dibutyl phthalate has been researched along with Delayed Effects, Prenatal Exposure in 74 studies
Dibutyl Phthalate: A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.
dibutyl phthalate : A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to investigate the mechanism of dibutyl phthalate (DBP) induced hypospadias and shortened anogenital distance (AGD)." | 7.81 | The mechanism underlying dibutyl phthalate induced shortened anogenital distance and hypospadias in rats. ( Chen, X; Feng, J; Li, N; Yuan, J; Zhang, W; Zhou, X, 2015) |
| "The purpose of this study was to investigate the mechanism of dibutyl phthalate (DBP) induced hypospadias and shortened anogenital distance (AGD)." | 3.81 | The mechanism underlying dibutyl phthalate induced shortened anogenital distance and hypospadias in rats. ( Chen, X; Feng, J; Li, N; Yuan, J; Zhang, W; Zhou, X, 2015) |
| "Dibutyl phthalate (DBP) was used at a high dose level (750 mg/kg bw/day) as an established positive control substance for anti-androgenic effects on the developing male reproductive tract." | 1.56 | Systematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window. ( Inglis, F; Langsch, A; Otter, R; Palermo, C; Shoker, S; van den Driesche, S, 2020) |
| "The prevalence of language delay was 10." | 1.48 | Association of Prenatal Phthalate Exposure With Language Development in Early Childhood. ( Barrett, ES; Bornehag, CG; Bush, NR; Evans, SF; Lindh, C; Nguyen, RHN; Reichenberg, A; Sathyanarayana, S; Swan, SH; Unenge Hallerback, M; Wikström, S, 2018) |
| " Pregnant CD-1 dams were orally dosed with vehicle (tocopherol-stripped corn oil) or a phthalate mixture (20 and 200 µg/kg/d, 200 and 500 mg/kg/d) daily from gestational day 10 to birth." | 1.46 | Exposure to an Environmentally Relevant Phthalate Mixture Causes Transgenerational Effects on Female Reproduction in Mice. ( Flaws, JA; Gao, L; Zhou, C, 2017) |
| " Therefore, long-term exposure to phthalate esters affected development and function of the primate testis in a time and dosage dependent manner." | 1.40 | Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice. ( Alpaugh, W; Avelar, GF; Bondareva, A; Conley, A; Coyle, KM; Dobrinski, I; França, LR; Meyers, S; Modelski, M; Rodriguez-Sosa, JR; Tang, L; Wynne-Edwards, K, 2014) |
| "While the frequency of undescended testes after 200 mg/kg DBP exposure in the orl strain appeared increased, these data were not statistically significant." | 1.35 | The orl rat with inherited cryptorchidism has increased susceptibility to the testicular effects of in utero dibutyl phthalate exposure. ( Barthold, JS; Campion, L; Herrmann, R; Johnson, KJ; McCahan, SM; Si, X, 2008) |
