diazoxide has been researched along with Reperfusion Injury in 40 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effect of MCU opener spermine on diazoxide against focal cerebral ischemia-reperfusion injury in rats." | 7.80 | The effect of mitochondrial calcium uniporter opener spermine on diazoxide against focal cerebral ischemia--reperfusion injury in rats. ( Dong, H; Liu, Z; Wang, S; Yu, A; Zhang, Z, 2014) |
| " We investigated the effects of mitoK(ATP) channel opener diazoxide on BBB functions during ischemia/reperfusion injury (I/R)." | 7.73 | Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability. ( Bari, F; Busija, DW; Kis, B; Lenzsér, G, 2005) |
| " The current study was designed to investigate the effects of diazoxide (DZ) on mitochondrial structure, neurological function, DNA damage-repair, and apoptosis in spinal cord ischemia-reperfusion injury." | 7.73 | The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord. ( Chen, L; Gao, D; Roseborough, G; Trush, MA; Wei, C; Williams, GM; Zhou, S, 2006) |
| "According to different treatment received before ischemic-reperfusion injury, 66 SD rats were divided into 6 groups including a normal control and a ischemia-reperfusion control group, IP10 group in which the rats received 10-min ischemia followed by 10-min interval for reperfusion for 3 times before IR, IP5 group in which the rats were subjected to 5-min ischemia with 5-min reperfusion intervals for 3 times before IR, adenosine (Ade) pretreatment group and diazoxide (Dia) pretreatment group." | 7.71 | Effect of pretreatment with adenosine, diazoxide or ischemic preconditioning on ischemia- reperfusion injury in the limbs of rats. ( Pei, GX; Wang, G; Wang, HM; Wang, QL, 2002) |
| "However, the effects of DZ in spinal cord ischemia-reperfusion injury have not been fully elucidated." | 5.51 | Pretreatment With Diazoxide Attenuates Spinal Cord Ischemia-Reperfusion Injury Through Signaling Transducer and Activator of Transcription 3 Pathway. ( Aftab, M; Cleveland, JC; Eldeiry, M; Fullerton, DA; Meng, X; Reece, TB; Roda, G; Ryan, TJ; Weyant, MJ; Yamanaka, K, 2019) |
| "Diazoxide (DZ) is a pharmacological opener of ATP-sensitive K(+) channels that has been used for mimicking ischemic preconditioning and shows protection against ischemic damage." | 5.42 | Diazoxide, a K(ATP) channel opener, prevents ischemia-reperfusion injury in rodent pancreatic islets. ( Feng, F; Harvat, T; Kinzer, K; Oberholzer, J; Qi, M; Wang, S; Wang, Y; Zhang, L, 2015) |
| "We investigated the effect of MCU opener spermine on diazoxide against focal cerebral ischemia-reperfusion injury in rats." | 3.80 | The effect of mitochondrial calcium uniporter opener spermine on diazoxide against focal cerebral ischemia--reperfusion injury in rats. ( Dong, H; Liu, Z; Wang, S; Yu, A; Zhang, Z, 2014) |
| "To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury." | 3.80 | Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury. ( Coelho, AM; D'Albuquerque, LA; Machado, MC; Nogueira, MA; Patzina, RA; Pinheiro da Silva, F; Sampietre, SN, 2014) |
