diazoxide has been researched along with Diabetes Mellitus in 52 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Right atrial sections from four patient groups-non-diabetic, insulin-dependent diabetes mellitus (IDDM), non-insulin-dependent diabetes mellitus (NIDDM) receiving glibenclamide, and NIDDM receiving metformin-were subjected to one of the following protocols: aerobic control, simulated ischemia/reoxygenation, ischemic preconditioning before ischemia, and pharmacological preconditioning with alpha 1 agonist phenylephrine, adenosine, the mito-K(ATP) channel opener diazoxide, the protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA), or the p38 mitogen-activated protein kinase (p38MAPK) activator anisomycin." | 3.73 | Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium. ( Fowler, A; Galiñanes, M; Hassouna, A; Loubani, M; Matata, BM; Standen, NB, 2006) |
| "Insulin binding to monocytes was assessed before and after plasma insulin suppression by diazoxide in 14 obesity-related diabetic subjects." | 3.66 | Role of insulin receptors in obesity-related diabetes. ( Blackard, WG; Taylon, A, 1982) |
| " Clearances were slightly improved by clonidine, claimed to be useful in hypertension associated with chronic renal failure." | 3.65 | Study of renal functions by repeated constant infusion of radiotracers before and after initiation of therapy in hypertension or in diabetes mellitus. ( Mirouze, J; Monnier, L; Olivier, C, 1975) |
| "Suppression of pancreatic glucagon secretion by hyperglycemia is a characteristic of normal alpha cell function." | 3.65 | The effect of experimental insulin deficiency on glucagon secretion. ( Faloona, GR; Müller, WA; Unger, RH, 1971) |
| "Diazoxide 5 mg/kg/day was administered to four normal subjects for five days and, together with insulin, to ten diabetic subjects for seven days." | 2.64 | Improvement in insulin secretion in diabetes after diazoxide. ( Greenwood, RH; Hales, CN; Mahler, RF, 1976) |
| "All four patients with mental retardation had a delay in the maintenance of euglycemia, and three of them also had seizure disorder." | 1.43 | Clinical characteristics and long-term outcome of Taiwanese children with congenital hyperinsulinism. ( Chiu, PC; Lee, CT; Liu, SY; Tsai, WY; Tung, YC; Wu, MZ, 2016) |
| "Treatment with diazoxide and chlorothiazide was effective." | 1.31 | The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy. ( Barbetti, F; Brusgaard, K; Buettger, C; Christesen, HB; Cuesta-Munoz, A; Hansen, T; Jacobsen, BB; Magnuson, MA; Massa, O; Matschinsky, FM; Odili, S; Shiota, C, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (73.08) | 18.7374 |
| 1990's | 5 (9.62) | 18.2507 |
| 2000's | 5 (9.62) | 29.6817 |
| 2010's | 4 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kandasamy, B | 1 |
| Shyng, SL | 1 |
| Lee, CT | 1 |
| Liu, SY | 1 |
| Tung, YC | 1 |
| Chiu, PC | 1 |
| Wu, MZ | 1 |
| Tsai, WY | 1 |
| Brauner, R | 1 |
| Serreau, R | 1 |
| Souberbielle, JC | 1 |
| Pouillot, M | 1 |
| Grouazel, S | 1 |
| Recasens, C | 1 |
| Zerah, M | 1 |
| Sainte-Rose, C | 1 |
| Treluyer, JM | 1 |
| Vieira, TC | 1 |
| Bergamin, CS | 1 |
| Gurgel, LC | 1 |
| Moisés, RS | 1 |
| Guldstrand, M | 1 |
