diazoxide has been researched along with Hyperglycemia, Postprandial in 108 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Hyperglycemia, Postprandial: Abnormally high BLOOD GLUCOSE level after a meal.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men." | 9.27 | High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018) |
| "The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, and if so, whether the effects could be mediated by mitochondrial ATP-sensitive potassium (m-KATP) channels." | 7.78 | High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels. ( Cho, S; Higashijima, U; Ichinomiya, T; Maekawa, T; Matsumoto, S; Sumikawa, K, 2012) |
| "The efficacy and side effects of two potent vasodilatators, namely diazoxide and minoxidil given orally, were compared in 11 patients who had hypertension refractory to conventional drug treatment." | 7.66 | [Comparison of oral diazoxide and minoxidil in refractory hypertension]. ( Glück, Z; Grimm, M; Keusch, G; Meier, A; Minder, I; Reubi, FC; Weidmann, P, 1980) |
| "Four patients with hypertensive disorders of pregnancy were treated with intravenous diazoxide." | 7.66 | Diazoxide for the acute control of severe hypertension complicating pregnancy: a pilot study. ( Cabal, L; Freeman, RK; Neuman, J; Rabello, Y; Weiss, B, 1979) |
| "The effect of glucagon suppression by somatostatin upon endogenous hyperglycemia was studied in three forms of experimental insulin deficiency in dogs: alloxan diabetes, total pancreatectomy, and diazoxide administration." | 7.65 | The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus. ( Dobbs, RE; Sakurai, H; Unger, RH, 1975) |
| "In two studies for toxicity, cataracts occurred in beagle dogs given diazoxide daily in high doses." | 7.65 | Cataracts in beagle dogs given diazoxide. ( Field, WE; Schiavo, DM; Vymetal, FJ, 1975) |
| "Treatment with oral diazoxide for periods of 4 to 10 weeks in hospital allowed adequate control of hypertension with continuation of fetal growth in four patients with severe toxaemia." | 7.65 | Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy. ( Davis, D; Morgan, MY; Pohl, JE; Thurston, H, 1972) |
| "Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment." | 7.65 | Use of diazoxide in hypertension with renal failure. ( Pohl, JE; Thurston, H, 1971) |
| "Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men." | 5.27 | High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018) |
| "The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, and if so, whether the effects could be mediated by mitochondrial ATP-sensitive potassium (m-KATP) channels." | 3.78 | High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels. ( Cho, S; Higashijima, U; Ichinomiya, T; Maekawa, T; Matsumoto, S; Sumikawa, K, 2012) |
| "To induce acute hyperglycemia, diazoxide, a selective, ATP-sensitive K(+) channel opener was used." | 3.77 | Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassembly. ( Abrahani, A; Kim, MS; Puthanveetil, P; Rodrigues, B; Wang, F; Wang, Y, 2011) |
| " Ovariectomized, steroid-replaced rats were fitted with indwelling jugular catheters and infused for 48 h with saline, glucose (hyperglycemia-hyperinsulinemia), insulin and glucose (hyperinsulinemia), diazoxide (control), or glucose and diazoxide (hyperglycemia)." | 3.74 | Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats. ( Acosta-Martínez, M; Levine, JE, 2007) |
| "Mild hyperglycemia was induced in normal rats by oral administration of both diazoxide and D-glucose." | 3.68 | Attenuated anomeric difference of glucose-induced insulin release in the perfused pancreas of diazoxide-treated rats. ( Leclercq-Meyer, V; Malaisse, WJ; Marchand, J, 1991) |
| "The efficacy and side effects of two potent vasodilatators, namely diazoxide and minoxidil given orally, were compared in 11 patients who had hypertension refractory to conventional drug treatment." | 3.66 | [Comparison of oral diazoxide and minoxidil in refractory hypertension]. ( Glück, Z; Grimm, M; Keusch, G; Meier, A; Minder, I; Reubi, FC; Weidmann, P, 1980) |
