diazoxide has been researched along with Heart Disease, Ischemic in 61 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twelve pigs were randomized to global ischemia for 2 hours with a single dose of cold blood (4:1) hyperkalemic cardioplegia alone (n = 6) or with diazoxide (500 μmol/L) (n = 6) and reperfused for 1 hour." | 8.12 | Diazoxide preserves myocardial function in a swine model of hypothermic cardioplegic arrest and prolonged global ischemia. ( Brady, MB; Cho, BC; Dodd-O, JM; Gaughan, N; Jones, M; Kearney, S; Lawton, JS; Lui, C; Metkus, TS; Suarez-Pierre, A; Thomas, RP; Wang, J; Zhou, X, 2022) |
| "Twelve pigs were randomized to global ischemia for 2 hours with a single dose of cold blood (4:1) hyperkalemic cardioplegia alone (n = 6) or with diazoxide (500 μmol/L) (n = 6) and reperfused for 1 hour." | 4.12 | Diazoxide preserves myocardial function in a swine model of hypothermic cardioplegic arrest and prolonged global ischemia. ( Brady, MB; Cho, BC; Dodd-O, JM; Gaughan, N; Jones, M; Kearney, S; Lawton, JS; Lui, C; Metkus, TS; Suarez-Pierre, A; Thomas, RP; Wang, J; Zhou, X, 2022) |
| " We explored the involvement of phosphatidylinositol 3-kinase (PI3K)/Akt in the PC-like effect of mitoKATP opener diazoxide with particular regard to its role in protection against ischaemia-induced arrhythmias." | 3.75 | Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms. ( Carnická, S; Kolár, F; Matejíková, J; Pancza, D; Ravingerová, T, 2009) |
| "Right atrial sections from four patient groups-non-diabetic, insulin-dependent diabetes mellitus (IDDM), non-insulin-dependent diabetes mellitus (NIDDM) receiving glibenclamide, and NIDDM receiving metformin-were subjected to one of the following protocols: aerobic control, simulated ischemia/reoxygenation, ischemic preconditioning before ischemia, and pharmacological preconditioning with alpha 1 agonist phenylephrine, adenosine, the mito-K(ATP) channel opener diazoxide, the protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA), or the p38 mitogen-activated protein kinase (p38MAPK) activator anisomycin." | 3.73 | Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium. ( Fowler, A; Galiñanes, M; Hassouna, A; Loubani, M; Matata, BM; Standen, NB, 2006) |
| "Diazoxide has been identified over the past 50years to have a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia." | 2.49 | Multiplicity of effectors of the cardioprotective agent, diazoxide. ( Coetzee, WA, 2013) |
| "Glibenclamide (10 μM) terminated these arrhythmias and restored APDs to control values." | 1.37 | Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. ( Ambrosi, CM; Chang, R; Efimov, IR; Fedorov, VV; Glukhov, AV; Janks, D; Kostecki, G; Moazami, N; Nichols, CG; Schuessler, RB, 2011) |
| "In diazoxide- treated hearts, diazoxide (50 micromol/l) was applied 15 min before II." | 1.34 | Changes in rat myocardium associated with modulation of ischemic tolerance by diazoxide. ( Andelová, E; Barancík, M; Ravingerová, T; Simoncíková, P; Tribulová, N, 2007) |
| "Diazoxide (DIAZ) has been shown to be neuroprotective in animal models of different brain pathologies." | 1.34 | Diazoxide is protective in the rat retina against ischemic injury induced by bilateral carotid occlusion and glutamate-induced degeneration. ( Atlasz, T; Babai, N; Bari, F; Domoki, F; Gabriel, R; Kiss, P; Reglodi, D; Tamas, A, 2007) |