| Grill, V | 1 |
| Björklund, A | 1 |
| Lins, PE | 1 |
| Adamson, U | 1 |
| Bingham, E | 1 |
| Hopkins, D | 1 |
| Pernet, A | 1 |
| Reid, H | 1 |
| Macdonald, IA | 1 |
| Amiel, SA | 1 |
| WOLFF, FW | 1 |
| LANGDON, RG | 1 |
| LUNDVALL, O | 1 |
| JOHNSSON, S | 1 |
| Hassouna, A | 1 |
| Loubani, M | 1 |
| Matata, BM | 1 |
| Fowler, A | 1 |
| Standen, NB | 1 |
| Galiñanes, M | 1 |
| Basabe, JC | 1 |
| Pivetta, OH | 1 |
| de Bruno, LF | 1 |
| Cresto, JC | 1 |
| Aparicio, NJ | 1 |
| Taylon, A | 1 |
| Blackard, WG | 1 |
| Andreoli, SP | 1 |
| Bergstein, JM | 1 |
| Sato, Y | 2 |
| Aizawa, T | 2 |
| Taguchi, N | 2 |
| Ishihara, F | 2 |
| Hashizume, K | 2 |
| Nakabayashi, T | 1 |
| Kobuchi, H | 1 |
| Hidaka, H | 1 |
| Nagasawa, T | 1 |
| Itoh, N | 1 |
| Leibowitz, G | 1 |
| Glaser, B | 1 |
| Higazi, AA | 1 |
| Salameh, M | 1 |
| Cerasi, E | 1 |
| Landau, H | 1 |
| Zhou, YP | 1 |
| Cockburn, BN | 1 |
| Pugh, W | 1 |
| Polonsky, KS | 1 |
| Surwit, RS | 1 |
| Dixon, TM | 1 |
| Petro, AE | 1 |
| Daniel, KW | 1 |
| Collins, S | 1 |
| Christesen, HB | 1 |
| Jacobsen, BB | 1 |
| Odili, S | 1 |
| Buettger, C | 1 |
| Cuesta-Munoz, A | 1 |
| Hansen, T | 1 |
| Brusgaard, K | 1 |
| Massa, O | 1 |
| Magnuson, MA | 1 |
| Shiota, C | 1 |
| Matschinsky, FM | 1 |
| Barbetti, F | 1 |
| Greenwood, RH | 2 |
| Mahler, RF | 2 |
| Hales, CN | 3 |
| Mirouze, J | 2 |
| Monnier, L | 2 |
| Olivier, C | 1 |
| Greenglass, EJ | 1 |
| Martin, JM | 1 |
| Burgess, JA | 1 |
| Gossain, VV | 1 |
| Werk, EE | 1 |
| Sholiton, LJ | 1 |
| Srivastava, L | 1 |
| Knowles, HC | 1 |
| Vlahos, WD | 1 |
| Seemayer, TA | 1 |
| Yale, JF | 1 |
| Wolff, F | 1 |
| Grant, A | 1 |
| Wales, J | 1 |
| Viktora, J | 1 |
| Yoshinaga, T | 1 |
| Loubatières, A | 1 |
| Mariani, MM | 1 |
| Alric, R | 1 |
| Houareau, MH | 1 |
| Culbert, S | 1 |
| Sharp, R | 1 |
| Rogers, M | 1 |
| Felts, P | 1 |
| Burr, IM | 1 |
| Graber, AL | 2 |
| Porte, D | 2 |
| Williams, RH | 2 |
| Mengoli, L | 1 |
| Le Quesne, LP | 1 |
| Bleicher, SJ | 1 |
| Chowdhury, F | 1 |
| Podolsky, S | 1 |
| Fleishman, P | 1 |
| Goldner, MG | 1 |
| Steinke, J | 1 |
| Soeldner, JS | 1 |
| Wegienka, LC | 1 |
| Simpson, RG | 1 |
| Karam, JH | 1 |
| Forsham, PH | 1 |
| Dulin, WE | 1 |
| Wyse, BM | 1 |
| Barjon, P | 1 |
| Fourcade, J | 1 |
| Mimran, A | 1 |
| Taib, J | 1 |
| Káldor, A | 1 |
| Moses, AM | 1 |
| Miller, M | 1 |
| Maclaren, NK | 1 |
| Cornblath, M | 1 |
| Jaffiol, C | 1 |
| Mary, P | 1 |
| Romanoff, NE | 1 |
| Loubatières, AL | 1 |
| Milner, RD | 1 |
| Taylor, KW | 1 |
| Müller, WA | 1 |
| Faloona, GR | 1 |
| Unger, RH | 1 |
| Malaisse, W | 1 |
| Malaisse-Lagae, F | 1 |
| Söling, HD | 1 |
| Unger, KO | 1 |
| Zahnd, GR | 1 |
| Luyckx, A | 1 |
| Senft, G | 1 |
| Seltzer, HS | 1 |
| Allen, EW | 1 |
| Villani, FJ | 1 |
| Wefer, EA | 1 |
| Mann, TA | 1 |
| Ellis, CA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Assessment of the Treatment With Diazoxide in Children Suffering From Obesity and Hyperinsulinemia Secondary to Surgery of Hypothalamic-pituitary Lesions[NCT00306683] | Phase 3 | 40 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for diazoxide and Diabetes Mellitus
| Article | Year |
|---|---|
Drug-induced dilutional hyponatremia.
