diazoxide has been researched along with Muscle Contraction in 42 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Diazoxide (Dia) and Min were found to inhibit antigen-induced guinea-pig ileum smooth muscle contraction in vitro." | 3.69 | [The anti-anaphylactic action of potassium channel openers and its mechanism]. ( Wang, P; Wei, EQ; Xu, JH, 1997) |
| "Partial bladder outlet obstruction of the pig is considered as a valuable preclinical model for evaluating the profile of compounds for the treatment of bladder overactivity." | 1.33 | Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs. ( Brune, ME; Buckner, SA; Coghlan, M; Daza, A; Fey, TA; Gopalakrishnan, M; Milicic, I, 2006) |
| "Pretreatment with diazoxide (10 mg." | 1.29 | Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats. ( Ichihara, K; Nakai, T, 1994) |
| " Dose-response curves to Ba2+ in SHR strips were displaced to the right as compared to NW rats." | 1.26 | Evidence for a visceral smooth muscle abnormality in Okamoto spontaneous hypertension. ( Altman, J; Da Ponte, F; Worcel, M, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (45.24) | 18.7374 |
| 1990's | 9 (21.43) | 18.2507 |
| 2000's | 10 (23.81) | 29.6817 |
| 2010's | 4 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Tullio, P | 8 |
| Pirotte, B | 8 |
| Lebrun, P | 10 |
| Fontaine, J | 5 |
| Dupont, L | 3 |
| Antoine, MH | 6 |
| Ouedraogo, R | 5 |
| Khelili, S | 3 |
| Maggetto, C | 1 |
| Masereel, B | 1 |
| Diouf, O | 1 |
| Podona, T | 1 |
| Delarge, J | 2 |
| Somers, F | 4 |
| Boverie, S | 5 |
| Damas, J | 2 |
| Becker, B | 4 |
| Rigo, B | 1 |
| Nielsen, FE | 1 |
| Bodvarsdottir, TB | 1 |
| Worsaae, A | 1 |
| MacKay, P | 1 |
| Stidsen, CE | 1 |
| Boonen, HC | 1 |
| Pridal, L | 1 |
| Arkhammar, PO | 1 |
| Wahl, P | 1 |
| Ynddal, L | 1 |
| Junager, F | 1 |
| Dragsted, N | 1 |
| Tagmose, TM | 1 |
| Mogensen, JP | 1 |
| Koch, A | 1 |
| Treppendahl, SP | 1 |
| Hansen, JB | 1 |
| Sebille, S | 2 |
| Counerotte, S | 2 |
| Nguyen, QA | 1 |
| Francotte, P | 1 |
| Michaux, C | 1 |
| Florence, X | 1 |
| Desvaux, V | 1 |
| Goffin, E | 1 |
| Bouhedja, M | 1 |
| Peres, B | 1 |
| Fhayli, W | 1 |
| Ghandour, Z | 1 |
| Boumendjel, A | 1 |
| Faury, G | 1 |
| Shimbo, T | 1 |
| Adachi, T | 1 |
| Fujisawa, S | 1 |
| Hongoh, M | 1 |
| Ohba, T | 1 |
| Ono, K | 1 |
| Li, X | 1 |
| Mizuno, R | 1 |
| Ono, N | 1 |
| Ohhashi, T | 1 |
| Nakayama, S | 1 |
| Ohya, S | 1 |
| Liu, HN | 1 |
| Watanabe, T | 1 |
| Furuzono, S | 1 |
| Wang, J | 1 |
| Nishizawa, Y | 1 |
| Aoyama, M | 1 |
| Murase, N | 1 |
| Matsubara, T | 1 |
| Ito, Y | 1 |
| Imaizumi, Y | 1 |
| Kajioka, S | 1 |
| Milicic, I | 1 |
| Buckner, SA | 1 |
| Daza, A | 1 |
| Coghlan, M | 1 |
| Fey, TA | 1 |
| Brune, ME | 1 |
| Gopalakrishnan, M | 1 |
