Page last updated: 2024-10-25

diazoxide and Insulinoma

diazoxide has been researched along with Insulinoma in 74 studies

Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.

Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.

Research Excerpts

ExcerptRelevanceReference
"Diazoxide is recognized as an effective medical treatment for insulinoma."7.91Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide. ( Hashimoto, K; Izumiyama, H; Kudo, A; Minami, I; Niitsu, Y; Ogawa, Y; Ota, K; Satou, F; Tanabe, M; Tsujino, M; Yamada, T; Yoshimoto, T, 2019)
" The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia."7.81Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide. ( Aso, Y; Hiraishi, H; Kojima, M; Shimizu, M; Suzuki, K; Tsuchida, K, 2015)
" We diagnosed her with insulinoma and initiated diazoxide treatment to prevent hypoglycemia."7.80Thrombocytopenia induced by diazoxide in a patient with an insulinoma. ( Adachi, J; Kakihana, K; Mimura, M; Minami, I; Watanabe, T, 2014)
"A survey of UK patients receiving the drug diazoxide, revealed 40 patients with insulinoma on this treatment."7.69Diazoxide treatment for insulinoma: a national UK survey. ( Gill, GV; MacFarlane, IA; Rauf, O, 1997)
"The use of diazoxide in patients with insulinoma has been evaluated using the euglycaemic clamp technique."7.67Use of euglycaemic clamping in evaluation of diazoxide treatment of insulinoma. ( Páv, J; Skrha, J; Srámková, J; Svacina, S, 1989)
"Surgery is the ideal treatment of insulinoma."5.72Preoperative treatment of benign insulinoma: diazoxide or somatostatin analogues? ( Bertrand, C; Donckier, JE; Gilliaux, Q; Hanon, F, 2022)
" Although patients with hyperinsulinemic hypoglycemia worldwide have been treated with diazoxide for more than 30 years, there are no recent reports about the adverse effects of this drug in Asian patients, including Japanese patients."5.43Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( Inoue, Y; Komatsu, Y; Miyoshi, H; Nakamura, A; Tajima, K; Takano, T; Takihata, M; Terauchi, Y; Tsuchiya, H; Yahagi, S; Yamakawa, T; Yoshida, M, 2016)
"Insulinomas are islet cell tumors of the pancreas that produce hypoglycemia due to inappropriate insulin secretion."5.32[Treatment of insulinoma with diazoxide]. ( Cristino, A; Fainstein, D; González Pardo, FO; Lasdica, S; Mateu, MV, 2003)
"Thus, alpha-TC glucagonoma cells contain ATP-sensitive K+ channels that regulate glucagon release, yet allow inhibition of hormone release by glucose."5.29Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells. ( Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P, 1993)
" Medical control of the hormonal syndrome with agents such as diazoxide for insulinoma, omeprazole for gastrinoma, and octreotide for vipoma and glucagonoma allows an orderly and thorough investigation for associated endocrinopathies and comorbid medical conditions."4.79Islet cell tumors. ( Stabile, BE, 1997)
"Diazoxide is recognized as an effective medical treatment for insulinoma."3.91Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide. ( Hashimoto, K; Izumiyama, H; Kudo, A; Minami, I; Niitsu, Y; Ogawa, Y; Ota, K; Satou, F; Tanabe, M; Tsujino, M; Yamada, T; Yoshimoto, T, 2019)
" The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia."3.81Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide. ( Aso, Y; Hiraishi, H; Kojima, M; Shimizu, M; Suzuki, K; Tsuchida, K, 2015)
" We diagnosed her with insulinoma and initiated diazoxide treatment to prevent hypoglycemia."3.80Thrombocytopenia induced by diazoxide in a patient with an insulinoma. ( Adachi, J; Kakihana, K; Mimura, M; Minami, I; Watanabe, T, 2014)
"Diazoxide treatment for presumptive insulinoma was started at a dosage of 5 mg/kg (2."3.79Diagnosis and treatment of an insulinoma in a guinea pig (Cavia porcellus). ( Hess, LR; Ravich, ML; Reavill, DR, 2013)
"In conclusion, this case may suggest that biologic behavior may differ from histological behavior in insulinoma and platin-based systemic chemotherapy may provide some benefit in patients those who had diazoxide- and octreotide-resistant tumors."3.76Rapidly progressing malignant insulinoma presented with multiple liver metastases: a case report. ( Akkaya, H; Askin, E; Bascil Tutuncu, N; Erdogan, A; Fatih, K; Hampar, A; Kose, F; Ozgur, O; Ozyilkan, O; Tutuncu, NB, 2010)
"Organic hyperinsulinism is treated as a rule conservatively with diazoxide (Proglicem) which has a hyperglycaemic effect."3.69[The effect of Proglicem in patients with an organic hyperinsulinism syndrome]. ( Justová, V; Sindelka, G; Skrha, J; Svacina, S; Wichterle, D, 1994)
" We describe a 72-year-old lady who initially presented with episodic hypoglycemia secondary to an insulinoma that was controlled by diazoxide."3.69Relapse of medically treated insulinoma following the development of thyrotoxicosis: an assessment of potential mechanisms. ( Alberti, KG; Kendall-Taylor, P; Trajano, LR; Walker, M, 1994)
"The effect on insulin release of efaroxan, an alpha 2-adrenoceptor antagonist and a highly potent drug at imidazoline I1 receptors, and the effects of seven other imidazoline compounds selective for the imidazoline I1 or I2 receptors, were studied in the rat insulinoma cell line RIN-5AH."3.69Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors. ( Haque, M; Kulkarni, RN; MacDermot, J; Olmos, G, 1994)
