diazoxide has been researched along with Pancreatic Diseases in 32 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Pancreatic Diseases: Pathological processes of the PANCREAS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperinsulinemic hypoglycemia secondary to nesidioblastosis persisted in a 4-year-old girl despite a 95% pancreatectomy and high-dose diazoxide treatment." | 3.66 | Persistent leucine sensitivity following partial pancreatectomy and diazoxide treatment. Therapeutic response. ( Bradvica, C; Golden, MP; Graham, MJ; Santiago, J; Sargeant, DT; White, NH; Zuniga, O, 1983) |
| "Treatment with diazoxide and chlorthiazide is highly effective, appears to be safe, and does not need to be continued lifelong." | 1.33 | Hyperinsulinism in tyrosinaemia type I. ( Baumann, U; Green, A; Kelly, DA; McKiernan, PJ; Preece, MA, 2005) |
| "Diazoxide was useful in the treatment of three patients but many side-effects were observed." | 1.28 | Hyperinsulinism in infancy. ( Chow, OK; Low, LC; Yeung, CY; Young, RT; Yu, EC, 1989) |
| "They suffered serious side effects of cardiac failure and truncal ataxia." | 1.27 | Complications of diazoxide in the treatment of nesidioblastosis. ( McGraw, ME; Price, DA, 1985) |
| "To avoid mental retardation, surgical intervention should not be considered as a last resort." | 1.26 | Near-total pancreatectomy in persistent infantile hypoglycemia. ( Moazam, F; Rodgers, BM; Rosenbloom, AL; Talbert, JL, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (65.63) | 18.7374 |
| 1990's | 8 (25.00) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Manocha, D | 1 |
| Shah, R | 1 |
| Vaidya, GN | 1 |
| Bansal, N | 1 |
| DRASH, A | 1 |
| WOLFF, F | 1 |
| Baumann, U | 1 |
| Preece, MA | 1 |
| Green, A | 1 |
| Kelly, DA | 1 |
| McKiernan, PJ | 1 |
| Moazam, F | 1 |
| Rodgers, BM | 1 |
| Talbert, JL | 1 |
| Rosenbloom, AL | 1 |
| Zuniga, O | 1 |
| Golden, MP | 1 |
| Sargeant, DT | 1 |
| Graham, MJ | 1 |
| Bradvica, C | 1 |
| Santiago, J | 1 |
| White, NH | 1 |
| Aynsley-Green, A | 1 |
| Polak, JM | 1 |
| Bloom, SR | 1 |
| Gough, MH | 1 |
| Keeling, J | 1 |
| Ashcroft, SJ | 1 |
| Turner, RC | 1 |
| Baum, JD | 1 |
| Chrousos, GP | 1 |
| Wachlicht-Rodbard, H | 1 |
| Adams, AJ | 1 |
| Roth, J | 1 |
| Cornblath, M | 2 |
| Leibowitz, G | 1 |
| Glaser, B | 2 |
| Higazi, AA | 1 |
| Salameh, M | 1 |
| Cerasi, E | 1 |
| Landau, H | 2 |
| Williams, AJ | 1 |
| Beales, PE | 1 |
| Krug, J | 1 |
| Procaccini, E | 1 |
| Signore, A | 1 |
| Xu, S | 1 |
| Gale, EA | 1 |
| Pozzilli, P | 1 |
| Yasukura, K | 1 |
| Ono, A | 1 |
| Woo, M | 1 |
| Matsuzaki, S | 1 |
| Iwase, S | 1 |
| Kobayashi, Y | 1 |
| Daneman, D | 1 |
| Ehrlich, RM | 1 |
| Hirsch, HJ | 1 |
| de Lonlay-Debeney, P | 1 |
| Fournet, JC | 1 |
| Martin, D | 1 |
| Poggi, F | 1 |
| Dionisi Vicci, C | 1 |
| Spada, M | 1 |
| Touati, G | 1 |
| Rahier, J | 1 |
| Brunelle, F | 1 |
| Junien, C | 1 |
| Robert, JJ | 1 |
| Nihoul-Fékété, C | 1 |
| Saudubray, JM | 1 |
| Yoshikawa, H | 1 |
| Tajiri, Y | 1 |
| Sako, Y | 1 |
| Hashimato, T | 1 |
| Umeda, F | 1 |
| Nawata, H | 1 |
| Uebersax, R | 1 |
| Jeanmonod, D | 1 |
| Meyrat, CA | 1 |
| Scandellari, C | 1 |
| Zaccaria, M | 1 |
| Sicolo, N | 1 |
| Casara, D | 1 |
| Erle, G | 1 |
| Federspil, G | 1 |
| Andreani, D | 1 |
| Tamburrano, S | 1 |
| Tamburrano, G | 1 |
| Natoli, C | 1 |
| Schikman, CH | 1 |
| Chertow, BS | 1 |
