Page last updated: 2024-10-25

diazoxide and Degenerative Diseases, Central Nervous System

diazoxide has been researched along with Degenerative Diseases, Central Nervous System in 2 studies

Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.

Research Excerpts

ExcerptRelevanceReference
"Diazoxide treatment attenuated the NMDA-induced hippocampal injury in rats, as demonstrated by decreases in the size of the lesion, neuronal loss and microglial reaction."1.43Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus. ( Andrade, C; Batlle, M; Gimeno-Bayón, J; Mahy, N; Martínez-Moreno, M; Ortega, FJ; Rodríguez, MJ, 2016)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Virgili, N1
Mancera, P1
Wappenhans, B1
Sorrosal, G1
Biber, K1
Pugliese, M1
Espinosa-Parrilla, JF1
Martínez-Moreno, M1
Batlle, M1
Ortega, FJ1
Gimeno-Bayón, J1
Andrade, C1
Mahy, N1
Rodríguez, MJ1

Other Studies

2 other studies available for diazoxide and Degenerative Diseases, Central Nervous System

ArticleYear
K(ATP) channel opener diazoxide prevents neurodegeneration: a new mechanism of action via antioxidative pathway activation.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Animals; Antioxidants; Cell Line; Cell Survival; Cerebellum; Diazoxide; Dose-Response Relationship,

2013
Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus.
    Neuroscience, 2016, 10-01, Volume: 333

    Topics: Administration, Oral; Animals; Astrocytes; Diazoxide; Disease Models, Animal; Doublecortin Protein;

2016