| " Therefore, pharmacological preconditioning with diazoxide in combination with adenosine and a nitric oxide donor (triple-combination pharmacological preconditioning) may enhance cardioprotection." | 1.32 | Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor. ( Imamura, H; Kido, M; Nakao, S; Ninomiya, H; Okada, T; Otani, H; Shingu, K; Uchiyama, T; Uchiyama, Y, 2003) |
| "Glimepiride (Glim) is a new sulfonylurea reported to affect nonpancreatic K(ATP) channels less than does Glib." | 1.31 | Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide. ( Baxter, GF; Lawrence, CL; Maddock, HL; Mocanu, MM; Standen, NB; Yellon, DM, 2001) |
| "Diazoxide pretreatment significantly improved the recovery of LV function and coronary flow compared to control (LVDP: 49 +/- 5* vs." | 1.31 | Diazoxide protects the rabbit heart following cardioplegic ischemia. ( Feng, J; Li, H; Rosenkranz, ER, 2002) |
| "Diazoxide (1 mg/kg) was administered either 30 min (for EP) or 24 h (DP) before 30 min of lethal ischemia." | 1.30 | Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide. ( Brown, M; Emani, VR; Krottapalli, K; Kukreja, RC; Ockaili, R; Okubo, S, 1999) |
| "Pretreatment with diazoxide (10 mg." | 1.29 | Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats. ( Ichihara, K; Nakai, T, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (8.20) | 18.2507 |
| 2000's | 51 (83.61) | 29.6817 |
| 2010's | 4 (6.56) | 24.3611 |
| 2020's | 1 (1.64) | 2.80 |
| Authors | Studies |
|---|---|
| Coghlan, MJ | 1 |
| Carroll, WA | 1 |
| Gopalakrishnan, M | 1 |
| Breschi, MC | 2 |
| Calderone, V | 3 |
| Digiacomo, M | 3 |
| Manganaro, M | 2 |
| Martelli, A | 3 |
| Minutolo, F | 1 |
| Rapposelli, S | 3 |
| Testai, L | 3 |
| Tonelli, F | 1 |
| Balsamo, A | 2 |
| Cirilli, R | 1 |
| Faggi, C | 1 |
| La Torre, F | 1 |
| Vanni, M | 1 |
| Suarez-Pierre, A | 1 |
| Lui, C | 1 |
| Zhou, X | 1 |
| Kearney, S | 1 |
| Jones, M | 1 |
| Wang, J | 2 |
| Thomas, RP | 1 |
| Gaughan, N | 1 |
| Metkus, TS | 1 |
| Brady, MB | 1 |
| Cho, BC | 1 |
| Dodd-O, JM | 1 |
| Lawton, JS | 3 |
| Coetzee, WA | 1 |
| Janjua, MB | 1 |
| Makepeace, CM | 1 |
| Anastacio, MM | 1 |
| Schuessler, RB | 3 |
| Nichols, CG | 2 |
| Srisakuldee, W | 1 |
| Jeyaraman, MM | 1 |
| Nickel, BE | 1 |
| Tanguy, S | 1 |
| Jiang, ZS | 1 |
| Kardami, E | 1 |
| Matejíková, J | 1 |
| Ravingerová, T | 2 |
| Pancza, D | 1 |
| Carnická, S | 1 |
| Kolár, F | 1 |
| Cao, H | 1 |
| Chen, XX | 1 |
| Gui, B | 1 |
| Duan, SM | 1 |
| Zeng, YM | 1 |
| Fedorov, VV | 1 |
| Glukhov, AV | 1 |
| Ambrosi, CM | 1 |
| Kostecki, G | 1 |
| Chang, R | 1 |
| Janks, D | 1 |
| Moazami, N | 1 |
| Efimov, IR | 1 |
| Hausenloy, DJ | 2 |
| Maddock, HL | 2 |
| Baxter, GF | 2 |
| Yellon, DM | 4 |
| Peart, J | 1 |
| Willems, L | 1 |
| Headrick, JP | 1 |
| Legtenberg, RJ | 1 |
| Rongen, GA | 1 |
| Houston, RJ | 1 |
| Oeseburg, B | 1 |
| Smits, P | 1 |
| Lim, KH | 1 |
| Javadov, SA | 1 |
| Das, M | 1 |
| Clarke, SJ | 1 |
| Suleiman, MS | 1 |
| Halestrap, AP | 1 |
| Suzuki, M | 1 |
| Saito, T | 1 |
| Sato, T | 3 |
