diazoxide has been researched along with Fasting Hypoglycemia in 340 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Fasting Hypoglycemia: HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diazoxide is the first-line drug for treating hyperinsulinism and the only pharmacological agent approved for hyperinsulinism by the Federal Drug Administration." | 9.12 | Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis. ( Chen, X; Feng, L; Qin, Y; Yang, L; Yao, H, 2021) |
| "The diagnosis of hypoglycemia and the use of diazoxide have risen in the last decade." | 7.96 | Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism. ( Brar, PC; Cossen, K; De Leon, DD; Heksch, R; Kamboj, MK; Marks, SD; Marshall, BA; Miller, R; Mitchell, D; Page, L; Stanley, T; Thornton, P, 2020) |
| "The aim of the study was to characterize factors that may serve as clinical tools to identify neonates with transient neonatal hyperinsulinism hypoglycemia (HH) who may benefit from diazoxide treatment." | 7.96 | Higher C-peptide levels and glucose requirements may identify neonates with transient hyperinsulinism hypoglycemia who will benefit from diazoxide treatment. ( Davidov, AS; Elkon-Tamir, E; Eyal, O; Haham, A; Lebenthal, Y; Mandel, D; Oren, A; Shefer, G; Weintrob, N, 2020) |
| "Diazoxide is first-line treatment for hyperinsulinaemic hypoglycaemia (HH) but diazoxide-induced pulmonary hypertension (PH) can occur." | 7.91 | Diazoxide-induced pulmonary hypertension in hyperinsulinaemic hypoglycaemia: Recommendations from a multicentre study in the United Kingdom. ( Aftab, S; Banerjee, I; Bath, L; Chen, SC; Christov, G; Dastamani, A; Giardini, A; Hunter, L; Pintus, D; Senniappan, S; Shah, P; Shaikh, MG; Swinburne, C; Yau, D, 2019) |
| " The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia." | 7.81 | Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide. ( Aso, Y; Hiraishi, H; Kojima, M; Shimizu, M; Suzuki, K; Tsuchida, K, 2015) |
| "Recessive mutations in the hydroxyacyl-CoA dehydrogenase (HADH) gene encoding the enzyme 3-hydroxyacyl-CoA dehydrogenase are a rare cause of diazoxide-responsive hyperinsulinemic hypoglycemia (HH) with just five probands reported to date." | 7.77 | Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees. ( Akcay, T; Alaei, M; Desai, M; Ellard, S; Flanagan, SE; Hussain, K; Kapoor, RR; Locke, JM; Patch, AM; Simsek, E; Yekta, Z, 2011) |
| "Diazoxide is the main therapeutic agent for persistent hyperinsulinemic hypoglycemia." | 7.77 | Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide. ( Arasli, A; Çetin, II; Demirel, F; Esen, I; Unal, S, 2011) |
| "The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY)." | 7.76 | Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. ( Akcay, T; Banerjee, I; Cody, D; Ellard, S; Flanagan, SE; Hussain, K; Kapoor, RR; Mali, G; Murphy, N; Rubio-Cabezas, O; Schwahn, B; Shield, JP; Siahanidou, T, 2010) |
| "Diazoxide is commonly used in the treatment of neonatal hyperinsulinism." | 7.74 | Development of pulmonary hypertension in an infant treated with diazoxide. ( Caldwell, RL; Eugster, EA; Hoover, WC; Nebesio, TD; Nitu, ME, 2007) |
| "The intraislet insulin hypothesis for the signaling of the glucagon secretory response to hypoglycemia states that a decrease in arterial glucose --> a decrease in beta-cell insulin secretion --> a decrease in tonic alpha-cell inhibition by insulin --> an increase in alpha-cell glucagon secretion." | 7.73 | Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans. ( Cryer, PE; Raju, B, 2005) |
| "The present report describes a mother and 2 children with leucine-induced hypoglycemia (LIH)." | 7.67 | Leucine-induced hypoglycemia in a family: effect of diphenylhydantoin, oxprenolol, and diazoxide. ( Colin, AA; Guttman, H; Hochberg, Z; Spindel, A, 1984) |
| "Diazoxide, as demonstrated by the case we present, may be of substantial value in abolishing hypoglycemia and in preventing its recurrence." | 7.66 | Management of chlorpropamide-induced hypoglycemia with diazoxide. ( Pfeifer, MA; Samols, E; Wolter, CF, 1978) |
| "Four children, treated with diazoxide for idiopathic leucine-sensitive (ILS) hypoglycemia of infancy, had follow-up studies at 2 to 10 yr of age to assess: (1) persistence of leucine sensitivity in later childhood." | 7.66 | Idiopathic leucine-sensitive hypoglycemia syndrome: insulin and glucagon responses and effects of diazoxide. ( Kogut, MD; Roe, TF, 1982) |
| "Two cases of hypertrichosis due to diazoxide are described." | 7.65 | Hypertrichosis due to diazoxide. ( Burton, JL; Caldwell, IW; Schutt, WH, 1975) |
| "Twelve patients with either severe preeclampsia (9) or eclampsia (3) were treated with intravenous diazoxide, 300-mg bolus, for the reduction of diastolic blood pressure (less than or equal 110 torr) after the usual and customary measures had been initiated to include parenteral MgSO4 and diazepam." | 7.65 | The management of severe preeclampsia and eclampsia with intravenous diazoxide. ( Arce, JJ; Bloom, RS; Clark, JH; Davidson, EC; Hamilton, CJ; Maidman, JE; Morris, JA, 1977) |
| " Glucose therapy alone was not sufficient to control the hypoglycemia, but the administration of glucose plus diazoxide raised the blood sugar to supranormal levels." | 7.65 | Chlorpropamide-induced hypoglycemia: successful treatment with diazoxide. ( Johnson, SF; Peake, GT; Schade, DS, 1977) |
| "Since 1969 leucine sensitive hypoglycemia has been diagnosed in 4 infants." | 7.65 | [Leucine sensitive hypoglycemia. Follow-up studies under treatment with diazoxide (author's transl)]. ( Lücking, T, 1976) |
| "Individuals with long-standing type 1 diabetes (T1D) are at increased risk of severe hypoglycemia secondary to impairments in normal glucose counterregulatory responses (CRRs)." | 6.80 | Diazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long-standing type 1 diabetes. ( George, PS; McCrimmon, RJ; Palmer, CN; Tavendale, R, 2015) |
| "Diazoxide was originally approved as an anti-hypertensive medication, but also is known to bind ATP-sensitive K channels in the beta cells of the pancreas, ultimately leading to inhibition of insulin release." | 5.56 | The use of diazoxide in the management of spontaneous hypoglycemia in patients with ESRD. ( Kristan, M; Lamos, EM; Malek, R; Mesmar, B; Munir, KM; Satyarengga, M, 2020) |
| "Diazoxide is a non-diuretic benzothiadiazine derivative, one of a group of substances introduced into clinical practice in the 1950s for the treatment of hypertension." | 5.43 | Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( Inoue, Y; Komatsu, Y; Miyoshi, H; Nakamura, A; Tajima, K; Takano, T; Takihata, M; Terauchi, Y; Tsuchiya, H; Yahagi, S; Yamakawa, T; Yoshida, M, 2016) |
| "Cardiorespiratory failure (toxicity) occurred on eight of the 11 occasions (73%) in seven infants." | 5.28 | Complications of diazoxide treatment in persistent neonatal hyperinsulinism. ( Abu-Osba, YK; Manasra, KB; Mathew, PM, 1989) |
| "Diazoxide (10 mg/kg/d) was successful in controlling hypoglycemia for eight years and one year, respectively, without serious side effects." | 5.27 | Persistent neonatal hyperinsulinemic hypoglycemia in two siblings successfully treated with diazoxide. ( Schubiger, G; Wüthrich, C; Zuppinger, K, 1986) |
| "Diazoxide is the first-line drug for treating hyperinsulinism and the only pharmacological agent approved for hyperinsulinism by the Federal Drug Administration." | 5.12 | Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis. ( Chen, X; Feng, L; Qin, Y; Yang, L; Yao, H, 2021) |
| " Medical control of the hormonal syndrome with agents such as diazoxide for insulinoma, omeprazole for gastrinoma, and octreotide for vipoma and glucagonoma allows an orderly and thorough investigation for associated endocrinopathies and comorbid medical conditions." | 4.79 | Islet cell tumors. ( Stabile, BE, 1997) |
| "Given that reports on severe diazoxide (DZX) toxicity are increasing, we aimed to understand if the short-term clinical outcomes of small-for-gestational-age (SGA) infants with hyperinsulinemic hypoglycemia (HH) managed primarily by supportive care, termed watchful waiting (WW), are different from those treated with DZX." | 4.31 | Watchful waiting versus pharmacological management of small-for-gestational-age infants with hyperinsulinemic hypoglycemia. ( Chandran, S; Chua, MC; Jaya-Bodestyne, SL; Rajadurai, VS; Saffari, SE; Yap, F, 2023) |
| "The diagnosis of hypoglycemia and the use of diazoxide have risen in the last decade." | 3.96 | Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism. ( Brar, PC; Cossen, K; De Leon, DD; Heksch, R; Kamboj, MK; Marks, SD; Marshall, BA; Miller, R; Mitchell, D; Page, L; Stanley, T; Thornton, P, 2020) |
| "The aim of the study was to characterize factors that may serve as clinical tools to identify neonates with transient neonatal hyperinsulinism hypoglycemia (HH) who may benefit from diazoxide treatment." | 3.96 | Higher C-peptide levels and glucose requirements may identify neonates with transient hyperinsulinism hypoglycemia who will benefit from diazoxide treatment. ( Davidov, AS; Elkon-Tamir, E; Eyal, O; Haham, A; Lebenthal, Y; Mandel, D; Oren, A; Shefer, G; Weintrob, N, 2020) |
| "Diazoxide is first-line treatment for hyperinsulinaemic hypoglycaemia (HH) but diazoxide-induced pulmonary hypertension (PH) can occur." | 3.91 | Diazoxide-induced pulmonary hypertension in hyperinsulinaemic hypoglycaemia: Recommendations from a multicentre study in the United Kingdom. ( Aftab, S; Banerjee, I; Bath, L; Chen, SC; Christov, G; Dastamani, A; Giardini, A; Hunter, L; Pintus, D; Senniappan, S; Shah, P; Shaikh, MG; Swinburne, C; Yau, D, 2019) |
| "Diazoxide is used to treat infants with persistent hypoglycemia, but the prevalence of its use and adverse effects are not well described." | 3.88 | Prevalence and safety of diazoxide in the neonatal intensive care unit. ( Benjamin, DK; Benjamin, R; Clark, RH; Cotten, CM; Dudash, K; Escobar, C; Freel, C; Gray, KD; Greenberg, RG; Harrison, T; McMillan, C; Puia-Dumitrescu, M, 2018) |
| " The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia." | 3.81 | Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide. ( Aso, Y; Hiraishi, H; Kojima, M; Shimizu, M; Suzuki, K; Tsuchida, K, 2015) |
| "This case series follows the evolving course of three patients with confirmed HNF4A-mediated congenital hyperinsulinism, highlighting (1) the variable natural history of these mutations, (2) the potential for prolonged diazoxide requirement, even into adolescence, and (3) the need for screening, regardless of family history." | 3.80 | The evolving course of HNF4A hyperinsulinaemic hypoglycaemia--a case series. ( Ellard, S; Flanagan, SE; Hawkes, CP; McDonnell, CM; McGlacken-Byrne, SM; Murphy, NP, 2014) |
| "The authors report a macrosomic term male infant who developed refractory hyperinsulinism requiring 20 mg/kg/min intravenous dextrose (usual range 4-6 mg/kg/min) and treatment with diazoxide 10 mg/kg/day." | 3.77 | Neonatal hyperinsulinism secondary to maternal intake of high-sugar drinks. ( Thorpe, M; West, NJ, 2011) |
| "Recessive mutations in the hydroxyacyl-CoA dehydrogenase (HADH) gene encoding the enzyme 3-hydroxyacyl-CoA dehydrogenase are a rare cause of diazoxide-responsive hyperinsulinemic hypoglycemia (HH) with just five probands reported to date." | 3.77 | Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees. ( Akcay, T; Alaei, M; Desai, M; Ellard, S; Flanagan, SE; Hussain, K; Kapoor, RR; Locke, JM; Patch, AM; Simsek, E; Yekta, Z, 2011) |
| "Diazoxide is the main therapeutic agent for persistent hyperinsulinemic hypoglycemia." | 3.77 | Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide. ( Arasli, A; Çetin, II; Demirel, F; Esen, I; Unal, S, 2011) |
| "The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY)." | 3.76 | Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. ( Akcay, T; Banerjee, I; Cody, D; Ellard, S; Flanagan, SE; Hussain, K; Kapoor, RR; Mali, G; Murphy, N; Rubio-Cabezas, O; Schwahn, B; Shield, JP; Siahanidou, T, 2010) |
| "Diazoxide is commonly used in the treatment of neonatal hyperinsulinism." | 3.74 | Development of pulmonary hypertension in an infant treated with diazoxide. ( Caldwell, RL; Eugster, EA; Hoover, WC; Nebesio, TD; Nitu, ME, 2007) |
| "We define a syndrome of prolonged neonatal hyperinsulinism that is responsive to diazoxide, persists for several months, and resolves spontaneously." | 3.73 | Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism. ( Hoe, FM; Simmons, RA; Stanley, CA; Steinkrauss, L; Thornton, PS; Wanner, LA, 2006) |
| "The intraislet insulin hypothesis for the signaling of the glucagon secretory response to hypoglycemia states that a decrease in arterial glucose --> a decrease in beta-cell insulin secretion --> a decrease in tonic alpha-cell inhibition by insulin --> an increase in alpha-cell glucagon secretion." | 3.73 | Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans. ( Cryer, PE; Raju, B, 2005) |
| " A mutation in the second nucleotide-binding fold (NBF2) of the sulfonylurea receptor (SUR) of an individual diagnosed with persistent hyperinsulinemic hypoglycemia of infancy generated KATP channels that could be opened by diazoxide but not in response to metabolic inhibition." | 3.69 | Adenosine diphosphate as an intracellular regulator of insulin secretion. ( Aguilar-Bryan, L; Bryan, J; Clement, JP; Glaser, B; Gonzalez, G; Nestorowicz, A; Nichols, CG; Permutt, MA; Shyng, SL, 1996) |
| " We describe a 72-year-old lady who initially presented with episodic hypoglycemia secondary to an insulinoma that was controlled by diazoxide." | 3.69 | Relapse of medically treated insulinoma following the development of thyrotoxicosis: an assessment of potential mechanisms. ( Alberti, KG; Kendall-Taylor, P; Trajano, LR; Walker, M, 1994) |