| Fariss, BL | 1 |
| Harris, JP | 1 |
| Ricker, AT | 1 |
| Bjerke, HS | 1 |
| Kelly, RE | 1 |
| Geffner, ME | 1 |
| Fonkalsrud, EW | 1 |
| Low, LC | 1 |
| Yu, EC | 1 |
| Chow, OK | 1 |
| Yeung, CY | 1 |
| Young, RT | 1 |
| Grant, DB | 1 |
| Dunger, DB | 1 |
| Burns, EC | 1 |
| Rose, SR | 1 |
| Chrousos, G | 1 |
| Sidbury, J | 1 |
| McGraw, ME | 1 |
| Price, DA | 1 |
| Gillies, DR | 1 |
| Bell, WE | 1 |
| Samaan, NA | 1 |
| Longnecker, DS | 1 |
| Hellman, B | 1 |
| Idahl, LA | 1 |
| Pagliara, AS | 1 |
| Karl, IE | 1 |
| Haymond, M | 1 |
| Kipnis, DM | 1 |
| Yoshinaga, T | 1 |
| Isshiki, G | 1 |
| Okuno, G | 1 |
| Ueda, T | 1 |
| Ogawa, S | 1 |
| Brunetti, P | 1 |
| Santeusanio, F | 1 |
| Arena, D | 1 |
| Palumbo, R | 1 |
| Puxeddu, A | 1 |
| De Ciuceis, P | 1 |
| Calabrese, G | 1 |
| Senft, G | 1 |
| Laroche, C | 1 |
| Grégoire, J | 1 |
| Caquet, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use for Diazoxide in the Initial Management of Hypoglycemia in Infants of Diabetic Mothers and Infants Large for Gestation[NCT00994149] | Phase 2/Phase 3 | 100 participants (Anticipated) | Interventional | 2009-10-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for diazoxide and Pancreatic Diseases
| Article | Year |
|---|---|
[Persistent hyperinsulinemic hypoglycemia in the newborn and infants].
Topics: Diazoxide; Diuretics; Genetic Counseling; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, New | 1998 |
Hypoglycemia in infancy and childhood. II.
Topics: Adrenal Cortex Hormones; Adrenal Gland Diseases; Amino Acids; Carbohydrate Metabolism, Inborn Errors | 1973 |
30 other studies available for diazoxide and Pancreatic Diseases
| Article | Year |
|---|---|
Refractory hypoglycaemia in patient with gastric outlet obstruction.
Topics: Aged; Angiography; Diazoxide; Endosonography; Gastric Bypass; Gastric Outlet Obstruction; Glucose; H | 2015 |
DRUG THERAPY IN LEUCINE-SENSITIVE HYPOGLYCEMIA.
Topics: Antihypertensive Agents; Benzothiadiazines; Child; Diazoxide; Dietary Carbohydrates; Dietary Protein | 1964 |
Hyperinsulinism in tyrosinaemia type I.
Topics: Blood Glucose; C-Peptide; Chlorothiazide; Diazoxide; Diuretics; Humans; Hyperinsulinism; Hypoglycemi | 2005 |
Near-total pancreatectomy in persistent infantile hypoglycemia.
Topics: Adenoma; Adenoma, Islet Cell; Diazoxide; Female; Humans; Hyperplasia; Hypoglycemia; Infant; Infant, | 1982 |
Persistent leucine sensitivity following partial pancreatectomy and diazoxide treatment. Therapeutic response.
Topics: Child, Preschool; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Leucine; Pancreatectomy; | 1983 |
Nesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia.
Topics: Diazoxide; Female; Glucose; Humans; Hyperinsulinism; Hypoglycemia; In Vitro Techniques; Infant, Newb | 1981 |
Increased 125I-insulin receptor binding to erythrocytes of hypoglycemic infants and children.
Topics: Adolescent; Adult; Blood Glucose; Child, Preschool; Diazoxide; Erythrocytes; Female; Glycogen Storag | 1981 |
Hyperinsulinemic hypoglycemia of infancy (nesidioblastosis) in clinical remission: high incidence of diabetes mellitus and persistent beta-cell dysfunction at long-term follow-up.
Topics: Adolescent; C-Peptide; Child; Diabetes Mellitus; Diazoxide; Female; Follow-Up Studies; Glucose Toler | 1995 |
Tolbutamide reduces the incidence of diabetes mellitus, but not insulitis, in the non-obese-diabetic mouse.
