Page last updated: 2024-10-25

diazoxide and Syndrome

diazoxide has been researched along with Syndrome in 20 studies

Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.

Syndrome: A characteristic symptom complex.

Research Excerpts

ExcerptRelevanceReference
"This syndrome is caused by dominantly expressed mutations of the glutamate dehydrogenase gene (10q23."5.32[Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide]. ( Argente Oliver, J; Donoso, MA; Martos Moreno, G; Montero Luis, C; Muñoz Calvo, MT; Pozo Román, J; Rubio Cabezas, O, 2004)
" Persistent hyperinsulinism was only described in two siblings and responded to diazoxide treatment."5.12Expanding the spectrum of endocrinopathies identified in Schaaf-Yang syndrome - A case report and review of the literature. ( Cohen, M; Ekhilevitch, N; Habib, C; Halloun, R; Tiosano, D; Weiss, R, 2021)
"This syndrome is characterised by recurrent episodes of hypoglycaemia and elevated ammonia levels, which are potentially harmful to both the patient and a developing fetus."1.56Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome. ( Bazelmans, M; Benner, BJM; Huidekoper, H; Langendonk, J; Langeveld, M; Schoenmakers, S, 2020)
"Hypoglycemia has been documented due to growth hormone and cortisol deficiency."1.33Costello syndrome and hyperinsulinemic hypoglycemia. ( Al-Sharkawi, I; Alexander, S; Alkhayyat, H; Backer, KC; El-Sabban, F; Hussain, K; Ramadan, D, 2005)
"This syndrome is caused by dominantly expressed mutations of the glutamate dehydrogenase gene (10q23."1.32[Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide]. ( Argente Oliver, J; Donoso, MA; Martos Moreno, G; Montero Luis, C; Muñoz Calvo, MT; Pozo Román, J; Rubio Cabezas, O, 2004)
"The hypertensive encephalopathy is a syndrome consisting of a sudden elevation of arterial pressure usually preceded by severe headache and followed by convulsions, coma or a variety of transitory cerebral phenomena."1.26Management of hypertensive encephalopathy. ( Finnerty, FA, 1978)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19908 (40.00)18.7374
1990's1 (5.00)18.2507
2000's6 (30.00)29.6817
2010's2 (10.00)24.3611
2020's3 (15.00)2.80

Authors

AuthorsStudies
Benner, BJM1
Bazelmans, M1
Huidekoper, H1
Langeveld, M1
Langendonk, J1
Schoenmakers, S1
Kostopoulou, E1
Dastamani, A1
Güemes, M1
Clement, E1
Caiulo, S1
Shanmugananda, P1
Dattani, M1
Gilbert, C1
Hurst, JA1
Shah, P1
Halloun, R1
Habib, C1
Ekhilevitch, N1
Weiss, R1
Tiosano, D1
Cohen, M2
Church, D1
Cardoso, L1
Kay, RG1
Williams, CL1
Freudenthal, B1
Clarke, C1
Harris, J1
Moorthy, M1
Karra, E1
Gribble, FM1
Reimann, F1
Burling, K1
Williams, AJK1
Munir, A1
Jones, TH1
Führer, D1
Moeller, LC1
Khoo, B1
Halsall, D1
Semple, RK1
Martínez-Ortega, AJ1
Mangas-Cruz, MA1
Aliaga-Verdugo, A1
Acosta-Delgado, D1
Montero Luis, C1
Pozo Román, J1
Muñoz Calvo, MT1
Martos Moreno, G1
Donoso, MA1
Rubio Cabezas, O1
Argente Oliver, J1
Alexander, S1
Ramadan, D1
Alkhayyat, H1
Al-Sharkawi, I1
Backer, KC1
El-Sabban, F1
Hussain, K1
Won, JG1
Tseng, HS1
Yang, AH1
Tang, KT1
Jap, TS1
Lee, CH1
Lin, HD1
Burcus, N1
Pittenger, G1
Vinik, A1
Grossman, SH1
Gunnells, JC1
Ram, CV1
Spranger, JW1
Schinzel, A1
Myers, T1
Ryan, J1
Giedion, A1
Opitz, JM1
Surwit, RS1
Dixon, TM1
Petro, AE1
Daniel, KW1
Collins, S1
Konijnendijk, MA1
Zandbergen, AA1
Verheul, FE1
Baggen, MG1
Kelly, A1
Ng, D1
Ferry, RJ1
Grimberg, A1
Koo-McCoy, S1
Thornton, PS1
Stanley, CA1
Finnerty, FA1
Moncrieff, MW1
Lacey, KA1
Malleson, PN1
Bjerke, HS1
Kelly, RE1
Geffner, ME1
Fonkalsrud, EW1
Leng, JJ1
Greenblatt, RB1
Ludwig, M1
Wolfson, S1
Rennert, O1
Dutau, G1
Gire, JL1
Henry, M1
Rochiccioli, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Vitamin E in Hyperinsulinism/Hyperammonemia Syndrome[NCT04984798]Phase 20 participants (Actual)Interventional2022-11-30Withdrawn (stopped due to No study activity took place. The IND was withdrawn with the FDA by the Sponsor Investigator because of insurmountable hurdles in moving proposed research forward)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for diazoxide and Syndrome

ArticleYear
Syndromic Forms of Hyperinsulinaemic Hypoglycaemia-A 15-year follow-up Study.
    Clinical endocrinology, 2021, Volume: 94, Issue:3

