diazoxide has been researched along with Syndrome in 20 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Syndrome: A characteristic symptom complex.
Excerpt | Relevance | Reference |
---|---|---|
"This syndrome is caused by dominantly expressed mutations of the glutamate dehydrogenase gene (10q23." | 5.32 | [Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide]. ( Argente Oliver, J; Donoso, MA; Martos Moreno, G; Montero Luis, C; Muñoz Calvo, MT; Pozo Román, J; Rubio Cabezas, O, 2004) |
" Persistent hyperinsulinism was only described in two siblings and responded to diazoxide treatment." | 5.12 | Expanding the spectrum of endocrinopathies identified in Schaaf-Yang syndrome - A case report and review of the literature. ( Cohen, M; Ekhilevitch, N; Habib, C; Halloun, R; Tiosano, D; Weiss, R, 2021) |
"This syndrome is characterised by recurrent episodes of hypoglycaemia and elevated ammonia levels, which are potentially harmful to both the patient and a developing fetus." | 1.56 | Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome. ( Bazelmans, M; Benner, BJM; Huidekoper, H; Langendonk, J; Langeveld, M; Schoenmakers, S, 2020) |
"Hypoglycemia has been documented due to growth hormone and cortisol deficiency." | 1.33 | Costello syndrome and hyperinsulinemic hypoglycemia. ( Al-Sharkawi, I; Alexander, S; Alkhayyat, H; Backer, KC; El-Sabban, F; Hussain, K; Ramadan, D, 2005) |
"This syndrome is caused by dominantly expressed mutations of the glutamate dehydrogenase gene (10q23." | 1.32 | [Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide]. ( Argente Oliver, J; Donoso, MA; Martos Moreno, G; Montero Luis, C; Muñoz Calvo, MT; Pozo Román, J; Rubio Cabezas, O, 2004) |
"The hypertensive encephalopathy is a syndrome consisting of a sudden elevation of arterial pressure usually preceded by severe headache and followed by convulsions, coma or a variety of transitory cerebral phenomena." | 1.26 | Management of hypertensive encephalopathy. ( Finnerty, FA, 1978) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (40.00) | 18.7374 |
1990's | 1 (5.00) | 18.2507 |
2000's | 6 (30.00) | 29.6817 |
2010's | 2 (10.00) | 24.3611 |
2020's | 3 (15.00) | 2.80 |
Authors | Studies |
---|---|
Benner, BJM | 1 |
Bazelmans, M | 1 |
Huidekoper, H | 1 |
Langeveld, M | 1 |
Langendonk, J | 1 |
Schoenmakers, S | 1 |
Kostopoulou, E | 1 |
Dastamani, A | 1 |
Güemes, M | 1 |
Clement, E | 1 |
Caiulo, S | 1 |
Shanmugananda, P | 1 |
Dattani, M | 1 |
Gilbert, C | 1 |
Hurst, JA | 1 |
Shah, P | 1 |
Halloun, R | 1 |
Habib, C | 1 |
Ekhilevitch, N | 1 |
Weiss, R | 1 |
Tiosano, D | 1 |
Cohen, M | 2 |
Church, D | 1 |
Cardoso, L | 1 |
Kay, RG | 1 |
Williams, CL | 1 |
Freudenthal, B | 1 |
Clarke, C | 1 |
Harris, J | 1 |
Moorthy, M | 1 |
Karra, E | 1 |
Gribble, FM | 1 |
Reimann, F | 1 |
Burling, K | 1 |
Williams, AJK | 1 |
Munir, A | 1 |
Jones, TH | 1 |
Führer, D | 1 |
Moeller, LC | 1 |
Khoo, B | 1 |
Halsall, D | 1 |
Semple, RK | 1 |
Martínez-Ortega, AJ | 1 |
Mangas-Cruz, MA | 1 |
Aliaga-Verdugo, A | 1 |
Acosta-Delgado, D | 1 |
Montero Luis, C | 1 |
Pozo Román, J | 1 |
Muñoz Calvo, MT | 1 |
Martos Moreno, G | 1 |
Donoso, MA | 1 |
Rubio Cabezas, O | 1 |
Argente Oliver, J | 1 |
Alexander, S | 1 |
Ramadan, D | 1 |
Alkhayyat, H | 1 |
Al-Sharkawi, I | 1 |
Backer, KC | 1 |
El-Sabban, F | 1 |
Hussain, K | 1 |
Won, JG | 1 |
Tseng, HS | 1 |
Yang, AH | 1 |
Tang, KT | 1 |
Jap, TS | 1 |
Lee, CH | 1 |
Lin, HD | 1 |
Burcus, N | 1 |
Pittenger, G | 1 |
Vinik, A | 1 |
Grossman, SH | 1 |
Gunnells, JC | 1 |
Ram, CV | 1 |
Spranger, JW | 1 |
Schinzel, A | 1 |
Myers, T | 1 |
Ryan, J | 1 |
Giedion, A | 1 |
Opitz, JM | 1 |
Surwit, RS | 1 |
Dixon, TM | 1 |
Petro, AE | 1 |
Daniel, KW | 1 |
Collins, S | 1 |
Konijnendijk, MA | 1 |
Zandbergen, AA | 1 |
Verheul, FE | 1 |
Baggen, MG | 1 |
Kelly, A | 1 |
Ng, D | 1 |
Ferry, RJ | 1 |
Grimberg, A | 1 |
Koo-McCoy, S | 1 |
Thornton, PS | 1 |
Stanley, CA | 1 |
Finnerty, FA | 1 |
Moncrieff, MW | 1 |
Lacey, KA | 1 |
Malleson, PN | 1 |
Bjerke, HS | 1 |
Kelly, RE | 1 |
Geffner, ME | 1 |
Fonkalsrud, EW | 1 |
Leng, JJ | 1 |
Greenblatt, RB | 1 |
Ludwig, M | 1 |
Wolfson, S | 1 |
Rennert, O | 1 |
Dutau, G | 1 |
Gire, JL | 1 |
Henry, M | 1 |
Rochiccioli, P | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Efficacy of Vitamin E in Hyperinsulinism/Hyperammonemia Syndrome[NCT04984798] | Phase 2 | 0 participants (Actual) | Interventional | 2022-11-30 | Withdrawn (stopped due to No study activity took place. The IND was withdrawn with the FDA by the Sponsor Investigator because of insurmountable hurdles in moving proposed research forward) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
4 reviews available for diazoxide and Syndrome
Article | Year |
---|---|
Syndromic Forms of Hyperinsulinaemic Hypoglycaemia-A 15-year follow-up Study.
