Page last updated: 2024-10-25

diazoxide and Fasting Hypoglycemia

diazoxide has been researched along with Fasting Hypoglycemia in 340 studies

Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.

Fasting Hypoglycemia: HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast.

Research Excerpts

ExcerptRelevanceReference
"Diazoxide is the first-line drug for treating hyperinsulinism and the only pharmacological agent approved for hyperinsulinism by the Federal Drug Administration."9.12Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis. ( Chen, X; Feng, L; Qin, Y; Yang, L; Yao, H, 2021)
"The diagnosis of hypoglycemia and the use of diazoxide have risen in the last decade."7.96Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism. ( Brar, PC; Cossen, K; De Leon, DD; Heksch, R; Kamboj, MK; Marks, SD; Marshall, BA; Miller, R; Mitchell, D; Page, L; Stanley, T; Thornton, P, 2020)
"The aim of the study was to characterize factors that may serve as clinical tools to identify neonates with transient neonatal hyperinsulinism hypoglycemia (HH) who may benefit from diazoxide treatment."7.96Higher C-peptide levels and glucose requirements may identify neonates with transient hyperinsulinism hypoglycemia who will benefit from diazoxide treatment. ( Davidov, AS; Elkon-Tamir, E; Eyal, O; Haham, A; Lebenthal, Y; Mandel, D; Oren, A; Shefer, G; Weintrob, N, 2020)
"Diazoxide is first-line treatment for hyperinsulinaemic hypoglycaemia (HH) but diazoxide-induced pulmonary hypertension (PH) can occur."7.91Diazoxide-induced pulmonary hypertension in hyperinsulinaemic hypoglycaemia: Recommendations from a multicentre study in the United Kingdom. ( Aftab, S; Banerjee, I; Bath, L; Chen, SC; Christov, G; Dastamani, A; Giardini, A; Hunter, L; Pintus, D; Senniappan, S; Shah, P; Shaikh, MG; Swinburne, C; Yau, D, 2019)
" The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia."7.81Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide. ( Aso, Y; Hiraishi, H; Kojima, M; Shimizu, M; Suzuki, K; Tsuchida, K, 2015)
"Recessive mutations in the hydroxyacyl-CoA dehydrogenase (HADH) gene encoding the enzyme 3-hydroxyacyl-CoA dehydrogenase are a rare cause of diazoxide-responsive hyperinsulinemic hypoglycemia (HH) with just five probands reported to date."7.77Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees. ( Akcay, T; Alaei, M; Desai, M; Ellard, S; Flanagan, SE; Hussain, K; Kapoor, RR; Locke, JM; Patch, AM; Simsek, E; Yekta, Z, 2011)
"Diazoxide is the main therapeutic agent for persistent hyperinsulinemic hypoglycemia."7.77Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide. ( Arasli, A; Çetin, II; Demirel, F; Esen, I; Unal, S, 2011)
"The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY)."7.76Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. ( Akcay, T; Banerjee, I; Cody, D; Ellard, S; Flanagan, SE; Hussain, K; Kapoor, RR; Mali, G; Murphy, N; Rubio-Cabezas, O; Schwahn, B; Shield, JP; Siahanidou, T, 2010)
"Diazoxide is commonly used in the treatment of neonatal hyperinsulinism."7.74Development of pulmonary hypertension in an infant treated with diazoxide. ( Caldwell, RL; Eugster, EA; Hoover, WC; Nebesio, TD; Nitu, ME, 2007)
"The intraislet insulin hypothesis for the signaling of the glucagon secretory response to hypoglycemia states that a decrease in arterial glucose --> a decrease in beta-cell insulin secretion --> a decrease in tonic alpha-cell inhibition by insulin --> an increase in alpha-cell glucagon secretion."7.73Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans. ( Cryer, PE; Raju, B, 2005)
"The present report describes a mother and 2 children with leucine-induced hypoglycemia (LIH)."7.67Leucine-induced hypoglycemia in a family: effect of diphenylhydantoin, oxprenolol, and diazoxide. ( Colin, AA; Guttman, H; Hochberg, Z; Spindel, A, 1984)
"Diazoxide, as demonstrated by the case we present, may be of substantial value in abolishing hypoglycemia and in preventing its recurrence."7.66Management of chlorpropamide-induced hypoglycemia with diazoxide. ( Pfeifer, MA; Samols, E; Wolter, CF, 1978)
"Four children, treated with diazoxide for idiopathic leucine-sensitive (ILS) hypoglycemia of infancy, had follow-up studies at 2 to 10 yr of age to assess: (1) persistence of leucine sensitivity in later childhood."7.66Idiopathic leucine-sensitive hypoglycemia syndrome: insulin and glucagon responses and effects of diazoxide. ( Kogut, MD; Roe, TF, 1982)
"Two cases of hypertrichosis due to diazoxide are described."7.65Hypertrichosis due to diazoxide. ( Burton, JL; Caldwell, IW; Schutt, WH, 1975)
"Twelve patients with either severe preeclampsia (9) or eclampsia (3) were treated with intravenous diazoxide, 300-mg bolus, for the reduction of diastolic blood pressure (less than or equal 110 torr) after the usual and customary measures had been initiated to include parenteral MgSO4 and diazepam."7.65The management of severe preeclampsia and eclampsia with intravenous diazoxide. ( Arce, JJ; Bloom, RS; Clark, JH; Davidson, EC; Hamilton, CJ; Maidman, JE; Morris, JA, 1977)
" Glucose therapy alone was not sufficient to control the hypoglycemia, but the administration of glucose plus diazoxide raised the blood sugar to supranormal levels."7.65Chlorpropamide-induced hypoglycemia: successful treatment with diazoxide. ( Johnson, SF; Peake, GT; Schade, DS, 1977)
"Since 1969 leucine sensitive hypoglycemia has been diagnosed in 4 infants."7.65[Leucine sensitive hypoglycemia. Follow-up studies under treatment with diazoxide (author's transl)]. ( Lücking, T, 1976)
"Individuals with long-standing type 1 diabetes (T1D) are at increased risk of severe hypoglycemia secondary to impairments in normal glucose counterregulatory responses (CRRs)."6.80Diazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long-standing type 1 diabetes. ( George, PS; McCrimmon, RJ; Palmer, CN; Tavendale, R, 2015)
"Diazoxide was originally approved as an anti-hypertensive medication, but also is known to bind ATP-sensitive K channels in the beta cells of the pancreas, ultimately leading to inhibition of insulin release."5.56The use of diazoxide in the management of spontaneous hypoglycemia in patients with ESRD. ( Kristan, M; Lamos, EM; Malek, R; Mesmar, B; Munir, KM; Satyarengga, M, 2020)
"Diazoxide is a non-diuretic benzothiadiazine derivative, one of a group of substances introduced into clinical practice in the 1950s for the treatment of hypertension."5.43Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( Inoue, Y; Komatsu, Y; Miyoshi, H; Nakamura, A; Tajima, K; Takano, T; Takihata, M; Terauchi, Y; Tsuchiya, H; Yahagi, S; Yamakawa, T; Yoshida, M, 2016)
"Cardiorespiratory failure (toxicity) occurred on eight of the 11 occasions (73%) in seven infants."5.28Complications of diazoxide treatment in persistent neonatal hyperinsulinism. ( Abu-Osba, YK; Manasra, KB; Mathew, PM, 1989)
"Diazoxide (10 mg/kg/d) was successful in controlling hypoglycemia for eight years and one year, respectively, without serious side effects."5.27Persistent neonatal hyperinsulinemic hypoglycemia in two siblings successfully treated with diazoxide. ( Schubiger, G; Wüthrich, C; Zuppinger, K, 1986)
"Diazoxide is the first-line drug for treating hyperinsulinism and the only pharmacological agent approved for hyperinsulinism by the Federal Drug Administration."5.12Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis. ( Chen, X; Feng, L; Qin, Y; Yang, L; Yao, H, 2021)
" Medical control of the hormonal syndrome with agents such as diazoxide for insulinoma, omeprazole for gastrinoma, and octreotide for vipoma and glucagonoma allows an orderly and thorough investigation for associated endocrinopathies and comorbid medical conditions."4.79Islet cell tumors. ( Stabile, BE, 1997)
"Given that reports on severe diazoxide (DZX) toxicity are increasing, we aimed to understand if the short-term clinical outcomes of small-for-gestational-age (SGA) infants with hyperinsulinemic hypoglycemia (HH) managed primarily by supportive care, termed watchful waiting (WW), are different from those treated with DZX."4.31Watchful waiting versus pharmacological management of small-for-gestational-age infants with hyperinsulinemic hypoglycemia. ( Chandran, S; Chua, MC; Jaya-Bodestyne, SL; Rajadurai, VS; Saffari, SE; Yap, F, 2023)
"The diagnosis of hypoglycemia and the use of diazoxide have risen in the last decade."3.96Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism. ( Brar, PC; Cossen, K; De Leon, DD; Heksch, R; Kamboj, MK; Marks, SD; Marshall, BA; Miller, R; Mitchell, D; Page, L; Stanley, T; Thornton, P, 2020)
"The aim of the study was to characterize factors that may serve as clinical tools to identify neonates with transient neonatal hyperinsulinism hypoglycemia (HH) who may benefit from diazoxide treatment."3.96Higher C-peptide levels and glucose requirements may identify neonates with transient hyperinsulinism hypoglycemia who will benefit from diazoxide treatment. ( Davidov, AS; Elkon-Tamir, E; Eyal, O; Haham, A; Lebenthal, Y; Mandel, D; Oren, A; Shefer, G; Weintrob, N, 2020)
"Diazoxide is first-line treatment for hyperinsulinaemic hypoglycaemia (HH) but diazoxide-induced pulmonary hypertension (PH) can occur."3.91Diazoxide-induced pulmonary hypertension in hyperinsulinaemic hypoglycaemia: Recommendations from a multicentre study in the United Kingdom. ( Aftab, S; Banerjee, I; Bath, L; Chen, SC; Christov, G; Dastamani, A; Giardini, A; Hunter, L; Pintus, D; Senniappan, S; Shah, P; Shaikh, MG; Swinburne, C; Yau, D, 2019)
"Diazoxide is used to treat infants with persistent hypoglycemia, but the prevalence of its use and adverse effects are not well described."3.88Prevalence and safety of diazoxide in the neonatal intensive care unit. ( Benjamin, DK; Benjamin, R; Clark, RH; Cotten, CM; Dudash, K; Escobar, C; Freel, C; Gray, KD; Greenberg, RG; Harrison, T; McMillan, C; Puia-Dumitrescu, M, 2018)
" The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia."3.81Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide. ( Aso, Y; Hiraishi, H; Kojima, M; Shimizu, M; Suzuki, K; Tsuchida, K, 2015)
"This case series follows the evolving course of three patients with confirmed HNF4A-mediated congenital hyperinsulinism, highlighting (1) the variable natural history of these mutations, (2) the potential for prolonged diazoxide requirement, even into adolescence, and (3) the need for screening, regardless of family history."3.80The evolving course of HNF4A hyperinsulinaemic hypoglycaemia--a case series. ( Ellard, S; Flanagan, SE; Hawkes, CP; McDonnell, CM; McGlacken-Byrne, SM; Murphy, NP, 2014)
"The authors report a macrosomic term male infant who developed refractory hyperinsulinism requiring 20 mg/kg/min intravenous dextrose (usual range 4-6 mg/kg/min) and treatment with diazoxide 10 mg/kg/day."3.77Neonatal hyperinsulinism secondary to maternal intake of high-sugar drinks. ( Thorpe, M; West, NJ, 2011)
"Recessive mutations in the hydroxyacyl-CoA dehydrogenase (HADH) gene encoding the enzyme 3-hydroxyacyl-CoA dehydrogenase are a rare cause of diazoxide-responsive hyperinsulinemic hypoglycemia (HH) with just five probands reported to date."3.77Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees. ( Akcay, T; Alaei, M; Desai, M; Ellard, S; Flanagan, SE; Hussain, K; Kapoor, RR; Locke, JM; Patch, AM; Simsek, E; Yekta, Z, 2011)
"Diazoxide is the main therapeutic agent for persistent hyperinsulinemic hypoglycemia."3.77Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide. ( Arasli, A; Çetin, II; Demirel, F; Esen, I; Unal, S, 2011)
"The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY)."3.76Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. ( Akcay, T; Banerjee, I; Cody, D; Ellard, S; Flanagan, SE; Hussain, K; Kapoor, RR; Mali, G; Murphy, N; Rubio-Cabezas, O; Schwahn, B; Shield, JP; Siahanidou, T, 2010)
"Diazoxide is commonly used in the treatment of neonatal hyperinsulinism."3.74Development of pulmonary hypertension in an infant treated with diazoxide. ( Caldwell, RL; Eugster, EA; Hoover, WC; Nebesio, TD; Nitu, ME, 2007)
"We define a syndrome of prolonged neonatal hyperinsulinism that is responsive to diazoxide, persists for several months, and resolves spontaneously."3.73Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism. ( Hoe, FM; Simmons, RA; Stanley, CA; Steinkrauss, L; Thornton, PS; Wanner, LA, 2006)
"The intraislet insulin hypothesis for the signaling of the glucagon secretory response to hypoglycemia states that a decrease in arterial glucose --> a decrease in beta-cell insulin secretion --> a decrease in tonic alpha-cell inhibition by insulin --> an increase in alpha-cell glucagon secretion."3.73Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans. ( Cryer, PE; Raju, B, 2005)
" A mutation in the second nucleotide-binding fold (NBF2) of the sulfonylurea receptor (SUR) of an individual diagnosed with persistent hyperinsulinemic hypoglycemia of infancy generated KATP channels that could be opened by diazoxide but not in response to metabolic inhibition."3.69Adenosine diphosphate as an intracellular regulator of insulin secretion. ( Aguilar-Bryan, L; Bryan, J; Clement, JP; Glaser, B; Gonzalez, G; Nestorowicz, A; Nichols, CG; Permutt, MA; Shyng, SL, 1996)
" We describe a 72-year-old lady who initially presented with episodic hypoglycemia secondary to an insulinoma that was controlled by diazoxide."3.69Relapse of medically treated insulinoma following the development of thyrotoxicosis: an assessment of potential mechanisms. ( Alberti, KG; Kendall-Taylor, P; Trajano, LR; Walker, M, 1994)
"Serum concentrations of pancreatic glucagon were measured in 40 patients with hyperinsulinemic hypoglycemia."3.69Pancreatic glucagon levels in infants and children with hyperinsulinemia. ( Cedro, A; Gruszczyńska, B; Kamiński, W; Leśniewska, A; Pronicka, E; Woźniewicz, B, 1995)
" Following diagnosis of hyperinsulinemic hypoglycemia, this patient was treated with oral diazoxide."3.68Prenatal diagnosis of familial neonatal hyperinsulinemia. ( Aparicio, L; Carpenter, MW; Gruppuso, PA; Schwartz, R, 1993)
"The present report describes a mother and 2 children with leucine-induced hypoglycemia (LIH)."3.67Leucine-induced hypoglycemia in a family: effect of diphenylhydantoin, oxprenolol, and diazoxide. ( Colin, AA; Guttman, H; Hochberg, Z; Spindel, A, 1984)
"Hyperinsulinemic hypoglycemia secondary to nesidioblastosis persisted in a 4-year-old girl despite a 95% pancreatectomy and high-dose diazoxide treatment."3.66Persistent leucine sensitivity following partial pancreatectomy and diazoxide treatment. Therapeutic response. ( Bradvica, C; Golden, MP; Graham, MJ; Santiago, J; Sargeant, DT; White, NH; Zuniga, O, 1983)
