diazoxide has been researched along with Insulinoma in 74 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diazoxide is recognized as an effective medical treatment for insulinoma." | 7.91 | Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide. ( Hashimoto, K; Izumiyama, H; Kudo, A; Minami, I; Niitsu, Y; Ogawa, Y; Ota, K; Satou, F; Tanabe, M; Tsujino, M; Yamada, T; Yoshimoto, T, 2019) |
| " The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia." | 7.81 | Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide. ( Aso, Y; Hiraishi, H; Kojima, M; Shimizu, M; Suzuki, K; Tsuchida, K, 2015) |
| " We diagnosed her with insulinoma and initiated diazoxide treatment to prevent hypoglycemia." | 7.80 | Thrombocytopenia induced by diazoxide in a patient with an insulinoma. ( Adachi, J; Kakihana, K; Mimura, M; Minami, I; Watanabe, T, 2014) |
| "A survey of UK patients receiving the drug diazoxide, revealed 40 patients with insulinoma on this treatment." | 7.69 | Diazoxide treatment for insulinoma: a national UK survey. ( Gill, GV; MacFarlane, IA; Rauf, O, 1997) |
| "The use of diazoxide in patients with insulinoma has been evaluated using the euglycaemic clamp technique." | 7.67 | Use of euglycaemic clamping in evaluation of diazoxide treatment of insulinoma. ( Páv, J; Skrha, J; Srámková, J; Svacina, S, 1989) |
| "Surgery is the ideal treatment of insulinoma." | 5.72 | Preoperative treatment of benign insulinoma: diazoxide or somatostatin analogues? ( Bertrand, C; Donckier, JE; Gilliaux, Q; Hanon, F, 2022) |
| " Although patients with hyperinsulinemic hypoglycemia worldwide have been treated with diazoxide for more than 30 years, there are no recent reports about the adverse effects of this drug in Asian patients, including Japanese patients." | 5.43 | Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( Inoue, Y; Komatsu, Y; Miyoshi, H; Nakamura, A; Tajima, K; Takano, T; Takihata, M; Terauchi, Y; Tsuchiya, H; Yahagi, S; Yamakawa, T; Yoshida, M, 2016) |
| "Insulinomas are islet cell tumors of the pancreas that produce hypoglycemia due to inappropriate insulin secretion." | 5.32 | [Treatment of insulinoma with diazoxide]. ( Cristino, A; Fainstein, D; González Pardo, FO; Lasdica, S; Mateu, MV, 2003) |
| "Thus, alpha-TC glucagonoma cells contain ATP-sensitive K+ channels that regulate glucagon release, yet allow inhibition of hormone release by glucose." | 5.29 | Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells. ( Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P, 1993) |
| " Medical control of the hormonal syndrome with agents such as diazoxide for insulinoma, omeprazole for gastrinoma, and octreotide for vipoma and glucagonoma allows an orderly and thorough investigation for associated endocrinopathies and comorbid medical conditions." | 4.79 | Islet cell tumors. ( Stabile, BE, 1997) |
| "Diazoxide is recognized as an effective medical treatment for insulinoma." | 3.91 | Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide. ( Hashimoto, K; Izumiyama, H; Kudo, A; Minami, I; Niitsu, Y; Ogawa, Y; Ota, K; Satou, F; Tanabe, M; Tsujino, M; Yamada, T; Yoshimoto, T, 2019) |
| " The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia." | 3.81 | Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide. ( Aso, Y; Hiraishi, H; Kojima, M; Shimizu, M; Suzuki, K; Tsuchida, K, 2015) |
| " We diagnosed her with insulinoma and initiated diazoxide treatment to prevent hypoglycemia." | 3.80 | Thrombocytopenia induced by diazoxide in a patient with an insulinoma. ( Adachi, J; Kakihana, K; Mimura, M; Minami, I; Watanabe, T, 2014) |