| "Serum concentrations of pancreatic glucagon were measured in 40 patients with hyperinsulinemic hypoglycemia." | 3.69 | Pancreatic glucagon levels in infants and children with hyperinsulinemia. ( Cedro, A; Gruszczyńska, B; Kamiński, W; Leśniewska, A; Pronicka, E; Woźniewicz, B, 1995) |
| " Following diagnosis of hyperinsulinemic hypoglycemia, this patient was treated with oral diazoxide." | 3.68 | Prenatal diagnosis of familial neonatal hyperinsulinemia. ( Aparicio, L; Carpenter, MW; Gruppuso, PA; Schwartz, R, 1993) |
| "The present report describes a mother and 2 children with leucine-induced hypoglycemia (LIH)." | 3.67 | Leucine-induced hypoglycemia in a family: effect of diphenylhydantoin, oxprenolol, and diazoxide. ( Colin, AA; Guttman, H; Hochberg, Z; Spindel, A, 1984) |
| "Hyperinsulinemic hypoglycemia secondary to nesidioblastosis persisted in a 4-year-old girl despite a 95% pancreatectomy and high-dose diazoxide treatment." | 3.66 | Persistent leucine sensitivity following partial pancreatectomy and diazoxide treatment. Therapeutic response. ( Bradvica, C; Golden, MP; Graham, MJ; Santiago, J; Sargeant, DT; White, NH; Zuniga, O, 1983) |
| "4 children with ketotic hypoglycemia (KH) showed during a fasting period over 24 hours significant higher decreases of serum alanine levels than normal controls." | 3.66 | [Pathogenesis of ketotic hypoglycemia (author's transl)]. ( Ploier, R; Sommer, R; Tulzer, W, 1979) |
| "Diazoxide, as demonstrated by the case we present, may be of substantial value in abolishing hypoglycemia and in preventing its recurrence." | 3.66 | Management of chlorpropamide-induced hypoglycemia with diazoxide. ( Pfeifer, MA; Samols, E; Wolter, CF, 1978) |
| "Four children, treated with diazoxide for idiopathic leucine-sensitive (ILS) hypoglycemia of infancy, had follow-up studies at 2 to 10 yr of age to assess: (1) persistence of leucine sensitivity in later childhood." | 3.66 | Idiopathic leucine-sensitive hypoglycemia syndrome: insulin and glucagon responses and effects of diazoxide. ( Kogut, MD; Roe, TF, 1982) |
| " The enzyme in the insulinomas, but not that in the nearby pancreases, was inhibited by diazoxide, which is a known inhibitor of insulin secretion in vitro and in vivo." | 3.66 | Increased mitochondrial glycerol phosphate dehydrogenase activity in insulinomas of two hypoglycemic infants. ( MacDonald, MJ; Pellett, JR; Warner, TF, 1983) |
| "Twelve patients with either severe preeclampsia (9) or eclampsia (3) were treated with intravenous diazoxide, 300-mg bolus, for the reduction of diastolic blood pressure (less than or equal 110 torr) after the usual and customary measures had been initiated to include parenteral MgSO4 and diazepam." | 3.65 | The management of severe preeclampsia and eclampsia with intravenous diazoxide. ( Arce, JJ; Bloom, RS; Clark, JH; Davidson, EC; Hamilton, CJ; Maidman, JE; Morris, JA, 1977) |
| " Glucose therapy alone was not sufficient to control the hypoglycemia, but the administration of glucose plus diazoxide raised the blood sugar to supranormal levels." | 3.65 | Chlorpropamide-induced hypoglycemia: successful treatment with diazoxide. ( Johnson, SF; Peake, GT; Schade, DS, 1977) |
| "In two children treated for hypoglycemia and convulsions with diazoxide and diphenylhydantoin, therapeutic serum diphenylhydantoin levels were not achieved despite doses of diphenylhydantoin of 17 and 29 mg/kg/day, respectively." | 3.65 | Drug interaction: diazoxide and diphenylhydantoin. ( Blaskovics, ME; Podosin, RL; Roe, TF, 1975) |
| "Two cases of hypertrichosis due to diazoxide are described." | 3.65 | Hypertrichosis due to diazoxide. ( Burton, JL; Caldwell, IW; Schutt, WH, 1975) |
| "Since 1969 leucine sensitive hypoglycemia has been diagnosed in 4 infants." | 3.65 | [Leucine sensitive hypoglycemia. Follow-up studies under treatment with diazoxide (author's transl)]. ( Lücking, T, 1976) |
| "Diazoxide is one such treatment that acts on the pancreatic β-cell in a dose-dependent manner to decrease insulin secretion." | 3.11 | Oral diazoxide versus placebo for severe or recurrent neonatal hypoglycaemia: Neonatal Glucose Care Optimisation (NeoGluCO) study - a randomised controlled trial. ( Alsweiler, JM; Ardern, J; Chase, JG; Cutfield, WS; Gamble, GD; Hanning, SM; Harding, JE; Laing, D; McKinlay, CJ; Meyer, MP; Rogers, J; Walsh, E, 2022) |
| "Individuals with long-standing type 1 diabetes (T1D) are at increased risk of severe hypoglycemia secondary to impairments in normal glucose counterregulatory responses (CRRs)." | 2.80 | Diazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long-standing type 1 diabetes. ( George, PS; McCrimmon, RJ; Palmer, CN; Tavendale, R, 2015) |
| "Diazoxide treatment reduced A1C from 8." | 2.75 | Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control. ( Dørflinger, GH; Grill, V; Hals, I; Kollind, M; Moen, T; Nermoen, I; Radtke, MA; Skeie, S; Svartberg, J; Sørheim, JI, 2010) |
| "Congenital hyperinsulinism is a genetic condition causing dysregulation of insulin and results in persistent hypoglycemia." | 2.50 | Congenital hyperinsulinism: exclusive human milk and breastfeeding. ( Edwards, TM; Spatz, DL, 2014) |
| "Neonatal hypoglycemia is one of the most common biochemical abnormalities encountered in the newborn." | 2.50 | Update on neonatal hypoglycemia. ( Rozance, PJ, 2014) |
| "Hyperinsulinism is a heterogeneous disorder characterised by severe hypoglycaemia due to an inappropriate oversecretion of insulin." | 2.41 | Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases. ( Bellane-Chantelot, C; Brunelle, F; Brusset, MC; Chigot, V; de Lonlay, P; Delagne, V; Fournet, JC; Groos, MS; Junien, C; Laborde, K; Martin, D; Mayaud, C; Nihoul-Fékété, C; Rahier, J; Robert, JJ; Saudubray, JM; Sempoux, C; Sevin, C; Touati, G; Vassault, A, 2002) |
| "Initial interventions for hyperinsulinemia are conservative." | 2.41 | When it is more than transient neonatal hypoglycemia: hyperinsulinemia--a case study challenge. ( Shirland, L, 2001) |
| "Diazoxide was commenced in 28 patients (82." | 1.72 | Clinical and genetic heterogeneity of HNF4A/HNF1A mutations in a multicentre paediatric cohort with hyperinsulinaemic hypoglycaemia. ( Brusgaard, K; Christesen, H; Conlon, N; Dastamani, A; Demirbilek, H; Flanagan, SE; Gubaeva, D; Houghton, JAL; McGlacken-Byrne, SM; Melikyan, M; Mohammad, JK; Murphy, NP; Schou, AJ; Shah, P; Siersbæk, J, 2022) |
| "Hyperinsulinism was permanent in two of these three cases." | 1.72 | Hyperinsulinism May Be Underreported in Hypoglycemic Patients with Phosphomannomutase 2 Deficiency ( Alikaşifoğlu, A; Dursun, A; Gönç, N; Ozon, A; Sivri, HS; Tokatlı, A; Vurallı, D; Yıldız, Y, 2022) |
| "Hypoglycemia was not repeated on endocrinological examination, even while fasting." | 1.72 | Diagnosis and Treatment Course of Insulinoma Presenting as Hypoglycemia Unawareness Using a Factory-Calibrated Continuous Glucose Monitoring System. ( Aida, A; Noto, H, 2022) |
| "This syndrome is characterised by recurrent episodes of hypoglycaemia and elevated ammonia levels, which are potentially harmful to both the patient and a developing fetus." | 1.56 | Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome. ( Bazelmans, M; Benner, BJM; Huidekoper, H; Langendonk, J; Langeveld, M; Schoenmakers, S, 2020) |
| "Transient hyperinsulinism are the most common cause of severe hypoglycemia in newborns." | 1.56 | [Transient hyperinsulinism in neonates]. ( Bockeria, EL; Bolmasova, AV; Degtyareva, AV; Ionov, OV; Krylova, NA; Melikyan, MA; Pekareva, NA; Ryumina, II, 2020) |
| "Diazoxide was originally approved as an anti-hypertensive medication, but also is known to bind ATP-sensitive K channels in the beta cells of the pancreas, ultimately leading to inhibition of insulin release." | 1.56 | The use of diazoxide in the management of spontaneous hypoglycemia in patients with ESRD. ( Kristan, M; Lamos, EM; Malek, R; Mesmar, B; Munir, KM; Satyarengga, M, 2020) |
| "BACKGROUND Hypoglycemia is rare in individuals without drug-treated diabetes mellitus." | 1.56 | Changing Insulinoma Management Due to Incidentally Discovered Metastasis: A Case Report. ( Chow, LS; Froelich, J; Madan, R; Mettler, T, 2020) |
| "Nesidioblastosis is a rare cause of adult hypoglycemia." | 1.51 | A Case Report of Insulinoma Relapse on Background Nesidioblastosis: A Rare Cause of Adult Hypoglycemia. ( Bonora, E; Castelli, C; Dauriz, M; Ferdeghini, M; Fuini, A; Landoni, L; Malleo, G; Maneschi, C; Moghetti, P; Tomezzoli, A, 2019) |
| "Diazoxide is a non-diuretic benzothiadiazine derivative, one of a group of substances introduced into clinical practice in the 1950s for the treatment of hypertension." | 1.43 | Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( Inoue, Y; Komatsu, Y; Miyoshi, H; Nakamura, A; Tajima, K; Takano, T; Takihata, M; Terauchi, Y; Tsuchiya, H; Yahagi, S; Yamakawa, T; Yoshida, M, 2016) |
| "Most cases of insulinomas are benign." | 1.43 | A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma. ( Berberabe, A; Pagsisihan, D; Palugod-Lopez, EG; Sandoval, MA, 2016) |
| "Hyperinsulinism was diagnosed as hypoglycemia concomitant with high serum insulin in babies requiring >6 mg/kg/min intravenous glucose and THI as hyperinsulinism without maternal diabetes or genetic disorders." | 1.42 | Fetal Erythroblastosis May Be an Indicator of Neonatal Transient Hyperinsulinism. ( Hata, D; Iki, Y; Katayama, T; Kawai, M; Mizumoto, H; Yamashita, S, 2015) |
| "Diazoxide is an effective and usually safe medication to treat this type and other types of neonatal HI." | 1.42 | Liver injury may increase the risk of diazoxide toxicity: a case report. ( Garibaldi, L; Mahmood, B; Sperling, M; Tas, E, 2015) |
| "Congenital hyperinsulinism is a condition of dysregulated insulin secretion often caused by inactivating mutations of the ATP-sensitive K+ (KATP) channel in the pancreatic beta cell." | 1.35 | Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations. ( Becker, S; Ganguly, A; Hanna, C; Lin, YW; MacMullen, C; Pinney, SE; Shyng, SL; Stanley, CA; Thornton, P, 2008) |
| "Insulinomas are rare neuroendocrine tumours that are usually small and may take time to localize." | 1.35 | Continuous glucose monitoring in patients with insulinoma. ( Choudhary, P; Harrison, B; Heller, S; Munir, A; Newell-Price, J, 2008) |
| "Hypoglycemia has been documented due to growth hormone and cortisol deficiency." | 1.33 | Costello syndrome and hyperinsulinemic hypoglycemia. ( Al-Sharkawi, I; Alexander, S; Alkhayyat, H; Backer, KC; El-Sabban, F; Hussain, K; Ramadan, D, 2005) |
| "Treatment with diazoxide and chlorthiazide is highly effective, appears to be safe, and does not need to be continued lifelong." | 1.33 | Hyperinsulinism in tyrosinaemia type I. ( Baumann, U; Green, A; Kelly, DA; McKiernan, PJ; Preece, MA, 2005) |
| "Diazoxide is an agonist of the pancreatic beta-cell KATP channel and inhibits insulin secretion." | 1.33 | Ketotic hypoglycaemia in children with diazoxide responsive hyperinsulinism of infancy. ( Hussain, K, 2005) |
| "Although insulinoma is rare in the elderly and exceedingly rare in the context of type 2 diabetes, it should be given due consideration when no other exacerbating factor is found." | 1.33 | A mysterious case of normalising blood sugar: insulinoma in a long-standing diabetic patient. ( Hameed, MF; Hoyle, GE; Muir, Z, 2006) |
| "A common and well recognised feature of Turner's syndrome (partial or total monosomy X) is impaired glucose tolerance or type 2 diabetes mellitus." | 1.33 | Mosaic Turner syndrome and hyperinsulinaemic hypoglycaemia. ( Alkhayyat, H; Brusgaard, K; Christesen, HB; Hussain, K; Steer, J; Stewart, H, 2006) |
| "Hyperinsulinism was diagnosed in our Clinic." | 1.31 | Neonatal hyperinsulinemic hypoglycemia. Two case reports. ( Antoniazzi, F; Maffeis, C; Tatò, L; Zaffanello, M; Zamboni, G, 2002) |
| "The hypoglycemia was refractory to high glucose delivery rates (25 mg/kg/min), but responded to a combination of octreotide and diazoxide." | 1.31 | Transient hyperinsulinism in an asphyxiated newborn infant with hypoglycemia. ( Clark, W; O'Donovan, D, 2001) |
| "Diazoxide was without effect on tau(open) and tau(closed,fast) but decreased significantly tau(closed,slow) (24." | 1.31 | Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells. ( Carlen, PL; Pahapill, PA; Pelletier, MR; Pennefather, PS, 2000) |
| "Hypoglycemia was induced with insulin and its effects on cerebral blood flow (measured with an electromagnetic flow transducer placed on the internal maxillary artery) were studied in awake goats under control conditions and after administration of the nitric oxide synthesis inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME, 47 mg/kg)." | 1.30 | Role of nitric oxide in the effects of hypoglycemia on the cerebral circulation in awake goats. ( Diéguez, G; Fernández, N; García, JL; García-Villalón, AL; Gomez, B; Monge, L, 1997) |
| "Diazoxide treatment remains the mainstay of medical therapy in long-term management." | 1.30 | Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: a retrospective review of 77 cases and analysis of efficacy-predicting criteria. ( Brunelle, F; Czernichow, P; Nihoul-Fekete, C; Ogier de Baulny, H; Poggi-Travert, F; Rahier, J; Saudubray, JM; Touati, G, 1998) |
| "When treatment with diazoxide and somatostatin for persistent hyperinsulinaemic hypoglycaemia of infancy failed, subtotal pancreatectomy was performed on a neonate on day 41." | 1.30 | Histochemical, clinical, and in vitro beta cell responses in a neonate with persistent hyperinsulinaemic hypoglycaemia of infancy. ( Hjelm, NM; Liew, CT; Panesar, NS; Poon, CW; Wong, GW, 1998) |
| "Treatment with diazoxide is rational and effective and may be lifesaving." | 1.28 | Clinical spectrum of sulfonylurea overdose and experience with diazoxide therapy. ( Meatherall, RC; Palatnick, W; Tenenbein, M, 1991) |
| "Cardiorespiratory failure (toxicity) occurred on eight of the 11 occasions (73%) in seven infants." | 1.28 | Complications of diazoxide treatment in persistent neonatal hyperinsulinism. ( Abu-Osba, YK; Manasra, KB; Mathew, PM, 1989) |
