diazoxide has been researched along with Weight Loss in 4 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Weight Loss: Decrease in existing BODY WEIGHT.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men." | 9.27 | High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018) |
| " The aim of the present study was to investigate the effect of inhibition of insulin secretion by diazoxide on weight loss in obese, normoglycaemic (fasting plasma glucose of > or =6." | 9.12 | No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet. ( Astrup, A; Due, A; Eriksen, G; Flint, A; Hansen, JB; Møller, B; Raben, A, 2007) |
| "To examine the concept whether high-dose diazoxide (DZX)-mediated insulin suppression, in combination with moderate caloric restriction and increased physical activity, can establish a weight loss of at least 15% in obese hyperinsulinaemic men." | 7.74 | Weight loss in obese men by caloric restriction and high-dose diazoxide-mediated insulin suppression. ( de Boer, H; Loves, S; Rijnders, T; Ruinemans-Koerts, J; van Boekel, G; van Sorge, A, 2008) |
| "Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men." | 5.27 | High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018) |
| " The aim of the present study was to investigate the effect of inhibition of insulin secretion by diazoxide on weight loss in obese, normoglycaemic (fasting plasma glucose of > or =6." | 5.12 | No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet. ( Astrup, A; Due, A; Eriksen, G; Flint, A; Hansen, JB; Møller, B; Raben, A, 2007) |
| "To examine the concept whether high-dose diazoxide (DZX)-mediated insulin suppression, in combination with moderate caloric restriction and increased physical activity, can establish a weight loss of at least 15% in obese hyperinsulinaemic men." | 3.74 | Weight loss in obese men by caloric restriction and high-dose diazoxide-mediated insulin suppression. ( de Boer, H; Loves, S; Rijnders, T; Ruinemans-Koerts, J; van Boekel, G; van Sorge, A, 2008) |
| "The role of hyperinsulinemia as a possible preceding event in the development of obesity has been proposed." | 2.69 | Beneficial effect of diazoxide in obese hyperinsulinemic adults. ( Alemzadeh, R; Langley, G; Slonim, AE; Smith, P; Upchurch, L, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loves, S | 2 |
| van Groningen, L | 1 |
| Filius, M | 1 |
| Mekking, M | 1 |
| Brandon, T | 1 |
| Tack, CJ | 1 |
| Hermus, A | 1 |
| de Boer, H | 2 |
| Due, A | 1 |
| Flint, A | 1 |
| Eriksen, G | 1 |
| Møller, B | 1 |
| Raben, A | 1 |
| Hansen, JB | 1 |
| Astrup, A | 1 |
| van Boekel, G | 1 |
| van Sorge, A | 1 |
| Ruinemans-Koerts, J | 1 |
| Rijnders, T | 1 |
| Alemzadeh, R | 1 |
| Langley, G | 1 |
| Upchurch, L | 1 |
| Smith, P | 1 |
| Slonim, AE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diazoxide-mediated Insulin Suppression in Hyperinsulinemic Obese Men, Part III[NCT00631033] | Phase 2 | 51 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for diazoxide and Weight Loss
| Article | Year |
|---|---|
High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention.
Topics: Adult; Blood Glucose; Body Mass Index; Body Weight; Diazoxide; Dose-Response Relationship, Drug; Dou | 2018 |
No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet.
Topics: Adult; Blood Glucose; C-Peptide; Counseling; Diazoxide; Diet, Reducing; Double-Blind Method; Energy | 2007 |
Beneficial effect of diazoxide in obese hyperinsulinemic adults.
Topics: Adult; Body Composition; Body Mass Index; Body Weight; Diazoxide; Diet, Reducing; Energy Intake; Fem | 1998 |
1 other study available for diazoxide and Weight Loss
| Article | Year |
|---|---|
Weight loss in obese men by caloric restriction and high-dose diazoxide-mediated insulin suppression.
Topics: Adult; Body Composition; Caloric Restriction; Diazoxide; Diet, Reducing; Dose-Response Relationship, | 2008 |