohort.
Topics: Abortion, Spontaneous; Birth Cohort; Case-Control Studies; Dibutyl Phthalate; Environmental Exposure | 2023 |
DNA methylation-mediated inhibition of MGARP is involved in impaired progeny testosterone synthesis in mice exposed to DBP in utero.
Topics: Animals; Dibutyl Phthalate; DNA Methylation; Female; Male; Mice; Mice, Inbred C57BL; Pregnancy; Seme | 2023 |
Environmentally relevant perinatal exposure to DBP accelerated spermatogenesis by promoting the glycolipid metabolism of Sertoli cells in male offspring mice.
Topics: Animals; Dibutyl Phthalate; Female; Glucose; Glucose Transporter Type 3; Glycolipids; Male; Mice; Pr | 2023 |
Risk assessment and environmental determinants of urinary phthalate metabolites in pregnant women in Southwest China.
Topics: China; Creatinine; Dibutyl Phthalate; Environmental Exposure; Esters; Female; Humans; Kerosene; Phth | 2023 |
Effects of preconception exposure to phthalates on mouse sperm capacitation parameters.
Topics: Adult; Animals; Cyclic AMP-Dependent Protein Kinases; Dibutyl Phthalate; Female; Humans; Male; Mice; | 2023 |
Association of postnatal exposure to mixture of bisphenol A, Di-n-butyl phthalate and Di-(2-ethylhexyl) phthalate with Children's IQ at 5 Years of age: Mothers and Children's environmental health (MOCEH) study.
Topics: Child; Child, Preschool; Cohort Studies; Dibutyl Phthalate; Diethylhexyl Phthalate; Endocrine Disrup | 2024 |
Development and Validation of an Analytical Method for Quantitation of Monobutylphthalate, a Metabolite of Di-n-Butylphthalate, in Rat Plasma, Amniotic Fluid, Fetuses and Pups by UPLC-MS/MS.
Topics: Amniotic Fluid; Animals; Calibration; Chromatography, Liquid; Dibutyl Phthalate; Female; Lactation; | 2020 |
Dibutyl phthalate exposure during gestation and lactation in C57BL/6 mice: Maternal behavior and neurodevelopment in pups.
Topics: Animals; Dibutyl Phthalate; Female; Humans; Lactation; Maternal Behavior; Maternal Exposure; Mice; M | 2020 |
In utero exposure to DBP stimulates release of GnRH by increasing the secretion of PGE2 in the astrocytes of the hypothalamus in the offspring mice.
Topics: Animals; Astrocytes; Bodily Secretions; Dibutyl Phthalate; Dinoprostone; Endocrine Disruptors; Femal | 2020 |
In utero cadmium and dibutyl phthalate combination exposure worsens the defects of fetal testis in rats.
Topics: Animals; Cadmium; Dibutyl Phthalate; Female; Fetus; Leydig Cells; Male; Pregnancy; Rats; Rats, Sprag | 2020 |
In utero di-n-butyl phthalate exposure induced abnormal autophagy in renal tubular cells via hedgehog signaling in newborn rats.
Topics: Animals; Animals, Newborn; Autophagy; Cell Line; Dibutyl Phthalate; Female; Hedgehog Proteins; Kidne | 2020 |
Maternal exposure to Di-n-butyl phthalate (DBP) aggravate gestational diabetes mellitus via FoxM1 suppression by pSTAT1 signalling.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes, Gestational; Dibutyl Phthalate; | 2020 |
Activation of the RhoA/ROCK pathway contributes to renal fibrosis in offspring rats induced by maternal exposure to di-n-butyl phthalate.
Topics: Animals; Cell Line; Dibutyl Phthalate; Epithelial Cells; Epithelial-Mesenchymal Transition; Female; | 2020 |
Associations between prenatal phthalate exposure and sex-typed play behavior in preschool age boys and girls.
Topics: Child; Child Development; Child, Preschool; Dibutyl Phthalate; Environmental Exposure; Environmental | 2021 |
Intrauterine exposure to low-dose DBP in the mice induces obesity in offspring via suppression of UCP1 mediated ER stress.
Topics: Animals; Apoptosis; Body Composition; Dibutyl Phthalate; Endocrine Disruptors; Endoplasmic Reticulum | 2020 |
Systematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window.
Topics: Animals; Cryptorchidism; Dibutyl Phthalate; Dose-Response Relationship, Drug; Endocrine Disruptors; | 2020 |
Biomonitoring of emerging DINCH metabolites in pregnant women in charleston, SC: 2011-2014.
Topics: Adult; Biological Monitoring; Chromatography, Liquid; Cyclohexanecarboxylic Acids; Cyclohexanes; Dib | 2021 |
A mixture of diethylhexyl, diisononyl and dibutyl phthalate decreased anogenital distance, postnatal testosterone levels, and changed social behavior in Wistar rats.
Topics: Animals; Animals, Newborn; Dibutyl Phthalate; Diethylhexyl Phthalate; Female; Genitalia; Male; Mater | 2020 |
Association between gestational phthalate exposure and newborn head circumference; impacts by race and sex.