| "Four patients with hypertensive disorders of pregnancy were treated with intravenous diazoxide." | 3.66 | Diazoxide for the acute control of severe hypertension complicating pregnancy: a pilot study. ( Cabal, L; Freeman, RK; Neuman, J; Rabello, Y; Weiss, B, 1979) |
| "The effect of glucagon suppression by somatostatin upon endogenous hyperglycemia was studied in three forms of experimental insulin deficiency in dogs: alloxan diabetes, total pancreatectomy, and diazoxide administration." | 3.65 | The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus. ( Dobbs, RE; Sakurai, H; Unger, RH, 1975) |
| "In two studies for toxicity, cataracts occurred in beagle dogs given diazoxide daily in high doses." | 3.65 | Cataracts in beagle dogs given diazoxide. ( Field, WE; Schiavo, DM; Vymetal, FJ, 1975) |
| "Suppression of pancreatic glucagon secretion by hyperglycemia is a characteristic of normal alpha cell function." | 3.65 | The effect of experimental insulin deficiency on glucagon secretion. ( Faloona, GR; Müller, WA; Unger, RH, 1971) |
| "Treatment with oral diazoxide for periods of 4 to 10 weeks in hospital allowed adequate control of hypertension with continuation of fetal growth in four patients with severe toxaemia." | 3.65 | Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy. ( Davis, D; Morgan, MY; Pohl, JE; Thurston, H, 1972) |
| "Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment." | 3.65 | Use of diazoxide in hypertension with renal failure. ( Pohl, JE; Thurston, H, 1971) |
| "Glucose infusion (Hyperglycemia and hyperinsulinemia) significantly increased BDNF mRNA expression in the posterior ventromedial nucleus of the hypothalamus (pVMH) and in the dorsomedial nucleus of the hypothalamus (DMH)." | 1.42 | Prolonged hyperglycemia & hyperinsulinemia increases BDNF mRNA expression in the posterior ventromedial hypothalamus and the dorsomedial hypothalamus of fed female rats. ( Acosta-Martínez, M; Beymer, M; Negrón, AL; Warren, KA; Yu, G, 2015) |
| "Diazoxide (DZ) was used to decrease serum insulin and generate hyperglycemia." | 1.35 | Endothelial heparanase secretion after acute hypoinsulinemia is regulated by glucose and fatty acid. ( Abrahani, A; Deppe, S; Ghosh, S; Kewalramani, G; Kim, MS; Puthanveetil, P; Rodrigues, B; Wang, F, 2009) |
| "Hyperglycemia is an important predictor of cardiovascular mortality in patients with diabetes." | 1.31 | Diabetes and hyperglycemia impair activation of mitochondrial K(ATP) channels. ( Ghassemi, T; Gross, ER; Kersten, JR; Montgomery, MW; Pagel, PS; Toller, WG; Warltier, DC, 2001) |
| "Psammomys obesus is a model of type 2 diabetes that displays resistance to insulin and deranged beta-cell response to glucose." | 1.31 | Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes. ( Cerasi, E; Efendic, S; Kaiser, N; Khan, A; Nesher, R; Warwar, N, 2001) |
| "Cause of renal disease are chronic renal failure in three, acute renal failure in three, hemolytic uremic syndrome in two, acute post streptococcal glomerulonephritis in one, and renal arterial stenosis in a further patient." | 1.26 | [Hypertensive emergencies in children with renal hypertension (author's transl)]. ( Bachmann, HJ; Olbing, H; Pistor, K, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 88 (81.48) | 18.7374 |
| 1990's | 3 (2.78) | 18.2507 |
| 2000's | 6 (5.56) | 29.6817 |
| 2010's | 10 (9.26) | 24.3611 |
| 2020's | 1 (0.93) | 2.80 |
| Authors | Studies |
|---|---|
| Vargas-Vargas, MA | 1 |
| Saavedra-Molina, A | 1 |
| Gómez-Barroso, M | 1 |
| Peña-Montes, D | 1 |
| Cortés-Rojo, C | 1 |
| Rodríguez-Orozco, AR | 1 |
| Rocío, MP | 1 |
| Loves, S | 1 |
| van Groningen, L | 1 |
| Filius, M | 1 |
| Mekking, M | 1 |
| Brandon, T | 1 |
| Tack, CJ | 1 |
| Hermus, A | 1 |
| de Boer, H | 1 |
| Vezzosi, D | 1 |
| Guillaume, E | 1 |
| Bennet, A | 1 |