"4 children with ketotic hypoglycemia (KH) showed during a fasting period over 24 hours significant higher decreases of serum alanine levels than normal controls."3.66[Pathogenesis of ketotic hypoglycemia (author's transl)]. ( Ploier, R; Sommer, R; Tulzer, W, 1979)
"Diazoxide, as demonstrated by the case we present, may be of substantial value in abolishing hypoglycemia and in preventing its recurrence."3.66Management of chlorpropamide-induced hypoglycemia with diazoxide. ( Pfeifer, MA; Samols, E; Wolter, CF, 1978)
"Four children, treated with diazoxide for idiopathic leucine-sensitive (ILS) hypoglycemia of infancy, had follow-up studies at 2 to 10 yr of age to assess: (1) persistence of leucine sensitivity in later childhood."3.66Idiopathic leucine-sensitive hypoglycemia syndrome: insulin and glucagon responses and effects of diazoxide. ( Kogut, MD; Roe, TF, 1982)
" The enzyme in the insulinomas, but not that in the nearby pancreases, was inhibited by diazoxide, which is a known inhibitor of insulin secretion in vitro and in vivo."3.66Increased mitochondrial glycerol phosphate dehydrogenase activity in insulinomas of two hypoglycemic infants. ( MacDonald, MJ; Pellett, JR; Warner, TF, 1983)
"Twelve patients with either severe preeclampsia (9) or eclampsia (3) were treated with intravenous diazoxide, 300-mg bolus, for the reduction of diastolic blood pressure (less than or equal 110 torr) after the usual and customary measures had been initiated to include parenteral MgSO4 and diazepam."3.65The management of severe preeclampsia and eclampsia with intravenous diazoxide. ( Arce, JJ; Bloom, RS; Clark, JH; Davidson, EC; Hamilton, CJ; Maidman, JE; Morris, JA, 1977)
" Glucose therapy alone was not sufficient to control the hypoglycemia, but the administration of glucose plus diazoxide raised the blood sugar to supranormal levels."3.65Chlorpropamide-induced hypoglycemia: successful treatment with diazoxide. ( Johnson, SF; Peake, GT; Schade, DS, 1977)
"In two children treated for hypoglycemia and convulsions with diazoxide and diphenylhydantoin, therapeutic serum diphenylhydantoin levels were not achieved despite doses of diphenylhydantoin of 17 and 29 mg/kg/day, respectively."3.65Drug interaction: diazoxide and diphenylhydantoin. ( Blaskovics, ME; Podosin, RL; Roe, TF, 1975)
"Two cases of hypertrichosis due to diazoxide are described."3.65Hypertrichosis due to diazoxide. ( Burton, JL; Caldwell, IW; Schutt, WH, 1975)
"Since 1969 leucine sensitive hypoglycemia has been diagnosed in 4 infants."3.65[Leucine sensitive hypoglycemia. Follow-up studies under treatment with diazoxide (author's transl)]. ( Lücking, T, 1976)
"Diazoxide is one such treatment that acts on the pancreatic β-cell in a dose-dependent manner to decrease insulin secretion."3.11Oral diazoxide versus placebo for severe or recurrent neonatal hypoglycaemia: Neonatal Glucose Care Optimisation (NeoGluCO) study - a randomised controlled trial. ( Alsweiler, JM; Ardern, J; Chase, JG; Cutfield, WS; Gamble, GD; Hanning, SM; Harding, JE; Laing, D; McKinlay, CJ; Meyer, MP; Rogers, J; Walsh, E, 2022)
"Individuals with long-standing type 1 diabetes (T1D) are at increased risk of severe hypoglycemia secondary to impairments in normal glucose counterregulatory responses (CRRs)."2.80Diazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long-standing type 1 diabetes. ( George, PS; McCrimmon, RJ; Palmer, CN; Tavendale, R, 2015)
"Diazoxide treatment reduced A1C from 8."2.75Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control. ( Dørflinger, GH; Grill, V; Hals, I; Kollind, M; Moen, T; Nermoen, I; Radtke, MA; Skeie, S; Svartberg, J; Sørheim, JI, 2010)
"Congenital hyperinsulinism is a genetic condition causing dysregulation of insulin and results in persistent hypoglycemia."2.50Congenital hyperinsulinism: exclusive human milk and breastfeeding. ( Edwards, TM; Spatz, DL, 2014)
"Neonatal hypoglycemia is one of the most common biochemical abnormalities encountered in the newborn."2.50Update on neonatal hypoglycemia. ( Rozance, PJ, 2014)
"Hyperinsulinism is a heterogeneous disorder characterised by severe hypoglycaemia due to an inappropriate oversecretion of insulin."2.41Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases. ( Bellane-Chantelot, C; Brunelle, F; Brusset, MC; Chigot, V; de Lonlay, P; Delagne, V; Fournet, JC; Groos, MS; Junien, C; Laborde, K; Martin, D; Mayaud, C; Nihoul-Fékété, C; Rahier, J; Robert, JJ; Saudubray, JM; Sempoux, C; Sevin, C; Touati, G; Vassault, A, 2002)
"Initial interventions for hyperinsulinemia are conservative."2.41When it is more than transient neonatal hypoglycemia: hyperinsulinemia--a case study challenge. ( Shirland, L, 2001)
"Diazoxide was commenced in 28 patients (82."1.72Clinical and genetic heterogeneity of HNF4A/HNF1A mutations in a multicentre paediatric cohort with hyperinsulinaemic hypoglycaemia. ( Brusgaard, K; Christesen, H; Conlon, N; Dastamani, A; Demirbilek, H; Flanagan, SE; Gubaeva, D; Houghton, JAL; McGlacken-Byrne, SM; Melikyan, M; Mohammad, JK; Murphy, NP; Schou, AJ; Shah, P; Siersbæk, J, 2022)
"Hyperinsulinism was permanent in two of these three cases."1.72Hyperinsulinism May Be Underreported in Hypoglycemic Patients with Phosphomannomutase 2 Deficiency ( Alikaşifoğlu, A; Dursun, A; Gönç, N; Ozon, A; Sivri, HS; Tokatlı, A; Vurallı, D; Yıldız, Y, 2022)
"Hypoglycemia was not repeated on endocrinological examination, even while fasting."1.72Diagnosis and Treatment Course of Insulinoma Presenting as Hypoglycemia Unawareness Using a Factory-Calibrated Continuous Glucose Monitoring System. ( Aida, A; Noto, H, 2022)
"This syndrome is characterised by recurrent episodes of hypoglycaemia and elevated ammonia levels, which are potentially harmful to both the patient and a developing fetus."1.56Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome. ( Bazelmans, M; Benner, BJM; Huidekoper, H; Langendonk, J; Langeveld, M; Schoenmakers, S, 2020)
"Transient hyperinsulinism are the most common cause of severe hypoglycemia in newborns."1.56[Transient hyperinsulinism in neonates]. ( Bockeria, EL; Bolmasova, AV; Degtyareva, AV; Ionov, OV; Krylova, NA; Melikyan, MA; Pekareva, NA; Ryumina, II, 2020)
"Diazoxide was originally approved as an anti-hypertensive medication, but also is known to bind ATP-sensitive K channels in the beta cells of the pancreas, ultimately leading to inhibition of insulin release."1.56The use of diazoxide in the management of spontaneous hypoglycemia in patients with ESRD. ( Kristan, M; Lamos, EM; Malek, R; Mesmar, B; Munir, KM; Satyarengga, M, 2020)
"BACKGROUND Hypoglycemia is rare in individuals without drug-treated diabetes mellitus."1.56Changing Insulinoma Management Due to Incidentally Discovered Metastasis: A Case Report. ( Chow, LS; Froelich, J; Madan, R; Mettler, T, 2020)
"Nesidioblastosis is a rare cause of adult hypoglycemia."1.51A Case Report of Insulinoma Relapse on Background Nesidioblastosis: A Rare Cause of Adult Hypoglycemia. ( Bonora, E; Castelli, C; Dauriz, M; Ferdeghini, M; Fuini, A; Landoni, L; Malleo, G; Maneschi, C; Moghetti, P; Tomezzoli, A, 2019)
"Diazoxide is a non-diuretic benzothiadiazine derivative, one of a group of substances introduced into clinical practice in the 1950s for the treatment of hypertension."1.43Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( Inoue, Y; Komatsu, Y; Miyoshi, H; Nakamura, A; Tajima, K; Takano, T; Takihata, M; Terauchi, Y; Tsuchiya, H; Yahagi, S; Yamakawa, T; Yoshida, M, 2016)
"Most cases of insulinomas are benign."1.43A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma. ( Berberabe, A; Pagsisihan, D; Palugod-Lopez, EG; Sandoval, MA, 2016)
"Hyperinsulinism was diagnosed as hypoglycemia concomitant with high serum insulin in babies requiring >6 mg/kg/min intravenous glucose and THI as hyperinsulinism without maternal diabetes or genetic disorders."1.42Fetal Erythroblastosis May Be an Indicator of Neonatal Transient Hyperinsulinism. ( Hata, D; Iki, Y; Katayama, T; Kawai, M; Mizumoto, H; Yamashita, S, 2015)
"Diazoxide is an effective and usually safe medication to treat this type and other types of neonatal HI."1.42Liver injury may increase the risk of diazoxide toxicity: a case report. ( Garibaldi, L; Mahmood, B; Sperling, M; Tas, E, 2015)
"Congenital hyperinsulinism is a condition of dysregulated insulin secretion often caused by inactivating mutations of the ATP-sensitive K+ (KATP) channel in the pancreatic beta cell."1.35Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations. ( Becker, S; Ganguly, A; Hanna, C; Lin, YW; MacMullen, C; Pinney, SE; Shyng, SL; Stanley, CA; Thornton, P, 2008)
"Insulinomas are rare neuroendocrine tumours that are usually small and may take time to localize."1.35Continuous glucose monitoring in patients with insulinoma. ( Choudhary, P; Harrison, B; Heller, S; Munir, A; Newell-Price, J, 2008)
"Hypoglycemia has been documented due to growth hormone and cortisol deficiency."1.33Costello syndrome and hyperinsulinemic hypoglycemia. ( Al-Sharkawi, I; Alexander, S; Alkhayyat, H; Backer, KC; El-Sabban, F; Hussain, K; Ramadan, D, 2005)
"Treatment with diazoxide and chlorthiazide is highly effective, appears to be safe, and does not need to be continued lifelong."1.33Hyperinsulinism in tyrosinaemia type I. ( Baumann, U; Green, A; Kelly, DA; McKiernan, PJ; Preece, MA, 2005)
"Diazoxide is an agonist of the pancreatic beta-cell KATP channel and inhibits insulin secretion."1.33Ketotic hypoglycaemia in children with diazoxide responsive hyperinsulinism of infancy. ( Hussain, K, 2005)
"Although insulinoma is rare in the elderly and exceedingly rare in the context of type 2 diabetes, it should be given due consideration when no other exacerbating factor is found."1.33A mysterious case of normalising blood sugar: insulinoma in a long-standing diabetic patient. ( Hameed, MF; Hoyle, GE; Muir, Z, 2006)
"A common and well recognised feature of Turner's syndrome (partial or total monosomy X) is impaired glucose tolerance or type 2 diabetes mellitus."1.33Mosaic Turner syndrome and hyperinsulinaemic hypoglycaemia. ( Alkhayyat, H; Brusgaard, K; Christesen, HB; Hussain, K; Steer, J; Stewart, H, 2006)
"Hyperinsulinism was diagnosed in our Clinic."1.31Neonatal hyperinsulinemic hypoglycemia. Two case reports. ( Antoniazzi, F; Maffeis, C; Tatò, L; Zaffanello, M; Zamboni, G, 2002)
"The hypoglycemia was refractory to high glucose delivery rates (25 mg/kg/min), but responded to a combination of octreotide and diazoxide."1.31Transient hyperinsulinism in an asphyxiated newborn infant with hypoglycemia. ( Clark, W; O'Donovan, D, 2001)
"Diazoxide was without effect on tau(open) and tau(closed,fast) but decreased significantly tau(closed,slow) (24."1.31Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells. ( Carlen, PL; Pahapill, PA; Pelletier, MR; Pennefather, PS, 2000)
"Hypoglycemia was induced with insulin and its effects on cerebral blood flow (measured with an electromagnetic flow transducer placed on the internal maxillary artery) were studied in awake goats under control conditions and after administration of the nitric oxide synthesis inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME, 47 mg/kg)."1.30Role of nitric oxide in the effects of hypoglycemia on the cerebral circulation in awake goats. ( Diéguez, G; Fernández, N; García, JL; García-Villalón, AL; Gomez, B; Monge, L, 1997)
"Diazoxide treatment remains the mainstay of medical therapy in long-term management."1.30Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: a retrospective review of 77 cases and analysis of efficacy-predicting criteria. ( Brunelle, F; Czernichow, P; Nihoul-Fekete, C; Ogier de Baulny, H; Poggi-Travert, F; Rahier, J; Saudubray, JM; Touati, G, 1998)
"When treatment with diazoxide and somatostatin for persistent hyperinsulinaemic hypoglycaemia of infancy failed, subtotal pancreatectomy was performed on a neonate on day 41."1.30Histochemical, clinical, and in vitro beta cell responses in a neonate with persistent hyperinsulinaemic hypoglycaemia of infancy. ( Hjelm, NM; Liew, CT; Panesar, NS; Poon, CW; Wong, GW, 1998)
"Treatment with diazoxide is rational and effective and may be lifesaving."1.28Clinical spectrum of sulfonylurea overdose and experience with diazoxide therapy. ( Meatherall, RC; Palatnick, W; Tenenbein, M, 1991)
"Cardiorespiratory failure (toxicity) occurred on eight of the 11 occasions (73%) in seven infants."1.28Complications of diazoxide treatment in persistent neonatal hyperinsulinism. ( Abu-Osba, YK; Manasra, KB; Mathew, PM, 1989)
"Diazoxide was useful in the treatment of three patients but many side-effects were observed."1.28Hyperinsulinism in infancy. ( Chow, OK; Low, LC; Yeung, CY; Young, RT; Yu, EC, 1989)
"Oral diazoxide was effective in reversing the marked hypoglycaemia."1.27Reversal of pentamidine-induced hypoglycaemia with oral diazoxide. ( Fitzgerald, DB; Young, IS, 1984)
"Diazoxide treatment could be stopped at the age of 1 month."1.27Transient lactic acidosis and hyperalaninaemia associated with neonatal hyperinsulinaemic hypoglycaemia: the effects of dichloroacetate (DCA). ( Aynsley-Green, A; Jenkins, PA; Soltész, G; Weindling, AM, 1983)
"Diazoxide (10 mg/kg/d) was successful in controlling hypoglycemia for eight years and one year, respectively, without serious side effects."1.27Persistent neonatal hyperinsulinemic hypoglycemia in two siblings successfully treated with diazoxide. ( Schubiger, G; Wüthrich, C; Zuppinger, K, 1986)
"The third has occasional fasting hypoglycemia that is treated with diazoxide; he continues to have a seizure disorder and is mentally retarded."1.26Nesidioblastosis in children. ( Danis, RK; Garvin, PJ; Knight, J; Lewis, JE; Willman, VL, 1980)
"To avoid mental retardation, surgical intervention should not be considered as a last resort."1.26Near-total pancreatectomy in persistent infantile hypoglycemia. ( Moazam, F; Rodgers, BM; Rosenbloom, AL; Talbert, JL, 1982)
"A seven months old infant suffered from convulsions due to leucine-sensitive hypoglycaemia."1.26[Leucine-sensitive hypoglycaemia and its treatment with diazoxide (author's transl)]. ( Reich, H; Schünke, W, 1976)
"Islet cell adenomas are an important consideration in infants and children with hypoglycemia due to hyperinsulinism."1.26Pancreatic adenomas in infants and children: current surgical management. ( Baker, L; Bishop, HC; Gauderer, M; Stanley, CA, 1978)
"In five patients with islet cell tumors and fasting hypoglycemia, basal proinsulin-like component ranged from 26 to 79% of the total immunoreactive insulin."1.25Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors. ( Gorden, P; Roth, J; Sherman, B, 1971)