Topics: Dibutyl Phthalate; Environmental Exposure; Environmental Pollutants; Female; Fetal Development; Huma | 2021 |
Maternal Exposure to Dibutyl Phthalate (DBP) or Diethylstilbestrol (DES) Leads to Long-Term Changes in Hypothalamic Gene Expression and Sexual Behavior.
Topics: Animals; Aromatase; Dibutyl Phthalate; Diethylstilbestrol; Estrogens, Non-Steroidal; Female; Gonadot | 2021 |
Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats.
Topics: Animals; Dibutyl Phthalate; Disease Models, Animal; Environmental Pollutants; Erectile Dysfunction; | 2021 |
Environmentally relevant perinatal exposure to DBP disturbs testicular development and puberty onset in male mice.
Topics: Animals; Blood-Testis Barrier; Dibutyl Phthalate; Endocrine Disruptors; Female; Gonadal Steroid Horm | 2021 |
Alterations in prostate morphogenesis in male rat offspring after maternal exposure to Di-n-butyl-phthalate (DBP).
Topics: Androgen Antagonists; Animals; Bone Morphogenetic Protein 4; Dibutyl Phthalate; Environmental Pollut | 2017 |
Exposure to an Environmentally Relevant Phthalate Mixture Causes Transgenerational Effects on Female Reproduction in Mice.
Topics: Animals; Dibutyl Phthalate; Diethylhexyl Phthalate; Endocrine Disruptors; Environmental Exposure; En | 2017 |
Maternal exposure to di-n-butyl phthalate (DBP) induces renal fibrosis in adult rat offspring.
Topics: Animals; Apoptosis; Ascorbic Acid; Cell Proliferation; Dibutyl Phthalate; Disease Models, Animal; En | 2017 |
Prenatal exposure to di-n-butyl phthalate disrupts the development of adult Leydig cells in male rats during puberty.
Topics: Animals; Animals, Newborn; Dibutyl Phthalate; Dose-Response Relationship, Drug; Down-Regulation; Fem | 2017 |
Dibutyl phthalate induced testicular dysgenesis originates after seminiferous cord formation in rats.
Topics: Animals; Dibutyl Phthalate; Disease Models, Animal; Female; Fetus; Gonadal Dysgenesis; Humans; Leydi | 2017 |
In Utero Exposure to Di( n-butyl)phthalate Induces Morphological and Biochemical Changes in Rats Postpuberty.
Topics: Animals; Animals, Newborn; Dibutyl Phthalate; Female; Follicle Stimulating Hormone; Male; Maternal E | 2017 |
Evaluation of the effects of α-cypermethrin on fetal rat testicular steroidogenesis.
Topics: Animals; Body Weight; Dibutyl Phthalate; Female; Fetus; Gene Expression Regulation, Developmental; I | 2017 |
Potential involvement of Fgf10/Fgfr2 and androgen receptor (AR) in renal fibrosis in adult male rat offspring subjected to prenatal exposure to di-n-butyl phthalate (DBP).
Topics: Animals; Dibutyl Phthalate; Environmental Pollutants; Female; Fibroblast Growth Factor 10; Fibrosis; | 2018 |
Effects of Prenatal Phthalate Exposure on Thyroid Hormone Concentrations Beginning at The Embryonic Stage.
Topics: Adult; Analysis of Variance; Dibutyl Phthalate; Environmental Exposure; Female; Humans; Maternal Exp | 2017 |
Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat.
Topics: Animals; Dibutyl Phthalate; Endocrine Disruptors; Female; Male; MAP Kinase Kinase 1; MAP Kinase Kina | 2017 |
[Hypospadias induced by maternal exposure to di-n-butyl phthalate and its mechanisms in male rat offspring , , , , ,].
Topics: Animals; Body Weight; Bone Morphogenetic Protein 4; Dibutyl Phthalate; Female; Fibroblast Growth Fac | 2017 |
Effects of gestational exposure to di-n-butyl phthalate and mineral oil on testis development of the Mongolian gerbil.
Topics: Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Dibutyl Phthalate; Endocrine Disru | 2018 |
Increased risk of phthalates exposure for recurrent pregnancy loss in reproductive-aged women.
Topics: Adult; Dibutyl Phthalate; Diethylhexyl Phthalate; Environmental Exposure; Environmental Pollutants; | 2018 |
Maternal exposure to di-n-butyl phthalate (DBP) promotes epithelial-mesenchymal transition via regulation of autophagy in uroepithelial cell.
Topics: Animals; Autophagy; Cells, Cultured; Dibutyl Phthalate; Epithelial-Mesenchymal Transition; Female; H | 2018 |
Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserve.
Topics: Animals; Corn Oil; Dibutyl Phthalate; Endocrine Disruptors; Estradiol; Female; Gerbillinae; Lipid Me | 2018 |
Role of PERK-eIF2α signaling pathway in fetal male rats with hypospadias induced by di-n-butyl phthalate.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Dibutyl Phthalate; eIF-2 Kinase; Eukaryotic I | 2018 |
Maternal exposure to di-n-butyl phthalate induces alterations of c-Myc gene, some apoptotic and growth related genes in pups' testes.