| Mouly, C | 1 |
| Hanaire, H | 1 |
| Caron, P | 1 |
| de Campos Lima, T | 1 |
| Santos, DO | 1 |
| Lemes, JBP | 1 |
| Chiovato, LM | 1 |
| Lotufo, CMDC | 1 |
| Zhang, D | 2 |
| Wan, A | 2 |
| Chiu, AP | 1 |
| Wang, Y | 3 |
| Wang, F | 4 |
| Neumaier, K | 1 |
| Lal, N | 1 |
| Bround, MJ | 1 |
| Johnson, JD | 1 |
| Vlodavsky, I | 1 |
| Rodrigues, B | 4 |
| Negrón, AL | 1 |
| Beymer, M | 1 |
| Yu, G | 1 |
| Warren, KA | 1 |
| Acosta-Martínez, M | 2 |
| Kim, MS | 2 |
| Puthanveetil, P | 3 |
| Kewalramani, G | 1 |
| Deppe, S | 1 |
| Ghosh, S | 1 |
| Abrahani, A | 3 |
| Luo, P | 1 |
| Chang, HH | 1 |
| Zhou, Y | 1 |
| Zhang, S | 1 |
| Hwang, SH | 1 |
| Morisseau, C | 1 |
| Wang, CY | 1 |
| Inscho, EW | 1 |
| Hammock, BD | 1 |
| Wang, MH | 1 |
| Ichinomiya, T | 1 |
| Cho, S | 1 |
| Higashijima, U | 1 |
| Matsumoto, S | 1 |
| Maekawa, T | 1 |
| Sumikawa, K | 1 |
| Lehner, Z | 1 |
| Stadlbauer, K | 1 |
| Adorjan, I | 1 |
| Rustenbeck, I | 1 |
| Belz, M | 1 |
| Fenzl, A | 1 |
| de Cillia, VA | 1 |
| Gruber, D | 1 |
| Bauer, L | 1 |
| Frobel, K | 1 |
| Brunmair, B | 1 |
| Luger, A | 1 |
| Fürnsinn, C | 1 |
| OKUN, R | 2 |
| RUSSELL, RP | 1 |
| WILSON, WR | 2 |
| WOLFF, F | 8 |
| GELFAND, MD | 1 |
| STAQUET, M | 2 |
| YABO, R | 2 |
| VIKTORA, J | 6 |
| Yamazaki, H | 1 |
| Philbrick, W | 1 |
| Zawalich, KC | 1 |
| Zawalich, WS | 1 |
| Hussain, K | 1 |
| Bryan, J | 1 |
| Christesen, HT | 1 |
| Brusgaard, K | 1 |
| Aguilar-Bryan, L | 1 |
| Levine, JE | 1 |
| Gulbenkian, A | 3 |
| Grasso, AY | 1 |
| Tabachnick, II | 3 |
| Jansen, GR | 1 |
| Hutchison, CF | 1 |
| Zanetti, ME | 1 |
| Johansson, SR | 1 |
| Andersson, RG | 1 |
| Andreoli, SP | 1 |
| Bergstein, JM | 1 |
| Smith, MJ | 1 |
| Aynsley-Green, A | 1 |
| Redman, CW | 1 |
| Milsap, RL | 1 |
| Auld, PA | 1 |
| Meier, A | 1 |
| Weidmann, P | 1 |
| Glück, Z | 1 |
| Keusch, G | 1 |
| Grimm, M | 1 |
| Minder, I | 1 |
| Reubi, FC | 1 |
| Kersten, JR | 1 |
| Montgomery, MW | 1 |
| Ghassemi, T | 1 |
| Gross, ER | 1 |
| Toller, WG | 1 |
| Pagel, PS | 1 |
| Warltier, DC | 1 |
| Nesher, R | 1 |
| Warwar, N | 1 |
| Khan, A | 1 |
| Efendic, S | 1 |
| Cerasi, E | 1 |
| Kaiser, N | 1 |
| Davis, B | 1 |
| Lazarus, NR | 1 |
| Schnatz, JD | 1 |
| Siegel, JH | 1 |
| Neuman, J | 1 |
| Weiss, B | 1 |
| Rabello, Y | 1 |
| Cabal, L | 1 |
| Freeman, RK | 1 |
| Anttila, P | 1 |
| Pasternack, A | 1 |
| Henningsen, L | 1 |
| Johansen, K | 1 |
| Bachmann, HJ | 1 |
| Olbing, H | 1 |
| Pistor, K | 1 |
| Koch-Weser, J | 1 |
| Altszuler, N | 1 |
| Moraru, E | 1 |
| Hampshire, J | 1 |
| Sakurai, H | 1 |
| Dobbs, RE | 1 |
| Unger, RH | 2 |
| Schiavo, DM | 1 |
| Field, WE | 1 |
| Vymetal, FJ | 1 |
| Sako, Y | 2 |
| Eizirik, D | 1 |
| Grill, V | 1 |
| Leclercq-Meyer, V | 1 |
| Marchand, J | 1 |
| Malaisse, WJ | 2 |
| Grill, VE | 1 |
| Arkhammar, P | 1 |
| Nilsson, T | 1 |
| Rorsman, P | 1 |
| Berggren, PO | 1 |
| Tchobroutsky, G | 1 |
| Slama, G | 1 |
| Chast, F | 1 |
| Bergsten, P | 1 |
| Gylfe, E | 1 |
| Wesslén, N | 1 |
| Hellman, B | 8 |
| Gomis, R | 1 |
| Plaza, C | 1 |
| Harrison, BD | 1 |
| Rutter, TW | 1 |
| Taylor, RT | 1 |
| Wales, JK | 2 |
| Grant, AM | 2 |
| Wolff, FW | 3 |
| Grant, A | 2 |
| Wales, J | 2 |
| Yoshinaga, T | 1 |
| Meng, K | 1 |
| Kroneberg, G | 1 |
| Spergel, G | 1 |
| Bleicher, SJ | 2 |
| Schultz, G | 3 |
| Senft, G | 5 |
| Losert, W | 5 |
| Sitt, R | 4 |
| Kaess, H | 3 |
| Moore, PF | 1 |
| Fajans, SS | 1 |
| Floyd, JC | 1 |
| Thiffault, CA | 1 |
| Knopf, RF | 1 |
| Harrison, TS | 1 |
| Conn, JW | 1 |
| Chowdhury, F | 1 |
| Podolsky, S | 1 |
| Fleishman, P | 1 |
| Goldner, MG | 1 |
| Graber, AL | 1 |
| Porte, D | 1 |
| Williams, RH | 1 |
| Dulin, WE | 1 |
| Wyse, BM | 1 |
| Sehlin, J | 5 |
| Täljedal, IB | 4 |
| Barjon, P | 2 |
| Fourcade, J | 2 |
| Monnier, L | 2 |
| Mimran, A | 2 |
| Taib, J | 2 |
| Finnerty, FA | 1 |
| Marks, V | 1 |
| Michael, CA | 1 |
| Lernmark, A | 1 |
| Foy, JM | 1 |
| Furman, BL | 1 |
| Castro, A | 1 |
| Grettie, DP | 1 |
