diazoxide has been researched along with Seizures in 24 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, the mechanism of DZ protecting hippocampal neurons against cell death in pilocarpine-induced seizures is unknown." | 7.77 | Role of PI3K/Akt in diazoxide preconditioning against rat hippocampal neuronal death in pilocarpine-induced seizures. ( Chi, Z; Han, Y; Jiang, H; Lin, Y; Wang, S; Xie, N; Xu, J; Xue, Y, 2011) |
| "Our data revealed that seizure threshold was increased 6 to 72 hours after nasal obstruction, reaching a peak 48 hours afterward, compared with either control or sham-operated mice (P<0." | 5.35 | Mouth breathing increases the pentylenetetrazole-induced seizure threshold in mice: a role for ATP-sensitive potassium channels. ( Dehpour, AR; Fakhimi, A; Ghasemi, M; Niaki, SE; Shafaroodi, H; Shakiba, B, 2008) |
| " Here we present a case of sever congenital hyperinsulinism in a girl admitted for lethargy, irritability and general seizures accompanied with profound hypoglycemia, in spite of aggressive medical treatment, she died because of sever congenital hyperinsulinism diazoxide unresponsive." | 5.05 | Congenital hyperinsulinsim: case report and review of literature. ( Abilkassem, R; Agadr, A; Elyajouri, A; Hasbaoui, BE, 2020) |
| " This study was conducted to investigate whether or not triamterene, a K(+)-sparing diuretic, can generate protection against seizures induced by intravenous or intraperitoneal pentylenetetrazole (PTZ) models." | 3.83 | A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice. ( Almasirad, A; Barati, S; Ghasemi, M; Moezi, L; Shafaroodi, H, 2016) |
| " However, the mechanism of DZ protecting hippocampal neurons against cell death in pilocarpine-induced seizures is unknown." | 3.77 | Role of PI3K/Akt in diazoxide preconditioning against rat hippocampal neuronal death in pilocarpine-induced seizures. ( Chi, Z; Han, Y; Jiang, H; Lin, Y; Wang, S; Xie, N; Xu, J; Xue, Y, 2011) |
| " In this study, we investigated DZ attenuating neuronal loss caused by pilocarpine-induced seizures in rat hippocampus." | 3.77 | Diazoxide preconditioning against seizure-induced oxidative injury is via the PI3K/Akt pathway in epileptic rat. ( Cao, L; Chi, Z; Jiang, H; Xie, N; Xue, Y; Zhao, X, 2011) |
| "Hyperinsulinemic hypoglycemia secondary to nesidioblastosis persisted in a 4-year-old girl despite a 95% pancreatectomy and high-dose diazoxide treatment." | 3.66 | Persistent leucine sensitivity following partial pancreatectomy and diazoxide treatment. Therapeutic response. ( Bradvica, C; Golden, MP; Graham, MJ; Santiago, J; Sargeant, DT; White, NH; Zuniga, O, 1983) |
| "In two children treated for hypoglycemia and convulsions with diazoxide and diphenylhydantoin, therapeutic serum diphenylhydantoin levels were not achieved despite doses of diphenylhydantoin of 17 and 29 mg/kg/day, respectively." | 3.65 | Drug interaction: diazoxide and diphenylhydantoin. ( Blaskovics, ME; Podosin, RL; Roe, TF, 1975) |
| "Our data revealed that seizure threshold was increased 6 to 72 hours after nasal obstruction, reaching a peak 48 hours afterward, compared with either control or sham-operated mice (P<0." | 1.35 | Mouth breathing increases the pentylenetetrazole-induced seizure threshold in mice: a role for ATP-sensitive potassium channels. ( Dehpour, AR; Fakhimi, A; Ghasemi, M; Niaki, SE; Shafaroodi, H; Shakiba, B, 2008) |