Topics: Aging; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diazoxide; Female; Insulin; Islets of Lang | 1993 |
A mild case of nesidioblastosis with diagnostic and therapeutic difficulty.
Topics: Combined Modality Therapy; Diazoxide; Female; Glucose; Glucose Tolerance Test; Humans; Infant Food; | 1993 |
The enigma of persistent hyperinsulinemic hypoglycemia of infancy.
Topics: Diazoxide; Glucagon; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, Newborn; Octreo | 1993 |
Persistent hyperinsulinemic hypoglycemia of infancy: long-term octreotide treatment without pancreatectomy.
Topics: Diazoxide; Female; Follow-Up Studies; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Male; | 1993 |
Glucosamine-induced beta-cell dysfunction: a possible involvement of glucokinase or glucose-transporter type 2.
Topics: Animals; Arginine; Cells, Cultured; Diazoxide; Female; Gene Expression; Glucokinase; Glucosamine; Gl | 2002 |
[Hypoglycaemia (author's transl)].
Topics: Alcoholism; Diazoxide; Endocrine System Diseases; Enzymes; Glucose; Humans; Hydrocortisone; Hypoglyc | 1976 |
Medical treatment of endogenous organic hyperinsulinism.
Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Child; Chlorpromazine; Diazoxide; Female; Humans; Hyperin | 1976 |
[The insulinomas].
Topics: Adenoma, Islet Cell; Diazoxide; Glucagon; Humans; Hyperplasia; Insulin; Insulin Secretion; Pancreati | 1979 |
Paradoxical enhancement of tolbutamide-induced insulin release by diazoxide in a patient with islet cell hyperplasia.
Topics: Blood Glucose; Child; Diazoxide; Glucagon; Glucose Tolerance Test; Humans; Hyperplasia; Hypoglycemia | 1978 |
Hyperinsulinemia, cardiomyopathy, and diazoxide therapy.
Topics: Adolescent; Cardiomyopathy, Hypertrophic; Diazoxide; Humans; Insulin; Pancreatic Diseases | 1992 |
Surgical management of islet cell dysmaturation syndrome in young children.
Topics: Adenoma; Combined Modality Therapy; Diazoxide; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; I | 1990 |
Hyperinsulinism in infancy.
Topics: Diazoxide; Diuretics; Female; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Male; Pancreas | 1989 |
Long-term treatment with diazoxide in childhood hyperinsulinism.
Topics: Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, Newborn; Intellectual Disability; | 1986 |
Management of postoperative nesidioblastosis with zinc protamine glucagon and oral starch.
Topics: Administration, Oral; Child; Diazoxide; Drug Combinations; Female; Glucagon; Humans; Leucine; Pancre | 1986 |
Complications of diazoxide in the treatment of nesidioblastosis.
Topics: Ataxia; Diazoxide; Heart Failure; Humans; Infant; Infant, Newborn; Male; Pancreatic Diseases | 1985 |
Complications of diazoxide in the treatment of nesidioblastosis.
Topics: Diazoxide; Female; Heart Failure; Humans; Infant, Newborn; Pancreatic Diseases | 1985 |
Hypoglycemia due to organic hyperinsulinism in infancy.
Topics: Adenoma, Islet Cell; Adrenal Cortex Hormones; Diazoxide; Female; Humans; Hyperinsulinism; Hyperplasi | 1970 |
[Control of ATP levels in stimulated pancreatic B-cells].
Topics: Adenosine Triphosphate; Animals; Butyrates; Carbutamide; Cyclic AMP; Diazoxide; Epinephrine; Glucago | 1969 |
A-cell deficiency and B-cell hyperplasia of Langerhans' islet as a cause of leucine sensitive hypoglycemia.
Topics: Blood Glucose; Diazoxide; Epinephrine; Glucose Tolerance Test; Humans; Hyperplasia; Hypoglycemia; In | 1968 |
[Hyperglycemic and insulin-depressing effect of diazoxide in a case of hyperinsulinism caused by beta-insular hyperplasia].
Topics: Aged; Blood Glucose; Diazoxide; Female; Humans; Hyperplasia; Hypoglycemia; Insulin; Insulin Secretio | 1971 |
[Disorders of carbohydrate metabolism following diuretically effective agents].
Topics: Arteriosclerosis; Carbohydrate Metabolism; Chlorothiazide; Diabetes Mellitus; Diazoxide; Furosemide; | 1967 |
[Can organic hypoglycemia in adults be medically treated?].
Topics: Adrenal Cortex Hormones; Adult; Age Factors; Diazoxide; Diet Therapy; Drug Synergism; Hormones; Huma | 1968 |