"A survey of UK patients receiving the drug diazoxide, revealed 40 patients with insulinoma on this treatment."3.69Diazoxide treatment for insulinoma: a national UK survey. ( Gill, GV; MacFarlane, IA; Rauf, O, 1997)
"We studied the release of insulin, glucagon, and somatostatin in response to glucose, glyceraldehyde (GA), and alpha-ketoisocaproate (KIC) from rat kidneys containing transplanted insulinomas."3.67Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney. ( Ferguson, DC; Hoenig, M; Matschinsky, FM, 1984)
"The use of diazoxide in patients with insulinoma has been evaluated using the euglycaemic clamp technique."3.67Use of euglycaemic clamping in evaluation of diazoxide treatment of insulinoma. ( Páv, J; Skrha, J; Srámková, J; Svacina, S, 1989)
" The enzyme in the insulinomas, but not that in the nearby pancreases, was inhibited by diazoxide, which is a known inhibitor of insulin secretion in vitro and in vivo."3.66Increased mitochondrial glycerol phosphate dehydrogenase activity in insulinomas of two hypoglycemic infants. ( MacDonald, MJ; Pellett, JR; Warner, TF, 1983)
"Hypoglycemia was not repeated on endocrinological examination, even while fasting."1.72Diagnosis and Treatment Course of Insulinoma Presenting as Hypoglycemia Unawareness Using a Factory-Calibrated Continuous Glucose Monitoring System. ( Aida, A; Noto, H, 2022)
"Surgery is the ideal treatment of insulinoma."1.72Preoperative treatment of benign insulinoma: diazoxide or somatostatin analogues? ( Bertrand, C; Donckier, JE; Gilliaux, Q; Hanon, F, 2022)
"Insulinomas are the most common cause of EHH."1.56Changing Insulinoma Management Due to Incidentally Discovered Metastasis: A Case Report. ( Chow, LS; Froelich, J; Madan, R; Mettler, T, 2020)
"Nesidioblastosis is a rare cause of adult hypoglycemia."1.51A Case Report of Insulinoma Relapse on Background Nesidioblastosis: A Rare Cause of Adult Hypoglycemia. ( Bonora, E; Castelli, C; Dauriz, M; Ferdeghini, M; Fuini, A; Landoni, L; Malleo, G; Maneschi, C; Moghetti, P; Tomezzoli, A, 2019)
"Most cases of insulinomas are benign."1.43A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma. ( Berberabe, A; Pagsisihan, D; Palugod-Lopez, EG; Sandoval, MA, 2016)
" Although patients with hyperinsulinemic hypoglycemia worldwide have been treated with diazoxide for more than 30 years, there are no recent reports about the adverse effects of this drug in Asian patients, including Japanese patients."1.43Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( Inoue, Y; Komatsu, Y; Miyoshi, H; Nakamura, A; Tajima, K; Takano, T; Takihata, M; Terauchi, Y; Tsuchiya, H; Yahagi, S; Yamakawa, T; Yoshida, M, 2016)
"Insulinomas are β-cell tumors that cause hypoglycemia through inappropriate secretion of insulin."1.42Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro. ( Guiot, Y; Henquin, JC; Nenquin, M; Rahier, J; Sempoux, C, 2015)
"Malignant insulinoma is an infrequent functional endocrine tumor of the pancreas."1.39Management of malignant insulinoma. ( Caballero-Díaz, C; Camps Herrero, C; Civera-Andrés, M; Ferrer-García, JC; Iranzo González-Cruz, V; Merchante-Alfaro, A; Morillas-Ariño, C; Navas-DeSolís, S; Sánchez-Juan, C, 2013)
"CGM in insulinoma is useful in detecting hypoglycaemia, and hypoglycaemia unawareness, monitoring response to medical therapy and for confirming cure postoperatively, and is useful in the management of this uncommon but dangerous condition."1.35Continuous glucose monitoring in patients with insulinoma. ( Choudhary, P; Harrison, B; Heller, S; Munir, A; Newell-Price, J, 2008)
"The treatment with diazoxide or infection of ORP150 antisense adenovirus suppressed ORP150 expression, and glucose-stimulated insulin secretion was effectively prevented."1.33150-kD oxygen-regulated protein is an essential factor for insulin release. ( Kobayashi, T; Ohta, Y, 2005)
"Although insulinoma is rare in the elderly and exceedingly rare in the context of type 2 diabetes, it should be given due consideration when no other exacerbating factor is found."1.33A mysterious case of normalising blood sugar: insulinoma in a long-standing diabetic patient. ( Hameed, MF; Hoyle, GE; Muir, Z, 2006)
"Insulinomas are islet cell tumors of the pancreas that produce hypoglycemia due to inappropriate insulin secretion."1.32[Treatment of insulinoma with diazoxide]. ( Cristino, A; Fainstein, D; González Pardo, FO; Lasdica, S; Mateu, MV, 2003)
" By applying the patch-clamp technique, dose-response curves for ATP and the sulfonylurea tolbutamide were obtained in inside-out patches."1.30RIN14B: a pancreatic delta-cell line that maintains functional ATP-dependent K+ channels and capability to secrete insulin under conditions where it no longer secretes somatostatin. ( Berggren, PO; Bränström, R; Höög, A; Larsson, O; Wahl, MA, 1997)
"Thus, alpha-TC glucagonoma cells contain ATP-sensitive K+ channels that regulate glucagon release, yet allow inhibition of hormone release by glucose."1.29Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells. ( Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P, 1993)
"Chlorpromazine inhibition was observed when KATP channels were activated by ATP depletion or by direct treatment with a classical KATP channel opener, diazoxide."1.28Chlorpromazine and related phenothiazines inhibit the ATP-sensitive K+ channel. ( De Weille, JR; Lazdunski, M; Müller, M, 1991)