| "Diisobutyl phthalate (DiBP) has similar structural and application properties as DBP, and is being used as a substitute for DBP." | 1.33 | Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis. ( Axelstad, M; Borch, J; Dalgaard, M; Vinggaard, AM, 2006) |
| " In another experiment, pregnant dams were treated with DBP until gd 19, with the start of DBP treatment moved 1 d later into gestation for each treatment group, with the final group dosed only on gd 19." | 1.32 | Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism. ( Gaido, KW; Ross, SM; Thompson, CJ, 2004) |
| " The NOAEL (no observable adverse effect level) for developmental toxicity of DBP was established based on pup body weight and male reproductive lesions at 50 mg/kg BW/day." | 1.32 | Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL. ( Chen, B; Jiang, X; Zhang, Y, 2004) |
| "The objective of this study was to determine the susceptible days for the adverse effects of di-n-butyl phthalate (DBP) on development of reproductive system in male offspring following maternal administration on successive 3-day period during late pregnancy." | 1.31 | Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy. ( Ema, M; Kawashima, K; Miyawaki, E, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 20 (27.03) | 29.6817 |
| 2010's | 42 (56.76) | 24.3611 |
| 2020's | 12 (16.22) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 3 |
| Zhou, K | 1 |
| Cheng, R | 1 |
| Yang, M | 1 |
| Shen, X | 1 |
| Luo, X | 1 |
| Xu, L | 1 |
| Wakui, S | 6 |
| Sato, D | 1 |
| Okayama, Y | 2 |
| Kansaku, N | 4 |
| Muto, T | 1 |
| Eisner, A | 1 |
| Gao, Y | 1 |
| Collier, F | 1 |
| Drummond, K | 1 |
| Thomson, S | 1 |
| Burgner, D | 1 |
| Vuillermin, P | 1 |
| Tang, ML | 1 |
| Mueller, J | 1 |
| Symeonides, C | 1 |
| Saffery, R | 1 |
| Ponsonby, AL | 1 |
| Lee, SM | 1 |
| Jeon, S | 1 |
| Jeong, HJ | 1 |
| Kim, BN | 2 |
| Kim, Y | 2 |
| Zhao, S | 3 |
| Pan, L | 1 |
| Chen, M | 1 |
| Zhu, YP | 7 |
| Han, BM | 3 |
| Xia, SJ | 7 |
| Jiang, JT | 10 |
| Evans, SF | 2 |
| Raymond, S | 1 |
| Sethuram, S | 1 |
| Barrett, ES | 2 |
| Bush, NR | 2 |
| Nguyen, R | 1 |
| Sathyanarayana, S | 2 |
| Swan, SH | 3 |
| Li, H | 2 |
| Li, J | 1 |
| Qu, Z | 1 |
| Qian, H | 1 |
| Wang, H | 1 |
| Xu, X | 1 |
| Liu, S | 1 |
| van den Driesche, S | 4 |
| Shoker, S | 1 |
| Inglis, F | 1 |
| Palermo, C | 1 |
| Langsch, A | 1 |
| Otter, R | 1 |
| Morová, M | 1 |
| Senko, T | 1 |
| Olexová, L | 1 |
| Dzirbíková, Z | 1 |
| Kršková, L | 1 |
| Hunter, D | 1 |
| Heng, K | 2 |
| Mann, N | 1 |
| Anand-Ivell, R | 2 |
| Ivell, R | 3 |
| Zhou, X | 2 |
| Zhang, T | 1 |
| Song, L | 1 |
| Wang, Y | 1 |
| Zhang, Q | 1 |
| Cong, R | 1 |
| Ji, C | 1 |
| Luan, J | 1 |
| Yao, L | 1 |
| Zhang, W | 4 |
| Song, N | 1 |
| Wang, S | 1 |
| Ma, T | 1 |
| Zhou, Y | 1 |
| Xia, Y | 1 |
| Jin, H | 1 |