| "Diazoxide treatment for presumptive insulinoma was started at a dosage of 5 mg/kg (2." | 3.79 | Diagnosis and treatment of an insulinoma in a guinea pig (Cavia porcellus). ( Hess, LR; Ravich, ML; Reavill, DR, 2013) |
| "In conclusion, this case may suggest that biologic behavior may differ from histological behavior in insulinoma and platin-based systemic chemotherapy may provide some benefit in patients those who had diazoxide- and octreotide-resistant tumors." | 3.76 | Rapidly progressing malignant insulinoma presented with multiple liver metastases: a case report. ( Akkaya, H; Askin, E; Bascil Tutuncu, N; Erdogan, A; Fatih, K; Hampar, A; Kose, F; Ozgur, O; Ozyilkan, O; Tutuncu, NB, 2010) |
| "Organic hyperinsulinism is treated as a rule conservatively with diazoxide (Proglicem) which has a hyperglycaemic effect." | 3.69 | [The effect of Proglicem in patients with an organic hyperinsulinism syndrome]. ( Justová, V; Sindelka, G; Skrha, J; Svacina, S; Wichterle, D, 1994) |
| " We describe a 72-year-old lady who initially presented with episodic hypoglycemia secondary to an insulinoma that was controlled by diazoxide." | 3.69 | Relapse of medically treated insulinoma following the development of thyrotoxicosis: an assessment of potential mechanisms. ( Alberti, KG; Kendall-Taylor, P; Trajano, LR; Walker, M, 1994) |
| "The effect on insulin release of efaroxan, an alpha 2-adrenoceptor antagonist and a highly potent drug at imidazoline I1 receptors, and the effects of seven other imidazoline compounds selective for the imidazoline I1 or I2 receptors, were studied in the rat insulinoma cell line RIN-5AH." | 3.69 | Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors. ( Haque, M; Kulkarni, RN; MacDermot, J; Olmos, G, 1994) |
| "A survey of UK patients receiving the drug diazoxide, revealed 40 patients with insulinoma on this treatment." | 3.69 | Diazoxide treatment for insulinoma: a national UK survey. ( Gill, GV; MacFarlane, IA; Rauf, O, 1997) |
| "We studied the release of insulin, glucagon, and somatostatin in response to glucose, glyceraldehyde (GA), and alpha-ketoisocaproate (KIC) from rat kidneys containing transplanted insulinomas." | 3.67 | Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney. ( Ferguson, DC; Hoenig, M; Matschinsky, FM, 1984) |
| "The use of diazoxide in patients with insulinoma has been evaluated using the euglycaemic clamp technique." | 3.67 | Use of euglycaemic clamping in evaluation of diazoxide treatment of insulinoma. ( Páv, J; Skrha, J; Srámková, J; Svacina, S, 1989) |
| " The enzyme in the insulinomas, but not that in the nearby pancreases, was inhibited by diazoxide, which is a known inhibitor of insulin secretion in vitro and in vivo." | 3.66 | Increased mitochondrial glycerol phosphate dehydrogenase activity in insulinomas of two hypoglycemic infants. ( MacDonald, MJ; Pellett, JR; Warner, TF, 1983) |
| "Hypoglycemia was not repeated on endocrinological examination, even while fasting." | 1.72 | Diagnosis and Treatment Course of Insulinoma Presenting as Hypoglycemia Unawareness Using a Factory-Calibrated Continuous Glucose Monitoring System. ( Aida, A; Noto, H, 2022) |
| "Surgery is the ideal treatment of insulinoma." | 1.72 | Preoperative treatment of benign insulinoma: diazoxide or somatostatin analogues? ( Bertrand, C; Donckier, JE; Gilliaux, Q; Hanon, F, 2022) |
| "Insulinomas are the most common cause of EHH." | 1.56 | Changing Insulinoma Management Due to Incidentally Discovered Metastasis: A Case Report. ( Chow, LS; Froelich, J; Madan, R; Mettler, T, 2020) |
