diazoxide has been researched along with Hypertension, Malignant in 62 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Hypertension, Malignant: A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment." | 7.65 | Use of diazoxide in hypertension with renal failure. ( Pohl, JE; Thurston, H, 1971) |
| "Diazoxide was given orally to nine hypertensive patients with renal failure and its effect on blood pressure and on glucose metabolism was studied." | 5.25 | Oral diazoxide contraindicated in severe hypertension with renal failure. ( Belpaire, FM; De Broe, ME; Mussche, MM; Ringoir, SM; Vermeulen, A, 1975) |
| " diazoxide in a dosage of 5 mg/kg b." | 5.25 | Diazoxide in the management of severe hypertension. ( Kolendorf, K; Moller, BB, 1975) |
| "Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment." | 3.65 | Use of diazoxide in hypertension with renal failure. ( Pohl, JE; Thurston, H, 1971) |
| "Diazoxide was the most effective treatment but was the most difficult and unpleasant to use." | 2.65 | Treatment of refractory hypertension. ( Bing, RF; Heagerty, A; Pohl, JE; Russell, GI; Swales, JD; Thurston, H, 1982) |
| "Resistant hypertension was a frequent phenomenon when ganglion blocking agents and hydrallazine were the only effective hypotensive agents." | 1.26 | The treatment of resistant hypertension. ( Kincaid-Smith, PS, 1976) |
| "Diazoxide was given orally to nine hypertensive patients with renal failure and its effect on blood pressure and on glucose metabolism was studied." | 1.25 | Oral diazoxide contraindicated in severe hypertension with renal failure. ( Belpaire, FM; De Broe, ME; Mussche, MM; Ringoir, SM; Vermeulen, A, 1975) |
| "Diazoxide is a potent and safe antipressor agent for parenteral administration in hypertensive emergencies." | 1.25 | Diazoxide for hypertensive crisis. ( Vidt, DG, 1975) |
| " diazoxide in a dosage of 5 mg/kg b." | 1.25 | Diazoxide in the management of severe hypertension. ( Kolendorf, K; Moller, BB, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 62 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| WOELFER, HJ | 1 |
| SCHNEIDER, KW | 1 |
| HOCHREIN, H | 1 |
| Swales, JD | 3 |
| Bing, RF | 1 |
| Heagerty, A | 1 |
| Pohl, JE | 5 |
| Russell, GI | 1 |
| Thurston, H | 5 |
| Abe, I | 1 |
| Kawasaki, T | 1 |
| Kawazoe, N | 1 |
| Omae, T | 1 |
| Vaziri, ND | 1 |
| Ram, CV | 3 |
| Grossman, SH | 1 |
| Gunnells, JC | 1 |
| Leroux-Robert, C | 1 |
| Charmes, JP | 1 |
| Benevent, D | 1 |
| Rince, M | 1 |
| Grim, CE | 3 |
| Kincaid-Smith, PS | 1 |
| Weidmann, P | 1 |
| Keusch, G | 1 |
| Morris, AI | 1 |
| Montuschi, E | 1 |
| Pryor, JS | 1 |
| Davies, PD | 1 |
| Hamilton, DV | 1 |
| Thien, T | 1 |
| Huysmans, FT | 2 |
| Koene, RA | 2 |
| Waugh, WH | 1 |
| Thien, TA | 1 |
| Gerlag, PG | 1 |
| Wijdeveld, PG | 1 |
| Anttila, P | 1 |
| Pasternack, A | 1 |
| Woods, JW | 1 |
| Mussche, MM | 1 |
| De Broe, ME | 1 |
| Belpaire, FM | 1 |
| Vermeulen, A | 1 |
| Ringoir, SM | 1 |
| Haas, Th | 1 |
| Denkl, P | 1 |
| Fleischmann, LE | 1 |
| Lifschitz, MD | 1 |
| Cody, T | 1 |
| Mroczek, WJ | 2 |
| Brodwall, EK | 1 |
| Flatmark, A | 1 |
| Farn, KT | 1 |
| Vidt, DG | 1 |
| Curry, CL | 1 |
| Moller, BB | 1 |
| Kolendorf, K | 1 |
| Blumberg, A | 1 |
| Studer, U | 1 |
| Briner, J | 1 |
| Ferguson, RK | 1 |
| Vlasses, PH | 1 |
| Meese, RB | 1 |
| Burris, JF | 1 |
| De Broe, M | 1 |
| Mussche, M | 1 |
| Bosteels, V | 1 |
| Perret, C | 1 |
| Girardet, P | 1 |
| Philipp, T | 1 |
| Nast, HP | 1 |
| Fang, P | 1 |
| MacDonald, I | 1 |
| Laver, M | 1 |
| Hua, A | 1 |