Research

Studies (74)

TimeframeStudies, this research(%)All Research%
pre-199017 (22.97)18.7374
1990's20 (27.03)18.2507
2000's14 (18.92)29.6817
2010's19 (25.68)24.3611
2020's4 (5.41)2.80

Authors

AuthorsStudies
Aida, A1
Noto, H1
Gilliaux, Q1
Bertrand, C1
Hanon, F1
Donckier, JE1
Madan, R1
Mettler, T1
Froelich, J1
Chow, LS1
Sileo, F1
Cangiano, B1
Cacciatore, C1
Amarù, J1
Gatto, F1
Albertelli, M1
Falconi, M1
Vitale, G1
Persani, L1
Niitsu, Y1
Minami, I2
Izumiyama, H1
Hashimoto, K1
Yoshimoto, T1
Satou, F1
Tsujino, M1
Ota, K1
Kudo, A1
Tanabe, M1
Yamada, T1
Ogawa, Y1
Dauriz, M1
Maneschi, C1
Castelli, C1
Tomezzoli, A1
Fuini, A1
Landoni, L1
Malleo, G1
Ferdeghini, M1
Bonora, E1
Moghetti, P1
Ferrer-García, JC1
Iranzo González-Cruz, V1
Navas-DeSolís, S1
Civera-Andrés, M1
Morillas-Ariño, C1
Merchante-Alfaro, A1
Caballero-Díaz, C1
Sánchez-Juan, C1
Camps Herrero, C1
Dall, M1
Calloe, K1
Haupt-Jorgensen, M1
Larsen, J1
Schmitt, N1
Josefsen, K1
Buschard, K1
Tabarin, A1
Goichot, B1
Luppi, P1
Drain, P1
Adachi, J1
Mimura, M1
Kakihana, K1
Watanabe, T1
Shimizu, M1
Suzuki, K1
Tsuchida, K1
Kojima, M1
Hiraishi, H1
Aso, Y1
Henquin, JC1
Nenquin, M1
Guiot, Y1
Rahier, J1
Sempoux, C1
Komatsu, Y1
Nakamura, A1
Takihata, M1
Inoue, Y1
Yahagi, S1
Tajima, K1
Tsuchiya, H1
Takano, T1
Yamakawa, T1
Yoshida, M1
Miyoshi, H1
Terauchi, Y1
Sandoval, MA1
Pagsisihan, D1
Berberabe, A1
Palugod-Lopez, EG1
Tomohiro, S1
Yonemura, K1
Okuya, T1
Ominato, T1
Takano, R1
Suzuki, T1
Kato, M1
Shao, Y1
Qu, YQ1
Wang, XL1
Song, ZG1
Guo, QH1
Dou, JT1
Ba, JM1
Lü, ZH1
Mu, YM1
Erdogan, A1
Askin, E1
Kose, F1
Fatih, K1
Akkaya, H1
Hampar, A1
Bascil Tutuncu, N1
Tutuncu, NB1
Ozyilkan, O1
Ozgur, O1
Heimann, E1
Jones, HA1
Resjö, S1
Manganiello, VC1
Stenson, L1
Degerman, E1
Ross, JJ1
Vaidya, A1
Kaiser, UB1
Swaminathan, K1
Young, R1
Reid, W1
Levy, MJ1
Thompson, GB1
Topazian, MD1
Callstrom, MR1
Grant, CS1
Vella, A1
Hess, LR1
Ravich, ML1
Reavill, DR1
MacDonald, PE1
Sewing, S1
Wang, J2
Joseph, JW1
Smukler, SR1
Sakellaropoulos, G1
Saleh, MC1
Chan, CB1
Tsushima, RG1
Salapatek, AM1
Wheeler, MB1
Mateu, MV1
González Pardo, FO1
Cristino, A1
Lasdica, S1
Fainstein, D1
LUNDVALL, O1
JOHNSSON, S1
MARKS, V1
ROSE, FC1
SAMOLS, E1
Merglen, A1
Theander, S1
Rubi, B1
Chaffard, G1
Wollheim, CB1
Maechler, P1
Park, KH3
Akaike, T2
Arita, Y1
Ito, T1
Kobayashi, T1
Ohta, Y1
Yang, W1
Yang, G1
Jia, X1
Wu, L1
Wang, R1
Arao, T1
Okada, Y1
Hirose, A1
Tanaka, Y1
Hameed, MF1
Hoyle, GE1
Muir, Z1
Munir, A1
Choudhary, P1
