dibekacin and Apnea

The curarizing effect of three new aminoglucosidic antibiotics (amikacine, dibékacine and sisomicine) is compared to that the streptomycin. The experiment was carried out on mice. In the first group of experiments, the curare-like action of increasing doses of the antibiotics is studied on a diaphragm-phrenic nerve preparation. In the second group, the dosage of each antibiotic necessary to induce apnea is sought. The results show that all the antibiotics have a curarizing activity, variable according to the product, and which increases with the doses used. The relationship between the therapeutic doses and the curarizing doses had a greater margin of security with the three antibiotics than with streptomycin.

Topics: Amikacin; Animals; Apnea; Dibekacin; Dose-Response Relationship, Drug; Gentamicins; Kanamycin; Mice; Neuromuscular Blocking Agents; Phrenic Nerve; Sisomicin; Streptomycin