    Topics: Child; Congenital Hyperinsulinism; Diazoxide; Follow-Up Studies; Humans; Infant; Retrospective Studi

2021
Expanding the spectrum of endocrinopathies identified in Schaaf-Yang syndrome - A case report and review of the literature.
    European journal of medical genetics, 2021, Volume: 64, Issue:8

    Topics: Developmental Disabilities; Diazoxide; Female; Humans; Hyperinsulinism; Infant; Insulin; Mutation; P

2021
Recognition and treatment of hypertensive emergencies.
    Cardiovascular clinics, 1981, Volume: 11, Issue:3

    Topics: Anticoagulants; Brain Diseases; Cerebrovascular Disorders; Coronary Disease; Diagnosis, Differential

1981
Hypertensive emergencies: recognition and management.
    Current problems in cardiology, 1982, Volume: 7, Issue:1

    Topics: Acute Disease; Aortic Aneurysm; Aortic Dissection; Brain Diseases; Cerebral Hemorrhage; Coronary Dis

1982

Other Studies

16 other studies available for diazoxide and Syndrome

ArticleYear
Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome.
    BMJ case reports, 2020, Aug-03, Volume: 13, Issue:8

    Topics: Adult; Diazoxide; Diet, Carbohydrate Loading; Directive Counseling; Female; Humans; Hyperammonemia;

2020
Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome.
    The Journal of clinical endocrinology and metabolism, 2018, 10-01, Volume: 103, Issue:10

    Topics: Adult; Aged; Autoimmune Diseases; Biomarkers; Blood Glucose; C-Peptide; Chromatography, Gel; Congeni

2018
[Hirata's disease: report of a case].
    Medicina clinica, 2014, Feb-20, Volume: 142, Issue:4

    Topics: Aged, 80 and over; Asian People; Autoimmune Diseases; Diazoxide; Drug Substitution; Edema; HLA-D Ant

2014
[Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide].
    Anales de pediatria (Barcelona, Spain : 2003), 2004, Volume: 61, Issue:5

    Topics: Diazoxide; Glutamate Dehydrogenase; Humans; Hyperammonemia; Hyperinsulinism; Infant; Male; Mutation;

2004
Costello syndrome and hyperinsulinemic hypoglycemia.
    American journal of medical genetics. Part A, 2005, Dec-15, Volume: 139, Issue:3

    Topics: Abnormalities, Multiple; Diazoxide; Fatal Outcome; Female; Humans; Hyperinsulinism; Hypoglycemia; In

2005
Clinical features and morphological characterization of 10 patients with noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS).
    Clinical endocrinology, 2006, Volume: 65, Issue:5

    Topics: Adult; Aged; Amyloid; Antigens, Neoplasm; Biomarkers; Biomarkers, Tumor; C-Peptide; Cell Proliferati

2006
Cerebroarthrodigital syndrome: a newly recognized formal genesis syndrome in three patients with apparent arthromyodysplasia and sacral agenesis, brain malformation and digital hypoplasia.
    American journal of medical genetics, 1980, Volume: 5, Issue:1

    Topics: Arthrogryposis; Bone Diseases, Developmental; Brain; Diazoxide; Ergotamine; Female; Humans; Hydrocep

1980
Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adipocytes; Adipose Tissue; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diazoxide; Diet;

2000
Insulin autoimmune syndrome: the second Dutch case.
    The Netherlands journal of medicine, 2001, Volume: 58, Issue:1

    Topics: Aged; Aged, 80 and over; Autoimmune Diseases; Blood Glucose; Diazoxide; Follow-Up Studies; Humans; H

2001
Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:8

    Topics: Adolescent; Adult; Amino Acid Substitution; Ammonia; Blood Glucose; Child; Child, Preschool; Diazoxi

2001
Management of hypertensive encephalopathy.
    Herz, 1978, Volume: 3, Issue:5

    Topics: Brain Diseases; Cerebrovascular Disorders; Diagnosis, Differential; Diazoxide; Humans; Hypertension;

1978
Management of prolonged hypoglycaemia in Beckwith's syndrome.
    Postgraduate medical journal, 1977, Volume: 53, Issue:617

    Topics: Abnormalities, Multiple; Adrenal Cortex Hormones; Diazoxide; Hernia, Umbilical; Humans; Hypoglycemia

1977
Surgical management of islet cell dysmaturation syndrome in young children.
    Surgery, gynecology & obstetrics, 1990, Volume: 171, Issue:4

    Topics: Adenoma; Combined Modality Therapy; Diazoxide; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; I

1990
Hirsutism in adolescent girls.
    Pediatric clinics of North America, 1972, Volume: 19, Issue:3

    Topics: Adolescent; Adrenocortical Hyperfunction; Cobalt; Cortisone; Cushing Syndrome; Dexamethasone; Diazox

1972
Glycogen storage disease, type 8.
    Archives of disease in childhood, 1972, Volume: 47, Issue:255

    Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Blood Glucose; Diazoxide; F

1972
[Wiedemann-Beckwith syndrome. Clinical and metabolic study of 4 cases].
    Pediatrie, 1974, Volume: 29, Issue:2

    Topics: Abnormalities, Multiple; Child, Preschool; Diazoxide; Hernia, Umbilical; Humans; Hypoglycemia; Male;

1974