Research

Studies (340)

TimeframeStudies, this research(%)All Research%
pre-1990199 (58.53)18.7374
1990's38 (11.18)18.2507
2000's39 (11.47)29.6817
2010's47 (13.82)24.3611
2020's17 (5.00)2.80

Authors

AuthorsStudies
McGlacken-Byrne, SM2
Mohammad, JK1
Conlon, N1
Gubaeva, D1
Siersbæk, J1
Schou, AJ1
Demirbilek, H1
Dastamani, A2
Houghton, JAL1
Brusgaard, K2
Melikyan, M1
Christesen, H1
Flanagan, SE6
Murphy, NP2
Shah, P3
Vurallı, D1
Yıldız, Y1
Ozon, A1
Dursun, A1
Gönç, N1
Tokatlı, A1
Sivri, HS1
Alikaşifoğlu, A1
Aida, A1
Noto, H1
Laing, D1
Walsh, E1
Alsweiler, JM1
Hanning, SM1
Meyer, MP1
Ardern, J1
Cutfield, WS1
Rogers, J1
Gamble, GD1
Chase, JG1
Harding, JE1
McKinlay, CJ1
Solís-García, G1
Yeung, T1
Jasani, B1
Chandran, S2
Jaya-Bodestyne, SL1
Rajadurai, VS2
Saffari, SE1
Chua, MC1
Yap, F1
Maines, E1
Urru, SAM1
Leonardi, L1
Fancellu, E1
Campomori, A1
Piccoli, G1
Maiorana, A1
Soffiati, M1
Franceschi, R1
Chen, SC1
Pintus, D1
Yau, D1
Aftab, S1
Bath, L1
Swinburne, C1
Hunter, L1
Giardini, A1
Christov, G1
Senniappan, S3
Banerjee, I4
Shaikh, MG1
Davidov, AS1
Elkon-Tamir, E1
Haham, A1
Shefer, G1
Weintrob, N1
Oren, A1
Lebenthal, Y1
Mandel, D1
Eyal, O1
Mesmar, B1
Kristan, M1
Satyarengga, M1
Lamos, EM1
Malek, R1
Munir, KM1
Shah, N1
Khadilkar, A1
Khadilkar, V1
Lad, S1
Madan, R1
Mettler, T1
Froelich, J1
Chow, LS1
Benner, BJM1
Bazelmans, M1
Huidekoper, H1
Langeveld, M1
Langendonk, J1
Schoenmakers, S1
Brar, PC1
Heksch, R1
Cossen, K1
De Leon, DD1
Kamboj, MK1
Marks, SD1
Marshall, BA1
Miller, R1
Page, L1
Stanley, T1
Mitchell, D1
Thornton, P3
Prado, LA1
Castro, M1
Weisz, DE1
Jain, A1
Belik, J1
Bolmasova, AV1
Melikyan, MA1
Krylova, NA1
Ionov, OV1
Ryumina, II1
Bockeria, EL1
Pekareva, NA1
Degtyareva, AV1
Chen, X1
Feng, L1
Yao, H1
Yang, L1
Qin, Y1
Nagaoka, M1
Akaishi, M1
Iida, K1
Yoshida, T1
Bourque, SL1
Rozance, PJ2
Hay, WW1
Veiguela Blanco, B1
Felechosa, MD1
García Moreira, V1
Reno, CM1
Bayles, J1
Skinner, A1
Fisher, SJ1
Gray, KD1
Dudash, K1
Escobar, C1
Freel, C1
Harrison, T1
McMillan, C1
Puia-Dumitrescu, M1
Cotten, CM1
Benjamin, R1
Clark, RH1
Benjamin, DK1
Greenberg, RG1
Salomon-Estebanez, M1
Nicholson, J1
Cosgrove, KE2
Dunne, MJ3
Welters, A1
Meissner, T1
Grulich-Henn, J1
Fröhlich-Reiterer, E1
Warncke, K1
Mohnike, K1
Blankenstein, O1
Menzel, U1
Datz, N1
Bollow, E1
Holl, RW1
Dauriz, M1
Maneschi, C1
Castelli, C1
Tomezzoli, A1
Fuini, A1
Landoni, L1
Malleo, G1
Ferdeghini, M1
Bonora, E1
Moghetti, P1
Vezzosi, D1
Guillaume, E1
Bennet, A1
Mouly, C1
Hanaire, H1
Caron, P1
Tabarin, A1
Goichot, B1
Hawkes, CP1
Ellard, S5
McDonnell, CM1
Martínez-Ortega, AJ1
Mangas-Cruz, MA1
Aliaga-Verdugo, A1
Acosta-Delgado, D1
Ponmani, C1
Gannon, H1
Hussain, K14
Chan, O4
Paranjape, SA2
Horblitt, A2
Zhu, W4
Sherwin, RS4
Ağladıoğlu, SY1
Savaş Erdeve, S1
Cetinkaya, S1
Baş, VN1
Peltek Kendirci, HN1
Onder, A1
Aycan, Z1
Hitman, GA1
Chong, JH1
Agarwal, P1
Edwards, TM1
Spatz, DL1
Vadász, J1
Barta, G1
Krasznai, G1
Ludger, F1
Zalatnai, A1
Manocha, D1
Shah, R1
Vaidya, GN1
Bansal, N1
George, PS1
Tavendale, R1
Palmer, CN1
McCrimmon, RJ2
Tas, E1
Mahmood, B1
Garibaldi, L1
Sperling, M1
Shimizu, M1
Suzuki, K1
Tsuchida, K1
Kojima, M1
Hiraishi, H1
Aso, Y1
Yoshioka, M1
Shibata, S1
Uchinami, H1
Watanabe, G1
Miyazawa, H1
Iida, M1
Yoshida, M2
Yoshioka, T1
Nanjo, H1
Yamamoto, Y1
Mizumoto, H1
Iki, Y1
Yamashita, S1
Kawai, M1
Katayama, T1
Hata, D1
Sadeghizadeh, A1
Hashemipour, M1
Hosseinzadeh, M1
Salehi, M1
Komatsu, Y1
Nakamura, A1
Takihata, M1
Inoue, Y1
Yahagi, S1
Tajima, K1
Tsuchiya, H1
Takano, T1
Yamakawa, T1
Miyoshi, H1
Terauchi, Y1
Sandoval, MA1
Pagsisihan, D1
Berberabe, A1
Palugod-Lopez, EG1
Shao, Y1
Qu, YQ1
Wang, XL1
Song, ZG1
Guo, QH1
Dou, JT1
Ba, JM1
Lü, ZH1
Mu, YM1
Pinney, SE1
MacMullen, C1
Becker, S1
Lin, YW1
Hanna, C1
Ganguly, A1
Shyng, SL3
Stanley, CA8
Narayanaswamy, V1
Rettig, KR1
Bhowmick, SK1
Spanakis, E1
Gragnoli, C1
Radtke, MA1
Nermoen, I1
Kollind, M1
Skeie, S1
Sørheim, JI1
Svartberg, J1
Hals, I1
Moen, T1
Dørflinger, GH1
Grill, V1
Vieira, TC1
Bergamin, CS1
Gurgel, LC1
Moisés, RS1
Kapoor, RR3
Mali, G1
Cody, D1
Murphy, N1
Schwahn, B1
Siahanidou, T1
Akcay, T2
Rubio-Cabezas, O1
Shield, JP2
Czyzyk, D1
Zhou, L1
Szabó, G1
Seashore, MR1
Dougherty, PP1
Klein-Schwartz, W1
Patch, AM1
Locke, JM1
Simsek, E1
Alaei, M1
Yekta, Z1
Desai, M1
Ross, JJ1
Vaidya, A1
Kaiser, UB1
Swaminathan, K1
Young, R1
Reid, W1
Demirel, F1
Unal, S1
Çetin, II1
Esen, I1
Arasli, A1
Levy, MJ1
Thompson, GB1
Topazian, MD1
Callstrom, MR1
Grant, CS1
Vella, A1
Thondam, SK1
Nair, S1
Wile, D1
Gill, GV1
West, NJ1
Thorpe, M1
Gomez Cruz, MJ1
Jabbar, M1
Saini, N1
Eng, D1
Crawford, B1
Vazquez, DM1
Menon, R1
Chen, M1
Avatapalle, B1
Malaiya, N1
Padidela, R1
Marics, G1
Amiel, J1
Vatai, B1
Lódi, C1
Mikos, B1
Tóth-Heyn, P1
Arya, VB1
Kumaran, A1
Zaffanello, M1
Zamboni, G1
Maffeis, C1
Antoniazzi, F1
Tatò, L1
Shirland, L1
Martinez-Ibanez, V1
Gussinyer, M1
Toran, N1
Lloret, J1
Abad, P1
Carrascosa, A1
Boix-Ochoa, J1
Sawathiparnich, P1
Likitmaskul, S1
Angsusingha, K1
Nimkarn, S1
Chaichanwatanakul, K1
Laohapansang, M1
Tuchinda, C1
Nagashima, K1
Shepherd, RM1
Chapman, JC1
Swift, SM1
Smith, VV1
Kassem, SA1
Glaser, B4
Lindley, KJ2
Aynsley-Green, A10
Semiz, S1
Bircan, I1
Akçurin, S1
Mihçi, E1
Melikoglu, M1
Karagüzel, G1
Kiliçaslan, B1
Karpuzoğlu, G1
Yoshikawa, H1
Honma, T1
Abe, T1
DRASH, A3
WOLFF, F4
LUNDVALL, O1
JOHNSSON, S1
ERNESTI, M2
MITCHELL, ML2
RABEN, MS2
GILBOA, Y1
Gonc, EN1
Turul, T1
Yordam, N1
Ersoy, F1
Thornton, PS3
Otonkoski, T1
Raju, B1
Cryer, PE1
Baumann, U1
Preece, MA1
Green, A1
Kelly, DA1
McKiernan, PJ1
Patti, ME1
McMahon, G1
Mun, EC1
Bitton, A1
Holst, JJ1
Goldsmith, J1
Hanto, DW1
Callery, M1
Arky, R1
Nose, V1
Bonner-Weir, S1
Goldfine, AB1
Rappaport, R2
Czernichow, P2
Giron, BJ1
Limal, JM1
Lenoir, G1
Hatemi, N1
Nihoul-Fekete, C6
Evans, ML1
Fan, X1
McNay, EC1
Ding, Y1
Gram, DX1
Alexander, S1
Ramadan, D1
Alkhayyat, H3
Al-Sharkawi, I1
Backer, KC1
El-Sabban, F1
Hoe, FM1
Wanner, LA1
Steinkrauss, L1
Simmons, RA1
Arao, T1
Okada, Y1
Hirose, A1
Tanaka, Y1
Hameed, MF1
Hoyle, GE1
Muir, Z1
Seppänen, M1
Näntö-Salonen, K1
Adzick, NS1
Minn, H1
Won, JG1
Tseng, HS1
Yang, AH1
Tang, KT1
Jap, TS1
Lee, CH1
Lin, HD1
Burcus, N1
Pittenger, G1
Vinik, A1
Fafoula, O1
Lawson, M1
Beverly, JL1
Christesen, HB1
Steer, J1
Stewart, H1
Nebesio, TD1
Hoover, WC1
Caldwell, RL1
Nitu, ME1
Eugster, EA1
Munir, A1
Choudhary, P1
Harrison, B1
Heller, S1
Newell-Price, J1
Combs, JT1
Grunt, JA1
Brandt, IK1
Ehrlich, R1
Martin, J1
Bain, HW1
Paraf, A2
Rautureau, J2
Texier, J1
Wright, J1
Abolfathi, A1
Penman, E1
Marks, V5
Hallengren, B1
Hökfelt, B1
Knight, J1
Garvin, PJ1
Danis, RK1
Lewis, JE1
Willman, VL1
Moazam, F1
Rodgers, BM1
Talbert, JL1
Rosenbloom, AL3
Berger, M1
Tsotsalas, M1
MacDonald, MJ1
Warner, TF1
Pellett, JR1
Soltész, G5
Fitzgerald, DB1
Young, IS1
Lyen, KR1
Jenkins, PA2
Hochberg, Z1
Spindel, A1
Guttman, H1
Colin, AA1
Kuroda, H1
Tsubota, T1
Hokaku, J1
Goshi, K1
Takahashi, T1
Weindling, AM1
Zuniga, O1
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Graham, MJ1
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Santucci, S1
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Pérez Carmona, NJ1
Balboa de Paz, F1
Maertens, P1
de Geeter, B1
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Justice, K1
Krentz, AJ1
Nagy, RJ1
Schade, DS2
Nichols, CG2
Nestorowicz, A2
Clement, JP1
Gonzalez, G1
Aguilar-Bryan, L1
Permutt, MA2
Bryan, J1
Elased, KM1
Playfair, JH1
Diéguez, G1
Fernández, N1
García, JL1
García-Villalón, AL1
Monge, L1
Gomez, B1
Stabile, BE1
Kane, C1
Johnson, PR1
James, RF1
Milla, PJ1
Yamada, Y1
Dacou-Voutetakis, C1
Psychou, F1
Maniati-Christidis, M1
Apak, RA1
Yurdakök, M1
Oran, O1
Senocak, ME1
Cağlar, M1
Ferrigni, T1
Shepard, JB1
Touati, G5
Poggi-Travert, F1
Ogier de Baulny, H1
Rahier, J4
Brunelle, F4
Saudubray, JM6
Panesar, NS1
Poon, CW1
Liew, CT1
Wong, GW1
Hjelm, NM1
de Lonlay-Debeney, P1
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Martin, D2
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Bergada, I1
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Orsini, JC1
Pelletier, MR1
Pahapill, PA1
Pennefather, PS1
Carlen, PL1
Konijnendijk, MA1
Zandbergen, AA1
Verheul, FE1
Baggen, MG1
Menni, F1
Sevin, C2
Peigné, C1
Barbier, V1
Clark, W1
O'Donovan, D1
Shaer, AJ1
Groos, MS1
Delagne, V1
Mayaud, C1
Chigot, V1
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Brusset, MC1
Laborde, K1
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Ambler, GR1
Yeow, WH1
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Silink, M1
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Floyd, JC2
Greenwood, RH1
Mahler, RF1
Hales, CN1
Uebersax, R1
Jeanmonod, D1
Meyrat, CA1
Berger, H1
Spahr, RC1
Habbick, BF1
Cram, RW1
Miller, KR1
Johnson, RK1
Jeschke, R1
Romen, W1
Thanner, F1
Niggemeyer, H1
Gauderer, M1
Bishop, HC2
Panizon, F1
Federspil, G3
Zaccaria, M1
De Palo, C1
Zago, E1
Erle, G1
Sicolo, N1
Scandellari, C1
Gardoni, L1
Giranzani, F1
Schikman, CH1
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Fariss, BL1
Tamburrano, G2
Tamburrano, S1
Natoli, C1
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Andreani, D2
Massi-Benedetti, F1
De Giorgi, G1
Baiocchi, E1
Vestri, F1
Carnevali, A1
Ploier, R1
Tulzer, W1
Sommer, R1
Pfeifer, MA1
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Samols, E3
Duvina, PL1
Jacobs, RF1
Nix, RA1
Paulus, TE1
Kiel, EA1
Fiser, RH1
Henningsen, L1
Johansen, K1
Crowder, WL1
Maclaren, NK1
Gutberlet, RL1
Frost, JL1
Mason, GR1
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Vigas, M1
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Fatranská, M1
Morris, JA1
Arce, JJ1
Hamilton, CJ1
Davidson, EC1
Maidman, JE1
Clark, JH1
Bloom, RS1
Moncrieff, MW1
Lacey, KA1
Malleson, PN1
Savage, JM1
Slattery, C1
Johnson, SF1
Peake, GT1
Petro, DJ1
Vannucci, RC1
Kulin, HE1
Reich, H1
Schünke, W1
S0vik, O1
Vidnes, J1
Falkmer, S1
Krämer, K1
Sailer, FX1
Podosin, RL1
Blaskovics, ME1
Kubimura, N1
Irieda, K1
Ito, J1
Konno, S1
Burton, JL1
Schutt, WH1
Caldwell, IW1
Lücking, T2
Antoine, MH1
Berkenboom, G1
Fang, ZY1
Fontaine, J1
Herchuelz, A1
Lebrun, P1
Davidson, DC1
Nunn, AJ1
Pears, J1
Jung, RT1
Browning, MC1
Taylor, R1
Burchell, A1
Gottschalk, ME1
Geffner, ME2
Yasuda, PM1
Shields, WD1
Takeda, H1
Watanabe, K1
Suzuki, D1
Miyano, R1
Tanaka, K1
Machimura, H1
Yagame, M1
Inoue, W1
Kaneshige, H1
Sakai, H1
Wales, JK2
Palatnick, W1
Meatherall, RC1
Tenenbein, M1
Meleo, K1
Parker, JJ1
Allen, DB1
Bjerke, HS1
Kelly, RE1
Fonkalsrud, EW1
Rousseau, C1
Willocx, D1
Bourlond, A1
Buts, JP1
Maes, M1
Lopez, A1
Abu-Osba, YK1
Manasra, KB1
Mathew, PM1
Low, LC1
Yu, EC1
Chow, OK1
Yeung, CY1
Young, RT1
Tchobroutsky, G4
Slama, G1
Chast, F1
Amendt, P1
Kohnert, KD1
Kunz, J1
Bahloul, F1
Goode, PN1
Farndon, JR1
Anderson, J1
Johnston, ID1
Morte, JA1
Mehta, A1
Wootton, R1
Cheng, KN1
Penfold, P1
Halliday, D1
Stacey, TE1
Prigent, F1
Gantzer, A1
Romain, O1
Massonaud, M1
Aufrant, C1
Bompard, Y1
Grant, DB2
Dunger, DB1
Burns, EC1
Sato, S1
Tsuzaki, S1
Matsuo, N1
Cho, H1
Nagai, T1
Tsuchiya, Y1
Wüthrich, C1
Schubiger, G1
Zuppinger, K1
Bell, WE1
Samaan, NA1
Longnecker, DS1
Wolff, G1
Croisier, JC1
Croisier, G1
Schaison, G1
Cassano, C1
Menzinger, G1
Fallucca, F1
Hunt, PS1
Grant, A2
Wales, J1
Viktora, J2
Yoshinaga, T2
Arnould, Y1
Ooms, HA1
Bastenie, PA1
Spergel, G1
Bleicher, SJ1
Linquette, M1
Fossati, P1
Decoulx, M1
Fourlinnie, JC1
Mariage, P1
Graber, AL2
Porte, D1
Williams, RH1
Hamilton, JP1
Kaye, R2
Koop, CE1
Mengoli, L1
Le Quesne, LP1
Salinas, ED1
Mangurten, HH1
Roberts, SS1
Simon, WH1
Shames, JM1
Dhurandhar, NR1
Blackard, WG1
Garces, LY1
Kenny, FM1
Etheridge, JE1
Thiffault, CA1
Knopf, RF1
Harrison, TS1
Conn, JW1
Kenny, F1
Field, J1
Blizzard, R1
Langs, H1
Steinke, J1
Soeldner, JS1
Scaliter, H1
Field, JB1
Boyle, C1
Remer, A1
Drapanas, T1
Wegienka, LC1
Simpson, RG1
Karam, JH1
Forsham, PH1
Vachon, A1
Noel, G1
Gauthier, J2
Tete, R1
Berthou, JD1
Fontaine, R1
Schneegans, E1
Haarscher, A1
Levy-Silagy, J1
Hasselmann, JL1
Dorner, M1
Assan, R4
Rosselin, G3
Kopf, A2
Dérot, M3
Welti, JJ1
Hanania, G1
Lambert, P1
Marteau, J1
Camillieri, JP1
Barbanel, C1
Vaysse, J1
Faye, C1
Aubert, P1
Tourneur, R1
Vieweg, WV1
Cerchio, GM1
Onoe, K1
Kobashi, K1
Fujinaka, S1
Yamamoto, T1
Hamajo, T1
Benabadji, A1
Loyau, G1
Kopp, J1
Sauvalle, A1
Porin, J1
Schwartz, JF1
Zwiren, GT1
Koch, G1
Gorden, P1
Sherman, B1
McGrath, WJ1
Balsam, MJ1
Hummeler, K1
Yakovac, WC1
Götz, M1
Rosenmayr, F1
Harrell, A1
Laurian, L1
Ayalon, D1
Kisch, E1
Cordova, T1
Kavlie, H1
White, TT1
Schein, PS1
Lefebvre, P2
Luyckx, A2
Cession-Fossion, A1
Pagliara, AS1
Karl, IE1
Haymond, M1
Kipnis, DM1
Patrassi, N2
Basoli, A2
Mineo, TC1
Carboni, M2
Castro, A1
Buist, NR1
Stefanini, P1
Grampa, G1
Gargantini, L1
Grigolato, PG1
Chiumello, G1
Saric, R1
Moreau, F1
Seguin, G1
Cohen, E1
Merlet, M1
Lorin, JC1
Tolloczko, T1
Wasiutyński, A1
Hunninghake, GW1
Higuchi, JH1
Kyner, JL1
Appleyard, WJ1
Lloyd, J1
Moreaux, J1
Hernandez, C1
Huguet, C1
Hepp, J1
Todt, H1
Mank, H1
Fang, P1
MacDonald, I1
Laver, M1
Hua, A1
Kincaid-Smith, P1
Schäfer, HJ1
Klöppel, G1
Schiff, D2
Colle, E1
Wells, D1
Stern, L1
Stern, C1
Gotlin, RW1
Gillissen, J1
Mirouze, J1
Jaffiol, C1
Mary, P1
Hansson, O1
Tuvemo, T1
Westphal, O1
Victorin, LH1
Thorell, JI1
Dutau, G1
Gire, JL1
Henry, M1
Rochiccioli, P1
Casara, D1
Stauffacher, W1
Black, J2
Isshiki, G1
Okuno, G1
Ueda, T1
Ogawa, S1
Hellman, B1
Idahl, LA1
Danielsson, A1
Loubatières, AL1
Brunetti, P1
Santeusanio, F1
Arena, D1
Palumbo, R1
Puxeddu, A1
De Ciuceis, P1
Calabrese, G1
Wüstenberg, PW1
Bower, BD1
Rayner, PH1
Stimmler, L1
Tevaarwerk, G1
Lowy, C1
Hartog, M1
Fraser, TR1
Radó, JP1
Szende, L1
Borbély, L1
Takó, J1
Beard, A1
Gentz, J1
Kellum, M1
Persson, B1
Zetterström, R1
Haworth, JC1
Fontaine, G1
Farriaux, JP1
Hongre, JF1
Trisotto, A1
Frezzato, S1
Green, OC1
Berger, S1
Goodman, HG1
Morishima, A1
Grumbach, MM1
Koblenzer, PJ2
Tucker, WR1
Ryan, WG1
Martin, BF1
Schwartz, TB1
Spechtmeyer, H1
Viktora, JK1
Wolff, FW1
Goldner, MG1
Spencer-Peet, J1
Norman, ME1
Lake, BD1
McNamara, J1
Patrick, AD1
Loubatières, A1
Mariani, MM1
Ribes, G1
Brown, RE1
Young, RB1
Ota, M1
Takeuchi, K1
Hibi, I1
Odawara, M1
Frerichs, H2
Willms, B1
Kasper, H1
Creutzfeldt, C2
Creutzfeldt, W2
Tamás, H1
László, K2
Royer, P1
Gabilan, JC1
Canet, J1
Bonnici, F1
Greenberg, RE1
Christiansen, RO1
Lopez, N1
Basabe, J1
Krees, S1
Terry, M1
Halmos, T1
Barthe, J1
Viala, JJ1
Loire, R1
Coeur, P1
Bizollon, C1
Croizat, P1
Laroche, C1
Grégoire, J1
Caquet, R1
Martin, JM1
Robb, GH1
Calesnick, B1
Katchen, B1
Javier, Z1
Gershberg, H1
Piesowicz, AT1
Buckler, JM1
Mereu, TR1
Kassoff, A1
Goodman, AD1
Fois, A1
Benedetti, PA1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Use of Diazoxide in Acute Hypoglycaemia[NCT01488136]Phase 412 participants (Actual)Interventional2012-01-31Completed
Use for Diazoxide in the Initial Management of Hypoglycemia in Infants of Diabetic Mothers and Infants Large for Gestation[NCT00994149]Phase 2/Phase 3100 participants (Anticipated)Interventional2009-10-31Not yet recruiting
Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery[NCT01841359]Phase 422 participants (Actual)Interventional2010-02-02Completed
A Prospective Randomized, Placebo (Saline)-Controlled, Balanced, 3-treatment Regimen Crossover Study Comparing the Effects of Prolonged (13 h) Hyperglucagonemia With Those of Acute (3 hr) Hyperglucagonemia on Energy Expenditure and Endogenous Glucose Prot[NCT02237053]Phase 16 participants (Actual)Interventional2014-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Continuous Glucose Monitoring Maximum Sensor Glucose Values Prior to (Baseline) and During Pramlintide Therapy.

(NCT01841359)
Timeframe: During 8 week period of participation, V1-V2 (baseline CGM data over 3 days); V3-V4 (CGM data during treatment with three times per day (TID) pramlintide over 3 days)

Interventionmg/dL (Mean)
Baseline (Prior to Treatment With Pramlintide) CGM #1172
Pramlintide CGM #2188

Continuous Glucose Monitoring Minimum Sensor Glucose Prior to (Baseline) and During Pramlintide Therapy.

(NCT01841359)
Timeframe: During 8 week period of participation, V1-V2 (baseline CGM data over 3 days); V3-V4 (CGM data during treatment with TID pramlintide over 3 days)

Interventionmg/dL (Mean)
Baseline (Prior to Treatment With Pramlintide) CGM #154
Pramlintide CGM #256.6

Dumping Score During Mixed Meal Testing at Baseline and During Treatment With Pramlintide

Dumping score was calculated using changes in pulse and hematocrit. Higher scores indicate more severe dumping. Scores ranged from -196 to 186. (NCT01841359)
Timeframe: Levels assessed on the two days of mixed meal testing: the first occurring at baseline; and the second following 8 weeks of treatment with pramlintide.

Interventiondumping score (Mean)
Baseline (Prior to Pramlintide Treatment) Mixed Meal #128.89
Pramlintide - Mixed Meal #272.04

Hypoglycemia - Percentage of Time Sensor Glucose Levels < 70 mg/dL Prior to (Baseline) and During Pramlintide Therapy.

Assessment of clinical response to pramlintide treatment, as indicated by paired comparison of the frequency of glucose values under 70 mg/dl (expressed as percentage of time) assessed by continuous glucose monitoring. (NCT01841359)
Timeframe: During 8 week period of participation, V1-V2 (baseline CGM data over 3 days); V3-V4 (CGM data during treatment with TID pramlintide over 3 days)

Interventionpercent time sensor glucose less than 70 (Mean)
Baseline (Prior to Treatment With Pramlintide) CGM #18.85
Pramlintide CGM #25.60

Nadir Plasma Glucose Levels During Mixed Meal Testing at Baseline and During Treatment With Pramlintide

(NCT01841359)
Timeframe: Levels assessed on the two days of mixed meal testing: the first occurring at baseline; and the second following 8 weeks of treatment with pramlintide.

Interventionmg/dL (Mean)
Baseline (Prior to Pramlintide Treatment) Mixed Meal #167.18
Pramlintide - Mixed Meal #269.9

Number of Days With Minimum Sensor Glucose < 54 mg/dL as Measured by Continuous Glucose Monitoring.

(NCT01841359)
Timeframe: During 8 week period of participation, V1-V2 (baseline CGM data over 3 days); V3-V4 (CGM data during treatment with TID pramlintide over 3 days)

Interventiondays (Mean)
Baseline (Prior to Treatment With Pramlintide) CGM #11.31
Pramlintide CGM #20.56

Number of Participants Requiring Rescue Treatment for Severe Hypoglycemia During Mixed Meal Testing (Visit 2 Baseline vs. Visit 4 Post-pramlintide Dosing)

(NCT01841359)
Timeframe: Assessed on the two days of mixed meal testing: the first occurring at baseline; and the second following 8 weeks of treatment with pramlintide.