| Clemente, CM | 1 |
| Araújo, PV | 1 |
| Palheta, RC | 1 |
| Ratts, ZM | 1 |
| Fernandes, GH | 1 |
| Rola, FH | 1 |
| de Oliveira, RB | 1 |
| dos Santos, AA | 1 |
| Magalhães, PJ | 1 |
| Wohl, AJ | 1 |
| Hausler, LM | 1 |
| Roth, FE | 1 |
| Estrada, C | 1 |
| Conde, MV | 1 |
| Balfagón, G | 1 |
| Gómez, B | 1 |
| Lluch, S | 1 |
| Albrecht, T | 1 |
| Speelman, DJ | 1 |
| Steinsland, OS | 1 |
| Abrahams, Z | 1 |
| Sutter, MC | 2 |
| Nakai, T | 1 |
| Ichihara, K | 1 |
| Kageyama, M | 1 |
| Shirasawa, E | 1 |
| Velasco, A | 1 |
| Maroto, M | 1 |
| Dueñas, A | 1 |
| Carvajal, A | 1 |
| Fernández de la Gándara, F | 1 |
| Nieto, A | 1 |
| Mahmoudian, M | 1 |
| Mirkhani, H | 1 |
| Wang, P | 1 |
| Xu, JH | 1 |
| Wei, EQ | 1 |
| Janis, RA | 2 |
| Diamond, J | 1 |
| Altman, J | 1 |
| Da Ponte, F | 1 |
| Worcel, M | 1 |
| Chona, S | 1 |
| Triggle, DJ | 3 |
| Levy, JV | 1 |
| Berkenboom, G | 1 |
| Fang, ZY | 1 |
| Herchuelz, A | 1 |
| Irion, GL | 1 |
| Vasthare, US | 1 |
| Tuma, RF | 1 |
| Stower, MJ | 1 |
| Clark, AG | 1 |
| Wright, JW | 1 |
| Hardcastle, JD | 1 |
| Wilson, KH | 4 |
| Lauersen, NH | 1 |
| Raghavan, KS | 1 |
| Fuchs, F | 2 |
| Niemann, WH | 1 |
| Landesman, R | 4 |
| Wilkenfeld, BE | 1 |
| Levy, B | 1 |
| Polacek, I | 1 |
| Bolan, J | 1 |
| Daniel, EE | 1 |
| Swamy, VC | 1 |
| Rhodes, HJ | 1 |
| Coutinho, EM | 2 |
| Lopes, AC | 1 |
| de Souza, JA | 1 |
| de Sousa, MB | 1 |
1 review available for diazoxide and Muscle Contraction
| Article | Year |
|---|---|
Control of uterine activity and prevention of premature birth.
Topics: Adrenergic beta-Antagonists; Aspirin; Blood Pressure; Diazoxide; Epinephrine; Ethanol; Female; Fetal | 1974 |
41 other studies available for diazoxide and Muscle Contraction
| Article | Year |
|---|---|
3-and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation, and structure-activity relationships.
Topics: Animals; Aorta; Diazoxide; Female; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; | 1996 |
3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis, and pharmacological evaluation.
Topics: Animals; Aorta; Cyclic S-Oxides; Diazoxide; Drug Design; Female; Guinea Pigs; Ileum; In Vitro Techni | 2000 |
Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and K(ATP) channel activity.
Topics: Adenosine Triphosphate; Animals; Aorta; Calcium; Crystallography, X-Ray; Female; Glyburide; Guinea P | 2001 |
6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Binding, Competitive; Biological | 2002 |
Effect on K(ATP) channel activation properties and tissue selectivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides.
Topics: Adenosine Triphosphate; Animals; Aorta; Benzothiadiazines; In Vitro Techniques; Insulin; Insulin Sec | 2005 |
3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.
