diazoxide has been researched along with Kidney Failure, Chronic in 22 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia." | 7.81 | Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide. ( Aso, Y; Hiraishi, H; Kojima, M; Shimizu, M; Suzuki, K; Tsuchida, K, 2015) |
| "Treatment with oral diazoxide for periods of 4 to 10 weeks in hospital allowed adequate control of hypertension with continuation of fetal growth in four patients with severe toxaemia." | 7.65 | Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy. ( Davis, D; Morgan, MY; Pohl, JE; Thurston, H, 1972) |
| "Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment." | 7.65 | Use of diazoxide in hypertension with renal failure. ( Pohl, JE; Thurston, H, 1971) |
| "Diazoxide was originally approved as an anti-hypertensive medication, but also is known to bind ATP-sensitive K channels in the beta cells of the pancreas, ultimately leading to inhibition of insulin release." | 5.56 | The use of diazoxide in the management of spontaneous hypoglycemia in patients with ESRD. ( Kristan, M; Lamos, EM; Malek, R; Mesmar, B; Munir, KM; Satyarengga, M, 2020) |
| "Diazoxide was given orally to nine hypertensive patients with renal failure and its effect on blood pressure and on glucose metabolism was studied." | 5.25 | Oral diazoxide contraindicated in severe hypertension with renal failure. ( Belpaire, FM; De Broe, ME; Mussche, MM; Ringoir, SM; Vermeulen, A, 1975) |
| " The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia." | 3.81 | Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide. ( Aso, Y; Hiraishi, H; Kojima, M; Shimizu, M; Suzuki, K; Tsuchida, K, 2015) |
| "Treatment with oral diazoxide for periods of 4 to 10 weeks in hospital allowed adequate control of hypertension with continuation of fetal growth in four patients with severe toxaemia." | 3.65 | Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy. ( Davis, D; Morgan, MY; Pohl, JE; Thurston, H, 1972) |
| "Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment." | 3.65 | Use of diazoxide in hypertension with renal failure. ( Pohl, JE; Thurston, H, 1971) |
| "Diazoxide was originally approved as an anti-hypertensive medication, but also is known to bind ATP-sensitive K channels in the beta cells of the pancreas, ultimately leading to inhibition of insulin release." | 1.56 | The use of diazoxide in the management of spontaneous hypoglycemia in patients with ESRD. ( Kristan, M; Lamos, EM; Malek, R; Mesmar, B; Munir, KM; Satyarengga, M, 2020) |
| "Renal disease and hypertension is a continuing challenge to the nephrologist." | 1.26 | The kidney and antihypertensive therapy. ( Bailey, RR, 1976) |
| "Cause of renal disease are chronic renal failure in three, acute renal failure in three, hemolytic uremic syndrome in two, acute post streptococcal glomerulonephritis in one, and renal arterial stenosis in a further patient." | 1.26 | [Hypertensive emergencies in children with renal hypertension (author's transl)]. ( Bachmann, HJ; Olbing, H; Pistor, K, 1979) |
| "Diazoxide was also shown to be less highly protein bound in patients with renal failure." | 1.26 | Renal function, protein binding and pharmacological response to diazoxide. ( Breckenridge, AM; Pearson, RM, 1976) |
| "Diazoxide was given orally to nine hypertensive patients with renal failure and its effect on blood pressure and on glucose metabolism was studied." | 1.25 | Oral diazoxide contraindicated in severe hypertension with renal failure. ( Belpaire, FM; De Broe, ME; Mussche, MM; Ringoir, SM; Vermeulen, A, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (90.91) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Mesmar, B | 1 |
| Kristan, M | 1 |
| Satyarengga, M | 1 |
| Lamos, EM | 1 |
| Malek, R | 1 |
| Munir, KM | 1 |
| Shimizu, M | 1 |
| Suzuki, K | 1 |
| Tsuchida, K | 1 |
| Kojima, M | 1 |
| Hiraishi, H | 1 |
| Aso, Y | 1 |
| Pérez Mijares, R | 1 |
| Elosegui, A | 1 |
| Praga, M | 1 |
| Vidaur, F | 1 |
| Izaguirre, A | 1 |
| Argoitia, A | 1 |
| López de Novales, E | 1 |
| Bailey, RR | 1 |
| Weidmann, P | 2 |
| Keusch, G | 2 |
| Bachmann, HJ | 1 |
| Olbing, H | 1 |
| Pistor, K | 1 |
| Mussche, MM | 1 |
| De Broe, ME | 1 |
| Belpaire, FM | 1 |
| Vermeulen, A | 1 |
| Ringoir, SM | 1 |
| White, RP | 1 |
| Nolph, KD | 1 |
| Ghods, AJ | 1 |
| Van Stone, J | 1 |
| Brown, PA | 1 |
| Pearson, RM | 1 |
| Breckenridge, AM | 1 |
| Prejac, M | 1 |
| Jeren, B | 1 |
| Crnjaković, J | 1 |
| Diekmann, L | 1 |
| Thurston, H | 4 |
| Pohl, JE | 4 |
| Swales, JD | 2 |
| Mroczek, WJ | 1 |
| Fillastre, JP | 1 |
| Malandain, M | 1 |
| Gray, H | 1 |
| Dubois, D | 1 |
| Baer, L | 1 |
| Goodwin, FJ | 1 |
| Laragh, JH | 1 |
| Davis, D | 1 |
| Morgan, MY | 1 |
| Richet, G | 1 |
| Ducrot, H | 1 |
| Hamburger, J | 1 |
| Legrain, M | 1 |
| Maxwell, M | 1 |
| Péquignot, MH | 1 |
3 reviews available for diazoxide and Kidney Failure, Chronic
| Article | Year |
|---|---|
[Treatment of therapy-resistant hypertension].