Interventionnumber of participants (Number)
Baseline (Prior to Pramlintide Treatment) Mixed Meal #16
Pramlintide - Mixed Meal #24

Plasma Glucose Levels in Response to Mixed Meal Testing - Area Under the Curve for Plasma Glucose

"Baseline and post-treatment with pramlintide mixed meal testing plasma glucose values, area under the curve (AUC), calculated with the trapezoidal method.~Plasma glucose was measured at timepoints (minutes): -5 (baseline), 10 minutes, 20 minutes, 30 minutes, 60 minutes, 90 minutes, 120 minutes." (NCT01841359)
Timeframe: Levels assessed on the two days of mixed meal testing: the first occurring at baseline; and the second following 8 weeks of treatment with pramlintide.

Interventionmg*min/dL (Geometric Mean)
Baseline (Prior to Pramlintide Treatment) Mixed Meal #12828
Pramlintide - Mixed Meal #22893

Plasma Insulin Levels in Response to Mixed Meal Testing - Area Under the Curve for Plasma Insulin

"Pre- and post-treatment mixed meal testing plasma insulin levels area under the curve (AUC) was calculated with the trapezoidal method.~Plasma insulin was measured at timepoints (minutes): -5 (baseline), 10 minutes, 20 minutes, 30 minutes, 60 minutes, 90 minutes, 120 minutes." (NCT01841359)
Timeframe: Levels assessed on the two days of mixed meal testing: the first occurring at baseline; and the second following 8 weeks of treatment with pramlintide.

InterventionuIU*min/mL (Geometric Mean)
Baseline (Prior to Pramlintide Treatment) Mixed Meal #13393
Pramlintide - Mixed Meal #23501

Satiety Score During Mixed Meal Testing at 120 Minutes

Satiety was analyzed using a visual analogue scale (1, very hungry to 10, not hungry), administered 120 minutes following ingestion of mixed meal. (NCT01841359)
Timeframe: Levels assessed on the two days of mixed meal testing at the 120 min time point: the first occurring at baseline (prior to treatment with pramlintide), and the second following 8 weeks of treatment with pramlintide.

Interventionsatiety score (Mean)
Baseline (Prior to Pramlintide Treatment) Mixed Meal #14.57
Pramlintide - Mixed Meal #25.43

Time to Nadir Plasma Glucose During Mixed Meal Testing at Baseline and During Treatment With Pramlintide

(NCT01841359)
Timeframe: Assessed on the two days of mixed meal testing: the first occurring at baseline; and the second following 8 weeks of treatment with pramlintide.

Interventionminutes (Mean)
Baseline (Prior to Pramlintide Treatment) Mixed Meal #164.29
Pramlintide - Mixed Meal #266.43

Reviews

33 reviews available for diazoxide and Fasting Hypoglycemia

ArticleYear
Drug-induced hyperinsulinemic hypoglycemia: An update on pathophysiology and treatment.
    Reviews in endocrine & metabolic disorders, 2023, Volume: 24, Issue:6

    Topics: Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Insulin Secretion

2023
Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis.
    PloS one, 2021, Volume: 16, Issue:2

    Topics: Antihypertensive Agents; Diazoxide; Humans; Hyperinsulinism; Hypertrichosis; Hypoglycemia; Treatment

2021
Autoimmune hypoglycemia due to anti-insulin antibodies.
    Medicina clinica, 2018, 06-22, Volume: 150, Issue:12

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Autoimmune Dis

2018
Therapies and outcomes of congenital hyperinsulinism-induced hypoglycaemia.
    Diabetic medicine : a journal of the British Diabetic Association, 2019, Volume: 36, Issue:1

    Topics: Antihypertensive Agents; Congenital Hyperinsulinism; Diazoxide; Gastrointestinal Agents; Glucagon; H

2019
Update on neonatal hypoglycemia.
    Current opinion in endocrinology, diabetes, and obesity, 2014, Volume: 21, Issue:1

    Topics: Biosensing Techniques; Blood Glucose; Developmental Disabilities; Diazoxide; Diuretics; Female; Gluc

2014
Congenital hyperinsulinism: exclusive human milk and breastfeeding.
    Advances in neonatal care : official journal of the National Association of Neonatal Nurses, 2014, Volume: 14, Issue:4

    Topics: Breast Feeding; Congenital Hyperinsulinism; Diazoxide; Female; Fluid Therapy; Food, Fortified; Gastr

2014
Octreotide's role in the management of sulfonylurea-induced hypoglycemia.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2010, Volume: 6, Issue:2

    Topics: Animals; Diazoxide; Diuretics; Gastrointestinal Agents; Glucagon; Humans; Hypoglycemia; Hypoglycemic

2010
When it is more than transient neonatal hypoglycemia: hyperinsulinemia--a case study challenge.
    Neonatal network : NN, 2001, Volume: 20, Issue:4

    Topics: Blood Glucose; Brain Damage, Chronic; Diagnosis, Differential; Diazoxide; Enteral Nutrition; Female;

2001
[PHHI (persistent hyperinsulinemic hypoglycemia of infancy)].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 10

    Topics: Animals; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Diagnosis, Differential; Diazo

2002
Medications used in the treatment of hypoglycemia due to congenital hyperinsulinism of infancy (HI).
    Pediatric endocrinology reviews : PER, 2004, Volume: 2 Suppl 1

    Topics: Congenital Hyperinsulinism; Diazoxide; Gastrointestinal Agents; Glucagon; Humans; Hypoglycemia; Infa

2004
Hyperinsulinism in infancy and childhood.
    Ergebnisse der inneren Medizin und Kinderheilkunde, 1984, Volume: 51

    Topics: Beckwith-Wiedemann Syndrome; Blood Glucose; Child, Preschool; Diazoxide; Erythroblastosis, Fetal; Fe

1984
Hypoglycaemia in infancy and childhood.
    The Journal of the Singapore Paediatric Society, 1984, Volume: 26, Issue:1-2

    Topics: Blood Glucose; Child; Child, Preschool; Diazoxide; Fasting; Glycogen Storage Disease Type I; Humans;

1984
Islet cell tumors.
    The Gastroenterologist, 1997, Volume: 5, Issue:3

    Topics: Adenoma, Islet Cell; Diazoxide; Gastrinoma; Humans; Hypoglycemia; Insulinoma; Octreotide; Pancreatic

1997
[Persistent hyperinsulinemic hypoglycemia of infancy (PHHI)].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55 Suppl

    Topics: Adenosine Triphosphate; Diazoxide; Glycosyltransferases; GTP-Binding Proteins; Humans; Hyperinsulini

1997
Persistent hyperinsulinemic hypoglycemia of infancy: long-term results.
    Journal of pediatric endocrinology & metabolism : JPEM, 1998, Volume: 11 Suppl 1

    Topics: Adolescent; Adult; Child; Child, Preschool; Diazoxide; Dietary Proteins; Female; Hormones; Humans; H

1998
[Persistent hyperinsulinemic hypoglycemia in the newborn and infants].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1998, Volume: 5, Issue:12

    Topics: Diazoxide; Diuretics; Genetic Counseling; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, New

1998
Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases.
    European journal of pediatrics, 2002, Volume: 161, Issue:1

    Topics: Age of Onset; Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Genetic Heterogeneity; Gluc

2002
Persistent hyperinsulinaemic hypoglycaemia.
    Seminars in neonatology : SN, 2002, Volume: 7, Issue:1

    Topics: Diazoxide; Diuretics; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Pancreatectomy; Progno

2002
Diagnosis and medical management of insulinomas.
    Annual review of medicine, 1979, Volume: 30

    Topics: Adenoma, Islet Cell; Angiography; Antineoplastic Agents; Benzothiadiazines; Blood Glucose; C-Peptide

1979
[Juvenile endocrine hypoglycemia].
    Minerva medica, 1979, Jun-16, Volume: 70, Issue:28

    Topics: Adenoma; Child, Preschool; Diazoxide; Folic Acid; Fructose-1,6-Diphosphatase Deficiency; Gluconeogen

1979
[Hypoglycemia in childhood. Nosographic classification and diagnostic and therapeutic criteria].
    Recenti progressi in medicina, 1979, Volume: 66, Issue:6

    Topics: Diazoxide; Glucagon; Glucose; Humans; Hydrocortisone; Hypoglycemia; Infant; Infant, Newborn

1979
Hyperinsulinism in infants and children: diagnosis and therapy.
    Advances in pediatrics, 1976, Volume: 23

    Topics: Adult; Blood Glucose; Child; Child, Preschool; Diazoxide; Fatty Acids, Nonesterified; Humans; Hydrox

1976
Selected tests of carbohydrate metabolism.
    Clinics in endocrinology and metabolism, 1976, Volume: 5, Issue:3

    Topics: Adolescent; Adult; Blood Glucose; Carbohydrate Metabolism; Child; Clinical Laboratory Techniques; Di

1976
Management of insuloma patients with refractory hypoglycemia.
    Problems in veterinary medicine, 1990, Volume: 2, Issue:4

    Topics: Animals; Diazoxide; Dog Diseases; Dogs; Glucocorticoids; Hypoglycemia; Insulinoma; Prognosis; Somato

1990
The hepatic glycogenoses.
    Lancet (London, England), 1971, Jun-26, Volume: 1, Issue:7713

    Topics: Biopsy; Child; Chlorothiazide; Diazoxide; Female; Glucosidases; Glucosyltransferases; Glycogen Stora

1971
[Hypoglycemia. 3].
    Medizinische Monatsschrift, 1970, Volume: 24, Issue:7

    Topics: Animals; Arginine; Biguanides; Diazoxide; Dicumarol; Drug Synergism; Ethanol; Glucagon; Glucocortico

1970
Hypoglycemia and the central nervous system.
    Pediatric clinics of North America, 1967, Volume: 14, Issue:4

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Child, Preschool; Diazoxide; Diet Therapy; Epin

1967
[Hypoglycemia and its countermeasures].
    Nihon rinsho. Japanese journal of clinical medicine, 1969, Volume: 27, Issue:8

    Topics: Acute Disease; Adenoma, Islet Cell; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Animals; Bloo

1969
Chemotherapeutic management of the hormone-secreting endocrine malignancies.
    Cancer, 1972, Volume: 30, Issue:6

    Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Aminoglutethimide; Aniline Compounds; Antibiotics, Ant

1972
Hypoglycemia in infancy and childhood. II.
    The Journal of pediatrics, 1973, Volume: 82, Issue:4

    Topics: Adrenal Cortex Hormones; Adrenal Gland Diseases; Amino Acids; Carbohydrate Metabolism, Inborn Errors

1973
Diazoxide and the treatment of hypoglycemia: an historical review.
    Annals of the New York Academy of Sciences, 1968, Apr-11, Volume: 150, Issue:2

    Topics: Animals; Antihypertensive Agents; Diazoxide; Dogs; Drug Synergism; Glucose; Humans; Hyperglycemia; H

1968
[The hypoglycemia syndrome].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1970, Jun-01, Volume: 25, Issue:11

    Topics: Alloxan; Angiography; Antibiotics, Antineoplastic; Blood Glucose; Diagnosis, Differential; Diazoxide

1970
[Pharmacodynamical and clinical experimental studies of the treatment of hypoglycemia by diazoxide].
    La Presse medicale, 1967, Mar-25, Volume: 75, Issue:15

    Topics: Adult; Animals; Child; Diazoxide; Dogs; Humans; Hypoglycemia; Infant

1967

Trials

3 trials available for diazoxide and Fasting Hypoglycemia

ArticleYear
Oral diazoxide versus placebo for severe or recurrent neonatal hypoglycaemia: Neonatal Glucose Care Optimisation (NeoGluCO) study - a randomised controlled trial.
    BMJ open, 2022, 08-17, Volume: 12, Issue:8

    Topics: Blood Glucose; Diazoxide; Double-Blind Method; Female; Fetal Diseases; Glucose; Humans; Hypoglycemia

2022
Diazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long-standing type 1 diabetes.
    Diabetes, 2015, Volume: 64, Issue:6

    Topics: Adolescent; Adult; Diabetes Mellitus, Type 1; Diazoxide; Double-Blind Method; Female; Genotype; Huma

2015
Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control.
    Diabetes care, 2010, Volume: 33, Issue:3

    Topics: Adult; Antihypertensive Agents; Autoimmunity; Blood Glucose; Body Weight; Circadian Rhythm; Diabetes

2010

Other Studies

304 other studies available for diazoxide and Fasting Hypoglycemia

ArticleYear
Clinical and genetic heterogeneity of HNF4A/HNF1A mutations in a multicentre paediatric cohort with hyperinsulinaemic hypoglycaemia.
    European journal of endocrinology, 2022, Feb-22, Volume: 186, Issue:4

    Topics: Adolescent; Birth Weight; Child; Child, Preschool; Cohort Studies; Diabetes Mellitus, Type 1; Diabet

2022
Hyperinsulinism May Be Underreported in Hypoglycemic Patients with Phosphomannomutase 2 Deficiency
    Journal of clinical research in pediatric endocrinology, 2022, 08-25, Volume: 14, Issue:3

    Topics: Congenital Disorders of Glycosylation; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Hypoglycemi

2022
Diagnosis and Treatment Course of Insulinoma Presenting as Hypoglycemia Unawareness Using a Factory-Calibrated Continuous Glucose Monitoring System.
    The American journal of case reports, 2022, Jul-31, Volume: 23

    Topics: Adult; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Complications; Diazoxide; Humans; Hype

2022
Does the use of diazoxide for hyperinsulinaemic hypoglycaemia increase the risk of necrotising enterocolitis in neonates?
    Archives of disease in childhood, 2023, Volume: 108, Issue:9

    Topics: Diazoxide; Enterocolitis, Necrotizing; Female; Fetal Diseases; Humans; Hypoglycemia; Infant, Newborn

2023
Watchful waiting versus pharmacological management of small-for-gestational-age infants with hyperinsulinemic hypoglycemia.
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Awareness; Cognition; Diazoxide; Fasting; Humans; Hyperinsulinism; Hypoglycemia; Infant; Watchful Wa

2023
Diazoxide-induced pulmonary hypertension in hyperinsulinaemic hypoglycaemia: Recommendations from a multicentre study in the United Kingdom.
    Clinical endocrinology, 2019, Volume: 91, Issue:6

    Topics: Congenital Hyperinsulinism; Diazoxide; Echocardiography; Female; Gestational Age; Humans; Hypertensi

2019
Higher C-peptide levels and glucose requirements may identify neonates with transient hyperinsulinism hypoglycemia who will benefit from diazoxide treatment.
    European journal of pediatrics, 2020, Volume: 179, Issue:4

    Topics: Adult; Blood Glucose; C-Peptide; Case-Control Studies; Diazoxide; Female; Gestational Age; Humans; H

2020
The use of diazoxide in the management of spontaneous hypoglycemia in patients with ESRD.
    CEN case reports, 2020, Volume: 9, Issue:3

    Topics: Aged; Diazoxide; Female; Humans; Hypertension, Renal; Hypoglycemia; Kidney Failure, Chronic; Male; M

2020
Rare association of Beckwith-Wiedemann syndrome with Hirschsprung's disease in an infant with hypoglycemia.
    BMJ case reports, 2020, Apr-26, Volume: 13, Issue:4

    Topics: Beckwith-Wiedemann Syndrome; Combined Modality Therapy; Diazoxide; Female; Hirschsprung Disease; Hum

2020
Changing Insulinoma Management Due to Incidentally Discovered Metastasis: A Case Report.
    The American journal of case reports, 2020, Jun-14, Volume: 21

    Topics: Ablation Techniques; Bone Neoplasms; Diagnosis, Differential; Diazoxide; Endosonography; Female; Hum

2020
Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome.
    BMJ case reports, 2020, Aug-03, Volume: 13, Issue:8

    Topics: Adult; Diazoxide; Diet, Carbohydrate Loading; Directive Counseling; Female; Humans; Hyperammonemia;

2020
Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism.
    The Journal of clinical endocrinology and metabolism, 2020, 12-01, Volume: 105, Issue:12

    Topics: Child; Child, Preschool; Diazoxide; Disease Management; Female; Humans; Hyperinsulinism; Hypoglycemi

2020
Necrotising enterocolitis in newborns receiving diazoxide.
    Archives of disease in childhood. Fetal and neonatal edition, 2021, Volume: 106, Issue:3

    Topics: Canada; Correlation of Data; Diazoxide; Enterocolitis, Necrotizing; Female; Gastrointestinal Tract;

2021
[Transient hyperinsulinism in neonates].
    Problemy endokrinologii, 2020, 09-26, Volume: 66, Issue:4

    Topics: Diazoxide; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Insulin

2020
Diazoxide toxicity with hypoglycemia in infants with trisomy 13.
    Pediatrics and neonatology, 2021, Volume: 62, Issue:6

    Topics: Blood Glucose; Diazoxide; Humans; Hypoglycemia; Infant; Trisomy 13 Syndrome

2021
50 Years Ago in The Journal of Pediatrics: Diazoxide Treatment for Idiopathic Hypoglycemia of Infancy.
    The Journal of pediatrics, 2017, Volume: 189

    Topics: Blood Glucose; Diazoxide; Female; History, 20th Century; Humans; Hypoglycemia; Infant; Male; Pediatr

2017
Glibenclamide Prevents Hypoglycemia-Induced Fatal Cardiac Arrhythmias in Rats.
    Endocrinology, 2018, 07-01, Volume: 159, Issue:7

    Topics: Animals; Arrhythmias, Cardiac; Diazoxide; Glyburide; Heart Rate; Hypoglycemia; Insulin; Male; Random

2018
Prevalence and safety of diazoxide in the neonatal intensive care unit.
    Journal of perinatology : official journal of the California Perinatal Association, 2018, Volume: 38, Issue:11

    Topics: Diazoxide; Drug Utilization; Female; Gestational Age; Humans; Hypoglycemia; Infant, Newborn; Intensi

2018
Characterization of diabetes following pancreatic surgery in patients with congenital hyperinsulinism.
    Orphanet journal of rare diseases, 2018, 12-22, Volume: 13, Issue:1

    Topics: Adolescent; Blood Glucose; C-Peptide; Child; Child, Preschool; Congenital Hyperinsulinism; Diabetes

2018
A Case Report of Insulinoma Relapse on Background Nesidioblastosis: A Rare Cause of Adult Hypoglycemia.
    The Journal of clinical endocrinology and metabolism, 2019, 03-01, Volume: 104, Issue:3

    Topics: Diazoxide; Female; Humans; Hypoglycemia; Insulinoma; Middle Aged; Neoplasm Recurrence, Local; Nesidi

2019
Medical therapy in patients with endogenous hypoglycaemia: Is euglycaemia achievable?
    Clinical endocrinology, 2019, Volume: 90, Issue:6

    Topics: Adult; Aged; Blood Glucose; Blood Glucose Self-Monitoring; Diazoxide; Female; Glucocorticoids; Human

2019
Treatment: symptomatic treatment of hypoglycaemia.
    Annales d'endocrinologie, 2013, Volume: 74, Issue:3

    Topics: Antineoplastic Agents; Blood Glucose; Diazoxide; Everolimus; Humans; Hypoglycemia; Insulinoma; Octre

2013
The evolving course of HNF4A hyperinsulinaemic hypoglycaemia--a case series.
    Diabetic medicine : a journal of the British Diabetic Association, 2014, Volume: 31, Issue:1

    Topics: Age of Onset; Antihypertensive Agents; Birth Weight; Blood Glucose; Child; Child, Preschool; Congeni

2014
[Hirata's disease: report of a case].
    Medicina clinica, 2014, Feb-20, Volume: 142, Issue:4

    Topics: Aged, 80 and over; Asian People; Autoimmune Diseases; Diazoxide; Drug Substitution; Edema; HLA-D Ant

2014
Paradoxical hypoglycaemia associated with diazoxide therapy for hyperinsulinaemic hypoglycaemia.
    Hormone research in paediatrics, 2013, Volume: 80, Issue:2