| Kincaid-Smith, P | 3 |
| Finnerty, FA | 4 |
| Acchiardo, SR | 1 |
| Black, WD | 1 |
| Britt, L | 1 |
| McKeown, JW | 1 |
| Johnson, JG | 1 |
| Hatch, F | 1 |
| Muldowney, FP | 1 |
| Fillastre, JP | 1 |
| Malandain, M | 1 |
| Gray, H | 1 |
| Dubois, D | 1 |
| Ahearn, DJ | 1 |
| Moser, M | 1 |
| Nellen, M | 1 |
| Naess, K | 1 |
| Barjon, P | 1 |
| Fourcade, J | 1 |
| Monnier, L | 1 |
| Mimran, A | 1 |
| Taib, J | 1 |
| Sevitt, LH | 1 |
| Evans, DJ | 1 |
| Wrong, OM | 1 |
| Mathew, TH | 2 |
| Kakaviatos, N | 1 |
| Davidov, M | 1 |
| Saker, BM | 1 |
| Eremin, J | 1 |
11 reviews available for diazoxide and Hypertension, Malignant
| Article | Year |
|---|---|
Treating severe hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Diazoxide; Diuretics; Drug Resistance; Drug Th | 1984 |
Malignant or accelerated hypertension.
Topics: Blood Coagulation Disorders; Brain Diseases; Diazoxide; Glomerulosclerosis, Focal Segmental; Humans; | 1984 |
Hypertensive crisis.
Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia | 1984 |
Recognition and treatment of hypertensive emergencies.
Topics: Anticoagulants; Brain Diseases; Cerebrovascular Disorders; Coronary Disease; Diagnosis, Differential | 1981 |
Hypertensive emergencies: recognition and management.
Topics: Acute Disease; Aortic Aneurysm; Aortic Dissection; Brain Diseases; Cerebral Hemorrhage; Coronary Dis | 1982 |
[Treatment of therapy-resistant hypertension].
Topics: Adrenergic beta-Antagonists; Diazoxide; Diuretics; Drug Resistance; Drug Therapy, Combination; Human | 1977 |
Hypertensive emergencies and urgencies.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; | 1986 |
Hypertensive cardiovascular emergencies.
Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia | 1985 |
[Treatment of the hypertensive crisis].
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Antihypertensive Agents; Blood Pressure; Diaz | 1973 |
Malignant hypertension: kidneys too good to be extirpated.
Topics: Animals; Blood Pressure; Diazoxide; Furosemide; Glomerulonephritis; Humans; Hypertension, Malignant; | 1974 |
Treatment of "hypertensive encephalopathy" (accelerated hypertension). II.
Topics: Antihypertensive Agents; Diazoxide; Glomerulonephritis; Guanethidine; Humans; Hydralazine; Hypertens | 1969 |
2 trials available for diazoxide and Hypertension, Malignant
| Article | Year |
|---|---|
Treatment of refractory hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Captopril; Clinical Trials as Topic; Diazoxide | 1982 |
Diazoxide in the treatment of hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Child, Preschool; Clinical Tria | 1970 |
49 other studies available for diazoxide and Hypertension, Malignant
| Article | Year |
|---|---|
[CLINICAL AND HEMODYNAMIC STUDIES ON A NEW ANTIHYPERTENSIVE SUBSTANCE FROM THE THIAZIDE GROUP WITHOUT DIURETIC EFFECT].
Topics: Antihypertensive Agents; Benzothiadiazines; Biomedical Research; Blood Circulation; Blood Pressure; | 1963 |
Acute electrocardiographic effects of captopril in the initial treatment of malignant or severe hypertension.
Topics: Adult; Blood Pressure; Captopril; Diazoxide; Drug Evaluation; Electrocardiography; Female; Heart Rat | 1983 |
[Treatment of malignant arterial hypertension].
Topics: Acute Kidney Injury; Clonidine; Diazoxide; Dihydralazine; Diuretics; Humans; Hypertension, Malignant | 1980 |
Management of malignant hypertension.
Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Clonidine; Diazoxide; Diuretics; Drug | 1980 |
Emergency treatment of severe or malignant hypertension.