| Wang, B | 1 |
| Wu, J | 1 |
| Ding, J | 1 |
| Wang, J | 1 |
| Yang, F | 1 |
| Han, X | 1 |
| Li, D | 3 |
| de Mello Santos, T | 1 |
| da Silveira, LTR | 1 |
| Rinaldi, JC | 1 |
| Scarano, WR | 3 |
| Domeniconi, RF | 1 |
| Zhou, C | 1 |
| Gao, L | 1 |
| Flaws, JA | 1 |
| Chen, L | 2 |
| Wang, XJ | 1 |
| Jiang, QH | 1 |
| Bei, XY | 2 |
| Sun, WL | 7 |
| Chen, X | 2 |
| Li, L | 1 |
| Guan, H | 1 |
| Dong, Y | 1 |
| Li, X | 3 |
| Wang, Q | 1 |
| Lian, Q | 1 |
| Hu, G | 1 |
| Ge, RS | 1 |
| Lara, NLM | 1 |
| Macpherson, S | 2 |
| França, LR | 2 |
| Sharpe, RM | 10 |
| Wempe, MF | 5 |
| Sugiyama, M | 1 |
| Motohashi, M | 4 |
| Mutou, T | 5 |
| Takahashi, H | 5 |
| Kume, E | 1 |
| Ikegami, H | 1 |
| Ni, XS | 1 |
| Jing, DD | 1 |
| Yao, YT | 1 |
| Ding, W | 1 |
| Liu, ZH | 4 |
| Ding, GX | 1 |
| Christante, CM | 2 |
| Pinto-Fochi, ME | 2 |
| Negrin, AC | 2 |
| Taboga, SR | 3 |
| Góes, RM | 2 |
| Shen, C | 1 |
| Wood, K | 3 |
| de Jesus, MM | 1 |
| da Silva, DGH | 1 |
| Bornehag, CG | 2 |
| Lindh, C | 1 |
| Reichenberg, A | 1 |
| Wikström, S | 1 |
| Unenge Hallerback, M | 1 |
| Nguyen, RHN | 1 |
| Venturelli, AC | 1 |
| Meyer, KB | 1 |
| Fischer, SV | 1 |
| Kita, DH | 1 |
| Philipsen, RA | 1 |
| Morais, RN | 1 |
| Martino Andrade, AJ | 1 |
| Repouskou, A | 1 |
| Panagiotidou, E | 1 |
| Panagopoulou, L | 1 |
| Bisting, PL | 1 |
| Tuck, AR | 1 |
| Sjödin, MOD | 1 |
| Lindberg, J | 1 |
| Bozas, E | 1 |
| Rüegg, J | 1 |
| Gennings, C | 1 |
| Damdimopoulou, P | 1 |
| Stamatakis, A | 1 |
| Kitraki, E | 1 |
| Souza, NP | 1 |
| Arnold, LL | 1 |
| Pennington, KL | 1 |
| Nascimento E Pontes, MG | 1 |
| Miot, HA | 1 |
| de Camargo, JLV | 1 |
| Cohen, SM | 1 |
| Neier, K | 1 |
| Cheatham, D | 1 |
| Bedrosian, LD | 1 |
| Gregg, BE | 1 |
| Song, PXK | 1 |
| Dolinoy, DC | 1 |
| Shirai, M | 3 |
| Oyama, N | 2 |
| Asari, M | 3 |
| Hano, H | 2 |
| Endou, H | 3 |
| Li, XJ | 1 |
| Jiang, L | 2 |
| Chen, HS | 1 |
| Inomata, T | 3 |
| Ikegami, M | 2 |
| Cheng, L | 1 |
| Chen, H | 1 |
| Pike, JW | 1 |
| McDowell, E | 1 |
| McCahan, SM | 2 |
| Johnson, KJ | 2 |
| Li, EH | 3 |
| Xu, DL | 3 |
| Hong, Y | 3 |
| Zhao, W | 3 |
| Rodriguez-Sosa, JR | 1 |
| Bondareva, A | 1 |
| Tang, L | 1 |
| Avelar, GF | 1 |
| Coyle, KM | 1 |
| Modelski, M | 1 |
| Alpaugh, W | 1 |
| Conley, A | 1 |
| Wynne-Edwards, K | 1 |
| Meyers, S | 1 |
| Dobrinski, I | 1 |
| Li, N | 1 |
| Yuan, J | 1 |
| Feng, J | 1 |
| Spade, DJ | 1 |
| Hall, SJ | 1 |
| Wilson, S | 1 |
| Boekelheide, K | 1 |
| Shen, H | 2 |
| Liao, K | 3 |
| Wu, HF | 2 |
| Lu, HC | 2 |
| Li, Z | 2 |
| Zhong, C | 1 |
| Ruan, Y | 1 |
| Giribabu, N | 2 |
| Reddy, PS | 1 |
| Li, Y | 1 |
| Scott, HM | 5 |
| Hutchison, GR | 4 |
| Jobling, MS | 3 |
| McKinnell, C | 4 |
| Drake, AJ | 2 |
| Si, X | 1 |