Topics: Acetaminophen; Amitriptyline; Animals; Anura; Body Fluids; Carbamazepine; Chlorpropamide; Clofibrate | 1974 |
Factors controlling release of insulin from beta cell in relation to diabetes mellitus.
Topics: Amino Acids; Animals; Catecholamines; Diabetes Mellitus; Diazoxide; Glucagon; Glucose; Hexoses; Huma | 1968 |
The mechanism of insulin secretion studied through the effects of electrolytes and inhibitors.
Topics: Animals; Calcium; Diabetes Mellitus; Diazoxide; Enzyme Induction; Epinephrine; Glucagon; Hypoxia; In | 1970 |
4 trials available for diazoxide and Diabetes Mellitus
| Article | Year |
|---|---|
Diazoxide in Children With Obesity After Hypothalamic-Pituitary Lesions: A Randomized, Placebo-Controlled Trial.
Topics: Adolescent; Child; Diabetes Mellitus; Diazoxide; Double-Blind Method; Humans; Hyperinsulinism; Hypog | 2016 |
Improved beta cell function after short-term treatment with diazoxide in obese subjects with type 2 diabetes.
Topics: Antihypertensive Agents; Blood Glucose; C-Peptide; Cholesterol; Cholesterol, LDL; Diabetes Mellitus; | 2002 |
The effects of KATP channel modulators on counterregulatory responses and cognitive function during acute controlled hypoglycaemia in healthy men: a pilot study.
Topics: Adenosine Triphosphate; Adult; Blood Glucose; Cognition; Diabetes Mellitus; Diazoxide; Glucose Clamp | 2003 |
Improvement in insulin secretion in diabetes after diazoxide.
Topics: Administration, Oral; Blood Glucose; Diabetes Mellitus; Diazoxide; Glucagon; Humans; Injections, Int | 1976 |
45 other studies available for diazoxide and Diabetes Mellitus
| Article | Year |
|---|---|
Methods for Characterizing Disease-Associated ATP-Sensitive Potassium Channel Mutations.
Topics: Animals; Blotting, Western; Chlorocebus aethiops; Congenital Hyperinsulinism; COS Cells; Diabetes Me | 2018 |
Clinical characteristics and long-term outcome of Taiwanese children with congenital hyperinsulinism.
Topics: Age of Onset; Congenital Hyperinsulinism; Diabetes Mellitus; Diazoxide; Female; Follow-Up Studies; G | 2016 |
Hyperinsulinemic hypoglycemia evolving to gestational diabetes and diabetes mellitus in a family carrying the inactivating ABCC8 E1506K mutation.
Topics: Adult; ATP-Binding Cassette Transporters; Child; Congenital Hyperinsulinism; Diabetes Mellitus; Diab | 2010 |
CONJOINT CLINIC ON DRUGS AND DIABETES.
Topics: Adrenalectomy; Antihypertensive Agents; Benzothiadiazines; Biomedical Research; Blood; Blood Glucose | 1964 |
[INSULOMA TREATED WITH DIAZOXIDE].
Topics: Adenoma, Islet Cell; Antihypertensive Agents; Chlorthalidone; Diabetes Mellitus; Diazoxide; Geriatri | 1965 |
Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium.
Topics: Adenosine; Adrenergic alpha-Agonists; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitu | 2006 |
A temporal study of somatostatin secretion and its inhibitory effect in genetically diabetic mice (C57BL/KsJ-db/db).
