diazoxide has been researched along with Myocardial Ischemia in 61 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twelve pigs were randomized to global ischemia for 2 hours with a single dose of cold blood (4:1) hyperkalemic cardioplegia alone (n = 6) or with diazoxide (500 μmol/L) (n = 6) and reperfused for 1 hour." | 8.12 | Diazoxide preserves myocardial function in a swine model of hypothermic cardioplegic arrest and prolonged global ischemia. ( Brady, MB; Cho, BC; Dodd-O, JM; Gaughan, N; Jones, M; Kearney, S; Lawton, JS; Lui, C; Metkus, TS; Suarez-Pierre, A; Thomas, RP; Wang, J; Zhou, X, 2022) |
| "Twelve pigs were randomized to global ischemia for 2 hours with a single dose of cold blood (4:1) hyperkalemic cardioplegia alone (n = 6) or with diazoxide (500 μmol/L) (n = 6) and reperfused for 1 hour." | 4.12 | Diazoxide preserves myocardial function in a swine model of hypothermic cardioplegic arrest and prolonged global ischemia. ( Brady, MB; Cho, BC; Dodd-O, JM; Gaughan, N; Jones, M; Kearney, S; Lawton, JS; Lui, C; Metkus, TS; Suarez-Pierre, A; Thomas, RP; Wang, J; Zhou, X, 2022) |
| " We explored the involvement of phosphatidylinositol 3-kinase (PI3K)/Akt in the PC-like effect of mitoKATP opener diazoxide with particular regard to its role in protection against ischaemia-induced arrhythmias." | 3.75 | Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms. ( Carnická, S; Kolár, F; Matejíková, J; Pancza, D; Ravingerová, T, 2009) |
| "Right atrial sections from four patient groups-non-diabetic, insulin-dependent diabetes mellitus (IDDM), non-insulin-dependent diabetes mellitus (NIDDM) receiving glibenclamide, and NIDDM receiving metformin-were subjected to one of the following protocols: aerobic control, simulated ischemia/reoxygenation, ischemic preconditioning before ischemia, and pharmacological preconditioning with alpha 1 agonist phenylephrine, adenosine, the mito-K(ATP) channel opener diazoxide, the protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA), or the p38 mitogen-activated protein kinase (p38MAPK) activator anisomycin." | 3.73 | Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium. ( Fowler, A; Galiñanes, M; Hassouna, A; Loubani, M; Matata, BM; Standen, NB, 2006) |
| "Diazoxide has been identified over the past 50years to have a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia." | 2.49 | Multiplicity of effectors of the cardioprotective agent, diazoxide. ( Coetzee, WA, 2013) |
| "Glibenclamide (10 μM) terminated these arrhythmias and restored APDs to control values." | 1.37 | Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. ( Ambrosi, CM; Chang, R; Efimov, IR; Fedorov, VV; Glukhov, AV; Janks, D; Kostecki, G; Moazami, N; Nichols, CG; Schuessler, RB, 2011) |
| "In diazoxide- treated hearts, diazoxide (50 micromol/l) was applied 15 min before II." | 1.34 | Changes in rat myocardium associated with modulation of ischemic tolerance by diazoxide. ( Andelová, E; Barancík, M; Ravingerová, T; Simoncíková, P; Tribulová, N, 2007) |
| "Diazoxide (DIAZ) has been shown to be neuroprotective in animal models of different brain pathologies." | 1.34 | Diazoxide is protective in the rat retina against ischemic injury induced by bilateral carotid occlusion and glutamate-induced degeneration. ( Atlasz, T; Babai, N; Bari, F; Domoki, F; Gabriel, R; Kiss, P; Reglodi, D; Tamas, A, 2007) |
