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dibucaine and Apnea

dibucaine has been researched along with Apnea in 36 studies

Dibucaine: A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
cinchocaine : A monocarboxylic acid amide that is the 2-(diethylamino)ethyl amide of 2-butoxyquinoline-4-carboxylic acid. One of the most potent and toxic of the long-acting local anesthetics, its parenteral use was restricted to spinal anesthesia. It is now generally only used (usually as the hydrochloride) in creams and ointments and in suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.

Apnea: A transient absence of spontaneous respiration.

Research Excerpts

ExcerptRelevanceReference
"8) Abnormal variants of serum cholinesterase lead to prolonged apnea."7.67[Phenotype of plasma cholinesterase in prolonged apnea and sensitivity to succinylcholine]. ( Alcalay, A; Burnat, P; Jacquot, C; Zaoui, P, 1987)
" Homozygotes for the A gene product are at risk for prolonged apnea following exposure to the surgical anesthetics succinylcholine or mivacurium."3.74Molecular basis of succinylcholine sensitivity in a prairie Hutterite kindred and genetic characterization of the region containing the BCHE gene. ( Coghlan, G; Mauthe, J; Triggs-Raine, B; Zelinski, T, 2007)
" On the other hand, the two methods using butyrylthiocholine as substrate and that employing benzoylcholine showed limited clinical utility in discriminating subjects at risk of prolonged apnea (area under the ROC curve < or = 0."3.72Assay using succinyldithiocholine as substrate: the method of choice for the measurement of cholinesterase catalytic activity in serum to diagnose succinyldicholine sensitivity. ( Bonora, R; Ceriotti, F; Franzini, C; Lando, G; Mosca, A; Panteghini, M; Patrosso, MC; Zaninotto, M, 2003)
"8) Abnormal variants of serum cholinesterase lead to prolonged apnea."3.67[Phenotype of plasma cholinesterase in prolonged apnea and sensitivity to succinylcholine]. ( Alcalay, A; Burnat, P; Jacquot, C; Zaoui, P, 1987)
"The fluoride numbers (FN) of 144 individuals referred to our laboratory for dibucaine number (DN) determinations because of prolonged apnea following succinylcholine in the probands or relatives were determined by our new method using 2."3.66Floride inhibition in patients with atypical dibucaine-resistant plasmacholinesterase. ( Flynn, KB; Kothary, SP; Zsigmond, EK, 1979)
" Because of these reports, 23 patients with prolonged apnea after administration of succinylcholine were studied with Kalow's method for abnormal dibucaine number (DN), which characterizes this condition, and for the history of local anesthetic toxicity."3.65Survey of local anesthetic toxicity in the families of patients with atypical plasma cholinesterase. ( Eilderton, TE; Zsigmond, EK, 1975)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199032 (88.89)18.7374
1990's2 (5.56)18.2507
2000's2 (5.56)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mosca, A1
Bonora, R1
Ceriotti, F1
Franzini, C1
Lando, G1
Patrosso, MC1
Zaninotto, M1
Panteghini, M1
NIXON, JC1
THIEL, CJ1
Zelinski, T1
Coghlan, G1
Mauthe, J1
Triggs-Raine, B1
Brown, SS2
Kalow, W1
Pilz, W1
Whittaker, M4
Woronick, CL1
Pasquariello, CA1
Schwartz, RE1
Simeon-Rudolf, V1
Kovarik, Z1
Skrinjarić-Spoljar, M1
Evans, RT2
Agarwal, DP1
Schwenkenbecher, S1
Srivastava, LM1
Goedde, HW1
Gerosky, T1
O'Leary, J1
Hunt, R1
Hutchinson, MA1
Kothary, SP1
Flynn, KB1
Zsigmond, EK3
Geshelin, SA1
Viby-Mogensen, J1
Hanel, HK1
Eilderton, TE1
Baraka, A1
Haroun, S1
Bassili, M1
Abu-Haider, G1
Pronk, IR1
van der Wal, SJ1
Thé, TH1
Burnat, P1
Jacquot, C1
Alcalay, A1
Zaoui, P1
Ukoha, AI1
Nwoke, UN1
Rahman, MM1
Alam, MS1
Nelson, TC1
Burritt, MF1
Bauld, HW1
Gibson, PF1
Jebson, PJ1
Richardson, RB1
Smith, JC1
Derrick, WS1
Liddell, J1
Mone, JG1
Mathie, WE1
Peck, AW1
Fishtal, A1
Chapman, CN1
McLellan, GH1
Billings, JD1
Litwiller, RW1
King, J1
Morgan, HG1
Vickers, MD1
Vetten, KB1
Downs, JR1
Zoerb, DL1
Dietz, AA1
Lubrano, T1
Rubinstein, HM1
Szeinberg, A1
Pipano, S1
Ostfeld, E1
Hunter, AR2
Thompson, JC1

