diazoxide has been researched along with Syndrome in 20 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Syndrome: A characteristic symptom complex.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This syndrome is caused by dominantly expressed mutations of the glutamate dehydrogenase gene (10q23." | 5.32 | [Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide]. ( Argente Oliver, J; Donoso, MA; Martos Moreno, G; Montero Luis, C; Muñoz Calvo, MT; Pozo Román, J; Rubio Cabezas, O, 2004) |
| " Persistent hyperinsulinism was only described in two siblings and responded to diazoxide treatment." | 5.12 | Expanding the spectrum of endocrinopathies identified in Schaaf-Yang syndrome - A case report and review of the literature. ( Cohen, M; Ekhilevitch, N; Habib, C; Halloun, R; Tiosano, D; Weiss, R, 2021) |
| "This syndrome is characterised by recurrent episodes of hypoglycaemia and elevated ammonia levels, which are potentially harmful to both the patient and a developing fetus." | 1.56 | Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome. ( Bazelmans, M; Benner, BJM; Huidekoper, H; Langendonk, J; Langeveld, M; Schoenmakers, S, 2020) |
| "Hypoglycemia has been documented due to growth hormone and cortisol deficiency." | 1.33 | Costello syndrome and hyperinsulinemic hypoglycemia. ( Al-Sharkawi, I; Alexander, S; Alkhayyat, H; Backer, KC; El-Sabban, F; Hussain, K; Ramadan, D, 2005) |
| "This syndrome is caused by dominantly expressed mutations of the glutamate dehydrogenase gene (10q23." | 1.32 | [Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide]. ( Argente Oliver, J; Donoso, MA; Martos Moreno, G; Montero Luis, C; Muñoz Calvo, MT; Pozo Román, J; Rubio Cabezas, O, 2004) |
| "The hypertensive encephalopathy is a syndrome consisting of a sudden elevation of arterial pressure usually preceded by severe headache and followed by convulsions, coma or a variety of transitory cerebral phenomena." | 1.26 | Management of hypertensive encephalopathy. ( Finnerty, FA, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benner, BJM | 1 |
| Bazelmans, M | 1 |
| Huidekoper, H | 1 |
| Langeveld, M | 1 |
| Langendonk, J | 1 |
| Schoenmakers, S | 1 |
| Kostopoulou, E | 1 |
| Dastamani, A | 1 |
| Güemes, M | 1 |
| Clement, E | 1 |
| Caiulo, S | 1 |
| Shanmugananda, P | 1 |
| Dattani, M | 1 |
| Gilbert, C | 1 |
| Hurst, JA | 1 |
| Shah, P | 1 |
| Halloun, R | 1 |
| Habib, C | 1 |
| Ekhilevitch, N | 1 |
| Weiss, R | 1 |
| Tiosano, D | 1 |
| Cohen, M | 2 |
| Church, D | 1 |
| Cardoso, L | 1 |
| Kay, RG | 1 |
| Williams, CL | 1 |
| Freudenthal, B | 1 |
| Clarke, C | 1 |
| Harris, J | 1 |
| Moorthy, M | 1 |
| Karra, E | 1 |
| Gribble, FM | 1 |
| Reimann, F | 1 |
| Burling, K | 1 |
| Williams, AJK | 1 |
| Munir, A | 1 |
| Jones, TH | 1 |
| Führer, D | 1 |
| Moeller, LC | 1 |
| Khoo, B | 1 |
| Halsall, D | 1 |
| Semple, RK | 1 |
| Martínez-Ortega, AJ | 1 |
| Mangas-Cruz, MA | 1 |
| Aliaga-Verdugo, A | 1 |
| Acosta-Delgado, D | 1 |
| Montero Luis, C | 1 |
| Pozo Román, J | 1 |
| Muñoz Calvo, MT | 1 |
| Martos Moreno, G | 1 |
| Donoso, MA | 1 |
| Rubio Cabezas, O | 1 |
| Argente Oliver, J | 1 |
| Alexander, S | 1 |
| Ramadan, D | 1 |
| Alkhayyat, H | 1 |
| Al-Sharkawi, I | 1 |
| Backer, KC | 1 |
| El-Sabban, F | 1 |
| Hussain, K | 1 |
| Won, JG | 1 |
| Tseng, HS | 1 |
| Yang, AH | 1 |
| Tang, KT | 1 |
| Jap, TS | 1 |
| Lee, CH | 1 |
| Lin, HD | 1 |
| Burcus, N | 1 |
| Pittenger, G | 1 |
| Vinik, A | 1 |
| Grossman, SH | 1 |
| Gunnells, JC | 1 |
| Ram, CV | 1 |
| Spranger, JW | 1 |
| Schinzel, A | 1 |
| Myers, T | 1 |
| Ryan, J | 1 |
| Giedion, A | 1 |
| Opitz, JM | 1 |
| Surwit, RS | 1 |
| Dixon, TM | 1 |
| Petro, AE | 1 |
| Daniel, KW | 1 |
| Collins, S | 1 |
| Konijnendijk, MA | 1 |
| Zandbergen, AA | 1 |
| Verheul, FE | 1 |
| Baggen, MG | 1 |
| Kelly, A | 1 |
| Ng, D | 1 |
| Ferry, RJ | 1 |
| Grimberg, A | 1 |
| Koo-McCoy, S | 1 |
| Thornton, PS | 1 |
| Stanley, CA | 1 |
| Finnerty, FA | 1 |
| Moncrieff, MW | 1 |
| Lacey, KA | 1 |
| Malleson, PN | 1 |
| Bjerke, HS | 1 |
| Kelly, RE | 1 |
| Geffner, ME | 1 |
| Fonkalsrud, EW | 1 |
| Leng, JJ | 1 |
| Greenblatt, RB | 1 |
| Ludwig, M | 1 |
| Wolfson, S | 1 |
| Rennert, O | 1 |
| Dutau, G | 1 |
| Gire, JL | 1 |
| Henry, M | 1 |
| Rochiccioli, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Vitamin E in Hyperinsulinism/Hyperammonemia Syndrome[NCT04984798] | Phase 2 | 0 participants (Actual) | Interventional | 2022-11-30 | Withdrawn (stopped due to No study activity took place. The IND was withdrawn with the FDA by the Sponsor Investigator because of insurmountable hurdles in moving proposed research forward) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for diazoxide and Syndrome
| Article | Year |
|---|---|
Syndromic Forms of Hyperinsulinaemic Hypoglycaemia-A 15-year follow-up Study.