| "Nesidioblastosis is a rare cause of adult hypoglycemia." | 1.51 | A Case Report of Insulinoma Relapse on Background Nesidioblastosis: A Rare Cause of Adult Hypoglycemia. ( Bonora, E; Castelli, C; Dauriz, M; Ferdeghini, M; Fuini, A; Landoni, L; Malleo, G; Maneschi, C; Moghetti, P; Tomezzoli, A, 2019) |
| "Most cases of insulinomas are benign." | 1.43 | A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma. ( Berberabe, A; Pagsisihan, D; Palugod-Lopez, EG; Sandoval, MA, 2016) |
| " Although patients with hyperinsulinemic hypoglycemia worldwide have been treated with diazoxide for more than 30 years, there are no recent reports about the adverse effects of this drug in Asian patients, including Japanese patients." | 1.43 | Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( Inoue, Y; Komatsu, Y; Miyoshi, H; Nakamura, A; Tajima, K; Takano, T; Takihata, M; Terauchi, Y; Tsuchiya, H; Yahagi, S; Yamakawa, T; Yoshida, M, 2016) |
| "Insulinomas are β-cell tumors that cause hypoglycemia through inappropriate secretion of insulin." | 1.42 | Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro. ( Guiot, Y; Henquin, JC; Nenquin, M; Rahier, J; Sempoux, C, 2015) |
| "Malignant insulinoma is an infrequent functional endocrine tumor of the pancreas." | 1.39 | Management of malignant insulinoma. ( Caballero-Díaz, C; Camps Herrero, C; Civera-Andrés, M; Ferrer-García, JC; Iranzo González-Cruz, V; Merchante-Alfaro, A; Morillas-Ariño, C; Navas-DeSolís, S; Sánchez-Juan, C, 2013) |
| "CGM in insulinoma is useful in detecting hypoglycaemia, and hypoglycaemia unawareness, monitoring response to medical therapy and for confirming cure postoperatively, and is useful in the management of this uncommon but dangerous condition." | 1.35 | Continuous glucose monitoring in patients with insulinoma. ( Choudhary, P; Harrison, B; Heller, S; Munir, A; Newell-Price, J, 2008) |
| "The treatment with diazoxide or infection of ORP150 antisense adenovirus suppressed ORP150 expression, and glucose-stimulated insulin secretion was effectively prevented." | 1.33 | 150-kD oxygen-regulated protein is an essential factor for insulin release. ( Kobayashi, T; Ohta, Y, 2005) |
| "Although insulinoma is rare in the elderly and exceedingly rare in the context of type 2 diabetes, it should be given due consideration when no other exacerbating factor is found." | 1.33 | A mysterious case of normalising blood sugar: insulinoma in a long-standing diabetic patient. ( Hameed, MF; Hoyle, GE; Muir, Z, 2006) |
| "Insulinomas are islet cell tumors of the pancreas that produce hypoglycemia due to inappropriate insulin secretion." | 1.32 | [Treatment of insulinoma with diazoxide]. ( Cristino, A; Fainstein, D; González Pardo, FO; Lasdica, S; Mateu, MV, 2003) |
| " By applying the patch-clamp technique, dose-response curves for ATP and the sulfonylurea tolbutamide were obtained in inside-out patches." | 1.30 | RIN14B: a pancreatic delta-cell line that maintains functional ATP-dependent K+ channels and capability to secrete insulin under conditions where it no longer secretes somatostatin. ( Berggren, PO; Bränström, R; Höög, A; Larsson, O; Wahl, MA, 1997) |
| "Thus, alpha-TC glucagonoma cells contain ATP-sensitive K+ channels that regulate glucagon release, yet allow inhibition of hormone release by glucose." | 1.29 | Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells. ( Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P, 1993) |