| " Therefore, pharmacological preconditioning with diazoxide in combination with adenosine and a nitric oxide donor (triple-combination pharmacological preconditioning) may enhance cardioprotection." | 1.32 | Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor. ( Imamura, H; Kido, M; Nakao, S; Ninomiya, H; Okada, T; Otani, H; Shingu, K; Uchiyama, T; Uchiyama, Y, 2003) |
| "Glimepiride (Glim) is a new sulfonylurea reported to affect nonpancreatic K(ATP) channels less than does Glib." | 1.31 | Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide. ( Baxter, GF; Lawrence, CL; Maddock, HL; Mocanu, MM; Standen, NB; Yellon, DM, 2001) |
| "Diazoxide pretreatment significantly improved the recovery of LV function and coronary flow compared to control (LVDP: 49 +/- 5* vs." | 1.31 | Diazoxide protects the rabbit heart following cardioplegic ischemia. ( Feng, J; Li, H; Rosenkranz, ER, 2002) |
| "Diazoxide (1 mg/kg) was administered either 30 min (for EP) or 24 h (DP) before 30 min of lethal ischemia." | 1.30 | Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide. ( Brown, M; Emani, VR; Krottapalli, K; Kukreja, RC; Ockaili, R; Okubo, S, 1999) |
| "Pretreatment with diazoxide (10 mg." | 1.29 | Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats. ( Ichihara, K; Nakai, T, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (8.20) | 18.2507 |
| 2000's | 51 (83.61) | 29.6817 |
| 2010's | 4 (6.56) | 24.3611 |
| 2020's | 1 (1.64) | 2.80 |
| Authors | Studies |
|---|---|
| Coghlan, MJ | 1 |
| Carroll, WA | 1 |
| Gopalakrishnan, M | 1 |
| Breschi, MC | 2 |
| Calderone, V | 3 |
| Digiacomo, M | 3 |
| Manganaro, M | 2 |
| Martelli, A | 3 |
| Minutolo, F | 1 |
| Rapposelli, S | 3 |
| Testai, L | 3 |
| Tonelli, F | 1 |
| Balsamo, A | 2 |
| Cirilli, R | 1 |
| Faggi, C | 1 |
| La Torre, F | 1 |
| Vanni, M | 1 |
| Suarez-Pierre, A | 1 |
| Lui, C | 1 |
| Zhou, X | 1 |
| Kearney, S | 1 |
| Jones, M | 1 |
| Wang, J | 2 |
| Thomas, RP | 1 |
| Gaughan, N | 1 |
| Metkus, TS | 1 |
| Brady, MB | 1 |
| Cho, BC | 1 |
| Dodd-O, JM | 1 |
| Lawton, JS | 3 |
| Coetzee, WA | 1 |
| Janjua, MB | 1 |
| Makepeace, CM | 1 |
| Anastacio, MM | 1 |
| Schuessler, RB | 3 |
| Nichols, CG | 2 |
| Srisakuldee, W | 1 |
| Jeyaraman, MM | 1 |
| Nickel, BE | 1 |
| Tanguy, S | 1 |
| Jiang, ZS | 1 |
| Kardami, E | 1 |
| Matejíková, J | 1 |
| Ravingerová, T | 2 |
| Pancza, D | 1 |
| Carnická, S | 1 |
| Kolár, F | 1 |
| Cao, H | 1 |
| Chen, XX | 1 |
| Gui, B | 1 |
| Duan, SM | 1 |
| Zeng, YM | 1 |
| Fedorov, VV | 1 |
| Glukhov, AV | 1 |
| Ambrosi, CM | 1 |
| Kostecki, G | 1 |
| Chang, R | 1 |
| Janks, D | 1 |
| Moazami, N | 1 |
| Efimov, IR | 1 |
| Hausenloy, DJ | 2 |
| Maddock, HL | 2 |
| Baxter, GF | 2 |
| Yellon, DM | 4 |
| Peart, J | 1 |
| Willems, L | 1 |
| Headrick, JP | 1 |
| Legtenberg, RJ | 1 |
| Rongen, GA | 1 |
| Houston, RJ | 1 |
| Oeseburg, B | 1 |
| Smits, P | 1 |
| Lim, KH | 1 |
| Javadov, SA | 1 |
| Das, M | 1 |
| Clarke, SJ | 1 |
| Suleiman, MS | 1 |
| Halestrap, AP | 1 |
| Suzuki, M | 1 |
| Saito, T | 1 |
| Sato, T | 3 |