Topics: Child; Congenital Hyperinsulinism; Diazoxide; Follow-Up Studies; Humans; Infant; Retrospective Studi | 2021 |
Expanding the spectrum of endocrinopathies identified in Schaaf-Yang syndrome - A case report and review of the literature.
Topics: Developmental Disabilities; Diazoxide; Female; Humans; Hyperinsulinism; Infant; Insulin; Mutation; P | 2021 |
Recognition and treatment of hypertensive emergencies.
Topics: Anticoagulants; Brain Diseases; Cerebrovascular Disorders; Coronary Disease; Diagnosis, Differential | 1981 |
Hypertensive emergencies: recognition and management.
Topics: Acute Disease; Aortic Aneurysm; Aortic Dissection; Brain Diseases; Cerebral Hemorrhage; Coronary Dis | 1982 |
16 other studies available for diazoxide and Syndrome
| Article | Year |
|---|---|
Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome.
Topics: Adult; Diazoxide; Diet, Carbohydrate Loading; Directive Counseling; Female; Humans; Hyperammonemia; | 2020 |
Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome.
Topics: Adult; Aged; Autoimmune Diseases; Biomarkers; Blood Glucose; C-Peptide; Chromatography, Gel; Congeni | 2018 |
[Hirata's disease: report of a case].
Topics: Aged, 80 and over; Asian People; Autoimmune Diseases; Diazoxide; Drug Substitution; Edema; HLA-D Ant | 2014 |
[Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide].
Topics: Diazoxide; Glutamate Dehydrogenase; Humans; Hyperammonemia; Hyperinsulinism; Infant; Male; Mutation; | 2004 |
Costello syndrome and hyperinsulinemic hypoglycemia.
Topics: Abnormalities, Multiple; Diazoxide; Fatal Outcome; Female; Humans; Hyperinsulinism; Hypoglycemia; In | 2005 |
Clinical features and morphological characterization of 10 patients with noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS).
Topics: Adult; Aged; Amyloid; Antigens, Neoplasm; Biomarkers; Biomarkers, Tumor; C-Peptide; Cell Proliferati | 2006 |
Cerebroarthrodigital syndrome: a newly recognized formal genesis syndrome in three patients with apparent arthromyodysplasia and sacral agenesis, brain malformation and digital hypoplasia.
Topics: Arthrogryposis; Bone Diseases, Developmental; Brain; Diazoxide; Ergotamine; Female; Humans; Hydrocep | 1980 |
Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes.
Topics: Adipocytes; Adipose Tissue; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diazoxide; Diet; | 2000 |
Insulin autoimmune syndrome: the second Dutch case.
Topics: Aged; Aged, 80 and over; Autoimmune Diseases; Blood Glucose; Diazoxide; Follow-Up Studies; Humans; H | 2001 |
Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome.
Topics: Adolescent; Adult; Amino Acid Substitution; Ammonia; Blood Glucose; Child; Child, Preschool; Diazoxi | 2001 |
Management of hypertensive encephalopathy.
Topics: Brain Diseases; Cerebrovascular Disorders; Diagnosis, Differential; Diazoxide; Humans; Hypertension; | 1978 |
Management of prolonged hypoglycaemia in Beckwith's syndrome.
Topics: Abnormalities, Multiple; Adrenal Cortex Hormones; Diazoxide; Hernia, Umbilical; Humans; Hypoglycemia | 1977 |
Surgical management of islet cell dysmaturation syndrome in young children.
Topics: Adenoma; Combined Modality Therapy; Diazoxide; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; I | 1990 |
Hirsutism in adolescent girls.
Topics: Adolescent; Adrenocortical Hyperfunction; Cobalt; Cortisone; Cushing Syndrome; Dexamethasone; Diazox | 1972 |
Glycogen storage disease, type 8.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Blood Glucose; Diazoxide; F | 1972 |
[Wiedemann-Beckwith syndrome. Clinical and metabolic study of 4 cases].
Topics: Abnormalities, Multiple; Child, Preschool; Diazoxide; Hernia, Umbilical; Humans; Hypoglycemia; Male; | 1974 |