diazoxide has been researched along with Experimental Spinal Cord Ischemia in 7 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "However, the effects of DZ in spinal cord ischemia-reperfusion injury have not been fully elucidated." | 5.51 | Pretreatment With Diazoxide Attenuates Spinal Cord Ischemia-Reperfusion Injury Through Signaling Transducer and Activator of Transcription 3 Pathway. ( Aftab, M; Cleveland, JC; Eldeiry, M; Fullerton, DA; Meng, X; Reece, TB; Roda, G; Ryan, TJ; Weyant, MJ; Yamanaka, K, 2019) |
| "However, the effects of DZ in spinal cord ischemia-reperfusion injury have not been fully elucidated." | 1.51 | Pretreatment With Diazoxide Attenuates Spinal Cord Ischemia-Reperfusion Injury Through Signaling Transducer and Activator of Transcription 3 Pathway. ( Aftab, M; Cleveland, JC; Eldeiry, M; Fullerton, DA; Meng, X; Reece, TB; Roda, G; Ryan, TJ; Weyant, MJ; Yamanaka, K, 2019) |
| "Spinal cord ischemia was induced by a 4-min thoracic aortic cross-clamp." | 1.51 | Synergetic Induction of NGF With Diazoxide and Erythropoietin Attenuates Spinal Cord Ischemic Injury. ( Aftab, M; Eldeiry, M; Fullerton, DA; Meng, X; Reece, TB; Ryan, TJ; Weyant, MJ; Yamanaka, K, 2019) |
| "Western blot analysis demonstrated that optimal βcR up-regulation occurred at 36 hours after DZ administration, and the optimal DZ dosage for βcR induction was 20 mg/kg." | 1.48 | Optimized induction of beta common receptor enhances the neuroprotective function of erythropoietin in spinal cord ischemic injury. ( Aftab, M; Cleveland, JC; Eldeiry, M; Fullerton, DA; Mares, J; Meng, X; Reece, TB; Ryan, TJ; Weyant, MJ; Yamanaka, K, 2018) |
| "Diazoxide (DZ) has been shown to induce ischemic tolerance." | 1.48 | Synergistic Reduction of Apoptosis With Diazoxide and Erythropoietin in Spinal Cord Ischemic Injury. ( Aftab, M; Cleveland, JC; Eldeiry, M; Fullerton, DA; Mares, J; Meng, X; Reece, TB; Ryan, TJ; Weyant, MJ; Yamanaka, K, 2018) |
| "Diazoxide (5 mg/kg) were given 48 h before 20 min ischemia in the 48-h DZ group, whereas 15-min DZ group received diazoxide (5 mg/kg) 15 min before 20-min ischemia." | 1.35 | Delayed pharmacological pre-conditioning effect of mitochondrial ATP-sensitive potassium channel opener on neurologic injury in a rabbit model of spinal cord ischemia. ( Choe, G; Chung, SH; Kim, CS; Kim, KO, 2008) |
| "Diazoxide-treated animals were dosed (5 mg/kg) 15 minutes before cross-clamp." | 1.31 | Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia. ( Baumgartner, WA; Bethea, BT; Blue, ME; Caparrelli, DJ; Cattaneo, SM; Eberhart, C; Gott, VL; Johnston, MV; Marbán, E; Shake, JG, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamanaka, K | 4 |
| Eldeiry, M | 4 |
| Aftab, M | 4 |
| Mares, J | 2 |
| Ryan, TJ | 4 |
| Meng, X | 4 |
| Weyant, MJ | 4 |
| Cleveland, JC | 3 |
| Fullerton, DA | 4 |
| Reece, TB | 4 |
| Roda, G | 1 |
| Caparrelli, DJ | 1 |
| Cattaneo, SM | 1 |
| Bethea, BT | 1 |
| Shake, JG | 1 |
| Eberhart, C | 1 |
| Blue, ME | 1 |
| Marbán, E | 1 |
| Johnston, MV | 1 |
| Baumgartner, WA | 1 |
| Gott, VL | 1 |
| Toumpoulis, IK | 1 |
| Anagnostopoulos, CE | 1 |
| Kim, KO | 1 |
| Choe, G | 1 |
| Chung, SH | 1 |
| Kim, CS | 1 |
7 other studies available for diazoxide and Experimental Spinal Cord Ischemia
| Article | Year |
|---|---|
Optimized induction of beta common receptor enhances the neuroprotective function of erythropoietin in spinal cord ischemic injury.
Topics: Animals; Diazoxide; Erythropoietin; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Receptor | 2018 |
Synergistic Reduction of Apoptosis With Diazoxide and Erythropoietin in Spinal Cord Ischemic Injury.
Topics: Animals; Apoptosis; Diazoxide; Erythropoietin; Mice; Receptors, Erythropoietin; Spinal Cord Ischemia | 2018 |
Pretreatment With Diazoxide Attenuates Spinal Cord Ischemia-Reperfusion Injury Through Signaling Transducer and Activator of Transcription 3 Pathway.
Topics: Administration, Oral; Animals; Blotting, Western; Diazoxide; Disease Models, Animal; Male; Mice; Mic | 2019 |
Synergetic Induction of NGF With Diazoxide and Erythropoietin Attenuates Spinal Cord Ischemic Injury.
Topics: Animals; Aortic Aneurysm, Thoracic; Diazoxide; Disease Models, Animal; Drug Synergism; Erythropoieti | 2019 |
Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia.
Topics: Animals; Diazoxide; Ischemic Preconditioning; Male; Membrane Proteins; Necrosis; Neurologic Examinat | 2002 |
Early ischemic preconditioning for spinal cord protection.
Topics: Animals; Diazoxide; Ischemic Preconditioning; Rabbits; Spinal Cord Ischemia; Swine; Vasodilator Agen | 2003 |
Delayed pharmacological pre-conditioning effect of mitochondrial ATP-sensitive potassium channel opener on neurologic injury in a rabbit model of spinal cord ischemia.
Topics: Analgesics; Animals; Blood Gas Analysis; Diazoxide; Disease Models, Animal; Ischemic Preconditioning | 2008 |