| Black, J | 1 |
| Loubatières, A | 2 |
| Mariani, MM | 2 |
| Alric, R | 2 |
| Hirsch, E | 1 |
| Idahl, LA | 2 |
| Danielsson, A | 2 |
| Frerichs, H | 1 |
| Gerber, R | 1 |
| Creutzfeldt, W | 1 |
| Taylor, KW | 1 |
| Müller, WA | 1 |
| Faloona, GR | 1 |
| Updike, SJ | 1 |
| Harrington, AR | 1 |
| Basabe, JC | 1 |
| Lopez, NL | 1 |
| Krees, SV | 1 |
| Täljedal, I | 1 |
| Pohl, JE | 2 |
| Thurston, H | 2 |
| Davis, D | 1 |
| Morgan, MY | 1 |
| Johnson, BF | 1 |
| Kapur, M | 1 |
| Knapp, MS | 1 |
| Cove-Smith, R | 1 |
| Hall, G | 1 |
| McIllmurray, M | 1 |
| McLaine, PN | 1 |
| Drummond, KN | 1 |
| Danforth, E | 2 |
| Mathew, TH | 1 |
| Kincaid-Smith, P | 1 |
| Green, OC | 1 |
| Berger, S | 1 |
| Townley, RG | 1 |
| Daley, D | 1 |
| Selenke, W | 1 |
| Zahnd, GR | 1 |
| Luyckx, A | 1 |
| Walfish, PG | 1 |
| Natale, R | 1 |
| Chang, C | 1 |
| Lopez, N | 1 |
| Basabe, J | 1 |
| Krees, S | 1 |
| Terry, M | 1 |
| Charles, MA | 1 |
| Káldor, A | 1 |
| Pogátsa, G | 1 |
| Bradley, P | 1 |
| Settle, HP | 1 |
| Munsie, WJ | 1 |
| Owen, JA | 1 |
| Seltzer, HS | 1 |
| Allen, EW | 1 |
| Yannell, A | 1 |
| Drash, A | 1 |
| Langs, H | 1 |
| Blizzard, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diazoxide-mediated Insulin Suppression in Hyperinsulinemic Obese Men, Part III[NCT00631033] | Phase 2 | 51 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for diazoxide and Hyperglycemia, Postprandial
| Article | Year |
|---|---|
Diazoxide.
Topics: Blood Pressure; Cardiac Output; Diazoxide; Diuretics; Drug Synergism; Emergencies; Female; Half-Life | 1976 |
Mechanism of diazoxide hyperglycemia in animals.
Topics: Adrenal Glands; Animals; Blood Glucose; Catecholamines; Cyclic AMP; Diazoxide; Dogs; Drug Synergism; | 1968 |
Diazoxide and the treatment of hypoglycemia: an historical review.
Topics: Animals; Antihypertensive Agents; Diazoxide; Dogs; Drug Synergism; Glucose; Humans; Hyperglycemia; H | 1968 |
[Relationships between electrolyte balance and carbohydrate metabolism].
Topics: Animals; Carbohydrate Metabolism; Diazoxide; Glucocorticoids; Glycogen; Glycolysis; Humans; Hypergly | 1968 |
1 trial available for diazoxide and Hyperglycemia, Postprandial
| Article | Year |
|---|---|
High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention.
Topics: Adult; Blood Glucose; Body Mass Index; Body Weight; Diazoxide; Dose-Response Relationship, Drug; Dou | 2018 |
103 other studies available for diazoxide and Hyperglycemia, Postprandial
| Article | Year |
|---|---|
Diazoxide improves muscle function in association with improved dyslipidemia and decreased muscle oxidative stress in streptozotocin-induced diabetic rats.
Topics: Animals; Cholesterol; Diabetes Mellitus, Experimental; Diazoxide; Hyperglycemia; Lipids; Mice; Muscl | 2023 |
Medical therapy in patients with endogenous hypoglycaemia: Is euglycaemia achievable?
Topics: Adult; Aged; Blood Glucose; Blood Glucose Self-Monitoring; Diazoxide; Female; Glucocorticoids; Human | 2019 |
Hyperglycemia induces mechanical hyperalgesia and depolarization of the resting membrane potential of primary nociceptive neurons: Role of ATP-sensitive potassium channels.
Topics: Animals; Diazoxide; Diuretics; Ganglia, Spinal; Hyperalgesia; Hyperglycemia; KATP Channels; Male; Ma | 2019 |
Hyperglycemia-induced secretion of endothelial heparanase stimulates a vascular endothelial growth factor autocrine network in cardiomyocytes that promotes recruitment of lipoprotein lipase.
Topics: AMP-Activated Protein Kinases; Animals; Autocrine Communication; Blood Glucose; Calcium; Coronary Ve | 2013 |
Prolonged hyperglycemia & hyperinsulinemia increases BDNF mRNA expression in the posterior ventromedial hypothalamus and the dorsomedial hypothalamus of fed female rats.
Topics: Animals; Blood Glucose; Brain-Derived Neurotrophic Factor; Diazoxide; Dorsomedial Hypothalamic Nucle | 2015 |
Endothelial heparanase secretion after acute hypoinsulinemia is regulated by glucose and fatty acid.