| "Diazoxide was useful in the treatment of three patients but many side-effects were observed." | 1.28 | Hyperinsulinism in infancy. ( Chow, OK; Low, LC; Yeung, CY; Young, RT; Yu, EC, 1989) |
| "Oral diazoxide was effective in reversing the marked hypoglycaemia." | 1.27 | Reversal of pentamidine-induced hypoglycaemia with oral diazoxide. ( Fitzgerald, DB; Young, IS, 1984) |
| "Diazoxide treatment could be stopped at the age of 1 month." | 1.27 | Transient lactic acidosis and hyperalaninaemia associated with neonatal hyperinsulinaemic hypoglycaemia: the effects of dichloroacetate (DCA). ( Aynsley-Green, A; Jenkins, PA; Soltész, G; Weindling, AM, 1983) |
| "Diazoxide (10 mg/kg/d) was successful in controlling hypoglycemia for eight years and one year, respectively, without serious side effects." | 1.27 | Persistent neonatal hyperinsulinemic hypoglycemia in two siblings successfully treated with diazoxide. ( Schubiger, G; Wüthrich, C; Zuppinger, K, 1986) |
| "The third has occasional fasting hypoglycemia that is treated with diazoxide; he continues to have a seizure disorder and is mentally retarded." | 1.26 | Nesidioblastosis in children. ( Danis, RK; Garvin, PJ; Knight, J; Lewis, JE; Willman, VL, 1980) |
| "To avoid mental retardation, surgical intervention should not be considered as a last resort." | 1.26 | Near-total pancreatectomy in persistent infantile hypoglycemia. ( Moazam, F; Rodgers, BM; Rosenbloom, AL; Talbert, JL, 1982) |
| "A seven months old infant suffered from convulsions due to leucine-sensitive hypoglycaemia." | 1.26 | [Leucine-sensitive hypoglycaemia and its treatment with diazoxide (author's transl)]. ( Reich, H; Schünke, W, 1976) |
| "Islet cell adenomas are an important consideration in infants and children with hypoglycemia due to hyperinsulinism." | 1.26 | Pancreatic adenomas in infants and children: current surgical management. ( Baker, L; Bishop, HC; Gauderer, M; Stanley, CA, 1978) |
| "In five patients with islet cell tumors and fasting hypoglycemia, basal proinsulin-like component ranged from 26 to 79% of the total immunoreactive insulin." | 1.25 | Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors. ( Gorden, P; Roth, J; Sherman, B, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 199 (58.53) | 18.7374 |
| 1990's | 38 (11.18) | 18.2507 |
| 2000's | 39 (11.47) | 29.6817 |
| 2010's | 47 (13.82) | 24.3611 |
| 2020's | 17 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| McGlacken-Byrne, SM | 2 |
| Mohammad, JK | 1 |
| Conlon, N | 1 |
| Gubaeva, D | 1 |
| Siersbæk, J | 1 |
| Schou, AJ | 1 |
| Demirbilek, H | 1 |
| Dastamani, A | 2 |
| Houghton, JAL | 1 |
| Brusgaard, K | 2 |
| Melikyan, M | 1 |
| Christesen, H | 1 |
| Flanagan, SE | 6 |
| Murphy, NP | 2 |
| Shah, P | 3 |
| Vurallı, D | 1 |
| Yıldız, Y | 1 |
| Ozon, A | 1 |
| Dursun, A | 1 |
| Gönç, N | 1 |
| Tokatlı, A | 1 |
| Sivri, HS | 1 |
| Alikaşifoğlu, A | 1 |
| Aida, A | 1 |
| Noto, H | 1 |
| Laing, D | 1 |
| Walsh, E | 1 |
| Alsweiler, JM | 1 |
| Hanning, SM | 1 |
| Meyer, MP | 1 |
| Ardern, J | 1 |
| Cutfield, WS | 1 |
| Rogers, J | 1 |
| Gamble, GD | 1 |
| Chase, JG | 1 |
| Harding, JE | 1 |
| McKinlay, CJ | 1 |
| Solís-García, G | 1 |
| Yeung, T | 1 |
| Jasani, B | 1 |
| Chandran, S | 2 |
| Jaya-Bodestyne, SL | 1 |
| Rajadurai, VS | 2 |
| Saffari, SE | 1 |
| Chua, MC | 1 |
| Yap, F | 1 |
| Maines, E | 1 |
| Urru, SAM | 1 |
| Leonardi, L | 1 |
| Fancellu, E | 1 |
| Campomori, A | 1 |
| Piccoli, G | 1 |
| Maiorana, A | 1 |
| Soffiati, M | 1 |
| Franceschi, R | 1 |
| Chen, SC | 1 |
| Pintus, D | 1 |
| Yau, D | 1 |
| Aftab, S | 1 |
| Bath, L | 1 |
| Swinburne, C | 1 |
| Hunter, L | 1 |
| Giardini, A | 1 |
| Christov, G | 1 |
| Senniappan, S | 3 |
| Banerjee, I | 4 |
| Shaikh, MG | 1 |
| Davidov, AS | 1 |
| Elkon-Tamir, E | 1 |
| Haham, A | 1 |
| Shefer, G | 1 |
| Weintrob, N | 1 |
| Oren, A | 1 |
| Lebenthal, Y | 1 |
| Mandel, D | 1 |
| Eyal, O | 1 |
| Mesmar, B | 1 |
| Kristan, M | 1 |
| Satyarengga, M | 1 |
| Lamos, EM | 1 |
| Malek, R | 1 |
| Munir, KM | 1 |
| Shah, N | 1 |
| Khadilkar, A | 1 |
| Khadilkar, V | 1 |
| Lad, S | 1 |
| Madan, R | 1 |
| Mettler, T | 1 |
| Froelich, J | 1 |
| Chow, LS | 1 |
| Benner, BJM | 1 |
| Bazelmans, M | 1 |
| Huidekoper, H | 1 |
| Langeveld, M | 1 |
| Langendonk, J | 1 |
| Schoenmakers, S | 1 |
| Brar, PC | 1 |
| Heksch, R | 1 |
| Cossen, K | 1 |
| De Leon, DD | 1 |
| Kamboj, MK | 1 |
| Marks, SD | 1 |
| Marshall, BA | 1 |
| Miller, R | 1 |
| Page, L | 1 |
| Stanley, T | 1 |
| Mitchell, D | 1 |
| Thornton, P | 3 |
| Prado, LA | 1 |
| Castro, M | 1 |
| Weisz, DE | 1 |
| Jain, A | 1 |
| Belik, J | 1 |
| Bolmasova, AV | 1 |
| Melikyan, MA | 1 |
| Krylova, NA | 1 |
| Ionov, OV | 1 |
| Ryumina, II | 1 |
| Bockeria, EL | 1 |
| Pekareva, NA | 1 |
| Degtyareva, AV | 1 |
| Chen, X | 1 |
| Feng, L | 1 |
| Yao, H | 1 |
| Yang, L | 1 |
| Qin, Y | 1 |
| Nagaoka, M | 1 |
| Akaishi, M | 1 |
| Iida, K | 1 |
| Yoshida, T | 1 |
| Bourque, SL | 1 |
| Rozance, PJ | 2 |
| Hay, WW | 1 |
| Veiguela Blanco, B | 1 |
| Felechosa, MD | 1 |
| García Moreira, V | 1 |
| Reno, CM | 1 |
| Bayles, J | 1 |
| Skinner, A | 1 |
| Fisher, SJ | 1 |
| Gray, KD | 1 |
| Dudash, K | 1 |
| Escobar, C | 1 |
| Freel, C | 1 |
| Harrison, T | 1 |
| McMillan, C | 1 |
| Puia-Dumitrescu, M | 1 |
| Cotten, CM | 1 |
| Benjamin, R | 1 |
| Clark, RH | 1 |
| Benjamin, DK | 1 |
| Greenberg, RG | 1 |
| Salomon-Estebanez, M | 1 |
| Nicholson, J | 1 |
| Cosgrove, KE | 2 |
| Dunne, MJ | 3 |
| Welters, A | 1 |
| Meissner, T | 1 |
| Grulich-Henn, J | 1 |
| Fröhlich-Reiterer, E | 1 |
| Warncke, K | 1 |
| Mohnike, K | 1 |
| Blankenstein, O | 1 |
| Menzel, U | 1 |
| Datz, N | 1 |
| Bollow, E | 1 |
| Holl, RW | 1 |
| Dauriz, M | 1 |
| Maneschi, C | 1 |
| Castelli, C | 1 |
| Tomezzoli, A | 1 |
| Fuini, A | 1 |
| Landoni, L | 1 |
| Malleo, G | 1 |
| Ferdeghini, M | 1 |
| Bonora, E | 1 |
| Moghetti, P | 1 |
| Vezzosi, D | 1 |
| Guillaume, E | 1 |
| Bennet, A | 1 |
| Mouly, C | 1 |
| Hanaire, H | 1 |
| Caron, P | 1 |
| Tabarin, A | 1 |
| Goichot, B | 1 |
| Hawkes, CP | 1 |
| Ellard, S | 5 |
| McDonnell, CM | 1 |
| Martínez-Ortega, AJ | 1 |
| Mangas-Cruz, MA | 1 |
| Aliaga-Verdugo, A | 1 |
| Acosta-Delgado, D | 1 |
| Ponmani, C | 1 |
| Gannon, H | 1 |
| Hussain, K | 14 |
| Chan, O | 4 |
| Paranjape, SA | 2 |
| Horblitt, A | 2 |
| Zhu, W | 4 |
| Sherwin, RS | 4 |
| Ağladıoğlu, SY | 1 |
| Savaş Erdeve, S | 1 |
| Cetinkaya, S | 1 |
| Baş, VN | 1 |
| Peltek Kendirci, HN | 1 |
| Onder, A | 1 |
| Aycan, Z | 1 |
| Hitman, GA | 1 |
| Chong, JH | 1 |
| Agarwal, P | 1 |
| Edwards, TM | 1 |
| Spatz, DL | 1 |
| Vadász, J | 1 |
| Barta, G | 1 |
| Krasznai, G | 1 |
| Ludger, F | 1 |
| Zalatnai, A | 1 |
| Manocha, D | 1 |
| Shah, R | 1 |
| Vaidya, GN | 1 |
| Bansal, N | 1 |
| George, PS | 1 |
| Tavendale, R | 1 |
| Palmer, CN | 1 |
| McCrimmon, RJ | 2 |
| Tas, E | 1 |
| Mahmood, B | 1 |
| Garibaldi, L | 1 |
| Sperling, M | 1 |
| Shimizu, M | 1 |
| Suzuki, K | 1 |
| Tsuchida, K | 1 |
| Kojima, M | 1 |
| Hiraishi, H | 1 |
| Aso, Y | 1 |
| Yoshioka, M | 1 |
| Shibata, S | 1 |
| Uchinami, H | 1 |
| Watanabe, G | 1 |
| Miyazawa, H | 1 |
| Iida, M | 1 |
| Yoshida, M | 2 |
| Yoshioka, T | 1 |
| Nanjo, H | 1 |
| Yamamoto, Y | 1 |
| Mizumoto, H | 1 |
| Iki, Y | 1 |
| Yamashita, S | 1 |
| Kawai, M | 1 |
| Katayama, T | 1 |
| Hata, D | 1 |
| Sadeghizadeh, A | 1 |
| Hashemipour, M | 1 |
| Hosseinzadeh, M | 1 |
| Salehi, M | 1 |
| Komatsu, Y | 1 |
| Nakamura, A | 1 |
| Takihata, M | 1 |
| Inoue, Y | 1 |
| Yahagi, S | 1 |
| Tajima, K | 1 |
| Tsuchiya, H | 1 |
| Takano, T | 1 |
| Yamakawa, T | 1 |
| Miyoshi, H | 1 |
| Terauchi, Y | 1 |
| Sandoval, MA | 1 |
| Pagsisihan, D | 1 |
| Berberabe, A | 1 |
| Palugod-Lopez, EG | 1 |
| Shao, Y | 1 |
| Qu, YQ | 1 |
| Wang, XL | 1 |
| Song, ZG | 1 |
| Guo, QH | 1 |
| Dou, JT | 1 |
| Ba, JM | 1 |
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| Pinney, SE | 1 |
| MacMullen, C | 1 |
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| Lin, YW | 1 |
| Hanna, C | 1 |
| Ganguly, A | 1 |
| Shyng, SL | 3 |
| Stanley, CA | 8 |
| Narayanaswamy, V | 1 |
| Rettig, KR | 1 |
| Bhowmick, SK | 1 |
| Spanakis, E | 1 |
| Gragnoli, C | 1 |
| Radtke, MA | 1 |
| Nermoen, I | 1 |
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| Martinez-Ibanez, V | 1 |
| Gussinyer, M | 1 |
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| Abad, P | 1 |
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| Boix-Ochoa, J | 1 |
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| Chaichanwatanakul, K | 1 |
| Laohapansang, M | 1 |
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| Shepherd, RM | 1 |
| Chapman, JC | 1 |
| Swift, SM | 1 |
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| Glaser, B | 4 |
| Lindley, KJ | 2 |
| Aynsley-Green, A | 10 |
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| Hameed, MF | 1 |
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| Seppänen, M | 1 |
| Näntö-Salonen, K | 1 |
| Adzick, NS | 1 |
| Minn, H | 1 |
| Won, JG | 1 |
| Tseng, HS | 1 |
| Yang, AH | 1 |
| Tang, KT | 1 |
| Jap, TS | 1 |
| Lee, CH | 1 |
| Lin, HD | 1 |
| Burcus, N | 1 |
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| Fafoula, O | 1 |
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| Hoover, WC | 1 |
| Caldwell, RL | 1 |
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| Eugster, EA | 1 |
| Munir, A | 1 |
| Choudhary, P | 1 |
| Harrison, B | 1 |
| Heller, S | 1 |
| Newell-Price, J | 1 |
| Combs, JT | 1 |
| Grunt, JA | 1 |
| Brandt, IK | 1 |
| Ehrlich, R | 1 |
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| Bain, HW | 1 |
| Paraf, A | 2 |
| Rautureau, J | 2 |
| Texier, J | 1 |
| Wright, J | 1 |
| Abolfathi, A | 1 |
| Penman, E | 1 |
| Marks, V | 5 |
| Hallengren, B | 1 |
| Hökfelt, B | 1 |
| Knight, J | 1 |
| Garvin, PJ | 1 |
| Danis, RK | 1 |
| Lewis, JE | 1 |
| Willman, VL | 1 |
| Moazam, F | 1 |
| Rodgers, BM | 1 |
| Talbert, JL | 1 |
| Rosenbloom, AL | 3 |
| Berger, M | 1 |
| Tsotsalas, M | 1 |
| MacDonald, MJ | 1 |
| Warner, TF | 1 |
| Pellett, JR | 1 |
| Soltész, G | 5 |
| Fitzgerald, DB | 1 |
| Young, IS | 1 |
| Lyen, KR | 1 |
| Jenkins, PA | 2 |
| Hochberg, Z | 1 |
| Spindel, A | 1 |
| Guttman, H | 1 |
| Colin, AA | 1 |
| Kuroda, H | 1 |
| Tsubota, T | 1 |
| Hokaku, J | 1 |
| Goshi, K | 1 |
| Takahashi, T | 1 |
| Weindling, AM | 1 |
| Zuniga, O | 1 |
| Golden, MP | 1 |
| Sargeant, DT | 1 |
| Graham, MJ | 1 |
| Bradvica, C | 1 |
| Santiago, J | 1 |
| White, NH | 1 |
| Ventura, A | 2 |
| Canciani, M | 1 |
| Tamaro, P | 1 |
| Jeffery, WH | 1 |
| Graham, EM | 1 |
| Molnár, D | 1 |
| Pintér, A | 1 |
| Németh, A | 1 |
| Polak, JM | 1 |
| Bloom, SR | 1 |
| Gough, MH | 1 |
| Keeling, J | 1 |
| Ashcroft, SJ | 1 |
| Turner, RC | 1 |
| Baum, JD | 1 |
| Chrousos, GP | 1 |
| Wachlicht-Rodbard, H | 1 |
| Adams, AJ | 1 |
| Roth, J | 2 |
| Cornblath, M | 4 |
| Roe, TF | 2 |
| Kogut, MD | 1 |
| Santucci, S | 1 |
| Tosi, M | 1 |
| Marazzini, P | 1 |
| Barp, S | 1 |
| Bertoletti, A | 1 |
| Oliete García, F | 1 |
| Herrera Andújar, P | 1 |
| Pérez Carmona, NJ | 1 |
| Balboa de Paz, F | 1 |
| Maertens, P | 1 |
| de Geeter, B | 1 |
| Kurtz, F | 1 |
| Messer, J | 1 |
| Raber, A | 1 |
| Willard, D | 1 |
| Tintinalli, JE | 1 |
| Baker, L | 8 |
| Solomon, CG | 1 |
| Dluhy, RG | 1 |
| Yagi, M | 1 |
| Shiraiwa, K | 1 |
| Abiko, M | 1 |
| Sakuma, H | 1 |
| Hirai, S | 1 |
| Pronicka, E | 1 |
| Gruszczyńska, B | 1 |
| Woźniewicz, B | 1 |
| Cedro, A | 1 |
| Kamiński, W | 1 |
| Leśniewska, A | 1 |
| Koretz, B | 1 |
| von B Ahern, K | 1 |
| Wang, N | 1 |
| Lustig, HS | 1 |
| Greenberg, DA | 1 |
| Walker, M | 1 |
| Trajano, LR | 1 |
| Alberti, KG | 2 |
| Kendall-Taylor, P | 1 |
| Clapham, JC | 1 |
| Trail, BK | 1 |
| Hamilton, TC | 1 |
| Féliz-De Vargas Pastor, J | 1 |
| García Jiménez, I | 1 |
| Sánchez Miramón, F | 1 |
| García López, P | 1 |
| Uriel Miñana, P | 1 |
| Baldellou Vázquez, A | 1 |
| Rebaje Moise, V | 1 |
| Aparicio, L | 1 |
| Carpenter, MW | 1 |
| Schwartz, R | 1 |
| Gruppuso, PA | 1 |
| Daneman, D | 1 |
| Ehrlich, RM | 2 |
| Alter, CA | 1 |
| Katz, LE | 1 |
| Hirsch, HJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Diazoxide in Acute Hypoglycaemia[NCT01488136] | Phase 4 | 12 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Use for Diazoxide in the Initial Management of Hypoglycemia in Infants of Diabetic Mothers and Infants Large for Gestation[NCT00994149] | Phase 2/Phase 3 | 100 participants (Anticipated) | Interventional | 2009-10-31 | Not yet recruiting | ||
| Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery[NCT01841359] | Phase 4 | 22 participants (Actual) | Interventional | 2010-02-02 | Completed | ||
| A Prospective Randomized, Placebo (Saline)-Controlled, Balanced, 3-treatment Regimen Crossover Study Comparing the Effects of Prolonged (13 h) Hyperglucagonemia With Those of Acute (3 hr) Hyperglucagonemia on Energy Expenditure and Endogenous Glucose Prot[NCT02237053] | Phase 1 | 6 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01841359)
Timeframe: During 8 week period of participation, V1-V2 (baseline CGM data over 3 days); V3-V4 (CGM data during treatment with three times per day (TID) pramlintide over 3 days)
| Intervention | mg/dL (Mean) |
|---|---|
| Baseline (Prior to Treatment With Pramlintide) CGM #1 | 172 |
| Pramlintide CGM #2 | 188 |
(NCT01841359)
Timeframe: During 8 week period of participation, V1-V2 (baseline CGM data over 3 days); V3-V4 (CGM data during treatment with TID pramlintide over 3 days)
| Intervention | mg/dL (Mean) |
|---|---|
| Baseline (Prior to Treatment With Pramlintide) CGM #1 | 54 |
| Pramlintide CGM #2 | 56.6 |
Dumping score was calculated using changes in pulse and hematocrit. Higher scores indicate more severe dumping. Scores ranged from -196 to 186. (NCT01841359)
Timeframe: Levels assessed on the two days of mixed meal testing: the first occurring at baseline; and the second following 8 weeks of treatment with pramlintide.