    Topics: Congenital Hyperinsulinism; Diazoxide; Female; Glucagon; Glucose; Humans; Hypoglycemia; Infant; Octr

2013
Lactate-induced release of GABA in the ventromedial hypothalamus contributes to counterregulatory failure in recurrent hypoglycemia and diabetes.
    Diabetes, 2013, Volume: 62, Issue:12

    Topics: Animals; Bicuculline; Coumaric Acids; Diabetes Mellitus, Experimental; Diazoxide; GABA Antagonists;

2013
Hyperinsulinemic hypoglycemia: experience in a series of 17 cases.
    Journal of clinical research in pediatric endocrinology, 2013, Sep-10, Volume: 5, Issue:3

    Topics: Child; Child, Preschool; Developmental Disabilities; Diazoxide; Epilepsy; Female; Humans; Hyperinsul

2013
The variable faces of monogenic diabetes.
    Diabetic medicine : a journal of the British Diabetic Association, 2014, Volume: 31, Issue:1

    Topics: Antihypertensive Agents; Congenital Hyperinsulinism; Diazoxide; Female; Hepatocyte Nuclear Factor 4;

2014
Delayed presentation of prolonged hyperinsulinaemic hypoglycaemia in a preterm small-for-gestational age neonate.
    BMJ case reports, 2013, Dec-18, Volume: 2013

    Topics: Blood Glucose; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Infant, Sm

2013
[Insulin-like growth factor-II secreting prostate tumour causing severe hypoglycaemi].
    Orvosi hetilap, 2014, Aug-17, Volume: 155, Issue:33

    Topics: Adenocarcinoma; Aged, 80 and over; Diazoxide; Fatal Outcome; Glucose; Humans; Hypoglycemia; Immunohi

2014
Refractory hypoglycaemia in patient with gastric outlet obstruction.
    BMJ case reports, 2015, Jan-06, Volume: 2015

    Topics: Aged; Angiography; Diazoxide; Endosonography; Gastric Bypass; Gastric Outlet Obstruction; Glucose; H

2015
Liver injury may increase the risk of diazoxide toxicity: a case report.
    European journal of pediatrics, 2015, Volume: 174, Issue:3

    Topics: Albumins; Blood Glucose; Chemical and Drug Induced Liver Injury; Diazoxide; Heart Failure; Humans; H

2015
Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide.
    Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:6

    Topics: Antihypertensive Agents; Biomarkers, Tumor; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Dia

2015
The transformation of a nonfunctioning islet cell tumor of the pancreas into a proinsulinoma under conditions of lung metastasis.
    Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:7

    Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Is

2015
Fetal Erythroblastosis May Be an Indicator of Neonatal Transient Hyperinsulinism.
    Neonatology, 2015, Volume: 108, Issue:2

    Topics: Apgar Score; Birth Weight; Diazoxide; Erythroblastosis, Fetal; Erythrocyte Count; Female; Gestationa

2015
Genotype and phenotype correlations in Iranian patients with hyperinsulinaemic hypoglycaemia.
    BMC research notes, 2015, Aug-13, Volume: 8

    Topics: Cohort Studies; Cross-Sectional Studies; Diazoxide; DNA Mutational Analysis; Female; Gene Expression

2015
Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia.
    Endocrine journal, 2016, Volume: 63, Issue:3

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Diazoxide; Drug Monitoring; Drug Resistance; Edema

2016
A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma.
    BMJ case reports, 2016, Mar-18, Volume: 2016

    Topics: Biopsy; Blood Glucose; C-Peptide; Carcinoma, Neuroendocrine; Diazoxide; Humans; Hyperinsulinism; Hyp

2016
Malignant insulinoma: Report of 6 patients and literature review.
    Neuro endocrinology letters, 2016, Volume: 37, Issue:3

    Topics: Adult; Diazoxide; Diuretics; Female; Humans; Hypoglycemia; Insulinoma; Liver Neoplasms; Male; Middle

2016
Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations.
    The Journal of clinical investigation, 2008, Volume: 118, Issue:8

    Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Animals; ATP-Binding Cassette Transporters; C

2008
A lethargic neonate and an infant with seizure.
    Clinical pediatrics, 2010, Volume: 49, Issue:4

    Topics: Blood Glucose; Congenital Hyperinsulinism; Diazoxide; Glucagon; Glucose; Humans; Hypoglycemia; Infan

2010
Successful medical management of status post-Roux-en-Y-gastric-bypass hyperinsulinemic hypoglycemia.
    Obesity surgery, 2009, Volume: 19, Issue:9

    Topics: Antihypertensive Agents; Diazoxide; Female; Gastric Bypass; Humans; Hyperinsulinism; Hypoglycemia; M

2009
Hyperinsulinemic hypoglycemia evolving to gestational diabetes and diabetes mellitus in a family carrying the inactivating ABCC8 E1506K mutation.
    Pediatric diabetes, 2010, Volume: 11, Issue:7

    Topics: Adult; ATP-Binding Cassette Transporters; Child; Congenital Hyperinsulinism; Diabetes Mellitus; Diab

2010
Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations.
    European journal of endocrinology, 2010, Volume: 162, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Cohort Studies; Congenital Hyperinsulinism; Diazoxide; Female;

2010
Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia.
    American journal of physiology. Endocrinology and metabolism, 2010, Volume: 298, Issue:5

    Topics: Analysis of Variance; Animals; Bicuculline; Blood Glucose; Catheters, Indwelling; Diazoxide; Epineph

2010
Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees.
    The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:3

    Topics: 3-Hydroxyacyl CoA Dehydrogenases; Cohort Studies; Consanguinity; Diazoxide; Diuretics; Female; Genom

2011
Interactive medical case. Lying low.
    The New England journal of medicine, 2011, Feb-10, Volume: 364, Issue:6

    Topics: Aged, 80 and over; Confusion; Diazoxide; Dizziness; Female; Humans; Hypoglycemia; Insulinoma; Magnet

2011
The diagnosis was in her birthday party!
    QJM : monthly journal of the Association of Physicians, 2012, Volume: 105, Issue:5

    Topics: Aged, 80 and over; Blood Glucose; C-Peptide; Confusion; Diazoxide; Epilepsy, Tonic-Clonic; Female; H

2012
Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide.
    Journal of pediatric endocrinology & metabolism : JPEM, 2011, Volume: 24, Issue:7-8

    Topics: Diagnosis, Differential; Diazoxide; Ductus Arteriosus, Patent; Humans; Hyperinsulinism; Hypertension

2011
US-guided ethanol ablation of insulinomas: a new treatment option.
    Gastrointestinal endoscopy, 2012, Volume: 75, Issue:1

    Topics: Ablation Techniques; Adult; Aged; Aged, 80 and over; Blood Glucose; Diazoxide; Endosonography; Ethan

2012
Diazoxide for the treatment of hypoglycaemic dumping syndrome.
    QJM : monthly journal of the Association of Physicians, 2013, Volume: 106, Issue:9

    Topics: Aged; Aged, 80 and over; Diazoxide; Dumping Syndrome; Esophageal Achalasia; Female; Humans; Hypoglyc

2013
Neonatal hyperinsulinism secondary to maternal intake of high-sugar drinks.
    BMJ case reports, 2011, Jul-15, Volume: 2011

    Topics: Antihypertensive Agents; Carbonated Beverages; Diazoxide; Female; Glucose; Humans; Hyperinsulinism;

2011
Severe hypoglycemia secondary to methimazole-induced insulin autoimmune syndrome in a 16 year old African-American male.
    Pediatric diabetes, 2012, Volume: 13, Issue:8

    Topics: Adolescent; Antithyroid Agents; Autoantibodies; Autoimmune Diseases; Black or African American; Diaz

2012
Echocardiography monitoring for diazoxide induced pericardial effusion.
    BMJ case reports, 2012, Jul-03, Volume: 2012

    Topics: Administration, Oral; Child, Preschool; Diazoxide; Echocardiography; Humans; Hypoglycemia; Male; Mon

2012
Autonomic dysfunction of glucose homoeostasis in congenital central hypoventilation syndrome.
    Acta paediatrica (Oslo, Norway : 1992), 2013, Volume: 102, Issue:4

    Topics: Autoimmune Diseases; Cesarean Section; Diazoxide; Female; Homeodomain Proteins; Humans; Hypoglycemia

2013
Clinical and molecular characterisation of hyperinsulinaemic hypoglycaemia in infants born small-for-gestational age.
    Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:4

    Topics: Antihypertensive Agents; ATP-Binding Cassette Transporters; Blood Glucose; Diazoxide; Gestational Ag

2013
Neonatal hyperinsulinemic hypoglycemia. Two case reports.
    Minerva pediatrica, 2002, Volume: 54, Issue:4

    Topics: Asphyxia Neonatorum; Blood Glucose; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newbor

2002
Pancreatectomy extension in persistent hyperinsulinaemic hypoglycaemia: a new strategy.
    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 2002, Volume: 12, Issue:4

    Topics: Adenoma, Islet Cell; Algorithms; Child; Child, Preschool; Diazoxide; Humans; Hyperinsulinism; Hypogl

2002
Persistent hyperinsulinemic hypoglycemia of infancy: experience at Siriraj Hospital.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2002, Volume: 85 Suppl 2

    Topics: Blood Glucose; Diazoxide; Drug Therapy, Combination; Female; Glucagon; Glucose; Hospitals, Universit

2002
Uncontrolled insulin secretion from a childhood pancreatic beta-cell adenoma is not due to the functional loss of ATP-sensitive potassium channels.
    Endocrine-related cancer, 2002, Volume: 9, Issue:4

    Topics: Adenoma, Islet Cell; Adenosine Triphosphate; Antihypertensive Agents; Child; Chromosomes, Human, Pai

2002
Persistent hyperinsulinaemic hypoglycaemia of infancy: case report.
    East African medical journal, 2002, Volume: 79, Issue:10

    Topics: Anti-Inflammatory Agents; Blood Glucose; Consanguinity; Diazoxide; Epilepsy; Glucagon; Humans; Hyper

2002
Persistent hyperinsulinemic hypoglycaemia followed as benign infantile convulsion.
    Seizure, 2003, Volume: 12, Issue:3

    Topics: Diazoxide; Electroencephalography; Epilepsy, Benign Neonatal; Glucose; Humans; Hyperinsulinism; Hypo

2003
DRUG THERAPY IN LEUCINE-SENSITIVE HYPOGLYCEMIA.
    Metabolism: clinical and experimental, 1964, Volume: 13

    Topics: Antihypertensive Agents; Benzothiadiazines; Child; Diazoxide; Dietary Carbohydrates; Dietary Protein

1964
[INSULOMA TREATED WITH DIAZOXIDE].
    Nordisk medicin, 1965, Jan-21, Volume: 73

    Topics: Adenoma, Islet Cell; Antihypertensive Agents; Chlorthalidone; Diabetes Mellitus; Diazoxide; Geriatri

1965
CONTROL OF HYPOGLYCAEMIA WITH DIAZOXIDE AND HUMAN GROWTH HORMONE.
    Lancet (London, England), 1965, Mar-20, Volume: 1, Issue:7386

    Topics: Adenoma, Islet Cell; Antihypertensive Agents; Bendroflumethiazide; Blood Chemical Analysis; Blood Gl

1965
Hyperinsulinaemic hypoglycaemia in preterm neonates.
    Archives of disease in childhood. Fetal and neonatal edition, 2004, Volume: 89, Issue:1

    Topics: Birth Weight; Chlorothiazide; Diazoxide; Diuretics; Female; Glucose; Humans; Hyperinsulinism; Hypogl

2004
Trimethoprim-sulfamethoxazole induced prolonged hypoglycemia in an infant with MHC class II deficiency: diazoxide as a treatment option.
    Journal of pediatric endocrinology & metabolism : JPEM, 2003, Volume: 16, Issue:9

    Topics: Blood Glucose; C-Peptide; Diazoxide; Drug Administration Schedule; Female; Gene Expression; Genes, M

2003
Severe transient neonatal hyperinsulinism associated with hyperlactataemia in non-asphyxiated infants.
    Journal of pediatric endocrinology & metabolism : JPEM, 2004, Volume: 17, Issue:2

    Topics: Acidosis; Age of Onset; Blood Glucose; C-Peptide; Chlorothiazide; Diazoxide; Diuretics; Fasting; Fat

2004
Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans.
    Diabetes, 2005, Volume: 54, Issue:3

    Topics: Adult; Diazoxide; Female; Glucagon; Growth Hormone; Humans; Hydrocortisone; Hypoglycemia; Insulin; I

2005
Ketotic hypoglycaemia in children with diazoxide responsive hyperinsulinism of infancy.
    European journal of pediatrics, 2005, Volume: 164, Issue:6

    Topics: Congenital Hyperinsulinism; Diazoxide; Humans; Hypoglycemia; Infant, Newborn; Insulin Antagonists; K

2005
Hyperinsulinism in tyrosinaemia type I.
    Journal of inherited metabolic disease, 2005, Volume: 28, Issue:2

    Topics: Blood Glucose; C-Peptide; Chlorothiazide; Diazoxide; Diuretics; Humans; Hyperinsulinism; Hypoglycemi

2005
Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia.
    Diabetologia, 2005, Volume: 48, Issue:11

    Topics: Adult; Aged; Diazoxide; Diet Therapy; Dumping Syndrome; Female; Gastric Bypass; Humans; Hyperplasia;

2005
[Severe neonatal hypoglycemia due to pancreatic nesidioblastosis. Methods of diagnosis and treatment].
    Annales de pediatrie, 1977, Volume: 24, Issue:1

    Topics: Blood Glucose; Diagnosis, Differential; Diazoxide; Enteral Nutrition; Follow-Up Studies; Humans; Hyp

1977
Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats.
    Diabetes, 2005, Volume: 54, Issue:11

    Topics: Animals; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Carbonates; Cyclic S-Oxides; Diazox

2005
Costello syndrome and hyperinsulinemic hypoglycemia.
    American journal of medical genetics. Part A, 2005, Dec-15, Volume: 139, Issue:3

    Topics: Abnormalities, Multiple; Diazoxide; Fatal Outcome; Female; Humans; Hyperinsulinism; Hypoglycemia; In

2005
Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism.
    The Journal of pediatrics, 2006, Volume: 148, Issue:2

    Topics: Antihypertensive Agents; Calcium; Case-Control Studies; Diazoxide; Enteral Nutrition; Fasting; Femal

2006
A rare case of adult-onset nesidioblastosis treated successfully with diazoxide.
    Endocrine journal, 2006, Volume: 53, Issue:1

    Topics: Angiography; Blood Glucose; Diagnosis, Differential; Diazoxide; Humans; Hyperinsulinism; Hypoglycemi

2006
A mysterious case of normalising blood sugar: insulinoma in a long-standing diabetic patient.
    Age and ageing, 2006, Volume: 35, Issue:3

    Topics: Aged; Diabetes Mellitus, Type 2; Diazoxide; Female; Humans; Hypoglycemia; Insulinoma; Vasodilator Ag

2006
The diagnosis of ectopic focal hyperinsulinism of infancy with [18F]-dopa positron emission tomography.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:8

    Topics: Chlorothiazide; Cholecystectomy; Congenital Hyperinsulinism; Diazoxide; Fluorine Radioisotopes; Huma

2006
Clinical features and morphological characterization of 10 patients with noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS).
    Clinical endocrinology, 2006, Volume: 65, Issue:5

    Topics: Adult; Aged; Amyloid; Antigens, Neoplasm; Biomarkers; Biomarkers, Tumor; C-Peptide; Cell Proliferati

2006
Prolonged hyperinsulinaemic hypoglycaemia in newborns with intrauterine growth retardation.
    Archives of disease in childhood. Fetal and neonatal edition, 2006, Volume: 91, Issue:6

    Topics: Chlorothiazide; Diazoxide; Fetal Growth Retardation; Humans; Hyperinsulinism; Hypoglycemia; Hypoglyc

2006
ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia.
    Diabetes, 2007, Volume: 56, Issue:4

    Topics: Animals; Blood Glucose; Diazoxide; Epinephrine; gamma-Aminobutyric Acid; Glucagon; Glucose Clamp Tec

2007
Mosaic Turner syndrome and hyperinsulinaemic hypoglycaemia.
    Journal of pediatric endocrinology & metabolism : JPEM, 2006, Volume: 19, Issue:12

    Topics: Chromosome Aberrations; Chromosomes, Human, X; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglyce

2006
Development of pulmonary hypertension in an infant treated with diazoxide.
    Journal of pediatric endocrinology & metabolism : JPEM, 2007, Volume: 20, Issue:8

    Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hypertension, Pulmonary; Hypoglycemia; Hypoglycemic Agen

2007
Continuous glucose monitoring in patients with insulinoma.
    Clinical endocrinology, 2008, Volume: 68, Issue:6

    Topics: Adult; Aged; Antihypertensive Agents; Antineoplastic Agents, Hormonal; Blood Glucose; Diazoxide; Fem

2008
Hematologic reactions to diazoxide.
    Pediatrics, 1967, Volume: 40, Issue:1

    Topics: Adolescent; Agranulocytosis; Diazoxide; Female; Humans; Hypoglycemia; Infant; Thrombocytopenia

1967
Comment on management of hypoglycemia.
    The Journal of pediatrics, 1967, Volume: 71, Issue:4

    Topics: Diazoxide; Humans; Hypoglycemia; Leucine; Pancreatectomy

1967
[Hypoglycemia and primary cancer of the liver. Hormonal titers. Action of diazoxide].
    Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1967, Jan-27, Volume: 118, Issue:2

    Topics: Adult; Diazoxide; Glucagon; Growth Hormone; Humans; Hypoglycemia; Insulin; Liver Cirrhosis; Liver Ne

1967
Pancreatic somatostatinoma presenting with hypoglycaemia.
    Clinical endocrinology, 1980, Volume: 12, Issue:6

    Topics: Adenocarcinoma; Adult; Chlorothiazide; Diazoxide; Female; Fluorouracil; Humans; Hypoglycemia; Pancre

1980
Increase of serum androgens during diazoxide treatment.
    Lancet (London, England), 1984, Nov-03, Volume: 2, Issue:8410

    Topics: Adult; Androgens; Diazoxide; Female; Hirsutism; Humans; Hypoglycemia

1984
Nesidioblastosis in children.
    Archives of surgery (Chicago, Ill. : 1960), 1980, Volume: 115, Issue:7

    Topics: Adenoma, Islet Cell; Child, Preschool; Diazoxide; Female; Glucagon; Glucose; Humans; Hyperinsulinism

1980
Near-total pancreatectomy in persistent infantile hypoglycemia.
    Archives of surgery (Chicago, Ill. : 1960), 1982, Volume: 117, Issue:9

    Topics: Adenoma; Adenoma, Islet Cell; Diazoxide; Female; Humans; Hyperplasia; Hypoglycemia; Infant; Infant,

1982
[Therapy of hypoglycemia in the adult].
    Deutsche medizinische Wochenschrift (1946), 1983, Jul-08, Volume: 108, Issue:27

    Topics: Adenoma, Islet Cell; Adult; Diazoxide; Glucagon; Glucose; Humans; Hypoglycemia; Injections, Intraven

1983
Increased mitochondrial glycerol phosphate dehydrogenase activity in insulinomas of two hypoglycemic infants.
    The Journal of clinical endocrinology and metabolism, 1983, Volume: 57, Issue:3

    Topics: Adenoma, Islet Cell; Diazoxide; Female; Glycerolphosphate Dehydrogenase; Humans; Hypoglycemia; Infan

1983
Reversal of pentamidine-induced hypoglycaemia with oral diazoxide.
    The Journal of tropical medicine and hygiene, 1984, Volume: 87, Issue:1

    Topics: Adult; Amidines; Blood Glucose; Diazoxide; Humans; Hypoglycemia; Insulin; Male; Middle Aged; Pentami

1984
[Hypokalemia caused by hyperinsulinemia in infancy and childhood (based on 18 cases)].
    Orvosi hetilap, 1984, Jul-29, Volume: 125, Issue:31