Topics: Animals; Cattle; Cells, Cultured; Cytochalasin D; Cytoskeleton; Diazoxide; Disease Models, Animal; E | 2009 |
Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis.
Topics: Animals; Apoptosis; Benzoates; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Epoxide Hy | 2010 |
Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassembly.
Topics: Angiopoietin-Like Protein 4; Angiopoietins; Animals; Calnexin; Diabetes Mellitus, Experimental; Diaz | 2011 |
High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Glucose; Decanoic Acids; Diazoxide; Do | 2012 |
Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Age | 2012 |
Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Blood Glucose; Cell N | 2012 |
USE OF DIAZOXIDE WITH TRICHLORMETHIAZIDE FOR HYPERTENSION.
Topics: Acidosis; Antihypertensive Agents; Benzothiadiazines; Blood Pressure; Body Weight; Diazoxide; Hyperg | 1963 |
DIAZOXIDE HYPERGLYCAEMIA AND ITS CONTINUED RELIEF BY TOLBUTAMIDE.
Topics: Antihypertensive Agents; Diazoxide; Hyperglycemia; Pharmacology; Rats; Research; Tolbutamide | 1964 |
THE HYPERGLYCEMIC EFFECT OF HYPOTENSIVE DRUGS.
Topics: Antihypertensive Agents; Benzothiadiazines; Black People; Blood Glucose; Diazoxide; Guanethidine; Hu | 1964 |
AN ADRENERGIC MECHANISM FOR HYPERGLYCEMIA INDUCED BY DIAZOXIDE.
Topics: Adrenal Glands; Adrenalectomy; Adrenergic Agents; Antihypertensive Agents; Cyanides; Diazoxide; Dogs | 1965 |
Acute and chronic effects of glucose and carbachol on insulin secretion and phospholipase C activation: studies with diazoxide and atropine.
Topics: Animals; Atropine; Carbachol; Colforsin; Diazoxide; Enzyme Activation; Glucose; Hyperglycemia; In Vi | 2006 |
Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinism.
Topics: Adenosine Triphosphate; ATP-Binding Cassette Transporters; Child, Preschool; Diazoxide; Epinephrine; | 2005 |
Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats.
Topics: Animals; ATP-Binding Cassette Transporters; Blood Glucose; Brain; Diazoxide; Drug Combinations; Estr | 2007 |
The effect of altered carbohydrate metabolism in pertussis-sensitized mice on anaphylaxis.
Topics: Alloxan; Anaphylaxis; Animals; Blood Glucose; Body Weight; Diazoxide; Eating; Epinephrine; Female; G | 1967 |
Effect of diazoxide on glucose U-C-14 utilization in mice.
Topics: Adipose Tissue; Animals; Blood Glucose; Carbon Isotopes; Diazoxide; Epididymis; Fatty Acids; Glucose | 1967 |
Decrease of some metabolic and physiologic effects of diazoxide by propranolol in rat.
Topics: Animals; Blood Pressure; Cyclic AMP; Diazoxide; Drug Interactions; Female; Hyperglycemia; Liver; Pro | 1981 |
Development of insulin-dependent diabetes mellitus during the hemolytic-uremic syndrome.
Topics: Blood Glucose; Child; Child, Preschool; Diabetes Mellitus; Diabetic Ketoacidosis; Diazoxide; Female; | 1982 |
Neonatal hyperglycaemia after prolonged maternal treatment with diazoxide.
Topics: Adult; Diazoxide; Female; Humans; Hyperglycemia; Hypertension; Infant, Newborn; Infant, Newborn, Dis | 1982 |
Neonatal hyperglycemia following maternal diazoxide administration.
Topics: Adult; Blood Glucose; Diazoxide; Female; Humans; Hyperglycemia; Hypertension; Infant, Newborn; Infan | 1980 |
[Comparison of oral diazoxide and minoxidil in refractory hypertension].
Topics: Blood Glucose; Blood Pressure; Body Weight; Diazoxide; Diuretics; Drug Therapy, Combination; Electro | 1980 |
Diabetes and hyperglycemia impair activation of mitochondrial K(ATP) channels.
Topics: Analysis of Variance; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Coronary Circulation; | 2001 |
Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.
Topics: Animals; Colforsin; Diabetes Mellitus, Type 2; Diazoxide; Disease Models, Animal; Disease Susceptibi | 2001 |
An in Vitro system for studying insulin release caused by secretory granules-plasma membrane interaction: definition of the system.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Calcium; Carbohydrates; Cell Membrane; C | 1976 |
Treatment of hyperinsulinism after partial pancreatectomy: medical or surgical?
Topics: Adult; Diazoxide; Humans; Hyperglycemia; Hyperinsulinism; Male; Pancreatectomy | 1978 |
Diazoxide for the acute control of severe hypertension complicating pregnancy: a pilot study.
Topics: Adult; Diazoxide; Female; Fetal Heart; Heart Rate; Humans; Hyperglycemia; Hypertension; Infant, Newb | 1979 |
[Use of diazoxide in the treatment of severe hypertension].
Topics: Adult; Diazoxide; Humans; Hyperglycemia; Hypernatremia; Hypertension, Malignant; Male; Middle Aged | 1977 |
Growth hormone secretion and diazoxide induced hyperglycaemia.