Reviews

2 reviews available for dibucaine and Apnea

ArticleYear
The plasma cholinesteerases: a new perspective.
    Advances in clinical chemistry, 1981, Volume: 22

    Topics: Acetylcholinesterase; Anesthesia, General; Apnea; Cholinesterases; Dibucaine; Fluorides; Genes; Gene

1981
Pharmacogenetics. Cholinesterase variants and suxamethonium apnoea.
    Proceedings of the Royal Society of Medicine, 1968, Volume: 61, Issue:2

    Topics: Alleles; Apnea; Cholinesterase Inhibitors; Cholinesterases; Dibucaine; Drug Hypersensitivity; Electr

1968

Other Studies

34 other studies available for dibucaine and Apnea

ArticleYear
Assay using succinyldithiocholine as substrate: the method of choice for the measurement of cholinesterase catalytic activity in serum to diagnose succinyldicholine sensitivity.
    Clinical chemistry and laboratory medicine, 2003, Volume: 41, Issue:3

    Topics: Anesthetics, Local; Apnea; Butyrylthiocholine; Cariostatic Agents; Catalysis; Cholinesterase Inhibit

2003
APNEA DUE TO INHERITANCE OF ATYPICAL PSEUDOCHOLINESTERASE.
    Canadian Medical Association journal, 1964, May-09, Volume: 90

    Topics: Abscess; Anesthesia; Anesthesia, General; Anesthesiology; Apnea; Butyrylcholinesterase; Cholinestera

1964
Molecular basis of succinylcholine sensitivity in a prairie Hutterite kindred and genetic characterization of the region containing the BCHE gene.
    Molecular genetics and metabolism, 2007, Volume: 90, Issue:2

    Topics: Apnea; Butyrylcholinesterase; Canada; Dibucaine; Ethnicity; Female; Genetics, Population; Humans; Ma

2007
Plasma cholinesterase deficiency in a neonate: a follow-up.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:4

    Topics: Apnea; Child, Preschool; Cholinesterases; Dibucaine; Female; Follow-Up Studies; Humans; Infant, Newb

1995
An explanation for the different inhibitory characteristics of human serum butyrylcholinesterase phenotypes deriving from inhibition of atypical heterozygotes.
    Chemico-biological interactions, 1999, May-14, Volume: 119-120

    Topics: Apnea; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Dibucaine; Genetic Carrier Scre

1999
[A spectrophotometric method for the determination of serum cholinesterase variants with succinyl choline as substrate (author's transl)].
    Zeitschrift fur klinische Chemie und klinische Biochemie, 1975, Volume: 13, Issue:4

    Topics: Anesthesia; Animals; Apnea; Choline; Cholinesterase Inhibitors; Cholinesterases; Cytochrome c Group;

1975
Prolonged apnea of an oral surgery patient after administration of succinylcholine.
    Journal of oral surgery (American Dental Association : 1965), 1979, Volume: 37, Issue:6

    Topics: Adolescent; Anesthesia, Dental; Anesthesia, General; Apnea; Butyrylcholinesterase; Cholinesterase In