| "Chlorpromazine inhibition was observed when KATP channels were activated by ATP depletion or by direct treatment with a classical KATP channel opener, diazoxide." | 1.28 | Chlorpromazine and related phenothiazines inhibit the ATP-sensitive K+ channel. ( De Weille, JR; Lazdunski, M; Müller, M, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (22.97) | 18.7374 |
| 1990's | 20 (27.03) | 18.2507 |
| 2000's | 14 (18.92) | 29.6817 |
| 2010's | 19 (25.68) | 24.3611 |
| 2020's | 4 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Aida, A | 1 |
| Noto, H | 1 |
| Gilliaux, Q | 1 |
| Bertrand, C | 1 |
| Hanon, F | 1 |
| Donckier, JE | 1 |
| Madan, R | 1 |
| Mettler, T | 1 |
| Froelich, J | 1 |
| Chow, LS | 1 |
| Sileo, F | 1 |
| Cangiano, B | 1 |
| Cacciatore, C | 1 |
| Amarù, J | 1 |
| Gatto, F | 1 |
| Albertelli, M | 1 |
| Falconi, M | 1 |
| Vitale, G | 1 |
| Persani, L | 1 |
| Niitsu, Y | 1 |
| Minami, I | 2 |
| Izumiyama, H | 1 |
| Hashimoto, K | 1 |
| Yoshimoto, T | 1 |
| Satou, F | 1 |
| Tsujino, M | 1 |
| Ota, K | 1 |
| Kudo, A | 1 |
| Tanabe, M | 1 |
| Yamada, T | 1 |
| Ogawa, Y | 1 |
| Dauriz, M | 1 |
| Maneschi, C | 1 |
| Castelli, C | 1 |
| Tomezzoli, A | 1 |
| Fuini, A | 1 |
| Landoni, L | 1 |
| Malleo, G | 1 |
| Ferdeghini, M | 1 |
| Bonora, E | 1 |
| Moghetti, P | 1 |
| Ferrer-García, JC | 1 |
| Iranzo González-Cruz, V | 1 |
| Navas-DeSolís, S | 1 |
| Civera-Andrés, M | 1 |
| Morillas-Ariño, C | 1 |
| Merchante-Alfaro, A | 1 |
| Caballero-Díaz, C | 1 |
| Sánchez-Juan, C | 1 |
| Camps Herrero, C | 1 |
| Dall, M | 1 |
| Calloe, K | 1 |
| Haupt-Jorgensen, M | 1 |
| Larsen, J | 1 |
| Schmitt, N | 1 |
| Josefsen, K | 1 |
| Buschard, K | 1 |
| Tabarin, A | 1 |
| Goichot, B | 1 |
| Luppi, P | 1 |
| Drain, P | 1 |
| Adachi, J | 1 |
| Mimura, M | 1 |
| Kakihana, K | 1 |
| Watanabe, T | 1 |
| Shimizu, M | 1 |
| Suzuki, K | 1 |
| Tsuchida, K | 1 |
| Kojima, M | 1 |
| Hiraishi, H | 1 |
| Aso, Y | 1 |
| Henquin, JC | 1 |
| Nenquin, M | 1 |
| Guiot, Y | 1 |
| Rahier, J | 1 |
| Sempoux, C | 1 |
| Komatsu, Y | 1 |
| Nakamura, A | 1 |
| Takihata, M | 1 |
| Inoue, Y | 1 |
| Yahagi, S | 1 |
| Tajima, K | 1 |
| Tsuchiya, H | 1 |
| Takano, T | 1 |
| Yamakawa, T | 1 |
| Yoshida, M | 1 |
| Miyoshi, H | 1 |
| Terauchi, Y | 1 |
| Sandoval, MA | 1 |
| Pagsisihan, D | 1 |
| Berberabe, A | 1 |
| Palugod-Lopez, EG | 1 |
| Tomohiro, S | 1 |
| Yonemura, K | 1 |
| Okuya, T | 1 |
| Ominato, T | 1 |
| Takano, R | 1 |
| Suzuki, T | 1 |
| Kato, M | 1 |
| Shao, Y | 1 |
| Qu, YQ | 1 |
| Wang, XL | 1 |
| Song, ZG | 1 |
| Guo, QH | 1 |
| Dou, JT | 1 |
| Ba, JM | 1 |
| Lü, ZH | 1 |
| Mu, YM | 1 |
| Erdogan, A | 1 |
| Askin, E | 1 |
| Kose, F | 1 |
| Fatih, K | 1 |
| Akkaya, H | 1 |
| Hampar, A | 1 |
| Bascil Tutuncu, N | 1 |
| Tutuncu, NB | 1 |
| Ozyilkan, O | 1 |
| Ozgur, O | 1 |
| Heimann, E | 1 |
| Jones, HA | 1 |
| Resjö, S | 1 |
| Manganiello, VC | 1 |
| Stenson, L | 1 |
| Degerman, E | 1 |
| Ross, JJ | 1 |
| Vaidya, A | 1 |
| Kaiser, UB | 1 |
| Swaminathan, K | 1 |
| Young, R | 1 |
| Reid, W | 1 |
| Levy, MJ | 1 |
| Thompson, GB | 1 |
| Topazian, MD | 1 |
| Callstrom, MR | 1 |
| Grant, CS | 1 |
| Vella, A | 1 |
| Hess, LR | 1 |
| Ravich, ML | 1 |
| Reavill, DR | 1 |
| MacDonald, PE | 1 |
| Sewing, S | 1 |
| Wang, J | 2 |
| Joseph, JW | 1 |
| Smukler, SR | 1 |
| Sakellaropoulos, G | 1 |
| Saleh, MC | 1 |
| Chan, CB | 1 |
| Tsushima, RG | 1 |
| Salapatek, AM | 1 |
| Wheeler, MB | 1 |
| Mateu, MV | 1 |
| González Pardo, FO | 1 |
| Cristino, A | 1 |
| Lasdica, S | 1 |
| Fainstein, D | 1 |
| LUNDVALL, O | 1 |
| JOHNSSON, S | 1 |
| MARKS, V | 1 |
| ROSE, FC | 1 |
| SAMOLS, E | 1 |
| Merglen, A | 1 |
| Theander, S | 1 |
| Rubi, B | 1 |
| Chaffard, G | 1 |
| Wollheim, CB | 1 |
| Maechler, P | 1 |
| Park, KH | 3 |