Topics: Adenosine Triphosphate; Animals; Aorta; Benzothiadiazines; Cyclic S-Oxides; In Vitro Techniques; Ins | 2005 |
Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.
Topics: Animals; Aorta; Benzothiadiazines; Diazoxide; Female; Hydrogen Bonding; Hydrogen-Ion Concentration; | 2011 |
Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: from potassium channel openers to calcium entry blockers?
Topics: Animals; Aorta; Biological Transport; Calcium; Chromans; Cromakalim; Dose-Response Relationship, Dru | 2014 |
Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis.
Topics: Animals; Cromakalim; Dose-Response Relationship, Drug; Drug Design; Elastin; Female; Molecular Struc | 2018 |
In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat.
Topics: Animals; Carbachol; Diazoxide; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Glybur | 2016 |
Glucose and glucose transporters regulate lymphatic pump activity through activation of the mitochondrial ATP-sensitive K+ channel.
Topics: Animals; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Chlorogenic Acid; Cytochalasin | 2008 |
2-alkyl-3-Alkylamino-2H-Benzo- and pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers?
Topics: Alkanes; Animals; Aorta, Thoracic; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Diaz | 2002 |
Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractility.
Topics: Animals; ATP-Binding Cassette Transporters; Base Sequence; Calcium; Calcium Channels; Cells, Culture | 2005 |
Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Carbachol; Cholinergic Agonists; Cromakalim; | 2006 |
Sildenafil inhibits duodenal contractility via activation of the NO-K+ channel pathway.
Topics: Animals; Colforsin; Diazoxide; Duodenum; In Vitro Techniques; Male; Muscle Contraction; NG-Nitroargi | 2008 |
Studies on the mechanism of antihypertensive action of diazoxide: in vitro vascular pharmacodynamics.
Topics: Animals; Aorta; Barium; Blood Pressure; Calcium; Diazoxide; Drug Antagonism; In Vitro Techniques; Mu | 1967 |
Relaxation of isolated middle cerebral artery induced by diazoxide.
Topics: Animals; Antihypertensive Agents; Cerebral Arteries; Diazoxide; Dose-Response Relationship, Drug; El | 1981 |
Similarities between cytomegalovirus-induced cell rounding and contraction of smooth muscle cells.
Topics: Cytomegalovirus; Cytomegalovirus Infections; Cytopathogenic Effect, Viral; Diazoxide; Fibroblasts; H | 1983 |
Effects of K+ channel openers on the vascular actions of human gamma globulin.
Topics: Animals; Diazoxide; gamma-Globulins; Glyburide; Guanidines; Humans; In Vitro Techniques; Male; Muscl | 1994 |
Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Calcium; Diazoxide; Disease Models, Animal; Dose-Res | 1994 |
L-type voltage-dependent Ca2+ and ATP-sensitive K+ channels are not involved in the regulation of bovine ciliary muscle contractility.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Calcium; Calcium Channel Agonists; Calcium Channel | 1995 |
Effect of 4-aminopyridine and 3,4-diaminopyridine on guinea-pig isolated ileum.
Topics: 4-Aminopyridine; Acetylcholine; Amifampridine; Animals; Atropine; Calcium Channel Blockers; Diazoxid | 1997 |
Effect of diazoxide, an ATP-dependent potassium-channel opener, on isolated aortae of normal and diabetic rats.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Diabetes Mellitus, Experimental; Diazoxide; Glybu | 1998 |
[The anti-anaphylactic action of potassium channel openers and its mechanism].
Topics: Anaphylaxis; Animals; Capillary Permeability; Diazoxide; Female; Guinea Pigs; Histamine; In Vitro Te | 1997 |
Relationship between cyclic nucleotide levels and drug-induced relaxation of smooth muscle.
Topics: Animals; Cyclic AMP; Cyclic GMP; Diazoxide; Drug Interactions; Female; Guinea Pigs; Hydralazine; In | 1979 |
Evidence for a visceral smooth muscle abnormality in Okamoto spontaneous hypertension.