Topics: Aging; Animals; Diabetes Mellitus; Diazoxide; Glucose; In Vitro Techniques; Insulin; Insulin Secreti | 1983 |
Role of insulin receptors in obesity-related diabetes.
Topics: Adult; Diabetes Mellitus; Diazoxide; Female; Humans; Insulin; Middle Aged; Monocytes; Obesity; Recep | 1982 |
Development of insulin-dependent diabetes mellitus during the hemolytic-uremic syndrome.
Topics: Blood Glucose; Child; Child, Preschool; Diabetes Mellitus; Diabetic Ketoacidosis; Diazoxide; Female; | 1982 |
Glucose-induced insulin release by pancreatic islets is enhanced in rats with naturally occurring obese non-insulin-dependent diabetes.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diazoxide; Diuretics; Glucose; Glucose Tolera | 1995 |
Prophylaxis of genetically determined diabetes by diazoxide: a study in a rat model of naturally occurring obese diabetes.
Topics: Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diazoxide; Di | 1995 |
Hyperinsulinemic hypoglycemia of infancy (nesidioblastosis) in clinical remission: high incidence of diabetes mellitus and persistent beta-cell dysfunction at long-term follow-up.
Topics: Adolescent; C-Peptide; Child; Diabetes Mellitus; Diazoxide; Female; Follow-Up Studies; Glucose Toler | 1995 |
Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism.
Topics: Animals; Blood Glucose; Calcium Channel Blockers; Diabetes Mellitus; Diazoxide; Enzyme Inhibitors; G | 1999 |
Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes.
Topics: Adipocytes; Adipose Tissue; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diazoxide; Diet; | 2000 |
The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.
Topics: Adolescent; Allosteric Regulation; Diabetes Mellitus; Diazoxide; Enzyme Activation; Glucokinase; Glu | 2002 |
Diazoxide, glipizide, and hypoglycaemia.
Topics: Blood Glucose; Diabetes Mellitus; Diazoxide; Drug Antagonism; Glipizide; Humans; Hypoglycemia; Insul | 1977 |
Study of renal functions by repeated constant infusion of radiotracers before and after initiation of therapy in hypertension or in diabetes mellitus.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Clonidine; Diabetes Mellitus; Diazoxide; Huma | 1975 |
Long-term function of isotransplanted islets of Langerhans in the diabetic rat.
Topics: Animals; Arginine; Blood Glucose; Body Weight; Diabetes Mellitus; Diazoxide; Disease Models, Animal; | 1976 |
Drugs which cause diabetes.
Topics: Clonidine; Contraceptives, Oral; Diabetes Mellitus; Diazoxide; Diuretics; Female; Glucocorticoids; H | 1976 |
Plasma renin activity in juvenile diabetes mellitus and effect of diazoxide.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diazoxid | 1975 |
Diabetes prevention in BB rats by inhibition of endogenous insulin secretion.
Topics: Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus; Diazoxide; Glucose Tolerance Test; | 1991 |
Experimental diabetes due to insulin inhibition.
Topics: Animals; Chlorothiazide; Diabetes Mellitus; Diazoxide; Haplorhini; Hyperglycemia; Hypoglycemia; Insu | 1968 |
[A morphological study on the mechanism of insulin-release, using sulfonylurea, l-leucine, and alpha-ketocarboxylic acids].
Topics: Animals; Blood Glucose; Butyrates; Chlorpropamide; Diabetes Mellitus; Diazoxide; Ferredoxins; Histoc | 1968 |
[Study in rats of the development of the islands of Langerhans under the effect of the chronic administration, separate or combined, of tolbutamide and diazoxide].
Topics: Animals; Diabetes Mellitus; Diazoxide; Drug Antagonism; Female; Islets of Langerhans; Rats; Tolbutam | 1968 |
Diazoxide modification of streptozotocin-induced diabetes in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diazoxide; Glucose Tolerance Test; Injections, Intraperit | 1974 |
Clinical use of diazoxide and mechanism for its hyperglycemic effects.
Topics: Adenoma, Islet Cell; Adult; Benzothiadiazines; Blood Glucose; Diabetes Mellitus; Diazoxide; Epinephr | 1966 |
Blind pancreatic resection for suspected insulinoma: a review of the problem.
