dibutyl phthalate has been researched along with Abnormalities, Drug-Induced in 23 studies
Dibutyl Phthalate: A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.
dibutyl phthalate : A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In particular, the diethyl (DEP), di-n-propyl (DnPP), and di-n-butyl (DBP) phthalates were found to exert detrimental effects in both mammalian and non-mammalian studies, with toxic effects varying according to alkyl chain length." | 1.43 | Assessing differences in toxicity and teratogenicity of three phthalates, Diethyl phthalate, Di-n-propyl phthalate, and Di-n-butyl phthalate, using Xenopus laevis embryos. ( Burnham, N; Gardner, ST; Lester, R; Onkst, PE; Perygin, DH; Rayburn, J; Wood, AT, 2016) |
| "Timed-pregnant Sprague-Dawley rats were dosed with DBP at 500 mg/kg/day on gestation day (GD) 14 and 15, 15 and 16, 16 and 17, 17 and 18, 18 and 19, or 19 and 20 (GD 0=plug day)." | 1.33 | Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate. ( Carruthers, CM; Foster, PM, 2005) |
| " The NOAEL (no observable adverse effect level) for developmental toxicity of DBP was established based on pup body weight and male reproductive lesions at 50 mg/kg BW/day." | 1.32 | Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL. ( Chen, B; Jiang, X; Zhang, Y, 2004) |
| "Linuron, which is a weak competitive inhibitor of AR binding (reported Ki of 100 microM), alters sexual differentiation in an antiandrogenic manner." | 1.31 | Cellular and molecular mechanisms of action of linuron: an antiandrogenic herbicide that produces reproductive malformations in male rats. ( Bobseine, K; Gray, LE; Hotchkiss, AK; Lambright, C; Mann, PC; Ostby, J; Wilson, V, 2000) |
| " In conclusion, this study showed that DBP is a reproductive/developmental toxicant in Sprague-Dawley rats exposed both as adults and during development; it also indicates that the adverse reproductive/developmental effects of DBP on the second generation were greater than on the first generation." | 1.30 | Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats. ( Barnes, LH; Chapin, RE; Gulati, DK; Li, LH; Wine, RN, 1997) |
| " It was concluded that DBP administered during the second half of pregnancy produced adverse effects on the reproductive development in male fetuses." | 1.30 | Further evaluation of developmental toxicity of di-n-butyl phthalate following administration during late pregnancy in rats. ( Ema, M; Kawashima, K; Miyawaki, E, 1998) |
| " In the developmental toxicity study, dams were dosed with 0, 0." | 1.30 | Assessment of the developmental toxicity, metabolism, and placental transfer of Di-n-butyl phthalate administered to pregnant rats. ( Beydon, D; Fabry, JP; Gallissot, F; Langonne, I; Payan, JP; Sabate, JP; Saillenfait, AM, 1998) |
| "n-Butyl benzyl phthalate (BBP) and di-n-butyl phthalate (DBP) were evaluated and compared for their developmental toxic potential." | 1.29 | Comparative developmental toxicity of n-butyl benzyl phthalate and di-n-butyl phthalate in rats. ( Amano, H; Ema, M; Kurosaka, R; Ogawa, Y, 1995) |
| " Postimplantation loss was 100% for each period of dosing at 1." | 1.29 | Characterization of the developmental toxicity of di-n-butyl phthalate in rats. ( Amano, H; Ema, M; Ogawa, Y, 1994) |
| "The major malformations in treated groups were neural tube defects (exencephaly and myeloschisis), suggesting that the phthalic acid esters (PAEs) affect neural tube closure in developing embryos." | 1.26 | Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice. ( Nishimura, H; Shiota, K, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, Y | 1 |
| Gye, MC | 1 |
| Gardner, ST | 1 |
| Wood, AT | 1 |
| Lester, R | 1 |
| Onkst, PE | 1 |
| Burnham, N | 1 |
| Perygin, DH | 1 |
| Rayburn, J | 1 |
| Jiang, JT | 1 |
| Sun, WL | 1 |
| Jing, YF | 1 |
| Liu, SB | 1 |
| Ma, Z | 1 |
| Hong, Y | 1 |
| Ma, L | 1 |
| Qin, C | 1 |
| Liu, Q | 1 |
| Stratton, HJ | 1 |
| Xia, SJ | 1 |
| Dobrzyńska, MM | 1 |
| Tyrkiel, EJ | 1 |
| Pachocki, KA | 1 |
| Higuchi, TT | 1 |
| Palmer, JS | 1 |
| Gray, LE | 3 |
| Veeramachaneni, DN | 2 |
| Wilson, VS | 1 |
| Lambright, C | 2 |
| Furr, J | 1 |
| Ostby, J | 2 |
| Wood, C | 1 |
| Held, G | 1 |
| Zhang, Y | 2 |
| Chen, B | 2 |
| Ding, X | 1 |
| Jiang, X | 2 |
| Mahood, IK | 1 |
| Hallmark, N | 1 |
| McKinnell, C | 1 |
| Walker, M | 1 |
| Fisher, JS | 1 |
| Sharpe, RM | 1 |
| Carruthers, CM | 1 |
| Foster, PM | 2 |
| Lee, SK | 1 |
| Owens, GA | 1 |
| Shiota, K | 2 |
| Nishimura, H | 2 |
| Chou, MJ | 1 |
| Ema, M | 4 |
| Kurosaka, R | 1 |
| Amano, H | 3 |
| Ogawa, Y | 2 |
| Itami, T | 1 |
| Kawasaki, H | 1 |
| Wine, RN | 1 |
| Li, LH | 1 |
| Barnes, LH | 1 |
| Gulati, DK | 1 |
| Chapin, RE | 1 |
| Miyawaki, E | 1 |
| Kawashima, K | 1 |
| Saillenfait, AM | 2 |
| Payan, JP | 1 |
| Fabry, JP | 1 |
| Beydon, D | 1 |
| Langonne, I | 2 |
| Gallissot, F | 1 |
| Sabate, JP | 1 |
| Mylchreest, E | 1 |
| Sar, M | 1 |
| Cattley, RC | 1 |
| Bobseine, K | 1 |
| Wilson, V | 1 |
| Hotchkiss, AK | 1 |
| Mann, PC | 1 |
| Washam, C | 1 |
| Leheup, B | 1 |
23 other studies available for dibutyl phthalate and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Developmental toxicity of dibutyl phthalate and citrate ester plasticizers in Xenopus laevis embryos.