Topics: Aged; Antihypertensive Agents; Diazoxide; Emergencies; Furosemide; Humans; Hypertension, Malignant; | 1980 |
The treatment of resistant hypertension.
Topics: Adrenergic beta-Antagonists; Chlorothiazide; Diazoxide; Drug Resistance; Drug Therapy, Combination; | 1976 |
Letter: Growth of head hair during treatment with diazoxide.
Topics: Adult; Diazoxide; Hair; Humans; Hypertension, Malignant; Male | 1975 |
Blindness and malignant hypertension.
Topics: Adolescent; Blindness; Diazoxide; Humans; Hypertension, Malignant; Male | 1979 |
Acute blood-pressure reduction in malignant hypertension.
Topics: Blood Pressure; Diazoxide; Humans; Hypertension, Malignant | 1979 |
Efficacy of slow injection of diazoxide in accelerated hypertension.
Topics: Adult; Diazoxide; Humans; Hypertension, Malignant; Injections, Intravenous; Middle Aged | 1977 |
Diazoxide infusion in severe hypertension and hypertensive crisis.
Topics: Adult; Blood Pressure; Diazoxide; Female; Humans; Hypertension; Hypertension, Malignant; Infusions, | 1979 |
[Use of diazoxide in the treatment of severe hypertension].
Topics: Adult; Diazoxide; Humans; Hyperglycemia; Hypernatremia; Hypertension, Malignant; Male; Middle Aged | 1977 |
Malignant hypertension: clinical recognition and management.
Topics: Adult; Diazoxide; Female; Humans; Hydralazine; Hypertension; Hypertension, Malignant; Kidney; Male; | 1978 |
Oral diazoxide contraindicated in severe hypertension with renal failure.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Blood Glucose; Diabetic Ketoacidosis; Diazoxide; F | 1975 |
[Therapy of hypertensive crises].
Topics: Acute Disease; Adrenal Gland Neoplasms; Antihypertensive Agents; Clonidine; Diazoxide; Dihydralazine | 1977 |
Management of hypertensive crisis in children.
Topics: Acute Disease; Adolescent; Cerebrovascular Disorders; Child; Child, Preschool; Diazoxide; Humans; Hy | 1977 |
Spontaneous remission of accelerated (malignant) hypertension in renal infarction.
Topics: Adult; Diazoxide; Furosemide; Humans; Hypertension, Malignant; Infarction; Kidney; Male; Methyldopa; | 1977 |
Malignant hypertension.
Topics: Diazoxide; Diuretics; Humans; Hydralazine; Hypertension, Malignant; Kidney; Nephrectomy; Nitroprussi | 1977 |
[Treatment of malignant hypertension].
Topics: Adolescent; Adult; Diazoxide; Humans; Hydralazine; Hypertension, Malignant; Male; Reserpine | 1976 |
Diazoxide in treatment of hypertension.
Topics: Diazoxide; Female; Humans; Hypertension, Malignant | 1976 |
Diazoxide for hypertensive crisis.
Topics: Adolescent; Cardiac Output; Diazoxide; Glomerular Filtration Rate; Half-Life; Heart Rate; Humans; Hy | 1975 |
Current treatment of malignant hypertension.
Topics: Acute Disease; Administration, Oral; Antihypertensive Agents; Blood Pressure; Diazoxide; Diuretics; | 1975 |
Diazoxide in the management of severe hypertension.
Topics: Adult; Aged; Creatinine; Diazoxide; Female; Humans; Hypertension; Hypertension, Malignant; Hypertens | 1975 |
[Hemolytic-uremic syndrome in a young woman following the use of ovulation inhibitors].
Topics: Adult; Blindness; Clonidine; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Diazoxide; Female | 1975 |
Hypertensive emergencies.
Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Diazoxide; Emergencies; Humans; Hydralazine; Hyp | 1985 |
Bilateral nephrectomy for malignant hypertension.
Topics: Diazoxide; Humans; Hypertension, Malignant; Nephrectomy | 1972 |
Oral diazoxide for malignant hypertension.
Topics: Acute Kidney Injury; Administration, Oral; Adult; Diabetic Ketoacidosis; Diazoxide; Female; Humans; | 1972 |
[Hypertensive emergencies].
Topics: Brain Edema; Clonidine; Diazoxide; Digitalis Glycosides; Diuretics; Drug Combinations; Emergencies; | 1974 |
Treatment of hypertensive crisis.