| Campion, L | 1 |
| Herrmann, R | 1 |
| Barthold, JS | 1 |
| Saillenfait, AM | 1 |
| Sabaté, JP | 1 |
| Gallissot, F | 1 |
| Zhu, YJ | 1 |
| Ma, L | 2 |
| Liu, Q | 2 |
| Liu, GH | 1 |
| Toledo, FC | 1 |
| Guerra, MT | 2 |
| de Campos, SG | 1 |
| Júnior, LA | 1 |
| Felisbino, SL | 1 |
| Anselmo-Franci, JA | 1 |
| Kempinas, Wde G | 2 |
| de Toledo, FC | 1 |
| Franci, JA | 1 |
| Liu, F | 1 |
| Hines, M | 1 |
| Kruse, RL | 1 |
| Wang, C | 1 |
| Redmon, JB | 1 |
| Sparks, A | 1 |
| Weiss, B | 1 |
| Macleod, DJ | 1 |
| Welsh, M | 2 |
| Fisken, M | 1 |
| Auharek, SA | 1 |
| de Franca, LR | 1 |
| Kim, TS | 1 |
| Jung, KK | 1 |
| Kim, SS | 1 |
| Kang, IH | 1 |
| Baek, JH | 1 |
| Nam, HS | 1 |
| Hong, SK | 1 |
| Lee, BM | 1 |
| Hong, JT | 1 |
| Oh, KW | 1 |
| Kim, HS | 1 |
| Han, SY | 1 |
| Kang, TS | 1 |
| Ha, EH | 1 |
| Kim, EJ | 1 |
| Park, H | 1 |
| Ha, M | 1 |
| Kim, JH | 1 |
| Hong, YC | 1 |
| Chang, N | 1 |
| Jing, YF | 1 |
| Liu, SB | 1 |
| Ma, Z | 1 |
| Qin, C | 1 |
| Stratton, HJ | 1 |
| Sainath, SB | 1 |
| Sreenivasula Reddy, P | 1 |
| Jutabha, P | 1 |
| Anzai, N | 1 |
| Nicholson, H | 1 |
| Higuchi, TT | 1 |
| Palmer, JS | 1 |
| Gray, LE | 2 |
| Veeramachaneni, DN | 1 |
| Fisher, JS | 3 |
| Marchetti, N | 1 |
| Thompson, CJ | 1 |
| Ross, SM | 1 |
| Gaido, KW | 2 |
| Nakahara, H | 1 |
| Shono, T | 1 |
| Suita, S | 1 |
| Zhang, Y | 2 |
| Chen, B | 2 |
| Ding, X | 1 |
| Jiang, X | 2 |
| Lee, KY | 1 |
| Shibutani, M | 1 |
| Takagi, H | 1 |
| Kato, N | 1 |
| Takigami, S | 1 |
| Uneyama, C | 1 |
| Hirose, M | 1 |
| Mahood, IK | 4 |
| Hallmark, N | 4 |
| Walker, M | 3 |
| Borch, J | 1 |
| Axelstad, M | 1 |
| Vinggaard, AM | 1 |
| Dalgaard, M | 1 |
| Scott, H | 1 |
| Rivas, A | 1 |
| Hartung, S | 1 |
| Mason, JI | 1 |
| De Gendt, K | 1 |
| Verhoeven, G | 1 |
| O'Shaughnessy, P | 1 |
| Howdeshell, KL | 1 |
| Furr, J | 1 |
| Lambright, CR | 1 |
| Rider, CV | 1 |
| Wilson, VS | 1 |
| Brown, R | 1 |
| Ema, M | 1 |
| Miyawaki, E | 1 |
| Kawashima, K | 1 |
| Shultz, VD | 1 |
| Phillips, S | 1 |
| Sar, M | 1 |
| Foster, PM | 1 |
74 other studies available for dibutyl phthalate and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Maternal Perinatal Exposure to Dibutyl Phthalate Promotes Ovarian Dysfunction in Adult Female Offspring via Downregulation of TGF-β2 and TGF-β3.
Topics: Animals; Dibutyl Phthalate; Down-Regulation; Estradiol; Estrogen Receptor Antagonists; Female; Mater | 2022 |
Prenatal exposure to di(n-butyl) phthalate delays the spermatogenic cycle in rats: Investigation using a BrdU-injection method.
Topics: Animals; Bromodeoxyuridine; Dibutyl Phthalate; Female; Male; Phthalic Acids; Pregnancy; Prenatal Exp | 2022 |
Cord blood immune profile: Associations with higher prenatal plastic chemical levels.