    Topics: Blood Glucose; Child; Child, Preschool; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant; In

1984
Hyperinsulinaemic hypoglycaemia in infancy and childhood: a practical approach to diagnosis and medical treatment based on experience of 18 cases.
    Acta paediatrica Hungarica, 1984, Volume: 25, Issue:4

    Topics: Blood Glucose; Child; Diazoxide; Female; Glucose; Glucose Tolerance Test; Glycerol; Humans; Hyperins

1984
Leucine-induced hypoglycemia in a family: effect of diphenylhydantoin, oxprenolol, and diazoxide.
    Hormone research, 1984, Volume: 20, Issue:4

    Topics: Adult; Child; Child, Preschool; Diazoxide; Female; Genes, Dominant; Humans; Hypoglycemia; Infant; Le

1984
[Infant idiopathic hypoglycemia treated successfully with diazoxide].
    Horumon to rinsho. Clinical endocrinology, 1983, Volume: 31 Suppl

    Topics: Diazoxide; Humans; Hypoglycemia; Infant; Male

1983
Transient lactic acidosis and hyperalaninaemia associated with neonatal hyperinsulinaemic hypoglycaemia: the effects of dichloroacetate (DCA).
    European journal of pediatrics, 1983, Volume: 141, Issue:2

    Topics: Acetates; Acidosis; Alanine; Diazoxide; Dichloroacetic Acid; Humans; Hypoglycemia; Infant; Infant, N

1983
Persistent leucine sensitivity following partial pancreatectomy and diazoxide treatment. Therapeutic response.
    American journal of diseases of children (1960), 1983, Volume: 137, Issue:4

    Topics: Child, Preschool; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Leucine; Pancreatectomy;

1983
Efficacy of diazoxide in preventing hypoglycemia in a child affected by hypopituitary dwarfism.
    Acta paediatrica Scandinavica, 1983, Volume: 72, Issue:2

    Topics: Blood Glucose; Child, Preschool; Diazoxide; Dwarfism, Pituitary; Growth Hormone; Humans; Hypoglycemi

1983
Treatment of chlorpropamide overdose with diazoxide.
    Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:5

    Topics: Adolescent; Chlorpropamide; Diazoxide; Humans; Hypoglycemia; Male

1983
Hyperinsulinism.
    Acta paediatrica Academiae Scientiarum Hungaricae, 1980, Volume: 21, Issue:1

    Topics: Amino Acids, Branched-Chain; B-Lymphocytes; Blood Glucose; Child, Preschool; Diazoxide; Humans; Hype

1980
Nesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia.
    Archives of disease in childhood, 1981, Volume: 56, Issue:7

    Topics: Diazoxide; Female; Glucose; Humans; Hyperinsulinism; Hypoglycemia; In Vitro Techniques; Infant, Newb

1981
Increased 125I-insulin receptor binding to erythrocytes of hypoglycemic infants and children.
    Pediatric research, 1981, Volume: 15, Issue:10

    Topics: Adolescent; Adult; Blood Glucose; Child, Preschool; Diazoxide; Erythrocytes; Female; Glycogen Storag

1981
Idiopathic leucine-sensitive hypoglycemia syndrome: insulin and glucagon responses and effects of diazoxide.
    Pediatric research, 1982, Volume: 16, Issue:1

    Topics: Arginine; Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Glucagon; Humans; Hypoglycemia;

1982
[Long-term diazoxide therapy of the Beckwith-Wiedemann syndrome with persistent hypoglycemia].
    Minerva pediatrica, 1982, Sep-15, Volume: 34, Issue:17

    Topics: Beckwith-Wiedemann Syndrome; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant

1982
[Hyperinsulinism probably caused by diffuse pancreatic hyperplasia].
    Anales espanoles de pediatria, 1980, Volume: 13, Issue:11

    Topics: Child, Preschool; Diazoxide; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; Male; Pancreas; Psy

1980
[Long-term diazoxide therapy in recurrent leucine-sensitive hypoglycemia (author's transl)].
    Annales de pediatrie, 1980, Volume: 27, Issue:10

    Topics: Child, Preschool; Diazoxide; Female; Growth; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant,

1980
Treatment of drug-induced hypoglycemia.
    Annals of emergency medicine, 1980, Volume: 9, Issue:4

    Topics: Chlorpropamide; Diazoxide; Humans; Hypoglycemia

1980
Neonatal hypoglycemia.
    Current therapy in endocrinology and metabolism, 1994, Volume: 5

    Topics: Diazoxide; England; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn

1994
Paraneoplastic endocrine syndromes.
    Current therapy in endocrinology and metabolism, 1994, Volume: 5

    Topics: Acromegaly; Adrenocorticotropic Hormone; Aminoglutethimide; Bromocriptine; Calcitonin; Cushing Syndr

1994
Familial nesidioblastosis in two sisters.
    Surgery today, 1995, Volume: 25, Issue:2

    Topics: Adenoma, Islet Cell; Diazoxide; Fatal Outcome; Female; Humans; Hypoglycemia; Infant, Newborn; Pancre

1995
Pancreatic glucagon levels in infants and children with hyperinsulinemia.
    The Journal of pediatrics, 1995, Volume: 126, Issue:6

    Topics: Adolescent; Adult; Child; Child, Preschool; Diazoxide; Female; Glucagon; Humans; Hyperinsulinism; Hy

1995
Pre- and post-synaptic modulators of excitatory neurotransmission: comparative effects on hypoxia/hypoglycemia in cortical cultures.
    Brain research, 1994, Apr-18, Volume: 643, Issue:1-2

    Topics: Animals; Aspartic Acid; Benzopyrans; Calcium Channel Blockers; Cell Hypoxia; Cells, Cultured; Cerebr

1994
Relapse of medically treated insulinoma following the development of thyrotoxicosis: an assessment of potential mechanisms.
    Thyroid : official journal of the American Thyroid Association, 1994,Spring, Volume: 4, Issue:1

    Topics: Aged; C-Peptide; Diazoxide; Female; Humans; Hypoglycemia; Insulin; Insulin Resistance; Insulinoma; P

1994
K+ channel activators, acute glucose tolerance and glibenclamide-induced hypoglycaemia in the hypertensive rat.
    European journal of pharmacology, 1994, May-12, Volume: 257, Issue:1-2

    Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure;

1994
[Hyperinsulinemic hypoglycemia: a study of four cases].
    Anales espanoles de pediatria, 1993, Volume: 39, Issue:6

    Topics: Algorithms; Diazoxide; Female; Glucagon; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Insulin; Li

1993
Prenatal diagnosis of familial neonatal hyperinsulinemia.
    Acta paediatrica (Oslo, Norway : 1992), 1993, Volume: 82, Issue:8

    Topics: Administration, Oral; Amniotic Fluid; Blood Glucose; Diazoxide; Female; Fetal Blood; Glucose; Humans

1993
The enigma of persistent hyperinsulinemic hypoglycemia of infancy.
    The Journal of pediatrics, 1993, Volume: 123, Issue:4

    Topics: Diazoxide; Glucagon; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, Newborn; Octreo

1993
Short- and long-term use of octreotide in the treatment of congenital hyperinsulinism.
    The Journal of pediatrics, 1993, Volume: 123, Issue:4

    Topics: Diazoxide; Female; Follow-Up Studies; Glucagon; Glucose; Growth Disorders; Humans; Hyperinsulinism;

1993
Persistent hyperinsulinemic hypoglycemia of infancy: long-term octreotide treatment without pancreatectomy.
    The Journal of pediatrics, 1993, Volume: 123, Issue:4

    Topics: Diazoxide; Female; Follow-Up Studies; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Male;

1993
Octreotide reverses hyperinsulinemia and prevents hypoglycemia induced by sulfonylurea overdoses.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:3

    Topics: Adult; Blood Glucose; Diazoxide; Drug Overdose; Female; Glucose; Humans; Hyperinsulinism; Hypoglycem

1993
Adenosine diphosphate as an intracellular regulator of insulin secretion.
    Science (New York, N.Y.), 1996, Jun-21, Volume: 272, Issue:5269

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Tr

1996
Reversal of hypoglycaemia in murine malaria by drugs that inhibit insulin secretion.
    Parasitology, 1996, Volume: 112 ( Pt 6)

    Topics: Animals; Antimalarials; Blood Glucose; Diazoxide; Epinephrine; Hyperinsulinism; Hypoglycemia; Insuli

1996
Role of nitric oxide in the effects of hypoglycemia on the cerebral circulation in awake goats.
    European journal of pharmacology, 1997, Jul-09, Volume: 330, Issue:2-3

    Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Cerebrovascular Circulation; Diazoxide; Drug Inter

1997
Therapy for persistent hyperinsulinemic hypoglycemia of infancy. Understanding the responsiveness of beta cells to diazoxide and somatostatin.
    The Journal of clinical investigation, 1997, Oct-01, Volume: 100, Issue:7

    Topics: Blood Glucose; Cell Membrane; Diazoxide; Disease Management; Electrophysiology; Glycosyltransferases

1997
Preoperative use of octreotide in a newborn with persistent hyperinsulinemic hypoglycemia of infancy.
    Journal of pediatric endocrinology & metabolism : JPEM, 1998, Volume: 11 Suppl 1

    Topics: Diazoxide; Female; Glucose; Hormones; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Octreo

1998
Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy.
    Diabetes, 1998, Volume: 47, Issue:7

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alleles; Animals; ATP-Binding Cassette Transporters;

1998
Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: a retrospective review of 77 cases and analysis of efficacy-predicting criteria.
    European journal of pediatrics, 1998, Volume: 157, Issue:8

    Topics: Diazoxide; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hyperinsu

1998
Histochemical, clinical, and in vitro beta cell responses in a neonate with persistent hyperinsulinaemic hypoglycaemia of infancy.
    Archives of disease in childhood. Fetal and neonatal edition, 1998, Volume: 79, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Diazoxide; Diuretics; Glucose; Humans; Hyperinsulinism

1998
Loss of imprinted genes and paternal SUR1 mutations lead to hyperinsulinism in focal adenomatous hyperplasia.
    Annales d'endocrinologie, 1998, Volume: 59, Issue:6

    Topics: Adenoma, Islet Cell; ATP-Binding Cassette Transporters; Chromosomes, Human, Pair 11; Diazoxide; Drug

1998
Long-term follow up of persistent hyperinsulinaemic hypoglycaemia of infancy.
    Archives of disease in childhood, 1998, Volume: 79, Issue:5

    Topics: Diazoxide; Electroencephalography; Female; Follow-Up Studies; Head; Humans; Hyperinsulinism; Hypogly

1998
Management of sulfonylurea ingestions.
    Pediatric emergency care, 1999, Volume: 15, Issue:3

    Topics: Antidotes; Child; Diabetes Mellitus, Type 2; Diazoxide; Gastrointestinal Agents; Glucose; Humans; Hy

1999
Involvement of adenosine triphosphate-sensitive K+ channels in glucose-sensing in the rat solitary tract nucleus.
    Neuroscience letters, 2000, Jan-07, Volume: 278, Issue:1-2

    Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diazoxide; Glyburide; Homeostasis; Hypoglycemia; Hyp

2000
Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells.
    Journal of neurophysiology, 2000, Volume: 84, Issue:5

    Topics: Animals; Antihypertensive Agents; Dentate Gyrus; Diazoxide; Glyburide; Hypoglycemia; Hypoglycemic Ag

2000
Insulin autoimmune syndrome: the second Dutch case.
    The Netherlands journal of medicine, 2001, Volume: 58, Issue:1

    Topics: Aged; Aged, 80 and over; Autoimmune Diseases; Blood Glucose; Diazoxide; Follow-Up Studies; Humans; H

2001
Neurologic outcomes of 90 neonates and infants with persistent hyperinsulinemic hypoglycemia.
    Pediatrics, 2001, Volume: 107, Issue:3

    Topics: Age of Onset; Child; Child, Preschool; Developmental Disabilities; Diazoxide; Epilepsy; Humans; Hype

2001
Transient hyperinsulinism in an asphyxiated newborn infant with hypoglycemia.
    American journal of perinatology, 2001, Volume: 18, Issue:4

    Topics: Asphyxia Neonatorum; Blood Glucose; Diazoxide; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Infan

2001
Management of hyperinsulinemia with diazoxide in an elderly hemodialysis patient.
    Nephron, 2001, Volume: 89, Issue:3

    Topics: Aged; Aged, 80 and over; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Insulinoma; Nutrition Dis

2001
Ten years' experience of persistent hyperinsulinaemic hypoglycaemia of infancy.
    Journal of paediatrics and child health, 2001, Volume: 37, Issue:5

    Topics: Adolescent; Blood Glucose; Chi-Square Distribution; Child; Child Development; Child, Preschool; Diaz

2001
Diazoxide, glipizide, and hypoglycaemia.
    Lancet (London, England), 1977, Feb-05, Volume: 1, Issue:8006

    Topics: Blood Glucose; Diabetes Mellitus; Diazoxide; Drug Antagonism; Glipizide; Humans; Hypoglycemia; Insul

1977
[Hypoglycaemia (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1976, Apr-27, Volume: 65, Issue:17

    Topics: Alcoholism; Diazoxide; Endocrine System Diseases; Enzymes; Glucose; Humans; Hydrocortisone; Hypoglyc

1976
Hypoglycemia: a perspective.
    Postgraduate medicine, 1975, Volume: 57, Issue:2

    Topics: Adenoma, Islet Cell; Citric Acid Cycle; Diabetes Complications; Diazoxide; Female; Glucose; Glucose

1975
Von Gierke's disease: a review.
    Southern medical journal, 1976, Volume: 69, Issue:8

    Topics: Allopurinol; Bicarbonates; Blood Glucose; Diazoxide; Gluconeogenesis; Glucose-6-Phosphatase; Glycoge

1976
Neonatal hypoglycemia resulting from islet cell adenomatosis. Successful treatment with total pancreatectomy.
    American journal of diseases of children (1960), 1977, Volume: 131, Issue:2

    Topics: Adenoma, Islet Cell; Cortisone; Diazoxide; Female; Glucose; Humans; Hypoglycemia; Infant, Newborn; I

1977
Insulinoma in the dog.
    The Veterinary clinics of North America, 1977, Volume: 7, Issue:3

    Topics: Adenoma, Islet Cell; Animals; Diazoxide; Dog Diseases; Dogs; Glucagon; Hypoglycemia; Insulin; Pancre

1977
[The disease pattern of the diffuse, nesidioblastic hyperplasia of the pancreatic islets in newborn and infants (author's transl)].
    Klinische Padiatrie, 1978, Volume: 190, Issue:4

    Topics: Adenoma, Islet Cell; Diazoxide; Fatty Acids, Nonesterified; Humans; Hydroxybutyrates; Hypoglycemia;

1978
Pancreatic adenomas in infants and children: current surgical management.
    Journal of pediatric surgery, 1978, Volume: 13, Issue:6D

    Topics: Adenoma, Islet Cell; Child; Child, Preschool; Diazoxide; Follow-Up Studies; Humans; Hyperinsulinism;

1978
[Medical treatment of spontaneous hypoglycemic syndromes].
    Minerva medica, 1979, Jun-16, Volume: 70, Issue:28

    Topics: Adenoma, Islet Cell; Chlorpromazine; Diazoxide; Fasting; Glucagon; Glucose; Humans; Hypoglycemia; Li

1979
[Description of a case of type I glycogenosis treated with diazoxide].
    Minerva pediatrica, 1978, Oct-15, Volume: 30, Issue:19

    Topics: Diazoxide; Glycogen Storage Disease Type I; Humans; Hypoglycemia; Infant; Liver; Male; Seizures

1978
Paradoxical enhancement of tolbutamide-induced insulin release by diazoxide in a patient with islet cell hyperplasia.
    Acta paediatrica Scandinavica, 1978, Volume: 67, Issue:5

    Topics: Blood Glucose; Child; Diazoxide; Glucagon; Glucose Tolerance Test; Humans; Hyperplasia; Hypoglycemia

1978
Gastric carcinoma associated with severe hypoglycemia sensitive to diazoxide.
    Diabete & metabolisme, 1979, Volume: 5, Issue:4

    Topics: Adenocarcinoma; Aged; Blood Glucose; Diazoxide; Glucose Tolerance Test; Humans; Hypoglycemia; Insuli

1979
[Pathogenesis of ketotic hypoglycemia (author's transl)].
    Padiatrie und Padologie, 1979, Volume: 14, Issue:1

    Topics: Acidosis; Alanine; Child; Child, Preschool; Deoxyglucose; Diazoxide; Epinephrine; Fasting; Female; H

1979
Management of chlorpropamide-induced hypoglycemia with diazoxide.
    Southern medical journal, 1978, Volume: 71, Issue:5

    Topics: Aged; Chlorpropamide; Diazoxide; Humans; Hypoglycemia; Male

1978
[9 years of diazoxide therapy in a case of infantile idiopathic hypolglycemia].
    Minerva pediatrica, 1978, Aug-31, Volume: 30, Issue:16

    Topics: Child; Diazoxide; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Male; Prediabetic State; Se

1978
Intravenous infusion of diazoxide in the treatment of chlorpropamide-induced hypoglycemia.
    The Journal of pediatrics, 1978, Volume: 93, Issue:5

    Topics: Child; Chlorpropamide; Diazoxide; Humans; Hypoglycemia; Infusions, Parenteral; Male

1978
Oral diazoxide for hypoglycemia.
    The Medical letter on drugs and therapeutics, 1978, Dec-15, Volume: 20, Issue:25

    Topics: Administration, Oral; Animals; Diazoxide; Female; Humans; Hypoglycemia; Infant; Pregnancy

1978
Growth hormone secretion and diazoxide induced hyperglycaemia.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1978, Volume: 10, Issue:6

    Topics: Adult; Blood Glucose; Diazoxide; Growth Hormone; Humans; Hyperglycemia; Hypoglycemia; Male

1978
Neonatal pancreatic beta-cell hyperplasia: report of a case with failure of diazoxide and benefit of early subtotal pancreatectomy.
    Pediatrics, 1976, Volume: 57, Issue:6

    Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; Infant, Newborn; Infant, Newb

1976
[A case of idiopathic ketotic hypoglycemia successfully treated with diazoxid. (author's transl)].
    Bratislavske lekarske listy, 1977, Volume: 67, Issue:4

    Topics: Acidosis; Child, Preschool; Diazoxide; Female; Humans; Hypoglycemia; Ketosis

1977
The management of severe preeclampsia and eclampsia with intravenous diazoxide.
    Obstetrics and gynecology, 1977, Volume: 49, Issue:6

    Topics: Adolescent; Adult; Cesarean Section; Diazoxide; Eclampsia; Female; Humans; Hypertension; Hypoglycemi

1977
Management of prolonged hypoglycaemia in Beckwith's syndrome.
    Postgraduate medical journal, 1977, Volume: 53, Issue:617

    Topics: Abnormalities, Multiple; Adrenal Cortex Hormones; Diazoxide; Hernia, Umbilical; Humans; Hypoglycemia

1977
Hyperosmolar non-ketotic hyperglycaemia during oral diazoxide therapy of prolonged hyperglycaemia in infancy.
    The Ulster medical journal, 1977, Volume: 46, Issue:2

    Topics: Age Factors; Diabetic Coma; Diazoxide; Humans; Hyperglycemic Hyperosmolar Nonketotic Coma; Hyperinsu

1977
Chlorpropamide-induced hypoglycemia: successful treatment with diazoxide.
    The American journal of medicine, 1977, Volume: 63, Issue:5

    Topics: Adolescent; Chlorpropamide; Diazoxide; Glucagon; Glucose; Humans; Hypoglycemia; Insulin; Male

1977
Letter: Diazoxide-diphenylhydantoin interaction.
    The Journal of pediatrics, 1976, Volume: 89, Issue:2

    Topics: Child, Preschool; Diazoxide; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Hypogly

1976
[Leucine-sensitive hypoglycaemia and its treatment with diazoxide (author's transl)].
    Monatsschrift fur Kinderheilkunde, 1976, Volume: 129, Issue:9