1979
Floride inhibition in patients with atypical dibucaine-resistant plasmacholinesterase.
    Biochemical genetics, 1979, Volume: 17, Issue:11-12

    Topics: Apnea; Choline O-Acetyltransferase; Dibucaine; Drug Resistance; Fluorides; Genotype; Heterozygote; H

1979
[Peripheral paralysis or "bulbar threat"? (Further comment on the pathogenesis of respiratory arrest and vascular collapse during cerebrospinal anesthesia)].
    Vestnik khirurgii imeni I. I. Grekova, 1978, Volume: 121, Issue:7

    Topics: Anesthesia, Spinal; Animals; Apnea; Blood Pressure; Bulbar Palsy, Progressive; Dibucaine; Dogs; Hear

1978
A Danish cholinesterase research unit.
    Acta anaesthesiologica Scandinavica, 1977, Volume: 21, Issue:5

    Topics: Apnea; Cholinesterases; Denmark; Dibucaine; Female; Genetic Variation; Genotype; Humans; Male; Pedig

1977
Survey of local anesthetic toxicity in the families of patients with atypical plasma cholinesterase.
    Journal of oral surgery (American Dental Association : 1965), 1975, Volume: 33, Issue:11

    Topics: Anesthetics, Local; Apnea; Benzoylcholine; Cholinesterases; Dibucaine; Heterozygote; Homozygote; Hum

1975
Response of the newborn to succinlycholine injection in homozygotic atypical mothers.
    Anesthesiology, 1975, Volume: 43, Issue:1

    Topics: Adult; Anesthesia, Intravenous; Anesthesia, Obstetrical; Apnea; Cesarean Section; Cholinesterases; D

1975
[Familial examinations for the presence of atypical cholinesterase].
    Nederlands tijdschrift voor geneeskunde, 1975, Oct-04, Volume: 119, Issue:40

    Topics: Adolescent; Anesthesia, General; Apnea; Appendectomy; Child, Preschool; Cholinesterase Inhibitors; C

1975
[Phenotype of plasma cholinesterase in prolonged apnea and sensitivity to succinylcholine].
    Cahiers d'anesthesiologie, 1987, Volume: 35, Issue:8

    Topics: Anesthesia, General; Apnea; Cholinesterase Inhibitors; Dibucaine; Family; Female; Humans; Phenotype;

1987
The prevalence of atypical serum cholinesterase in a Nigerian population.
    Tropical and geographical medicine, 1987, Volume: 39, Issue:2

    Topics: Alleles; Anemia, Sickle Cell; Apnea; Butyrylcholinesterase; Cholinesterases; Dibucaine; Fluorides; G

1987
Pesticide poisoning, succinylcholine-induced apnea, and pseudocholinesterase.
    Mayo Clinic proceedings, 1986, Volume: 61, Issue:9

    Topics: Apnea; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Dibucaine; Humans; Pestici

1986
Aetiology of prolonged apnoea after suxamethonium.
    British journal of anaesthesia, 1974, Volume: 46, Issue:4

    Topics: Adolescent; Adult; Aged; Apnea; Catalysis; Child; Child, Preschool; Cholinesterases; Dibucaine; Drug

1974
Atypical plasma cholinesterase, succinylcholine, and prolonged apnea.
    Southern medical journal, 1974, Volume: 67, Issue:9

    Topics: Aged; Anesthesia; Apnea; Cholinesterases; Dibucaine; Female; Humans; Succinylcholine; Time Factors

1974
Qualitative defects of pseudocholinesterase activity.
    Anaesthesia, 1967, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Aged; Apnea; Child; Cholinesterases; Clinical Enzyme Tests; Cyclophosphamide; Dib

1967
Aspects of suxamethonium hydrolysis in man and animals.
    Proceedings of the Royal Society of Medicine, 1970, Volume: 63, Issue:2

    Topics: Acetylcholine; Acetylcholinesterase; Alleles; Animals; Apnea; Cats; Cholinesterase Inhibitors; Choli

1970
An original approach to the diagnosis of scoline-induced apnoea.
    Journal of clinical pathology, 1972, Volume: 25, Issue:5