Topics: Animals; Barium; Calcium; Diazoxide; Female; Hypertension; In Vitro Techniques; Lanthanum; Male; Man | 1977 |
The action of diazoxide analogs on aortic reactivity in normotensive and spontaneously hypertensive rats.
Topics: Animals; Aorta, Thoracic; Benzothiadiazines; Blood Vessels; Diazoxide; Drug Interactions; Hypertensi | 1977 |
Verapamil and diazoxide antagonism of agonist-induced contractions of aortic strips from normal and spontaneously hypertensive rats (SHR).
Topics: Animals; Aorta, Thoracic; Diazoxide; Hypertension; In Vitro Techniques; Methoxamine; Muscle Contract | 1975 |
Mechanical and ionic response of rat aorta to diazoxide.
Topics: Animals; Aorta; Calcium; Calcium Radioisotopes; Diazoxide; Endothelium, Vascular; Hypoglycemia; Musc | 1992 |
Relaxation response to pinacidil and diazoxide in the mouse isolated distal colon.
Topics: Animals; Colon; Diazoxide; Dose-Response Relationship, Drug; Guanidines; Mice; Muscle Contraction; M | 1990 |
Age-related change in skeletal muscle blood flow in the rat.
Topics: Aging; Animals; Blood Flow Velocity; Diazoxide; Female; Hemodynamics; Male; Muscle Contraction; Musc | 1987 |
The effect of various drugs on canine ureteric peristalsis.
Topics: Animals; Colic; Diazoxide; Dogs; Drug Evaluation, Preclinical; Female; Muscle Contraction; Ritodrine | 1986 |
Effects of diazoxide and beta adrenergic drugs on spontaneous and induced uterine activity in the pregnant baboon.
Topics: Adrenergic beta-Agonists; Animals; Chemical Phenomena; Chemistry; Depression, Chemical; Diazoxide; D | 1974 |
The effects of theophylline, diazoxide and imidazole on isoproterenol-induced inhibition of the rabbit ileum.
Topics: Animals; Cyclic AMP; Diazoxide; Ileum; Imidazoles; In Vitro Techniques; Isoproterenol; Muscle Contra | 1969 |
Accumulation of adenosine 3',5'-monophosphate and relaxation in the rat uterus in vitro.
Topics: Animals; Butyrates; Cyclic AMP; Depression, Chemical; Diazoxide; Drug Interactions; Female; Fluoride | 1971 |
2-Halogenoethylamines and the role of Ca 2+ in adrenergic -receptor activation in the rat vas deferens.
Topics: Animals; Binding Sites; Bromine; Calcium; Diazoxide; Dibucaine; Drug Antagonism; Drug Interactions; | 1972 |
Effect of diazoxide on aortic reactivity to calcium in spontaneously hypertensive rats.
Topics: Animals; Aorta, Thoracic; Calcium; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; H | 1973 |
The action of diazoxide on isolated vascular smooth muscle electrophysiology and contraction.
Topics: Action Potentials; Animals; Calcium; Cell Membrane Permeability; Diazoxide; Electrophysiology; Femal | 1971 |
The relaxant effect of diazoxide on isolated gravid and nongravid human myometrium.
Topics: Diazoxide; Epinephrine; Female; Humans; In Vitro Techniques; Muscle Contraction; Muscles; Norepineph | 1968 |
The relaxant effect of diazoxide on nongravid human myometrium in vivo.
Topics: Catheterization; Diazoxide; Female; Humans; Hypertension; Injections, Intravenous; Menstruation; Mus | 1968 |
The inhibitory effect of diazoxide in normal term labor.
Topics: Blood Pressure; Diazoxide; Female; Fetal Heart; Heart Rate; Humans; Hypotension; Labor, Obstetric; M | 1969 |