    Topics: Amino Acid Metabolism, Inborn Errors; Blood Glucose; Diazoxide; Dietary Proteins; Female; Humans; Hy

1976
Persistent neonatal hypoglycaemia. A clinical and histopathological study of three cases treated with diazoxide and subtotal pancreatectomy.
    Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1975, Volume: 83, Issue:1

    Topics: Biopsy; Birth Weight; Blood Glucose; Diazoxide; Female; Follow-Up Studies; Glucose Tolerance Test; H

1975
[Diagnosis of organic hyperinsulinism].
    Anasthesiologische und intensivmedizinische Praxis, 1975, Volume: 10, Issue:1

    Topics: Diagnosis, Differential; Diazoxide; Fasting; Glucagon; Glucose Tolerance Test; Humans; Hyperinsulini

1975
Drug interaction: diazoxide and diphenylhydantoin.
    The Journal of pediatrics, 1975, Volume: 87, Issue:3

    Topics: Administration, Oral; Adolescent; Child, Preschool; Chromatography, Gas; Diazoxide; Drug Therapy, Co

1975
[Therapeutic use of diazoxide in a probable case of idiopathic hypoglycemia in an infant].
    Horumon to rinsho. Clinical endocrinology, 1975, Volume: 23, Issue:6

    Topics: Age Factors; Child, Preschool; Diazoxide; Female; Humans; Hypoglycemia

1975
Hypertrichosis due to diazoxide.
    The British journal of dermatology, 1975, Volume: 93, Issue:6

    Topics: Aged; Child; Diazoxide; Humans; Hypertension; Hypertrichosis; Hypoglycemia; Male

1975
[Leucine sensitive hypoglycemia. Follow-up studies under treatment with diazoxide (author's transl)].
    European journal of pediatrics, 1976, Mar-08, Volume: 121, Issue:4

    Topics: Blood Glucose; Diazoxide; Dietary Proteins; Drug Hypersensitivity; Epilepsy; Female; Humans; Hypertr

1976
Mechanical and ionic response of rat aorta to diazoxide.
    European journal of pharmacology, 1992, Jun-05, Volume: 216, Issue:2

    Topics: Animals; Aorta; Calcium; Calcium Radioisotopes; Diazoxide; Endothelium, Vascular; Hypoglycemia; Musc

1992
Diazoxide--an orphan drug?
    Archives of disease in childhood, 1992, Volume: 67, Issue:7

    Topics: Child, Preschool; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant; Orphan Drug Production

1992
Reactive hypoglycaemia in association with disordered islet function and abnormal hepatic glucose-6-phosphatase activity: response to diazoxide.
    Diabetic medicine : a journal of the British Diabetic Association, 1991, Volume: 8, Issue:3

    Topics: Adult; Blood Glucose; Diazoxide; Glucagon; Glucose Tolerance Test; Glucose-6-Phosphatase; Growth Hor

1991
Reversal of microcephaly and developmental delay after cure of hyperinsulinemic hypoglycemia.
    The Journal of pediatrics, 1990, Volume: 117, Issue:3

    Topics: Blood Glucose; Child, Preschool; Developmental Disabilities; Diazoxide; Female; Humans; Hypoglycemia

1990
A case of insulin-secreting tumor successfully treated with diazoxide.
    The Tokai journal of experimental and clinical medicine, 1991, Volume: 16, Issue:1

    Topics: Aged; Blood Glucose; Diazoxide; Humans; Hypoglycemia; Insulin; Insulinoma; Liver; Male; Pancreatic N

1991
Diazoxide treatment of reactive hypoglycaemia.
    Diabetic medicine : a journal of the British Diabetic Association, 1991, Volume: 8, Issue:9

    Topics: Diazoxide; Gastrectomy; Humans; Hypoglycemia

1991
Clinical spectrum of sulfonylurea overdose and experience with diazoxide therapy.
    Archives of internal medicine, 1991, Volume: 151, Issue:9

    Topics: Diazoxide; Drug Overdose; Female; Glucose Solution, Hypertonic; Humans; Hypoglycemia; Male; Manitoba

1991
Hypertrophic cardiomyopathy after prolonged diazoxide therapy for hyperinsulinemic hypoglycemia.
    The Journal of pediatrics, 1991, Volume: 118, Issue:6

    Topics: Adolescent; Cardiomyopathy, Hypertrophic; Diazoxide; Echocardiography; Humans; Hyperinsulinism; Hypo

1991
Surgical management of islet cell dysmaturation syndrome in young children.
    Surgery, gynecology & obstetrics, 1990, Volume: 171, Issue:4

    Topics: Adenoma; Combined Modality Therapy; Diazoxide; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; I

1990
Hypertrichosis induced by diazoxide in idiopathic hypoglycemia of infancy.
    Dermatologica, 1989, Volume: 179, Issue:4

    Topics: Diazoxide; Female; Humans; Hypertrichosis; Hypoglycemia; Infant, Newborn

1989
Complications of diazoxide treatment in persistent neonatal hyperinsulinism.
    Archives of disease in childhood, 1989, Volume: 64, Issue:10

    Topics: Blood Glucose; Diazoxide; Female; Heart Failure; Humans; Hyperinsulinism; Hypoglycemia; Infant; Insu

1989
Hyperinsulinism in infancy.
    Australian paediatric journal, 1989, Volume: 25, Issue:3

    Topics: Diazoxide; Diuretics; Female; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Male; Pancreas

1989
[Hyperglycemic agents].
    Pathologie-biologie, 1986, Volume: 34, Issue:3

    Topics: Blood Glucose; Chemical Phenomena; Chemistry; Diazoxide; Glucagon; Humans; Hyperglycemia; Hypoglycem

1986
The hyperinsulinaemic hypoglycaemias in infancy: a study of six cases.
    European journal of pediatrics, 1988, Volume: 148, Issue:2

    Topics: Biopsy; Blood Glucose; Diagnosis, Differential; Diazoxide; Female; Glucose Tolerance Test; Humans; H

1988
[Hypoglycemic insular tumor or insulinoma].
    Revue de l'infirmiere, 1986, Volume: 36, Issue:1

    Topics: Adenoma, Islet Cell; Diazoxide; Humans; Hypoglycemia; Insulinoma; Nervous System Diseases; Pancreate

1986
Diazoxide in the management of patients with insulinoma.
    World journal of surgery, 1986, Volume: 10, Issue:4

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Child, Preschool; Diazoxide; Edema; Female; Hir

1986
Effect of diazoxide or glucagon on hepatic glucose production rate during extreme neonatal hypoglycaemia.
    Archives of disease in childhood, 1987, Volume: 62, Issue:9

    Topics: Blood Glucose; Diazoxide; Female; Glucagon; Humans; Hypoglycemia; Infant, Newborn; Insulin; Liver; M

1987
[Acquired diffuse hypertrichosis during treatment with diazoxide in a newborn infant].
    Annales de dermatologie et de venereologie, 1988, Volume: 115, Issue:2

    Topics: Diazoxide; Humans; Hypertrichosis; Hypoglycemia; Infant, Newborn; Male

1988
Long-term treatment with diazoxide in childhood hyperinsulinism.
    Acta endocrinologica. Supplementum, 1986, Volume: 279

    Topics: Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, Newborn; Intellectual Disability;

1986
The diagnosis of hyperinsulinism in a child in the absence of hyperinsulinemia.
    The Keio journal of medicine, 1986, Volume: 35, Issue:1

    Topics: Adolescent; Diazoxide; Fatty Acids, Nonesterified; Female; Humans; Hyperinsulinism; Hypoglycemia; In

1986
Persistent neonatal hyperinsulinemic hypoglycemia in two siblings successfully treated with diazoxide.
    Helvetica paediatrica acta, 1986, Volume: 41, Issue:5

    Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Male

1986
Hypoglycemia due to organic hyperinsulinism in infancy.
    Archives of neurology, 1970, Volume: 23, Issue:4

    Topics: Adenoma, Islet Cell; Adrenal Cortex Hormones; Diazoxide; Female; Humans; Hyperinsulinism; Hyperplasi

1970
Editorial: Streptozotocin for islet-cell carcinoma.
    Lancet (London, England), 1973, Nov-10, Volume: 2, Issue:7837

    Topics: Acute Kidney Injury; Adenoma, Islet Cell; Diabetes Insipidus; Diazoxide; Drug Evaluation; Humans; Hy

1973
[Associated pancreatic insular infiltrations. Insulinoma, gastrinoma, glucagonoma. Clinical, biological, and anatomo-pathological data].
    Actualites endocrinologiques, 1973, Volume: 13, Issue:0

    Topics: Adenoma; Adult; Aged; Blood Glucose; Diazoxide; Duodenal Ulcer; Female; Gastrectomy; Gastrins; Gluca

1973
[Pancreatic adenoma and polyendocrine pathology].
    Actualites endocrinologiques, 1973, Volume: 13, Issue:0

    Topics: Adenoma; Adrenal Gland Neoplasms; Autopsy; Blood Glucose; Cholecystokinin; Diazoxide; Glucagon; Gluc

1973
Adult hypoglycaemia associated with neoplasia. A report of three cases with a note on the use of diazoxide.
    The Australian and New Zealand journal of surgery, 1966, Volume: 35, Issue:4

    Topics: Adenoma, Islet Cell; Adult; Antihypertensive Agents; Diazoxide; Female; Fibrosarcoma; Humans; Hypogl

1966
Experimental diabetes due to insulin inhibition.
    Lancet (London, England), 1968, Apr-13, Volume: 1, Issue:7546

    Topics: Animals; Chlorothiazide; Diabetes Mellitus; Diazoxide; Haplorhini; Hyperglycemia; Hypoglycemia; Insu

1968
[A morphological study on the mechanism of insulin-release, using sulfonylurea, l-leucine, and alpha-ketocarboxylic acids].
    Nihon Naibunpi Gakkai zasshi, 1968, Oct-20, Volume: 44, Issue:7

    Topics: Animals; Blood Glucose; Butyrates; Chlorpropamide; Diabetes Mellitus; Diazoxide; Ferredoxins; Histoc

1968
Treatment of insulinoma with streptozotocin.
    Lancet (London, England), 1969, Jun-14, Volume: 1, Issue:7607

    Topics: Adenoma, Islet Cell; Antibiotics, Antineoplastic; Chlorothiazide; Diazoxide; Humans; Hypoglycemia; M

1969
Effects of diazoxide administration on plasma glucose, insulin, and lipids in Von Gierke's disease.
    Diabetes, 1966, Volume: 15, Issue:6

    Topics: Antihypertensive Agents; Child; Diazoxide; Drug Eruptions; Drug Hypersensitivity; Glucose Tolerance

1966
[Organic hypoglycemia due to Langerhans carcinoma. Treatment by diazoxide followed by streptozotocin].
    Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1974, Volume: 19, Issue:5

    Topics: Aged; Carcinoma; Diazoxide; Drug Therapy, Combination; Humans; Hypoglycemia; Islets of Langerhans; L

1974
Clinical use of diazoxide and mechanism for its hyperglycemic effects.
    Diabetes, 1966, Volume: 15, Issue:3

    Topics: Adenoma, Islet Cell; Adult; Benzothiadiazines; Blood Glucose; Diabetes Mellitus; Diazoxide; Epinephr

1966
Subtotal pancreatectomy in the management of severe persistant idiopathic hypoglycemia in children.
    Pediatrics, 1967, Volume: 39, Issue:1

    Topics: Adolescent; Adrenocorticotropic Hormone; Child; Child, Preschool; Diazoxide; Diet; Ephedrine; Female

1967
Blind pancreatic resection for suspected insulinoma: a review of the problem.
    The British journal of surgery, 1967, Volume: 54, Issue:9

    Topics: Adenoma; Adenoma, Islet Cell; Adult; Aged; Diabetes Mellitus; Diazoxide; Female; Humans; Hypoglycemi

1967
Functioning islet cell adenoma in the newborn. Report of a case with failure of diazoxide.
    Pediatrics, 1968, Volume: 41, Issue:3

    Topics: Adenoma, Islet Cell; Adrenocorticotropic Hormone; Blood Glucose; Catecholamines; Corticosterone; Dia

1968
Insulin-secreting bronchial carcinoid tumor with widespread metastases.
    The American journal of medicine, 1968, Volume: 44, Issue:4

    Topics: Adult; Blood Glucose; Bronchi; Bronchial Neoplasms; Carcinoma, Adenoid Cystic; Diazoxide; Female; Gl

1968
Islet cell tumor in the neonate. Studies in carbohydrate metabolism and therapeutic response.
    Pediatrics, 1968, Volume: 41, Issue:4

    Topics: Adenoma; Adenoma, Islet Cell; Blood Glucose; Carbohydrate Metabolism; Diazoxide; Diet Therapy; Growt

1968
Further studies on diazoxide suppression of insulin release from abnormal and normal islet tissue in man.
    Annals of the New York Academy of Sciences, 1968, Apr-11, Volume: 150, Issue:2

    Topics: Adenoma, Islet Cell; Arginine; Blood Glucose; Catecholamines; Depression, Chemical; Diazoxide; Femal

1968
The therapeutic application of diazoxide in pediatric hypoglycemic states.
    Annals of the New York Academy of Sciences, 1968, Apr-11, Volume: 150, Issue:2

    Topics: Adenoma, Islet Cell; Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Glucose Tolerance Te

1968
Metabolic effects of diazoxide in normal subjects, patients with diabetes mellitus, and patients with organic hypoglycemia.
    Annals of the New York Academy of Sciences, 1968, Apr-11, Volume: 150, Issue:2

    Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; Diabetes Mellitus; Diazoxide; Fatty Acids, Nonester

1968
Control of hypoglycemia with diazoxide and hormones.
    Annals of the New York Academy of Sciences, 1968, Apr-11, Volume: 150, Issue:2

    Topics: Adenoma, Islet Cell; Adrenocorticotropic Hormone; Aged; Benzothiadiazines; Blood Glucose; Diazoxide;

1968
Clinical and physiologic studies using diazoxide in the treatment of hypoglycemia.
    Annals of the New York Academy of Sciences, 1968, Apr-11, Volume: 150, Issue:2

    Topics: Abdominal Neoplasms; Adenoma, Islet Cell; Adult; Animals; Blood Glucose; Diazoxide; Dogs; Female; Gl

1968
Clinical experience with diazoxide.
    Annals of the New York Academy of Sciences, 1968, Apr-11, Volume: 150, Issue:2

    Topics: Adenoma, Islet Cell; Adrenal Glands; Adult; Aged; Benzothiadiazines; Blood Glucose; Diabetes Mellitu

1968
[Current drug therapy of organic hypoglycemia].
    Lyon medical, 1968, Sep-08, Volume: 220, Issue:36

    Topics: Adenoma, Islet Cell; Carcinoma, Hepatocellular; Diazoxide; Female; Glucagon; Humans; Hypoglycemia; L

1968
[Apropos of a case of severe hypoglycemia. Present possibilities of diagnosis and treatment].
    Annales de pediatrie, 1968, Oct-02, Volume: 15, Issue:10

    Topics: Adenoma, Islet Cell; Blood Glucose; Diagnosis, Differential; Diazoxide; Glucocorticoids; Glucose; Gl

1968
[A case of hypoglycemic beta-langerhansian adenoma and secreting parathyroidian adenoma: polyadenomatosis].
    La Presse medicale, 1968, Dec-07, Volume: 76, Issue:48

    Topics: Adenoma; Adenoma, Islet Cell; Arginine; Diazoxide; Female; Glucagon; Growth Hormone; Humans; Hydrone

1968
[Insulin-secreting langerhansian beta-cell tumor in a woman with diabetes mellitus. Case report and literature review].
    La Presse medicale, 1969, Mar-29, Volume: 77, Issue:16

    Topics: Adenoma, Islet Cell; Diabetes Complications; Diabetic Angiopathies; Diazoxide; Humans; Hyperinsulini

1969
[Organic hypoglycemia in association with a malignant tumor and an islet cell adenoma. Determining role of blood insulin determination for the etiologic diagnosis and surgical procedure].
    La Presse medicale, 1969, Jun-14, Volume: 77, Issue:29

    Topics: Adenoma; Adenoma, Islet Cell; Aged; Arginine; Carcinoma; Diazoxide; Female; Glucagon; Glucose Tolera

1969
Pancreatic islet cell carcinoma with hyperinsulinism and probable, ectopic ACTH-MSH secretion.
    Archives of internal medicine, 1969, Volume: 124, Issue:6

    Topics: Adenoma, Islet Cell; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Blood Glucose; Diazoxide; Gl

1969
[Hypoglycemia and primary liver cancer. Hormone levels. Action of diazoxide].
    Revue medico-chirurgicale des maladies du foie, 1967, Volume: 42, Issue:3

    Topics: Adult; Carcinoma, Hepatocellular; Diazoxide; Glucagon; Growth Hormone; Humans; Hypoglycemia; Insulin

1967
[Continuous treatment with diazoxide of hypoglycemia due to hyperinsulinism].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1970, Jun-08, Volume: 46, Issue:27

    Topics: Aged; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Mental Disorders; Obesity

1970
Islet cell adenomatosis and adenoma in an infant.
    The Journal of pediatrics, 1971, Volume: 79, Issue:2

    Topics: Adenoma, Islet Cell; Adrenocorticotropic Hormone; Diazoxide; Glucose; Humans; Hypoglycemia; Infant,

1971
[Islet cell adenoma].
    Munchener medizinische Wochenschrift (1950), 1971, Sep-17, Volume: 113, Issue:28

    Topics: Adenoma, Islet Cell; Adult; Aged; Angiography; Blood Glucose; Diazoxide; Female; Humans; Hyperinsuli

1971
Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors.
    The Journal of clinical investigation, 1971, Volume: 50, Issue:10

    Topics: Acromegaly; Adenoma, Islet Cell; Adolescent; Adult; Animals; Child; Chromatography, Gel; Cricetinae;

1971
Surgical grand rounds from the University of Mississippi Medical Center. Management of hyperinsulinism.
    Southern medical journal, 1971, Volume: 64, Issue:12

    Topics: Adenoma, Islet Cell; Diagnosis, Differential; Diazoxide; Dietary Carbohydrates; Female; Glucose Tole

1971
Insulinomas: medical management as a successful alternative to surgical therapy.
    The Journal of the American Osteopathic Association, 1972, Volume: 71, Issue:5

    Topics: Adenoma, Islet Cell; Child; Diazoxide; Humans; Hypoglycemia; Male; Pancreatic Neoplasms; Radiography

1972
Beta cell adenoma in a child with hypoglycemia controlled with diazoxide.
    The Journal of pediatrics, 1972, Volume: 80, Issue:5

    Topics: Adenoma, Islet Cell; Blood Glucose; Child, Preschool; Diazoxide; Female; Glucose Tolerance Test; Hum

1972
[Diazoxide treatment of infantile hypoglycaemia].
    Wiener klinische Wochenschrift, 1972, Jun-02, Volume: 84, Issue:22

    Topics: Adenoma, Islet Cell; Diagnosis, Differential; Diazoxide; Hirsutism; Humans; Hypoglycemia; Infant; Ma

1972
Hypoglycemia due to hyperinsulinism treated by streptozotocin and diazoxide.
    Israel journal of medical sciences, 1972, Volume: 8, Issue:6

    Topics: Adenoma, Islet Cell; Adult; Anti-Bacterial Agents; Diazoxide; Drug Synergism; Female; Humans; Hyperi

1972
Pancreatic islet beta cell tumors and hyperplasia: experience in 14 Seattle hospitals.
    Annals of surgery, 1972, Volume: 175, Issue:3

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Diazoxide; Female; Humans; Hyperinsulinism; Hyp

1972
Diazoxide.
    British medical journal, 1972, Nov-18, Volume: 4, Issue:5837

    Topics: Adenoma, Islet Cell; Adult; Catecholamines; Cyclic AMP; Diazoxide; Glucose; Glycogen Storage Disease

