Page last updated: 2024-10-25

diazoxide and Pulmonary Hypertension

diazoxide has been researched along with Pulmonary Hypertension in 36 studies

Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.

Research Excerpts

ExcerptRelevanceReference
"Diazoxide is the first line and only Federal Drug Agency approved pharmacological agent for the treatment of hyperinsulinism."9.30Rate of Serious Adverse Events Associated with Diazoxide Treatment of Patients with Hyperinsulinism. ( Hamby, T; Nedrelow, J; Reynolds, C; Thornton, P; Truong, L, 2019)
"Diazoxide, a drug used to treat hyperinsulinemic hypoglycemia (HH), is associated with pulmonary hypertension (PH), as reported by the US Food and Drug Administration."7.96Pulmonary Hypertension Following Increased Dosing of Diazoxide in an Infant. ( Hasegawa, S; Kimura, S; Ohnishi, Y; Okada, S; Suzuki, Y; Yasudo, H, 2020)
"Diazoxide is first-line treatment for hyperinsulinaemic hypoglycaemia (HH) but diazoxide-induced pulmonary hypertension (PH) can occur."7.91Diazoxide-induced pulmonary hypertension in hyperinsulinaemic hypoglycaemia: Recommendations from a multicentre study in the United Kingdom. ( Aftab, S; Banerjee, I; Bath, L; Chen, SC; Christov, G; Dastamani, A; Giardini, A; Hunter, L; Pintus, D; Senniappan, S; Shah, P; Shaikh, MG; Swinburne, C; Yau, D, 2019)
" The relatively high prevalence of neutropenia, thrombocytopenia, and hyperuricemia suggests the value in proactively screening for these side effects in children treated with diazoxide."7.88Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide. ( Avitabile, CM; De León, DD; Givler, S; Herrera, A; Lord, K; Mitteer, L; Vajravelu, ME, 2018)
"Diazoxide is the main therapeutic agent for persistent hyperinsulinemic hypoglycemia."7.77Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide. ( Arasli, A; Çetin, II; Demirel, F; Esen, I; Unal, S, 2011)
"Diazoxide is commonly used in the treatment of neonatal hyperinsulinism."7.74Development of pulmonary hypertension in an infant treated with diazoxide. ( Caldwell, RL; Eugster, EA; Hoover, WC; Nebesio, TD; Nitu, ME, 2007)
"Hemodynamic effects were studied after the administration of incremental doses of diazoxide (upper range 300-600 mg) in a group of 15 patients with severe pulmonary hypertension due to different etiologies."7.68[Effect of diazoxide on severe pulmonary hypertension]. ( Raimondi, GA, 1990)
"The use of diazoxide in the treatment of pulmonary hypertension has been advocated recently."7.66Hazards of diazoxide in pulmonary hypertension. ( Buch, J; Wennevold, A, 1981)
"Diazoxide was injected into the pulmonary artery in nine patients with primary pulmonary hypertension."7.66Clinical and haemodynamic effects of diazoxide in primary pulmonary hypertension. ( Cotter, L; Davies, N; Denison, D; Honey, M, 1980)
"Three patients with primary pulmonary hypertension and one man with suspected thromboembolic pulmonary hypertension were given up to 300 mg diazoxide by injection into the pulmonary artery."7.66Diazoxide in treatment of primary pulmonary hypertension. ( Pohl, JE; Rowlands, DJ; Wade, EG; Wang, SW, 1978)
"Diazoxide treatment remains the mainstay of medical therapy."5.35Pulmonary hypertension, heart failure and neutropenia due to diazoxide therapy. ( Erdem, S; Küçükosmanoglu, O; Yildizdas, D; Yilmaz, M; Yüksel, B, 2008)
"Diazoxide is the first line and only Federal Drug Agency approved pharmacological agent for the treatment of hyperinsulinism."5.30Rate of Serious Adverse Events Associated with Diazoxide Treatment of Patients with Hyperinsulinism. ( Hamby, T; Nedrelow, J; Reynolds, C; Thornton, P; Truong, L, 2019)
"When diazoxide was discontinued on two separate occasions pulmonary hypertension recurred."5.27Reversibility of primary pulmonary hypertension during six years of treatment with oral diazoxide. ( Chan, NS; Kenmure, AC; McLay, J, 1987)
"Diazoxide, a drug used to treat hyperinsulinemic hypoglycemia (HH), is associated with pulmonary hypertension (PH), as reported by the US Food and Drug Administration."3.96Pulmonary Hypertension Following Increased Dosing of Diazoxide in an Infant. ( Hasegawa, S; Kimura, S; Ohnishi, Y; Okada, S; Suzuki, Y; Yasudo, H, 2020)
"Diazoxide is first-line treatment for hyperinsulinaemic hypoglycaemia (HH) but diazoxide-induced pulmonary hypertension (PH) can occur."3.91Diazoxide-induced pulmonary hypertension in hyperinsulinaemic hypoglycaemia: Recommendations from a multicentre study in the United Kingdom. ( Aftab, S; Banerjee, I; Bath, L; Chen, SC; Christov, G; Dastamani, A; Giardini, A; Hunter, L; Pintus, D; Senniappan, S; Shah, P; Shaikh, MG; Swinburne, C; Yau, D, 2019)