| " We investigated the effects of mitoK(ATP) channel opener diazoxide on BBB functions during ischemia/reperfusion injury (I/R)." | 3.73 | Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability. ( Bari, F; Busija, DW; Kis, B; Lenzsér, G, 2005) |
| " The current study was designed to investigate the effects of diazoxide (DZ) on mitochondrial structure, neurological function, DNA damage-repair, and apoptosis in spinal cord ischemia-reperfusion injury." | 3.73 | The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord. ( Chen, L; Gao, D; Roseborough, G; Trush, MA; Wei, C; Williams, GM; Zhou, S, 2006) |
| " We examined KATP channel modulation in renal ischemia-reperfusion injury (IRI), using an isolated perfused rat kidney (IPRK) model, in control, IRI, IRI+200 microM diazoxide (a KATP opener), IRI + 10 microM glibenclamide (a KATP blocker) and IRI + 200 microM diazoxide + 10 microM glibenclamide groups." | 3.72 | ATP-dependent K+ channels in renal ischemia reperfusion injury. ( Endre, ZH; Gobé, GC; Rahgozar, M; Willgoss, DA, 2003) |
| "According to different treatment received before ischemic-reperfusion injury, 66 SD rats were divided into 6 groups including a normal control and a ischemia-reperfusion control group, IP10 group in which the rats received 10-min ischemia followed by 10-min interval for reperfusion for 3 times before IR, IP5 group in which the rats were subjected to 5-min ischemia with 5-min reperfusion intervals for 3 times before IR, adenosine (Ade) pretreatment group and diazoxide (Dia) pretreatment group." | 3.71 | Effect of pretreatment with adenosine, diazoxide or ischemic preconditioning on ischemia- reperfusion injury in the limbs of rats. ( Pei, GX; Wang, G; Wang, HM; Wang, QL, 2002) |
| "However, the effects of DZ in spinal cord ischemia-reperfusion injury have not been fully elucidated." | 1.51 | Pretreatment With Diazoxide Attenuates Spinal Cord Ischemia-Reperfusion Injury Through Signaling Transducer and Activator of Transcription 3 Pathway. ( Aftab, M; Cleveland, JC; Eldeiry, M; Fullerton, DA; Meng, X; Reece, TB; Roda, G; Ryan, TJ; Weyant, MJ; Yamanaka, K, 2019) |
| "Diazoxide (DZ) is a pharmacological opener of ATP-sensitive K(+) channels that has been used for mimicking ischemic preconditioning and shows protection against ischemic damage." | 1.42 | Diazoxide, a K(ATP) channel opener, prevents ischemia-reperfusion injury in rodent pancreatic islets. ( Feng, F; Harvat, T; Kinzer, K; Oberholzer, J; Qi, M; Wang, S; Wang, Y; Zhang, L, 2015) |
| "Diazoxide and spermine were administrated 30 minutes before ischemia or 10 minutes before reperfusion, respectively." | 1.40 | Spermine attenuates the preconditioning of diazoxide against transient focal cerebral ischemia in rats. ( Dong, H; Guo, Y; Li, S; Li, Y; Wang, P; Wang, S; Yao, R; Zhang, L, 2014) |
| "Pretreatment with diazoxide, K(ATP) channel opener, increases tissue tolerance against ischemia reperfusion (IR) injury." | 1.38 | Skeletal muscle post-conditioning by diazoxide, anti-oxidative and anti-apoptotic mechanisms. ( Ajami, M; Ebrahimi, SA; Habibey, R; Moghtadaei, M; Pazoki-Toroudi, H; Soleimani, M, 2012) |