| "The third has occasional fasting hypoglycemia that is treated with diazoxide; he continues to have a seizure disorder and is mentally retarded." | 1.26 | Nesidioblastosis in children. ( Danis, RK; Garvin, PJ; Knight, J; Lewis, JE; Willman, VL, 1980) |
| "A seven months old infant suffered from convulsions due to leucine-sensitive hypoglycaemia." | 1.26 | [Leucine-sensitive hypoglycaemia and its treatment with diazoxide (author's transl)]. ( Reich, H; Schünke, W, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (58.33) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 5 (20.83) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Logel, SN | 1 |
| Connor, EL | 1 |
| Hsu, DA | 1 |
| Fenske, RJ | 1 |
| Paloian, NJ | 1 |
| De Vivo, DC | 1 |
| Hasbaoui, BE | 1 |
| Elyajouri, A | 1 |
| Abilkassem, R | 1 |
| Agadr, A | 1 |
| Jazayeri, A | 1 |
| Zolfaghari, S | 1 |
| Ostadhadi, S | 1 |
| Shafaroodi, H | 2 |
| Barati, S | 1 |
| Ghasemi, M | 2 |
| Almasirad, A | 1 |
| Moezi, L | 1 |
| Niaki, SE | 1 |
| Shakiba, B | 1 |
| Fakhimi, A | 1 |
| Dehpour, AR | 1 |
| Narayanaswamy, V | 1 |
| Rettig, KR | 1 |
| Bhowmick, SK | 1 |
| Xue, Y | 2 |
| Xie, N | 2 |
| Lin, Y | 1 |
| Xu, J | 1 |
| Han, Y | 1 |
| Wang, S | 1 |
| Jiang, H | 2 |
| Chi, Z | 2 |
| Cao, L | 1 |
| Zhao, X | 1 |
| Gonc, EN | 1 |
| Turul, T | 1 |
| Yordam, N | 1 |
| Ersoy, F | 1 |
| Knight, J | 1 |
| Garvin, PJ | 1 |
| Danis, RK | 1 |
| Lewis, JE | 1 |
| Willman, VL | 1 |
| Zuniga, O | 1 |
| Golden, MP | 1 |
| Sargeant, DT | 1 |
| Graham, MJ | 1 |
| Bradvica, C | 1 |
| Santiago, J | 1 |
| White, NH | 1 |
| Gantenbein, M | 1 |
| Attolini, L | 1 |
| Bruguerolle, B | 1 |
| Gardoni, L | 1 |
| Giranzani, F | 1 |
| Duvina, PL | 1 |
| Reich, H | 1 |
| Schünke, W | 1 |
| Roe, TF | 1 |
| Podosin, RL | 1 |
| Blaskovics, ME | 1 |
| Callanan, DL | 1 |
| Cheng, R | 1 |
| Brown, LW | 1 |
| Etheridge, JE | 1 |
| Hansson, O | 1 |
| Tuvemo, T | 1 |
| Westphal, O | 1 |
| Yoshinaga, T | 1 |
| Isshiki, G | 1 |
| Okuno, G | 1 |
| Ueda, T | 1 |
| Ogawa, S | 1 |
| Finnerty, FA | 1 |
| Bergmann, F | 1 |
| Zerachia, A | 1 |
| Chaimovitz, M | 1 |
| Gutman, Y | 1 |
| Koblenzer, PJ | 1 |
| Baker, L | 1 |
2 reviews available for diazoxide and Seizures
| Article | Year |
|---|---|
Congenital hyperinsulinsim: case report and review of literature.
Topics: Congenital Hyperinsulinism; Diazoxide; Fatal Outcome; Female; Humans; Infant, Newborn; Seizures; Sev | 2020 |
Hypoglycemia and the central nervous system.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Child, Preschool; Diazoxide; Diet Therapy; Epin | 1967 |
22 other studies available for diazoxide and Seizures
| Article | Year |
|---|---|
Exploring diazoxide and continuous glucose monitoring as treatment for Glut1 deficiency syndrome.
Topics: Adolescent; Blood Glucose Self-Monitoring; Carbohydrate Metabolism, Inborn Errors; Diazoxide; Female | 2021 |
Anticonvulsant effect of Diazoxide against Dichlorvos-induced seizures in mice.
Topics: Animals; Anticonvulsants; Antihypertensive Agents; Diazoxide; Dichlorvos; Dose-Response Relationship | 2013 |
A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Convulsants; Diazoxide; Disease Models, Animal; Dose | 2016 |
Mouth breathing increases the pentylenetetrazole-induced seizure threshold in mice: a role for ATP-sensitive potassium channels.
Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Animals; Brain; Carbon Dioxide; Diazoxide; Dose-Respon | 2008 |
A lethargic neonate and an infant with seizure.
Topics: Blood Glucose; Congenital Hyperinsulinism; Diazoxide; Glucagon; Glucose; Humans; Hypoglycemia; Infan | 2010 |
Role of PI3K/Akt in diazoxide preconditioning against rat hippocampal neuronal death in pilocarpine-induced seizures.
Topics: Animals; Blotting, Western; Cell Death; Convulsants; Diazoxide; Hippocampus; Neurons; Neuroprotectiv | 2011 |
Diazoxide preconditioning against seizure-induced oxidative injury is via the PI3K/Akt pathway in epileptic rat.
Topics: Androstadienes; Animals; Decanoic Acids; Diazoxide; Epilepsy; Hydroxy Acids; Male; Malondialdehyde; | 2011 |
Trimethoprim-sulfamethoxazole induced prolonged hypoglycemia in an infant with MHC class II deficiency: diazoxide as a treatment option.
Topics: Blood Glucose; C-Peptide; Diazoxide; Drug Administration Schedule; Female; Gene Expression; Genes, M | 2003 |
Nesidioblastosis in children.
Topics: Adenoma, Islet Cell; Child, Preschool; Diazoxide; Female; Glucagon; Glucose; Humans; Hyperinsulinism | 1980 |
Persistent leucine sensitivity following partial pancreatectomy and diazoxide treatment. Therapeutic response.
Topics: Child, Preschool; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Leucine; Pancreatectomy; | 1983 |
Preeclampsia and eclampsia.
Topics: Adult; Diazoxide; Eclampsia; Female; Humans; Hydralazine; Magnesium Sulfate; Pre-Eclampsia; Pregnanc | 1981 |
Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice.
Topics: Animals; Benzopyrans; Bupivacaine; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Guanidin | 1995 |
[Description of a case of type I glycogenosis treated with diazoxide].
Topics: Diazoxide; Glycogen Storage Disease Type I; Humans; Hypoglycemia; Infant; Liver; Male; Seizures | 1978 |
[9 years of diazoxide therapy in a case of infantile idiopathic hypolglycemia].
Topics: Child; Diazoxide; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Male; Prediabetic State; Se | 1978 |
[Leucine-sensitive hypoglycaemia and its treatment with diazoxide (author's transl)].
Topics: Amino Acid Metabolism, Inborn Errors; Blood Glucose; Diazoxide; Dietary Proteins; Female; Humans; Hy | 1976 |
Drug interaction: diazoxide and diphenylhydantoin.
Topics: Administration, Oral; Adolescent; Child, Preschool; Chromatography, Gas; Diazoxide; Drug Therapy, Co | 1975 |
Recurrent seizures in a 'well-controlled' child.
Topics: Antihypertensive Agents; Child, Preschool; Diazoxide; Drug Therapy, Combination; Hemolytic-Uremic Sy | 1986 |
[Diazoxide as therapy for idiopathic hypoglycemia in children (author's transl)].
Topics: Catecholamines; Child; Child, Preschool; Cyanosis; Diazoxide; Diet Therapy; Fasting; Female; Fever; | 1974 |
A-cell deficiency and B-cell hyperplasia of Langerhans' islet as a cause of leucine sensitive hypoglycemia.
Topics: Blood Glucose; Diazoxide; Epinephrine; Glucose Tolerance Test; Humans; Hyperplasia; Hypoglycemia; In | 1968 |
Hypertensive encephalopathy.
Topics: Anxiety; Brain Diseases; Brain Edema; Coma; Diazoxide; Female; Furosemide; Glomerulonephritis; Heada | 1972 |
Influence of drugs, implanted into the hypothalamus, on the water consumption of rats.
Topics: Animals; Behavior, Animal; Diazoxide; Digitoxin; Diuretics; Drinking; Ethacrynic Acid; Furosemide; H | 1968 |
Hypertichosis lanuginosa acquisita.
Topics: Diazoxide; Humans; Hypertrichosis; Hypoglycemia; Infant; Leucine; Male; Pancreatectomy; Seizures | 1969 |