Topics: Animals; Apoptosis; Dibutyl Phthalate; Female; Genes, myc; Male; Maternal Exposure; Pregnancy; Rats; | 2018 |
Association of Prenatal Phthalate Exposure With Language Development in Early Childhood.
Topics: Adolescent; Adult; Child, Preschool; Dibutyl Phthalate; Environmental Exposure; Female; Humans; Lang | 2018 |
Maternal exposure to di-n-butyl phthalate promotes Snail1-mediated epithelial-mesenchymal transition of renal tubular epithelial cells via upregulation of TGF-β1 during renal fibrosis in rat offspring.
Topics: Animals; Animals, Newborn; Cell Line; Dibutyl Phthalate; Down-Regulation; Epithelial Cells; Epitheli | 2019 |
Phthalate exposure and cumulative risk in a Chinese newborn population.
Topics: Adult; Asian People; Child; China; Cross-Sectional Studies; Dibutyl Phthalate; Environmental Exposur | 2019 |
Effects of in utero and lactational exposure to phthalates on reproductive development and glycemic homeostasis in rats.
Topics: Anal Canal; Animals; Blood Glucose; Dibutyl Phthalate; Diethylhexyl Phthalate; Female; Genitalia; Ho | 2019 |
Experimental cryptorchidism enhances testicular susceptibility to dibutyl phthalate or acrylamide in Sprague-Dawley rats.
Topics: Acrylamide; Animals; Cryptorchidism; Dibutyl Phthalate; Disease Models, Animal; Female; Male; Matern | 2019 |
Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes.
Topics: Animals; Aromatase; Dibutyl Phthalate; Diethylhexyl Phthalate; Environmental Pollutants; Estradiol; | 2019 |
Isolation and molecular characterization of spermatogonia from male Sprague-Dawley rats exposed
Topics: Acrylamide; Animals; Body Weight; Cell Differentiation; Cell Proliferation; Dibutyl Phthalate; Envir | 2019 |
Longitudinal Metabolic Impacts of Perinatal Exposure to Phthalates and Phthalate Mixtures in Mice.
Topics: Adipokines; Animals; Body Composition; Caenorhabditis elegans Proteins; Dibutyl Phthalate; Diethylhe | 2019 |
Dibutyl phthalate exposure disrupts the progression of meiotic prophase I by interfering with homologous recombination in fetal mouse oocytes.
Topics: Aneuploidy; Animals; Apoptosis; Dibutyl Phthalate; Endocrine Disruptors; Female; Homologous Recombin | 2019 |
Male Sprague-Dawley rats exposed to in utero di(n-butyl) phthalate: dose dependent and age-related morphological changes in Leydig cell smooth endoplasmic reticulum.
Topics: Age Factors; Animals; Body Weight; Dibutyl Phthalate; Dose-Response Relationship, Drug; Endoplasmic | 2013 |
Influence of oily vehicles on fetal testis and lipid profile of rats exposed to di-butyl phthalate.
Topics: Animals; Corn Oil; Dibutyl Phthalate; Endocrine Disruptors; Environmental Pollutants; Fatty Acids, M | 2014 |
Differential expression of peroxiredoxin 6, annexin A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1 in testis of rat fetuses after maternal exposure to di-n-butyl phthalate.
Topics: Animals; Annexin A5; Dibutyl Phthalate; Female; Fetus; Male; Maternal-Fetal Exchange; Peroxiredoxin | 2013 |
Neurotoxicity of dibutyl phthalate in brain development following perinatal exposure: a study in rats.
Topics: Age Factors; Animals; Apoptosis; Behavior, Animal; Caspase 3; Dibutyl Phthalate; Excitatory Postsyna | 2013 |
Short-term neonatal/prepubertal exposure of dibutyl phthalate (DBP) advanced pubertal timing and affected hypothalamic kisspeptin/GPR54 expression differently in female rats.
Topics: Anal Canal; Animals; Animals, Newborn; Body Weight; Dibutyl Phthalate; Estrous Cycle; Female; Gene E | 2013 |
Effects of in utero exposure to di(n-butyl) phthalate for estrogen receptors α, β, and androgen receptor of Leydig cell on rats.
Topics: Animals; Dibutyl Phthalate; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Leydig Cells; M | 2014 |
Dibutyl phthalate-induced neurotoxicity in the brain of immature and mature rat offspring.
Topics: Age Factors; Animals; Aromatase; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Bind | 2014 |
Effects of in utero di-butyl phthalate and butyl benzyl phthalate exposure on offspring development and male reproduction of rat.
Topics: 17-Hydroxysteroid Dehydrogenases; Animals; Body Weight; Dibutyl Phthalate; Female; Kidney; Liver; Ma | 2014 |
Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells.