" The relatively high prevalence of neutropenia, thrombocytopenia, and hyperuricemia suggests the value in proactively screening for these side effects in children treated with diazoxide."3.88Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide. ( Avitabile, CM; De León, DD; Givler, S; Herrera, A; Lord, K; Mitteer, L; Vajravelu, ME, 2018)
"Diazoxide is the main therapeutic agent for persistent hyperinsulinemic hypoglycemia."3.77Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide. ( Arasli, A; Çetin, II; Demirel, F; Esen, I; Unal, S, 2011)
"Diazoxide is commonly used in the treatment of neonatal hyperinsulinism."3.74Development of pulmonary hypertension in an infant treated with diazoxide. ( Caldwell, RL; Eugster, EA; Hoover, WC; Nebesio, TD; Nitu, ME, 2007)
"Hemodynamic effects were studied after the administration of incremental doses of diazoxide (upper range 300-600 mg) in a group of 15 patients with severe pulmonary hypertension due to different etiologies."3.68[Effect of diazoxide on severe pulmonary hypertension]. ( Raimondi, GA, 1990)
"The use of diazoxide in the treatment of pulmonary hypertension has been advocated recently."3.66Hazards of diazoxide in pulmonary hypertension. ( Buch, J; Wennevold, A, 1981)
"Diazoxide was injected into the pulmonary artery in nine patients with primary pulmonary hypertension."3.66Clinical and haemodynamic effects of diazoxide in primary pulmonary hypertension. ( Cotter, L; Davies, N; Denison, D; Honey, M, 1980)
"Three patients with primary pulmonary hypertension and one man with suspected thromboembolic pulmonary hypertension were given up to 300 mg diazoxide by injection into the pulmonary artery."3.66Diazoxide in treatment of primary pulmonary hypertension. ( Pohl, JE; Rowlands, DJ; Wade, EG; Wang, SW, 1978)
"Pulmonary hypertension is frequently observed in some cardiac malformation and in congenital diaphragmatic hernia, in meconium aspiration syndrome, neonatal sepsis, podalic presentation and male sex."2.44Drug-induced pulmonary hypertension in newborns: a review. ( Camporesi, A; Silvani, P, 2007)
"Diazoxide treatment remains the mainstay of medical therapy."1.35Pulmonary hypertension, heart failure and neutropenia due to diazoxide therapy. ( Erdem, S; Küçükosmanoglu, O; Yildizdas, D; Yilmaz, M; Yüksel, B, 2008)
"When diazoxide was discontinued on two separate occasions pulmonary hypertension recurred."1.27Reversibility of primary pulmonary hypertension during six years of treatment with oral diazoxide. ( Chan, NS; Kenmure, AC; McLay, J, 1987)
"Isosorbide dinitrate was the only drug that elicited any reduction in pulmonary artery pressure; pulmonary vascular resistance decreased modestly."1.26Vasodilators and prostaglandin inhibitors in primary pulmonary hypertension. ( Bambach, D; Fontana, ME; Hermiller, JB; Huss, P; Leier, CV; Magorien, RD; Thompson, MJ; Unverferth, DV, 1982)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199026 (72.22)18.7374
1990's1 (2.78)18.2507
2000's3 (8.33)29.6817
2010's5 (13.89)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Chen, SC1
Dastamani, A1
Pintus, D1
Yau, D1
Aftab, S1
Bath, L1
Swinburne, C1
Hunter, L1
Giardini, A1
Christov, G1
Senniappan, S1
Banerjee, I1
Shaikh, MG1
Shah, P1
Ohnishi, Y1
Okada, S1
Yasudo, H1
Kimura, S1
Suzuki, Y1
Hasegawa, S1
Timlin, MR1
Black, AB1
Delaney, HM1
Matos, RI1
Percival, CS1
Herrera, A1
Vajravelu, ME1
Givler, S1
Mitteer, L1
Avitabile, CM1
Lord, K1
De León, DD1
Thornton, P1
Truong, L1
Reynolds, C1
Hamby, T1
Nedrelow, J1
Yildizdas, D1
Erdem, S1
Küçükosmanoglu, O1
Yilmaz, M1
Yüksel, B1
Demirel, F1
Unal, S1
Çetin, II1
Esen, I1
Arasli, A1
ROWE, GG1
LEICHT, TR1
BOAKE, WC1
KYLE, JC1
CRUMPTON, CW1
Silvani, P1
Camporesi, A1
Nebesio, TD1
Hoover, WC1
Caldwell, RL1
Nitu, ME1
Eugster, EA1
Peter, RH2
Rubin, L1
Cotter, L3
Pannarale, G2
Gaspardone, A2
Acconcia, MC2
Valente, A2
Hall, DR2
Rich, S1
Martinez, J1
Lam, W1
Levy, PS1
Rosen, KM1
Berkenboom, G1
Sobolski, J1
Stoupel, E1
Hermiller, JB1
Bambach, D1
Thompson, MJ1
Huss, P1
Fontana, ME1
Magorien, RD1
Unverferth, DV1
Leier, CV1
Buch, J1
Wennevold, A1
Reeves, JT1
Klinke, WP2
Gilbert, JA1
Honey, M2
Camerini, F1
Alberti, E1
Klugmann, S1
Salvi, A1
Davies, N1
Denison, D1
Rubin, LJ2
Thomas, D1
Drobinski, G1
Komajda, M1
Grosgogeat, Y1
Elkayam, U1
Rubino, JM1
Schroeder, JS1
Wang, SW1
Pohl, JE1
Rowlands, DJ1
Wade, EG1
Fleischmann, LE1
Raimondi, GA1
Hughes, JD1
Petch, MC1
Chan, NS1
McLay, J1
Kenmure, AC1
Both, A1