| "Diazoxide treatment attenuated cytotoxicity in both cell types and 5-HD treatment-increased cytotoxicity in the sensitive NRK cells in a superoxide-dependant manner." | 1.36 | Variable effects of the mitoK(ATP) channel modulators diazoxide and 5-HD in ATP-depleted renal epithelial cells. ( Johnson, CP; Liang, H; Mortensen, J; Nilakantan, V; Taylor, E, 2010) |
| "Pretreatment with diazoxide, a mitochondrial ATP-sensitive potassium channel (mito KATP) opener, was found to protect the rat heart against ischaemia-reperfusion (I/R) injury by mimicking ischaemic preconditioning (IPC)." | 1.36 | Myocardial ischaemic and diazoxide preconditioning both increase PGC-1alpha and reduce mitochondrial damage. ( Han, HG; Han, JS; Li, XM; Wang, HS; Wang, ZW; Yan, DM; Zhu, HY, 2010) |
| "IPC or ischemia was induced in rat retina in vivo." | 1.35 | Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning. ( Barone, FC; Dreixler, JC; Du, E; Roth, S; Shaikh, AR, 2009) |
| "Propofol treatments were initiated at various time intervals: 1 or 24 h before ischemia, only during ischemia, or only during reperfusion." | 1.35 | The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion. ( Assad, AR; Capella, MA; Delou, JM; Fonseca, LM; Lopes, AG; Nascimento, JH; Verçosa, N; Villela, NR, 2009) |
| "Diazoxide is a selective mitochondria ATP-sensitive potassium (K(ATP)) channel opener, which has been reported to preserve the microvascular integrity of ischemia-reperfusion (I/R)-injured tissues." | 1.33 | Diazoxide ameliorates microcirculatory disturbances through PKC-dependent pathway in I/R-injured rat cremaster muscles. ( Hung, LM; Wei, FC; Wei, W, 2005) |
| "Diazoxide pretreatment significantly increased nuclear translocation of p65 which was blocked by protein kinase C (PKC) or nitric oxide synthase (NOS) inhibition." | 1.31 | Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. ( Ashraf, M; Ayub, A; Kudo, M; Wang, Y; Xu, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.50) | 18.2507 |
| 2000's | 21 (52.50) | 29.6817 |
| 2010's | 18 (45.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fernandes de Mattos Dourado, S | 1 |
| Barbeiro, DF | 1 |
| Koike, MK | 1 |
| Barbeiro, HV | 1 |
| Pinheiro da Silva, F | 2 |
| César Machado, MC | 1 |
| Lei, X | 1 |
| Lei, L | 1 |
| Zhang, Z | 2 |
| Cheng, Y | 1 |
| Makepeace, CM | 1 |
| Suarez-Pierre, A | 1 |
| Kanter, EM | 1 |
| Schuessler, RB | 1 |
| Nichols, CG | 1 |
| Lawton, JS | 1 |
| Yamanaka, K | 1 |
| Eldeiry, M | 1 |
| Aftab, M | 1 |
| Ryan, TJ | 1 |
| Roda, G | 1 |
| Meng, X | 1 |
| Weyant, MJ | 1 |
| Cleveland, JC | 1 |
| Fullerton, DA | 1 |
| Reece, TB | 1 |
| Dong, H | 2 |
| Wang, S | 3 |
| Yu, A | 1 |
| Liu, Z | 1 |
| Wang, Y | 3 |
| Harvat, T | 1 |
| Kinzer, K | 1 |
| Zhang, L | 2 |
| Feng, F | 1 |
| Qi, M | 1 |
| Oberholzer, J | 1 |
| Shimizu, S | 1 |
| Oikawa, R | 1 |
| Tsounapi, P | 1 |
| Inoue, K | 1 |
| Shimizu, T | 1 |
| Tanaka, K | 1 |
| Martin, DT | 1 |
| Honda, M | 1 |
| Sejima, T | 1 |
| Tomita, S | 1 |
| Saito, M | 1 |
| Li, Y | 2 |
| Wang, P | 1 |
| Li, S | 1 |
| Guo, Y | 1 |
| Yao, R | 1 |
| Nogueira, MA | 1 |
| Coelho, AM | 1 |
| Sampietre, SN | 1 |
| Patzina, RA | 1 |
| D'Albuquerque, LA | 1 |
| Machado, MC | 1 |
| Yilmaz, TU | 1 |
| Yazihan, N | 1 |
