dibekacin and Abscess

A case of methicillin-resistant Staphylococcus aureus (MRSA)-pyomyositis in association with acute myelogenous leukemia (AML) is reported. MRSA-sepsis developed in a 51-year-old Japanese man with AML, during the neutropenic period after high-dose 1-beta-d-arabinofuranosylcytosine (Ara-C). Although the MRSA-sepsis initially improved with arbekacin sulfate (ABK) administration, a high fever recurred with left thigh pain despite recovery of the neutrophil count after ABK was stopped. A computed tomographic (CT) scan showed a low-density area in the left quadriceps femoris muscle, which led to a diagnosis of pyomyositis. MRSA was cultured from the abscess aspirates. The fever and thigh pain disappeared after administration of ABK and minocycline hydrochloride (MINO), and the abscess completely disappeared with the oral administration of levofloxacin (LVFX) for about 3 months.. If an immunocompromised patient complains of fever and muscle pain after intensive chemotherapy, MRSA-pyomyositis should be considered.

Topics: Abscess; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Dibekacin; Fever; Humans; Immunocompromised Host; Leukemia, Myeloid, Acute; Male; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Pyomyositis; Remission Induction; Staphylococcal Infections

We reported a case of abscess in which Serratia marcescens was isolated as the causative organism. We measured the postantibiotic effect (PAE) of dibekacin (DKB) and gentamicin (GM) against S. marcescens and studied the relationship between the clinical effect and the PAE. The minimal inhibitory concentration (MIC) of DKB against S. marcescens was 6.25 micrograms/mL and the serum concentration 30 min after infusion of 100 mg DKB was 5.99 micrograms/mL. The abscess was cured by the administration of DKB every 12 h. The PAE in vivo was 2.5, 2.9 and 3.3 h when DKB was administered at 50 mg/kg, 100 mg/kg and 200 mg/kg, respectively. This PAE is one of the reasons that infection can be effectively treated with intermittent administration, even if the serum concentration is below the MIC.

Topics: Abscess; Adolescent; Ampicillin; Anti-Bacterial Agents; Cephamycins; Cloxacillin; Dibekacin; Drug Administration Schedule; Drug Therapy, Combination; Gentamicins; Humans; Male; Serratia Infections; Serratia marcescens

A contaminated catheter used in epidural anesthesia in a 71-year-old female produced acute epidural abscess and septic meningitis. Methicillin-resistant Staphylococcus aureus (MRSA) was detected in a culture of the epidural pus. Both T1- and T2-weighted MR images showed low intensity mass lesion compressing the thecal sac behind the vertebral body L3. The low intensity lesion was probably pus with gas component. In these low intensity lesions in MR findings with gas component, MR was superior to myelography because it visualized both the degree of compression to the thecal sac and extension of the lesion in all directions.

Topics: Abscess; Acyclovir; Aged; Aminoglycosides; Anesthesia, Epidural; Anti-Bacterial Agents; Dibekacin; Drug Therapy, Combination; Epidural Space; Female; Herpes Zoster; Humans; Iatrogenic Disease; Imipenem; Magnetic Resonance Imaging; Meningitis, Bacterial; Myelography; Neuralgia; Palliative Care; Spinal Diseases; Staphylococcal Infections

We report the case of a young woman who had undergone a difficult emergency intubation and rapidly developed a mediastinal collection of pus. Mediastinoscopy, requested for diagnostic purposes, was also therapeutic as it drained the abscess. The patient received a course of antibiotics and was cured without sequelae. Accidents of tracheal intubation are severe, especially when unrecognized. They often include perforation of the oesophagus resulting in mediastinitis or abscess with an estimated 30 to 40% mortality rate, and they constitute a medico-surgical emergency. In the case reported here mediastinoscopy was crucial, but the theoretical value of computerized tomography must be stressed since this method not only detects the lesion but is also used to perform a guided drainage.

Topics: Abscess; Adult; Dibekacin; Female; Humans; Intubation, Intratracheal; Mediastinal Diseases; Mediastinoscopy; Penicillin G

The in vitro and in vivo antibacterial activities of a new aminoglycoside antibiotic, arbekacin (HBK), against methicillin-cephem-resistant Staphylococcus aureus (MRSA) were compared with those of gentamicin (GM), netilmicin (NTL) and amikacin (AMK). The results obtained were summarized as follows: Compared to other aminoglycoside antibiotics, HBK had the highest antibacterial activities against clinically isolated MRSA (46 strains). Therapeutic effects of HBK against experimental systemic infections with MRSA in mice, were superior to those of GM, NTL and AMK. The ED50's of GM, NTL and AMK were more than 2 mg/mouse. Therapeutic effects of HBK against experimental subcutaneous infections with MRSA in mice were also superior to those of GM, NTL and AMK.

Topics: Abscess; Aminoglycosides; Animals; Anti-Bacterial Agents; Bacterial Infections; Cephalosporins; Dibekacin; Kanamycin; Male; Methicillin; Mice; Penicillin Resistance; Skin Diseases; Staphylococcus aureus

Synergistic effects of immune gamma-globulin fraction containing antibodies of OPE, protease and elastase of Pseudomonas aeruginosa on the activities of antibiotic, dibekacin (DKB), in the cornea of mice were examined for the purpose of studying therapy for corneal ulcers due to Pseudomonal infection. In the case of the intramuscular injection, a medium effective dose (ED50) of DKB alone against corneal ulcers caused by strain IID 1210 of P. aeruginosa in experimental mice was 620 mug per mouse. When 15.6 to 18.7 mg of gamma-globulin fraction was subcutaneously given to each mouse prior to the infection with strain IID 1210, opacity instead of severe ulcers was observed only in the central area of cornea. The immune gamma-globulin fraction was far more effective in the protection of cornea from the infection than the calf serum that showed no antibody titer against OEP, protease and elastase. The ED50 values of DKB's combined with the immune gamma-globulin, Fr. 1 and Fr. 2, and the calf serum were 34 and 73, and 480 mug per mouse respectively. There was found no statistical difference in ED50 value between DKB combined with the calf serum and one without it. There was, however, significant difference in ED50 value between DKB's combined with Fr. 1 and Fr. 2, and one with the calf serum. When DKB alone is dropped in the eye of mouse for the protection, the ED50 value was 15 mug per mouse. When 1.56 to 1.87 mg of the immune gamma-globulin fraction was dropped in the eye after the infection with P. aeruginosa, there was observed no protection against corneal ulcers. the ED50 values of DKB's combined with Fr. 1, Fr. 2 and the calf serum were 0.96, 0.94 and 13 mug per mouse, respectively. There was no significant difference between the ED50 values of 0.96 and 0.94 mug, and between 15 and 18 mug. There was, however, significant difference between the former ED50 values (0.96 and 0.94 mug) and the latter ones (15 and 18 mug). The combination of DKB and the immune gamma-globulin fraction was found to be superior to the combination of DKB and the calf serum in the therapeutic effect on corneal ulcers caused by strain IID 1210 of P. aeruginosa.

Topics: Abscess; Animals; Antibodies, Bacterial; Antigens, Bacterial; Corneal Opacity; Corneal Ulcer; Dibekacin; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Immune Sera; Immunoglobulin G; Kanamycin; Mice; Pseudomonas aeruginosa; Pseudomonas Infections