Topics: Adenoma; Adenoma, Islet Cell; Adult; Aged; Diabetes Mellitus; Diazoxide; Female; Humans; Hypoglycemi | 1967 |
Studies on diazoxide-induced hyperglycemia: an extrapancreatic mechanism.
Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; Child; Coloring Agents; Diabetes Mellitus; Diabetes | 1968 |
Clinical use of diazoxide and studies of the mechanism of its hyperglycemic effects in man.
Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Diabetes Mellitus; Diazoxide; Fatty Acids, Nonesterified; | 1968 |
Metabolic effects of diazoxide in normal subjects, patients with diabetes mellitus, and patients with organic hypoglycemia.
Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; Diabetes Mellitus; Diazoxide; Fatty Acids, Nonester | 1968 |
Clinical experience with diazoxide.
Topics: Adenoma, Islet Cell; Adrenal Glands; Adult; Aged; Benzothiadiazines; Blood Glucose; Diabetes Mellitu | 1968 |
Studies on the ability of compounds to block the diabetogenic activity of streptozotocin.
Topics: Amino Acids; Animals; Diabetes Mellitus; Diaphragm; Diazoxide; Epinephrine; Ethanol; Glucosamine; Gl | 1969 |
[Hyperglycemic coma without keto-acidosis in 2 hypertensive patients treated with intravenous diazoxide].
Topics: Aged; Diabetes Complications; Diabetes Mellitus; Diabetic Coma; Diazoxide; Female; Humans; Hyperglyc | 1973 |
Side effects of some non-antibacterial sulfonamide derivatives.
Topics: Acidosis; Animals; Carbutamide; Diabetes Mellitus; Diazoxide; Diuretics; Drug Synergism; Ethanol; Gl | 1974 |
Insulin.
Topics: Adolescent; Diabetes Mellitus; Diazoxide; History, 17th Century; History, 20th Century; History, Anc | 1974 |
[Extragonadal endocrine manifestations of Klinefelter's disease].
Topics: Adrenal Gland Diseases; Adult; Antibodies; Autoantibodies; Blood Glucose; Diabetes Mellitus; Diazoxi | 1973 |
Complementary arguments in favor of the betacytotrophic action of the hypglycemic sulfonamides.
Topics: Animals; Diabetes Mellitus; Diazoxide; Dogs; Glucose; Hyperplasia; Hypoglycemia; Hypoglycemic Agents | 1970 |
Diabetes: underlying biochemical lesions.
Topics: Diabetes Mellitus; Diazoxide; Epinephrine; Female; Growth Hormone; Humans; Hyperglycemia; Insulin; I | 1970 |
The effect of experimental insulin deficiency on glucagon secretion.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diazoxide; Dogs; Glucagon; Heptoses; He | 1971 |
[Experimental diabetes induced with chemical agents].
Topics: Alloxan; Anti-Bacterial Agents; Ascorbic Acid; Diabetes Mellitus; Diazoxide; Disaccharides; Epinephr | 1972 |
The role of insulin in the regulation of -amylase synthesis in the rat pancreas.
Topics: Adrenalectomy; Amino Sugars; Amylases; Animals; Anti-Bacterial Agents; Chymotrypsin; Dactinomycin; D | 1972 |
[Diabetogenic activity of diazoxide].
Topics: Diabetes Mellitus; Diazoxide; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Insulin Secret | 1966 |
[Disorders of carbohydrate metabolism following diuretically effective agents].
Topics: Arteriosclerosis; Carbohydrate Metabolism; Chlorothiazide; Diabetes Mellitus; Diazoxide; Furosemide; | 1967 |
Hyperglycemia and inhibition of insulin secretion during administration of diazoxide and trichlormethiazide in man.
Topics: Blood Glucose; Diabetes Mellitus; Diazoxide; Drug Synergism; Glucose Tolerance Test; Humans; Hypergl | 1969 |
Derivatives of 2-azabicyclo[2.2.2]octane. 3. Substituted phenylsulfonylcarbamoyl derivatives.
Topics: Alkanes; Animals; Blood Glucose; Bridged-Ring Compounds; Chemical Phenomena; Chemistry; Diabetes Mel | 1969 |