Topics: Chemokine CXCL10; Child; Dibutyl Phthalate; Environmental Exposure; Environmental Pollutants; Female | 2022 |
Dibutyl phthalate exposure during gestation and lactation in C57BL/6 mice: Maternal behavior and neurodevelopment in pups.
Topics: Animals; Dibutyl Phthalate; Female; Humans; Lactation; Maternal Behavior; Maternal Exposure; Mice; M | 2020 |
In utero di-n-butyl phthalate exposure induced abnormal autophagy in renal tubular cells via hedgehog signaling in newborn rats.
Topics: Animals; Animals, Newborn; Autophagy; Cell Line; Dibutyl Phthalate; Female; Hedgehog Proteins; Kidne | 2020 |
Associations between prenatal phthalate exposure and sex-typed play behavior in preschool age boys and girls.
Topics: Child; Child Development; Child, Preschool; Dibutyl Phthalate; Environmental Exposure; Environmental | 2021 |
Intrauterine exposure to low-dose DBP in the mice induces obesity in offspring via suppression of UCP1 mediated ER stress.
Topics: Animals; Apoptosis; Body Composition; Dibutyl Phthalate; Endocrine Disruptors; Endoplasmic Reticulum | 2020 |
Systematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window.
Topics: Animals; Cryptorchidism; Dibutyl Phthalate; Dose-Response Relationship, Drug; Endocrine Disruptors; | 2020 |
A mixture of diethylhexyl, diisononyl and dibutyl phthalate decreased anogenital distance, postnatal testosterone levels, and changed social behavior in Wistar rats.
Topics: Animals; Animals, Newborn; Dibutyl Phthalate; Diethylhexyl Phthalate; Female; Genitalia; Male; Mater | 2020 |
Maternal Exposure to Dibutyl Phthalate (DBP) or Diethylstilbestrol (DES) Leads to Long-Term Changes in Hypothalamic Gene Expression and Sexual Behavior.
Topics: Animals; Aromatase; Dibutyl Phthalate; Diethylstilbestrol; Estrogens, Non-Steroidal; Female; Gonadot | 2021 |
Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats.
Topics: Animals; Dibutyl Phthalate; Disease Models, Animal; Environmental Pollutants; Erectile Dysfunction; | 2021 |
Environmentally relevant perinatal exposure to DBP disturbs testicular development and puberty onset in male mice.
Topics: Animals; Blood-Testis Barrier; Dibutyl Phthalate; Endocrine Disruptors; Female; Gonadal Steroid Horm | 2021 |
Alterations in prostate morphogenesis in male rat offspring after maternal exposure to Di-n-butyl-phthalate (DBP).
Topics: Androgen Antagonists; Animals; Bone Morphogenetic Protein 4; Dibutyl Phthalate; Environmental Pollut | 2017 |
Exposure to an Environmentally Relevant Phthalate Mixture Causes Transgenerational Effects on Female Reproduction in Mice.
Topics: Animals; Dibutyl Phthalate; Diethylhexyl Phthalate; Endocrine Disruptors; Environmental Exposure; En | 2017 |
Maternal exposure to di-n-butyl phthalate (DBP) induces renal fibrosis in adult rat offspring.
Topics: Animals; Apoptosis; Ascorbic Acid; Cell Proliferation; Dibutyl Phthalate; Disease Models, Animal; En | 2017 |
Prenatal exposure to di-n-butyl phthalate disrupts the development of adult Leydig cells in male rats during puberty.
Topics: Animals; Animals, Newborn; Dibutyl Phthalate; Dose-Response Relationship, Drug; Down-Regulation; Fem | 2017 |
Dibutyl phthalate induced testicular dysgenesis originates after seminiferous cord formation in rats.
Topics: Animals; Dibutyl Phthalate; Disease Models, Animal; Female; Fetus; Gonadal Dysgenesis; Humans; Leydi | 2017 |
In Utero Exposure to Di( n-butyl)phthalate Induces Morphological and Biochemical Changes in Rats Postpuberty.
Topics: Animals; Animals, Newborn; Dibutyl Phthalate; Female; Follicle Stimulating Hormone; Male; Maternal E | 2017 |
Potential involvement of Fgf10/Fgfr2 and androgen receptor (AR) in renal fibrosis in adult male rat offspring subjected to prenatal exposure to di-n-butyl phthalate (DBP).