Topics: Adult Stem Cells; Androgens; Animals; Callithrix; Cell Lineage; Dibutyl Phthalate; Female; Fetal Dev | 2014 |
Identification of gene expression changes in postnatal rat foreskin after in utero anti-androgen exposure.
Topics: Androgen Antagonists; Animals; Dibutyl Phthalate; Female; Flutamide; Foreskin; Gene Expression Regul | 2014 |
Expression of Wnt5a during development of anorectal malformations in a rat model of prenatal exposure to di(n-butyl) phthalate.
Topics: Animals; Anorectal Malformations; Anus, Imperforate; Blotting, Western; Dibutyl Phthalate; Female; G | 2014 |
Genetic research and structural dysplasia assessment of anorectal malformations in neonatal male rats induced by di(n-butyl) phthalate.
Topics: Animals; Animals, Newborn; Anorectal Malformations; Anus, Imperforate; Dibutyl Phthalate; Female; Ge | 2016 |
Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice.
Topics: Animals; Apoptosis; Cell Differentiation; Dibutyl Phthalate; Diethylhexyl Phthalate; Environmental E | 2014 |
Gestational and lactational exposition to Di-N-butyl-phthalate (DBP) increases inflammation and preneoplastic lesions in prostate of wistar rats after carcinogenic N-methyl-N-nitrosourea (MNU) plus testosterone protocol.
Topics: Animals; Blotting, Western; Dibutyl Phthalate; Estrogen Receptor alpha; Female; Inflammation; Lactat | 2016 |
The mechanism underlying dibutyl phthalate induced shortened anogenital distance and hypospadias in rats.
Topics: Anal Canal; Animals; Biomarkers; Cryptorchidism; Dibutyl Phthalate; Dose-Response Relationship, Drug | 2015 |
Di-n-Butyl Phthalate Induces Multinucleated Germ Cells in the Rat Fetal Testis Through a Nonproliferative Mechanism.
Topics: Animals; Dibutyl Phthalate; Female; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Spragu | 2015 |
Reduced Fgf10/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di-n-butyl phthalate (DBP): A study on the local and systemic toxicology of DBP.
Topics: Anal Canal; Animals; Animals, Newborn; Anorectal Malformations; Anus, Imperforate; Body Weight; Dibu | 2015 |
Male rats exposed in utero to di(n-butyl) phthalate: Age-related changes in Leydig cell smooth endoplasmic reticulum and testicular testosterone-biosynthesis enzymes/proteins.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Age Factors; Animals; Cell Shape; | 2016 |
[In utero exposure to di-n-butyl phthalate induces testicular cell apoptosis and vacuolization in the pubertal male rat offspring].
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Body Weight; Dibutyl Phthalate; Female; Immunohistoc | 2015 |
[Levels of phthalate internal exposure levels in pregnant women and influencing factors].
Topics: Chromatography, High Pressure Liquid; Dibutyl Phthalate; Female; Humans; Life Style; Maternal Exposu | 2015 |
Effects of maternal exposure to di-n-butyl phthalate during pregnancy and breastfeeding on ovarian development and function of F1 female rats.
Topics: Animals; Breast Feeding; Dibutyl Phthalate; Female; Hazardous Substances; Maternal Exposure; Ovary; | 2016 |
Prenatal exposure to di-n-butyl phthalate (DBP) differentially alters androgen cascade in undeformed versus hypospadiac male rat offspring.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Dibutyl Phthalate; Endocrine Disruptors; Female; Hyp | 2016 |
In utero-exposed di(n-butyl) phthalate induce dose dependent, age-related changes of morphology and testosterone-biosynthesis enzymes/associated proteins of Leydig cell mitochondria in rats.
Topics: Aging; Animals; Cholesterol Side-Chain Cleavage Enzyme; Dibutyl Phthalate; Dose-Response Relationshi | 2016 |
Maternal exposure to di-n-butyl phthalate (DBP) induces combined anorectal and urogenital malformations in male rat offspring.
Topics: Animals; Animals, Newborn; Anorectal Malformations; Dibutyl Phthalate; DNA-Binding Proteins; Female; | 2016 |
Endocrine disruptor phthalates in bottled water: daily exposure and health risk assessment in pregnant and lactating women.
Topics: Adult; Dibutyl Phthalate; Drinking Water; Endocrine Disruptors; Environmental Monitoring; Female; Ga | 2016 |
Di-n-butyl phthalate induced hypospadias relates to autophagy in genital tubercle via the PI3K/Akt/mTOR pathway.
Topics: Animals; Apoptosis; Autophagy; Carrier Proteins; Dibutyl Phthalate; Female; Fetus; Hypospadias; Male | 2017 |
Gestational di-n-butyl phthalate exposure induced developmental and teratogenic anomalies in rats: a multigenerational assessment.
Topics: Animals; Body Weight; Developmental Disabilities; Dibutyl Phthalate; Female; Litter Size; Male; Orga | 2017 |
Protection of male reproductive toxicity in rats exposed to di-n-butyl phthalate during embryonic development by testosterone.
