diazoxide has been researched along with Hypoxia in 37 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Previously, we found that diazoxide promotes myelination and attenuates brain injury in the chronic sublethal hypoxia model of PWMI." | 7.80 | Diazoxide promotes oligodendrocyte differentiation in neonatal brain in normoxia and chronic sublethal hypoxia. ( Rivkees, SA; Shi, O; Wendler, CC; Zhu, Y, 2014) |
| " To elucidate whether and how the mitoKATP channel protects against hypoxia-reoxygenation (H-R)-induced mitochondrial dysfunction in fish, we first determined the mitochondrial bioenergetic effects of two key modulators of the channel, diazoxide and 5-hydroxydecanoate (5-HD), using a wide range of doses." | 3.83 | Bioenergetic and volume regulatory effects of mitoKATP channel modulators protect against hypoxia-reoxygenation-induced mitochondrial dysfunction. ( Kamunde, C; Onukwufor, JO; Stevens, D, 2016) |
| " Previously, we found that diazoxide promotes myelination and attenuates brain injury in the chronic sublethal hypoxia model of PWMI." | 3.80 | Diazoxide promotes oligodendrocyte differentiation in neonatal brain in normoxia and chronic sublethal hypoxia. ( Rivkees, SA; Shi, O; Wendler, CC; Zhu, Y, 2014) |
| " Short periods of hypoxia (5 min) induced reproducible depolarizations which were concentration-dependently depressed by an agonist of ATP-dependent potassium (K(ATP)) channels, diazoxide (3-300 microM)." | 3.70 | Changes by short-term hypoxia in the membrane properties of pyramidal cells and the levels of purine and pyrimidine nucleotides in slices of rat neocortex; effects of agonists and antagonists of ATP-dependent potassium channels. ( Garcia de Arriba, S; Illes, P; Nieber, K; Pissarek, M; Schäfer, M; Sieler, D, 1998) |
| "The K(ATP) channel activator, diazoxide (100 microM, n=6) or hypoxia (0% O2/5% CO2, n=6) significantly attenuated the HR response to 3 Hz SNS by -10+/-4% and -27+/-6% respectively; an effect that was reversed by the K(ATP) channel inhibitor, glibenclamide (30 microM)." | 3.70 | Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation. ( Mohan, RM; Paterson, DJ, 2000) |
| "Hypoxia is the leading cause of death in cardiomyocytes." | 1.62 | Diazoxide Needs Mitochondrial Connexin43 to Exert Its Cytoprotective Effect in a Cellular Model of CoCl ( Marzocco, S; Pecoraro, M; Popolo, A, 2021) |
| "We characterized an anoxia/reoxygenation (A/R) model using freshly isolated adult rat cardiomyocytes." | 1.42 | Genome-Wide Expression Profiling of Anoxia/Reoxygenation in Rat Cardiomyocytes Uncovers the Role of MitoKATP in Energy Homeostasis. ( Cao, S; Liu, X; Liu, Y; Sun, W; Yu, T; Zhang, L; Zhao, L, 2015) |
| "Desflurane (6%) was administered during the first 5 min of reoxygenation either alone or in the presence of calphostin C (PKC inhibitor) or 5-hydroxydecanoate (5-HD) (mitoK(ATP) channel antagonist)." | 1.37 | Mechanisms involved in the desflurane-induced post-conditioning of isolated human right atria from patients with type 2 diabetes. ( Buléon, C; Galera, P; Gérard, JL; Hanouz, JL; Lemoine, S; Massetti, M; Zhu, L, 2011) |