| Akaike, T | 2 |
| Arita, Y | 1 |
| Ito, T | 1 |
| Kobayashi, T | 1 |
| Ohta, Y | 1 |
| Yang, W | 1 |
| Yang, G | 1 |
| Jia, X | 1 |
| Wu, L | 1 |
| Wang, R | 1 |
| Arao, T | 1 |
| Okada, Y | 1 |
| Hirose, A | 1 |
| Tanaka, Y | 1 |
| Hameed, MF | 1 |
| Hoyle, GE | 1 |
| Muir, Z | 1 |
| Munir, A | 1 |
| Choudhary, P | 1 |
| Harrison, B | 1 |
| Heller, S | 1 |
| Newell-Price, J | 1 |
| Turner, RC | 1 |
| Dick, R | 1 |
| Lee, EC | 1 |
| Hoenig, M | 1 |
| Ferguson, DC | 1 |
| Matschinsky, FM | 2 |
| Burch, PG | 1 |
| McLeskey, CH | 1 |
| Haemers, S | 1 |
| Rottiers, R | 1 |
| Parker, AJ | 1 |
| Musselman, EM | 1 |
| O'Brien, D | 1 |
| Calzoni, D | 1 |
| Guarneri, A | 1 |
| Santamaria, A | 1 |
| Tamburrano, G | 1 |
| Lala, A | 1 |
| Mauceri, M | 1 |
| Leonetti, F | 1 |
| Libianchi, S | 1 |
| Andreani, D | 1 |
| Berger, M | 1 |
| Tsotsalas, M | 1 |
| MacDonald, MJ | 1 |
| Warner, TF | 1 |
| Pellett, JR | 1 |
| Paletto, AE | 1 |
| Morino, F | 1 |
| Boltri, F | 1 |
| Camandona, M | 1 |
| Robecchi, A | 1 |
| Olmos, G | 1 |
| Kulkarni, RN | 1 |
| Haque, M | 1 |
| MacDermot, J | 1 |
| Walker, M | 1 |
| Trajano, LR | 1 |
| Alberti, KG | 1 |
| Kendall-Taylor, P | 1 |
| Sindelka, G | 1 |
| Skrha, J | 3 |
| Svacina, S | 2 |
| Justová, V | 2 |
| Wichterle, D | 1 |
| Jaggar, JH | 1 |
| Harding, EA | 1 |
| Ayton, BA | 1 |
| Dunne, MJ | 3 |
| Hilgertová, J | 1 |
| Ronner, P | 1 |
| Hang, TL | 1 |
| Epstein, AJ | 1 |
| Buettger, C | 1 |
| Sjöholm, A | 1 |
| Arkhammar, P | 1 |
| Welsh, N | 1 |
| Bokvist, K | 1 |
| Rorsman, P | 1 |
| Hallberg, A | 1 |
| Nilsson, T | 1 |
| Welsh, M | 1 |
| Berggren, PO | 2 |
| Gromada, J | 1 |
| Frøkjaer-Jensen, J | 1 |
| Dissing, S | 1 |
| Weinhaus, AJ | 1 |
| Poronnik, P | 1 |
| Tuch, BE | 1 |
| Cook, DI | 1 |
| Bränström, R | 1 |
| Höög, A | 1 |
| Wahl, MA | 1 |
| Larsson, O | 1 |
| Stabile, BE | 1 |
| Gill, GV | 1 |
| Rauf, O | 1 |
| MacFarlane, IA | 1 |
| Chapman, JC | 1 |
| McClenaghan, NH | 2 |
| Cosgrove, KE | 1 |
| Hashmi, MN | 1 |
| Shepherd, RM | 1 |
| Giesberts, AN | 1 |
| White, SJ | 1 |
| Ammälä, C | 1 |
| Flatt, PR | 2 |
| Kim, SW | 1 |
| Bae, YH | 1 |
| Shaer, AJ | 1 |
| Szewczyk, A | 1 |
| De Weille, JR | 2 |
| Lazdunski, M | 2 |
| Müller, M | 1 |
| Ulrich, FE | 1 |
| Schneyer, U | 1 |
| Hädecke, J | 1 |
| Takeda, H | 1 |
| Watanabe, K | 1 |
| Suzuki, D | 1 |
| Miyano, R | 1 |
| Tanaka, K | 1 |
| Machimura, H | 1 |
| Yagame, M | 1 |
| Inoue, W | 1 |
| Kaneshige, H | 1 |
| Sakai, H | 1 |
| Nauck, M | 1 |
| Stöckmann, F | 1 |
| Creutzfeldt, W | 1 |
| Meleo, K | 1 |
| Srámková, J | 1 |
| Páv, J | 1 |
| Bahloul, F | 1 |
| Goode, PN | 1 |
| Farndon, JR | 1 |
| Anderson, J | 1 |
| Johnston, ID | 1 |
| Morte, JA | 1 |
| Boden, G | 1 |
| Ryan, IG | 1 |
| Shuman, CR | 1 |
| Nelson, RW | 1 |
| Foodman, MS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for diazoxide and Insulinoma
| Article | Year |
|---|---|
[Diagnosis and treatment of insulinoma].
Topics: Antineoplastic Agents; Blood Glucose; Chemoembolization, Therapeutic; Diazoxide; Fasting; Glucagon; | 2004 |
[Localization of beta-Langerhans tumors secreting hypoglycemics].
Topics: Adenoma, Islet Cell; Angiography; Diazoxide; Humans; Insulin; Insulinoma; Intraoperative Period; Lap | 1983 |
Islet cell tumors.
Topics: Adenoma, Islet Cell; Diazoxide; Gastrinoma; Humans; Hypoglycemia; Insulinoma; Octreotide; Pancreatic | 1997 |
Management of insuloma patients with refractory hypoglycemia.
Topics: Animals; Diazoxide; Dog Diseases; Dogs; Glucocorticoids; Hypoglycemia; Insulinoma; Prognosis; Somato | 1990 |
Medical management of canine hyperinsulinism.