Harrison, B1
Heller, S1
Newell-Price, J1
Turner, RC1
Dick, R1
Lee, EC1
Hoenig, M1
Ferguson, DC1
Matschinsky, FM2
Burch, PG1
McLeskey, CH1
Haemers, S1
Rottiers, R1
Parker, AJ1
Musselman, EM1
O'Brien, D1
Calzoni, D1
Guarneri, A1
Santamaria, A1
Tamburrano, G1
Lala, A1
Mauceri, M1
Leonetti, F1
Libianchi, S1
Andreani, D1
Berger, M1
Tsotsalas, M1
MacDonald, MJ1
Warner, TF1
Pellett, JR1
Paletto, AE1
Morino, F1
Boltri, F1
Camandona, M1
Robecchi, A1
Olmos, G1
Kulkarni, RN1
Haque, M1
MacDermot, J1
Walker, M1
Trajano, LR1
Alberti, KG1
Kendall-Taylor, P1
Sindelka, G1
Skrha, J3
Svacina, S2
Justová, V2
Wichterle, D1
Jaggar, JH1
Harding, EA1
Ayton, BA1
Dunne, MJ3
Hilgertová, J1
Ronner, P1
Hang, TL1
Epstein, AJ1
Buettger, C1
Sjöholm, A1
Arkhammar, P1
Welsh, N1
Bokvist, K1
Rorsman, P1
Hallberg, A1
Nilsson, T1
Welsh, M1
Berggren, PO2
Gromada, J1
Frøkjaer-Jensen, J1
Dissing, S1
Weinhaus, AJ1
Poronnik, P1
Tuch, BE1
Cook, DI1
Bränström, R1
Höög, A1
Wahl, MA1
Larsson, O1
Stabile, BE1
Gill, GV1
Rauf, O1
MacFarlane, IA1
Chapman, JC1
McClenaghan, NH2
Cosgrove, KE1
Hashmi, MN1
Shepherd, RM1
Giesberts, AN1
White, SJ1
Ammälä, C1
Flatt, PR2
Kim, SW1
Bae, YH1
Shaer, AJ1
Szewczyk, A1
De Weille, JR2
Lazdunski, M2
Müller, M1
Ulrich, FE1
Schneyer, U1
Hädecke, J1
Takeda, H1
Watanabe, K1
Suzuki, D1
Miyano, R1
Tanaka, K1
Machimura, H1
Yagame, M1
Inoue, W1
Kaneshige, H1
Sakai, H1
Nauck, M1
Stöckmann, F1
Creutzfeldt, W1
Meleo, K1
Srámková, J1
Páv, J1
Bahloul, F1
Goode, PN1
Farndon, JR1
Anderson, J1
Johnston, ID1
Morte, JA1
Boden, G1
Ryan, IG1
Shuman, CR1
Nelson, RW1
Foodman, MS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563]Phase 270 participants (Anticipated)Interventional2023-03-14Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for diazoxide and Insulinoma

ArticleYear
[Diagnosis and treatment of insulinoma].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2004, Volume: 101, Issue:4

    Topics: Antineoplastic Agents; Blood Glucose; Chemoembolization, Therapeutic; Diazoxide; Fasting; Glucagon;

2004
[Localization of beta-Langerhans tumors secreting hypoglycemics].
    Journees annuelles de diabetologie de l'Hotel-Dieu, 1983

    Topics: Adenoma, Islet Cell; Angiography; Diazoxide; Humans; Insulin; Insulinoma; Intraoperative Period; Lap

1983
Islet cell tumors.
    The Gastroenterologist, 1997, Volume: 5, Issue:3

    Topics: Adenoma, Islet Cell; Diazoxide; Gastrinoma; Humans; Hypoglycemia; Insulinoma; Octreotide; Pancreatic