1972
Effect of diazoxide on golden hamsters with chronic hypoglycemia due to a transplantable islet-cell tumor.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1972, Volume: 4, Issue:5

    Topics: Adenoma, Islet Cell; Administration, Oral; Adrenal Glands; Animals; Blood Glucose; Cricetinae; Diazo

1972
[Indications and medical therapy of hypoglycemic beta-insular].
    Folia endocrinologica, 1973, Volume: 26, Issue:5

    Topics: Adenoma, Islet Cell; Adrenal Cortex Hormones; Antineoplastic Agents; Carcinoma; Diazoxide; Diuretics

1973
The insulin-glucose ration in children with islet cell tumors of the pancreas.
    Clinical biochemistry, 1974, Volume: 7, Issue:1

    Topics: Adenoma, Islet Cell; Blood Glucose; Child; Diazoxide; Fasting; Glucose Tolerance Test; Humans; Hypog

1974
[Exploration of hypoglycemia].
    Revue medicale de Liege, 1974, Apr-15, Volume: 29, Issue:8

    Topics: Adenoma, Islet Cell; Arginine; Blood Glucose; Diazoxide; Diet; Fasting; Glucagon; Hormones, Ectopic;

1974
Beta-islet cell tumors of the pancreas: results of a study on 1,067 cases.
    Surgery, 1974, Volume: 75, Issue:4

    Topics: Adenoma, Islet Cell; Adult; Age Factors; Angiography; Child, Preschool; Diazoxide; Female; Glucose T

1974
Hypoglycemia in infancy caused by beta cell nesidioblastosis.
    American journal of diseases of children (1960), 1974, Volume: 128, Issue:2

    Topics: Adenoma, Islet Cell; Cell Division; Diazoxide; Humans; Hypoglycemia; Infant; Male; Microscopy, Elect

1974
[Prolonged treatment of severe hypoglycemia with diazoxide].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1974, May-08, Volume: 50, Issue:22

    Topics: Adenoma, Islet Cell; Aged; Diazoxide; Drug Eruptions; Edema; Female; Gastrointestinal Diseases; Gout

1974
Diazoxide, encorton and streptozotocin in the treatment of malignant betacytoma.
    Acta medica Polona, 1974, Volume: 15, Issue:1

    Topics: Adenoma, Islet Cell; Adult; Autopsy; Diazoxide; Female; Glucose; Humans; Hypoglycemia; Liver Neoplas

1974
Fasting hypoglycemia. Diazoxide as a test for endogenous insulin release.
    The Journal of the Kansas Medical Society, 1974, Volume: 75, Issue:11

    Topics: Adenoma, Islet Cell; Diazoxide; Fasting; Female; Humans; Hypoglycemia; Insulin; Middle Aged

1974
Pluriglandular syndrome with hyperinsulinism. Cardiomegaly as a possible complication of diazoxide therapy.
    Proceedings of the Royal Society of Medicine, 1968, Dec-12, Volume: 61, Issue:12

    Topics: Blood Glucose; Blood Pressure; Cardiomegaly; Child; Diazoxide; Female; Hirsutism; Humans; Hypercalce

1968
[Hypoglycemic islet cell adenomas, apropos of their arteriographic diagnosis and surgical treatment].
    La Presse medicale, 1969, Jan-18, Volume: 77, Issue:3

    Topics: Adenoma, Islet Cell; Angiography; Celiac Artery; Diazoxide; Duodenum; Humans; Hypoglycemia; Liver Ne

1969
[Endocrine polyadenomatosis. General review and case report].
    Annales de medecine interne, 1969, Volume: 120, Issue:4

    Topics: Adenoma; Adenoma, Islet Cell; Diazoxide; Female; Humans; Hydronephrosis; Hyperinsulinism; Hypoglycem

1969
[Treatment of idiopathic hypoglycemia with diazoxide].
    Kinderarztliche Praxis, 1974, Volume: 42, Issue:4

    Topics: Child; Diazoxide; Hirsutism; Humans; Hypoglycemia; Male; Thrombocytopenia

1974
Oral diazoxide in uncontrolled malignant hypertension.
    The Medical journal of Australia, 1974, Oct-26, Volume: 2, Issue:17

    Topics: Administration, Oral; Creatinine; Diazoxide; Edema; Furosemide; Humans; Hypertension, Malignant; Hyp

1974
Effect of drugs on carbohydrate metabolism.
    The Proceedings of the Nutrition Society, 1974, Volume: 33, Issue:3

    Topics: Adult; Blood Glucose; Caffeine; Carbohydrate Metabolism; Carbohydrate Metabolism, Inborn Errors; Chi

1974
[Proceedings: Cellular calcium and insulin secretion. Morphologic studies of B-cells in the mouse following tolbutamide and diazoxide administration].
    Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1974, Volume: 58

    Topics: Animals; Calcium; Depression, Chemical; Diazoxide; Hypoglycemia; Insulin; Insulin Secretion; Islets

1974
Metabolic aspects of the Beckwith-Wiedemann syndrome.
    The Journal of pediatrics, 1973, Volume: 82, Issue:2

    Topics: Abnormalities, Multiple; Adrenal Gland Diseases; Blood Glucose; Child, Preschool; Diazoxide; Epineph

1973
Idiopathic hypoglycaemia.
    Proceedings of the Royal Society of Medicine, 1973, Volume: 66, Issue:4

    Topics: Blood Glucose; Child, Preschool; Diazoxide; Electroencephalography; Female; Glucagon; Glucose; Growt

1973
Diazoxide therapy in the syndrome of Beckwith-Weidemann-Coombs.
    The Journal of pediatrics, 1973, Volume: 83, Issue:2

    Topics: Abnormalities, Multiple; Adrenal Gland Diseases; Blood Glucose; Child, Preschool; Diazoxide; Epineph

1973
[Current possibilities for therapy of usually untreatable hypertonic crises and hypoglycemias].
    Therapie der Gegenwart, 1973, Volume: 112, Issue:4

    Topics: Adult; Child; Diazoxide; Female; Humans; Hypertension; Hypoglycemia; Pregnancy

1973
Evaluation of diazoxide. (Hyperstat I.V.).
    JAMA, 1973, Jun-04, Volume: 224, Issue:10

    Topics: Administration, Oral; Age Factors; Blood Pressure; Cardiac Output; Child; Diazoxide; Emergencies; Ev

1973
[Extragonadal endocrine manifestations of Klinefelter's disease].
    Actualites endocrinologiques, 1973, Volume: 13, Issue:0

    Topics: Adrenal Gland Diseases; Adult; Antibodies; Autoantibodies; Blood Glucose; Diabetes Mellitus; Diazoxi

1973
[Diazoxide as therapy for idiopathic hypoglycemia in children (author's transl)].
    Monatsschrift fur Kinderheilkunde, 1974, Volume: 122, Issue:1

    Topics: Catecholamines; Child; Child, Preschool; Cyanosis; Diazoxide; Diet Therapy; Fasting; Female; Fever;

1974
Plasma insulin and blood glucose during long-term treatment with diazoxide for infant hypoglycemia.
    Acta paediatrica Scandinavica, 1974, Volume: 63, Issue:2

    Topics: Acidosis; Blood Glucose; Child, Preschool; Diazoxide; Follow-Up Studies; Glucose; Glucose Tolerance

1974
[Wiedemann-Beckwith syndrome. Clinical and metabolic study of 4 cases].
    Pediatrie, 1974, Volume: 29, Issue:2

    Topics: Abnormalities, Multiple; Child, Preschool; Diazoxide; Hernia, Umbilical; Humans; Hypoglycemia; Male;

1974
Chlorpromazine in the treatment of endogenous organic hyperinsulinism.
    Diabetologia, 1974, Volume: 10, Issue:3

    Topics: Adult; Bendroflumethiazide; Blood Glucose; Chlorpromazine; Diazoxide; Female; Glucose Tolerance Test

1974
A-cell deficiency and B-cell hyperplasia of Langerhans' islet as a cause of leucine sensitive hypoglycemia.
    Endokrinologie, 1968, Volume: 53, Issue:3

    Topics: Blood Glucose; Diazoxide; Epinephrine; Glucose Tolerance Test; Humans; Hyperplasia; Hypoglycemia; In

1968
Adenosine triphosphate levels of mammalian pancreatic B cells after stimulation with glucose and hypoglycemic sulfonylureas.
    Diabetes, 1969, Volume: 18, Issue:8

    Topics: Adenosine Triphosphate; Animals; Diazoxide; Female; Fluorometry; Glucose; Glycogen; Hyperglycemia; H

1969
Complementary arguments in favor of the betacytotrophic action of the hypglycemic sulfonamides.
    Advances in metabolic disorders, 1970, Volume: 1

    Topics: Animals; Diabetes Mellitus; Diazoxide; Dogs; Glucose; Hyperplasia; Hypoglycemia; Hypoglycemic Agents

1970
[Hyperglycemic and insulin-depressing effect of diazoxide in a case of hyperinsulinism caused by beta-insular hyperplasia].
    La Clinica terapeutica, 1971, Feb-15, Volume: 56, Issue:3

    Topics: Aged; Blood Glucose; Diazoxide; Female; Humans; Hyperplasia; Hypoglycemia; Insulin; Insulin Secretio

1971
Leucine-sensitive hypoglycaemia treated with diazoxide.
    Archives of disease in childhood, 1967, Volume: 42, Issue:224

    Topics: Blood Glucose; Diazoxide; Female; Humans; Hypoglycemia; Infant; Infant, Newborn; Leucine; Male

1967
Leucine-sensitive hypoglycaemia.
    Proceedings of the Royal Society of Medicine, 1970, Volume: 63, Issue:4

    Topics: Adolescent; Diazoxide; Diet Therapy; Epilepsy, Tonic-Clonic; Female; Humans; Hypoglycemia; Leucine

1970
Clinical value and mode of action of chlorpropamide in diabetes insipidus.
    The American journal of the medical sciences, 1970, Volume: 260, Issue:6

    Topics: Adolescent; Adult; Chlorpropamide; Diabetes Insipidus; Diazoxide; Drinking Behavior; Female; Humans;

1970
Neonatal hypoglycemia: a discussion.
    The Journal of pediatrics, 1971, Volume: 79, Issue:2

    Topics: Anticonvulsants; Diazoxide; Diet Therapy; Epinephrine; Female; Glucagon; Glucose; Glucose Tolerance

1971
Ketotic (idiopathic glucagon unresponsive) hypoglycaemia: diazoxide effects.
    Archives of disease in childhood, 1972, Volume: 47, Issue:254

    Topics: Acidosis; Birth Weight; Blood Glucose; Child; Child, Preschool; Diazoxide; Fasting; Female; Glucagon

1972
[Value of diazoxide in the treatment of neonatal hypoglycemia].
    La Nouvelle presse medicale, 1972, Jan-01, Volume: 1, Issue:1

    Topics: Blood Glucose; Diazoxide; Female; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases;

1972
[Effects of prolonged treatment with Diazoxide in 2 cases of spontaneous hypoglycemia in adults].
    Minerva medica, 1971, May-09, Volume: 62, Issue:37

    Topics: Adult; Bendroflumethiazide; Diazoxide; Humans; Hypoglycemia; Insulin; Male; Middle Aged; Water-Elect

1971
[Diazoxide in the therapy of leucin sensitive hypoglycemia].
    Monatsschrift fur Kinderheilkunde, 1971, Volume: 119, Issue:7

    Topics: Carbohydrate Metabolism, Inborn Errors; Diazoxide; Humans; Hyperinsulinism; Hypertrichosis; Hypoglyc

1971
The clinical use of diazoxide in leucine-sensitive hypoglycemia.
    Annals of the New York Academy of Sciences, 1968, Apr-11, Volume: 150, Issue:2

    Topics: Amino Acid Metabolism, Inborn Errors; Child, Preschool; Diazoxide; Female; Humans; Hyperglycemia; Hy

1968
The use of diazoxide in hypoglycemia in childhood.
    Annals of the New York Academy of Sciences, 1968, Apr-11, Volume: 150, Issue:2

    Topics: Amino Acid Metabolism, Inborn Errors; Blood Glucose; Child; Child, Preschool; Diazoxide; Glucocortic

1968
Hypertrichosis lanuginosa associated with diazoxide therapy in prepubertal children: a clinicopathologic study.
    Annals of the New York Academy of Sciences, 1968, Apr-11, Volume: 150, Issue:2

    Topics: Androgens; Child, Preschool; Diazoxide; Female; Hair; Humans; Hypertrichosis; Hypoglycemia; Infant;

1968
Studies in a patient with retroperitoneal sarcoma associated with severe hypoglycemia.
    Annals of the New York Academy of Sciences, 1968, Apr-11, Volume: 150, Issue:2

    Topics: Aged; Blood Glucose; Diazoxide; Female; Glucagon; Glucose Tolerance Test; Humans; Hypoglycemia; Infu

1968
Diazoxide therapy of intractable hypoglycemia.
    Annals of the New York Academy of Sciences, 1968, Apr-11, Volume: 150, Issue:2

    Topics: Adrenal Medulla; Adult; Benzothiadiazines; Blood Glucose; Child, Preschool; Diazoxide; Epinephrine;

1968
Clinical studies in the use of oral diazoxide in postsurgical and functional hypoglycemia.
    The Medical annals of the District of Columbia, 1968, Volume: 37, Issue:9

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Blood Glucose; Catecholamines; Diazox

1968
New approaches to medical management of organic hypoglycemias.
    Proceedings of the Rudolf Virchow Medical Society in the City of New York, 1966, Volume: 25

    Topics: Child, Preschool; Diazoxide; Diuretics; Humans; Hypoglycemia; Sulfanilamides

1966
Hepatic glycogen storage disease. Clinical and laboratory findings in 23 cases.
    The Quarterly journal of medicine, 1971, Volume: 40, Issue:157

    Topics: Child; Child, Preschool; Diazoxide; Diet Therapy; Female; Fructose; Galactose; Glucose Tolerance Tes

1971
A possible role for the exocrine pancreas in the pathogenesis of neonatal leucine-sensitive hypoglycemia.
    The American journal of digestive diseases, 1970, Volume: 15, Issue:1

    Topics: Diazoxide; Exocrine Glands; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Leucin

1970
Diazoxide for hyperinsulinism.
    Drug and therapeutics bulletin, 1970, Mar-13, Volume: 8, Issue:6

    Topics: Adult; Animals; Child; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia

1970
[Treatment of hypoglycemia in children by diazoxide and immunoreactive insulin depressive action].
    Horumon to rinsho. Clinical endocrinology, 1970, Volume: 18, Issue:4

    Topics: Blood Glucose; Child, Preschool; Diazoxide; Female; Humans; Hypoglycemia; Infant; Insulin; Insulin S

1970
Contribution to the pathogenesis of tumour hypoglycaemia.
    European journal of clinical investigation, 1970, Volume: 1, Issue:1

    Topics: Blood Glucose; Diazoxide; Fatty Acids, Nonesterified; Fibrosarcoma; Gluconeogenesis; Glycolysis; Hum

1970
[The use of Diazoxid in spontaneous hypoglycemia syndrome].
    Orvosi hetilap, 1970, Oct-04, Volume: 111, Issue:40

    Topics: Adult; Aged; Diazoxide; Female; Humans; Hypoglycemia; Middle Aged

1970
[Initial hypoglycemic manifestations in a familial form of isolated somatotropin deficiency].
    Annales de pediatrie, 1970, Nov-02, Volume: 17, Issue:11

    Topics: Blood Glucose; Body Height; Carbohydrate Metabolism, Inborn Errors; Child, Preschool; Diazoxide; Dwa

1970
The critically ill child: hypoglycemia.
    Pediatrics, 1970, Volume: 46, Issue:6

    Topics: Child; Diazoxide; Endocrine System Diseases; Fasting; Glucose; Humans; Hypoglycemia; Infant; Infant,

1970
AO44: an improved hyperglycemic agent.
    Metabolism: clinical and experimental, 1971, Volume: 20, Issue:4

    Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Diazoxide; Diuresis; Dogs; Epinephrine

1971
Ketotic hypoglycemia. New observations.
    The Journal of the Florida Medical Association, 1971, Volume: 58, Issue:5

    Topics: Acidosis; Blood Glucose; Child; Diazoxide; Ephedrine; Glucagon; Glucose; Humans; Hypoglycemia; Keton

1971
[Diazoxide therapy of spontaneous hypoglycemia].
    Orvosi hetilap, 1967, Oct-15, Volume: 108, Issue:42

    Topics: Diazoxide; Humans; Hypoglycemia

1967
[Clinical observations and experimental findings in the treatment of hyperinsulinism with diazoxide].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1967, Volume: 73

    Topics: Animals; Diazoxide; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemia

1967
[Hypoglycemia in the course of secondary liver neoplasm].
    Lyon medical, 1968, Sep-08, Volume: 220, Issue:36

    Topics: Diazoxide; Glucagon; Humans; Hypoglycemia; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis

1968
[Can organic hypoglycemia in adults be medically treated?].
    Semaine therapeutique, 1968, Volume: 44, Issue:3

    Topics: Adrenal Cortex Hormones; Adult; Age Factors; Diazoxide; Diet Therapy; Drug Synergism; Hormones; Huma

1968
Idiopathic neonatal hypoglycaemia treated with diazoxide.
    Proceedings of the Royal Society of Medicine, 1969, Volume: 62, Issue:1

    Topics: Diazoxide; Female; Glucagon; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Pancr

1969
Diazoxide in the management of hypoglycemia in infancy and childhood.
    American journal of diseases of children (1960), 1969, Volume: 117, Issue:4

    Topics: Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Glucose; Glucose Tolerance Test; Growth H

1969
Hypertichosis lanuginosa acquisita.
    Archives of dermatology, 1969, Volume: 99, Issue:6

    Topics: Diazoxide; Humans; Hypertrichosis; Hypoglycemia; Infant; Leucine; Male; Pancreatectomy; Seizures

1969
A fatal reaction to diazoxide.
    Postgraduate medical journal, 1969, Volume: 45, Issue:519

    Topics: Anuria; Diazoxide; Female; Fibrosarcoma; Humans; Hypoglycemia; Middle Aged; Pleural Neoplasms; Radio

1969
Importance of dissolution rates in producing effective diazoxide blood levels in man.
    Journal of pharmaceutical sciences, 1965, Volume: 54, Issue:9

    Topics: Aged; Blood; Blood Pressure; Diazoxide; Female; Glucose; Humans; Hypertension; Hypoglycemia; Injecti

1965
The treatment of hypoglycaemia with diazoxide.
    Proceedings of the Royal Society of Medicine, 1966, Volume: 59, Issue:9

    Topics: Blood Glucose; Child, Preschool; Diazoxide; Glucose Tolerance Test; Humans; Hypoglycemia; Infant; Ma

1966
Leucine-sensitive hypoglycemia. Treatment with zinc glucagon and corticosteroids.
    The American journal of medicine, 1966, Volume: 41, Issue:4

    Topics: Diazoxide; Diet; Female; Glucagon; Humans; Hypoglycemia; Leucine; Middle Aged; Prednisone

1966
Effect of treatment with diazoxide and chlorothiazide on a child with leucine-sensitive hypoglycaemia.
    British medical journal, 1966, Dec-17, Volume: 2, Issue:5528

    Topics: Child, Preschool; Chlorothiazide; Diazoxide; Female; Glucose Tolerance Test; Humans; Hypoglycemia; L

1966
Diazoxide in the treatment of infantile hypoglycemia.
    The New England journal of medicine, 1966, Dec-29, Volume: 275, Issue:26

    Topics: Autoanalysis; Diazoxide; Drug Hypersensitivity; Female; Glucose Tolerance Test; Hirsutism; Humans; H

1966
[Treatment with diazoxide of a case of infantile hypoglycemia].
    Rivista di clinica pediatrica, 1966, Volume: 77, Issue:5

    Topics: Blood Glucose; Diazoxide; Electroencephalography; Humans; Hypoglycemia; Infant; Male; Trichlormethia

1966