| Tamagawa, M | 1 |
| Miki, T | 3 |
| Seino, S | 1 |
| Nakaya, H | 1 |
| Korge, P | 1 |
| Honda, HM | 1 |
| Weiss, JN | 1 |
| Uchiyama, Y | 1 |
| Otani, H | 1 |
| Okada, T | 1 |
| Uchiyama, T | 1 |
| Ninomiya, H | 1 |
| Kido, M | 1 |
| Imamura, H | 1 |
| Nakao, S | 1 |
| Shingu, K | 1 |
| Oldenburg, O | 1 |
| Yang, XM | 1 |
| Krieg, T | 1 |
| Garlid, KD | 2 |
| Cohen, MV | 1 |
| Grover, GJ | 1 |
| Downey, JM | 1 |
| McCully, JD | 4 |
| Levitsky, S | 4 |
| Wakahara, N | 1 |
| Katoh, H | 1 |
| Yaguchi, Y | 1 |
| Uehara, A | 1 |
| Satoh, H | 1 |
| Terada, H | 1 |
| Fujise, Y | 1 |
| Hayashi, H | 1 |
| Loubani, M | 2 |
| Hassouna, A | 2 |
| Galiñanes, M | 3 |
| O'Rourke, B | 4 |
| Hausenloy, D | 1 |
| Wynne, A | 1 |
| Duchen, M | 1 |
| Yellon, D | 1 |
| Wang, Y | 4 |
| Ahmad, N | 2 |
| Kudo, M | 1 |
| Ashraf, M | 4 |
| Wei, K | 1 |
| Min, S | 1 |
| Long, C | 1 |
| Harada, N | 1 |
| Miura, T | 3 |
| Dairaku, Y | 1 |
| Kametani, R | 1 |
| Shibuya, M | 1 |
| Wang, R | 1 |
| Kawamura, S | 1 |
| Matsuzaki, M | 1 |
| Beresewicz, A | 1 |
| Maczewski, M | 1 |
| Duda, M | 1 |
| Rousou, AJ | 2 |
| Ericsson, M | 1 |
| Federman, M | 1 |
| Er, F | 1 |
| Michels, G | 1 |
| Gassanov, N | 1 |
| Rivero, F | 1 |
| Hoppe, UC | 1 |
| Kristiansen, SB | 1 |
| Nielsen-Kudsk, JE | 1 |
| Bøtker, HE | 1 |
| Nielsen, TT | 1 |
| Matata, BM | 1 |
| Fowler, A | 1 |
| Standen, NB | 3 |
| Naitoh, K | 1 |
| Ichikawa, Y | 1 |
| Nakamura, Y | 1 |
| Ikeda, Y | 1 |
| Kobayashi, H | 1 |
| Nishihara, M | 1 |
| Ohori, K | 1 |
| Shimamoto, K | 2 |
| Haider, KH | 1 |
| Wang, B | 1 |
| Pasha, Z | 1 |
| Uzun, O | 1 |
| Toyoda, Y | 2 |
| Wakiyama, H | 1 |
| Parker, RA | 1 |
| Pasdois, P | 1 |
| Beauvoit, B | 1 |
| Tariosse, L | 2 |
| Vinassa, B | 1 |
| Bonoron-Adèle, S | 1 |
| Santos, PD | 1 |
| Gao, H | 1 |
| Chen, L | 1 |
| Yang, HT | 1 |
| Lim, SY | 1 |
| Davidson, SM | 1 |
| Schulz, R | 1 |
| Boengler, K | 1 |
| Totzeck, A | 1 |
| Luo, Y | 1 |
| Garcia-Dorado, D | 1 |
| Heusch, G | 1 |
| Simoncíková, P | 1 |
| Andelová, E | 1 |
| Tribulová, N | 1 |
| Barancík, M | 1 |
| Al-Dadah, AS | 1 |
| Voeller, RK | 1 |
| Damiano, RJ | 1 |
| Rosenkranz, ER | 2 |
| Atlasz, T | 1 |
| Babai, N | 1 |
| Reglodi, D | 1 |
| Kiss, P | 1 |
| Tamas, A | 1 |
| Bari, F | 1 |
| Domoki, F | 1 |
| Gabriel, R | 1 |
| Nakai, T | 1 |
| Ichihara, K | 1 |
| Liu, Y | 2 |
| Marban, E | 3 |
| Seharaseyon, J | 1 |
| Szewczyk, A | 1 |
| Ockaili, R | 1 |
| Emani, VR | 1 |
| Okubo, S | 1 |
| Brown, M | 1 |
| Krottapalli, K | 1 |
| Kukreja, RC | 1 |
| Iwai, T | 1 |
| Tanonaka, K | 1 |
| Koshimizu, M | 1 |
| Takeo, S | 1 |
| Ghosh, S | 1 |
| Pomerantz, BJ | 1 |
| Robinson, TN | 1 |
| Morrell, TD | 1 |
| Heimbach, JK | 1 |
| Banerjee, A | 1 |
| Harken, AH | 1 |
| Kevelaitis, E | 1 |
| Oubénaissa, A | 1 |
| Mouas, C | 1 |
| Peynet, J | 1 |
| Menasché, P | 1 |
| Imahashi, K | 1 |
| Nishimura, T | 1 |
| Yoshioka, J | 1 |
| Kusuoka, H | 1 |
| Mocanu, MM | 1 |
| Lawrence, CL | 1 |
| Takashi, E | 1 |
| Xu, M | 1 |
| Ayub, A | 1 |
| Schulman, D | 1 |
| Latchman, DS | 1 |
| Murata, M | 1 |
| Akao, M | 1 |
| Dos Santos, P | 1 |
| Kowaltowski, AJ | 1 |
| Laclau, MN | 1 |
| Seetharaman, S | 1 |
| Paucek, P | 1 |
| Boudina, S | 1 |
| Thambo, JB | 1 |