Topics: Animals; Dibutyl Phthalate; Embryonic Development; Female; Infertility, Male; Male; Organ Size; Preg | 2017 |
In utero exposure of high-dose di- n-butyl phthalate resulted in opposite effects on testicular cell apoptosis in late embryonic and pubertal male rat offspring.
Topics: Animals; Apoptosis; Cells, Cultured; Cryptorchidism; Dibutyl Phthalate; Disorders of Sex Development | 2017 |
Gestational and lactational exposure to di-isobutyl phthalate via diet in maternal mice decreases testosterone levels in male offspring.
Topics: Animals; Dibutyl Phthalate; Endocrine Disruptors; Environmental Pollutants; Female; Fetal Blood; Lac | 2017 |
Analysis of di-n-butyl phthalate and other organic pollutants in Chongqing women undergoing parturition.
Topics: China; Dibutyl Phthalate; Environmental Pollutants; Female; Fetal Blood; Gas Chromatography-Mass Spe | 2008 |
Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the rat.
Topics: Age Factors; Androgens; Animals; Cell Count; Cell Division; Dibutyl Phthalate; Female; Immunohistoch | 2008 |
Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats.
Topics: Adrenal Glands; Animals; Body Weight; Dibutyl Phthalate; Estradiol; Female; Fetus; Gene Expression; | 2008 |
The orl rat with inherited cryptorchidism has increased susceptibility to the testicular effects of in utero dibutyl phthalate exposure.
Topics: Animals; Body Weight; Cryptorchidism; Dibutyl Phthalate; Disease Models, Animal; Dose-Response Relat | 2008 |
Diisobutyl phthalate impairs the androgen-dependent reproductive development of the male rat.
Topics: Administration, Oral; Animals; Dibutyl Phthalate; Dose-Response Relationship, Drug; Environmental Po | 2008 |
[Differential expression of ubiquitin C-terminal hydrolase L-1 in the rat testis following exposure to di-n-butyl phthalate in utero].
Topics: Animals; Animals, Newborn; Dibutyl Phthalate; Female; Immunohistochemistry; Male; Maternal Exposure; | 2008 |
Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats.
Topics: Amniotic Fluid; Animals; Area Under Curve; Biomarkers; Calibration; Chromatography, High Pressure Li | 2009 |
Dose-dependent effects on cell proliferation, seminiferous tubules, and male germ cells in the fetal rat testis following exposure to di(n-butyl) phthalate.
Topics: Animals; Cell Proliferation; Dibutyl Phthalate; Female; Fetus; Histocytochemistry; Male; Pregnancy; | 2009 |
Coadministration of active phthalates results in disruption of foetal testicular function in rats.
Topics: Androgen Antagonists; Animals; Dibutyl Phthalate; Diethylhexyl Phthalate; Female; Fertility; Fetus; | 2009 |
Adult rats exposed to low-doses of di-n-butyl phthalate during gestation exhibit decreased grooming behavior.
Topics: Animals; Behavior, Animal; Body Weight; Dibutyl Phthalate; Endocrine Disruptors; Female; Grooming; M | 2009 |
Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP).
Topics: Animals; Animals, Newborn; Bone Morphogenetic Proteins; Dibutyl Phthalate; Female; Fetal Development | 2009 |
Neurobehavioral toxicity study of dibutyl phthalate on rats following in utero and lactational exposure.
Topics: Animals; Behavior, Animal; Dibutyl Phthalate; Dose-Response Relationship, Drug; Female; Lactation; M | 2009 |
Long-term effects of developmental exposure to di-n-butyl-phthalate (DBP) on rat prostate: proliferative and inflammatory disorders and a possible role of androgens.
Topics: Animals; Cell Proliferation; Dibutyl Phthalate; Epithelial Cells; Female; Gene Expression Regulation | 2009 |
Reproductive toxicity and pharmacokinetics of di-n-butyl phthalate (DBP) following dietary exposure of pregnant rats.
Topics: Administration, Oral; Amniotic Fluid; Androgen Antagonists; Animals; Biotransformation; Body Weight; | 2009 |
Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development.
Topics: Animals; Dexamethasone; Dibutyl Phthalate; Female; Gene Expression; Glucocorticoids; Male; Maternal | 2009 |
Reproductive development and function of female rats exposed to di-eta-butyl-phthalate (DBP) in utero and during lactation.
Topics: Animals; Birth Weight; Dibutyl Phthalate; Female; Fertility; Fetal Weight; Lactation; Male; Ovary; P | 2010 |
Prenatal phthalate exposure and reduced masculine play in boys.
Topics: Child, Preschool; Dibutyl Phthalate; Diethylhexyl Phthalate; Environmental Exposure; Female; Gender | 2010 |
Androgen action in the masculinization programming window and development of male reproductive organs.
Topics: Androgen Antagonists; Androgens; Animals; Animals, Newborn; Dibutyl Phthalate; Female; Flutamide; Ge | 2010 |
Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat.