| Intervention | dumping score (Mean) |
|---|---|
| Baseline (Prior to Pramlintide Treatment) Mixed Meal #1 | 28.89 |
| Pramlintide - Mixed Meal #2 | 72.04 |
Assessment of clinical response to pramlintide treatment, as indicated by paired comparison of the frequency of glucose values under 70 mg/dl (expressed as percentage of time) assessed by continuous glucose monitoring. (NCT01841359)
Timeframe: During 8 week period of participation, V1-V2 (baseline CGM data over 3 days); V3-V4 (CGM data during treatment with TID pramlintide over 3 days)
| Intervention | percent time sensor glucose less than 70 (Mean) |
|---|---|
| Baseline (Prior to Treatment With Pramlintide) CGM #1 | 8.85 |
| Pramlintide CGM #2 | 5.60 |
(NCT01841359)
Timeframe: Levels assessed on the two days of mixed meal testing: the first occurring at baseline; and the second following 8 weeks of treatment with pramlintide.
| Intervention | mg/dL (Mean) |
|---|---|
| Baseline (Prior to Pramlintide Treatment) Mixed Meal #1 | 67.18 |
| Pramlintide - Mixed Meal #2 | 69.9 |
(NCT01841359)
Timeframe: During 8 week period of participation, V1-V2 (baseline CGM data over 3 days); V3-V4 (CGM data during treatment with TID pramlintide over 3 days)
| Intervention | days (Mean) |
|---|---|
| Baseline (Prior to Treatment With Pramlintide) CGM #1 | 1.31 |
| Pramlintide CGM #2 | 0.56 |
(NCT01841359)
Timeframe: Assessed on the two days of mixed meal testing: the first occurring at baseline; and the second following 8 weeks of treatment with pramlintide.
| Intervention | number of participants (Number) |
|---|---|
| Baseline (Prior to Pramlintide Treatment) Mixed Meal #1 | 6 |
| Pramlintide - Mixed Meal #2 | 4 |
"Baseline and post-treatment with pramlintide mixed meal testing plasma glucose values, area under the curve (AUC), calculated with the trapezoidal method.~Plasma glucose was measured at timepoints (minutes): -5 (baseline), 10 minutes, 20 minutes, 30 minutes, 60 minutes, 90 minutes, 120 minutes." (NCT01841359)
Timeframe: Levels assessed on the two days of mixed meal testing: the first occurring at baseline; and the second following 8 weeks of treatment with pramlintide.
| Intervention | mg*min/dL (Geometric Mean) |
|---|---|
| Baseline (Prior to Pramlintide Treatment) Mixed Meal #1 | 2828 |
| Pramlintide - Mixed Meal #2 | 2893 |
"Pre- and post-treatment mixed meal testing plasma insulin levels area under the curve (AUC) was calculated with the trapezoidal method.~Plasma insulin was measured at timepoints (minutes): -5 (baseline), 10 minutes, 20 minutes, 30 minutes, 60 minutes, 90 minutes, 120 minutes." (NCT01841359)
Timeframe: Levels assessed on the two days of mixed meal testing: the first occurring at baseline; and the second following 8 weeks of treatment with pramlintide.
| Intervention | uIU*min/mL (Geometric Mean) |
|---|---|
| Baseline (Prior to Pramlintide Treatment) Mixed Meal #1 | 3393 |
| Pramlintide - Mixed Meal #2 | 3501 |
Satiety was analyzed using a visual analogue scale (1, very hungry to 10, not hungry), administered 120 minutes following ingestion of mixed meal. (NCT01841359)
Timeframe: Levels assessed on the two days of mixed meal testing at the 120 min time point: the first occurring at baseline (prior to treatment with pramlintide), and the second following 8 weeks of treatment with pramlintide.
| Intervention | satiety score (Mean) |
|---|---|
| Baseline (Prior to Pramlintide Treatment) Mixed Meal #1 | 4.57 |
| Pramlintide - Mixed Meal #2 | 5.43 |
(NCT01841359)
Timeframe: Assessed on the two days of mixed meal testing: the first occurring at baseline; and the second following 8 weeks of treatment with pramlintide.
| Intervention | minutes (Mean) |
|---|---|
| Baseline (Prior to Pramlintide Treatment) Mixed Meal #1 | 64.29 |
| Pramlintide - Mixed Meal #2 | 66.43 |
33 reviews available for diazoxide and Fasting Hypoglycemia
| Article | Year |
|---|---|
Drug-induced hyperinsulinemic hypoglycemia: An update on pathophysiology and treatment.
Topics: Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Insulin Secretion | 2023 |
Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis.
Topics: Antihypertensive Agents; Diazoxide; Humans; Hyperinsulinism; Hypertrichosis; Hypoglycemia; Treatment | 2021 |
Autoimmune hypoglycemia due to anti-insulin antibodies.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Autoimmune Dis | 2018 |
Therapies and outcomes of congenital hyperinsulinism-induced hypoglycaemia.
Topics: Antihypertensive Agents; Congenital Hyperinsulinism; Diazoxide; Gastrointestinal Agents; Glucagon; H | 2019 |
Update on neonatal hypoglycemia.
Topics: Biosensing Techniques; Blood Glucose; Developmental Disabilities; Diazoxide; Diuretics; Female; Gluc | 2014 |
Congenital hyperinsulinism: exclusive human milk and breastfeeding.
Topics: Breast Feeding; Congenital Hyperinsulinism; Diazoxide; Female; Fluid Therapy; Food, Fortified; Gastr | 2014 |
Octreotide's role in the management of sulfonylurea-induced hypoglycemia.
Topics: Animals; Diazoxide; Diuretics; Gastrointestinal Agents; Glucagon; Humans; Hypoglycemia; Hypoglycemic | 2010 |
When it is more than transient neonatal hypoglycemia: hyperinsulinemia--a case study challenge.
Topics: Blood Glucose; Brain Damage, Chronic; Diagnosis, Differential; Diazoxide; Enteral Nutrition; Female; | 2001 |
[PHHI (persistent hyperinsulinemic hypoglycemia of infancy)].
Topics: Animals; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Diagnosis, Differential; Diazo | 2002 |
Medications used in the treatment of hypoglycemia due to congenital hyperinsulinism of infancy (HI).
Topics: Congenital Hyperinsulinism; Diazoxide; Gastrointestinal Agents; Glucagon; Humans; Hypoglycemia; Infa | 2004 |
Hyperinsulinism in infancy and childhood.
Topics: Beckwith-Wiedemann Syndrome; Blood Glucose; Child, Preschool; Diazoxide; Erythroblastosis, Fetal; Fe | 1984 |
Hypoglycaemia in infancy and childhood.
Topics: Blood Glucose; Child; Child, Preschool; Diazoxide; Fasting; Glycogen Storage Disease Type I; Humans; | 1984 |
Islet cell tumors.
Topics: Adenoma, Islet Cell; Diazoxide; Gastrinoma; Humans; Hypoglycemia; Insulinoma; Octreotide; Pancreatic | 1997 |
[Persistent hyperinsulinemic hypoglycemia of infancy (PHHI)].
Topics: Adenosine Triphosphate; Diazoxide; Glycosyltransferases; GTP-Binding Proteins; Humans; Hyperinsulini | 1997 |
Persistent hyperinsulinemic hypoglycemia of infancy: long-term results.
Topics: Adolescent; Adult; Child; Child, Preschool; Diazoxide; Dietary Proteins; Female; Hormones; Humans; H | 1998 |
[Persistent hyperinsulinemic hypoglycemia in the newborn and infants].
Topics: Diazoxide; Diuretics; Genetic Counseling; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, New | 1998 |
Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases.
Topics: Age of Onset; Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Genetic Heterogeneity; Gluc | 2002 |
Persistent hyperinsulinaemic hypoglycaemia.
Topics: Diazoxide; Diuretics; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Pancreatectomy; Progno | 2002 |
Diagnosis and medical management of insulinomas.
Topics: Adenoma, Islet Cell; Angiography; Antineoplastic Agents; Benzothiadiazines; Blood Glucose; C-Peptide | 1979 |
[Juvenile endocrine hypoglycemia].
Topics: Adenoma; Child, Preschool; Diazoxide; Folic Acid; Fructose-1,6-Diphosphatase Deficiency; Gluconeogen | 1979 |
[Hypoglycemia in childhood. Nosographic classification and diagnostic and therapeutic criteria].
Topics: Diazoxide; Glucagon; Glucose; Humans; Hydrocortisone; Hypoglycemia; Infant; Infant, Newborn | 1979 |
Hyperinsulinism in infants and children: diagnosis and therapy.
Topics: Adult; Blood Glucose; Child; Child, Preschool; Diazoxide; Fatty Acids, Nonesterified; Humans; Hydrox | 1976 |
Selected tests of carbohydrate metabolism.
Topics: Adolescent; Adult; Blood Glucose; Carbohydrate Metabolism; Child; Clinical Laboratory Techniques; Di | 1976 |
Management of insuloma patients with refractory hypoglycemia.
Topics: Animals; Diazoxide; Dog Diseases; Dogs; Glucocorticoids; Hypoglycemia; Insulinoma; Prognosis; Somato | 1990 |
The hepatic glycogenoses.
Topics: Biopsy; Child; Chlorothiazide; Diazoxide; Female; Glucosidases; Glucosyltransferases; Glycogen Stora | 1971 |
[Hypoglycemia. 3].
Topics: Animals; Arginine; Biguanides; Diazoxide; Dicumarol; Drug Synergism; Ethanol; Glucagon; Glucocortico | 1970 |
Hypoglycemia and the central nervous system.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Child, Preschool; Diazoxide; Diet Therapy; Epin | 1967 |
[Hypoglycemia and its countermeasures].
Topics: Acute Disease; Adenoma, Islet Cell; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Animals; Bloo | 1969 |
Chemotherapeutic management of the hormone-secreting endocrine malignancies.
Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Aminoglutethimide; Aniline Compounds; Antibiotics, Ant | 1972 |
Hypoglycemia in infancy and childhood. II.
Topics: Adrenal Cortex Hormones; Adrenal Gland Diseases; Amino Acids; Carbohydrate Metabolism, Inborn Errors | 1973 |
Diazoxide and the treatment of hypoglycemia: an historical review.
Topics: Animals; Antihypertensive Agents; Diazoxide; Dogs; Drug Synergism; Glucose; Humans; Hyperglycemia; H | 1968 |
[The hypoglycemia syndrome].
Topics: Alloxan; Angiography; Antibiotics, Antineoplastic; Blood Glucose; Diagnosis, Differential; Diazoxide | 1970 |
[Pharmacodynamical and clinical experimental studies of the treatment of hypoglycemia by diazoxide].
Topics: Adult; Animals; Child; Diazoxide; Dogs; Humans; Hypoglycemia; Infant | 1967 |
3 trials available for diazoxide and Fasting Hypoglycemia
| Article | Year |
|---|---|
Oral diazoxide versus placebo for severe or recurrent neonatal hypoglycaemia: Neonatal Glucose Care Optimisation (NeoGluCO) study - a randomised controlled trial.
Topics: Blood Glucose; Diazoxide; Double-Blind Method; Female; Fetal Diseases; Glucose; Humans; Hypoglycemia | 2022 |
Diazoxide improves hormonal counterregulatory responses to acute hypoglycemia in long-standing type 1 diabetes.
Topics: Adolescent; Adult; Diabetes Mellitus, Type 1; Diazoxide; Double-Blind Method; Female; Genotype; Huma | 2015 |
Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control.
Topics: Adult; Antihypertensive Agents; Autoimmunity; Blood Glucose; Body Weight; Circadian Rhythm; Diabetes | 2010 |
304 other studies available for diazoxide and Fasting Hypoglycemia
| Article | Year |
|---|---|
Clinical and genetic heterogeneity of HNF4A/HNF1A mutations in a multicentre paediatric cohort with hyperinsulinaemic hypoglycaemia.
Topics: Adolescent; Birth Weight; Child; Child, Preschool; Cohort Studies; Diabetes Mellitus, Type 1; Diabet | 2022 |
Hyperinsulinism May Be Underreported in Hypoglycemic Patients with Phosphomannomutase 2 Deficiency
Topics: Congenital Disorders of Glycosylation; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Hypoglycemi | 2022 |
Diagnosis and Treatment Course of Insulinoma Presenting as Hypoglycemia Unawareness Using a Factory-Calibrated Continuous Glucose Monitoring System.
Topics: Adult; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Complications; Diazoxide; Humans; Hype | 2022 |
Does the use of diazoxide for hyperinsulinaemic hypoglycaemia increase the risk of necrotising enterocolitis in neonates?
Topics: Diazoxide; Enterocolitis, Necrotizing; Female; Fetal Diseases; Humans; Hypoglycemia; Infant, Newborn | 2023 |
Watchful waiting versus pharmacological management of small-for-gestational-age infants with hyperinsulinemic hypoglycemia.
Topics: Awareness; Cognition; Diazoxide; Fasting; Humans; Hyperinsulinism; Hypoglycemia; Infant; Watchful Wa | 2023 |
Diazoxide-induced pulmonary hypertension in hyperinsulinaemic hypoglycaemia: Recommendations from a multicentre study in the United Kingdom.
Topics: Congenital Hyperinsulinism; Diazoxide; Echocardiography; Female; Gestational Age; Humans; Hypertensi | 2019 |
Higher C-peptide levels and glucose requirements may identify neonates with transient hyperinsulinism hypoglycemia who will benefit from diazoxide treatment.
Topics: Adult; Blood Glucose; C-Peptide; Case-Control Studies; Diazoxide; Female; Gestational Age; Humans; H | 2020 |
The use of diazoxide in the management of spontaneous hypoglycemia in patients with ESRD.