Topics: Adult; Blood Glucose; Diazoxide; Growth Hormone; Humans; Hyperglycemia; Hypoglycemia; Male | 1978 |
[Hypertensive emergencies in children with renal hypertension (author's transl)].
Topics: Acute Disease; Acute Kidney Injury; Child; Child, Preschool; Diazoxide; Female; Glomerulonephritis; | 1979 |
On the mechanism of diazoxide-induced hyperglycemia.
Topics: Animals; Blood Glucose; Diazoxide; Dogs; Glucagon; Hyperglycemia; Insulin; Phentolamine; Somatostati | 1977 |
The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Dogs; Glucagon; Hyperglycemia; P | 1975 |
Cataracts in beagle dogs given diazoxide.
Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Cataract; Diazoxide; Dogs; Dose-Response Rela | 1975 |
Impact of uncoupling glucose stimulus from secretion on B-cell release and biosynthesis.
Topics: Animals; Diazoxide; Glucose; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets | 1992 |
Attenuated anomeric difference of glucose-induced insulin release in the perfused pancreas of diazoxide-treated rats.
Topics: Administration, Oral; Animals; Diazoxide; Female; Glucagon; Glucose; Hyperglycemia; Insulin; Pancrea | 1991 |
Coupling of beta-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats.
Topics: Animals; Blood Glucose; Diazoxide; Glucose; Hyperglycemia; Infusions, Intravenous; Insulin; Islets o | 1990 |
Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Diazoxide; Female; Glucose; Hyperglycemia; In Vitro Techni | 1987 |
[Hyperglycemic agents].
Topics: Blood Glucose; Chemical Phenomena; Chemistry; Diazoxide; Glucagon; Humans; Hyperglycemia; Hypoglycem | 1986 |
Diazoxide unmasks glucose inhibition of insulin release by counteracting entry of Ca2+.
Topics: Animals; Calcium; Diazoxide; Glucose; Glycolysis; Hyperglycemia; Insulin; Insulin Secretion; Islets | 1988 |
Diazoxide-induced long-term hyperglycemia. I. Preservation of B-cell insulin-releasing capacity.
Topics: Animals; Blood Glucose; Body Weight; Diazoxide; Female; Hyperglycemia; Insulin; Insulin Secretion; I | 1988 |
Severe non-ketotic hyperglycaemic pre-coma in a hypertensive patient receiving diazoxide.
Topics: Adult; Diazoxide; Humans; Hyperglycemia; Hypertension; Male | 1972 |
Refractory hypertension.
Topics: Administration, Oral; Antihypertensive Agents; Chronic Disease; Diazoxide; Drug Combinations; Drug R | 1973 |
Reversal of diazoxide effects by tolbutamide.
Topics: Animals; Blood Glucose; Blood Pressure; Diazoxide; Diuresis; Dogs; Ethacrynic Acid; Hyperglycemia; H | 1967 |
Experimental diabetes due to insulin inhibition.
Topics: Animals; Chlorothiazide; Diabetes Mellitus; Diazoxide; Haplorhini; Hyperglycemia; Hypoglycemia; Insu | 1968 |
A morphological study on the mechanism of diazoxide-hyperglycemia (clinical and experimental investigation).
Topics: Adenoma, Islet Cell; Adult; Animals; Child, Preschool; Cytoplasmic Granules; Diazoxide; Female; Gluc | 1969 |
[Studies in the rat on the problem of the diabetogenic effect of saluretics].
Topics: Acetazolamide; Animals; Benzothiadiazines; Blood Glucose; Chlorthalidone; Diazoxide; Glucose Toleran | 1965 |
Effects of diazoxide administration on plasma glucose, insulin, and lipids in Von Gierke's disease.
Topics: Antihypertensive Agents; Child; Diazoxide; Drug Eruptions; Drug Hypersensitivity; Glucose Tolerance | 1966 |
[Biochemical bases of diazoxide hyperglycemia].
Topics: Adrenal Glands; Adrenalectomy; Animals; Antihypertensive Agents; Diazoxide; Epinephrine; Ergotamine; | 1966 |
[Participation of insulin in diazoxide hyperglycemia].
Topics: Adenosine Triphosphate; Adrenal Glands; Animals; Antihypertensive Agents; Diabetes Mellitus, Experim | 1966 |
[Mechanism of increased glycogenolytic effect of diazoxide in potassium deficiency].
Topics: Animals; Antihypertensive Agents; Diazoxide; Enzymes; Esterases; Glucosyltransferases; Hyperglycemia | 1966 |
[The effect of hydrochlorthiazide on the blood sugar-increasing action of diazoxide].
Topics: Animals; Antihypertensive Agents; Carbohydrate Metabolism; Diazoxide; Hydrochlorothiazide; Hyperglyc | 1966 |
Biochemical aspects of the hyperglycemic action of diazoxide.
Topics: Adrenal Glands; Animals; Blood Glucose; Blood Pressure; Catecholamines; Cyclic AMP; Diazoxide; Gluco | 1968 |
The effects of diazoxide and benzothiadiazine diuretics upon phosphodiesterase.
Topics: Benzothiadiazines; Cyclic AMP; Diazoxide; Glycogen; Glycolysis; Humans; Hyperglycemia; Phosphoric Mo | 1968 |
Further studies on diazoxide suppression of insulin release from abnormal and normal islet tissue in man.