| "Phosphorylation of p38 was augmented by anoxia in the three regions, and returned to basal level at the end of reoxygenation except in the outflow tract." | 1.36 | Transient anoxia and oxyradicals induce a region-specific activation of MAPKs in the embryonic heart. ( Gardier, S; Pedretti, S; Raddatz, E; Sarre, A, 2010) |
| "During anoxia, [Ca(2+)](c) increased 9." | 1.35 | Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle. ( Buck, LT; Cooray, M; Pamenter, ME; Shin, DS, 2008) |
| "Diazoxide prevented the increase in mitochondrial Ca(2+), mitochondrial depolarization and cytochrome c release induced by hypoxia and all these effects of diazoxide were blocked by epsilonV1-2 or 5-HD." | 1.33 | Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury. ( Ahn, JH; Baik, EJ; Jung, YS; Kim, MJ; Kim, MY; Lee, SH; Moon, CH; Yoon, IS, 2006) |
| "Pretreatment with diazoxide protected both Sur1KO and wild-type neurons, while 5-hydroxydecanoate augmented neurodegeneration in both strains of animals when administered before a 20-minute bout of ischemia." | 1.32 | Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels. ( Aguilar-Bryan, L; Barrios, R; Bryan, J; Goodman, JC; Muñoz, A; Nakazaki, M; Onetti, CG, 2003) |
| "Diazoxide was without effect on tau(open) and tau(closed,fast) but decreased significantly tau(closed,slow) (24." | 1.31 | Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells. ( Carlen, PL; Pahapill, PA; Pelletier, MR; Pennefather, PS, 2000) |
| "During tissue anoxia, elicited by superfusion of N(2)-gassed solution, the biphasic response of the respiratory activity was accompanied by a continuous rise in the IOS." | 1.31 | Intrinsic optical signals in respiratory brain stem regions of mice: neurotransmitters, neuromodulators, and metabolic stress. ( Haller, M; Mironov, SL; Richter, DW, 2001) |
| "3." | 1.28 | Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction. ( Kozlowski, RZ; Nye, PC; Robertson, BE, 1992) |
| "When diazoxide was injected with the renin extract into hypoxic nephrectomized rats, the vasopressor effect of renin was abolished for 4 hours, and the plasma Ep levels were significantly lower than those of hypoxic nephrectomized animals injected only with renin, Injection of angiotensin II into anephric, hypoxic rats had an effect comparable to that of renin on extrarenal Ep roduction." | 1.26 | Effect of renin on extrarenal erythropoietin production. ( Anagnostou, A; Baranowski, R; Fried, W; Kurtzman, N; Pillay, VK; Vercellotti, G, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (16.22) | 18.7374 |
| 1990's | 6 (16.22) | 18.2507 |
| 2000's | 15 (40.54) | 29.6817 |
| 2010's | 9 (24.32) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Pecoraro, M | 1 |
| Marzocco, S | 1 |
| Popolo, A | 1 |
| Zhu, Y | 1 |
| Wendler, CC | 1 |
| Shi, O | 1 |
| Rivkees, SA | 1 |