Topics: Aged; Diazoxide; Female; Humans; Hypertension, Renal; Hypoglycemia; Kidney Failure, Chronic; Male; M | 2020 |
Rare association of Beckwith-Wiedemann syndrome with Hirschsprung's disease in an infant with hypoglycemia.
Topics: Beckwith-Wiedemann Syndrome; Combined Modality Therapy; Diazoxide; Female; Hirschsprung Disease; Hum | 2020 |
Changing Insulinoma Management Due to Incidentally Discovered Metastasis: A Case Report.
Topics: Ablation Techniques; Bone Neoplasms; Diagnosis, Differential; Diazoxide; Endosonography; Female; Hum | 2020 |
Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome.
Topics: Adult; Diazoxide; Diet, Carbohydrate Loading; Directive Counseling; Female; Humans; Hyperammonemia; | 2020 |
Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism.
Topics: Child; Child, Preschool; Diazoxide; Disease Management; Female; Humans; Hyperinsulinism; Hypoglycemi | 2020 |
Necrotising enterocolitis in newborns receiving diazoxide.
Topics: Canada; Correlation of Data; Diazoxide; Enterocolitis, Necrotizing; Female; Gastrointestinal Tract; | 2021 |
[Transient hyperinsulinism in neonates].
Topics: Diazoxide; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Insulin | 2020 |
Diazoxide toxicity with hypoglycemia in infants with trisomy 13.
Topics: Blood Glucose; Diazoxide; Humans; Hypoglycemia; Infant; Trisomy 13 Syndrome | 2021 |
50 Years Ago in The Journal of Pediatrics: Diazoxide Treatment for Idiopathic Hypoglycemia of Infancy.
Topics: Blood Glucose; Diazoxide; Female; History, 20th Century; Humans; Hypoglycemia; Infant; Male; Pediatr | 2017 |
Glibenclamide Prevents Hypoglycemia-Induced Fatal Cardiac Arrhythmias in Rats.
Topics: Animals; Arrhythmias, Cardiac; Diazoxide; Glyburide; Heart Rate; Hypoglycemia; Insulin; Male; Random | 2018 |
Prevalence and safety of diazoxide in the neonatal intensive care unit.
Topics: Diazoxide; Drug Utilization; Female; Gestational Age; Humans; Hypoglycemia; Infant, Newborn; Intensi | 2018 |
Characterization of diabetes following pancreatic surgery in patients with congenital hyperinsulinism.
Topics: Adolescent; Blood Glucose; C-Peptide; Child; Child, Preschool; Congenital Hyperinsulinism; Diabetes | 2018 |
A Case Report of Insulinoma Relapse on Background Nesidioblastosis: A Rare Cause of Adult Hypoglycemia.
Topics: Diazoxide; Female; Humans; Hypoglycemia; Insulinoma; Middle Aged; Neoplasm Recurrence, Local; Nesidi | 2019 |
Medical therapy in patients with endogenous hypoglycaemia: Is euglycaemia achievable?
Topics: Adult; Aged; Blood Glucose; Blood Glucose Self-Monitoring; Diazoxide; Female; Glucocorticoids; Human | 2019 |
Treatment: symptomatic treatment of hypoglycaemia.
Topics: Antineoplastic Agents; Blood Glucose; Diazoxide; Everolimus; Humans; Hypoglycemia; Insulinoma; Octre | 2013 |
The evolving course of HNF4A hyperinsulinaemic hypoglycaemia--a case series.
Topics: Age of Onset; Antihypertensive Agents; Birth Weight; Blood Glucose; Child; Child, Preschool; Congeni | 2014 |
[Hirata's disease: report of a case].
Topics: Aged, 80 and over; Asian People; Autoimmune Diseases; Diazoxide; Drug Substitution; Edema; HLA-D Ant | 2014 |
Paradoxical hypoglycaemia associated with diazoxide therapy for hyperinsulinaemic hypoglycaemia.
Topics: Congenital Hyperinsulinism; Diazoxide; Female; Glucagon; Glucose; Humans; Hypoglycemia; Infant; Octr | 2013 |
Lactate-induced release of GABA in the ventromedial hypothalamus contributes to counterregulatory failure in recurrent hypoglycemia and diabetes.
Topics: Animals; Bicuculline; Coumaric Acids; Diabetes Mellitus, Experimental; Diazoxide; GABA Antagonists; | 2013 |
Hyperinsulinemic hypoglycemia: experience in a series of 17 cases.
Topics: Child; Child, Preschool; Developmental Disabilities; Diazoxide; Epilepsy; Female; Humans; Hyperinsul | 2013 |
The variable faces of monogenic diabetes.
Topics: Antihypertensive Agents; Congenital Hyperinsulinism; Diazoxide; Female; Hepatocyte Nuclear Factor 4; | 2014 |
Delayed presentation of prolonged hyperinsulinaemic hypoglycaemia in a preterm small-for-gestational age neonate.
Topics: Blood Glucose; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Infant, Sm | 2013 |
[Insulin-like growth factor-II secreting prostate tumour causing severe hypoglycaemi].
Topics: Adenocarcinoma; Aged, 80 and over; Diazoxide; Fatal Outcome; Glucose; Humans; Hypoglycemia; Immunohi | 2014 |
Refractory hypoglycaemia in patient with gastric outlet obstruction.
Topics: Aged; Angiography; Diazoxide; Endosonography; Gastric Bypass; Gastric Outlet Obstruction; Glucose; H | 2015 |
Liver injury may increase the risk of diazoxide toxicity: a case report.
Topics: Albumins; Blood Glucose; Chemical and Drug Induced Liver Injury; Diazoxide; Heart Failure; Humans; H | 2015 |
Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide.
Topics: Antihypertensive Agents; Biomarkers, Tumor; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Dia | 2015 |
The transformation of a nonfunctioning islet cell tumor of the pancreas into a proinsulinoma under conditions of lung metastasis.
Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Is | 2015 |
Fetal Erythroblastosis May Be an Indicator of Neonatal Transient Hyperinsulinism.
Topics: Apgar Score; Birth Weight; Diazoxide; Erythroblastosis, Fetal; Erythrocyte Count; Female; Gestationa | 2015 |
Genotype and phenotype correlations in Iranian patients with hyperinsulinaemic hypoglycaemia.
Topics: Cohort Studies; Cross-Sectional Studies; Diazoxide; DNA Mutational Analysis; Female; Gene Expression | 2015 |
Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Diazoxide; Drug Monitoring; Drug Resistance; Edema | 2016 |
A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma.
Topics: Biopsy; Blood Glucose; C-Peptide; Carcinoma, Neuroendocrine; Diazoxide; Humans; Hyperinsulinism; Hyp | 2016 |
Malignant insulinoma: Report of 6 patients and literature review.
Topics: Adult; Diazoxide; Diuretics; Female; Humans; Hypoglycemia; Insulinoma; Liver Neoplasms; Male; Middle | 2016 |
Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Animals; ATP-Binding Cassette Transporters; C | 2008 |
A lethargic neonate and an infant with seizure.
Topics: Blood Glucose; Congenital Hyperinsulinism; Diazoxide; Glucagon; Glucose; Humans; Hypoglycemia; Infan | 2010 |
Successful medical management of status post-Roux-en-Y-gastric-bypass hyperinsulinemic hypoglycemia.
Topics: Antihypertensive Agents; Diazoxide; Female; Gastric Bypass; Humans; Hyperinsulinism; Hypoglycemia; M | 2009 |
Hyperinsulinemic hypoglycemia evolving to gestational diabetes and diabetes mellitus in a family carrying the inactivating ABCC8 E1506K mutation.
Topics: Adult; ATP-Binding Cassette Transporters; Child; Congenital Hyperinsulinism; Diabetes Mellitus; Diab | 2010 |
Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations.
Topics: Adolescent; Child; Child, Preschool; Cohort Studies; Congenital Hyperinsulinism; Diazoxide; Female; | 2010 |
Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia.
Topics: Analysis of Variance; Animals; Bicuculline; Blood Glucose; Catheters, Indwelling; Diazoxide; Epineph | 2010 |
Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Cohort Studies; Consanguinity; Diazoxide; Diuretics; Female; Genom | 2011 |
Interactive medical case. Lying low.
Topics: Aged, 80 and over; Confusion; Diazoxide; Dizziness; Female; Humans; Hypoglycemia; Insulinoma; Magnet | 2011 |
The diagnosis was in her birthday party!
Topics: Aged, 80 and over; Blood Glucose; C-Peptide; Confusion; Diazoxide; Epilepsy, Tonic-Clonic; Female; H | 2012 |
Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide.
Topics: Diagnosis, Differential; Diazoxide; Ductus Arteriosus, Patent; Humans; Hyperinsulinism; Hypertension | 2011 |
US-guided ethanol ablation of insulinomas: a new treatment option.
Topics: Ablation Techniques; Adult; Aged; Aged, 80 and over; Blood Glucose; Diazoxide; Endosonography; Ethan | 2012 |
Diazoxide for the treatment of hypoglycaemic dumping syndrome.
Topics: Aged; Aged, 80 and over; Diazoxide; Dumping Syndrome; Esophageal Achalasia; Female; Humans; Hypoglyc | 2013 |
Neonatal hyperinsulinism secondary to maternal intake of high-sugar drinks.
Topics: Antihypertensive Agents; Carbonated Beverages; Diazoxide; Female; Glucose; Humans; Hyperinsulinism; | 2011 |
Severe hypoglycemia secondary to methimazole-induced insulin autoimmune syndrome in a 16 year old African-American male.
Topics: Adolescent; Antithyroid Agents; Autoantibodies; Autoimmune Diseases; Black or African American; Diaz | 2012 |
Echocardiography monitoring for diazoxide induced pericardial effusion.
Topics: Administration, Oral; Child, Preschool; Diazoxide; Echocardiography; Humans; Hypoglycemia; Male; Mon | 2012 |
Autonomic dysfunction of glucose homoeostasis in congenital central hypoventilation syndrome.
Topics: Autoimmune Diseases; Cesarean Section; Diazoxide; Female; Homeodomain Proteins; Humans; Hypoglycemia | 2013 |
Clinical and molecular characterisation of hyperinsulinaemic hypoglycaemia in infants born small-for-gestational age.
Topics: Antihypertensive Agents; ATP-Binding Cassette Transporters; Blood Glucose; Diazoxide; Gestational Ag | 2013 |
Neonatal hyperinsulinemic hypoglycemia. Two case reports.
Topics: Asphyxia Neonatorum; Blood Glucose; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newbor | 2002 |
Pancreatectomy extension in persistent hyperinsulinaemic hypoglycaemia: a new strategy.
Topics: Adenoma, Islet Cell; Algorithms; Child; Child, Preschool; Diazoxide; Humans; Hyperinsulinism; Hypogl | 2002 |
Persistent hyperinsulinemic hypoglycemia of infancy: experience at Siriraj Hospital.
Topics: Blood Glucose; Diazoxide; Drug Therapy, Combination; Female; Glucagon; Glucose; Hospitals, Universit | 2002 |
Uncontrolled insulin secretion from a childhood pancreatic beta-cell adenoma is not due to the functional loss of ATP-sensitive potassium channels.
Topics: Adenoma, Islet Cell; Adenosine Triphosphate; Antihypertensive Agents; Child; Chromosomes, Human, Pai | 2002 |
Persistent hyperinsulinaemic hypoglycaemia of infancy: case report.
Topics: Anti-Inflammatory Agents; Blood Glucose; Consanguinity; Diazoxide; Epilepsy; Glucagon; Humans; Hyper | 2002 |
Persistent hyperinsulinemic hypoglycaemia followed as benign infantile convulsion.
Topics: Diazoxide; Electroencephalography; Epilepsy, Benign Neonatal; Glucose; Humans; Hyperinsulinism; Hypo | 2003 |
DRUG THERAPY IN LEUCINE-SENSITIVE HYPOGLYCEMIA.
Topics: Antihypertensive Agents; Benzothiadiazines; Child; Diazoxide; Dietary Carbohydrates; Dietary Protein | 1964 |
[INSULOMA TREATED WITH DIAZOXIDE].
Topics: Adenoma, Islet Cell; Antihypertensive Agents; Chlorthalidone; Diabetes Mellitus; Diazoxide; Geriatri | 1965 |
CONTROL OF HYPOGLYCAEMIA WITH DIAZOXIDE AND HUMAN GROWTH HORMONE.
Topics: Adenoma, Islet Cell; Antihypertensive Agents; Bendroflumethiazide; Blood Chemical Analysis; Blood Gl | 1965 |
Hyperinsulinaemic hypoglycaemia in preterm neonates.
Topics: Birth Weight; Chlorothiazide; Diazoxide; Diuretics; Female; Glucose; Humans; Hyperinsulinism; Hypogl | 2004 |
Trimethoprim-sulfamethoxazole induced prolonged hypoglycemia in an infant with MHC class II deficiency: diazoxide as a treatment option.
Topics: Blood Glucose; C-Peptide; Diazoxide; Drug Administration Schedule; Female; Gene Expression; Genes, M | 2003 |
Severe transient neonatal hyperinsulinism associated with hyperlactataemia in non-asphyxiated infants.
Topics: Acidosis; Age of Onset; Blood Glucose; C-Peptide; Chlorothiazide; Diazoxide; Diuretics; Fasting; Fat | 2004 |
Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans.
Topics: Adult; Diazoxide; Female; Glucagon; Growth Hormone; Humans; Hydrocortisone; Hypoglycemia; Insulin; I | 2005 |
Ketotic hypoglycaemia in children with diazoxide responsive hyperinsulinism of infancy.
Topics: Congenital Hyperinsulinism; Diazoxide; Humans; Hypoglycemia; Infant, Newborn; Insulin Antagonists; K | 2005 |
Hyperinsulinism in tyrosinaemia type I.
Topics: Blood Glucose; C-Peptide; Chlorothiazide; Diazoxide; Diuretics; Humans; Hyperinsulinism; Hypoglycemi | 2005 |
Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia.
Topics: Adult; Aged; Diazoxide; Diet Therapy; Dumping Syndrome; Female; Gastric Bypass; Humans; Hyperplasia; | 2005 |
[Severe neonatal hypoglycemia due to pancreatic nesidioblastosis. Methods of diagnosis and treatment].
Topics: Blood Glucose; Diagnosis, Differential; Diazoxide; Enteral Nutrition; Follow-Up Studies; Humans; Hyp | 1977 |
Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats.
Topics: Animals; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Carbonates; Cyclic S-Oxides; Diazox | 2005 |
Costello syndrome and hyperinsulinemic hypoglycemia.
Topics: Abnormalities, Multiple; Diazoxide; Fatal Outcome; Female; Humans; Hyperinsulinism; Hypoglycemia; In | 2005 |
Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism.
Topics: Antihypertensive Agents; Calcium; Case-Control Studies; Diazoxide; Enteral Nutrition; Fasting; Femal | 2006 |
A rare case of adult-onset nesidioblastosis treated successfully with diazoxide.
Topics: Angiography; Blood Glucose; Diagnosis, Differential; Diazoxide; Humans; Hyperinsulinism; Hypoglycemi | 2006 |
A mysterious case of normalising blood sugar: insulinoma in a long-standing diabetic patient.
Topics: Aged; Diabetes Mellitus, Type 2; Diazoxide; Female; Humans; Hypoglycemia; Insulinoma; Vasodilator Ag | 2006 |
The diagnosis of ectopic focal hyperinsulinism of infancy with [18F]-dopa positron emission tomography.
Topics: Chlorothiazide; Cholecystectomy; Congenital Hyperinsulinism; Diazoxide; Fluorine Radioisotopes; Huma | 2006 |
Clinical features and morphological characterization of 10 patients with noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS).
Topics: Adult; Aged; Amyloid; Antigens, Neoplasm; Biomarkers; Biomarkers, Tumor; C-Peptide; Cell Proliferati | 2006 |
Prolonged hyperinsulinaemic hypoglycaemia in newborns with intrauterine growth retardation.
Topics: Chlorothiazide; Diazoxide; Fetal Growth Retardation; Humans; Hyperinsulinism; Hypoglycemia; Hypoglyc | 2006 |
ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia.