| Tamagawa, M | 1 |
| Miki, T | 3 |
| Seino, S | 1 |
| Nakaya, H | 1 |
| Korge, P | 1 |
| Honda, HM | 1 |
| Weiss, JN | 1 |
| Uchiyama, Y | 1 |
| Otani, H | 1 |
| Okada, T | 1 |
| Uchiyama, T | 1 |
| Ninomiya, H | 1 |
| Kido, M | 1 |
| Imamura, H | 1 |
| Nakao, S | 1 |
| Shingu, K | 1 |
| Oldenburg, O | 1 |
| Yang, XM | 1 |
| Krieg, T | 1 |
| Garlid, KD | 2 |
| Cohen, MV | 1 |
| Grover, GJ | 1 |
| Downey, JM | 1 |
| McCully, JD | 4 |
| Levitsky, S | 4 |
| Wakahara, N | 1 |
| Katoh, H | 1 |
| Yaguchi, Y | 1 |
| Uehara, A | 1 |
| Satoh, H | 1 |
| Terada, H | 1 |
| Fujise, Y | 1 |
| Hayashi, H | 1 |
| Loubani, M | 2 |
| Hassouna, A | 2 |
| Galiñanes, M | 3 |
| O'Rourke, B | 4 |
| Hausenloy, D | 1 |
| Wynne, A | 1 |
| Duchen, M | 1 |
| Yellon, D | 1 |
| Wang, Y | 4 |
| Ahmad, N | 2 |
| Kudo, M | 1 |
| Ashraf, M | 4 |
| Wei, K | 1 |
| Min, S | 1 |
| Long, C | 1 |
| Harada, N | 1 |
| Miura, T | 3 |
| Dairaku, Y | 1 |
| Kametani, R | 1 |
| Shibuya, M | 1 |
| Wang, R | 1 |
| Kawamura, S | 1 |
| Matsuzaki, M | 1 |
| Beresewicz, A | 1 |
| Maczewski, M | 1 |
| Duda, M | 1 |
| Rousou, AJ | 2 |
| Ericsson, M | 1 |
| Federman, M | 1 |
| Er, F | 1 |
| Michels, G | 1 |
| Gassanov, N | 1 |
| Rivero, F | 1 |
| Hoppe, UC | 1 |
| Kristiansen, SB | 1 |
| Nielsen-Kudsk, JE | 1 |
| Bøtker, HE | 1 |
| Nielsen, TT | 1 |
| Matata, BM | 1 |
| Fowler, A | 1 |
| Standen, NB | 3 |
| Naitoh, K | 1 |
| Ichikawa, Y | 1 |
| Nakamura, Y | 1 |
| Ikeda, Y | 1 |
| Kobayashi, H | 1 |
| Nishihara, M | 1 |
| Ohori, K | 1 |
| Shimamoto, K | 2 |
| Haider, KH | 1 |
| Wang, B | 1 |
| Pasha, Z | 1 |
| Uzun, O | 1 |
| Toyoda, Y | 2 |
| Wakiyama, H | 1 |
| Parker, RA | 1 |
| Pasdois, P | 1 |
| Beauvoit, B | 1 |
| Tariosse, L | 2 |
| Vinassa, B | 1 |
| Bonoron-Adèle, S | 1 |
| Santos, PD | 1 |
| Gao, H | 1 |
| Chen, L | 1 |
| Yang, HT | 1 |
| Lim, SY | 1 |
| Davidson, SM | 1 |
| Schulz, R | 1 |
| Boengler, K | 1 |
| Totzeck, A | 1 |
| Luo, Y | 1 |
| Garcia-Dorado, D | 1 |
| Heusch, G | 1 |
| Simoncíková, P | 1 |
| Andelová, E | 1 |
| Tribulová, N | 1 |
| Barancík, M | 1 |
| Al-Dadah, AS | 1 |
| Voeller, RK | 1 |
| Damiano, RJ | 1 |
| Rosenkranz, ER | 2 |
| Atlasz, T | 1 |
| Babai, N | 1 |
| Reglodi, D | 1 |
| Kiss, P | 1 |
| Tamas, A | 1 |
| Bari, F | 1 |
| Domoki, F | 1 |
| Gabriel, R | 1 |
| Nakai, T | 1 |
| Ichihara, K | 1 |
| Liu, Y | 2 |
| Marban, E | 3 |
| Seharaseyon, J | 1 |
| Szewczyk, A | 1 |
| Ockaili, R | 1 |
| Emani, VR | 1 |
| Okubo, S | 1 |
| Brown, M | 1 |
| Krottapalli, K | 1 |
| Kukreja, RC | 1 |
| Iwai, T | 1 |
| Tanonaka, K | 1 |
| Koshimizu, M | 1 |
| Takeo, S | 1 |
| Ghosh, S | 1 |
| Pomerantz, BJ | 1 |
| Robinson, TN | 1 |
| Morrell, TD | 1 |
| Heimbach, JK | 1 |
| Banerjee, A | 1 |
| Harken, AH | 1 |
| Kevelaitis, E | 1 |
| Oubénaissa, A | 1 |
| Mouas, C | 1 |
| Peynet, J | 1 |
| Menasché, P | 1 |
| Imahashi, K | 1 |
| Nishimura, T | 1 |
| Yoshioka, J | 1 |
| Kusuoka, H | 1 |
| Mocanu, MM | 1 |
| Lawrence, CL | 1 |
| Takashi, E | 1 |
| Xu, M | 1 |
| Ayub, A | 1 |
| Schulman, D | 1 |
| Latchman, DS | 1 |
| Murata, M | 1 |
| Akao, M | 1 |
| Dos Santos, P | 1 |
| Kowaltowski, AJ | 1 |
| Laclau, MN | 1 |
| Seetharaman, S | 1 |
| Paucek, P | 1 |
| Boudina, S | 1 |
| Thambo, JB | 1 |