Topics: Adenoma, Islet Cell; Arginine; Blood Glucose; Catecholamines; Depression, Chemical; Diazoxide; Femal | 1968 |
Studies on diazoxide-induced hyperglycemia: an extrapancreatic mechanism.
Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; Child; Coloring Agents; Diabetes Mellitus; Diabetes | 1968 |
Clinical use of diazoxide and studies of the mechanism of its hyperglycemic effects in man.
Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Diabetes Mellitus; Diazoxide; Fatty Acids, Nonesterified; | 1968 |
Studies on the ability of compounds to block the diabetogenic activity of streptozotocin.
Topics: Amino Acids; Animals; Diabetes Mellitus; Diaphragm; Diazoxide; Epinephrine; Ethanol; Glucosamine; Gl | 1969 |
Transport of -aminoisobutyric acid in mammalian pancretic -cells.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Butyrates; Cyclic AMP; D | 1971 |
Effects of glucose and other modifiers of insulin release on the oxidative metabolism of amino acids in micro-dissected pancreatic islets.
Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Citrates; Cyclic AMP; Depression, Chemical | 1971 |
[Hyperglycemic coma without keto-acidosis in 2 hypertensive patients treated with intravenous diazoxide].
Topics: Aged; Diabetes Complications; Diabetes Mellitus; Diabetic Coma; Diazoxide; Female; Humans; Hyperglyc | 1973 |
Hypertension as a clinical problem: the hospital based population.
Topics: Adult; Age Factors; Antihypertensive Agents; Black People; Blood Pressure Determination; Camphor; Di | 1974 |
Effect of drugs on carbohydrate metabolism.
Topics: Adult; Blood Glucose; Caffeine; Carbohydrate Metabolism; Carbohydrate Metabolism, Inborn Errors; Chi | 1974 |
Intravenous diazoxide in the treatment of severe pre-eclamptic toxaemia and eclampsia.
Topics: Adolescent; Adult; Delivery, Obstetric; Diazepam; Diazoxide; Eclampsia; Female; Fetal Death; Humans; | 1973 |
Transport and storage of 5-hydroxytryptamine in pancreatic -cells.
Topics: Animals; Biological Transport; Carbon Isotopes; Chromatography, Gel; Diazoxide; Glucose; Glyburide; | 1972 |
Effect of single dose administration of diuretics on the blood sugar of alloxan-diabetic mice or mice made hyperglycaemic by the acute administration of diazoxide.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Diuresis; Diuretics; Drug Intera | 1973 |
Effect of diazoxide in plasma glucose and insulin concentrations after acute glycemic stimulation and intravenous tolbutamide.
Topics: Adult; Blood Glucose; Body Height; Body Weight; Diazoxide; Fasting; Female; Glucose Tolerance Test; | 1974 |
The action of diazoxide on insulin secretion, medullo-adrenal secretion, and the liberation of catecholamines.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Catecholamines; Diazoxide; Dogs; Epinephrine; Female; Hyper | 1968 |
Experimental and clinical studies with diazoxide.
Topics: Agammaglobulinemia; Animals; Blood Glucose; Diazoxide; Dogs; Edema; Epilepsy; Epinephrine; Female; H | 1968 |
Adenosine triphosphate levels of mammalian pancreatic B cells after stimulation with glucose and hypoglycemic sulfonylureas.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Female; Fluorometry; Glucose; Glycogen; Hyperglycemia; H | 1969 |
[Insulin secretion in vitro. II. Inhibition of glucose induced insulin release by diazoxide].
Topics: Animals; Culture Techniques; Diazoxide; Diuretics; Epinephrine; Glucose; Hyperglycemia; Insulin; Ins | 1966 |
Diabetes: underlying biochemical lesions.
Topics: Diabetes Mellitus; Diazoxide; Epinephrine; Female; Growth Hormone; Humans; Hyperglycemia; Insulin; I | 1970 |
The effect of experimental insulin deficiency on glucagon secretion.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diazoxide; Dogs; Glucagon; Heptoses; He | 1971 |
Calcium uptake by pancreatic -cells as measured with the aid of 45 Ca and mannitol- 3 H.
Topics: Animals; Biological Transport, Active; Calcium; Calcium Isotopes; Diazoxide; Dinitrophenols; Female; | 1971 |
[Analysis of the mechanisms implicated in the hyperglycemic action of diazoxide].
Topics: Animals; Antihypertensive Agents; Benzothiadiazines; Blood Glucose; Diazoxide; Dogs; Hyperglycemia | 1966 |
Acute diabetic ketoacidosis--a complication of intravenous diazoxide treatment for refractory hypertension.
Topics: Adult; Diabetic Ketoacidosis; Diazoxide; Female; Humans; Hyperglycemia; Hypertension; Injections, In | 1969 |
Mode of action of a diazoxide analog (A025). Its effects on insulin secretion.
Topics: Adrenal Glands; Animals; Autoanalysis; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Catechola | 1970 |
Levels of -ketoglutarate and glutamate in stimulated pancreatic -cells.
