diazoxide has been researched along with Hypotension in 33 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study sought to determine whether chemical destruction of peripheral catecholaminergic fibers with 6-hydroxydopamine (6OHDA) attenuates vasopressin (VP) and oxytocin (OT) secretion stimulated by hemorrhage, hypotension, and hyperosmolality." | 7.73 | Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats. ( Lone, U; Madden, CJ; Stocker, SD; Sved, AF; Wilson, ME, 2006) |
| "Previous experiments have indicated that arterial hypotension increases plasma oxytocin (OT) levels in rats and that OT infused intravenously causes an increase in plasma renin activity (PRA)." | 7.71 | Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats. ( Huang, W; Sjöquist, M; Skott, O; Stricker, EM; Sved, AF, 2001) |
| "Diazoxide, a potent vasodilator and antidiuretic, was used to examine the relationship between hypotension and thirst in conscious rats with indwelling arterial and venous catheters." | 7.68 | Relationship between thirst and diazoxide-induced hypotension in rats. ( Evered, MD, 1990) |
| "A 30 year-old male patient with accelerated arterial hypertension relatively resistent to diazoxide received a single oral dose of 100 mg of atenolol, following which hypotension of more than 24 hours duration and acute renal failure ensued." | 7.66 | [Prolonged hypotension after the first dose of atenolol (author's transl)]. ( Botey, A; Darnell, A; Montoliu, J; Revert, L, 1981) |
| "Diazoxide, 300 mg as a single bolus injection, is widely used to treat severe hypertension." | 7.66 | Individual titration of diazoxide dosage in the treatment of severe hypertension. ( Kaplan, NM; Ram, CV, 1979) |
| "Diazoxide is a peripheral vasodilator that has been used for intravenous treatment of hypertensive emergencies." | 5.56 | Cerebral Insufficiency Caused by Diazoxide in a Premature Neonate with Congenital Hyperinsulinism. ( Fukunaga, S; Furuta, T; Hirano, R; Ishikawa, Y; Motonaga, T; Ohta, H; Okada, S, 2020) |
| "The present study sought to determine whether chemical destruction of peripheral catecholaminergic fibers with 6-hydroxydopamine (6OHDA) attenuates vasopressin (VP) and oxytocin (OT) secretion stimulated by hemorrhage, hypotension, and hyperosmolality." | 3.73 | Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats. ( Lone, U; Madden, CJ; Stocker, SD; Sved, AF; Wilson, ME, 2006) |
| "Previous experiments have indicated that arterial hypotension increases plasma oxytocin (OT) levels in rats and that OT infused intravenously causes an increase in plasma renin activity (PRA)." | 3.71 | Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats. ( Huang, W; Sjöquist, M; Skott, O; Stricker, EM; Sved, AF, 2001) |
| " The protein, Fos, was detected immunohistochemically and used to highlight neurons that were activated by hypotension (-16+/-5 mmHg) induced by diazoxide (30 mg/kg s." | 3.70 | Neurons in the hypothalamic paraventricular nucleus that project to the rostral ventrolateral medulla are not activated by hypotension. ( Badoer, E, 1998) |
| "Diazoxide, a potent vasodilator and antidiuretic, was used to examine the relationship between hypotension and thirst in conscious rats with indwelling arterial and venous catheters." | 3.68 | Relationship between thirst and diazoxide-induced hypotension in rats. ( Evered, MD, 1990) |
| "A 30 year-old male patient with accelerated arterial hypertension relatively resistent to diazoxide received a single oral dose of 100 mg of atenolol, following which hypotension of more than 24 hours duration and acute renal failure ensued." | 3.66 | [Prolonged hypotension after the first dose of atenolol (author's transl)]. ( Botey, A; Darnell, A; Montoliu, J; Revert, L, 1981) |
| "Diazoxide, 300 mg as a single bolus injection, is widely used to treat severe hypertension." | 3.66 | Individual titration of diazoxide dosage in the treatment of severe hypertension. ( Kaplan, NM; Ram, CV, 1979) |
| "Diazoxide is a peripheral vasodilator that has been used for intravenous treatment of hypertensive emergencies." | 1.56 | Cerebral Insufficiency Caused by Diazoxide in a Premature Neonate with Congenital Hyperinsulinism. ( Fukunaga, S; Furuta, T; Hirano, R; Ishikawa, Y; Motonaga, T; Ohta, H; Okada, S, 2020) |