1997
Management of insuloma patients with refractory hypoglycemia.
    Problems in veterinary medicine, 1990, Volume: 2, Issue:4

    Topics: Animals; Diazoxide; Dog Diseases; Dogs; Glucocorticoids; Hypoglycemia; Insulinoma; Prognosis; Somato

1990
Medical management of canine hyperinsulinism.
    Journal of the American Veterinary Medical Association, 1985, Jul-01, Volume: 187, Issue:1

    Topics: Adrenal Cortex Hormones; Animals; Blood Glucose; Combined Modality Therapy; Diazoxide; Diet Therapy;

1985

Other Studies

69 other studies available for diazoxide and Insulinoma

ArticleYear
Diagnosis and Treatment Course of Insulinoma Presenting as Hypoglycemia Unawareness Using a Factory-Calibrated Continuous Glucose Monitoring System.
    The American journal of case reports, 2022, Jul-31, Volume: 23

    Topics: Adult; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Complications; Diazoxide; Humans; Hype

2022
Preoperative treatment of benign insulinoma: diazoxide or somatostatin analogues?
    Acta chirurgica Belgica, 2022, Volume: 122, Issue:2

    Topics: Adult; Diazoxide; Humans; Insulinoma; Octreotide; Pancreatic Neoplasms; Somatostatin

2022
Changing Insulinoma Management Due to Incidentally Discovered Metastasis: A Case Report.
    The American journal of case reports, 2020, Jun-14, Volume: 21

    Topics: Ablation Techniques; Bone Neoplasms; Diagnosis, Differential; Diazoxide; Endosonography; Female; Hum

2020
Off-label pasireotide treatment in one insulinoma patient with an atypical presentation and intolerant to diazoxide.
    Endocrine, 2020, Volume: 70, Issue:2

    Topics: Diazoxide; Humans; Insulinoma; Off-Label Use; Pancreatic Neoplasms; Somatostatin

2020
Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide.
    Endocrine journal, 2019, Feb-28, Volume: 66, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Diazoxide; Female; Humans; Insuli

2019
A Case Report of Insulinoma Relapse on Background Nesidioblastosis: A Rare Cause of Adult Hypoglycemia.
    The Journal of clinical endocrinology and metabolism, 2019, 03-01, Volume: 104, Issue:3

    Topics: Diazoxide; Female; Humans; Hypoglycemia; Insulinoma; Middle Aged; Neoplasm Recurrence, Local; Nesidi

2019
Management of malignant insulinoma.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2013, Volume: 15, Issue:9

    Topics: Adult; Aged; Chemoembolization, Therapeutic; Diazoxide; Everolimus; Female; Glucocorticoids; Humans;

2013
Gliadin fragments and a specific gliadin 33-mer peptide close KATP channels and induce insulin secretion in INS-1E cells and rat islets of langerhans.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Action Potentials; Amino Acid Sequence; Animals; Blood Glucose; Body Weight; Cell Line; Cell Line, T

2013
Treatment: symptomatic treatment of hypoglycaemia.
    Annales d'endocrinologie, 2013, Volume: 74, Issue:3

    Topics: Antineoplastic Agents; Blood Glucose; Diazoxide; Everolimus; Humans; Hypoglycemia; Insulinoma; Octre

2013
Autocrine C-peptide mechanism underlying INS1 beta cell adaptation to oxidative stress.
    Diabetes/metabolism research and reviews, 2014, Volume: 30, Issue:7

    Topics: Adaptation, Physiological; Animals; Apoptosis; Autocrine Communication; C-Peptide; Cell Line, Tumor;

2014
Thrombocytopenia induced by diazoxide in a patient with an insulinoma.
    Internal medicine (Tokyo, Japan), 2014, Volume: 53, Issue:7

    Topics: Biopsy; Diagnosis, Differential; Diazoxide; Female; Humans; Insulinoma; Pancreatic Neoplasms; Thromb

2014
Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide.
    Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:6

    Topics: Antihypertensive Agents; Biomarkers, Tumor; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Dia

2015
Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro.
    Diabetes, 2015, Volume: 64, Issue:10

    Topics: Adult; Aged, 80 and over; Calcium Chloride; Diazoxide; Female; Gene Expression Regulation; Glucose;

2015
Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia.
    Endocrine journal, 2016, Volume: 63, Issue:3

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Diazoxide; Drug Monitoring; Drug Resistance; Edema

2016
A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma.
    BMJ case reports, 2016, Mar-18, Volume: 2016

    Topics: Biopsy; Blood Glucose; C-Peptide; Carcinoma, Neuroendocrine; Diazoxide; Humans; Hyperinsulinism; Hyp

2016
[Case Report; A case of geriatric insulinoma successfully treated by diazoxide].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2014, Nov-10, Volume: 103, Issue:11

    Topics: Aged, 80 and over; Diazoxide; Humans; Insulinoma; Male; Treatment Outcome