| Bu, HM | 1 |
| Yang, CY | 1 |
| Wang, ML | 1 |
| Ma, HJ | 1 |
| Sun, H | 1 |
| Zhang, Y | 1 |
| Cao, S | 1 |
| Liu, Y | 1 |
| Sun, W | 1 |
| Zhao, L | 1 |
| Zhang, L | 1 |
| Liu, X | 1 |
| Yu, T | 1 |
| Onukwufor, JO | 1 |
| Stevens, D | 1 |
| Kamunde, C | 1 |
| Zhang, W | 1 |
| Carreño, FR | 1 |
| Cunningham, JT | 1 |
| Mifflin, SW | 1 |
| Abdallah, Y | 1 |
| Wolf, C | 1 |
| Meuter, K | 1 |
| Piper, HM | 1 |
| Reusch, HP | 1 |
| Ladilov, Y | 1 |
| Gardier, S | 1 |
| Pedretti, S | 1 |
| Sarre, A | 2 |
| Raddatz, E | 2 |
| Liu, RG | 1 |
| Song, N | 1 |
| Li, JM | 1 |
| Cui, X | 1 |
| Chen, YQ | 1 |
| Zhang, H | 1 |
| Zhao, D | 1 |
| Wang, Z | 1 |
| Zheng, D | 1 |
| Lemoine, S | 1 |
| Zhu, L | 1 |
| Buléon, C | 1 |
| Massetti, M | 1 |
| Gérard, JL | 1 |
| Galera, P | 1 |
| Hanouz, JL | 1 |
| Neckár, J | 1 |
| Szárszoi, O | 1 |
| Koten, L | 1 |
| Papousek, F | 1 |
| Ost'ádal, B | 1 |
| Grover, GJ | 1 |
| Kolár, F | 1 |
| Muñoz, A | 1 |
| Nakazaki, M | 1 |
| Goodman, JC | 1 |
| Barrios, R | 1 |
| Onetti, CG | 1 |
| Bryan, J | 1 |
| Aguilar-Bryan, L | 1 |
| Eigel, BN | 1 |
| Gursahani, H | 1 |
| Hadley, RW | 1 |
| Lange, N | 1 |
| Kucera, P | 1 |
| Chen, J | 1 |
| Zhu, JX | 1 |
| Wilson, I | 1 |
| Cameron, JS | 1 |
| Kim, MY | 1 |
| Kim, MJ | 1 |
| Yoon, IS | 1 |
| Ahn, JH | 1 |
| Lee, SH | 1 |
| Baik, EJ | 1 |
| Moon, CH | 1 |
| Jung, YS | 1 |
| Pamenter, ME | 1 |
| Shin, DS | 1 |
| Cooray, M | 1 |
| Buck, LT | 1 |
| Reeves, WB | 1 |
| Shah, SV | 1 |
| Mironov, SL | 2 |
| Langohr, K | 1 |
| Haller, M | 2 |
| Richter, DW | 2 |
| Pissarek, M | 1 |
| Garcia de Arriba, S | 1 |
| Schäfer, M | 1 |
| Sieler, D | 1 |
| Nieber, K | 1 |
| Illes, P | 1 |
| Iwai, T | 1 |
| Tanonaka, K | 1 |
| Koshimizu, M | 1 |
| Takeo, S | 1 |
| Mohan, RM | 1 |
| Paterson, DJ | 1 |
| Pelletier, MR | 1 |
| Pahapill, PA | 1 |
| Pennefather, PS | 1 |
| Carlen, PL | 1 |
| Korge, P | 1 |
| Honda, HM | 1 |
| Weiss, JN | 1 |
| MacCormack, TJ | 1 |
| Driedzic, WR | 1 |
| Han, J | 1 |
| Kim, N | 1 |
| Joo, H | 1 |
| Kim, E | 1 |
| Anagnostou, A | 1 |
| Baranowski, R | 1 |
| Pillay, VK | 1 |
| Kurtzman, N | 1 |
| Vercellotti, G | 1 |
| Fried, W | 1 |
| Robertson, BE | 1 |
| Kozlowski, RZ | 1 |
| Nye, PC | 1 |
| Antoine, MH | 1 |
| Herchuelz, A | 1 |
| Lebrun, P | 1 |
| Krnjević, K | 1 |
| Etheridge, JE | 1 |
| Hellman, B | 1 |
| Sehlin, J | 1 |
| Täljedal, IB | 1 |
| Porte, D | 1 |
| Robertson, RP | 1 |
| Milner, RD | 2 |
| Hales, CN | 2 |
3 reviews available for diazoxide and Hypoxia
| Article | Year |
|---|---|
Hypoglycemia and the central nervous system.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Child, Preschool; Diazoxide; Diet Therapy; Epin | 1967 |
Control of insulin secretion by catecholamines, stress, and the sympathetic nervous system.
Topics: Animals; Caffeine; Catecholamines; Cyclic AMP; Diazoxide; Epinephrine; Glucose; Hypothermia; Hypoxia | 1973 |
The mechanism of insulin secretion studied through the effects of electrolytes and inhibitors.
