diazoxide has been researched along with Orphan Diseases in 1 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Orphan Diseases: Rare diseases that have not been well studied.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rare forms of congenital hyperinsulinism (CHI) are caused by mutations in GLUD1 (encoding glutamate dehydrogenase), GCK (encoding glucokinase), HADH (encoding for L-3-hydroxyacyl-CoA dehydrogenase), SLC16A1 (encoding the monocarboxylat transporter 1), HNF4A (encoding hepatocyte nuclear factor 4α) or UCP2 (encoding mitochondrial uncoupling protein 2)." | 2.47 | Rare forms of congenital hyperinsulinism. ( Marquard, J; Mayatepek, E; Meissner, T; Palladino, AA; Stanley, CA, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marquard, J | 1 |
| Palladino, AA | 1 |
| Stanley, CA | 1 |
| Mayatepek, E | 1 |
| Meissner, T | 1 |
1 review available for diazoxide and Orphan Diseases
| Article | Year |
|---|---|
Rare forms of congenital hyperinsulinism.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Congenital Hyperinsulinism; Diazoxide; Glucokinase; Glutamate Dehy | 2011 |