Topics: Animals; Carbutamide; Chemical Phenomena; Chemistry; Depression, Chemical; Diazoxide; Female; Fluoro | 1970 |
Uptake of alanine, arginine and leucine by mammalian pancreatic beta-cells.
Topics: Alanine; Animals; Arginine; Carbon Isotopes; Diazoxide; Fructose; Glucose; Glyburide; Hyperglycemia; | 1971 |
Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy.
Topics: Acute Disease; Administration, Oral; Adult; Albuminuria; Blood Glucose; Diazoxide; Female; Furosemid | 1972 |
The influences of rate of injection upon the effects of diazoxide.
Topics: Adult; Aged; Aminohippuric Acids; Blood Pressure; Chlorides; Creatinine; Diazoxide; Female; Humans; | 1972 |
Diazoxide misunderstood.
Topics: Diazoxide; Humans; Hyperglycemia | 1972 |
Dangers of diazoxide.
Topics: Abnormalities, Drug-Induced; Diazoxide; Female; Hair; Humans; Hyperglycemia; Hypertension; Pregnancy | 1972 |
[Hyperglycemic coma without ketoacidosis in 2 hypertensive patients treated with intravenous diazoxide].
Topics: Aged; Coma; Diazoxide; Female; Glucose Tolerance Test; Humans; Hyperglycemia; Hypertension; Hyperten | 1972 |
Use of diazoxide in hypertension with renal failure.
Topics: Adolescent; Adult; Blood Glucose; Creatine; Diazoxide; Dietary Proteins; Female; Humans; Hyperglycem | 1971 |
Intravenous diazoxide for severe hypertension in childhood.
Topics: Adolescent; Blood Pressure; Child; Child, Preschool; Diazoxide; Female; Glomerulonephritis; Humans; | 1971 |
Hyperglycemia after diazoxide.
Topics: Coma; Diazoxide; Furosemide; Humans; Hyperglycemia; Injections, Intravenous; Tolbutamide | 1971 |
The use of diazoxide in hypertensive crises with particular reference to the control of hypertension in severe renal failure.
Topics: Acute Kidney Injury; Antihypertensive Agents; Blood Pressure; Depression, Chemical; Diazoxide; Femal | 1971 |
The clinical use of diazoxide in leucine-sensitive hypoglycemia.
Topics: Amino Acid Metabolism, Inborn Errors; Child, Preschool; Diazoxide; Female; Humans; Hyperglycemia; Hy | 1968 |
The effect of agents used in the treatment of bronchial asthma on carbohydrate metabolism and histamine sensitivity after beta-adrenergic blockade.
Topics: Adenine Nucleotides; Adrenal Cortex Hormones; Adrenalectomy; Alloxan; Aminophylline; Animals; Antige | 1970 |
[Diabetogenic activity of diazoxide].
Topics: Diabetes Mellitus; Diazoxide; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Insulin Secret | 1966 |
Studies concerning the hyperglycemic effects of diazoxide and its mode of action.
Topics: Adrenal Glands; Adrenalectomy; Animals; Antihypertensive Agents; Diazoxide; Glucose Tolerance Test; | 1965 |
Beta adrenergic receptor mechanisms in the metabolic effects of diazoxide in fasted rats.
Topics: Animals; Blood Glucose; Diazoxide; Fasting; Glycerides; Hyperglycemia; Lactates; Plasma; Propranolol | 1970 |
AO44: an improved hyperglycemic agent.
Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Diazoxide; Diuresis; Dogs; Epinephrine | 1971 |
Nonketoacidotic hyperglycemia and coma during intravenous diazoxide therapy in uremia.
Topics: Adult; Depression, Chemical; Diabetic Coma; Diazoxide; Female; Glucose; Humans; Hyperglycemia; Hyper | 1971 |
[Data on the mechanism of the diabetogenic effect of chlorothiazides].
Topics: Animals; Chlorothiazide; Diazoxide; Furosemide; Gluconeogenesis; Hydrochlorothiazide; Hyperglycemia; | 1967 |
The hyperglycemic and antidiuretic activity of a phthalimidine analogue: 1-oxo-3-(4'-chlorophenyl)-3-hydroxyisoindoline (C3-176).
Topics: Animals; Blood Glucose; Blood Pressure; Catecholamines; Chlorthalidone; Diazoxide; Diuresis; Dogs; F | 1968 |
Toxic effects of a chlorothiazide-diazoxide combination on adipose tissue and kidneys of intact rats.
Topics: Adipose Tissue; Animals; Carbon Isotopes; Chlorothiazide; Culture Techniques; Diazoxide; Epididymis; | 1968 |
Hyperglycemia and inhibition of insulin secretion during administration of diazoxide and trichlormethiazide in man.
Topics: Blood Glucose; Diabetes Mellitus; Diazoxide; Drug Synergism; Glucose Tolerance Test; Humans; Hypergl | 1969 |
The hyperglycemic activity of benzothiadiazine and other diuretics.
Topics: Animals; Bendroflumethiazide; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Diazoxide; Diuretic | 1965 |
Diazoxide-induced diabetes mellitus in a hypopituitary dwarf.
Topics: Acidosis; Antihypertensive Agents; Child; Diabetes Complications; Diazoxide; Dwarfism, Pituitary; Fe | 1966 |