Topics: Abnormalities, Drug-Induced; Animals; Citrates; Dibutyl Phthalate; Embryo, Nonmammalian; Embryonic D | 2018 |
Assessing differences in toxicity and teratogenicity of three phthalates, Diethyl phthalate, Di-n-propyl phthalate, and Di-n-butyl phthalate, using Xenopus laevis embryos.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Embryo, Nonmammalian; Embryonic Development | 2016 |
Prenatal exposure to di-n-butyl phthalate induces anorectal malformations in male rat offspring.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anal Canal; Animals; Animals, Newborn; Body We | 2011 |
Developmental toxicity in mice following paternal exposure to Di-N-butyl-phthalate (DBP).
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Female; Male; Mice; Paternal Exposure; Plas | 2011 |
Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Female; Genitalia, Male; Male; Maternal Exp | 2003 |
Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis.
Topics: Abnormalities, Drug-Induced; Androgen Receptor Antagonists; Animals; Dibutyl Phthalate; Diethylhexyl | 2004 |
[Reproductive and developmental toxicity of F1 male rats treated with DBP in utero and during lactation].
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Environmental Exposure; Female; Lactation; | 2004 |
Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dibutyl Phthalate; Epididymis; Female; Lactation; | 2004 |
Abnormal Leydig Cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis.
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Animals; Cell Aggregation; Dibutyl Phthalate; Fem | 2005 |
Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Female; Genitalia, Male; Male; Maternal Exp | 2005 |
Exposure to low concentrations of di-n-butyl phthalate during embryogenesis reduces survivability and impairs development of Xenopus laevis frogs.
Topics: Abnormalities, Drug-Induced; Animals; Cell Survival; Dibutyl Phthalate; Dose-Response Relationship, | 2005 |
Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Dibutyl Phthalate; Diethylhexyl P | 1982 |
Embryotoxic effects of di-2-ethylhexyl phthalate (DEHP) and di-n-buty phthalate (DBP) in mice.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Diethylhexyl Phthalate; Female; Fetal Death | 1980 |
Comparative developmental toxicity of n-butyl benzyl phthalate and di-n-butyl phthalate in rats.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Embryo Loss; Embryonic and Fetal Developmen | 1995 |
Characterization of the developmental toxicity of di-n-butyl phthalate in rats.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Cleft Palate; Dibutyl Phthalate; Dose-Response | 1994 |
Teratogenic evaluation of di-n-butyl phthalate in rats.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Female; Fetus; Pregnancy; Rats; Rats, Wista | 1993 |
Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dibutyl Phthalate; Female; Fertility; Male; Penis | 1997 |
Further evaluation of developmental toxicity of di-n-butyl phthalate following administration during late pregnancy in rats.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Body Weight; Dibutyl Phthalate; Diet; Eating | 1998 |
Assessment of the developmental toxicity, metabolism, and placental transfer of Di-n-butyl phthalate administered to pregnant rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Amniotic Fluid; Animals; Area Under Curve; Cleft | 1998 |
Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide.
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Androgens; Animals; Animals, Newborn; Cryptorchid | 1999 |
Cellular and molecular mechanisms of action of linuron: an antiandrogenic herbicide that produces reproductive malformations in male rats.
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Animals; COS Cells; Dibutyl Phthalate; Dihydrotes | 2000 |
Baby ills from beauty aids?
Topics: Abnormalities, Drug-Induced; Animals; Consumer Product Safety; Cosmetics; Dibutyl Phthalate; Environ | 2001 |
Effects of mono-n-butyl phthalate on the development of rat embryos: in vivo and in vitro observations.
Topics: Abnormalities, Drug-Induced; Animals; Dibutyl Phthalate; Dose-Response Relationship, Drug; Embryo, M | 2001 |