Topics: Animals; Dibutyl Phthalate; Female; Fetus; Flutamide; Immunohistochemistry; Male; Organ Size; Pregna | 2010 |
In utero exposure to an AR antagonist plus an inhibitor of fetal testosterone synthesis induces cumulative effects on F1 male rats.
Topics: Administration, Oral; Androgen Antagonists; Animals; Animals, Newborn; Bridged Bicyclo Compounds; Di | 2010 |
Functional and morphological reproductive aspects in male rats exposed to di-n-butyl phthalate (DBP) in utero and during lactation.
Topics: Animals; Animals, Suckling; Dibutyl Phthalate; Female; Fetal Development; Infertility, Male; Male; M | 2010 |
Pathway modeling of microarray data: a case study of pathway activity changes in the testis following in utero exposure to dibutyl phthalate (DBP).
Topics: Animals; Databases, Genetic; Dibutyl Phthalate; Environmental Pollutants; Female; Gene Expression Pr | 2013 |
Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anal Canal; Animals; Body Weight; Cryptorchidism; Dibutyl Pht | 2010 |
[Influence of dibutyl phthalate on development of hippocampus nervous cells of rat's offspring].
Topics: Animals; Dibutyl Phthalate; Female; Hippocampus; Male; Mitochondrial Proton-Translocating ATPases; N | 2010 |
[Proteomic analysis of the testis and differential expression of Annexin A3 in hypospadiac rats].
Topics: Animals; Animals, Newborn; Annexin A3; Dibutyl Phthalate; Epispadias; Female; Hypospadias; Male; Mat | 2010 |
Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways.
Topics: Animals; Blotting, Western; Dibutyl Phthalate; Dose-Response Relationship, Drug; Endocrine Disruptor | 2011 |
Effects of di(n-butyl) phthalate exposure on foetal rat germ-cell number and differentiation: identification of age-specific windows of vulnerability.
Topics: Animals; Cell Count; Cell Differentiation; Cell Proliferation; Dibutyl Phthalate; Female; Germ Cells | 2011 |
Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate.
Topics: Animals; Cytochrome P-450 CYP1A1; Dibutyl Phthalate; Diethylhexyl Phthalate; Dose-Response Relations | 2011 |
Differential expression of the Wnt/β-catenin pathway in the genital tubercle (GT) of fetal male rat following maternal exposure to di-n-butyl phthalate (DBP).
Topics: Animals; beta Catenin; Blotting, Western; Dibutyl Phthalate; Female; Genitalia, Male; Immunohistoche | 2011 |
Prenatal exposure to phthalates and infant development at 6 months: prospective Mothers and Children's Environmental Health (MOCEH) study.
Topics: Adult; Child Development; Dibutyl Phthalate; Diethylhexyl Phthalate; Female; Humans; Infant; Male; N | 2011 |
Metabolic signature of pregnant women with neural tube defects in offspring.
Topics: Adult; Animals; China; Dibutyl Phthalate; Female; Folic Acid; Gene Expression Regulation; Gestationa | 2011 |
Prenatal exposure to di-n-butyl phthalate induces anorectal malformations in male rat offspring.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anal Canal; Animals; Animals, Newborn; Body We | 2011 |
Developmental toxicity in mice following paternal exposure to Di-N-butyl-phthalate (DBP).
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Female; Male; Mice; Paternal Exposure; Plas | 2011 |
The role of androgen-induced growth factor (FGF8) on genital tubercle development in a hypospadiac male rat model of prenatal exposure to di-n-butyl phthalate.
Topics: Animals; Dibutyl Phthalate; Disease Models, Animal; Environmental Pollutants; Female; Fibroblast Gro | 2012 |
Prenatal di-n-butyl phthalate exposure alters reproductive functions at adulthood in male rats.
Topics: Animals; Dibutyl Phthalate; Female; Infertility, Male; Male; Pregnancy; Prenatal Exposure Delayed Ef | 2014 |
Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents.
Topics: Animals; Binding Sites; Cell Nucleus; COUP Transcription Factor II; Dibutyl Phthalate; DNA-Binding P | 2012 |
A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development.
Topics: Animals; Animals, Newborn; Dibutyl Phthalate; Diet; Dose-Response Relationship, Drug; Female; Lactat | 2013 |
Atypical Leydig cell hyperplasia in adult rats with low T and high LH induced by prenatal Di(n-butyl) phthalate exposure.
Topics: Animals; Dibutyl Phthalate; Female; Histocytochemistry; Hyperplasia; Leydig Cells; Luteinizing Hormo | 2013 |
Ovarian development in Wistar rat treated prenatally with single dose diisobutyl phthalate.
Topics: Animals; Dibutyl Phthalate; Female; Fetus; Injections, Intraperitoneal; Ovary; Plasticizers; Pregnan | 2012 |
Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring.
Topics: Animals; Dibutyl Phthalate; Diethylstilbestrol; Endocrine Disruptors; Female; Gene Expression Regula | 2013 |
Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Female; Genitalia, Male; Male; Maternal Exp | 2003 |
Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate.