| Ohnuma, Y | 1 |
| Tanno, M | 1 |
| Kuno, A | 1 |
| Tsuchida, A | 1 |
| Feng, J | 1 |
| Li, H | 1 |
6 reviews available for diazoxide and Heart Disease, Ischemic
| Article | Year |
|---|---|
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
Topics: Adenosine Triphosphate; Angina Pectoris; Arrhythmias, Cardiac; Asthma; Calcium; Ion Channel Gating; | 2001 |
Multiplicity of effectors of the cardioprotective agent, diazoxide.
Topics: Animals; Cardiotonic Agents; Diazoxide; Humans; Insulin-Secreting Cells; KATP Channels; Mitochondria | 2013 |
Mitochondrial ATP-sensitive potassium channels in surgical cardioprotection.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cardiotonic Agents; Diazoxide; Disease Models, Animal; H | 2003 |
Evidence for mitochondrial K+ channels and their role in cardioprotection.
Topics: Adenosine; Animals; Cattle; Diazoxide; Energy Metabolism; Humans; Ion Transport; Ischemic Preconditi | 2004 |
Connexin 43 in ischemic pre- and postconditioning.
Topics: Connexin 43; Diazoxide; Humans; Ischemic Preconditioning, Myocardial; Mitochondria; Mitochondrial Me | 2007 |
Mitochondrial ATP-dependent potassium channels. Viable candidate effectors of ischemic preconditioning.
Topics: Animals; Decanoic Acids; Diazoxide; Heart; Hydroxy Acids; Intracellular Membranes; Ischemic Precondi | 1999 |
55 other studies available for diazoxide and Heart Disease, Ischemic
| Article | Year |
|---|---|
Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel.
Topics: Animals; Benzopyrans; Blood Pressure; KATP Channels; Male; Mitochondria; Molecular Structure; Myocar | 2008 |
Enantioselectivity in cardioprotection induced by (S)- (-)-2,2-dimethyl-N-(4'-acetamido-benzyl)-4-spiromorpholone-chromane.
Topics: Animals; Benzopyrans; Cardiotonic Agents; Chromatography, High Pressure Liquid; Circular Dichroism; | 2009 |
Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia.
Topics: Animals; Benzopyrans; Cardiotonic Agents; Cell Line; KATP Channels; Male; Myocardial Ischemia; Myocy | 2011 |
Diazoxide preserves myocardial function in a swine model of hypothermic cardioplegic arrest and prolonged global ischemia.
Topics: Adenosine Triphosphate; Animals; Cardioplegic Solutions; Diazoxide; Heart Arrest, Induced; Ischemia; | 2022 |
Cardioprotective benefits of adenosine triphosphate-sensitive potassium channel opener diazoxide are lost with administration after the onset of stress in mouse and human myocytes.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Diazoxide; Disease Models, Animal; Female; Heart A | 2014 |
Phosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resistant state.
Topics: Amino Acid Substitution; Animals; Connexin 43; Diazoxide; Fibroblast Growth Factor 2; Gene Expressio | 2009 |
Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms.
Topics: Androstadienes; Animals; Arrhythmias, Cardiac; Diazoxide; Mitochondria, Heart; Myocardial Ischemia; | 2009 |
[The effects of diazoxide on myocardium function and the expressions of ERK and JNK in isolated spontaneous hypertension rat hearts].
Topics: Animals; Diazoxide; In Vitro Techniques; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Myo | 2006 |
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.