Topics: Adrenergic alpha-Antagonists; Diazoxide; Ethacrynic Acid; Ferricyanides; Furosemide; Humans; Hydrala | 1970 |
The treatment of malignant hypertension and hypertensive emergencies. A statement by the AMA committee on hypertension.
Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Diazoxide; Drug Evaluation; Emergenci | 1974 |
Editoral: Diazoxide in malignant hypertension.
Topics: Diazoxide; Drug Therapy, Combination; Humans; Hypertension, Malignant; Minoxidil; Propranolol | 1974 |
Oral diazoxide in uncontrolled malignant hypertension.
Topics: Administration, Oral; Creatinine; Diazoxide; Edema; Furosemide; Humans; Hypertension, Malignant; Hyp | 1974 |
Renal effects of diazoxide and frusemide and interrelationships.
Topics: Creatinine; Diazoxide; Diuretics; Ethacrynic Acid; Female; Follow-Up Studies; Furans; Furosemide; Gl | 1974 |
Aggressive drug therapy in accelerated hypertension.
Topics: Antihypertensive Agents; Aortic Aneurysm; Brain Diseases; Cerebrovascular Disorders; Diazoxide; Ferr | 1974 |
Experience with hemodialysis and renal transplantation in patients with malignant hypertension.
Topics: Acute Kidney Injury; Adult; Brain Diseases; Diazoxide; Diet Therapy; Female; Follow-Up Studies; Furo | 1974 |
Management of severe hypertension.
Topics: Chlorthalidone; Coma; Debrisoquin; Diazoxide; Guanethidine; Humans; Hypertension, Malignant; Methyld | 1972 |
[Treatment of malignant nephroangiosclerosis with diazoxide].
Topics: Diazoxide; Glomerular Filtration Rate; Humans; Hydralazine; Hypertension, Malignant; Injections, Int | 1972 |
Diazoxide (hyperstat).
Topics: Blood Pressure; Diazoxide; Ethacrynic Acid; Female; Furosemide; Humans; Hypertension; Hypertension, | 1973 |
Treatment of malignant hypertension with sodium nitroprusside.
Topics: Administration, Oral; Adult; Aged; Blood Pressure; Chemical Phenomena; Chemistry; Diazoxide; Drug Re | 1974 |
Editorial: Malignant hypertension.
Topics: Blood Pressure; Cardiac Output; Diazoxide; Ferricyanides; Furosemide; Humans; Hydralazine; Hypertens | 1974 |
Hypertensive encephalopathy.
Topics: Anxiety; Brain Diseases; Brain Edema; Coma; Diazoxide; Female; Furosemide; Glomerulonephritis; Heada | 1972 |
[Diazoxide and malignant hypertension].
Topics: Diazoxide; Humans; Hypertension, Malignant | 1972 |
[Hyperglycemic coma without ketoacidosis in 2 hypertensive patients treated with intravenous diazoxide].
Topics: Aged; Coma; Diazoxide; Female; Glucose Tolerance Test; Humans; Hyperglycemia; Hypertension; Hyperten | 1972 |
Acute oliguric renal failure due to accelerated (malignant) hypertension.
Topics: Acute Kidney Injury; Adolescent; Adult; Antihypertensive Agents; Anuria; Blood Urea Nitrogen; Diazox | 1971 |
Use of diazoxide in hypertension with renal failure.
Topics: Adolescent; Adult; Blood Glucose; Creatine; Diazoxide; Dietary Proteins; Female; Humans; Hyperglycem | 1971 |
The use of diazoxide in hypertensive crises with particular reference to the control of hypertension in severe renal failure.
Topics: Acute Kidney Injury; Antihypertensive Agents; Blood Pressure; Depression, Chemical; Diazoxide; Femal | 1971 |
The long term effect of repeated acute reductions of arterial pressure with diazoxide in patients with severe hypertension.
Topics: Acidosis; Blood Glucose; Diazoxide; Heart; Heart Failure; Humans; Hyperaldosteronism; Hypertension; | 1968 |
The use of diazoxide in hypertension with renal damage.
Topics: Diazoxide; Humans; Hypertension, Malignant; Kidney Diseases | 1971 |
Diazoxide in the treatment of the acute hypertensive emergency.
Topics: Adolescent; Adult; Blood Pressure; Diazoxide; Emergencies; Female; Glomerulonephritis; Humans; Hyper | 1968 |