Reviews

5 reviews available for diazoxide and Pulmonary Hypertension

ArticleYear
Development of Pulmonary Hypertension During Treatment with Diazoxide: A Case Series and Literature Review.
    Pediatric cardiology, 2017, Volume: 38, Issue:6

    Topics: Congenital Hyperinsulinism; Diazoxide; Humans; Hypertension, Pulmonary; Infant, Newborn; Insulin Ant

2017
Drug-induced pulmonary hypertension in newborns: a review.
    Current vascular pharmacology, 2007, Volume: 5, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Circulation; Diazoxide; Humans; Hypertension

2007
The pharmacologic control of the pulmonary circulation in pulmonary hypertension.
    Advances in internal medicine, 1984, Volume: 29

    Topics: Acetylcholine; Adult; Aminophylline; Calcium Channel Blockers; Diazoxide; Female; Humans; Hydralazin

1984
[Early pulmonary hypertension: current therapeutic prospectives].
    Cardiologia (Rome, Italy), 1982, Volume: 27, Issue:9

    Topics: Calcium Channel Blockers; Captopril; Diazoxide; Diltiazem; Humans; Hydralazine; Hypertension, Pulmon

1982
Primary pulmonary hypertension. An analysis of 28 cases and a review of the literature.
    Medicine, 1986, Volume: 65, Issue:1

    Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aminorex; Anticoagulants; Autoimmune Diseases; Calc

1986

Trials

1 trial available for diazoxide and Pulmonary Hypertension

ArticleYear
Rate of Serious Adverse Events Associated with Diazoxide Treatment of Patients with Hyperinsulinism.
    Hormone research in paediatrics, 2019, Volume: 91, Issue:1

    Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hypertension, Pulmonary; Infant; Infant, Newborn; Male;

2019

Other Studies

30 other studies available for diazoxide and Pulmonary Hypertension

ArticleYear
Diazoxide-induced pulmonary hypertension in hyperinsulinaemic hypoglycaemia: Recommendations from a multicentre study in the United Kingdom.
    Clinical endocrinology, 2019, Volume: 91, Issue:6

    Topics: Congenital Hyperinsulinism; Diazoxide; Echocardiography; Female; Gestational Age; Humans; Hypertensi

2019
Pulmonary Hypertension Following Increased Dosing of Diazoxide in an Infant.
    International heart journal, 2020, Sep-29, Volume: 61, Issue:5

    Topics: Atrial Natriuretic Factor; Beckwith-Wiedemann Syndrome; Cardiac Catheterization; Congenital Hyperins

2020
Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide.
    The Journal of clinical endocrinology and metabolism, 2018, 12-01, Volume: 103, Issue:12

    Topics: Congenital Hyperinsulinism; Diazoxide; Dose-Response Relationship, Drug; Drug Administration Schedul

2018
Pulmonary hypertension, heart failure and neutropenia due to diazoxide therapy.
    Advances in therapy, 2008, Volume: 25, Issue:5

    Topics: Congenital Hyperinsulinism; Diazoxide; Female; Heart Failure; Humans; Hypertension, Pulmonary; Infan

2008
Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide.
    Journal of pediatric endocrinology & metabolism : JPEM, 2011, Volume: 24, Issue:7-8

    Topics: Diagnosis, Differential; Diazoxide; Ductus Arteriosus, Patent; Humans; Hyperinsulinism; Hypertension

2011
THE SYSTEMIC AND CORONARY HEMODYNAMIC EFFECTS OF DIAZOXIDE.
    American heart journal, 1963, Volume: 66

    Topics: Arrhythmias, Cardiac; Benzothiadiazines; Blood Circulation; Blood Pressure; Chlorothiazide; Coronary

1963
Development of pulmonary hypertension in an infant treated with diazoxide.
    Journal of pediatric endocrinology & metabolism : JPEM, 2007, Volume: 20, Issue:8

    Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hypertension, Pulmonary; Hypoglycemia; Hypoglycemic Agen

2007
Vasodilator treatment of primary pulmonary hypertension.
    Advances in experimental medicine and biology, 1984, Volume: 164

    Topics: Administration, Oral; Adult; Diazoxide; Female; Humans; Hydralazine; Hypertension, Pulmonary; Middle

1984
Remission of primary pulmonary hypertension during treatment with diazoxide.
    British medical journal (Clinical research ed.), 1981, Apr-04, Volume: 282, Issue:6270

    Topics: Adult; Diazoxide; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Time Factors

1981
Reassessment of the effects of vasodilator drugs in primary pulmonary hypertension: guidelines for determining a pulmonary vasodilator response.
    American heart journal, 1983, Volume: 105, Issue:1

    Topics: Adult; Blood Pressure; Cardiac Catheterization; Cardiac Output; Diazoxide; Female; Humans; Hydralazi

1983
[Primary pulmonary hypertension: current therapeutic prospectives].
    Cardiologia (Rome, Italy), 1982, Volume: 27, Issue:9

    Topics: Calcium Channel Blockers; Diazoxide; Heart Rate; Humans; Hydralazine; Hypertension, Pulmonary; Isopr

1982
Failure of nifedipine treatment in primary pulmonary hypertension.
    British heart journal, 1982, Volume: 47, Issue:5

    Topics: Adult; Diazoxide; Female; Humans; Hypertension, Pulmonary; Nifedipine; Pyridines

1982
Vasodilators and prostaglandin inhibitors in primary pulmonary hypertension.
    Annals of internal medicine, 1982, Volume: 97, Issue:4

    Topics: Adolescent; Adult; Aspirin; Diazoxide; Dipyridamole; Female; Hemodynamics; Humans; Hydralazine; Hype

1982
Hazards of diazoxide in pulmonary hypertension.
    British heart journal, 1981, Volume: 46, Issue:4

    Topics: Abdomen; Adolescent; Adult; Diazoxide; Female; Heart Arrest; Heart Block; Humans; Hypertension, Pulm