Topics: Administration, Oral; Animals; Dibutyl Phthalate; DNA Primers; Environmental Pollutants; Female; Fet | 2003 |
Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate.
Topics: Age Factors; Animals; Body Weight; Dibutyl Phthalate; Disease Models, Animal; Female; Humans; Hyperp | 2003 |
Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholesterol; Dibutyl Phthalate; DNA-Binding Pr | 2004 |
Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis.
Topics: Abnormalities, Drug-Induced; Androgen Receptor Antagonists; Animals; Dibutyl Phthalate; Diethylhexyl | 2004 |
[Effects of prenatal exposure to phthalate ester on both testicular descent and urogenital development in rats].
Topics: Animals; Cryptorchidism; Dibutyl Phthalate; Female; Hypospadias; Male; Pregnancy; Prenatal Exposure | 2003 |
[Reproductive and developmental toxicity of F1 male rats treated with DBP in utero and during lactation].
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Environmental Exposure; Female; Lactation; | 2004 |
Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Azo Compounds; Blotting, Western; Coloring Agents; Dibutyl | 2004 |
Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dibutyl Phthalate; Epididymis; Female; Lactation; | 2004 |
Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation.
Topics: Animals; Body Weight; Dibutyl Phthalate; Diet; Endocrine Glands; Estrous Cycle; Female; Genitalia; G | 2004 |
Pharmacokinetics of dibutylphthalate in pregnant rats.
Topics: Algorithms; Amniotic Fluid; Animals; Biotransformation; Calibration; Chromatography, High Pressure L | 2004 |
Effect of oral intake of dibutyl phthalate on reproductive parameters of Long Evans rats and pre-pubertal development of their offspring.
Topics: Administration, Oral; Animals; Dibutyl Phthalate; Female; Fetus; Male; Pregnancy; Rats; Rats, Long-E | 2004 |
Abnormal Leydig Cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis.
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Animals; Cell Aggregation; Dibutyl Phthalate; Fem | 2005 |
Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses.
Topics: Animals; Cell Line, Tumor; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Dibutyl | 2005 |
Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Female; Genitalia, Male; Male; Maternal Exp | 2005 |
Differential steroidogenic gene expression in the fetal adrenal gland versus the testis and rapid and dynamic response of the fetal testis to di(n-butyl) phthalate.
Topics: Adrenal Glands; Animals; Cholesterol Side-Chain Cleavage Enzyme; Corticosterone; Dibutyl Phthalate; | 2005 |
Pharmacokinetics of monobutylphthalate, the active metabolite of di-n-butylphthalate, in pregnant rats.
Topics: Animals; Chromatography, Liquid; Dibutyl Phthalate; Female; Fetus; Glucuronides; Male; Mass Spectrom | 2005 |
Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate.
Topics: Animals; Cryptorchidism; Dibutyl Phthalate; DNA Primers; Female; Gene Expression Regulation, Develop | 2005 |
Urinary and amniotic fluid levels of phthalate monoesters in rats after the oral administration of di(2-ethylhexyl) phthalate and di-n-butyl phthalate.
Topics: Administration, Oral; Amniotic Fluid; Animals; Creatinine; Dibutyl Phthalate; Diethylhexyl Phthalate | 2006 |
Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis.
Topics: Androgen Antagonists; Animals; Body Weight; Dibutyl Phthalate; Female; Fetal Development; Fetus; Imm | 2006 |
Cellular origins of testicular dysgenesis in rats exposed in utero to di(n-butyl) phthalate.
Topics: Androgen Antagonists; Animals; Dibutyl Phthalate; Disease Models, Animal; Female; Humans; Leydig Cel | 2006 |
Developmental toxic effects of diisobutyl phthalate, the methyl-branched analogue of di-n-butyl phthalate, administered by gavage to rats.
Topics: Administration, Oral; Animals; Congenital Abnormalities; Dibutyl Phthalate; Dose-Response Relationsh | 2006 |
Chronic di-n-butyl phthalate exposure in rats reduces fertility and alters ovarian function during pregnancy in female Long Evans hooded rats.
Topics: Animals; Dibutyl Phthalate; Dose-Response Relationship, Drug; Female; Fertility; Ovary; Pregnancy; R | 2006 |
Role of androgens in fetal testis development and dysgenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androgen Antagonists; Animals; Body Weight; Carcinogens; Dibutyl P | 2007 |
Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP).
Topics: Animals; Animals, Newborn; Birth Weight; Dibutyl Phthalate; Disease Models, Animal; Dose-Response Re | 2007 |
Fetal mouse phthalate exposure shows that Gonocyte multinucleation is not associated with decreased testicular testosterone.
Topics: Animals; Carcinogenicity Tests; Cell Nucleus; Depression, Chemical; Dibutyl Phthalate; Female; Gene | 2007 |
Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes.
Topics: Animals; Animals, Newborn; Cholesterol Side-Chain Cleavage Enzyme; Dibutyl Phthalate; Diethylhexyl P | 2007 |
Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human.