| Dalgic, A | 1 |
| Kaya, EE | 1 |
| Salman, B | 1 |
| Kocak, M | 1 |
| Akcil, E | 1 |
| Dreixler, JC | 3 |
| Shaikh, AR | 3 |
| Shenoy, SK | 1 |
| Shen, Y | 1 |
| Roth, S | 3 |
| Barone, FC | 1 |
| Du, E | 1 |
| Nilakantan, V | 1 |
| Liang, H | 1 |
| Mortensen, J | 1 |
| Taylor, E | 1 |
| Johnson, CP | 1 |
| Assad, AR | 1 |
| Delou, JM | 1 |
| Fonseca, LM | 1 |
| Villela, NR | 1 |
| Nascimento, JH | 1 |
| Verçosa, N | 1 |
| Lopes, AG | 1 |
| Capella, MA | 1 |
| Zarch, AV | 1 |
| Toroudi, HP | 1 |
| Soleimani, M | 3 |
| Bakhtiarian, A | 1 |
| Katebi, M | 1 |
| Djahanguiri, B | 1 |
| Terashima, Y | 1 |
| Sato, T | 1 |
| Yano, T | 1 |
| Maas, O | 1 |
| Itoh, T | 1 |
| Miki, T | 1 |
| Tanno, M | 1 |
| Kuno, A | 1 |
| Shimamoto, K | 1 |
| Miura, T | 1 |
| Wu, Q | 1 |
| Tang, C | 1 |
| Zhang, YJ | 1 |
| Jiang, Y | 1 |
| Li, XW | 1 |
| Wang, SG | 1 |
| Bie, P | 1 |
| Han, JS | 1 |
| Wang, HS | 1 |
| Yan, DM | 1 |
| Wang, ZW | 1 |
| Han, HG | 1 |
| Zhu, HY | 1 |
| Li, XM | 1 |
| Guo, W | 1 |
| Ge, D | 1 |
| Wang, Q | 1 |
| Xu, S | 1 |
| Xue, L | 1 |
| Lu, C | 1 |
| Tan, L | 1 |
| Zeng, Z | 1 |
| Huang, HF | 1 |
| He, F | 1 |
| Wu, LX | 1 |
| Lin, J | 1 |
| Chen, MQ | 1 |
| Farahini, H | 1 |
| Habibey, R | 2 |
| Ajami, M | 2 |
| Davoodi, SH | 1 |
| Azad, N | 1 |
| Tavakkoli-Hosseini, M | 1 |
| Pazoki-Toroudi, H | 2 |
| Moghtadaei, M | 1 |
| Ebrahimi, SA | 1 |
| Rajapakse, N | 1 |
| Shimizu, K | 1 |
| Kis, B | 2 |
| Snipes, J | 1 |
| Lacza, Z | 1 |
| Busija, D | 1 |
| Wang, QL | 1 |
| Wang, G | 1 |
| Wang, HM | 1 |
| Pei, GX | 1 |
| Rahgozar, M | 1 |
| Willgoss, DA | 1 |
| Gobé, GC | 1 |
| Endre, ZH | 1 |
| Kicińska, A | 1 |
| Szewczyk, A | 1 |
| Marina Prendes, MG | 1 |
| Rastelli, AH | 1 |
| Astudilla, C | 1 |
| Fernández, MA | 1 |
| Martínez, M | 1 |
| Perazzo, JC | 1 |
| Testoni, G | 1 |
| Savino, EA | 1 |
| Varela, A | 1 |
| Pompermayer, K | 1 |
| Souza, DG | 1 |
| Lara, GG | 1 |
| Silveira, KD | 1 |
| Cassali, GD | 1 |
| Andrade, AA | 1 |
| Bonjardim, CA | 1 |
| Passaglio, KT | 1 |
| Assreuy, J | 1 |
| Cunha, FQ | 1 |
| Vieira, MA | 1 |
| Teixeira, MM | 1 |
| Wei, W | 1 |
| Wei, FC | 1 |
| Hung, LM | 1 |
| Lenzsér, G | 1 |
| Bari, F | 1 |
| Busija, DW | 1 |
| Lee, KH | 1 |
| Bindokas, V | 1 |
| Roseborough, G | 1 |
| Gao, D | 1 |
| Chen, L | 2 |
| Trush, MA | 1 |
| Zhou, S | 1 |
| Williams, GM | 2 |
| Wei, C | 1 |
| Liu, RG | 1 |
| Wang, WJ | 1 |
| Song, N | 1 |
| Chen, YQ | 1 |
| Li, LH | 1 |
| Gao, H | 1 |
| Yang, HT | 1 |
| He, X | 1 |
| Mo, X | 1 |
| Gu, H | 1 |
| Chen, F | 1 |
| Gu, Q | 1 |
| Peng, W | 1 |
| Qi, J | 1 |
| Shen, L | 1 |
| Sun, J | 1 |
| Zhang, R | 1 |
| Kj, Y | 1 |
| Sun, Z | 1 |
| Zhang, X | 1 |
| Ito, K | 1 |
| Montgomery, RA | 1 |
| Tachibana, S | 1 |
| Bouskela, E | 1 |
| Cyrino, FZ | 1 |
| Conde, CM | 1 |
| Garcia, AA | 1 |
| Tanhehco, EJ | 1 |
| Yasojima, K | 1 |
| McGeer, PL | 1 |
| McGeer, EG | 1 |
| Lucchesi, BR | 1 |
| Takashi, E | 1 |
| Xu, M | 2 |
| Ayub, A | 2 |
| Ashraf, M | 2 |
| Kudo, M | 1 |
40 other studies available for diazoxide and Reperfusion Injury
| Article | Year |
|---|---|
Diazoxide reduces local and remote organ damage in a rat model of intestinal ischemia reperfusion.