Topics: Child; Congenital Hyperinsulinism; Diazoxide; Follow-Up Studies; Humans; Infant; Retrospective Studi | 2021 |
Expanding the spectrum of endocrinopathies identified in Schaaf-Yang syndrome - A case report and review of the literature.
Topics: Developmental Disabilities; Diazoxide; Female; Humans; Hyperinsulinism; Infant; Insulin; Mutation; P | 2021 |
Recognition and treatment of hypertensive emergencies.
Topics: Anticoagulants; Brain Diseases; Cerebrovascular Disorders; Coronary Disease; Diagnosis, Differential | 1981 |
Hypertensive emergencies: recognition and management.
Topics: Acute Disease; Aortic Aneurysm; Aortic Dissection; Brain Diseases; Cerebral Hemorrhage; Coronary Dis | 1982 |
16 other studies available for diazoxide and Syndrome
Article | Year |
---|---|
Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome.
Topics: Adult; Diazoxide; Diet, Carbohydrate Loading; Directive Counseling; Female; Humans; Hyperammonemia; | 2020 |
Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome.
Topics: Adult; Aged; Autoimmune Diseases; Biomarkers; Blood Glucose; C-Peptide; Chromatography, Gel; Congeni | 2018 |
[Hirata's disease: report of a case].
Topics: Aged, 80 and over; Asian People; Autoimmune Diseases; Diazoxide; Drug Substitution; Edema; HLA-D Ant | 2014 |
[Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide].
Topics: Diazoxide; Glutamate Dehydrogenase; Humans; Hyperammonemia; Hyperinsulinism; Infant; Male; Mutation; | 2004 |
Costello syndrome and hyperinsulinemic hypoglycemia.
Topics: Abnormalities, Multiple; Diazoxide; Fatal Outcome; Female; Humans; Hyperinsulinism; Hypoglycemia; In | 2005 |
Clinical features and morphological characterization of 10 patients with noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS).
Topics: Adult; Aged; Amyloid; Antigens, Neoplasm; Biomarkers; Biomarkers, Tumor; C-Peptide; Cell Proliferati | 2006 |
Cerebroarthrodigital syndrome: a newly recognized formal genesis syndrome in three patients with apparent arthromyodysplasia and sacral agenesis, brain malformation and digital hypoplasia.
Topics: Arthrogryposis; Bone Diseases, Developmental; Brain; Diazoxide; Ergotamine; Female; Humans; Hydrocep | 1980 |
Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes.
Topics: Adipocytes; Adipose Tissue; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diazoxide; Diet; | 2000 |
Insulin autoimmune syndrome: the second Dutch case.
Topics: Aged; Aged, 80 and over; Autoimmune Diseases; Blood Glucose; Diazoxide; Follow-Up Studies; Humans; H | 2001 |
Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome.
Topics: Adolescent; Adult; Amino Acid Substitution; Ammonia; Blood Glucose; Child; Child, Preschool; Diazoxi | 2001 |
Management of hypertensive encephalopathy.
Topics: Brain Diseases; Cerebrovascular Disorders; Diagnosis, Differential; Diazoxide; Humans; Hypertension; | 1978 |
Management of prolonged hypoglycaemia in Beckwith's syndrome.
Topics: Abnormalities, Multiple; Adrenal Cortex Hormones; Diazoxide; Hernia, Umbilical; Humans; Hypoglycemia | 1977 |
Surgical management of islet cell dysmaturation syndrome in young children.
Topics: Adenoma; Combined Modality Therapy; Diazoxide; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; I | 1990 |
Hirsutism in adolescent girls.
Topics: Adolescent; Adrenocortical Hyperfunction; Cobalt; Cortisone; Cushing Syndrome; Dexamethasone; Diazox | 1972 |
Glycogen storage disease, type 8.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Blood Glucose; Diazoxide; F | 1972 |
[Wiedemann-Beckwith syndrome. Clinical and metabolic study of 4 cases].
Topics: Abnormalities, Multiple; Child, Preschool; Diazoxide; Hernia, Umbilical; Humans; Hypoglycemia; Male; | 1974 |