2014
Malignant insulinoma: Report of 6 patients and literature review.
    Neuro endocrinology letters, 2016, Volume: 37, Issue:3

    Topics: Adult; Diazoxide; Diuretics; Female; Humans; Hypoglycemia; Insulinoma; Liver Neoplasms; Male; Middle

2016
Rapidly progressing malignant insulinoma presented with multiple liver metastases: a case report.
    Journal of gastrointestinal cancer, 2010, Volume: 41, Issue:4

    Topics: Antineoplastic Agents; Diazoxide; Fatal Outcome; Female; Humans; Insulinoma; Liver Neoplasms; Middle

2010
Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets.
    PloS one, 2010, Dec-01, Volume: 5, Issue:12

    Topics: Animals; Cell Line, Tumor; Cyclic Nucleotide Phosphodiesterases, Type 3; Diazoxide; Gene Expression

2010
Interactive medical case. Lying low.
    The New England journal of medicine, 2011, Feb-10, Volume: 364, Issue:6

    Topics: Aged, 80 and over; Confusion; Diazoxide; Dizziness; Female; Humans; Hypoglycemia; Insulinoma; Magnet

2011
The diagnosis was in her birthday party!
    QJM : monthly journal of the Association of Physicians, 2012, Volume: 105, Issue:5

    Topics: Aged, 80 and over; Blood Glucose; C-Peptide; Confusion; Diazoxide; Epilepsy, Tonic-Clonic; Female; H

2012
US-guided ethanol ablation of insulinomas: a new treatment option.
    Gastrointestinal endoscopy, 2012, Volume: 75, Issue:1

    Topics: Ablation Techniques; Adult; Aged; Aged, 80 and over; Blood Glucose; Diazoxide; Endosonography; Ethan

2012
Diagnosis and treatment of an insulinoma in a guinea pig (Cavia porcellus).
    Journal of the American Veterinary Medical Association, 2013, Feb-15, Volume: 242, Issue:4

    Topics: Animals; Antihypertensive Agents; Blood Glucose; Diazoxide; Guinea Pigs; Insulinoma; Male; Pancreati

2013
Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.
    The Journal of biological chemistry, 2002, Nov-22, Volume: 277, Issue:47

    Topics: Animals; Calcium; Calcium Channel Blockers; Delayed Rectifier Potassium Channels; Diazoxide; Female;

2002
[Treatment of insulinoma with diazoxide].
    Medicina, 2003, Volume: 63, Issue:1

    Topics: Aged; Diazoxide; Humans; Insulinoma; Male; Pancreatic Neoplasms; Vasodilator Agents

2003
[INSULOMA TREATED WITH DIAZOXIDE].
    Nordisk medicin, 1965, Jan-21, Volume: 73

    Topics: Adenoma, Islet Cell; Antihypertensive Agents; Chlorthalidone; Diabetes Mellitus; Diazoxide; Geriatri

1965
HYPERINSULINISM DUE TO METASTASIZING INSULINOMA: TREATMENT WITH DIAZOXIDE.
    Proceedings of the Royal Society of Medicine, 1965, Volume: 58

    Topics: Adenoma, Islet Cell; Diazoxide; Drug Therapy; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulino

1965
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.
    Endocrinology, 2004, Volume: 145, Issue:2

    Topics: Adenosine Triphosphate; Animals; Calcium; Cell Differentiation; Cell Division; Cytosol; Diazoxide; E

2004
Visualization of the specific interaction of sulfonylurea-incorporated polymer with insulinoma cell line MIN6.
    Journal of biochemistry, 2004, Volume: 135, Issue:2

    Topics: Adenosine Triphosphate; Animals; Cell Line; Culture Media, Conditioned; Diazoxide; Dose-Response Rel

2004
150-kD oxygen-regulated protein is an essential factor for insulin release.
    Pancreas, 2005, Volume: 30, Issue:4

    Topics: Adenoviridae; Animals; Antisense Elements (Genetics); Cell Line, Tumor; Cromakalim; Diazoxide; Genes

2005
Probing of specific binding of synthetic sulfonylurea with the insulinoma cell line MIN6.
    Journal of biochemistry, 2005, Volume: 138, Issue:1

    Topics: Calcium; Diazoxide; Glyburide; Hypoglycemic Agents; Insulinoma; Microscopy, Confocal; Pancreatic Neo

2005
Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms.
    The Journal of physiology, 2005, Dec-01, Volume: 569, Issue:Pt 2

    Topics: Adenosine Triphosphate; Animals; Blotting, Western; Cell Line, Tumor; Cystathionine gamma-Lyase; Dia

2005
A rare case of adult-onset nesidioblastosis treated successfully with diazoxide.
    Endocrine journal, 2006, Volume: 53, Issue:1

    Topics: Angiography; Blood Glucose; Diagnosis, Differential; Diazoxide; Humans; Hyperinsulinism; Hypoglycemi

