Page last updated: 2024-10-25

diazoxide and Weight Loss

diazoxide has been researched along with Weight Loss in 4 studies

Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.

Weight Loss: Decrease in existing BODY WEIGHT.

Research Excerpts

ExcerptRelevanceReference
"Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men."9.27High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018)
" The aim of the present study was to investigate the effect of inhibition of insulin secretion by diazoxide on weight loss in obese, normoglycaemic (fasting plasma glucose of > or =6."9.12No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet. ( Astrup, A; Due, A; Eriksen, G; Flint, A; Hansen, JB; Møller, B; Raben, A, 2007)
"To examine the concept whether high-dose diazoxide (DZX)-mediated insulin suppression, in combination with moderate caloric restriction and increased physical activity, can establish a weight loss of at least 15% in obese hyperinsulinaemic men."7.74Weight loss in obese men by caloric restriction and high-dose diazoxide-mediated insulin suppression. ( de Boer, H; Loves, S; Rijnders, T; Ruinemans-Koerts, J; van Boekel, G; van Sorge, A, 2008)
"Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men."5.27High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018)
" The aim of the present study was to investigate the effect of inhibition of insulin secretion by diazoxide on weight loss in obese, normoglycaemic (fasting plasma glucose of > or =6."5.12No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet. ( Astrup, A; Due, A; Eriksen, G; Flint, A; Hansen, JB; Møller, B; Raben, A, 2007)
"To examine the concept whether high-dose diazoxide (DZX)-mediated insulin suppression, in combination with moderate caloric restriction and increased physical activity, can establish a weight loss of at least 15% in obese hyperinsulinaemic men."3.74Weight loss in obese men by caloric restriction and high-dose diazoxide-mediated insulin suppression. ( de Boer, H; Loves, S; Rijnders, T; Ruinemans-Koerts, J; van Boekel, G; van Sorge, A, 2008)
"The role of hyperinsulinemia as a possible preceding event in the development of obesity has been proposed."2.69Beneficial effect of diazoxide in obese hyperinsulinemic adults. ( Alemzadeh, R; Langley, G; Slonim, AE; Smith, P; Upchurch, L, 1998)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Loves, S2
van Groningen, L1
Filius, M1
Mekking, M1
Brandon, T1
Tack, CJ1
Hermus, A1
de Boer, H2
Due, A1
Flint, A1
Eriksen, G1
Møller, B1
Raben, A1
Hansen, JB1
Astrup, A1
van Boekel, G1
van Sorge, A1
Ruinemans-Koerts, J1
Rijnders, T1
Alemzadeh, R1
Langley, G1
Upchurch, L1
Smith, P1
Slonim, AE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Diazoxide-mediated Insulin Suppression in Hyperinsulinemic Obese Men, Part III[NCT00631033]Phase 251 participants (Actual)Interventional2008-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for diazoxide and Weight Loss

ArticleYear
High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention.
    The Journal of clinical endocrinology and metabolism, 2018, 11-01, Volume: 103, Issue:11

    Topics: Adult; Blood Glucose; Body Mass Index; Body Weight; Diazoxide; Dose-Response Relationship, Drug; Dou

2018
No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet.
    Diabetes, obesity & metabolism, 2007, Volume: 9, Issue:4

    Topics: Adult; Blood Glucose; C-Peptide; Counseling; Diazoxide; Diet, Reducing; Double-Blind Method; Energy

2007
Beneficial effect of diazoxide in obese hyperinsulinemic adults.
    The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:6

    Topics: Adult; Body Composition; Body Mass Index; Body Weight; Diazoxide; Diet, Reducing; Energy Intake; Fem

1998

Other Studies

1 other study available for diazoxide and Weight Loss

ArticleYear
Weight loss in obese men by caloric restriction and high-dose diazoxide-mediated insulin suppression.
    Diabetes, obesity & metabolism, 2008, Volume: 10, Issue:12

    Topics: Adult; Body Composition; Caloric Restriction; Diazoxide; Diet, Reducing; Dose-Response Relationship,

2008