Topics: Animals; Aspartate Aminotransferases; Cyclooxygenase 2; Diazoxide; Disease Models, Animal; Heart; Hu | 2018 |
Diazoxide inhibits of ER stress‑mediated apoptosis during oxygen‑glucose deprivation in vitro and cerebral ischemia‑reperfusion in vivo.
Topics: Animals; Apoptosis; Brain Ischemia; Diazoxide; Endoplasmic Reticulum Stress; Female; Glucose; Heat-S | 2018 |
Superior diastolic function with K
Topics: Animals; Cardiotonic Agents; Coronary Vessels; Diastole; Diazoxide; Disease Models, Animal; Heart; H | 2018 |
Pretreatment With Diazoxide Attenuates Spinal Cord Ischemia-Reperfusion Injury Through Signaling Transducer and Activator of Transcription 3 Pathway.
Topics: Administration, Oral; Animals; Blotting, Western; Diazoxide; Disease Models, Animal; Male; Mice; Mic | 2019 |
The effect of mitochondrial calcium uniporter opener spermine on diazoxide against focal cerebral ischemia--reperfusion injury in rats.
Topics: Animals; Behavior, Animal; Brain; Calcium Channels; Cerebral Infarction; Cytoprotection; Diazoxide; | 2014 |
Diazoxide, a K(ATP) channel opener, prevents ischemia-reperfusion injury in rodent pancreatic islets.
Topics: Animals; Antihypertensive Agents; Apoptosis; Diazoxide; Insulin; Insulin Secretion; Islets of Langer | 2015 |
Blocking of the ATP sensitive potassium channel ameliorates the ischaemia-reperfusion injury in the rat testis.
Topics: Animals; Apoptosis; Cromakalim; Decanoic Acids; Diazoxide; Glyburide; Hydroxy Acids; KATP Channels; | 2014 |
Spermine attenuates the preconditioning of diazoxide against transient focal cerebral ischemia in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Calcium Channels; Cytochromes c; Diazoxide; I | 2014 |
Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury.
Topics: Animals; Biomarkers; Diazoxide; Disease Models, Animal; Inflammation; Inflammation Mediators; Liver; | 2014 |
Role of ATP-dependent K channels in the effects of erythropoietin in renal ischaemia injury.
Topics: Apoptosis; Cell Line; Cell Proliferation; Diazoxide; Erythropoietin; Gene Expression Regulation; Hum | 2015 |
Protein kinase C subtypes and retinal ischemic preconditioning.
Topics: Acetophenones; Animals; Apoptosis; Benzopyrans; Blotting, Western; Cells, Cultured; Diazoxide; Elect | 2008 |
Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Anisomycin; Diazoxide | 2009 |
Variable effects of the mitoK(ATP) channel modulators diazoxide and 5-HD in ATP-depleted renal epithelial cells.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Diazoxide; Epithelial Cells; Hydroxy Acids; Kidney; | 2010 |
The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion.
Topics: Adenosine Triphosphate; Animals; Antimycin A; Apoptosis; Cell Survival; Cytoprotection; Decanoic Aci | 2009 |
Neuroprotective effects of diazoxide and its antagonism by glibenclamide in pyramidal neurons of rat hippocampus subjected to ischemia-reperfusion-induced injury.
Topics: Animals; bcl-2-Associated X Protein; Blotting, Western; Cell Death; Diazoxide; Diuretics; Gene Expre | 2009 |
Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial K ATP channel.
Topics: Adenosine A2 Receptor Antagonists; Animals; Cyclophilins; Diazoxide; Glycogen Synthase Kinase 3; Gly | 2010 |
Diazoxide suppresses hepatic ischemia/reperfusion injury after mouse liver transplantation by a BCL-2-dependent mechanism.
Topics: Animals; Apoptosis; Cytochromes c; Cytosol; Diazoxide; Liver; Liver Transplantation; Male; Mice; Mic | 2011 |
Myocardial ischaemic and diazoxide preconditioning both increase PGC-1alpha and reduce mitochondrial damage.
Topics: Animals; Diazoxide; Dimethyl Sulfoxide; Immunohistochemistry; Ischemic Preconditioning, Myocardial; | 2010 |
Diazoxide decreases ischemia-reperfusion injury in a rat model of lung transplantation.