2006
A mysterious case of normalising blood sugar: insulinoma in a long-standing diabetic patient.
    Age and ageing, 2006, Volume: 35, Issue:3

    Topics: Aged; Diabetes Mellitus, Type 2; Diazoxide; Female; Humans; Hypoglycemia; Insulinoma; Vasodilator Ag

2006
Continuous glucose monitoring in patients with insulinoma.
    Clinical endocrinology, 2008, Volume: 68, Issue:6

    Topics: Adult; Aged; Antihypertensive Agents; Antineoplastic Agents, Hormonal; Blood Glucose; Diazoxide; Fem

2008
Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney.
    Diabetes, 1984, Volume: 33, Issue:1

    Topics: Adenoma, Islet Cell; Animals; Cytochalasin B; Diazoxide; Glucagon; Glucose; Glyceraldehyde; Humans;

1984
Anesthesia for patients with insulinoma treatment with oral diazoxide.
    Anesthesiology, 1981, Volume: 55, Issue:4

    Topics: Adenoma, Islet Cell; Administration, Oral; Aged; Anesthesia; Diazoxide; Enflurane; Female; Humans; I

1981
Medical treatment of insulinoma.
    Acta clinica Belgica, 1981, Volume: 36, Issue:4

    Topics: Adenoma, Islet Cell; Antineoplastic Agents; Diazoxide; Humans; Insulinoma; Pancreatic Neoplasms

1981
Diazoxide treatment of canine insulinoma.
    The Veterinary record, 1981, Aug-29, Volume: 109, Issue:9

    Topics: Adenoma, Islet Cell; Administration, Oral; Animals; Blood Glucose; Diazoxide; Dog Diseases; Dogs; In

1981
[Occult insulinoma. New prospects for the therapeutic approach].
    Minerva chirurgica, 1981, Nov-15, Volume: 36, Issue:21

    Topics: Adenoma, Islet Cell; Diazoxide; Humans; Insulinoma; Pancreatic Neoplasms

1981
Diazoxide infusion test in patients with single benign insulinoma.
    Hormone research, 1983, Volume: 17, Issue:3

    Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; Diazoxide; Glucagon; Humans; Insulin; Insulinoma; K

1983
[Therapy of hypoglycemia in the adult].
    Deutsche medizinische Wochenschrift (1946), 1983, Jul-08, Volume: 108, Issue:27

    Topics: Adenoma, Islet Cell; Adult; Diazoxide; Glucagon; Glucose; Humans; Hypoglycemia; Injections, Intraven

1983
Increased mitochondrial glycerol phosphate dehydrogenase activity in insulinomas of two hypoglycemic infants.
    The Journal of clinical endocrinology and metabolism, 1983, Volume: 57, Issue:3

    Topics: Adenoma, Islet Cell; Diazoxide; Female; Glycerolphosphate Dehydrogenase; Humans; Hypoglycemia; Infan

1983
[Insulinoma: contribution of 21 cases].
    Minerva chirurgica, 1984, Feb-15, Volume: 39, Issue:3

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Diazoxide; Female; Humans; Insulinoma; Male; Middle Ag

1984
Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors.
    European journal of pharmacology, 1994, Sep-01, Volume: 262, Issue:1-2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Affinity Labels;

1994
Relapse of medically treated insulinoma following the development of thyrotoxicosis: an assessment of potential mechanisms.
    Thyroid : official journal of the American Thyroid Association, 1994,Spring, Volume: 4, Issue:1

    Topics: Aged; C-Peptide; Diazoxide; Female; Humans; Hypoglycemia; Insulin; Insulin Resistance; Insulinoma; P

1994
[The effect of Proglicem in patients with an organic hyperinsulinism syndrome].
    Casopis lekaru ceskych, 1994, Jan-17, Volume: 133, Issue:2

    Topics: Adult; Aged; Diazoxide; Female; Humans; Hyperinsulinism; Insulinoma; Male; Middle Aged; Pancreatic N

1994
Activation of potassium channels by diazoxide and cromakalim in insulin-secreting cells is dependent upon internal ADP and channel run-down.
    Biochemical Society transactions, 1993, Volume: 21, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cell Line; Cromakalim; Diazoxid

1993
Insulin action in patients with insulinoma influenced by pharmacological and surgical therapy.
    Experimental and clinical endocrinology, 1993, Volume: 101, Issue:6

    Topics: Adult; Aged; Blood Glucose; Diazoxide; Female; Humans; Hyperinsulinism; Insulin; Insulin Resistance;

1993
Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells.
    Diabetes, 1993, Volume: 42, Issue:12

    Topics: Adenosine Triphosphate; Animals; Binding Sites; Binding, Competitive; Diazoxide; Glucagon; Glucagono

1993
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
    The Journal of clinical investigation, 1993, Volume: 92, Issue:4

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne

1993
Glucose stimulates voltage- and calcium-dependent inositol trisphosphate production and intracellular calcium mobilization in insulin-secreting beta TC3 cells.
    The Biochemical journal, 1996, Feb-15, Volume: 314 ( Pt 1)

