diazoxide has been researched along with Weight Loss in 4 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Weight Loss: Decrease in existing BODY WEIGHT.
Excerpt | Relevance | Reference |
---|---|---|
"Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men." | 9.27 | High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018) |
" The aim of the present study was to investigate the effect of inhibition of insulin secretion by diazoxide on weight loss in obese, normoglycaemic (fasting plasma glucose of > or =6." | 9.12 | No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet. ( Astrup, A; Due, A; Eriksen, G; Flint, A; Hansen, JB; Møller, B; Raben, A, 2007) |
"To examine the concept whether high-dose diazoxide (DZX)-mediated insulin suppression, in combination with moderate caloric restriction and increased physical activity, can establish a weight loss of at least 15% in obese hyperinsulinaemic men." | 7.74 | Weight loss in obese men by caloric restriction and high-dose diazoxide-mediated insulin suppression. ( de Boer, H; Loves, S; Rijnders, T; Ruinemans-Koerts, J; van Boekel, G; van Sorge, A, 2008) |
"Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men." | 5.27 | High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018) |
" The aim of the present study was to investigate the effect of inhibition of insulin secretion by diazoxide on weight loss in obese, normoglycaemic (fasting plasma glucose of > or =6." | 5.12 | No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet. ( Astrup, A; Due, A; Eriksen, G; Flint, A; Hansen, JB; Møller, B; Raben, A, 2007) |
"To examine the concept whether high-dose diazoxide (DZX)-mediated insulin suppression, in combination with moderate caloric restriction and increased physical activity, can establish a weight loss of at least 15% in obese hyperinsulinaemic men." | 3.74 | Weight loss in obese men by caloric restriction and high-dose diazoxide-mediated insulin suppression. ( de Boer, H; Loves, S; Rijnders, T; Ruinemans-Koerts, J; van Boekel, G; van Sorge, A, 2008) |
"The role of hyperinsulinemia as a possible preceding event in the development of obesity has been proposed." | 2.69 | Beneficial effect of diazoxide in obese hyperinsulinemic adults. ( Alemzadeh, R; Langley, G; Slonim, AE; Smith, P; Upchurch, L, 1998) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (25.00) | 18.2507 |
2000's | 2 (50.00) | 29.6817 |
2010's | 1 (25.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Loves, S | 2 |
van Groningen, L | 1 |
Filius, M | 1 |
Mekking, M | 1 |
Brandon, T | 1 |
Tack, CJ | 1 |
Hermus, A | 1 |
de Boer, H | 2 |
Due, A | 1 |
Flint, A | 1 |
Eriksen, G | 1 |
Møller, B | 1 |
Raben, A | 1 |
Hansen, JB | 1 |
Astrup, A | 1 |
van Boekel, G | 1 |
van Sorge, A | 1 |
Ruinemans-Koerts, J | 1 |
Rijnders, T | 1 |
Alemzadeh, R | 1 |
Langley, G | 1 |
Upchurch, L | 1 |
Smith, P | 1 |
Slonim, AE | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Diazoxide-mediated Insulin Suppression in Hyperinsulinemic Obese Men, Part III[NCT00631033] | Phase 2 | 51 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 trials available for diazoxide and Weight Loss
Article | Year |
---|---|
High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention.
Topics: Adult; Blood Glucose; Body Mass Index; Body Weight; Diazoxide; Dose-Response Relationship, Drug; Dou | 2018 |
No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet.
Topics: Adult; Blood Glucose; C-Peptide; Counseling; Diazoxide; Diet, Reducing; Double-Blind Method; Energy | 2007 |
Beneficial effect of diazoxide in obese hyperinsulinemic adults.
Topics: Adult; Body Composition; Body Mass Index; Body Weight; Diazoxide; Diet, Reducing; Energy Intake; Fem | 1998 |
1 other study available for diazoxide and Weight Loss
Article | Year |
---|---|
Weight loss in obese men by caloric restriction and high-dose diazoxide-mediated insulin suppression.
Topics: Adult; Body Composition; Caloric Restriction; Diazoxide; Diet, Reducing; Dose-Response Relationship, | 2008 |