| Ohnuma, Y | 1 |
| Tanno, M | 1 |
| Kuno, A | 1 |
| Tsuchida, A | 1 |
| Feng, J | 1 |
| Li, H | 1 |
6 reviews available for diazoxide and Myocardial Ischemia
| Article | Year |
|---|---|
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
Topics: Adenosine Triphosphate; Angina Pectoris; Arrhythmias, Cardiac; Asthma; Calcium; Ion Channel Gating; | 2001 |
Multiplicity of effectors of the cardioprotective agent, diazoxide.
Topics: Animals; Cardiotonic Agents; Diazoxide; Humans; Insulin-Secreting Cells; KATP Channels; Mitochondria | 2013 |
Mitochondrial ATP-sensitive potassium channels in surgical cardioprotection.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cardiotonic Agents; Diazoxide; Disease Models, Animal; H | 2003 |
Evidence for mitochondrial K+ channels and their role in cardioprotection.
Topics: Adenosine; Animals; Cattle; Diazoxide; Energy Metabolism; Humans; Ion Transport; Ischemic Preconditi | 2004 |
Connexin 43 in ischemic pre- and postconditioning.
Topics: Connexin 43; Diazoxide; Humans; Ischemic Preconditioning, Myocardial; Mitochondria; Mitochondrial Me | 2007 |
Mitochondrial ATP-dependent potassium channels. Viable candidate effectors of ischemic preconditioning.
Topics: Animals; Decanoic Acids; Diazoxide; Heart; Hydroxy Acids; Intracellular Membranes; Ischemic Precondi | 1999 |
55 other studies available for diazoxide and Myocardial Ischemia
| Article | Year |
|---|---|
Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel.
Topics: Animals; Benzopyrans; Blood Pressure; KATP Channels; Male; Mitochondria; Molecular Structure; Myocar | 2008 |
Enantioselectivity in cardioprotection induced by (S)- (-)-2,2-dimethyl-N-(4'-acetamido-benzyl)-4-spiromorpholone-chromane.
Topics: Animals; Benzopyrans; Cardiotonic Agents; Chromatography, High Pressure Liquid; Circular Dichroism; | 2009 |
Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia.
Topics: Animals; Benzopyrans; Cardiotonic Agents; Cell Line; KATP Channels; Male; Myocardial Ischemia; Myocy | 2011 |
Diazoxide preserves myocardial function in a swine model of hypothermic cardioplegic arrest and prolonged global ischemia.
Topics: Adenosine Triphosphate; Animals; Cardioplegic Solutions; Diazoxide; Heart Arrest, Induced; Ischemia; | 2022 |
Cardioprotective benefits of adenosine triphosphate-sensitive potassium channel opener diazoxide are lost with administration after the onset of stress in mouse and human myocytes.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Diazoxide; Disease Models, Animal; Female; Heart A | 2014 |
Phosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resistant state.
Topics: Amino Acid Substitution; Animals; Connexin 43; Diazoxide; Fibroblast Growth Factor 2; Gene Expressio | 2009 |
Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms.
Topics: Androstadienes; Animals; Arrhythmias, Cardiac; Diazoxide; Mitochondria, Heart; Myocardial Ischemia; | 2009 |
[The effects of diazoxide on myocardium function and the expressions of ERK and JNK in isolated spontaneous hypertension rat hearts].
Topics: Animals; Diazoxide; In Vitro Techniques; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Myo | 2006 |
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.