    Topics: Animals; Calcium; Calcium Channels; Diazoxide; Glucose; Inositol 1,4,5-Trisphosphate; Inositol Phosp

1996
Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1.
    Diabetologia, 1997, Volume: 40, Issue:4

    Topics: Animals; Arginine; Calcium; Cell Line; Cytosol; Diazoxide; Homoarginine; Insulin; Insulin Secretion;

1997
RIN14B: a pancreatic delta-cell line that maintains functional ATP-dependent K+ channels and capability to secrete insulin under conditions where it no longer secretes somatostatin.
    FEBS letters, 1997, Jul-14, Volume: 411, Issue:2-3

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Diazoxide; Electrophysiology; Insulin; Insul

1997
Diazoxide treatment for insulinoma: a national UK survey.
    Postgraduate medical journal, 1997, Volume: 73, Issue:864

    Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Diazoxide; Female; Health Care Surveys; Hum

1997
ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line.
    Diabetes, 1999, Volume: 48, Issue:12

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Benzofurans; C

1999
Metabolic and K(ATP) channel-independent actions of keto acid initiators of insulin secretion.
    Pancreas, 2000, Volume: 20, Issue:1

    Topics: Animals; Arginine; Butyrates; Calcium; Calcium Channel Blockers; Calcium Channels; Coumaric Acids; D

2000
Interaction of sulfonylurea-conjugated polymer with insulinoma cell line of MIN6 and its effect on insulin secretion.
    Journal of biomedical materials research, 2001, Volume: 55, Issue:1

    Topics: Acrylic Resins; Animals; Biocompatible Materials; Culture Media, Conditioned; Diazoxide; Glucose; Gl

2001
Management of hyperinsulinemia with diazoxide in an elderly hemodialysis patient.
    Nephron, 2001, Volume: 89, Issue:3

    Topics: Aged; Aged, 80 and over; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Insulinoma; Nutrition Dis

2001
TMB-8 (8-(N,N-diethylamino) octyl-3,4,5-trimethoxybenzoate) inhibits the ATP-sensitive K+ channel.
    European journal of pharmacology, 1992, Jun-05, Volume: 226, Issue:2

    Topics: Adenosine Triphosphate; Calcium Channel Blockers; Diazoxide; Electrophysiology; Gallic Acid; Insulin

1992
Chlorpromazine and related phenothiazines inhibit the ATP-sensitive K+ channel.
    European journal of pharmacology, 1991, May-30, Volume: 198, Issue:1

    Topics: Adenosine Triphosphate; Antipsychotic Agents; Chlorpromazine; Diazoxide; Electrophysiology; Insulino

1991
[Organic hyperinsulinism. Clinical aspects--diagnosis--therapy].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1991, Volume: 46, Issue:15

    Topics: Adolescent; Adult; Aged; Child; Combined Modality Therapy; Diagnosis, Differential; Diazoxide; Femal

1991
A case of insulin-secreting tumor successfully treated with diazoxide.
    The Tokai journal of experimental and clinical medicine, 1991, Volume: 16, Issue:1

    Topics: Aged; Blood Glucose; Diazoxide; Humans; Hypoglycemia; Insulin; Insulinoma; Liver; Male; Pancreatic N

1991
Evaluation of a euglycaemic clamp procedure as a diagnostic test in insulinoma patients.
    European journal of clinical investigation, 1990, Volume: 20, Issue:1

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Blood Glucose; Child; Diazoxide; Evaluation Studies as

1990
Effects of pinacidil, RP 49356 and nicorandil on ATP-sensitive potassium channels in insulin-secreting cells.
    British journal of pharmacology, 1990, Volume: 99, Issue:3

    Topics: Adenoma, Islet Cell; Adenosine Triphosphate; Diazoxide; Glucose; Guanidines; Humans; Insulin; Insuli

1990
Use of euglycaemic clamping in evaluation of diazoxide treatment of insulinoma.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:2

    Topics: Adenoma, Islet Cell; Adult; Aged; Aged, 80 and over; Blood Glucose; Diazoxide; Female; Glucose; Home

1989
[Hypoglycemic insular tumor or insulinoma].
    Revue de l'infirmiere, 1986, Volume: 36, Issue:1

    Topics: Adenoma, Islet Cell; Diazoxide; Humans; Hypoglycemia; Insulinoma; Nervous System Diseases; Pancreate

1986
Diazoxide in the management of patients with insulinoma.
    World journal of surgery, 1986, Volume: 10, Issue:4

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Child, Preschool; Diazoxide; Edema; Female; Hir

1986
Ineffectiveness of SMS 201-995 in severe hyperinsulinemia.
    Diabetes care, 1988, Volume: 11, Issue:8

    Topics: Aged; Blood Glucose; Diazoxide; Female; Humans; Hyperinsulinism; Insulin; Insulinoma; Middle Aged; O

1988