Topics: Action Potentials; Adolescent; Adult; Arrhythmias, Cardiac; Coronary Vessels; Diazoxide; Female; Gen | 2011 |
Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?
Topics: Adenosine; Analysis of Variance; Animals; Atractyloside; Calcineurin Inhibitors; Cyclosporine; Decan | 2002 |
Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine.
Topics: Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; Cardiotonic Agents; Diazoxide; Drug Ad | 2003 |
The role of myocardial KATP-channel blockade in the protective effects of glibenclamide against ischaemia in the rat heart.
Topics: Animals; Coronary Circulation; Diazoxide; Drug Interactions; Glyburide; Male; Myocardial Ischemia; P | 2002 |
The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration.
Topics: Acyl Coenzyme A; Animals; Decanoic Acids; Diazoxide; Heart; Hydroxy Acids; Ischemic Preconditioning, | 2002 |
Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzamides; Cardiotonic Agents; Diazoxide; In Vi | 2003 |
Effects of fatty acids in isolated mitochondria: implications for ischemic injury and cardioprotection.
Topics: Adenosine Triphosphate; Animals; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell M | 2003 |
Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor.
Topics: Adenosine; Animals; Combined Modality Therapy; Coronary Circulation; Creatine Kinase; Diazoxide; Dis | 2003 |
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
Topics: Animals; Brain Chemistry; Decanoic Acids; Diazoxide; Glyburide; Guanidines; Hydroxy Acids; Ischemic | 2003 |
Difference in the cardioprotective mechanisms between ischemic preconditioning and pharmacological preconditioning by diazoxide in rat hearts.
Topics: Animals; ATP-Binding Cassette Transporters; Cardiotonic Agents; Diazoxide; Energy Metabolism; Hydrog | 2004 |
Delayed preconditioning of the human myocardium: signal transduction and clinical implications.
Topics: Acetylcholine; Aged; Alkaloids; Anisomycin; Antihypertensive Agents; Benzophenanthridines; Culture T | 2004 |
Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection.
Topics: 2,4-Dinitrophenol; Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Anima | 2004 |
Contribution of Akt and endothelial nitric oxide synthase to diazoxide-induced late preconditioning.
Topics: Animals; Apoptosis; Coronary Circulation; Diazoxide; Hemodynamics; Ischemic Preconditioning, Myocard | 2004 |
Cardioprotective effects of mitochondrial KATP channels activated at different time.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Female; Ischemic Preconditioning, Myocardial; Male; Memb | 2004 |
NO donor-activated PKC-delta plays a pivotal role in ischemic myocardial protection through accelerated opening of mitochondrial K-ATP channels.
Topics: Animals; Antihypertensive Agents; Diazoxide; Enzyme Activation; Heart Rate; Isoenzymes; Membrane Pro | 2004 |
Effect of classic preconditioning and diazoxide on endothelial function and O2- and NO generation in the post-ischemic guinea-pig heart.
Topics: Animals; Benzamides; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Endothelium, Vascu | 2004 |
Opening of mitochondrial KATP channels enhances cardioprotection through the modulation of mitochondrial matrix volume, calcium accumulation, and respiration.
Topics: Adenosine Triphosphate; Animals; Calcium; Cardioplegic Solutions; Cardiotonic Agents; Diazoxide; Dru | 2004 |
Testosterone induces cytoprotection by activating ATP-sensitive K+ channels in the cardiac mitochondrial inner membrane.
Topics: Adenosine Triphosphate; Androgen Receptor Antagonists; Androstenedione; Animals; Biological Transpor | 2004 |
Effects of KATP channel modulation on myocardial glycogen content, lactate, and amino acids in nonischemic and ischemic rat hearts.
Topics: Alanine; Amino Acids; Animals; Diazoxide; Drug Interactions; Glutamic Acid; Glyburide; Glycogen; Lac | 2005 |
Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium.
Topics: Adenosine; Adrenergic alpha-Agonists; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitu | 2006 |
MitoKATP channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Cell Membrane Permeability; Connexin 43; Diazoxide; Enzyme Inhibito | 2006 |
Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning.
Topics: Androstadienes; Animals; Apoptosis; Benzopyrans; Blotting, Western; Cardiotonic Agents; Cytosol; Dia | 2006 |
Age- and gender-related differences in ischemia/reperfusion injury and cardioprotection: effects of diazoxide.