| "Diazoxide is a potent and safe antipressor agent for parenteral administration in hypertensive emergencies." | 1.25 | Diazoxide for hypertensive crisis. ( Vidt, DG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (66.67) | 18.7374 |
| 1990's | 5 (15.15) | 18.2507 |
| 2000's | 4 (12.12) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Okada, S | 1 |
| Fukunaga, S | 1 |
| Ohta, H | 1 |
| Furuta, T | 1 |
| Hirano, R | 1 |
| Motonaga, T | 1 |
| Ishikawa, Y | 1 |
| Martínez-Ortega, AJ | 1 |
| Mangas-Cruz, MA | 1 |
| Aliaga-Verdugo, A | 1 |
| Acosta-Delgado, D | 1 |
| Stocker, SD | 3 |
| Smith, CA | 1 |
| Kimbrough, CM | 1 |
| Stricker, EM | 3 |
| Sved, AF | 4 |
| BARTORELLI, C | 1 |
| GARGANO, N | 1 |
| LEONETTI, G | 1 |
| ZANCHETTI, A | 1 |
| CARMINATI, GM | 1 |
| ROWE, GG | 1 |
| LEICHT, TR | 1 |
| BOAKE, WC | 1 |
| KYLE, JC | 1 |
| CRUMPTON, CW | 1 |
| STAQUET, M | 1 |
| YABO, R | 1 |
| VIKTORA, J | 1 |
| WOLFF, F | 1 |
| Wilson, ME | 1 |
| Madden, CJ | 1 |
| Lone, U | 1 |
| Barry, DI | 1 |
| Lassen, NA | 1 |
| Montoliu, J | 1 |
| Botey, A | 1 |
| Darnell, A | 1 |
| Revert, L | 1 |
| Chang, HY | 1 |
| Chen, CW | 1 |
| Hsiue, TR | 1 |
| Chen, CR | 1 |
| Badoer, E | 1 |
| Diéguez, G | 1 |
| Fernández, N | 1 |
| Sánchez, MA | 1 |
| Martínez, MA | 1 |
| García-Villalón, AL | 1 |
| Monge, L | 1 |
| Gómez, B | 1 |
| Huang, W | 1 |
| Sjöquist, M | 1 |
| Skott, O | 1 |
| Abdulla, W | 1 |
| Frey, R | 1 |
| Ram, CV | 1 |
| Kaplan, NM | 1 |
| Henrich, WL | 1 |
| Cronin, R | 1 |
| Miller, PD | 1 |
| Anderson, RJ | 1 |
| Mizroch, S | 1 |
| Yurasek, M | 1 |
| Cremonesi, E | 2 |
| Rodrigues, Ide J | 1 |
| Kumar, GK | 1 |
| Dastoor, FC | 1 |
| Robayo, JR | 1 |
| Razzaque, MA | 1 |
| Vidt, DG | 2 |
| Andersson, SE | 1 |
| Evered, MD | 1 |
| Wales, JK | 1 |
| Grant, AM | 1 |
| Wolff, FW | 1 |
| Michael, CA | 1 |
| Tansey, WA | 1 |
| Williams, EG | 1 |
| Landesman, RH | 1 |
| Schwarz, MJ | 1 |
| Sevitt, LH | 1 |
| Peters, DK | 1 |
| Miller, WE | 1 |
| Gifford, RW | 1 |
| Humphrey, DC | 1 |
| Schneider, KW | 1 |
| Landesman, R | 1 |
| de Souza, JA | 1 |
| Coutinho, EM | 1 |
| Wilson, KH | 1 |
| de Sousa, MB | 1 |
1 review available for diazoxide and Hypotension
| Article | Year |
|---|---|
Cerebral blood flow autoregulation in hypertension and effects of antihypertensive drugs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Cerebrovascular Circulation; Diazoxide; | 1984 |
1 trial available for diazoxide and Hypotension
| Article | Year |
|---|---|
Cerebral symptoms and blood pressure during parenteral administration of chlorpromazine, dihydralazine and diazoxide. Danish multicenter study on acute severe hypertension.
Topics: Blood Pressure; Brain Diseases; Brain Ischemia; Chlorpromazine; Clinical Trials as Topic; Diazoxide; | 1983 |
31 other studies available for diazoxide and Hypotension
| Article | Year |
|---|---|
Cerebral Insufficiency Caused by Diazoxide in a Premature Neonate with Congenital Hyperinsulinism.
Topics: Congenital Hyperinsulinism; Diazoxide; Female; Humans; Hypotension; Infant, Newborn; Infant, Prematu | 2020 |
[Hirata's disease: report of a case].
Topics: Aged, 80 and over; Asian People; Autoimmune Diseases; Diazoxide; Drug Substitution; Edema; HLA-D Ant | 2014 |
Elevated dietary salt suppresses renin secretion but not thirst evoked by arterial hypotension in rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Carbachol; Cardiotonic | 2003 |
Hypotensive and renal effects of diazoxide, a sodiumretaining benzothiadiazine compound.
Topics: Antihypertensive Agents; Benzothiadiazines; Diazoxide; Hypertension; Hypotension; Kidney; Kidney Fun | 1963 |
[Pharmacological properties of diazoxide, a non-diuretic benzothiadiazine derivative with hypotensive action].
Topics: Antihypertensive Agents; Benzothiadiazines; Diazoxide; Diuretics; Hypotension | 1963 |
THE SYSTEMIC AND CORONARY HEMODYNAMIC EFFECTS OF DIAZOXIDE.
Topics: Arrhythmias, Cardiac; Benzothiadiazines; Blood Circulation; Blood Pressure; Chlorothiazide; Coronary | 1963 |
AN ADRENERGIC MECHANISM FOR HYPERGLYCEMIA INDUCED BY DIAZOXIDE.
Topics: Adrenal Glands; Adrenalectomy; Adrenergic Agents; Antihypertensive Agents; Cyanides; Diazoxide; Dogs | 1965 |
Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats.
