Page last updated: 2024-10-25

diazoxide and Hyperphagia

diazoxide has been researched along with Hyperphagia in 3 studies

Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.

Hyperphagia: Ingestion of a greater than optimal quantity of food.

Research Excerpts

ExcerptRelevanceReference
"In DESTINY PWS, a 13-week, randomized, double-blind, placebo-controlled, phase 3 trial, 127 participants with PWS aged 4 years and older with hyperphagia were randomly assigned 2:1 to diazoxide choline extended-release tablet (DCCR) or placebo."9.69Diazoxide Choline Extended-Release Tablet in People With Prader-Willi Syndrome: A Double-Blind, Placebo-Controlled Trial. ( Abuzzahab, J; Angulo, M; Barrett, T; Bhatnagar, A; Bird, LM; Bridges, N; Butler, MG; Cowen, NM; Felner, EI; Gevers, E; Lah, M; Littlejohn, E; Mathew, V; Miller, JL; Obrynba, KS; Salehi, P; Shoemaker, AH; Stevenson, D; Yanovski, JA, 2023)
" The most common adverse events were peripheral edema and transient increases in glucose."6.90A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome. ( Cowen, NM; Gold, JA; Kimonis, V; Surampalli, A; Wencel, M, 2019)
"In DESTINY PWS, a 13-week, randomized, double-blind, placebo-controlled, phase 3 trial, 127 participants with PWS aged 4 years and older with hyperphagia were randomly assigned 2:1 to diazoxide choline extended-release tablet (DCCR) or placebo."5.69Diazoxide Choline Extended-Release Tablet in People With Prader-Willi Syndrome: A Double-Blind, Placebo-Controlled Trial. ( Abuzzahab, J; Angulo, M; Barrett, T; Bhatnagar, A; Bird, LM; Bridges, N; Butler, MG; Cowen, NM; Felner, EI; Gevers, E; Lah, M; Littlejohn, E; Mathew, V; Miller, JL; Obrynba, KS; Salehi, P; Shoemaker, AH; Stevenson, D; Yanovski, JA, 2023)
" The most common adverse events were peripheral edema and transient increases in glucose."2.90A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome. ( Cowen, NM; Gold, JA; Kimonis, V; Surampalli, A; Wencel, M, 2019)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Miller, JL1
Gevers, E1
Bridges, N1
Yanovski, JA1
Salehi, P1
Obrynba, KS1
Felner, EI1
Bird, LM1
Shoemaker, AH1
Angulo, M1
Butler, MG1
Stevenson, D1
Abuzzahab, J1
Barrett, T1
Lah, M1
Littlejohn, E1
Mathew, V1
Cowen, NM2
Bhatnagar, A1
Kimonis, V1
Surampalli, A1
Wencel, M1
Gold, JA1
Alemzadeh, R1
Holshouser, S1

Trials

2 trials available for diazoxide and Hyperphagia

ArticleYear
Diazoxide Choline Extended-Release Tablet in People With Prader-Willi Syndrome: A Double-Blind, Placebo-Controlled Trial.
    The Journal of clinical endocrinology and metabolism, 2023, Jun-16, Volume: 108, Issue:7

    Topics: COVID-19; Diazoxide; Humans; Hyperphagia; Obesity; Prader-Willi Syndrome

2023
A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome.
    PloS one, 2019, Volume: 14, Issue:9

    Topics: Adolescent; Basal Metabolism; Body Composition; Child; Delayed-Action Preparations; Diazoxide; Doubl

2019

Other Studies

1 other study available for diazoxide and Hyperphagia

ArticleYear
Effect of diazoxide on brain capillary insulin receptor binding and food intake in hyperphagic obese Zucker rats.
    Endocrinology, 1999, Volume: 140, Issue:7

    Topics: Animals; Blood Glucose; Body Weight; Brain; Capillaries; Diazoxide; Eating; Fasting; Female; Hyperph

1999