diazoxide has been researched along with Hypoxia-Ischemia, Brain in 6 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diazoxide treatment might represent a novel therapeutic target for the treatment of ischemic cerebrovascular diseases." | 1.37 | AIF-mediated mitochondrial pathway is critical for the protective effect of diazoxide against SH-SY5Y cell apoptosis. ( Feng, J; Luo, Y; Song, LC; Wang, ZQ; Zhang, H; Zhao, DY; Zheng, DM, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Zeng, H | 1 |
| Liu, H | 1 |
| Zhang, H | 1 |
| Wang, ZQ | 1 |
| Zhao, DY | 1 |
| Zheng, DM | 1 |
| Feng, J | 1 |
| Song, LC | 1 |
| Luo, Y | 1 |
| Jiang, K | 1 |
| Zhao, Z | 1 |
| Shui, Q | 1 |
| Xia, Z | 1 |
| Jiang, KW | 1 |
| Yu, ZS | 1 |
| Shui, QX | 1 |
| Xia, ZZ | 1 |
| Brockhaus, J | 1 |
| Deitmer, JW | 1 |
| Nakagawa, I | 1 |
| Nakase, H | 1 |
| Aketa, S | 1 |
| Kamada, Y | 1 |
| Yamashita, M | 1 |
| Sakaki, T | 1 |
6 other studies available for diazoxide and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
MiR-21 participates in the neuroprotection of diazoxide against hypoxic-ischemia encephalopathy by targeting PDCD4.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Diazoxide; Humans; Hypoxia-Ischemia, Brain; Infan | 2022 |
AIF-mediated mitochondrial pathway is critical for the protective effect of diazoxide against SH-SY5Y cell apoptosis.
Topics: Apoptosis Inducing Factor; Cell Line, Tumor; Diazoxide; Glucose; Humans; Hypoxia-Ischemia, Brain; Mi | 2011 |
Electro-acupuncture preconditioning abrogates the elevation of c-Fos and c-Jun expression in neonatal hypoxic-ischemic rat brains induced by glibenclamide, an ATP-sensitive potassium channel blocker.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Blotting, Western; Brain; Diazoxide; Disease Mod | 2004 |
Activation of ATP-sensitive potassium channels prevents the cleavage of cytosolic mu-calpain and abrogates the elevation of nuclear c-Fos and c-Jun expressions after hypoxic-ischemia in neonatal rat brain.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Blood Glucose; Blotting, Western; Brain; Calpain; | 2005 |
Developmental downregulation of ATP-sensitive potassium conductance in astrocytes in situ.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cellular Senescence; Cerebellum; Cyclic AMP; Diazoxide; | 2000 |
ATP-dependent potassium channel mediates neuroprotection by chemical preconditioning with 3-nitropropionic acid in gerbil hippocampus.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Convulsants; Diazoxide; Excitatory Postsyna | 2002 |