1981
Hope in primary pulmonary hypertension.
    The New England journal of medicine, 1980, Jan-10, Volume: 302, Issue:2

    Topics: Child; Diazoxide; Female; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Pregnancy; Tim

1980
Diazoxide in primary pulmonary hypertension.
    The New England journal of medicine, 1980, Jan-10, Volume: 302, Issue:2

    Topics: Administration, Oral; Adult; Diazoxide; Drug Evaluation; Female; Hemodynamics; Humans; Hypertension,

1980
Vasodilator therapy for pulmonary hypertension.
    The New England journal of medicine, 1980, May-29, Volume: 302, Issue:22

    Topics: Administration, Oral; Diazoxide; Humans; Hypertension, Pulmonary

1980
Treatment for primary pulmonary hypertension.
    American heart journal, 1980, Volume: 100, Issue:4

    Topics: Diazoxide; Humans; Hypertension, Pulmonary; Isoproterenol; Oxygen Inhalation Therapy; Phentolamine

1980
Primary pulmonary hypertension: effects of nifedipine.
    British heart journal, 1980, Volume: 44, Issue:3

    Topics: Adult; Diazoxide; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Nifedipine; Pulmonary Arter

1980
Clinical and haemodynamic effects of diazoxide in primary pulmonary hypertension.
    Thorax, 1980, Volume: 35, Issue:4

    Topics: Administration, Oral; Adult; Blood Pressure; Cardiac Catheterization; Diazoxide; Female; Humans; Hyp

1980
Primary pulmonary hypertension: new approaches to therapy.
    American heart journal, 1980, Volume: 100, Issue:5

    Topics: Diazoxide; Female; Humans; Hydralazine; Hypertension, Pulmonary; Phentolamine; Pregnancy

1980
[Primary pulmonary arterial hypertension. Trial treatment with nifedipine, diazoxide and isoproterenol].
    La Nouvelle presse medicale, 1980, Dec-20, Volume: 9, Issue:48

    Topics: Diazoxide; Drug Therapy, Combination; Female; Humans; Hypertension, Pulmonary; Isoproterenol; Middle

1980
Vasodilator therapy in primary pulmonary hypertension.
    Chest, 1981, Volume: 79, Issue:3

    Topics: Adult; Diazoxide; Female; Hemodynamics; Humans; Hydralazine; Hypertension, Pulmonary; Isoproterenol;

1981
Diazoxide in treatment of primary pulmonary hypertension.
    British heart journal, 1979, Volume: 42, Issue:3

    Topics: Adult; Diazoxide; Female; Humans; Hypertension, Pulmonary; Injections, Intra-Arterial; Pulmonary Art

1979
Diazoxide in treatment of primary pulmonary hypertension.
    British heart journal, 1978, Volume: 40, Issue:5

    Topics: Adult; Cardiac Output; Diazoxide; Female; Humans; Hypertension, Pulmonary; Injections, Intra-Arteria

1978
Management of hypertensive crisis in children.
    Pediatric annals, 1977, Volume: 6, Issue:6

    Topics: Acute Disease; Adolescent; Cerebrovascular Disorders; Child; Child, Preschool; Diazoxide; Humans; Hy

1977
[Effect of diazoxide on severe pulmonary hypertension].
    Medicina, 1990, Volume: 50, Issue:3

    Topics: Adult; Aged; Blood Pressure; Diazoxide; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Lung

1990
Reversibility of primary pulmonary hypertension during six years of treatment with oral diazoxide.
    British heart journal, 1987, Volume: 58, Issue:4

    Topics: Diazoxide; Female; Humans; Hypertension, Pulmonary

1987
Reversibility of primary pulmonary hypertension during six years of treatment with oral diazoxide.
    British heart journal, 1987, Volume: 57, Issue:2

    Topics: Adult; Blood Pressure; Diazoxide; Female; Humans; Hypertension, Pulmonary; Pulmonary Artery

1987
[Therapy of primary pulmonary hypertension].
    Zeitschrift fur Kreislaufforschung, 1970, Volume: 59, Issue:10

    Topics: Acetylcholine; Amino Alcohols; Carbachol; Child; Diazepam; Diazoxide; Female; Humans; Hypertension,

1970