diazoxide has been researched along with Edema in 15 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether the common side effect of ankle oedema with arteriolar vasodilators such as the calcium entry blocker (CEB) nifedipine and the potassium channel opener (PCO) diazoxide is the direct result of peripheral vasodilation or merely a consequence of renal sodium retention." | 9.08 | Oedema formation with the vasodilators nifedipine and diazoxide: direct local effect or sodium retention? ( de Jong, DJ; Huysmans, FT; Kloke, HJ; Koene, RA; van Hamersvelt, HW, 1996) |
| " The relatively high prevalence of neutropenia, thrombocytopenia, and hyperuricemia suggests the value in proactively screening for these side effects in children treated with diazoxide." | 7.88 | Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide. ( Avitabile, CM; De León, DD; Givler, S; Herrera, A; Lord, K; Mitteer, L; Vajravelu, ME, 2018) |
| "Diazoxide is a non-diuretic benzothiadiazine derivative, one of a group of substances introduced into clinical practice in the 1950s for the treatment of hypertension." | 5.43 | Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( Inoue, Y; Komatsu, Y; Miyoshi, H; Nakamura, A; Tajima, K; Takano, T; Takihata, M; Terauchi, Y; Tsuchiya, H; Yahagi, S; Yamakawa, T; Yoshida, M, 2016) |
| "To determine whether the common side effect of ankle oedema with arteriolar vasodilators such as the calcium entry blocker (CEB) nifedipine and the potassium channel opener (PCO) diazoxide is the direct result of peripheral vasodilation or merely a consequence of renal sodium retention." | 5.08 | Oedema formation with the vasodilators nifedipine and diazoxide: direct local effect or sodium retention? ( de Jong, DJ; Huysmans, FT; Kloke, HJ; Koene, RA; van Hamersvelt, HW, 1996) |
| " The relatively high prevalence of neutropenia, thrombocytopenia, and hyperuricemia suggests the value in proactively screening for these side effects in children treated with diazoxide." | 3.88 | Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide. ( Avitabile, CM; De León, DD; Givler, S; Herrera, A; Lord, K; Mitteer, L; Vajravelu, ME, 2018) |
| "The protective effects of diazoxide were primarily manifest as a better preservation of diastolic function and a reduction of myocardial edema." | 3.70 | Opening of mitochondrial potassium channels: a new target for graft preservation strategies? ( Kevelaitis, E; Menasché, P; Mouas, C; Oubenaissa, A; Peynet, J, 2000) |
| "Diazoxide is a non-diuretic benzothiadiazine derivative, one of a group of substances introduced into clinical practice in the 1950s for the treatment of hypertension." | 1.43 | Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( Inoue, Y; Komatsu, Y; Miyoshi, H; Nakamura, A; Tajima, K; Takano, T; Takihata, M; Terauchi, Y; Tsuchiya, H; Yahagi, S; Yamakawa, T; Yoshida, M, 2016) |
| "Diazoxide treatment remains the mainstay of medical therapy." | 1.32 | A case of severe diazoxide toxicity. ( Camporesi, A; Mandelli, A; Salvo, I; Silvani, P; Wolfler, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herrera, A | 1 |
| Vajravelu, ME | 1 |
| Givler, S | 1 |
| Mitteer, L | 1 |
| Avitabile, CM | 1 |
| Lord, K | 1 |
| De León, DD | 1 |
| Martínez-Ortega, AJ | 1 |
| Mangas-Cruz, MA | 1 |
| Aliaga-Verdugo, A | 1 |
| Acosta-Delgado, D | 1 |
| Yoshida, K | 1 |
| Kawai, M | 1 |
| Marumo, C | 1 |
| Kanazawa, H | 1 |
| Matsukura, T | 1 |
| Kusuda, S | 1 |
| Yorifuji, T | 1 |
| Heike, T | 1 |
| Komatsu, Y | 1 |
| Nakamura, A | 1 |
| Takihata, M | 1 |
| Inoue, Y | 1 |
| Yahagi, S | 1 |
| Tajima, K | 1 |
| Tsuchiya, H | 1 |
| Takano, T | 1 |
| Yamakawa, T | 1 |
| Yoshida, M | 1 |
| Miyoshi, H | 1 |
| Terauchi, Y | 1 |