Topics: Animals; Diazoxide; Dopamine beta-Hydroxylase; Hemorrhage; Hypotension; Hypothalamus; Injections, In | 2006 |
[Prolonged hypotension after the first dose of atenolol (author's transl)].
Topics: Acute Kidney Injury; Adult; Atenolol; Diazoxide; Drug Synergism; Humans; Hypertension; Hypotension; | 1981 |
Role of KATP channels on modulating diaphragmatic microvascular flow during hemorrhagic hypotension.
Topics: Adenosine Triphosphate; Animals; Diaphragm; Diazoxide; Glyburide; Hemorrhage; Hypotension; Laser-Dop | 1997 |
Neurons in the hypothalamic paraventricular nucleus that project to the rostral ventrolateral medulla are not activated by hypotension.
Topics: Animals; Axonal Transport; Blood Pressure; Catheterization; Cell Count; Cell Nucleus; Diazoxide; Hyp | 1998 |
Role of nitric oxide in the cerebral circulation during hypotension after hemorrhage, ganglionic blockade and diazoxide in awake goats.
Topics: Animals; Blood Pressure; Cerebrovascular Circulation; Diazoxide; Enzyme Inhibitors; Female; Ganglion | 1999 |
Role of renin-angiotensin system in hypotension-evoked thirst: studies with hydralazine.
Topics: Animals; Diazoxide; Drinking; Drug Combinations; Hydralazine; Hypotension; Isoproterenol; Male; Poly | 2000 |
Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats.
Topics: Animals; Diazoxide; Heart Rate; Hormone Antagonists; Hydralazine; Hypotension; Kinetics; Male; Oxyto | 2001 |
[Hypertension and anesthesia (author's transl)].
Topics: Adrenergic beta-Antagonists; Anesthesia; Antihypertensive Agents; Clonidine; Diazoxide; Dihydralazin | 1977 |
Individual titration of diazoxide dosage in the treatment of severe hypertension.
Topics: Adult; Aged; Blood Pressure; Diazoxide; Drug Administration Schedule; Humans; Hypertension; Hypotens | 1979 |
Hypotensive sequelae of diazoxide and hydralazine therapy.
Topics: Adult; Diazoxide; Drug Synergism; Female; Humans; Hydralazine; Hypotension; Male; Middle Aged; Pregn | 1977 |
Hypotension and bradycardia following diazoxide and hydralazine therapy.
Topics: Bradycardia; Diazoxide; Humans; Hydralazine; Hypertension; Hypotension; Male; Middle Aged | 1977 |
[Interaction of diazoxide and halothane].
Topics: Animals; Diazoxide; Dogs; Drug Interactions; Ephedrine; Halothane; Hypotension | 1978 |
Side effects of diazoxide.
Topics: Acute Disease; Diazoxide; Female; Hemiplegia; Humans; Hypertension; Hypotension; Injections, Intrave | 1976 |
Diazoxide for hypertensive crisis.
Topics: Adolescent; Cardiac Output; Diazoxide; Glomerular Filtration Rate; Half-Life; Heart Rate; Humans; Hy | 1975 |
Glibenclamide and L-NG-nitro-arginine methyl ester modulate the ocular and hypotensive effects of calcitonin gene-related peptide.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Calcitonin Gene-Related Peptide; Diaz | 1992 |
Relationship between thirst and diazoxide-induced hypotension in rats.
Topics: Angiotensin II; Animals; Blood Volume; Captopril; Cardiovascular System; Diazoxide; Drinking; Hypote | 1990 |
Reversal of diazoxide effects by tolbutamide.
Topics: Animals; Blood Glucose; Blood Pressure; Diazoxide; Diuresis; Dogs; Ethacrynic Acid; Hyperglycemia; H | 1967 |
The treatment of malignant hypertension and hypertensive emergencies. A statement by the AMA committee on hypertension.
Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Diazoxide; Drug Evaluation; Emergenci | 1974 |
Intravenous diazoxide in the treatment of severe pre-eclamptic toxaemia and eclampsia.
Topics: Adolescent; Adult; Delivery, Obstetric; Diazepam; Diazoxide; Eclampsia; Female; Fetal Death; Humans; | 1973 |
Diazoxide.
Topics: Diazoxide; Humans; Hypotension | 1973 |
Diazoxide and hypotension.
Topics: Diazoxide; Humans; Hypotension; Hypotension, Orthostatic; Methyldopa | 1971 |
Management of severe hypertension with intravenous injections of diazoxide.
Topics: Adolescent; Adult; Aged; Blood Glucose; Blood Urea Nitrogen; Child; Diazoxide; Female; Humans; Hyper | 1969 |
[Effect of saluretics on hemodynamics].
Topics: Adult; Blood Pressure; Blood Volume; Cardiac Output; Central Venous Pressure; Chlorothiazide; Depres | 1969 |
The inhibitory effect of diazoxide in normal term labor.
Topics: Blood Pressure; Diazoxide; Female; Fetal Heart; Heart Rate; Humans; Hypotension; Labor, Obstetric; M | 1969 |