diazoxide has been researched along with Hyperammonemia in 5 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Hyperammonemia: Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This syndrome is caused by dominantly expressed mutations of the glutamate dehydrogenase gene (10q23." | 5.32 | [Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide]. ( Argente Oliver, J; Donoso, MA; Martos Moreno, G; Montero Luis, C; Muñoz Calvo, MT; Pozo Román, J; Rubio Cabezas, O, 2004) |
| "This syndrome is characterised by recurrent episodes of hypoglycaemia and elevated ammonia levels, which are potentially harmful to both the patient and a developing fetus." | 1.56 | Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome. ( Bazelmans, M; Benner, BJM; Huidekoper, H; Langendonk, J; Langeveld, M; Schoenmakers, S, 2020) |
| "This syndrome is caused by dominantly expressed mutations of the glutamate dehydrogenase gene (10q23." | 1.32 | [Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide]. ( Argente Oliver, J; Donoso, MA; Martos Moreno, G; Montero Luis, C; Muñoz Calvo, MT; Pozo Román, J; Rubio Cabezas, O, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brandt, A | 1 |
| Agarwal, N | 1 |
| Giri, D | 1 |
| Yung, Z | 1 |
| Didi, M | 1 |
| Senniappan, S | 1 |
| Benner, BJM | 1 |
| Bazelmans, M | 1 |
| Huidekoper, H | 1 |
| Langeveld, M | 1 |
| Langendonk, J | 1 |
| Schoenmakers, S | 1 |
| Roy, K | 1 |
| Satapathy, AK | 1 |
| Houhton, JAL | 1 |
| Flanagan, SE | 1 |
| Radha, V | 1 |
| Mohan, V | 1 |
| Sharma, R | 1 |
| Jain, V | 1 |
| Montero Luis, C | 1 |
| Pozo Román, J | 1 |
| Muñoz Calvo, MT | 1 |
| Martos Moreno, G | 1 |
| Donoso, MA | 1 |
| Rubio Cabezas, O | 1 |
| Argente Oliver, J | 1 |
| Kelly, A | 1 |
| Ng, D | 1 |
| Ferry, RJ | 1 |
| Grimberg, A | 1 |
| Koo-McCoy, S | 1 |
| Thornton, PS | 1 |
| Stanley, CA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Vitamin E in Hyperinsulinism/Hyperammonemia Syndrome[NCT04984798] | Phase 2 | 0 participants (Actual) | Interventional | 2022-11-30 | Withdrawn (stopped due to No study activity took place. The IND was withdrawn with the FDA by the Sponsor Investigator because of insurmountable hurdles in moving proposed research forward) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for diazoxide and Hyperammonemia
| Article | Year |
|---|---|
Hyperinsulinism hyperammonaemia (HI/HA) syndrome due to GLUD1 mutation: phenotypic variations ranging from late presentation to spontaneous resolution.
Topics: Ammonia; Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Glutamate Dehydrogenase; Humans; | 2020 |
Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome.
Topics: Adult; Diazoxide; Diet, Carbohydrate Loading; Directive Counseling; Female; Humans; Hyperammonemia; | 2020 |
Congenital Hyperinsulinemic Hypoglycemia and Hyperammonemia due to Pathogenic Variants in GLUD1.
Topics: Congenital Hyperinsulinism; Diazoxide; Female; Genetic Predisposition to Disease; Glutamate Dehydrog | 2019 |
[Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide].
Topics: Diazoxide; Glutamate Dehydrogenase; Humans; Hyperammonemia; Hyperinsulinism; Infant; Male; Mutation; | 2004 |
Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome.
Topics: Adolescent; Adult; Amino Acid Substitution; Ammonia; Blood Glucose; Child; Child, Preschool; Diazoxi | 2001 |