Topics: Animals; Dibutyl Phthalate; Environmental Pollutants; Female; Fibroblast Growth Factor 10; Fibrosis; | 2018 |
Effects of gestational exposure to di-n-butyl phthalate and mineral oil on testis development of the Mongolian gerbil.
Topics: Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Dibutyl Phthalate; Endocrine Disru | 2018 |
Maternal exposure to di-n-butyl phthalate (DBP) promotes epithelial-mesenchymal transition via regulation of autophagy in uroepithelial cell.
Topics: Animals; Autophagy; Cells, Cultured; Dibutyl Phthalate; Epithelial-Mesenchymal Transition; Female; H | 2018 |
Maternal supplementation with corn oil associated or not with di-n-butyl phthalate increases circulating estradiol levels of gerbil offspring and impairs sperm reserve.
Topics: Animals; Corn Oil; Dibutyl Phthalate; Endocrine Disruptors; Estradiol; Female; Gerbillinae; Lipid Me | 2018 |
Association of Prenatal Phthalate Exposure With Language Development in Early Childhood.
Topics: Adolescent; Adult; Child, Preschool; Dibutyl Phthalate; Environmental Exposure; Female; Humans; Lang | 2018 |
Maternal exposure to di-n-butyl phthalate promotes Snail1-mediated epithelial-mesenchymal transition of renal tubular epithelial cells via upregulation of TGF-β1 during renal fibrosis in rat offspring.
Topics: Animals; Animals, Newborn; Cell Line; Dibutyl Phthalate; Down-Regulation; Epithelial Cells; Epitheli | 2019 |
Effects of in utero and lactational exposure to phthalates on reproductive development and glycemic homeostasis in rats.
Topics: Anal Canal; Animals; Blood Glucose; Dibutyl Phthalate; Diethylhexyl Phthalate; Female; Genitalia; Ho | 2019 |
Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes.
Topics: Animals; Aromatase; Dibutyl Phthalate; Diethylhexyl Phthalate; Environmental Pollutants; Estradiol; | 2019 |
Isolation and molecular characterization of spermatogonia from male Sprague-Dawley rats exposed
Topics: Acrylamide; Animals; Body Weight; Cell Differentiation; Cell Proliferation; Dibutyl Phthalate; Envir | 2019 |
Longitudinal Metabolic Impacts of Perinatal Exposure to Phthalates and Phthalate Mixtures in Mice.
Topics: Adipokines; Animals; Body Composition; Caenorhabditis elegans Proteins; Dibutyl Phthalate; Diethylhe | 2019 |
Male Sprague-Dawley rats exposed to in utero di(n-butyl) phthalate: dose dependent and age-related morphological changes in Leydig cell smooth endoplasmic reticulum.
Topics: Age Factors; Animals; Body Weight; Dibutyl Phthalate; Dose-Response Relationship, Drug; Endoplasmic | 2013 |
Neurotoxicity of dibutyl phthalate in brain development following perinatal exposure: a study in rats.
Topics: Age Factors; Animals; Apoptosis; Behavior, Animal; Caspase 3; Dibutyl Phthalate; Excitatory Postsyna | 2013 |
Effects of in utero exposure to di(n-butyl) phthalate for estrogen receptors α, β, and androgen receptor of Leydig cell on rats.
Topics: Animals; Dibutyl Phthalate; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Leydig Cells; M | 2014 |
Dibutyl phthalate-induced neurotoxicity in the brain of immature and mature rat offspring.
Topics: Age Factors; Animals; Aromatase; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Bind | 2014 |
Identification of gene expression changes in postnatal rat foreskin after in utero anti-androgen exposure.
Topics: Androgen Antagonists; Animals; Dibutyl Phthalate; Female; Flutamide; Foreskin; Gene Expression Regul | 2014 |
Genetic research and structural dysplasia assessment of anorectal malformations in neonatal male rats induced by di(n-butyl) phthalate.
Topics: Animals; Animals, Newborn; Anorectal Malformations; Anus, Imperforate; Dibutyl Phthalate; Female; Ge | 2016 |
Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice.
