diazoxide has been researched along with Compensatory Hyperinsulinemia in 206 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diazoxide is the first line and only Federal Drug Agency approved pharmacological agent for the treatment of hyperinsulinism." | 9.30 | Rate of Serious Adverse Events Associated with Diazoxide Treatment of Patients with Hyperinsulinism. ( Hamby, T; Nedrelow, J; Reynolds, C; Thornton, P; Truong, L, 2019) |
| "Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men." | 9.27 | High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018) |
| "We conducted a pilot project to test the hypothesis that decreasing insulin concentrations with diazoxide would affect parameters of vitamin D in obese women with and without polycystic ovary syndrome (PCOS)." | 9.16 | A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome. ( Bachmann, LM; Cheang, KI; Downs, RW; Nestler, JE; Reilly, ER, 2012) |
| " The aim of the present study was to investigate the effect of inhibition of insulin secretion by diazoxide on weight loss in obese, normoglycaemic (fasting plasma glucose of > or =6." | 9.12 | No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet. ( Astrup, A; Due, A; Eriksen, G; Flint, A; Hansen, JB; Møller, B; Raben, A, 2007) |
| "Diazoxide is the first-line drug for treating hyperinsulinism and the only pharmacological agent approved for hyperinsulinism by the Federal Drug Administration." | 9.12 | Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis. ( Chen, X; Feng, L; Qin, Y; Yang, L; Yao, H, 2021) |
| "Patients with the most common and severe form of diazoxide-unresponsive congenital hyperinsulinism (HI) require a pancreatectomy." | 8.31 | Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism. ( Axelrod, F; Chai, J; Challocombe, Z; Chan, KY; De León, DD; Haas, N; Han, Z; Holliday, C; Hu, CF; Juliana, CA; Lujan Hernandez, AG; Peterson, SM; Sato, AK; Stafford, R; Wang, L; Yuan, TZ, 2023) |
| "The aim of the study was to characterize factors that may serve as clinical tools to identify neonates with transient neonatal hyperinsulinism hypoglycemia (HH) who may benefit from diazoxide treatment." | 7.96 | Higher C-peptide levels and glucose requirements may identify neonates with transient hyperinsulinism hypoglycemia who will benefit from diazoxide treatment. ( Davidov, AS; Elkon-Tamir, E; Eyal, O; Haham, A; Lebenthal, Y; Mandel, D; Oren, A; Shefer, G; Weintrob, N, 2020) |
| "The diagnosis of hypoglycemia and the use of diazoxide have risen in the last decade." | 7.96 | Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism. ( Brar, PC; Cossen, K; De Leon, DD; Heksch, R; Kamboj, MK; Marks, SD; Marshall, BA; Miller, R; Mitchell, D; Page, L; Stanley, T; Thornton, P, 2020) |
| "Diazoxide is the main therapeutic agent for persistent hyperinsulinemic hypoglycemia." | 7.77 | Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide. ( Arasli, A; Çetin, II; Demirel, F; Esen, I; Unal, S, 2011) |
| "Recessive mutations in the hydroxyacyl-CoA dehydrogenase (HADH) gene encoding the enzyme 3-hydroxyacyl-CoA dehydrogenase are a rare cause of diazoxide-responsive hyperinsulinemic hypoglycemia (HH) with just five probands reported to date." | 7.77 | Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees. ( Akcay, T; Alaei, M; Desai, M; Ellard, S; Flanagan, SE; Hussain, K; Kapoor, RR; Locke, JM; Patch, AM; Simsek, E; Yekta, Z, 2011) |
| "The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY)." | 7.76 | Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. ( Akcay, T; Banerjee, I; Cody, D; Ellard, S; Flanagan, SE; Hussain, K; Kapoor, RR; Mali, G; Murphy, N; Rubio-Cabezas, O; Schwahn, B; Shield, JP; Siahanidou, T, 2010) |
| "Diazoxide is commonly used in the treatment of neonatal hyperinsulinism." | 7.74 | Development of pulmonary hypertension in an infant treated with diazoxide. ( Caldwell, RL; Eugster, EA; Hoover, WC; Nebesio, TD; Nitu, ME, 2007) |
| "To test the hypothesis that insulin plays a role in the hyperandrogenism of obese women with polycystic ovary syndrome, we conducted a prospective study in which the androgen status of five obese women with polycystic ovary syndrome was assessed on two occasions: before and after 10 days of oral diazoxide (100 mg, three times daily) administration." | 7.67 | Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. ( Barlascini, CO; Blackard, WG; Clore, JN; Matt, DW; Nestler, JE; Plymate, SR; Steingold, KA, 1989) |
| " The most common adverse events were peripheral edema and transient increases in glucose." | 6.90 | A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome. ( Cowen, NM; Gold, JA; Kimonis, V; Surampalli, A; Wencel, M, 2019) |