Topics: Adrenal Cortex Hormones; Animals; Blood Glucose; Combined Modality Therapy; Diazoxide; Diet Therapy; | 1985 |
69 other studies available for diazoxide and Insulinoma
| Article | Year |
|---|---|
Diagnosis and Treatment Course of Insulinoma Presenting as Hypoglycemia Unawareness Using a Factory-Calibrated Continuous Glucose Monitoring System.
Topics: Adult; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Complications; Diazoxide; Humans; Hype | 2022 |
Preoperative treatment of benign insulinoma: diazoxide or somatostatin analogues?
Topics: Adult; Diazoxide; Humans; Insulinoma; Octreotide; Pancreatic Neoplasms; Somatostatin | 2022 |
Changing Insulinoma Management Due to Incidentally Discovered Metastasis: A Case Report.
Topics: Ablation Techniques; Bone Neoplasms; Diagnosis, Differential; Diazoxide; Endosonography; Female; Hum | 2020 |
Off-label pasireotide treatment in one insulinoma patient with an atypical presentation and intolerant to diazoxide.
Topics: Diazoxide; Humans; Insulinoma; Off-Label Use; Pancreatic Neoplasms; Somatostatin | 2020 |
Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Diazoxide; Female; Humans; Insuli | 2019 |
A Case Report of Insulinoma Relapse on Background Nesidioblastosis: A Rare Cause of Adult Hypoglycemia.
Topics: Diazoxide; Female; Humans; Hypoglycemia; Insulinoma; Middle Aged; Neoplasm Recurrence, Local; Nesidi | 2019 |
Management of malignant insulinoma.
Topics: Adult; Aged; Chemoembolization, Therapeutic; Diazoxide; Everolimus; Female; Glucocorticoids; Humans; | 2013 |
Gliadin fragments and a specific gliadin 33-mer peptide close KATP channels and induce insulin secretion in INS-1E cells and rat islets of langerhans.
Topics: Action Potentials; Amino Acid Sequence; Animals; Blood Glucose; Body Weight; Cell Line; Cell Line, T | 2013 |
Treatment: symptomatic treatment of hypoglycaemia.
Topics: Antineoplastic Agents; Blood Glucose; Diazoxide; Everolimus; Humans; Hypoglycemia; Insulinoma; Octre | 2013 |
Autocrine C-peptide mechanism underlying INS1 beta cell adaptation to oxidative stress.
Topics: Adaptation, Physiological; Animals; Apoptosis; Autocrine Communication; C-Peptide; Cell Line, Tumor; | 2014 |
Thrombocytopenia induced by diazoxide in a patient with an insulinoma.
Topics: Biopsy; Diagnosis, Differential; Diazoxide; Female; Humans; Insulinoma; Pancreatic Neoplasms; Thromb | 2014 |
Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide.
Topics: Antihypertensive Agents; Biomarkers, Tumor; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Dia | 2015 |
Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro.
Topics: Adult; Aged, 80 and over; Calcium Chloride; Diazoxide; Female; Gene Expression Regulation; Glucose; | 2015 |
Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Diazoxide; Drug Monitoring; Drug Resistance; Edema | 2016 |
A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma.
Topics: Biopsy; Blood Glucose; C-Peptide; Carcinoma, Neuroendocrine; Diazoxide; Humans; Hyperinsulinism; Hyp | 2016 |
[Case Report; A case of geriatric insulinoma successfully treated by diazoxide].
Topics: Aged, 80 and over; Diazoxide; Humans; Insulinoma; Male; Treatment Outcome | 2014 |
Malignant insulinoma: Report of 6 patients and literature review.
Topics: Adult; Diazoxide; Diuretics; Female; Humans; Hypoglycemia; Insulinoma; Liver Neoplasms; Male; Middle | 2016 |
Rapidly progressing malignant insulinoma presented with multiple liver metastases: a case report.
Topics: Antineoplastic Agents; Diazoxide; Fatal Outcome; Female; Humans; Insulinoma; Liver Neoplasms; Middle | 2010 |
Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets.
Topics: Animals; Cell Line, Tumor; Cyclic Nucleotide Phosphodiesterases, Type 3; Diazoxide; Gene Expression | 2010 |
Interactive medical case. Lying low.
Topics: Aged, 80 and over; Confusion; Diazoxide; Dizziness; Female; Humans; Hypoglycemia; Insulinoma; Magnet | 2011 |
The diagnosis was in her birthday party!
Topics: Aged, 80 and over; Blood Glucose; C-Peptide; Confusion; Diazoxide; Epilepsy, Tonic-Clonic; Female; H | 2012 |
US-guided ethanol ablation of insulinomas: a new treatment option.
Topics: Ablation Techniques; Adult; Aged; Aged, 80 and over; Blood Glucose; Diazoxide; Endosonography; Ethan | 2012 |
Diagnosis and treatment of an insulinoma in a guinea pig (Cavia porcellus).