Topics: Animals; Apoptosis; Cell Differentiation; Dibutyl Phthalate; Diethylhexyl Phthalate; Environmental E | 2014 |
The mechanism underlying dibutyl phthalate induced shortened anogenital distance and hypospadias in rats.
Topics: Anal Canal; Animals; Biomarkers; Cryptorchidism; Dibutyl Phthalate; Dose-Response Relationship, Drug | 2015 |
Di-n-Butyl Phthalate Induces Multinucleated Germ Cells in the Rat Fetal Testis Through a Nonproliferative Mechanism.
Topics: Animals; Dibutyl Phthalate; Female; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Spragu | 2015 |
Male rats exposed in utero to di(n-butyl) phthalate: Age-related changes in Leydig cell smooth endoplasmic reticulum and testicular testosterone-biosynthesis enzymes/proteins.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Age Factors; Animals; Cell Shape; | 2016 |
[In utero exposure to di-n-butyl phthalate induces testicular cell apoptosis and vacuolization in the pubertal male rat offspring].
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Body Weight; Dibutyl Phthalate; Female; Immunohistoc | 2015 |
Prenatal exposure to di-n-butyl phthalate (DBP) differentially alters androgen cascade in undeformed versus hypospadiac male rat offspring.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Dibutyl Phthalate; Endocrine Disruptors; Female; Hyp | 2016 |
Maternal exposure to di-n-butyl phthalate (DBP) induces combined anorectal and urogenital malformations in male rat offspring.
Topics: Animals; Animals, Newborn; Anorectal Malformations; Dibutyl Phthalate; DNA-Binding Proteins; Female; | 2016 |
Protection of male reproductive toxicity in rats exposed to di-n-butyl phthalate during embryonic development by testosterone.
Topics: Animals; Dibutyl Phthalate; Embryonic Development; Female; Infertility, Male; Male; Organ Size; Preg | 2017 |
In utero exposure of high-dose di- n-butyl phthalate resulted in opposite effects on testicular cell apoptosis in late embryonic and pubertal male rat offspring.
Topics: Animals; Apoptosis; Cells, Cultured; Cryptorchidism; Dibutyl Phthalate; Disorders of Sex Development | 2017 |
Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the rat.
Topics: Age Factors; Androgens; Animals; Cell Count; Cell Division; Dibutyl Phthalate; Female; Immunohistoch | 2008 |
The orl rat with inherited cryptorchidism has increased susceptibility to the testicular effects of in utero dibutyl phthalate exposure.
Topics: Animals; Body Weight; Cryptorchidism; Dibutyl Phthalate; Disease Models, Animal; Dose-Response Relat | 2008 |
Diisobutyl phthalate impairs the androgen-dependent reproductive development of the male rat.
Topics: Administration, Oral; Animals; Dibutyl Phthalate; Dose-Response Relationship, Drug; Environmental Po | 2008 |
Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP).
Topics: Animals; Animals, Newborn; Bone Morphogenetic Proteins; Dibutyl Phthalate; Female; Fetal Development | 2009 |
Long-term effects of developmental exposure to di-n-butyl-phthalate (DBP) on rat prostate: proliferative and inflammatory disorders and a possible role of androgens.
Topics: Animals; Cell Proliferation; Dibutyl Phthalate; Epithelial Cells; Female; Gene Expression Regulation | 2009 |
Reproductive development and function of female rats exposed to di-eta-butyl-phthalate (DBP) in utero and during lactation.
Topics: Animals; Birth Weight; Dibutyl Phthalate; Female; Fertility; Fetal Weight; Lactation; Male; Ovary; P | 2010 |
Prenatal phthalate exposure and reduced masculine play in boys.
Topics: Child, Preschool; Dibutyl Phthalate; Diethylhexyl Phthalate; Environmental Exposure; Female; Gender | 2010 |
Androgen action in the masculinization programming window and development of male reproductive organs.
Topics: Androgen Antagonists; Androgens; Animals; Animals, Newborn; Dibutyl Phthalate; Female; Flutamide; Ge | 2010 |
Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat.