Topics: Animals; Animals, Newborn; Callithrix; Cell Aggregation; Dibutyl Phthalate; Female; Humans; Leydig C | 2007 |
Differential expression of peroxiredoxin 6 in fetal rat testis following in utero exposure to di(n-butyl) phthalate.
Topics: Animals; Blotting, Western; Dibutyl Phthalate; Female; Gestational Age; Immunohistochemistry; Male; | 2007 |
In utero exposure to di(n-butyl) phthalate and testicular dysgenesis: comparison of fetal and adult end points and their dose sensitivity.
Topics: Animals; Cell Aggregation; Dibutyl Phthalate; Disease Models, Animal; Dose-Response Relationship, Dr | 2007 |
Tissue exposures to free and glucuronidated monobutylyphthalate in the pregnant and fetal rat following exposure to di-n-butylphthalate: evaluation with a PBPK model.
Topics: Administration, Oral; Animals; Area Under Curve; Dibutyl Phthalate; Female; Fetus; Glucuronides; Mal | 2008 |
A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner.
Topics: Animals; Body Weight; Dibutyl Phthalate; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; F | 2008 |
Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Dibutyl Phthalate; Diethylhexyl P | 1982 |
Embryotoxic effects of di-2-ethylhexyl phthalate (DEHP) and di-n-buty phthalate (DBP) in mice.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Diethylhexyl Phthalate; Female; Fetal Death | 1980 |
Comparative developmental toxicity of n-butyl benzyl phthalate and di-n-butyl phthalate in rats.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Embryo Loss; Embryonic and Fetal Developmen | 1995 |
Characterization of the developmental toxicity of di-n-butyl phthalate in rats.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Cleft Palate; Dibutyl Phthalate; Dose-Response | 1994 |
Teratogenic evaluation of di-n-butyl phthalate in rats.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Female; Fetus; Pregnancy; Rats; Rats, Wista | 1993 |
Embryolethality following maternal exposure to dibutyl phthalate during early pregnancy in rats.
Topics: Animals; Dibutyl Phthalate; Embryo, Mammalian; Female; Male; Pregnancy; Progesterone; Rats; Rats, Wi | 1997 |
Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dibutyl Phthalate; Female; Fertility; Male; Penis | 1997 |
Reproductive toxicology. Di-n-butylphthalate, rats.
Topics: Animals; Birth Weight; Body Weight; Dibutyl Phthalate; Dose-Response Relationship, Drug; Female; Fer | 1997 |
Reproductive toxicology. Di-n-butylphthalate, mice.
Topics: Animals; Body Weight; Dibutyl Phthalate; Dose-Response Relationship, Drug; Female; Fertility; Litter | 1997 |
Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: an antiandrogenic mechanism?
Topics: Androgen Antagonists; Animals; Dibutyl Phthalate; Dose-Response Relationship, Drug; Female; Genitali | 1998 |
Further evaluation of developmental toxicity of di-n-butyl phthalate following administration during late pregnancy in rats.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Body Weight; Dibutyl Phthalate; Diet; Eating | 1998 |
Assessment of the developmental toxicity, metabolism, and placental transfer of Di-n-butyl phthalate administered to pregnant rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Amniotic Fluid; Animals; Area Under Curve; Cleft | 1998 |
Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide.
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Cryptorchid | 1999 |
Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy.
Topics: Animals; Body Weight; Cryptorchidism; Dibutyl Phthalate; Embryonic and Fetal Development; Female; Ma | 2000 |
Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation.
Topics: Androgens; Animals; Dibutyl Phthalate; Dose-Response Relationship, Drug; Eating; Female; Fetal Death | 2000 |
Cellular and molecular mechanisms of action of linuron: an antiandrogenic herbicide that produces reproductive malformations in male rats.
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Animals; COS Cells; Dibutyl Phthalate; Dihydrotes | 2000 |
Baby ills from beauty aids?
Topics: Abnormalities, Drug-Induced; Animals; Consumer Product Safety; Cosmetics; Dibutyl Phthalate; Environ | 2001 |
Effects of mono-n-butyl phthalate on the development of rat embryos: in vivo and in vitro observations.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Dose-Response Relationship, Drug; Embryo, M | 2001 |
Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate.
Topics: Androgen Antagonists; Animals; Clusterin; Dibutyl Phthalate; Female; Fetus; Flutamide; Gene Expressi | 2001 |
Oxidative DNA damage in male Wistar rats exposed to di-n-butyl phthalate.
Topics: Animals; Carcinogens, Environmental; Deoxyguanosine; Dibutyl Phthalate; DNA Damage; Environmental Ex | 2002 |
Dibutyl phthalate: maternal effects versus fetotoxicity.
Topics: Animals; Dibutyl Phthalate; Embryo Implantation; Estrus; Female; Fetal Death; Fetus; Organ Size; Ova | 1987 |
[Autoallergenic action of dibutyl and dioctyl phthalates].
Topics: Animals; Antigens; Autoimmune Diseases; Dibutyl Phthalate; Diethylhexyl Phthalate; Embryo, Mammalian | 1986 |