| Silvani, P | 1 |
| Camporesi, A | 1 |
| Mandelli, A | 1 |
| Wolfler, A | 1 |
| Salvo, I | 1 |
| Strahlendorf, JC | 1 |
| Acosta, S | 1 |
| Strahlendorf, HK | 1 |
| van Hamersvelt, HW | 1 |
| Kloke, HJ | 1 |
| de Jong, DJ | 1 |
| Koene, RA | 1 |
| Huysmans, FT | 1 |
| Kevelaitis, E | 1 |
| Oubenaissa, A | 1 |
| Mouas, C | 1 |
| Peynet, J | 1 |
| Menasché, P | 1 |
| Goode, PN | 1 |
| Farndon, JR | 1 |
| Anderson, J | 1 |
| Johnston, ID | 1 |
| Morte, JA | 1 |
| Saric, R | 1 |
| Moreau, F | 1 |
| Seguin, G | 1 |
| Cohen, E | 1 |
| Merlet, M | 1 |
| Lorin, JC | 1 |
| Martin, JD | 1 |
| Fang, P | 1 |
| MacDonald, I | 1 |
| Laver, M | 1 |
| Hua, A | 1 |
| Kincaid-Smith, P | 1 |
| Thurston, H | 1 |
| Pohl, JE | 1 |
| Swales, JD | 1 |
| Wolff, F | 1 |
| Hirsch, E | 1 |
| Wales, J | 1 |
| Viktora, J | 1 |
| Finnerty, FA | 1 |
1 trial available for diazoxide and Edema
| Article | Year |
|---|---|
Oedema formation with the vasodilators nifedipine and diazoxide: direct local effect or sodium retention?
Topics: Adult; Cross-Over Studies; Diazoxide; Edema; Female; Humans; Male; Nifedipine; Reproducibility of Re | 1996 |
14 other studies available for diazoxide and Edema
| Article | Year |
|---|---|
Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide.
Topics: Congenital Hyperinsulinism; Diazoxide; Dose-Response Relationship, Drug; Drug Administration Schedul | 2018 |
[Hirata's disease: report of a case].
Topics: Aged, 80 and over; Asian People; Autoimmune Diseases; Diazoxide; Drug Substitution; Edema; HLA-D Ant | 2014 |
High prevalence of severe circulatory complications with diazoxide in premature infants.
Topics: Birth Weight; Blood Circulation; Congenital Hyperinsulinism; Diazoxide; Ductus Arteriosus, Patent; E | 2014 |
Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Diazoxide; Drug Monitoring; Drug Resistance; Edema | 2016 |
A case of severe diazoxide toxicity.
Topics: Blood Glucose; Diazoxide; Edema; Heart Failure; Humans; Hyperinsulinism; Infant; Male; Pancreatectom | 2004 |
Diazoxide and cyclothiazide convert AMPA-induced dark cell degeneration of Purkinje cells to edematous damage in the cerebellar slice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Cerebellum; Di | 1996 |
Opening of mitochondrial potassium channels: a new target for graft preservation strategies?
Topics: Analysis of Variance; Animals; Diazoxide; Disaccharides; Edema; Electrolytes; Endothelium, Vascular; | 2000 |
Diazoxide in the management of patients with insulinoma.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Child, Preschool; Diazoxide; Edema; Female; Hir | 1986 |
[Prolonged treatment of severe hypoglycemia with diazoxide].
Topics: Adenoma, Islet Cell; Aged; Diazoxide; Drug Eruptions; Edema; Female; Gastrointestinal Diseases; Gout | 1974 |
The management of hypertensive disease of pregnancy.
Topics: Blood Pressure; Diazoxide; Eclampsia; Edema; Estrogens; Female; Guanethidine; Humans; Hypertension; | 1974 |
Oral diazoxide in uncontrolled malignant hypertension.
Topics: Administration, Oral; Creatinine; Diazoxide; Edema; Furosemide; Humans; Hypertension, Malignant; Hyp | 1974 |
The effect of oral diazoxide on hypertension and sodium excretion in chronic renal failure.
Topics: Blood Glucose; Carbohydrates; Creatinine; Diazoxide; Edema; Glomerulonephritis; Humans; Hypertension | 1973 |
Experimental and clinical studies with diazoxide.
Topics: Agammaglobulinemia; Animals; Blood Glucose; Diazoxide; Dogs; Edema; Epilepsy; Epinephrine; Female; H | 1968 |
Advantages and disadvantages of furosemide in the edematous states of pregnancy.
Topics: Diazoxide; Edema; Female; Furosemide; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Car | 1969 |