Topics: Animals; Calcium; Diabetes Mellitus; Diazoxide; Enzyme Induction; Epinephrine; Glucagon; Hypoxia; In | 1970 |
34 other studies available for diazoxide and Hypoxia
| Article | Year |
|---|---|
Diazoxide Needs Mitochondrial Connexin43 to Exert Its Cytoprotective Effect in a Cellular Model of CoCl
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Cobalt; Connexin 43; Cytoprotection; Diazoxide; Hypoxi | 2021 |
Diazoxide promotes oligodendrocyte differentiation in neonatal brain in normoxia and chronic sublethal hypoxia.
Topics: Adenomatous Polyposis Coli Protein; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Ba | 2014 |
K(ATP) channels and MPTP are involved in the cardioprotection bestowed by chronic intermittent hypobaric hypoxia in the developing rat.
Topics: Animals; Atmospheric Pressure; Atractyloside; Cardiotonic Agents; Cyclosporine; Decanoic Acids; Diaz | 2015 |
Genome-Wide Expression Profiling of Anoxia/Reoxygenation in Rat Cardiomyocytes Uncovers the Role of MitoKATP in Energy Homeostasis.
Topics: Acyl-CoA Dehydrogenase; Adenosine Triphosphate; Animals; Calcium; Cell Survival; Decanoic Acids; Dia | 2015 |
Bioenergetic and volume regulatory effects of mitoKATP channel modulators protect against hypoxia-reoxygenation-induced mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Animals; Buffers; Cell Respiration; Decanoic Acids; Diazoxide; Energy Metabo | 2016 |
Chronic sustained and intermittent hypoxia reduce function of ATP-sensitive potassium channels in nucleus of the solitary tract.
Topics: Animals; Antihypertensive Agents; Blotting, Western; Carotid Body; Chronic Disease; Diazoxide; Elect | 2008 |
Preconditioning with diazoxide prevents reoxygenation-induced rigor-type hypercontracture.
Topics: Animals; Decanoic Acids; Diazoxide; Hydroxy Acids; Hypoxia; Ischemic Preconditioning, Myocardial; KA | 2010 |
Transient anoxia and oxyradicals induce a region-specific activation of MAPKs in the embryonic heart.
Topics: Animals; Chick Embryo; Diazoxide; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular | 2010 |
[Akt involved in diazoxide preconditioning against rat hippocampal neuronal apoptosis induced by anoxia-reoxygenation injury].
Topics: Animals; Apoptosis; Cells, Cultured; Diazoxide; Hippocampus; Hypoxia; Neurons; Proto-Oncogene Protei | 2010 |
Diazoxide preconditioning alleviates caspase-dependent and caspase-independent apoptosis induced by anoxia-reoxygenation of PC12 cells.
Topics: Animals; Apoptosis; Caspases; Cell Survival; Diazoxide; Glucose; Hypoxia; Mitochondria; Oxygen; PC12 | 2010 |
Mechanisms involved in the desflurane-induced post-conditioning of isolated human right atria from patients with type 2 diabetes.
Topics: Aged; Anesthetics, Inhalation; Blotting, Western; Decanoic Acids; Desflurane; Diabetes Mellitus, Typ | 2011 |
Effects of mitochondrial K(ATP) modulators on cardioprotection induced by chronic high altitude hypoxia in rats.
Topics: Altitude; Analysis of Variance; Animals; Benzopyrans; Chronic Disease; Decanoic Acids; Diazoxide; Hy | 2002 |
Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cell Survival; Decanoic Acids; Diazoxide; Hippocamp | 2003 |
ROS are required for rapid reactivation of Na+/Ca2+ exchanger in hypoxic reoxygenated guinea pig ventricular myocytes.
Topics: Animals; Antioxidants; Cells, Cultured; Chromans; Diazoxide; Free Radical Scavengers; Guinea Pigs; H | 2004 |
mitoKATP channel activation in the postanoxic developing heart protects E-C coupling via NO-, ROS-, and PKC-dependent pathways.
Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Chick Embryo; Chickens; Decanoic Acids; Diaz | 2005 |
Cardioprotective effects of K ATP channel activation during hypoxia in goldfish Carassius auratus.
Topics: Acclimatization; Action Potentials; Analysis of Variance; Animals; Cyclic GMP; Diazoxide; Glyburide; | 2005 |
Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury.
Topics: Animals; Antihypertensive Agents; Blotting, Western; Calcium; Cardiotonic Agents; Cell Line; Cytosol | 2006 |
Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle.
Topics: Adenosine Triphosphate; Animals; Calcium; Cerebral Cortex; Cromakalim; Decanoic Acids; Diazoxide; Gl | 2008 |
Activation of potassium channels contributes to hypoxic injury in proximal tubules.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Diazoxide; DNA Damage; Dose-Response Relation | 1994 |
Hypoxia activates ATP-dependent potassium channels in inspiratory neurones of neonatal mice.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Calcium; Diazoxide; Electric Stimulation; Glyburi | 1998 |
Changes by short-term hypoxia in the membrane properties of pyramidal cells and the levels of purine and pyrimidine nucleotides in slices of rat neocortex; effects of agonists and antagonists of ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Hypoxia; Male; Membrane Potentials; Neocortex; Potassium | 1998 |
Preservation of mitochondrial function by diazoxide during sustained ischaemia in the rat heart.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Creatine Kinase; Diazoxide; Diuretics; Energy | 2000 |
Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation.
Topics: Analysis of Variance; Animals; Cyclic GMP; Diazoxide; Electric Stimulation; Enzyme Inhibitors; Glybu | 2000 |
Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells.
Topics: Animals; Antihypertensive Agents; Dentate Gyrus; Diazoxide; Glyburide; Hypoglycemia; Hypoglycemic Ag | 2000 |
Intrinsic optical signals in respiratory brain stem regions of mice: neurotransmitters, neuromodulators, and metabolic stress.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Adenosine Triphosphate; Animals; Animals, Newborn; | 2001 |
Protection of cardiac mitochondria by diazoxide and protein kinase C: implications for ischemic preconditioning.
Topics: Animals; Cell Membrane Permeability; Decanoic Acids; Diazoxide; Enzyme Activation; Hydroxy Acids; Hy | 2002 |
Mitochondrial ATP-sensitive K+ channels influence force development and anoxic contractility in a flatfish, yellowtail flounder Limanda ferruginea, but not Atlantic cod Gadus morhua heart.
Topics: Aerobiosis; Animals; ATP-Binding Cassette Transporters; Decanoic Acids; Diazoxide; Fishes; Flounder; | 2002 |
Ketamine abolishes ischemic preconditioning through inhibition of K(ATP) channels in rabbit hearts.
Topics: Animals; Cell Separation; Cytoprotection; Diazoxide; Heart; Hypoxia; In Vitro Techniques; Ischemic P | 2002 |
Effect of renin on extrarenal erythropoietin production.
Topics: Angiotensin II; Animals; Blood Pressure; Diazoxide; Erythropoietin; Female; Hypoxia; Mice; Mice, Inb | 1976 |
Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Po | 1992 |
Anoxia and glucose-sensitive 86Rb outflow from rat portal vein.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Glucose; Guanidines; Hypoxia; P | 1992 |
Adenosine triphosphate-sensitive potassium channels in anoxia.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Electrophysiology; Glyburide; Hippocampus; Hypoxia; Neur | 1990 |
Transport of -aminoisobutyric acid in mammalian pancretic -cells.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Butyrates; Cyclic AMP; D | 1971 |
The interaction of various inhibitors and stimuli of insulin release studied with rabbit pancreas in vitro.
Topics: Animals; Barium; Diazoxide; Dibucaine; Dinitrophenols; Epinephrine; Glucose; Heptoses; Hypoxia; In V | 1969 |