    Topics: Apnea; Cholinesterases; Dibucaine; Heterozygote; Homozygote; Humans; Hydrogen-Ion Concentration; Hyd

1972
Suxamethonium sensitivity.
    The New Zealand medical journal, 1967, Volume: 66, Issue:415

    Topics: Anesthesia, General; Apnea; Blood Transfusion; Child; Cholinesterases; Dibucaine; Drug Hypersensitiv

1967
A family study of atypical plasma cholinesterase activity.
    Southern medical journal, 1970, Volume: 63, Issue:7

    Topics: Adult; Apnea; Child; Cholinesterases; Clinical Enzyme Tests; Diagnosis, Differential; Dibucaine; Fem

1970
The temperature activity relationships of serum cholinesterases.
    Journal of clinical pathology, 1970, Volume: 23, Issue:8

    Topics: Apnea; Cholinesterase Inhibitors; Cholinesterases; Dibucaine; Fluorides; Humans; Phenotype; Succinyl

1970
Initial experiences with the Cholinesterase Research Unit.
    British journal of anaesthesia, 1970, Volume: 42, Issue:11

    Topics: Apnea; Child; Cholinesterases; Dibucaine; Female; Fluorides; Genotype; Heterozygote; Humans; Male; M

1970
Genetics--the anaesthetist at risk.
    South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie, 1970, Volume: 8, Issue:4

    Topics: Apnea; Barbiturates; Dibucaine; Female; Fever; Humans; Hydrocarbons, Halogenated; Male; Nitrous Oxid

1970
Plasma cholinesterase activity in newborns and infants.
    Canadian Anaesthetists' Society journal, 1971, Volume: 18, Issue:3

    Topics: Apnea; Cholinesterase Inhibitors; Cholinesterases; Dibucaine; Female; Halothane; Heart Block; Humans

1971
Atypical pseudocholinesterase activity: a review and presentation of two cases.
    Canadian Anaesthetists' Society journal, 1968, Volume: 15, Issue:2

    Topics: Aged; Apnea; Cholinesterase Inhibitors; Cholinesterases; Dibucaine; Female; Genetics, Medical; Human

1968
An additional pseudocholinesterase phenotype occurring in suxamethonium apnoea.
    British journal of anaesthesia, 1968, Volume: 40, Issue:8

    Topics: Apnea; Chlorides; Cholinesterases; Clinical Enzyme Tests; Dibucaine; Fluorides; Humans; Middle Aged;

1968
Four families segregating for the silent gene for serum cholinesterase.
    Acta genetica et statistica medica, 1965, Volume: 15, Issue:3

    Topics: Adult; Apnea; Appendectomy; Child; Cholinesterases; Dibucaine; Enzymes; Female; Genes; Humans; Pulmo

1965
A silent pseudocholinesterase gene. Marked suxamethonium sensitivity in a person heterozygous for the atypical and silent pseudocholinesterase genes.
    Acta genetica et statistica medica, 1965, Volume: 15, Issue:3

    Topics: Apnea; Blood Chemical Analysis; Cholinesterases; Dibucaine; Enzymes; Fluorides; Genes; Humans; Middl

1965
Prolongation of the action of suxamethonium. A clinical investigation.
    Anaesthesia, 1966, Volume: 21, Issue:3

    Topics: Acridines; Anesthesia, Endotracheal; Apnea; Blood Chemical Analysis; Cholinesterases; Dibucaine; Enz

1966
Suxamethonium apnoea. A study of eighteen cases.
    Anaesthesia, 1966, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Aged; Anesthesia, General; Apnea; Child; Child, Preschool; Cholinesterases; Dibuc

1966
A study of the pseudocholinesterase in 78 cases of apnoea following suxamethonium.
    Acta genetica et statistica medica, 1966, Volume: 16, Issue:3

    Topics: Apnea; Chlorides; Cholinesterases; Dibucaine; Drug Hypersensitivity; Fluorides; Genes; Humans; Succi

1966