Topics: Animals; Blood Glucose; Diazoxide; Epinephrine; gamma-Aminobutyric Acid; Glucagon; Glucose Clamp Tec | 2007 |
Mosaic Turner syndrome and hyperinsulinaemic hypoglycaemia.
Topics: Chromosome Aberrations; Chromosomes, Human, X; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglyce | 2006 |
Development of pulmonary hypertension in an infant treated with diazoxide.
Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hypertension, Pulmonary; Hypoglycemia; Hypoglycemic Agen | 2007 |
Continuous glucose monitoring in patients with insulinoma.
Topics: Adult; Aged; Antihypertensive Agents; Antineoplastic Agents, Hormonal; Blood Glucose; Diazoxide; Fem | 2008 |
Hematologic reactions to diazoxide.
Topics: Adolescent; Agranulocytosis; Diazoxide; Female; Humans; Hypoglycemia; Infant; Thrombocytopenia | 1967 |
Comment on management of hypoglycemia.
Topics: Diazoxide; Humans; Hypoglycemia; Leucine; Pancreatectomy | 1967 |
[Hypoglycemia and primary cancer of the liver. Hormonal titers. Action of diazoxide].
Topics: Adult; Diazoxide; Glucagon; Growth Hormone; Humans; Hypoglycemia; Insulin; Liver Cirrhosis; Liver Ne | 1967 |
Pancreatic somatostatinoma presenting with hypoglycaemia.
Topics: Adenocarcinoma; Adult; Chlorothiazide; Diazoxide; Female; Fluorouracil; Humans; Hypoglycemia; Pancre | 1980 |
Increase of serum androgens during diazoxide treatment.
Topics: Adult; Androgens; Diazoxide; Female; Hirsutism; Humans; Hypoglycemia | 1984 |
Nesidioblastosis in children.
Topics: Adenoma, Islet Cell; Child, Preschool; Diazoxide; Female; Glucagon; Glucose; Humans; Hyperinsulinism | 1980 |
Near-total pancreatectomy in persistent infantile hypoglycemia.
Topics: Adenoma; Adenoma, Islet Cell; Diazoxide; Female; Humans; Hyperplasia; Hypoglycemia; Infant; Infant, | 1982 |
[Therapy of hypoglycemia in the adult].
Topics: Adenoma, Islet Cell; Adult; Diazoxide; Glucagon; Glucose; Humans; Hypoglycemia; Injections, Intraven | 1983 |
Increased mitochondrial glycerol phosphate dehydrogenase activity in insulinomas of two hypoglycemic infants.
Topics: Adenoma, Islet Cell; Diazoxide; Female; Glycerolphosphate Dehydrogenase; Humans; Hypoglycemia; Infan | 1983 |
Reversal of pentamidine-induced hypoglycaemia with oral diazoxide.
Topics: Adult; Amidines; Blood Glucose; Diazoxide; Humans; Hypoglycemia; Insulin; Male; Middle Aged; Pentami | 1984 |
[Hypokalemia caused by hyperinsulinemia in infancy and childhood (based on 18 cases)].
Topics: Blood Glucose; Child; Child, Preschool; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant; In | 1984 |
Hyperinsulinaemic hypoglycaemia in infancy and childhood: a practical approach to diagnosis and medical treatment based on experience of 18 cases.
Topics: Blood Glucose; Child; Diazoxide; Female; Glucose; Glucose Tolerance Test; Glycerol; Humans; Hyperins | 1984 |
Leucine-induced hypoglycemia in a family: effect of diphenylhydantoin, oxprenolol, and diazoxide.
Topics: Adult; Child; Child, Preschool; Diazoxide; Female; Genes, Dominant; Humans; Hypoglycemia; Infant; Le | 1984 |
[Infant idiopathic hypoglycemia treated successfully with diazoxide].
Topics: Diazoxide; Humans; Hypoglycemia; Infant; Male | 1983 |
Transient lactic acidosis and hyperalaninaemia associated with neonatal hyperinsulinaemic hypoglycaemia: the effects of dichloroacetate (DCA).
Topics: Acetates; Acidosis; Alanine; Diazoxide; Dichloroacetic Acid; Humans; Hypoglycemia; Infant; Infant, N | 1983 |
Persistent leucine sensitivity following partial pancreatectomy and diazoxide treatment. Therapeutic response.
Topics: Child, Preschool; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Leucine; Pancreatectomy; | 1983 |
Efficacy of diazoxide in preventing hypoglycemia in a child affected by hypopituitary dwarfism.
Topics: Blood Glucose; Child, Preschool; Diazoxide; Dwarfism, Pituitary; Growth Hormone; Humans; Hypoglycemi | 1983 |
Treatment of chlorpropamide overdose with diazoxide.
Topics: Adolescent; Chlorpropamide; Diazoxide; Humans; Hypoglycemia; Male | 1983 |
Hyperinsulinism.
Topics: Amino Acids, Branched-Chain; B-Lymphocytes; Blood Glucose; Child, Preschool; Diazoxide; Humans; Hype | 1980 |
Nesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia.
Topics: Diazoxide; Female; Glucose; Humans; Hyperinsulinism; Hypoglycemia; In Vitro Techniques; Infant, Newb | 1981 |
Increased 125I-insulin receptor binding to erythrocytes of hypoglycemic infants and children.
Topics: Adolescent; Adult; Blood Glucose; Child, Preschool; Diazoxide; Erythrocytes; Female; Glycogen Storag | 1981 |
Idiopathic leucine-sensitive hypoglycemia syndrome: insulin and glucagon responses and effects of diazoxide.
Topics: Arginine; Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Glucagon; Humans; Hypoglycemia; | 1982 |
[Long-term diazoxide therapy of the Beckwith-Wiedemann syndrome with persistent hypoglycemia].
Topics: Beckwith-Wiedemann Syndrome; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant | 1982 |
[Hyperinsulinism probably caused by diffuse pancreatic hyperplasia].
Topics: Child, Preschool; Diazoxide; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; Male; Pancreas; Psy | 1980 |
[Long-term diazoxide therapy in recurrent leucine-sensitive hypoglycemia (author's transl)].
Topics: Child, Preschool; Diazoxide; Female; Growth; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, | 1980 |
Treatment of drug-induced hypoglycemia.
Topics: Chlorpropamide; Diazoxide; Humans; Hypoglycemia | 1980 |
Neonatal hypoglycemia.
Topics: Diazoxide; England; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn | 1994 |
Paraneoplastic endocrine syndromes.
Topics: Acromegaly; Adrenocorticotropic Hormone; Aminoglutethimide; Bromocriptine; Calcitonin; Cushing Syndr | 1994 |
Familial nesidioblastosis in two sisters.
Topics: Adenoma, Islet Cell; Diazoxide; Fatal Outcome; Female; Humans; Hypoglycemia; Infant, Newborn; Pancre | 1995 |
Pancreatic glucagon levels in infants and children with hyperinsulinemia.
Topics: Adolescent; Adult; Child; Child, Preschool; Diazoxide; Female; Glucagon; Humans; Hyperinsulinism; Hy | 1995 |
Pre- and post-synaptic modulators of excitatory neurotransmission: comparative effects on hypoxia/hypoglycemia in cortical cultures.
Topics: Animals; Aspartic Acid; Benzopyrans; Calcium Channel Blockers; Cell Hypoxia; Cells, Cultured; Cerebr | 1994 |
Relapse of medically treated insulinoma following the development of thyrotoxicosis: an assessment of potential mechanisms.
Topics: Aged; C-Peptide; Diazoxide; Female; Humans; Hypoglycemia; Insulin; Insulin Resistance; Insulinoma; P | 1994 |
K+ channel activators, acute glucose tolerance and glibenclamide-induced hypoglycaemia in the hypertensive rat.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; | 1994 |
[Hyperinsulinemic hypoglycemia: a study of four cases].
Topics: Algorithms; Diazoxide; Female; Glucagon; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Insulin; Li | 1993 |
Prenatal diagnosis of familial neonatal hyperinsulinemia.
Topics: Administration, Oral; Amniotic Fluid; Blood Glucose; Diazoxide; Female; Fetal Blood; Glucose; Humans | 1993 |
The enigma of persistent hyperinsulinemic hypoglycemia of infancy.
Topics: Diazoxide; Glucagon; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, Newborn; Octreo | 1993 |
Short- and long-term use of octreotide in the treatment of congenital hyperinsulinism.
Topics: Diazoxide; Female; Follow-Up Studies; Glucagon; Glucose; Growth Disorders; Humans; Hyperinsulinism; | 1993 |
Persistent hyperinsulinemic hypoglycemia of infancy: long-term octreotide treatment without pancreatectomy.
Topics: Diazoxide; Female; Follow-Up Studies; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Male; | 1993 |
Octreotide reverses hyperinsulinemia and prevents hypoglycemia induced by sulfonylurea overdoses.
Topics: Adult; Blood Glucose; Diazoxide; Drug Overdose; Female; Glucose; Humans; Hyperinsulinism; Hypoglycem | 1993 |
Adenosine diphosphate as an intracellular regulator of insulin secretion.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Tr | 1996 |
Reversal of hypoglycaemia in murine malaria by drugs that inhibit insulin secretion.
Topics: Animals; Antimalarials; Blood Glucose; Diazoxide; Epinephrine; Hyperinsulinism; Hypoglycemia; Insuli | 1996 |
Role of nitric oxide in the effects of hypoglycemia on the cerebral circulation in awake goats.
Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Cerebrovascular Circulation; Diazoxide; Drug Inter | 1997 |
Therapy for persistent hyperinsulinemic hypoglycemia of infancy. Understanding the responsiveness of beta cells to diazoxide and somatostatin.
Topics: Blood Glucose; Cell Membrane; Diazoxide; Disease Management; Electrophysiology; Glycosyltransferases | 1997 |
Preoperative use of octreotide in a newborn with persistent hyperinsulinemic hypoglycemia of infancy.
Topics: Diazoxide; Female; Glucose; Hormones; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Octreo | 1998 |
Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alleles; Animals; ATP-Binding Cassette Transporters; | 1998 |
Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: a retrospective review of 77 cases and analysis of efficacy-predicting criteria.
Topics: Diazoxide; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hyperinsu | 1998 |
Histochemical, clinical, and in vitro beta cell responses in a neonate with persistent hyperinsulinaemic hypoglycaemia of infancy.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Diazoxide; Diuretics; Glucose; Humans; Hyperinsulinism | 1998 |
Loss of imprinted genes and paternal SUR1 mutations lead to hyperinsulinism in focal adenomatous hyperplasia.
Topics: Adenoma, Islet Cell; ATP-Binding Cassette Transporters; Chromosomes, Human, Pair 11; Diazoxide; Drug | 1998 |
Long-term follow up of persistent hyperinsulinaemic hypoglycaemia of infancy.
Topics: Diazoxide; Electroencephalography; Female; Follow-Up Studies; Head; Humans; Hyperinsulinism; Hypogly | 1998 |
Management of sulfonylurea ingestions.
Topics: Antidotes; Child; Diabetes Mellitus, Type 2; Diazoxide; Gastrointestinal Agents; Glucose; Humans; Hy | 1999 |
Involvement of adenosine triphosphate-sensitive K+ channels in glucose-sensing in the rat solitary tract nucleus.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diazoxide; Glyburide; Homeostasis; Hypoglycemia; Hyp | 2000 |
Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells.
Topics: Animals; Antihypertensive Agents; Dentate Gyrus; Diazoxide; Glyburide; Hypoglycemia; Hypoglycemic Ag | 2000 |
Insulin autoimmune syndrome: the second Dutch case.
Topics: Aged; Aged, 80 and over; Autoimmune Diseases; Blood Glucose; Diazoxide; Follow-Up Studies; Humans; H | 2001 |
Neurologic outcomes of 90 neonates and infants with persistent hyperinsulinemic hypoglycemia.
Topics: Age of Onset; Child; Child, Preschool; Developmental Disabilities; Diazoxide; Epilepsy; Humans; Hype | 2001 |
Transient hyperinsulinism in an asphyxiated newborn infant with hypoglycemia.
Topics: Asphyxia Neonatorum; Blood Glucose; Diazoxide; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Infan | 2001 |
Management of hyperinsulinemia with diazoxide in an elderly hemodialysis patient.
Topics: Aged; Aged, 80 and over; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Insulinoma; Nutrition Dis | 2001 |
Ten years' experience of persistent hyperinsulinaemic hypoglycaemia of infancy.
Topics: Adolescent; Blood Glucose; Chi-Square Distribution; Child; Child Development; Child, Preschool; Diaz | 2001 |
Diazoxide, glipizide, and hypoglycaemia.
Topics: Blood Glucose; Diabetes Mellitus; Diazoxide; Drug Antagonism; Glipizide; Humans; Hypoglycemia; Insul | 1977 |
[Hypoglycaemia (author's transl)].
Topics: Alcoholism; Diazoxide; Endocrine System Diseases; Enzymes; Glucose; Humans; Hydrocortisone; Hypoglyc | 1976 |
Hypoglycemia: a perspective.
Topics: Adenoma, Islet Cell; Citric Acid Cycle; Diabetes Complications; Diazoxide; Female; Glucose; Glucose | 1975 |
Von Gierke's disease: a review.
Topics: Allopurinol; Bicarbonates; Blood Glucose; Diazoxide; Gluconeogenesis; Glucose-6-Phosphatase; Glycoge | 1976 |
Neonatal hypoglycemia resulting from islet cell adenomatosis. Successful treatment with total pancreatectomy.
Topics: Adenoma, Islet Cell; Cortisone; Diazoxide; Female; Glucose; Humans; Hypoglycemia; Infant, Newborn; I | 1977 |
Insulinoma in the dog.
Topics: Adenoma, Islet Cell; Animals; Diazoxide; Dog Diseases; Dogs; Glucagon; Hypoglycemia; Insulin; Pancre | 1977 |
[The disease pattern of the diffuse, nesidioblastic hyperplasia of the pancreatic islets in newborn and infants (author's transl)].
Topics: Adenoma, Islet Cell; Diazoxide; Fatty Acids, Nonesterified; Humans; Hydroxybutyrates; Hypoglycemia; | 1978 |
Pancreatic adenomas in infants and children: current surgical management.
Topics: Adenoma, Islet Cell; Child; Child, Preschool; Diazoxide; Follow-Up Studies; Humans; Hyperinsulinism; | 1978 |
[Medical treatment of spontaneous hypoglycemic syndromes].
Topics: Adenoma, Islet Cell; Chlorpromazine; Diazoxide; Fasting; Glucagon; Glucose; Humans; Hypoglycemia; Li | 1979 |
[Description of a case of type I glycogenosis treated with diazoxide].
Topics: Diazoxide; Glycogen Storage Disease Type I; Humans; Hypoglycemia; Infant; Liver; Male; Seizures | 1978 |
Paradoxical enhancement of tolbutamide-induced insulin release by diazoxide in a patient with islet cell hyperplasia.
Topics: Blood Glucose; Child; Diazoxide; Glucagon; Glucose Tolerance Test; Humans; Hyperplasia; Hypoglycemia | 1978 |
Gastric carcinoma associated with severe hypoglycemia sensitive to diazoxide.
Topics: Adenocarcinoma; Aged; Blood Glucose; Diazoxide; Glucose Tolerance Test; Humans; Hypoglycemia; Insuli | 1979 |
[Pathogenesis of ketotic hypoglycemia (author's transl)].
Topics: Acidosis; Alanine; Child; Child, Preschool; Deoxyglucose; Diazoxide; Epinephrine; Fasting; Female; H | 1979 |
Management of chlorpropamide-induced hypoglycemia with diazoxide.
Topics: Aged; Chlorpropamide; Diazoxide; Humans; Hypoglycemia; Male | 1978 |
[9 years of diazoxide therapy in a case of infantile idiopathic hypolglycemia].
Topics: Child; Diazoxide; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Male; Prediabetic State; Se | 1978 |
Intravenous infusion of diazoxide in the treatment of chlorpropamide-induced hypoglycemia.
Topics: Child; Chlorpropamide; Diazoxide; Humans; Hypoglycemia; Infusions, Parenteral; Male | 1978 |
Oral diazoxide for hypoglycemia.
