diazoxide has been researched along with Infant, Newborn, Diseases in 28 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Infant, Newborn, Diseases: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diazoxide is one such treatment that acts on the pancreatic β-cell in a dose-dependent manner to decrease insulin secretion." | 3.11 | Oral diazoxide versus placebo for severe or recurrent neonatal hypoglycaemia: Neonatal Glucose Care Optimisation (NeoGluCO) study - a randomised controlled trial. ( Alsweiler, JM; Ardern, J; Chase, JG; Cutfield, WS; Gamble, GD; Hanning, SM; Harding, JE; Laing, D; McKinlay, CJ; Meyer, MP; Rogers, J; Walsh, E, 2022) |
| "Treatment with diazoxide and chlorthiazide is highly effective, appears to be safe, and does not need to be continued lifelong." | 1.33 | Hyperinsulinism in tyrosinaemia type I. ( Baumann, U; Green, A; Kelly, DA; McKiernan, PJ; Preece, MA, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.57) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Laing, D | 1 |
| Walsh, E | 1 |
| Alsweiler, JM | 1 |
| Hanning, SM | 1 |
| Meyer, MP | 1 |
| Ardern, J | 1 |
| Cutfield, WS | 1 |
| Rogers, J | 1 |
| Gamble, GD | 1 |
| Chase, JG | 1 |
| Harding, JE | 1 |
| McKinlay, CJ | 1 |
| Solís-García, G | 1 |
| Yeung, T | 1 |
| Jasani, B | 1 |
| Begum-Hasan, J | 1 |
| Baumann, U | 1 |
| Preece, MA | 1 |
| Green, A | 1 |
| Kelly, DA | 1 |
| McKiernan, PJ | 1 |
| Lyen, KR | 1 |
| Hosoi, T | 1 |
| Inomata, H | 1 |
| Miyamoto, S | 1 |
| Sasaki, N | 1 |
| Niimi, H | 1 |
| Smith, MJ | 1 |
| Aynsley-Green, A | 2 |
| Redman, CW | 1 |
| Polak, JM | 1 |
| Bloom, SR | 1 |
| Gough, MH | 1 |
| Keeling, J | 1 |
| Ashcroft, SJ | 1 |
| Turner, RC | 1 |
| Baum, JD | 1 |
| Schiller, M | 1 |
| Krausz, M | 1 |
| Meyer, S | 1 |
| Lijovetzky, G | 1 |
| Landau, H | 1 |
| Habbick, BF | 1 |
| Cram, RW | 1 |
| Miller, KR | 1 |
| Jeschke, R | 1 |
| Romen, W | 1 |
| Thanner, F | 1 |
| Niggemeyer, H | 1 |
| Adelman, RD | 1 |
| Merten, D | 1 |
| Vogel, J | 1 |
| Goetzman, BW | 1 |
| Wennberg, RP | 1 |
| Crowder, WL | 1 |
| Maclaren, NK | 1 |
| Gutberlet, RL | 1 |
| Frost, JL | 1 |
| Mason, GR | 1 |
| Cornblath, M | 3 |
| Moncrieff, MW | 1 |
| Lacey, KA | 1 |
| Malleson, PN | 1 |
| S0vik, O | 1 |
| Vidnes, J | 1 |
| Falkmer, S | 1 |
| Dudley, DK | 1 |
| Salinas, ED | 1 |
| Mangurten, HH | 1 |
| Roberts, SS | 1 |
| Simon, WH | 1 |
| Garces, LY | 1 |
| Drash, A | 2 |
| Kenny, FM | 1 |
| Etheridge, JE | 1 |
| Kenny, F | 1 |
| Field, J | 1 |
| Blizzard, R | 1 |
| Langs, H | 1 |
| Wolff, F | 1 |
| Schwartz, JF | 1 |
| Zwiren, GT | 1 |
| Schiff, D | 2 |
| Colle, E | 1 |
| Wells, D | 1 |
| Stern, L | 1 |
| Beard, A | 1 |
| Gentz, J | 1 |
| Kellum, M | 1 |
| Persson, B | 1 |
| Zetterström, R | 1 |
| Haworth, JC | 1 |
| Fontaine, G | 1 |
| Farriaux, JP | 1 |
| Hongre, JF | 1 |
| Brown, RE | 1 |
| Young, RB | 1 |
| Greenberg, RE | 1 |
| Christiansen, RO | 1 |
2 reviews available for diazoxide and Infant, Newborn, Diseases
| Article | Year |
|---|---|
Hypoglycaemia in infancy and childhood.
Topics: Blood Glucose; Child; Child, Preschool; Diazoxide; Fasting; Glycogen Storage Disease Type I; Humans; | 1984 |
Hypoglycemia and the central nervous system.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Child, Preschool; Diazoxide; Diet Therapy; Epin | 1967 |
1 trial available for diazoxide and Infant, Newborn, Diseases
| Article | Year |
|---|---|
Oral diazoxide versus placebo for severe or recurrent neonatal hypoglycaemia: Neonatal Glucose Care Optimisation (NeoGluCO) study - a randomised controlled trial.
Topics: Blood Glucose; Diazoxide; Double-Blind Method; Female; Fetal Diseases; Glucose; Humans; Hypoglycemia | 2022 |
25 other studies available for diazoxide and Infant, Newborn, Diseases
| Article | Year |
|---|---|
Does the use of diazoxide for hyperinsulinaemic hypoglycaemia increase the risk of necrotising enterocolitis in neonates?