Topics: Animals; Cytokines; Diazoxide; Lung; Lung Transplantation; Male; Malondialdehyde; Oxygen; Peroxidase | 2011 |
Diazoxide attenuates ischemia/reperfusion injury via upregulation of heme oxygenase-1 after liver transplantation in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cytokines; Diazoxide; Heme Oxygenase (De | 2012 |
Late anti-apoptotic effect of K(ATP) channel opening in skeletal muscle.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Catalase; Cell Nucleus; Diazoxide; DNA Fragmentation | 2012 |
Skeletal muscle post-conditioning by diazoxide, anti-oxidative and anti-apoptotic mechanisms.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Catalase; Cell Nucleus; Decanoic Acids; Diazoxide; H | 2012 |
Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain; Carotid Arteries; Cell Death; Diazoxide; Micros | 2002 |
Effect of pretreatment with adenosine, diazoxide or ischemic preconditioning on ischemia- reperfusion injury in the limbs of rats.
Topics: Adenosine; Animals; Creatine Kinase; Diazoxide; Disease Models, Animal; Extremities; Ischemic Precon | 2002 |
ATP-dependent K+ channels in renal ischemia reperfusion injury.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Cromakalim; Diazoxide; Disease Models, Animal; | 2003 |
Protective effects of the potassium channel opener-diazoxide against injury in neonatal rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Apoptosis; Cardiotonic Agents; Cell Line; Decanoic Acids; Diazoxide; Dose | 2003 |
Influence of fasting on the effects of diazoxide in the ischemic-reperfused rat heart.
Topics: Animals; Diazoxide; Fasting; Female; Ischemic Preconditioning; Male; Potassium Channels; Rats; Rats, | 2004 |
The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats.
Topics: Adenosine Triphosphate; Animals; Cytokines; Diazoxide; Disease Models, Animal; Glyburide; Interleuki | 2005 |
Diazoxide ameliorates microcirculatory disturbances through PKC-dependent pathway in I/R-injured rat cremaster muscles.
Topics: Abdominal Muscles; Alkaloids; Animals; Benzophenanthridines; Cell Adhesion Molecules; Cell Movement; | 2005 |
Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Capillary Permeability; Diazoxide; | 2005 |
Mitochondrial potassium ATP channels and retinal ischemic preconditioning.
Topics: Animals; Decanoic Acids; Diazoxide; Electroretinography; Fluorescent Antibody Technique, Indirect; H | 2006 |
The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord.
Topics: Animals; Apoptosis; Cell Death; Diazoxide; DNA Damage; DNA Glycosylases; DNA Repair; Mitochondria; M | 2006 |
Diazoxide preconditioning alleviates apoptosis of hippocampal neurons induced by anoxia-reoxygenation in vitro through up-regulation of Bcl-2/Bax protein ratio.
Topics: Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Cell Hypoxia; Diazoxide; Hippocamp | 2006 |
Activation of alpha1B-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca2+ overload in cardiomyocytes.
Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Anima | 2007 |
Neuroprotective effect of diazoxide on brain injury induced by cerebral ischemia/reperfusion during deep hypothermia.
Topics: Analysis of Variance; Animals; Brain Injuries; Caspase 3; Cerebrovascular Circulation; Cytochromes c | 2008 |
Amelioration of oxidative mitochondrial DNA damage and deletion after renal ischemic injury by the KATP channel opener diazoxide.
Topics: Animals; Apoptosis; Diazoxide; DNA, Mitochondrial; Free Radicals; Kidney Diseases; Kidney Function T | 2008 |
Microvascular permeability with sulfonylureas in normal and diabetic hamsters.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Capillary Permeability; Cricetinae; Dextrans; D | 1997 |
Preconditioning reduces myocardial complement gene expression in vivo.
Topics: Animals; Anti-Arrhythmia Agents; Blotting, Western; Complement System Proteins; Decanoic Acids; Diaz | 2000 |
Downregulation of protein kinase C inhibits activation of mitochondrial K(ATP) channels by diazoxide.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Dose-Response Relationship, Drug; Down-Regulation; Immun | 2001 |
Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide.
Topics: Acetophenones; Active Transport, Cell Nucleus; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agen | 2001 |