diazoxide has been researched along with Intraocular Pressure in 6 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the expression of ATP-sensitive potassium (K(ATP)) channel subunits and study the effect of K(ATP) channel openers diazoxide and nicorandil on intraocular pressure (IOP) in an in vivo mouse model." | 7.79 | ATP-sensitive potassium (K(ATP)) channel openers diazoxide and nicorandil lower intraocular pressure in vivo. ( Chowdhury, UR; Fautsch, MP; Holman, BH, 2013) |
| "Elevated intraocular pressure is the most prevalent and only treatable risk factor for glaucoma, a degenerative disease of the optic nerve." | 5.46 | ATP-sensitive potassium (KATP) channel openers diazoxide and nicorandil lower intraocular pressure by activating the Erk1/2 signaling pathway. ( Bahler, CK; Fautsch, MP; Holman, BH; Roy Chowdhury, U, 2017) |
| "To evaluate the effect of ATP-sensitive potassium channel openers cromakalim prodrug 1 (CKLP1) and diazoxide on IOP in three independent mouse models of ocular hypertension." | 4.12 | Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models. ( Anderson, KJ; Dosa, PI; Fautsch, MP; Holman, BH; Millar, JC; Roddy, GW; Roy Chowdhury, U, 2022) |
| "To evaluate the expression of ATP-sensitive potassium (K(ATP)) channel subunits and study the effect of K(ATP) channel openers diazoxide and nicorandil on intraocular pressure (IOP) in an in vivo mouse model." | 3.79 | ATP-sensitive potassium (K(ATP)) channel openers diazoxide and nicorandil lower intraocular pressure in vivo. ( Chowdhury, UR; Fautsch, MP; Holman, BH, 2013) |
| "Elevated intraocular pressure is the most prevalent and only treatable risk factor for glaucoma, a degenerative disease of the optic nerve." | 1.46 | ATP-sensitive potassium (KATP) channel openers diazoxide and nicorandil lower intraocular pressure by activating the Erk1/2 signaling pathway. ( Bahler, CK; Fautsch, MP; Holman, BH; Roy Chowdhury, U, 2017) |
| "IPC or ischemia was induced in rat retina in vivo." | 1.35 | Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning. ( Barone, FC; Dreixler, JC; Du, E; Roth, S; Shaikh, AR, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Roy Chowdhury, U | 3 |
| Millar, JC | 1 |
| Holman, BH | 3 |
| Anderson, KJ | 1 |
| Dosa, PI | 2 |
| Roddy, GW | 1 |
| Fautsch, MP | 5 |
| Bahler, CK | 2 |
| Chowdhury, UR | 2 |
| Dreixler, JC | 1 |
| Barone, FC | 1 |
| Shaikh, AR | 1 |
| Du, E | 1 |
| Roth, S | 1 |
| Hann, CR | 1 |
| Chang, M | 1 |
| Resch, ZT | 1 |
| Romero, MF | 1 |
1 review available for diazoxide and Intraocular Pressure
| Article | Year |
|---|---|
ATP sensitive potassium channel openers: A new class of ocular hypotensive agents.
Topics: Animals; Antihypertensive Agents; Cromakalim; Diazoxide; Glaucoma; Humans; Intraocular Pressure; KAT | 2017 |
5 other studies available for diazoxide and Intraocular Pressure
| Article | Year |
|---|---|
Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models.
Topics: Animals; Antihypertensive Agents; Cromakalim; Diazoxide; Disease Models, Animal; Eye; Intraocular Pr | 2022 |
ATP-sensitive potassium (KATP) channel openers diazoxide and nicorandil lower intraocular pressure by activating the Erk1/2 signaling pathway.
Topics: Adult; Aged; Aged, 80 and over; Animals; Butadienes; Cells, Cultured; Diazoxide; Enzyme Activation; | 2017 |
ATP-sensitive potassium (K(ATP)) channel openers diazoxide and nicorandil lower intraocular pressure in vivo.
Topics: Animals; Diazoxide; Eye; Immunohistochemistry; Intraocular Pressure; KATP Channels; Mice; Mice, Inbr | 2013 |
Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Anisomycin; Diazoxide | 2009 |
ATP-sensitive potassium (KATP) channel activation decreases intraocular pressure in the anterior chamber of the eye.
Topics: Aged; Aged, 80 and over; Animals; Cells, Cultured; Diazoxide; Female; Glyburide; Guanidines; Humans; | 2011 |