| "What is Known: • Congenital hyperinsulinism (CHI) or persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI) associated with mutations such as the ABBC8 or KCNJ gene known to cause hypoglycaemia refractory to standard medical treatment such as diazoxide and octreotide and may need subtotal pancreatectomy (STP)." | 5.72 | Sirolimus in infants with congenital hyperinsulinism (CHI) - a single-centre experience. ( Bagga, N; Chirla, DK; Gunda, RK; Panigrahy, N; Reddy, L; Sukhija, B, 2022) |
| "Hereditary tyrosinemia (HT1) is a rare metabolic disorder associated with accumulation of toxic metabolites of the tyrosine pathway due to a genetically mediated enzyme defect of fumarylacetoacetate hydrolase." | 5.62 | Neonatal hyperinsulinism in transient and classical forms of tyrosinemia. ( Gujral, J; Romero, CJ; Sethuram, S; Sperling, MA, 2021) |
| "Diazoxide is a non-diuretic benzothiadiazine derivative, one of a group of substances introduced into clinical practice in the 1950s for the treatment of hypertension." | 5.43 | Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( Inoue, Y; Komatsu, Y; Miyoshi, H; Nakamura, A; Tajima, K; Takano, T; Takihata, M; Terauchi, Y; Tsuchiya, H; Yahagi, S; Yamakawa, T; Yoshida, M, 2016) |
| "The cause of the hyperinsulinemia proved to be classical Munchausen by proxy." | 5.36 | Anemia and neutropenic fever with high dose diazoxide treatment in a case with hyperinsulinism due to Munchausen by proxy. ( Demirbilek, H; Ertugrul, A; Gumruk, F; Kandemir, N; Ozon, A; Unal, S, 2010) |
| "This syndrome is caused by dominantly expressed mutations of the glutamate dehydrogenase gene (10q23." | 5.32 | [Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide]. ( Argente Oliver, J; Donoso, MA; Martos Moreno, G; Montero Luis, C; Muñoz Calvo, MT; Pozo Román, J; Rubio Cabezas, O, 2004) |
| "Diazoxide is the first line and only Federal Drug Agency approved pharmacological agent for the treatment of hyperinsulinism." | 5.30 | Rate of Serious Adverse Events Associated with Diazoxide Treatment of Patients with Hyperinsulinism. ( Hamby, T; Nedrelow, J; Reynolds, C; Thornton, P; Truong, L, 2019) |
| "Cardiorespiratory failure (toxicity) occurred on eight of the 11 occasions (73%) in seven infants." | 5.28 | Complications of diazoxide treatment in persistent neonatal hyperinsulinism. ( Abu-Osba, YK; Manasra, KB; Mathew, PM, 1989) |
| "Diazoxide (10 mg/kg/d) was successful in controlling hypoglycemia for eight years and one year, respectively, without serious side effects." | 5.27 | Persistent neonatal hyperinsulinemic hypoglycemia in two siblings successfully treated with diazoxide. ( Schubiger, G; Wüthrich, C; Zuppinger, K, 1986) |
| "Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men." | 5.27 | High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018) |
| "We conducted a pilot project to test the hypothesis that decreasing insulin concentrations with diazoxide would affect parameters of vitamin D in obese women with and without polycystic ovary syndrome (PCOS)." | 5.16 | A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome. ( Bachmann, LM; Cheang, KI; Downs, RW; Nestler, JE; Reilly, ER, 2012) |
| " The aim of the present study was to investigate the effect of inhibition of insulin secretion by diazoxide on weight loss in obese, normoglycaemic (fasting plasma glucose of > or =6." | 5.12 | No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet. ( Astrup, A; Due, A; Eriksen, G; Flint, A; Hansen, JB; Møller, B; Raben, A, 2007) |
| "Diazoxide is the first-line drug for treating hyperinsulinism and the only pharmacological agent approved for hyperinsulinism by the Federal Drug Administration." | 5.12 | Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis. ( Chen, X; Feng, L; Qin, Y; Yang, L; Yao, H, 2021) |
| " Persistent hyperinsulinism was only described in two siblings and responded to diazoxide treatment." | 5.12 | Expanding the spectrum of endocrinopathies identified in Schaaf-Yang syndrome - A case report and review of the literature. ( Cohen, M; Ekhilevitch, N; Habib, C; Halloun, R; Tiosano, D; Weiss, R, 2021) |
| "Given that reports on severe diazoxide (DZX) toxicity are increasing, we aimed to understand if the short-term clinical outcomes of small-for-gestational-age (SGA) infants with hyperinsulinemic hypoglycemia (HH) managed primarily by supportive care, termed watchful waiting (WW), are different from those treated with DZX." | 4.31 | Watchful waiting versus pharmacological management of small-for-gestational-age infants with hyperinsulinemic hypoglycemia. ( Chandran, S; Chua, MC; Jaya-Bodestyne, SL; Rajadurai, VS; Saffari, SE; Yap, F, 2023) |
