diazoxide has been researched along with Intellectual Disability in 15 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since 1969 leucine sensitive hypoglycemia has been diagnosed in 4 infants." | 7.65 | [Leucine sensitive hypoglycemia. Follow-up studies under treatment with diazoxide (author's transl)]. ( Lücking, T, 1976) |
| "Since 1969 leucine sensitive hypoglycemia has been diagnosed in 4 infants." | 3.65 | [Leucine sensitive hypoglycemia. Follow-up studies under treatment with diazoxide (author's transl)]. ( Lücking, T, 1976) |
| "This syndrome is characterised by recurrent episodes of hypoglycaemia and elevated ammonia levels, which are potentially harmful to both the patient and a developing fetus." | 1.56 | Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome. ( Bazelmans, M; Benner, BJM; Huidekoper, H; Langendonk, J; Langeveld, M; Schoenmakers, S, 2020) |
| "All four patients with mental retardation had a delay in the maintenance of euglycemia, and three of them also had seizure disorder." | 1.43 | Clinical characteristics and long-term outcome of Taiwanese children with congenital hyperinsulinism. ( Chiu, PC; Lee, CT; Liu, SY; Tsai, WY; Tung, YC; Wu, MZ, 2016) |
| "Hypoglycemia has been documented due to growth hormone and cortisol deficiency." | 1.33 | Costello syndrome and hyperinsulinemic hypoglycemia. ( Al-Sharkawi, I; Alexander, S; Alkhayyat, H; Backer, KC; El-Sabban, F; Hussain, K; Ramadan, D, 2005) |
| "The third has occasional fasting hypoglycemia that is treated with diazoxide; he continues to have a seizure disorder and is mentally retarded." | 1.26 | Nesidioblastosis in children. ( Danis, RK; Garvin, PJ; Knight, J; Lewis, JE; Willman, VL, 1980) |
| "To avoid mental retardation, surgical intervention should not be considered as a last resort." | 1.26 | Near-total pancreatectomy in persistent infantile hypoglycemia. ( Moazam, F; Rodgers, BM; Rosenbloom, AL; Talbert, JL, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Benner, BJM | 1 |
| Bazelmans, M | 1 |
| Huidekoper, H | 1 |
| Langeveld, M | 1 |
| Langendonk, J | 1 |
| Schoenmakers, S | 1 |
| Kostopoulou, E | 1 |
| Dastamani, A | 1 |
| Caiulo, S | 1 |
| Antell, H | 1 |
| Flanagan, SE | 1 |
| Shah, P | 1 |
| Ağladıoğlu, SY | 1 |
| Savaş Erdeve, S | 1 |
| Cetinkaya, S | 1 |
| Baş, VN | 1 |
| Peltek Kendirci, HN | 1 |
| Onder, A | 1 |
| Aycan, Z | 1 |
| Lee, CT | 1 |
| Liu, SY | 1 |
| Tung, YC | 1 |
| Chiu, PC | 1 |
| Wu, MZ | 1 |
| Tsai, WY | 1 |
| Alexander, S | 1 |
| Ramadan, D | 1 |
| Alkhayyat, H | 1 |
| Al-Sharkawi, I | 1 |
| Backer, KC | 1 |
| El-Sabban, F | 1 |
| Hussain, K | 1 |
| Ismail, D | 1 |
| Werther, G | 1 |
| Knight, J | 1 |
| Garvin, PJ | 1 |
| Danis, RK | 1 |
| Lewis, JE | 1 |
| Willman, VL | 1 |
| Moazam, F | 1 |
| Rodgers, BM | 1 |
| Talbert, JL | 1 |
| Rosenbloom, AL | 1 |
| Lücking, T | 1 |
| Grant, DB | 1 |
| Dunger, DB | 1 |
| Burns, EC | 1 |
| Schwartz, JF | 1 |
| Zwiren, GT | 1 |
| Carney, MW | 1 |
| Weinbren, I | 1 |
| Purnell, GV | 1 |
| Sheffield, BF | 1 |
| Hansson, O | 1 |
| Tuvemo, T | 1 |
| Westphal, O | 1 |
| Victorin, LH | 1 |
| Thorell, JI | 1 |
| Mereu, TR | 1 |
| Kassoff, A | 1 |
| Goodman, AD | 1 |
15 other studies available for diazoxide and Intellectual Disability
| Article | Year |
|---|---|
Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome.