Topics: Animals; Antihypertensive Agents; Blood Glucose; Diazoxide; Guinea Pigs; Insulinoma; Male; Pancreati | 2013 |
Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.
Topics: Animals; Calcium; Calcium Channel Blockers; Delayed Rectifier Potassium Channels; Diazoxide; Female; | 2002 |
[Treatment of insulinoma with diazoxide].
Topics: Aged; Diazoxide; Humans; Insulinoma; Male; Pancreatic Neoplasms; Vasodilator Agents | 2003 |
[INSULOMA TREATED WITH DIAZOXIDE].
Topics: Adenoma, Islet Cell; Antihypertensive Agents; Chlorthalidone; Diabetes Mellitus; Diazoxide; Geriatri | 1965 |
HYPERINSULINISM DUE TO METASTASIZING INSULINOMA: TREATMENT WITH DIAZOXIDE.
Topics: Adenoma, Islet Cell; Diazoxide; Drug Therapy; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulino | 1965 |
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Differentiation; Cell Division; Cytosol; Diazoxide; E | 2004 |
Visualization of the specific interaction of sulfonylurea-incorporated polymer with insulinoma cell line MIN6.
Topics: Adenosine Triphosphate; Animals; Cell Line; Culture Media, Conditioned; Diazoxide; Dose-Response Rel | 2004 |
150-kD oxygen-regulated protein is an essential factor for insulin release.
Topics: Adenoviridae; Animals; Antisense Elements (Genetics); Cell Line, Tumor; Cromakalim; Diazoxide; Genes | 2005 |
Probing of specific binding of synthetic sulfonylurea with the insulinoma cell line MIN6.
Topics: Calcium; Diazoxide; Glyburide; Hypoglycemic Agents; Insulinoma; Microscopy, Confocal; Pancreatic Neo | 2005 |
Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Cell Line, Tumor; Cystathionine gamma-Lyase; Dia | 2005 |
A rare case of adult-onset nesidioblastosis treated successfully with diazoxide.
Topics: Angiography; Blood Glucose; Diagnosis, Differential; Diazoxide; Humans; Hyperinsulinism; Hypoglycemi | 2006 |
A mysterious case of normalising blood sugar: insulinoma in a long-standing diabetic patient.
Topics: Aged; Diabetes Mellitus, Type 2; Diazoxide; Female; Humans; Hypoglycemia; Insulinoma; Vasodilator Ag | 2006 |
Continuous glucose monitoring in patients with insulinoma.
Topics: Adult; Aged; Antihypertensive Agents; Antineoplastic Agents, Hormonal; Blood Glucose; Diazoxide; Fem | 2008 |
Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney.
Topics: Adenoma, Islet Cell; Animals; Cytochalasin B; Diazoxide; Glucagon; Glucose; Glyceraldehyde; Humans; | 1984 |
Anesthesia for patients with insulinoma treatment with oral diazoxide.
Topics: Adenoma, Islet Cell; Administration, Oral; Aged; Anesthesia; Diazoxide; Enflurane; Female; Humans; I | 1981 |
Medical treatment of insulinoma.
Topics: Adenoma, Islet Cell; Antineoplastic Agents; Diazoxide; Humans; Insulinoma; Pancreatic Neoplasms | 1981 |
Diazoxide treatment of canine insulinoma.
Topics: Adenoma, Islet Cell; Administration, Oral; Animals; Blood Glucose; Diazoxide; Dog Diseases; Dogs; In | 1981 |
[Occult insulinoma. New prospects for the therapeutic approach].
Topics: Adenoma, Islet Cell; Diazoxide; Humans; Insulinoma; Pancreatic Neoplasms | 1981 |
Diazoxide infusion test in patients with single benign insulinoma.
Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; Diazoxide; Glucagon; Humans; Insulin; Insulinoma; K | 1983 |
[Therapy of hypoglycemia in the adult].
Topics: Adenoma, Islet Cell; Adult; Diazoxide; Glucagon; Glucose; Humans; Hypoglycemia; Injections, Intraven | 1983 |
Increased mitochondrial glycerol phosphate dehydrogenase activity in insulinomas of two hypoglycemic infants.
Topics: Adenoma, Islet Cell; Diazoxide; Female; Glycerolphosphate Dehydrogenase; Humans; Hypoglycemia; Infan | 1983 |
[Insulinoma: contribution of 21 cases].
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Diazoxide; Female; Humans; Insulinoma; Male; Middle Ag | 1984 |
Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Affinity Labels; | 1994 |
Relapse of medically treated insulinoma following the development of thyrotoxicosis: an assessment of potential mechanisms.