Topics: Action Potentials; Adolescent; Adult; Arrhythmias, Cardiac; Coronary Vessels; Diazoxide; Female; Gen | 2011 |
Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?
Topics: Adenosine; Analysis of Variance; Animals; Atractyloside; Calcineurin Inhibitors; Cyclosporine; Decan | 2002 |
Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine.
Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; Cardiotonic Agents; Diazoxide; Drug Ad | 2003 |
The role of myocardial KATP-channel blockade in the protective effects of glibenclamide against ischaemia in the rat heart.
Topics: Animals; Coronary Circulation; Diazoxide; Drug Interactions; Glyburide; Male; Myocardial Ischemia; P | 2002 |
The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration.
Topics: Acyl Coenzyme A; Animals; Decanoic Acids; Diazoxide; Heart; Hydroxy Acids; Ischemic Preconditioning, | 2002 |
Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzamides; Cardiotonic Agents; Diazoxide; In Vi | 2003 |
Effects of fatty acids in isolated mitochondria: implications for ischemic injury and cardioprotection.
Topics: Adenosine Triphosphate; Animals; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell M | 2003 |
Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor.
Topics: Adenosine; Animals; Combined Modality Therapy; Coronary Circulation; Creatine Kinase; Diazoxide; Dis | 2003 |
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
Topics: Animals; Brain Chemistry; Decanoic Acids; Diazoxide; Glyburide; Guanidines; Hydroxy Acids; Ischemic | 2003 |
Difference in the cardioprotective mechanisms between ischemic preconditioning and pharmacological preconditioning by diazoxide in rat hearts.
Topics: Animals; ATP-Binding Cassette Transporters; Cardiotonic Agents; Diazoxide; Energy Metabolism; Hydrog | 2004 |
Delayed preconditioning of the human myocardium: signal transduction and clinical implications.
Topics: Acetylcholine; Aged; Alkaloids; Anisomycin; Antihypertensive Agents; Benzophenanthridines; Culture T | 2004 |
Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection.
Topics: 2,4-Dinitrophenol; Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Anima | 2004 |
Contribution of Akt and endothelial nitric oxide synthase to diazoxide-induced late preconditioning.
Topics: Animals; Apoptosis; Coronary Circulation; Diazoxide; Hemodynamics; Ischemic Preconditioning, Myocard | 2004 |
Cardioprotective effects of mitochondrial KATP channels activated at different time.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Female; Ischemic Preconditioning, Myocardial; Male; Memb | 2004 |
NO donor-activated PKC-delta plays a pivotal role in ischemic myocardial protection through accelerated opening of mitochondrial K-ATP channels.
Topics: Animals; Antihypertensive Agents; Diazoxide; Enzyme Activation; Heart Rate; Isoenzymes; Membrane Pro | 2004 |
Effect of classic preconditioning and diazoxide on endothelial function and O2- and NO generation in the post-ischemic guinea-pig heart.
Topics: Animals; Benzamides; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Endothelium, Vascu | 2004 |
Opening of mitochondrial KATP channels enhances cardioprotection through the modulation of mitochondrial matrix volume, calcium accumulation, and respiration.
Topics: Adenosine Triphosphate; Animals; Calcium; Cardioplegic Solutions; Cardiotonic Agents; Diazoxide; Dru | 2004 |
Testosterone induces cytoprotection by activating ATP-sensitive K+ channels in the cardiac mitochondrial inner membrane.
Topics: Adenosine Triphosphate; Androgen Receptor Antagonists; Androstenedione; Animals; Biological Transpor | 2004 |
Effects of KATP channel modulation on myocardial glycogen content, lactate, and amino acids in nonischemic and ischemic rat hearts.
Topics: Alanine; Amino Acids; Animals; Diazoxide; Drug Interactions; Glutamic Acid; Glyburide; Glycogen; Lac | 2005 |
Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium.
Topics: Adenosine; Adrenergic alpha-Agonists; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitu | 2006 |
MitoKATP channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Cell Membrane Permeability; Connexin 43; Diazoxide; Enzyme Inhibito | 2006 |
Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning.
Topics: Androstadienes; Animals; Apoptosis; Benzopyrans; Blotting, Western; Cardiotonic Agents; Cytosol; Dia | 2006 |
Age- and gender-related differences in ischemia/reperfusion injury and cardioprotection: effects of diazoxide.