Topics: Adrenergic beta-Antagonists; Diazoxide; Diuretics; Drug Resistance; Drug Therapy, Combination; Human | 1977 |
[Treatment of therapy-resistant hypertension].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Carotid S | 1977 |
Malignant hypertension: kidneys too good to be extirpated.
Topics: Animals; Blood Pressure; Diazoxide; Furosemide; Glomerulonephritis; Humans; Hypertension, Malignant; | 1974 |
1 trial available for diazoxide and Kidney Failure, Chronic
| Article | Year |
|---|---|
Diazoxide-induced renin release in man: dissociation from plasma and extracellular fluid volume changes.
Topics: Adult; Blood Pressure; Blood Volume; Clinical Trials as Topic; Diazoxide; Extracellular Space; Femal | 1969 |
18 other studies available for diazoxide and Kidney Failure, Chronic
| Article | Year |
|---|---|
The use of diazoxide in the management of spontaneous hypoglycemia in patients with ESRD.
Topics: Aged; Diazoxide; Female; Humans; Hypertension, Renal; Hypoglycemia; Kidney Failure, Chronic; Male; M | 2020 |
Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide.
Topics: Antihypertensive Agents; Biomarkers, Tumor; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Dia | 2015 |
[Hypertrichosis following prolonged use of i.v. diazoxide. Apropos of a case].
Topics: Adolescent; Diazoxide; Female; Humans; Hypertension, Renal; Hypertrichosis; Infusions, Parenteral; K | 1981 |
The kidney and antihypertensive therapy.
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Clonidine; Diazoxide; Female; Humans; Hy | 1976 |
[Hypertensive emergencies in children with renal hypertension (author's transl)].
Topics: Acute Disease; Acute Kidney Injury; Child; Child, Preschool; Diazoxide; Female; Glomerulonephritis; | 1979 |
Oral diazoxide contraindicated in severe hypertension with renal failure.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Blood Glucose; Diabetic Ketoacidosis; Diazoxide; F | 1975 |
Antihypertensive agents in renal disease.
Topics: Antihypertensive Agents; Body Water; Clonidine; Diazoxide; Ethacrynic Acid; Furosemide; Guanethidine | 1977 |
The effects of intraperitoneal vasodilators on peritoneal clearances.
Topics: Capillaries; Creatinine; Diazoxide; Humans; Hydralazine; Isoproterenol; Kidney Failure, Chronic; Met | 1976 |
Renal function, protein binding and pharmacological response to diazoxide.
Topics: Adult; Blood Pressure; Diazoxide; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middl | 1976 |
[Diazoxide administered to control hypertension in patients on extracorporeal hemodialysis (author's transl)].
Topics: Adolescent; Adult; Child; Diazoxide; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Mi | 1976 |
[The acute crisis of blood pressure and its treatment in childhood (authors transl)].
Topics: Acute Disease; Acute Kidney Injury; Administration, Oral; Adolescent; Age Factors; Child; Diazoxide; | 1975 |
Refractory hypertension.
Topics: Administration, Oral; Antihypertensive Agents; Chronic Disease; Diazoxide; Drug Combinations; Drug R | 1973 |
The effect of oral diazoxide on hypertension and sodium excretion in chronic renal failure.
Topics: Blood Glucose; Carbohydrates; Creatinine; Diazoxide; Edema; Glomerulonephritis; Humans; Hypertension | 1973 |
[Treatment of malignant nephroangiosclerosis with diazoxide].
Topics: Diazoxide; Glomerular Filtration Rate; Humans; Hydralazine; Hypertension, Malignant; Injections, Int | 1972 |
Sodium conservation in chronic renal failure: studies using oral diazoxide.
Topics: Administration, Oral; Creatinine; Diazoxide; Fludrocortisone; Furosemide; Humans; Hyponatremia; Kidn | 1972 |
Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy.
Topics: Acute Disease; Administration, Oral; Adult; Albuminuria; Blood Glucose; Diazoxide; Female; Furosemid | 1972 |
Use of diazoxide in hypertension with renal failure.
Topics: Adolescent; Adult; Blood Glucose; Creatine; Diazoxide; Dietary Proteins; Female; Humans; Hyperglycem | 1971 |
[May medical therapy of arterial hypertension by used in patients with renal failure?].
Topics: Antihypertensive Agents; Diazoxide; Drug Tolerance; Guanethidine; Humans; Hydralazine; Hypertension; | 1968 |