Topics: Aging; Animals; Cardioplegic Solutions; Cardiotonic Agents; Cerebral Infarction; Diazoxide; Disease | 2006 |
MitoK(ATP)-dependent changes in mitochondrial volume and in complex II activity during ischemic and pharmacological preconditioning of Langendorff-perfused rat heart.
Topics: Adenosine Diphosphate; Animals; Antihypertensive Agents; Cell Respiration; Decanoic Acids; Diazoxide | 2006 |
Activation of alpha1B-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca2+ overload in cardiomyocytes.
Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Anima | 2007 |
Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore.
Topics: Animals; Bradykinin; Cyclophilins; Cyclosporine; Diazoxide; Enzyme Inhibitors; Female; Ischemic Prec | 2007 |
Changes in rat myocardium associated with modulation of ischemic tolerance by diazoxide.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Diazoxide; Enzyme Activation; Extracellular Signal | 2007 |
Maintenance of myocyte volume homeostasis during stress by diazoxide is cardioprotective.
Topics: Adenosine Triphosphate; Animals; Calcium; Cardiac Volume; Diazoxide; Female; Homeostasis; Male; Myoc | 2007 |
Invited commentary.
Topics: Animals; Diazoxide; Myocardial Contraction; Myocardial Ischemia; Myocytes, Cardiac; Potassium Channe | 2007 |
Diazoxide is protective in the rat retina against ischemic injury induced by bilateral carotid occlusion and glutamate-induced degeneration.
Topics: Animals; Animals, Newborn; Cell Count; Diazoxide; Disease Models, Animal; Drug Interactions; Glutami | 2007 |
Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Calcium; Diazoxide; Disease Models, Animal; Dose-Res | 1994 |
Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection?
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Diazoxide; Flavoproteins; Fluorescence; Heart Vent | 1998 |
Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca2+ overload injury in rat myocardium.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium; Calcium Channel Blockers; | 1999 |
Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Coronary Vessels; Decanoic Acids; Diazoxide | 1999 |
Preservation of mitochondrial function by diazoxide during sustained ischaemia in the rat heart.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Creatine Kinase; Diazoxide; Diuretics; Energy | 2000 |
Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning.
Topics: Analysis of Variance; Cell Membrane; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Gl | 2000 |
Selective mitochondrial adenosine triphosphate-sensitive potassium channel activation is sufficient to precondition human myocardium.
Topics: Adenosine; Adenosine Triphosphate; Analysis of Variance; Creatine Kinase; Diazoxide; Humans; Mitocho | 2000 |
Ischemic preconditioning with opening of mitochondrial adenosine triphosphate-sensitive potassium channels or Na/H exchange inhibition: which is the best protective strategy for heart transplants?
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Creatine Kinase; Diaz | 2001 |
Opening of mitochondrial ATP-sensitive potassium channels enhances cardioplegic protection.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Cardioplegic Solutions; Diazoxide; Disease Mo | 2001 |
Role of intracellular Na(+) kinetics in preconditioned rat heart.
Topics: Animals; Decanoic Acids; Diazoxide; Hydroxy Acids; In Vitro Techniques; Intracellular Fluid; Ischemi | 2001 |
Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide.
Topics: Animals; Diazoxide; Glyburide; Guanosine Triphosphate; Heart; Heart Ventricles; Hemodynamics; Hypogl | 2001 |
Downregulation of protein kinase C inhibits activation of mitochondrial K(ATP) channels by diazoxide.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Dose-Response Relationship, Drug; Down-Regulation; Immun | 2001 |
Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.
Topics: Adenosine; Aging; Animals; Diazoxide; Diglycerides; Heart; Ischemic Preconditioning, Myocardial; Mal | 2001 |
Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection.
Topics: Bongkrekic Acid; Calcium; Cell Separation; Cytoprotection; Decanoic Acids; Diazoxide; Dose-Response | 2001 |
Mechanisms by which opening the mitochondrial ATP- sensitive K(+) channel protects the ischemic heart.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Respiration; Creatine; Diazoxide; Hemod | 2002 |
Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Diazoxide; Enzyme Activation; Hemodynamics; Hydroxy | 2002 |
Diazoxide protects the rabbit heart following cardioplegic ischemia.
Topics: Animals; Anti-Arrhythmia Agents; Cardioplegic Solutions; Coronary Circulation; Decanoic Acids; Diast | 2002 |