Topics: Aged; C-Peptide; Diazoxide; Female; Humans; Hypoglycemia; Insulin; Insulin Resistance; Insulinoma; P | 1994 |
[The effect of Proglicem in patients with an organic hyperinsulinism syndrome].
Topics: Adult; Aged; Diazoxide; Female; Humans; Hyperinsulinism; Insulinoma; Male; Middle Aged; Pancreatic N | 1994 |
Activation of potassium channels by diazoxide and cromakalim in insulin-secreting cells is dependent upon internal ADP and channel run-down.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cell Line; Cromakalim; Diazoxid | 1993 |
Insulin action in patients with insulinoma influenced by pharmacological and surgical therapy.
Topics: Adult; Aged; Blood Glucose; Diazoxide; Female; Humans; Hyperinsulinism; Insulin; Insulin Resistance; | 1993 |
Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Binding, Competitive; Diazoxide; Glucagon; Glucagono | 1993 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne | 1993 |
Glucose stimulates voltage- and calcium-dependent inositol trisphosphate production and intracellular calcium mobilization in insulin-secreting beta TC3 cells.
Topics: Animals; Calcium; Calcium Channels; Diazoxide; Glucose; Inositol 1,4,5-Trisphosphate; Inositol Phosp | 1996 |
Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1.
Topics: Animals; Arginine; Calcium; Cell Line; Cytosol; Diazoxide; Homoarginine; Insulin; Insulin Secretion; | 1997 |
RIN14B: a pancreatic delta-cell line that maintains functional ATP-dependent K+ channels and capability to secrete insulin under conditions where it no longer secretes somatostatin.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Diazoxide; Electrophysiology; Insulin; Insul | 1997 |
Diazoxide treatment for insulinoma: a national UK survey.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Diazoxide; Female; Health Care Surveys; Hum | 1997 |
ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Benzofurans; C | 1999 |
Metabolic and K(ATP) channel-independent actions of keto acid initiators of insulin secretion.
Topics: Animals; Arginine; Butyrates; Calcium; Calcium Channel Blockers; Calcium Channels; Coumaric Acids; D | 2000 |
Interaction of sulfonylurea-conjugated polymer with insulinoma cell line of MIN6 and its effect on insulin secretion.
Topics: Acrylic Resins; Animals; Biocompatible Materials; Culture Media, Conditioned; Diazoxide; Glucose; Gl | 2001 |
Management of hyperinsulinemia with diazoxide in an elderly hemodialysis patient.
Topics: Aged; Aged, 80 and over; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Insulinoma; Nutrition Dis | 2001 |
TMB-8 (8-(N,N-diethylamino) octyl-3,4,5-trimethoxybenzoate) inhibits the ATP-sensitive K+ channel.
Topics: Adenosine Triphosphate; Calcium Channel Blockers; Diazoxide; Electrophysiology; Gallic Acid; Insulin | 1992 |
Chlorpromazine and related phenothiazines inhibit the ATP-sensitive K+ channel.
Topics: Adenosine Triphosphate; Antipsychotic Agents; Chlorpromazine; Diazoxide; Electrophysiology; Insulino | 1991 |
[Organic hyperinsulinism. Clinical aspects--diagnosis--therapy].
Topics: Adolescent; Adult; Aged; Child; Combined Modality Therapy; Diagnosis, Differential; Diazoxide; Femal | 1991 |
A case of insulin-secreting tumor successfully treated with diazoxide.
Topics: Aged; Blood Glucose; Diazoxide; Humans; Hypoglycemia; Insulin; Insulinoma; Liver; Male; Pancreatic N | 1991 |
Evaluation of a euglycaemic clamp procedure as a diagnostic test in insulinoma patients.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Blood Glucose; Child; Diazoxide; Evaluation Studies as | 1990 |
Effects of pinacidil, RP 49356 and nicorandil on ATP-sensitive potassium channels in insulin-secreting cells.
Topics: Adenoma, Islet Cell; Adenosine Triphosphate; Diazoxide; Glucose; Guanidines; Humans; Insulin; Insuli | 1990 |
Use of euglycaemic clamping in evaluation of diazoxide treatment of insulinoma.
Topics: Adenoma, Islet Cell; Adult; Aged; Aged, 80 and over; Blood Glucose; Diazoxide; Female; Glucose; Home | 1989 |
[Hypoglycemic insular tumor or insulinoma].
Topics: Adenoma, Islet Cell; Diazoxide; Humans; Hypoglycemia; Insulinoma; Nervous System Diseases; Pancreate | 1986 |
Diazoxide in the management of patients with insulinoma.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Child, Preschool; Diazoxide; Edema; Female; Hir | 1986 |
Ineffectiveness of SMS 201-995 in severe hyperinsulinemia.
Topics: Aged; Blood Glucose; Diazoxide; Female; Humans; Hyperinsulinism; Insulin; Insulinoma; Middle Aged; O | 1988 |