Topics: Aging; Animals; Cardioplegic Solutions; Cardiotonic Agents; Cerebral Infarction; Diazoxide; Disease | 2006 |
MitoK(ATP)-dependent changes in mitochondrial volume and in complex II activity during ischemic and pharmacological preconditioning of Langendorff-perfused rat heart.
Topics: Adenosine Diphosphate; Animals; Antihypertensive Agents; Cell Respiration; Decanoic Acids; Diazoxide | 2006 |
Activation of alpha1B-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca2+ overload in cardiomyocytes.
Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Anima | 2007 |
Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore.
Topics: Animals; Bradykinin; Cyclophilins; Cyclosporine; Diazoxide; Enzyme Inhibitors; Female; Ischemic Prec | 2007 |
Changes in rat myocardium associated with modulation of ischemic tolerance by diazoxide.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Diazoxide; Enzyme Activation; Extracellular Signal | 2007 |
Maintenance of myocyte volume homeostasis during stress by diazoxide is cardioprotective.
Topics: Adenosine Triphosphate; Animals; Calcium; Cardiac Volume; Diazoxide; Female; Homeostasis; Male; Myoc | 2007 |
Invited commentary.
Topics: Animals; Diazoxide; Myocardial Contraction; Myocardial Ischemia; Myocytes, Cardiac; Potassium Channe | 2007 |
Diazoxide is protective in the rat retina against ischemic injury induced by bilateral carotid occlusion and glutamate-induced degeneration.
Topics: Animals; Animals, Newborn; Cell Count; Diazoxide; Disease Models, Animal; Drug Interactions; Glutami | 2007 |
Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Calcium; Diazoxide; Disease Models, Animal; Dose-Res | 1994 |
Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection?
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Diazoxide; Flavoproteins; Fluorescence; Heart Vent | 1998 |
Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca2+ overload injury in rat myocardium.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium; Calcium Channel Blockers; | 1999 |
Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Coronary Vessels; Decanoic Acids; Diazoxide | 1999 |
Preservation of mitochondrial function by diazoxide during sustained ischaemia in the rat heart.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Creatine Kinase; Diazoxide; Diuretics; Energy | 2000 |
Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning.
Topics: Analysis of Variance; Cell Membrane; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Gl | 2000 |
Selective mitochondrial adenosine triphosphate-sensitive potassium channel activation is sufficient to precondition human myocardium.
Topics: Adenosine; Adenosine Triphosphate; Analysis of Variance; Creatine Kinase; Diazoxide; Humans; Mitocho | 2000 |
Ischemic preconditioning with opening of mitochondrial adenosine triphosphate-sensitive potassium channels or Na/H exchange inhibition: which is the best protective strategy for heart transplants?
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Creatine Kinase; Diaz | 2001 |
Opening of mitochondrial ATP-sensitive potassium channels enhances cardioplegic protection.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Cardioplegic Solutions; Diazoxide; Disease Mo | 2001 |
Role of intracellular Na(+) kinetics in preconditioned rat heart.
Topics: Animals; Decanoic Acids; Diazoxide; Hydroxy Acids; In Vitro Techniques; Intracellular Fluid; Ischemi | 2001 |
Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide.
Topics: Animals; Diazoxide; Glyburide; Guanosine Triphosphate; Heart; Heart Ventricles; Hemodynamics; Hypogl | 2001 |
Downregulation of protein kinase C inhibits activation of mitochondrial K(ATP) channels by diazoxide.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Dose-Response Relationship, Drug; Down-Regulation; Immun | 2001 |
Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.
Topics: Adenosine; Aging; Animals; Diazoxide; Diglycerides; Heart; Ischemic Preconditioning, Myocardial; Mal | 2001 |
Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection.
Topics: Bongkrekic Acid; Calcium; Cell Separation; Cytoprotection; Decanoic Acids; Diazoxide; Dose-Response | 2001 |
Mechanisms by which opening the mitochondrial ATP- sensitive K(+) channel protects the ischemic heart.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Respiration; Creatine; Diazoxide; Hemod | 2002 |
Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Diazoxide; Enzyme Activation; Hemodynamics; Hydroxy | 2002 |
Diazoxide protects the rabbit heart following cardioplegic ischemia.
Topics: Animals; Anti-Arrhythmia Agents; Cardioplegic Solutions; Coronary Circulation; Decanoic Acids; Diast | 2002 |