Topics: Administration, Oral; Animals; Diazoxide; Female; Humans; Hypoglycemia; Infant; Pregnancy | 1978 |
Growth hormone secretion and diazoxide induced hyperglycaemia.
Topics: Adult; Blood Glucose; Diazoxide; Growth Hormone; Humans; Hyperglycemia; Hypoglycemia; Male | 1978 |
Neonatal pancreatic beta-cell hyperplasia: report of a case with failure of diazoxide and benefit of early subtotal pancreatectomy.
Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; Infant, Newborn; Infant, Newb | 1976 |
[A case of idiopathic ketotic hypoglycemia successfully treated with diazoxid. (author's transl)].
Topics: Acidosis; Child, Preschool; Diazoxide; Female; Humans; Hypoglycemia; Ketosis | 1977 |
The management of severe preeclampsia and eclampsia with intravenous diazoxide.
Topics: Adolescent; Adult; Cesarean Section; Diazoxide; Eclampsia; Female; Humans; Hypertension; Hypoglycemi | 1977 |
Management of prolonged hypoglycaemia in Beckwith's syndrome.
Topics: Abnormalities, Multiple; Adrenal Cortex Hormones; Diazoxide; Hernia, Umbilical; Humans; Hypoglycemia | 1977 |
Hyperosmolar non-ketotic hyperglycaemia during oral diazoxide therapy of prolonged hyperglycaemia in infancy.
Topics: Age Factors; Diabetic Coma; Diazoxide; Humans; Hyperglycemic Hyperosmolar Nonketotic Coma; Hyperinsu | 1977 |
Chlorpropamide-induced hypoglycemia: successful treatment with diazoxide.
Topics: Adolescent; Chlorpropamide; Diazoxide; Glucagon; Glucose; Humans; Hypoglycemia; Insulin; Male | 1977 |
Letter: Diazoxide-diphenylhydantoin interaction.
Topics: Child, Preschool; Diazoxide; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Hypogly | 1976 |
[Leucine-sensitive hypoglycaemia and its treatment with diazoxide (author's transl)].
Topics: Amino Acid Metabolism, Inborn Errors; Blood Glucose; Diazoxide; Dietary Proteins; Female; Humans; Hy | 1976 |
Persistent neonatal hypoglycaemia. A clinical and histopathological study of three cases treated with diazoxide and subtotal pancreatectomy.
Topics: Biopsy; Birth Weight; Blood Glucose; Diazoxide; Female; Follow-Up Studies; Glucose Tolerance Test; H | 1975 |
[Diagnosis of organic hyperinsulinism].
Topics: Diagnosis, Differential; Diazoxide; Fasting; Glucagon; Glucose Tolerance Test; Humans; Hyperinsulini | 1975 |
Drug interaction: diazoxide and diphenylhydantoin.
Topics: Administration, Oral; Adolescent; Child, Preschool; Chromatography, Gas; Diazoxide; Drug Therapy, Co | 1975 |
[Therapeutic use of diazoxide in a probable case of idiopathic hypoglycemia in an infant].
Topics: Age Factors; Child, Preschool; Diazoxide; Female; Humans; Hypoglycemia | 1975 |
Hypertrichosis due to diazoxide.
Topics: Aged; Child; Diazoxide; Humans; Hypertension; Hypertrichosis; Hypoglycemia; Male | 1975 |
[Leucine sensitive hypoglycemia. Follow-up studies under treatment with diazoxide (author's transl)].
Topics: Blood Glucose; Diazoxide; Dietary Proteins; Drug Hypersensitivity; Epilepsy; Female; Humans; Hypertr | 1976 |
Mechanical and ionic response of rat aorta to diazoxide.
Topics: Animals; Aorta; Calcium; Calcium Radioisotopes; Diazoxide; Endothelium, Vascular; Hypoglycemia; Musc | 1992 |
Diazoxide--an orphan drug?
Topics: Child, Preschool; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant; Orphan Drug Production | 1992 |
Reactive hypoglycaemia in association with disordered islet function and abnormal hepatic glucose-6-phosphatase activity: response to diazoxide.
Topics: Adult; Blood Glucose; Diazoxide; Glucagon; Glucose Tolerance Test; Glucose-6-Phosphatase; Growth Hor | 1991 |
Reversal of microcephaly and developmental delay after cure of hyperinsulinemic hypoglycemia.
Topics: Blood Glucose; Child, Preschool; Developmental Disabilities; Diazoxide; Female; Humans; Hypoglycemia | 1990 |
A case of insulin-secreting tumor successfully treated with diazoxide.
Topics: Aged; Blood Glucose; Diazoxide; Humans; Hypoglycemia; Insulin; Insulinoma; Liver; Male; Pancreatic N | 1991 |
Diazoxide treatment of reactive hypoglycaemia.
Topics: Diazoxide; Gastrectomy; Humans; Hypoglycemia | 1991 |
Clinical spectrum of sulfonylurea overdose and experience with diazoxide therapy.
Topics: Diazoxide; Drug Overdose; Female; Glucose Solution, Hypertonic; Humans; Hypoglycemia; Male; Manitoba | 1991 |
Hypertrophic cardiomyopathy after prolonged diazoxide therapy for hyperinsulinemic hypoglycemia.
Topics: Adolescent; Cardiomyopathy, Hypertrophic; Diazoxide; Echocardiography; Humans; Hyperinsulinism; Hypo | 1991 |
Surgical management of islet cell dysmaturation syndrome in young children.
Topics: Adenoma; Combined Modality Therapy; Diazoxide; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; I | 1990 |
Hypertrichosis induced by diazoxide in idiopathic hypoglycemia of infancy.
Topics: Diazoxide; Female; Humans; Hypertrichosis; Hypoglycemia; Infant, Newborn | 1989 |
Complications of diazoxide treatment in persistent neonatal hyperinsulinism.
Topics: Blood Glucose; Diazoxide; Female; Heart Failure; Humans; Hyperinsulinism; Hypoglycemia; Infant; Insu | 1989 |
Hyperinsulinism in infancy.
Topics: Diazoxide; Diuretics; Female; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Male; Pancreas | 1989 |
[Hyperglycemic agents].
Topics: Blood Glucose; Chemical Phenomena; Chemistry; Diazoxide; Glucagon; Humans; Hyperglycemia; Hypoglycem | 1986 |
The hyperinsulinaemic hypoglycaemias in infancy: a study of six cases.
Topics: Biopsy; Blood Glucose; Diagnosis, Differential; Diazoxide; Female; Glucose Tolerance Test; Humans; H | 1988 |
[Hypoglycemic insular tumor or insulinoma].
Topics: Adenoma, Islet Cell; Diazoxide; Humans; Hypoglycemia; Insulinoma; Nervous System Diseases; Pancreate | 1986 |
Diazoxide in the management of patients with insulinoma.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Child, Preschool; Diazoxide; Edema; Female; Hir | 1986 |
Effect of diazoxide or glucagon on hepatic glucose production rate during extreme neonatal hypoglycaemia.
Topics: Blood Glucose; Diazoxide; Female; Glucagon; Humans; Hypoglycemia; Infant, Newborn; Insulin; Liver; M | 1987 |
[Acquired diffuse hypertrichosis during treatment with diazoxide in a newborn infant].
Topics: Diazoxide; Humans; Hypertrichosis; Hypoglycemia; Infant, Newborn; Male | 1988 |
Long-term treatment with diazoxide in childhood hyperinsulinism.
Topics: Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, Newborn; Intellectual Disability; | 1986 |
The diagnosis of hyperinsulinism in a child in the absence of hyperinsulinemia.
Topics: Adolescent; Diazoxide; Fatty Acids, Nonesterified; Female; Humans; Hyperinsulinism; Hypoglycemia; In | 1986 |
Persistent neonatal hyperinsulinemic hypoglycemia in two siblings successfully treated with diazoxide.
Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Male | 1986 |
Hypoglycemia due to organic hyperinsulinism in infancy.
Topics: Adenoma, Islet Cell; Adrenal Cortex Hormones; Diazoxide; Female; Humans; Hyperinsulinism; Hyperplasi | 1970 |
Editorial: Streptozotocin for islet-cell carcinoma.
Topics: Acute Kidney Injury; Adenoma, Islet Cell; Diabetes Insipidus; Diazoxide; Drug Evaluation; Humans; Hy | 1973 |
[Associated pancreatic insular infiltrations. Insulinoma, gastrinoma, glucagonoma. Clinical, biological, and anatomo-pathological data].
Topics: Adenoma; Adult; Aged; Blood Glucose; Diazoxide; Duodenal Ulcer; Female; Gastrectomy; Gastrins; Gluca | 1973 |
[Pancreatic adenoma and polyendocrine pathology].
Topics: Adenoma; Adrenal Gland Neoplasms; Autopsy; Blood Glucose; Cholecystokinin; Diazoxide; Glucagon; Gluc | 1973 |
Adult hypoglycaemia associated with neoplasia. A report of three cases with a note on the use of diazoxide.
Topics: Adenoma, Islet Cell; Adult; Antihypertensive Agents; Diazoxide; Female; Fibrosarcoma; Humans; Hypogl | 1966 |
Experimental diabetes due to insulin inhibition.
Topics: Animals; Chlorothiazide; Diabetes Mellitus; Diazoxide; Haplorhini; Hyperglycemia; Hypoglycemia; Insu | 1968 |
[A morphological study on the mechanism of insulin-release, using sulfonylurea, l-leucine, and alpha-ketocarboxylic acids].
Topics: Animals; Blood Glucose; Butyrates; Chlorpropamide; Diabetes Mellitus; Diazoxide; Ferredoxins; Histoc | 1968 |
Treatment of insulinoma with streptozotocin.
Topics: Adenoma, Islet Cell; Antibiotics, Antineoplastic; Chlorothiazide; Diazoxide; Humans; Hypoglycemia; M | 1969 |
Effects of diazoxide administration on plasma glucose, insulin, and lipids in Von Gierke's disease.
Topics: Antihypertensive Agents; Child; Diazoxide; Drug Eruptions; Drug Hypersensitivity; Glucose Tolerance | 1966 |
[Organic hypoglycemia due to Langerhans carcinoma. Treatment by diazoxide followed by streptozotocin].
Topics: Aged; Carcinoma; Diazoxide; Drug Therapy, Combination; Humans; Hypoglycemia; Islets of Langerhans; L | 1974 |
Clinical use of diazoxide and mechanism for its hyperglycemic effects.
Topics: Adenoma, Islet Cell; Adult; Benzothiadiazines; Blood Glucose; Diabetes Mellitus; Diazoxide; Epinephr | 1966 |
Subtotal pancreatectomy in the management of severe persistant idiopathic hypoglycemia in children.
Topics: Adolescent; Adrenocorticotropic Hormone; Child; Child, Preschool; Diazoxide; Diet; Ephedrine; Female | 1967 |
Blind pancreatic resection for suspected insulinoma: a review of the problem.
Topics: Adenoma; Adenoma, Islet Cell; Adult; Aged; Diabetes Mellitus; Diazoxide; Female; Humans; Hypoglycemi | 1967 |
Functioning islet cell adenoma in the newborn. Report of a case with failure of diazoxide.
Topics: Adenoma, Islet Cell; Adrenocorticotropic Hormone; Blood Glucose; Catecholamines; Corticosterone; Dia | 1968 |
Insulin-secreting bronchial carcinoid tumor with widespread metastases.
Topics: Adult; Blood Glucose; Bronchi; Bronchial Neoplasms; Carcinoma, Adenoid Cystic; Diazoxide; Female; Gl | 1968 |
Islet cell tumor in the neonate. Studies in carbohydrate metabolism and therapeutic response.
Topics: Adenoma; Adenoma, Islet Cell; Blood Glucose; Carbohydrate Metabolism; Diazoxide; Diet Therapy; Growt | 1968 |
Further studies on diazoxide suppression of insulin release from abnormal and normal islet tissue in man.
Topics: Adenoma, Islet Cell; Arginine; Blood Glucose; Catecholamines; Depression, Chemical; Diazoxide; Femal | 1968 |
The therapeutic application of diazoxide in pediatric hypoglycemic states.
Topics: Adenoma, Islet Cell; Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Glucose Tolerance Te | 1968 |
Metabolic effects of diazoxide in normal subjects, patients with diabetes mellitus, and patients with organic hypoglycemia.
Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; Diabetes Mellitus; Diazoxide; Fatty Acids, Nonester | 1968 |
Control of hypoglycemia with diazoxide and hormones.
Topics: Adenoma, Islet Cell; Adrenocorticotropic Hormone; Aged; Benzothiadiazines; Blood Glucose; Diazoxide; | 1968 |
Clinical and physiologic studies using diazoxide in the treatment of hypoglycemia.
Topics: Abdominal Neoplasms; Adenoma, Islet Cell; Adult; Animals; Blood Glucose; Diazoxide; Dogs; Female; Gl | 1968 |
Clinical experience with diazoxide.
Topics: Adenoma, Islet Cell; Adrenal Glands; Adult; Aged; Benzothiadiazines; Blood Glucose; Diabetes Mellitu | 1968 |
[Current drug therapy of organic hypoglycemia].
Topics: Adenoma, Islet Cell; Carcinoma, Hepatocellular; Diazoxide; Female; Glucagon; Humans; Hypoglycemia; L | 1968 |
[Apropos of a case of severe hypoglycemia. Present possibilities of diagnosis and treatment].
Topics: Adenoma, Islet Cell; Blood Glucose; Diagnosis, Differential; Diazoxide; Glucocorticoids; Glucose; Gl | 1968 |
[A case of hypoglycemic beta-langerhansian adenoma and secreting parathyroidian adenoma: polyadenomatosis].
Topics: Adenoma; Adenoma, Islet Cell; Arginine; Diazoxide; Female; Glucagon; Growth Hormone; Humans; Hydrone | 1968 |
[Insulin-secreting langerhansian beta-cell tumor in a woman with diabetes mellitus. Case report and literature review].
Topics: Adenoma, Islet Cell; Diabetes Complications; Diabetic Angiopathies; Diazoxide; Humans; Hyperinsulini | 1969 |
[Organic hypoglycemia in association with a malignant tumor and an islet cell adenoma. Determining role of blood insulin determination for the etiologic diagnosis and surgical procedure].
Topics: Adenoma; Adenoma, Islet Cell; Aged; Arginine; Carcinoma; Diazoxide; Female; Glucagon; Glucose Tolera | 1969 |
Pancreatic islet cell carcinoma with hyperinsulinism and probable, ectopic ACTH-MSH secretion.
Topics: Adenoma, Islet Cell; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Blood Glucose; Diazoxide; Gl | 1969 |
[Hypoglycemia and primary liver cancer. Hormone levels. Action of diazoxide].
Topics: Adult; Carcinoma, Hepatocellular; Diazoxide; Glucagon; Growth Hormone; Humans; Hypoglycemia; Insulin | 1967 |
[Continuous treatment with diazoxide of hypoglycemia due to hyperinsulinism].
Topics: Aged; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Mental Disorders; Obesity | 1970 |
Islet cell adenomatosis and adenoma in an infant.
Topics: Adenoma, Islet Cell; Adrenocorticotropic Hormone; Diazoxide; Glucose; Humans; Hypoglycemia; Infant, | 1971 |
[Islet cell adenoma].
Topics: Adenoma, Islet Cell; Adult; Aged; Angiography; Blood Glucose; Diazoxide; Female; Humans; Hyperinsuli | 1971 |
Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors.
Topics: Acromegaly; Adenoma, Islet Cell; Adolescent; Adult; Animals; Child; Chromatography, Gel; Cricetinae; | 1971 |
Surgical grand rounds from the University of Mississippi Medical Center. Management of hyperinsulinism.
Topics: Adenoma, Islet Cell; Diagnosis, Differential; Diazoxide; Dietary Carbohydrates; Female; Glucose Tole | 1971 |
Insulinomas: medical management as a successful alternative to surgical therapy.
Topics: Adenoma, Islet Cell; Child; Diazoxide; Humans; Hypoglycemia; Male; Pancreatic Neoplasms; Radiography | 1972 |
Beta cell adenoma in a child with hypoglycemia controlled with diazoxide.
