diazoxide has been researched along with Degenerative Diseases, Central Nervous System in 2 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diazoxide treatment attenuated the NMDA-induced hippocampal injury in rats, as demonstrated by decreases in the size of the lesion, neuronal loss and microglial reaction." | 1.43 | Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus. ( Andrade, C; Batlle, M; Gimeno-Bayón, J; Mahy, N; Martínez-Moreno, M; Ortega, FJ; Rodríguez, MJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Virgili, N | 1 |
| Mancera, P | 1 |
| Wappenhans, B | 1 |
| Sorrosal, G | 1 |
| Biber, K | 1 |
| Pugliese, M | 1 |
| Espinosa-Parrilla, JF | 1 |
| Martínez-Moreno, M | 1 |
| Batlle, M | 1 |
| Ortega, FJ | 1 |
| Gimeno-Bayón, J | 1 |
| Andrade, C | 1 |
| Mahy, N | 1 |
| Rodríguez, MJ | 1 |
2 other studies available for diazoxide and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
K(ATP) channel opener diazoxide prevents neurodegeneration: a new mechanism of action via antioxidative pathway activation.
Topics: Animals; Antioxidants; Cell Line; Cell Survival; Cerebellum; Diazoxide; Dose-Response Relationship, | 2013 |
Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus.
Topics: Administration, Oral; Animals; Astrocytes; Diazoxide; Disease Models, Animal; Doublecortin Protein; | 2016 |