Topics: Animals; Dibutyl Phthalate; Female; Fetus; Flutamide; Immunohistochemistry; Male; Organ Size; Pregna | 2010 |
Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Anal Canal; Animals; Body Weight; Cryptorchidism; Dibutyl Pht | 2010 |
Effects of di(n-butyl) phthalate exposure on foetal rat germ-cell number and differentiation: identification of age-specific windows of vulnerability.
Topics: Animals; Cell Count; Cell Differentiation; Cell Proliferation; Dibutyl Phthalate; Female; Germ Cells | 2011 |
Prenatal exposure to phthalates and infant development at 6 months: prospective Mothers and Children's Environmental Health (MOCEH) study.
Topics: Adult; Child Development; Dibutyl Phthalate; Diethylhexyl Phthalate; Female; Humans; Infant; Male; N | 2011 |
Prenatal exposure to di-n-butyl phthalate induces anorectal malformations in male rat offspring.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anal Canal; Animals; Animals, Newborn; Body We | 2011 |
Prenatal di-n-butyl phthalate exposure alters reproductive functions at adulthood in male rats.
Topics: Animals; Dibutyl Phthalate; Female; Infertility, Male; Male; Pregnancy; Prenatal Exposure Delayed Ef | 2014 |
Atypical Leydig cell hyperplasia in adult rats with low T and high LH induced by prenatal Di(n-butyl) phthalate exposure.
Topics: Animals; Dibutyl Phthalate; Female; Histocytochemistry; Hyperplasia; Leydig Cells; Luteinizing Hormo | 2013 |
Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring.
Topics: Animals; Dibutyl Phthalate; Diethylstilbestrol; Endocrine Disruptors; Female; Gene Expression Regula | 2013 |
Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Female; Genitalia, Male; Male; Maternal Exp | 2003 |
Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate.
Topics: Age Factors; Animals; Body Weight; Dibutyl Phthalate; Disease Models, Animal; Female; Humans; Hyperp | 2003 |
Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholesterol; Dibutyl Phthalate; DNA-Binding Pr | 2004 |
[Effects of prenatal exposure to phthalate ester on both testicular descent and urogenital development in rats].
Topics: Animals; Cryptorchidism; Dibutyl Phthalate; Female; Hypospadias; Male; Pregnancy; Prenatal Exposure | 2003 |
[Reproductive and developmental toxicity of F1 male rats treated with DBP in utero and during lactation].
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Environmental Exposure; Female; Lactation; | 2004 |
Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dibutyl Phthalate; Epididymis; Female; Lactation; | 2004 |
Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation.
Topics: Animals; Body Weight; Dibutyl Phthalate; Diet; Endocrine Glands; Estrous Cycle; Female; Genitalia; G | 2004 |
Abnormal Leydig Cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis.
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Animals; Cell Aggregation; Dibutyl Phthalate; Fem | 2005 |
Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis.
Topics: Androgen Antagonists; Animals; Body Weight; Dibutyl Phthalate; Female; Fetal Development; Fetus; Imm | 2006 |
Cellular origins of testicular dysgenesis in rats exposed in utero to di(n-butyl) phthalate.
Topics: Androgen Antagonists; Animals; Dibutyl Phthalate; Disease Models, Animal; Female; Humans; Leydig Cel | 2006 |
Role of androgens in fetal testis development and dysgenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androgen Antagonists; Animals; Body Weight; Carcinogens; Dibutyl P | 2007 |
Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes.
Topics: Animals; Animals, Newborn; Cholesterol Side-Chain Cleavage Enzyme; Dibutyl Phthalate; Diethylhexyl P | 2007 |
In utero exposure to di(n-butyl) phthalate and testicular dysgenesis: comparison of fetal and adult end points and their dose sensitivity.
Topics: Animals; Cell Aggregation; Dibutyl Phthalate; Disease Models, Animal; Dose-Response Relationship, Dr | 2007 |
Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy.
Topics: Animals; Body Weight; Cryptorchidism; Dibutyl Phthalate; Embryonic and Fetal Development; Female; Ma | 2000 |
Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate.
Topics: Androgen Antagonists; Animals; Clusterin; Dibutyl Phthalate; Female; Fetus; Flutamide; Gene Expressi | 2001 |