Topics: Adenoma, Islet Cell; Blood Glucose; Child, Preschool; Diazoxide; Female; Glucose Tolerance Test; Hum | 1972 |
[Diazoxide treatment of infantile hypoglycaemia].
Topics: Adenoma, Islet Cell; Diagnosis, Differential; Diazoxide; Hirsutism; Humans; Hypoglycemia; Infant; Ma | 1972 |
Hypoglycemia due to hyperinsulinism treated by streptozotocin and diazoxide.
Topics: Adenoma, Islet Cell; Adult; Anti-Bacterial Agents; Diazoxide; Drug Synergism; Female; Humans; Hyperi | 1972 |
Pancreatic islet beta cell tumors and hyperplasia: experience in 14 Seattle hospitals.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Diazoxide; Female; Humans; Hyperinsulinism; Hyp | 1972 |
Diazoxide.
Topics: Adenoma, Islet Cell; Adult; Catecholamines; Cyclic AMP; Diazoxide; Glucose; Glycogen Storage Disease | 1972 |
Effect of diazoxide on golden hamsters with chronic hypoglycemia due to a transplantable islet-cell tumor.
Topics: Adenoma, Islet Cell; Administration, Oral; Adrenal Glands; Animals; Blood Glucose; Cricetinae; Diazo | 1972 |
[Indications and medical therapy of hypoglycemic beta-insular].
Topics: Adenoma, Islet Cell; Adrenal Cortex Hormones; Antineoplastic Agents; Carcinoma; Diazoxide; Diuretics | 1973 |
The insulin-glucose ration in children with islet cell tumors of the pancreas.
Topics: Adenoma, Islet Cell; Blood Glucose; Child; Diazoxide; Fasting; Glucose Tolerance Test; Humans; Hypog | 1974 |
[Exploration of hypoglycemia].
Topics: Adenoma, Islet Cell; Arginine; Blood Glucose; Diazoxide; Diet; Fasting; Glucagon; Hormones, Ectopic; | 1974 |
Beta-islet cell tumors of the pancreas: results of a study on 1,067 cases.
Topics: Adenoma, Islet Cell; Adult; Age Factors; Angiography; Child, Preschool; Diazoxide; Female; Glucose T | 1974 |
Hypoglycemia in infancy caused by beta cell nesidioblastosis.
Topics: Adenoma, Islet Cell; Cell Division; Diazoxide; Humans; Hypoglycemia; Infant; Male; Microscopy, Elect | 1974 |
[Prolonged treatment of severe hypoglycemia with diazoxide].
Topics: Adenoma, Islet Cell; Aged; Diazoxide; Drug Eruptions; Edema; Female; Gastrointestinal Diseases; Gout | 1974 |
Diazoxide, encorton and streptozotocin in the treatment of malignant betacytoma.
Topics: Adenoma, Islet Cell; Adult; Autopsy; Diazoxide; Female; Glucose; Humans; Hypoglycemia; Liver Neoplas | 1974 |
Fasting hypoglycemia. Diazoxide as a test for endogenous insulin release.
Topics: Adenoma, Islet Cell; Diazoxide; Fasting; Female; Humans; Hypoglycemia; Insulin; Middle Aged | 1974 |
Pluriglandular syndrome with hyperinsulinism. Cardiomegaly as a possible complication of diazoxide therapy.
Topics: Blood Glucose; Blood Pressure; Cardiomegaly; Child; Diazoxide; Female; Hirsutism; Humans; Hypercalce | 1968 |
[Hypoglycemic islet cell adenomas, apropos of their arteriographic diagnosis and surgical treatment].
Topics: Adenoma, Islet Cell; Angiography; Celiac Artery; Diazoxide; Duodenum; Humans; Hypoglycemia; Liver Ne | 1969 |
[Endocrine polyadenomatosis. General review and case report].
Topics: Adenoma; Adenoma, Islet Cell; Diazoxide; Female; Humans; Hydronephrosis; Hyperinsulinism; Hypoglycem | 1969 |
[Treatment of idiopathic hypoglycemia with diazoxide].
Topics: Child; Diazoxide; Hirsutism; Humans; Hypoglycemia; Male; Thrombocytopenia | 1974 |
Oral diazoxide in uncontrolled malignant hypertension.
Topics: Administration, Oral; Creatinine; Diazoxide; Edema; Furosemide; Humans; Hypertension, Malignant; Hyp | 1974 |
Effect of drugs on carbohydrate metabolism.
Topics: Adult; Blood Glucose; Caffeine; Carbohydrate Metabolism; Carbohydrate Metabolism, Inborn Errors; Chi | 1974 |
[Proceedings: Cellular calcium and insulin secretion. Morphologic studies of B-cells in the mouse following tolbutamide and diazoxide administration].
Topics: Animals; Calcium; Depression, Chemical; Diazoxide; Hypoglycemia; Insulin; Insulin Secretion; Islets | 1974 |
Metabolic aspects of the Beckwith-Wiedemann syndrome.
Topics: Abnormalities, Multiple; Adrenal Gland Diseases; Blood Glucose; Child, Preschool; Diazoxide; Epineph | 1973 |
Idiopathic hypoglycaemia.
Topics: Blood Glucose; Child, Preschool; Diazoxide; Electroencephalography; Female; Glucagon; Glucose; Growt | 1973 |
Diazoxide therapy in the syndrome of Beckwith-Weidemann-Coombs.
Topics: Abnormalities, Multiple; Adrenal Gland Diseases; Blood Glucose; Child, Preschool; Diazoxide; Epineph | 1973 |
[Current possibilities for therapy of usually untreatable hypertonic crises and hypoglycemias].
Topics: Adult; Child; Diazoxide; Female; Humans; Hypertension; Hypoglycemia; Pregnancy | 1973 |
Evaluation of diazoxide. (Hyperstat I.V.).
Topics: Administration, Oral; Age Factors; Blood Pressure; Cardiac Output; Child; Diazoxide; Emergencies; Ev | 1973 |
[Extragonadal endocrine manifestations of Klinefelter's disease].
Topics: Adrenal Gland Diseases; Adult; Antibodies; Autoantibodies; Blood Glucose; Diabetes Mellitus; Diazoxi | 1973 |
[Diazoxide as therapy for idiopathic hypoglycemia in children (author's transl)].
Topics: Catecholamines; Child; Child, Preschool; Cyanosis; Diazoxide; Diet Therapy; Fasting; Female; Fever; | 1974 |
Plasma insulin and blood glucose during long-term treatment with diazoxide for infant hypoglycemia.
Topics: Acidosis; Blood Glucose; Child, Preschool; Diazoxide; Follow-Up Studies; Glucose; Glucose Tolerance | 1974 |
[Wiedemann-Beckwith syndrome. Clinical and metabolic study of 4 cases].
Topics: Abnormalities, Multiple; Child, Preschool; Diazoxide; Hernia, Umbilical; Humans; Hypoglycemia; Male; | 1974 |
Chlorpromazine in the treatment of endogenous organic hyperinsulinism.
Topics: Adult; Bendroflumethiazide; Blood Glucose; Chlorpromazine; Diazoxide; Female; Glucose Tolerance Test | 1974 |
A-cell deficiency and B-cell hyperplasia of Langerhans' islet as a cause of leucine sensitive hypoglycemia.
Topics: Blood Glucose; Diazoxide; Epinephrine; Glucose Tolerance Test; Humans; Hyperplasia; Hypoglycemia; In | 1968 |
Adenosine triphosphate levels of mammalian pancreatic B cells after stimulation with glucose and hypoglycemic sulfonylureas.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Female; Fluorometry; Glucose; Glycogen; Hyperglycemia; H | 1969 |
Complementary arguments in favor of the betacytotrophic action of the hypglycemic sulfonamides.
Topics: Animals; Diabetes Mellitus; Diazoxide; Dogs; Glucose; Hyperplasia; Hypoglycemia; Hypoglycemic Agents | 1970 |
[Hyperglycemic and insulin-depressing effect of diazoxide in a case of hyperinsulinism caused by beta-insular hyperplasia].
Topics: Aged; Blood Glucose; Diazoxide; Female; Humans; Hyperplasia; Hypoglycemia; Insulin; Insulin Secretio | 1971 |
Leucine-sensitive hypoglycaemia treated with diazoxide.
Topics: Blood Glucose; Diazoxide; Female; Humans; Hypoglycemia; Infant; Infant, Newborn; Leucine; Male | 1967 |
Leucine-sensitive hypoglycaemia.
Topics: Adolescent; Diazoxide; Diet Therapy; Epilepsy, Tonic-Clonic; Female; Humans; Hypoglycemia; Leucine | 1970 |
Clinical value and mode of action of chlorpropamide in diabetes insipidus.
Topics: Adolescent; Adult; Chlorpropamide; Diabetes Insipidus; Diazoxide; Drinking Behavior; Female; Humans; | 1970 |
Neonatal hypoglycemia: a discussion.
Topics: Anticonvulsants; Diazoxide; Diet Therapy; Epinephrine; Female; Glucagon; Glucose; Glucose Tolerance | 1971 |
Ketotic (idiopathic glucagon unresponsive) hypoglycaemia: diazoxide effects.
Topics: Acidosis; Birth Weight; Blood Glucose; Child; Child, Preschool; Diazoxide; Fasting; Female; Glucagon | 1972 |
[Value of diazoxide in the treatment of neonatal hypoglycemia].
Topics: Blood Glucose; Diazoxide; Female; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; | 1972 |
[Effects of prolonged treatment with Diazoxide in 2 cases of spontaneous hypoglycemia in adults].
Topics: Adult; Bendroflumethiazide; Diazoxide; Humans; Hypoglycemia; Insulin; Male; Middle Aged; Water-Elect | 1971 |
[Diazoxide in the therapy of leucin sensitive hypoglycemia].
Topics: Carbohydrate Metabolism, Inborn Errors; Diazoxide; Humans; Hyperinsulinism; Hypertrichosis; Hypoglyc | 1971 |
The clinical use of diazoxide in leucine-sensitive hypoglycemia.
Topics: Amino Acid Metabolism, Inborn Errors; Child, Preschool; Diazoxide; Female; Humans; Hyperglycemia; Hy | 1968 |
The use of diazoxide in hypoglycemia in childhood.
Topics: Amino Acid Metabolism, Inborn Errors; Blood Glucose; Child; Child, Preschool; Diazoxide; Glucocortic | 1968 |
Hypertrichosis lanuginosa associated with diazoxide therapy in prepubertal children: a clinicopathologic study.
Topics: Androgens; Child, Preschool; Diazoxide; Female; Hair; Humans; Hypertrichosis; Hypoglycemia; Infant; | 1968 |
Studies in a patient with retroperitoneal sarcoma associated with severe hypoglycemia.
Topics: Aged; Blood Glucose; Diazoxide; Female; Glucagon; Glucose Tolerance Test; Humans; Hypoglycemia; Infu | 1968 |
Diazoxide therapy of intractable hypoglycemia.
Topics: Adrenal Medulla; Adult; Benzothiadiazines; Blood Glucose; Child, Preschool; Diazoxide; Epinephrine; | 1968 |
Clinical studies in the use of oral diazoxide in postsurgical and functional hypoglycemia.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Blood Glucose; Catecholamines; Diazox | 1968 |
New approaches to medical management of organic hypoglycemias.
Topics: Child, Preschool; Diazoxide; Diuretics; Humans; Hypoglycemia; Sulfanilamides | 1966 |
Hepatic glycogen storage disease. Clinical and laboratory findings in 23 cases.
Topics: Child; Child, Preschool; Diazoxide; Diet Therapy; Female; Fructose; Galactose; Glucose Tolerance Tes | 1971 |
A possible role for the exocrine pancreas in the pathogenesis of neonatal leucine-sensitive hypoglycemia.
Topics: Diazoxide; Exocrine Glands; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Leucin | 1970 |
Diazoxide for hyperinsulinism.
Topics: Adult; Animals; Child; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia | 1970 |
[Treatment of hypoglycemia in children by diazoxide and immunoreactive insulin depressive action].
Topics: Blood Glucose; Child, Preschool; Diazoxide; Female; Humans; Hypoglycemia; Infant; Insulin; Insulin S | 1970 |
Contribution to the pathogenesis of tumour hypoglycaemia.
Topics: Blood Glucose; Diazoxide; Fatty Acids, Nonesterified; Fibrosarcoma; Gluconeogenesis; Glycolysis; Hum | 1970 |
[The use of Diazoxid in spontaneous hypoglycemia syndrome].
Topics: Adult; Aged; Diazoxide; Female; Humans; Hypoglycemia; Middle Aged | 1970 |
[Initial hypoglycemic manifestations in a familial form of isolated somatotropin deficiency].
Topics: Blood Glucose; Body Height; Carbohydrate Metabolism, Inborn Errors; Child, Preschool; Diazoxide; Dwa | 1970 |
The critically ill child: hypoglycemia.
Topics: Child; Diazoxide; Endocrine System Diseases; Fasting; Glucose; Humans; Hypoglycemia; Infant; Infant, | 1970 |
AO44: an improved hyperglycemic agent.
Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Diazoxide; Diuresis; Dogs; Epinephrine | 1971 |
Ketotic hypoglycemia. New observations.
Topics: Acidosis; Blood Glucose; Child; Diazoxide; Ephedrine; Glucagon; Glucose; Humans; Hypoglycemia; Keton | 1971 |
[Diazoxide therapy of spontaneous hypoglycemia].
Topics: Diazoxide; Humans; Hypoglycemia | 1967 |
[Clinical observations and experimental findings in the treatment of hyperinsulinism with diazoxide].
Topics: Animals; Diazoxide; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemia | 1967 |
[Hypoglycemia in the course of secondary liver neoplasm].
Topics: Diazoxide; Glucagon; Humans; Hypoglycemia; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis | 1968 |
[Can organic hypoglycemia in adults be medically treated?].
Topics: Adrenal Cortex Hormones; Adult; Age Factors; Diazoxide; Diet Therapy; Drug Synergism; Hormones; Huma | 1968 |
Idiopathic neonatal hypoglycaemia treated with diazoxide.
Topics: Diazoxide; Female; Glucagon; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Pancr | 1969 |
Diazoxide in the management of hypoglycemia in infancy and childhood.
Topics: Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Glucose; Glucose Tolerance Test; Growth H | 1969 |
Hypertichosis lanuginosa acquisita.
Topics: Diazoxide; Humans; Hypertrichosis; Hypoglycemia; Infant; Leucine; Male; Pancreatectomy; Seizures | 1969 |
A fatal reaction to diazoxide.
Topics: Anuria; Diazoxide; Female; Fibrosarcoma; Humans; Hypoglycemia; Middle Aged; Pleural Neoplasms; Radio | 1969 |
Importance of dissolution rates in producing effective diazoxide blood levels in man.
Topics: Aged; Blood; Blood Pressure; Diazoxide; Female; Glucose; Humans; Hypertension; Hypoglycemia; Injecti | 1965 |
The treatment of hypoglycaemia with diazoxide.
Topics: Blood Glucose; Child, Preschool; Diazoxide; Glucose Tolerance Test; Humans; Hypoglycemia; Infant; Ma | 1966 |
Leucine-sensitive hypoglycemia. Treatment with zinc glucagon and corticosteroids.
Topics: Diazoxide; Diet; Female; Glucagon; Humans; Hypoglycemia; Leucine; Middle Aged; Prednisone | 1966 |
Effect of treatment with diazoxide and chlorothiazide on a child with leucine-sensitive hypoglycaemia.
Topics: Child, Preschool; Chlorothiazide; Diazoxide; Female; Glucose Tolerance Test; Humans; Hypoglycemia; L | 1966 |
Diazoxide in the treatment of infantile hypoglycemia.
Topics: Autoanalysis; Diazoxide; Drug Hypersensitivity; Female; Glucose Tolerance Test; Hirsutism; Humans; H | 1966 |
[Treatment with diazoxide of a case of infantile hypoglycemia].
Topics: Blood Glucose; Diazoxide; Electroencephalography; Humans; Hypoglycemia; Infant; Male; Trichlormethia | 1966 |