Topics: Adult; Diazoxide; Diet, Carbohydrate Loading; Directive Counseling; Female; Humans; Hyperammonemia; | 2020 |
Hyperinsulinaemic hypoglycaemia: A new presentation of 16p11.2 deletion syndrome.
Topics: Autistic Disorder; Chromosome Deletion; Chromosome Disorders; Chromosomes, Human, Pair 16; Congenita | 2019 |
Hyperinsulinemic hypoglycemia: experience in a series of 17 cases.
Topics: Child; Child, Preschool; Developmental Disabilities; Diazoxide; Epilepsy; Female; Humans; Hyperinsul | 2013 |
Clinical characteristics and long-term outcome of Taiwanese children with congenital hyperinsulinism.
Topics: Age of Onset; Congenital Hyperinsulinism; Diabetes Mellitus; Diazoxide; Female; Follow-Up Studies; G | 2016 |
Costello syndrome and hyperinsulinemic hypoglycemia.
Topics: Abnormalities, Multiple; Diazoxide; Fatal Outcome; Female; Humans; Hyperinsulinism; Hypoglycemia; In | 2005 |
Persistent hyperinsulinaemic hypoglycaemia of infancy: 15 years' experience at the Royal Children's Hospital (RCH), Melbourne.
Topics: Adolescent; Child; Child, Preschool; Congenital Hyperinsulinism; Diazoxide; Female; Hospitals, Pedia | 2005 |
Nesidioblastosis in children.
Topics: Adenoma, Islet Cell; Child, Preschool; Diazoxide; Female; Glucagon; Glucose; Humans; Hyperinsulinism | 1980 |
Near-total pancreatectomy in persistent infantile hypoglycemia.
Topics: Adenoma; Adenoma, Islet Cell; Diazoxide; Female; Humans; Hyperplasia; Hypoglycemia; Infant; Infant, | 1982 |
[Leucine sensitive hypoglycemia. Follow-up studies under treatment with diazoxide (author's transl)].
Topics: Blood Glucose; Diazoxide; Dietary Proteins; Drug Hypersensitivity; Epilepsy; Female; Humans; Hypertr | 1976 |
Long-term treatment with diazoxide in childhood hyperinsulinism.
Topics: Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, Newborn; Intellectual Disability; | 1986 |
Islet cell adenomatosis and adenoma in an infant.
Topics: Adenoma, Islet Cell; Adrenocorticotropic Hormone; Diazoxide; Glucose; Humans; Hypoglycemia; Infant, | 1971 |
Reversal of adult mental subnormality.
Topics: Adenoma, Islet Cell; Adult; Diazoxide; Humans; Intellectual Disability; Intelligence Tests; Male | 1972 |
[Diazoxide as therapy for idiopathic hypoglycemia in children (author's transl)].
Topics: Catecholamines; Child; Child, Preschool; Cyanosis; Diazoxide; Diet Therapy; Fasting; Female; Fever; | 1974 |
Plasma insulin and blood glucose during long-term treatment with diazoxide for infant hypoglycemia.
Topics: Acidosis; Blood Glucose; Child, Preschool; Diazoxide; Follow-Up Studies; Glucose; Glucose Tolerance | 1974 |
Diazoxide in the treatment of infantile hypoglycemia.
Topics: Autoanalysis; Diazoxide; Drug Hypersensitivity; Female; Glucose Tolerance Test; Hirsutism; Humans; H | 1966 |