Topics: Diazoxide; Enterocolitis, Necrotizing; Female; Fetal Diseases; Humans; Hypoglycemia; Infant, Newborn | 2023 |
Congenital hyperinsulinemia with grade 4 intraventricular hemorrhage: a case report with a 2-year follow-up.
Topics: Angiography; Congenital Hyperinsulinism; Diazoxide; Female; Humans; Infant, Newborn; Infant, Newborn | 2014 |
Hyperinsulinism in tyrosinaemia type I.
Topics: Blood Glucose; C-Peptide; Chlorothiazide; Diazoxide; Diuretics; Humans; Hyperinsulinism; Hypoglycemi | 2005 |
[Hyperinsulinemia--a case report].
Topics: Diazoxide; Humans; Hyperinsulinism; Infant, Newborn; Infant, Newborn, Diseases; Male | 1983 |
Neonatal hyperglycaemia after prolonged maternal treatment with diazoxide.
Topics: Adult; Diazoxide; Female; Humans; Hyperglycemia; Hypertension; Infant, Newborn; Infant, Newborn, Dis | 1982 |
Nesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia.
Topics: Diazoxide; Female; Glucose; Humans; Hyperinsulinism; Hypoglycemia; In Vitro Techniques; Infant, Newb | 1981 |
Neonatal hyperinsulinism--surgical and pathologic considerations.
Topics: Diazoxide; Female; Humans; Hyperinsulinism; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male | 1980 |
Neonatal hypoglycemia resulting from islet cell adenomatosis. Successful treatment with total pancreatectomy.
Topics: Adenoma, Islet Cell; Cortisone; Diazoxide; Female; Glucose; Humans; Hypoglycemia; Infant, Newborn; I | 1977 |
[The disease pattern of the diffuse, nesidioblastic hyperplasia of the pancreatic islets in newborn and infants (author's transl)].
Topics: Adenoma, Islet Cell; Diazoxide; Fatty Acids, Nonesterified; Humans; Hydroxybutyrates; Hypoglycemia; | 1978 |
Nonsurgical management of renovascular hypertension in the neonate.
Topics: Adult; Antihypertensive Agents; Diazoxide; Diuretics; Female; Humans; Hydralazine; Hypertension, Ren | 1978 |
Neonatal pancreatic beta-cell hyperplasia: report of a case with failure of diazoxide and benefit of early subtotal pancreatectomy.
Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; Infant, Newborn; Infant, Newb | 1976 |
Management of prolonged hypoglycaemia in Beckwith's syndrome.
Topics: Abnormalities, Multiple; Adrenal Cortex Hormones; Diazoxide; Hernia, Umbilical; Humans; Hypoglycemia | 1977 |
Persistent neonatal hypoglycaemia. A clinical and histopathological study of three cases treated with diazoxide and subtotal pancreatectomy.
Topics: Biopsy; Birth Weight; Blood Glucose; Diazoxide; Female; Follow-Up Studies; Glucose Tolerance Test; H | 1975 |
Minibolus diazoxide in the management of severe hypertension in pregnancy.
Topics: Apgar Score; Birth Weight; Diazoxide; Female; Humans; Hypertension; Infant, Newborn; Infant, Newborn | 1985 |
Functioning islet cell adenoma in the newborn. Report of a case with failure of diazoxide.
Topics: Adenoma, Islet Cell; Adrenocorticotropic Hormone; Blood Glucose; Catecholamines; Corticosterone; Dia | 1968 |
Islet cell tumor in the neonate. Studies in carbohydrate metabolism and therapeutic response.
Topics: Adenoma; Adenoma, Islet Cell; Blood Glucose; Carbohydrate Metabolism; Diazoxide; Diet Therapy; Growt | 1968 |
The therapeutic application of diazoxide in pediatric hypoglycemic states.
Topics: Adenoma, Islet Cell; Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Glucose Tolerance Te | 1968 |
Islet cell adenomatosis and adenoma in an infant.
Topics: Adenoma, Islet Cell; Adrenocorticotropic Hormone; Diazoxide; Glucose; Humans; Hypoglycemia; Infant, | 1971 |
Perinatal therapeutics and toxicology.
Topics: Diazoxide; Drug-Related Side Effects and Adverse Reactions; Female; Fetus; Humans; Infant; Infant, N | 1973 |
Metabolic aspects of the Beckwith-Wiedemann syndrome.
Topics: Abnormalities, Multiple; Adrenal Gland Diseases; Blood Glucose; Child, Preschool; Diazoxide; Epineph | 1973 |
Neonatal hypoglycemia: a discussion.
Topics: Anticonvulsants; Diazoxide; Diet Therapy; Epinephrine; Female; Glucagon; Glucose; Glucose Tolerance | 1971 |
[Value of diazoxide in the treatment of neonatal hypoglycemia].
Topics: Blood Glucose; Diazoxide; Female; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; | 1972 |
A possible role for the exocrine pancreas in the pathogenesis of neonatal leucine-sensitive hypoglycemia.
Topics: Diazoxide; Exocrine Glands; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Leucin | 1970 |
The critically ill child: hypoglycemia.
Topics: Child; Diazoxide; Endocrine System Diseases; Fasting; Glucose; Humans; Hypoglycemia; Infant; Infant, | 1970 |
Idiopathic neonatal hypoglycaemia treated with diazoxide.
Topics: Diazoxide; Female; Glucagon; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Pancr | 1969 |