| "Patients with the most common and severe form of diazoxide-unresponsive congenital hyperinsulinism (HI) require a pancreatectomy." | 4.31 | Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism. ( Axelrod, F; Chai, J; Challocombe, Z; Chan, KY; De León, DD; Haas, N; Han, Z; Holliday, C; Hu, CF; Juliana, CA; Lujan Hernandez, AG; Peterson, SM; Sato, AK; Stafford, R; Wang, L; Yuan, TZ, 2023) |
| "The diagnosis of hypoglycemia and the use of diazoxide have risen in the last decade." | 3.96 | Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism. ( Brar, PC; Cossen, K; De Leon, DD; Heksch, R; Kamboj, MK; Marks, SD; Marshall, BA; Miller, R; Mitchell, D; Page, L; Stanley, T; Thornton, P, 2020) |
| "The aim of the study was to characterize factors that may serve as clinical tools to identify neonates with transient neonatal hyperinsulinism hypoglycemia (HH) who may benefit from diazoxide treatment." | 3.96 | Higher C-peptide levels and glucose requirements may identify neonates with transient hyperinsulinism hypoglycemia who will benefit from diazoxide treatment. ( Davidov, AS; Elkon-Tamir, E; Eyal, O; Haham, A; Lebenthal, Y; Mandel, D; Oren, A; Shefer, G; Weintrob, N, 2020) |
| "The authors report a macrosomic term male infant who developed refractory hyperinsulinism requiring 20 mg/kg/min intravenous dextrose (usual range 4-6 mg/kg/min) and treatment with diazoxide 10 mg/kg/day." | 3.77 | Neonatal hyperinsulinism secondary to maternal intake of high-sugar drinks. ( Thorpe, M; West, NJ, 2011) |
| "Recessive mutations in the hydroxyacyl-CoA dehydrogenase (HADH) gene encoding the enzyme 3-hydroxyacyl-CoA dehydrogenase are a rare cause of diazoxide-responsive hyperinsulinemic hypoglycemia (HH) with just five probands reported to date." | 3.77 | Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees. ( Akcay, T; Alaei, M; Desai, M; Ellard, S; Flanagan, SE; Hussain, K; Kapoor, RR; Locke, JM; Patch, AM; Simsek, E; Yekta, Z, 2011) |
| "Diazoxide is the main therapeutic agent for persistent hyperinsulinemic hypoglycemia." | 3.77 | Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide. ( Arasli, A; Çetin, II; Demirel, F; Esen, I; Unal, S, 2011) |
| "The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY)." | 3.76 | Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. ( Akcay, T; Banerjee, I; Cody, D; Ellard, S; Flanagan, SE; Hussain, K; Kapoor, RR; Mali, G; Murphy, N; Rubio-Cabezas, O; Schwahn, B; Shield, JP; Siahanidou, T, 2010) |
| "These results confirm the potency of glucokinase as the pancreatic beta-cell glucose sensor, and they demonstrate that responsiveness to diazoxide varies with genotype in glucokinase hyperinsulinism resulting in hypoglycemia, which can be more difficult to control than previously believed." | 3.75 | Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations. ( Buettger, C; Chen, P; Grimsby, J; Langdon, DR; Matschinsky, FM; Odili, S; Sayed, S; Schiffman, AB; Stanley, CA; Suchi, M; Taub, R, 2009) |
| " Ovariectomized, steroid-replaced rats were fitted with indwelling jugular catheters and infused for 48 h with saline, glucose (hyperglycemia-hyperinsulinemia), insulin and glucose (hyperinsulinemia), diazoxide (control), or glucose and diazoxide (hyperglycemia)." | 3.74 | Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats. ( Acosta-Martínez, M; Levine, JE, 2007) |
| "Diazoxide is commonly used in the treatment of neonatal hyperinsulinism." | 3.74 | Development of pulmonary hypertension in an infant treated with diazoxide. ( Caldwell, RL; Eugster, EA; Hoover, WC; Nebesio, TD; Nitu, ME, 2007) |
| "We define a syndrome of prolonged neonatal hyperinsulinism that is responsive to diazoxide, persists for several months, and resolves spontaneously." | 3.73 | Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism. ( Hoe, FM; Simmons, RA; Stanley, CA; Steinkrauss, L; Thornton, PS; Wanner, LA, 2006) |
| "Serum concentrations of pancreatic glucagon were measured in 40 patients with hyperinsulinemic hypoglycemia." | 3.69 | Pancreatic glucagon levels in infants and children with hyperinsulinemia. ( Cedro, A; Gruszczyńska, B; Kamiński, W; Leśniewska, A; Pronicka, E; Woźniewicz, B, 1995) |
| "Organic hyperinsulinism is treated as a rule conservatively with diazoxide (Proglicem) which has a hyperglycaemic effect." | 3.69 | [The effect of Proglicem in patients with an organic hyperinsulinism syndrome]. ( Justová, V; Sindelka, G; Skrha, J; Svacina, S; Wichterle, D, 1994) |
| " A mutation in the second nucleotide-binding fold (NBF2) of the sulfonylurea receptor (SUR) of an individual diagnosed with persistent hyperinsulinemic hypoglycemia of infancy generated KATP channels that could be opened by diazoxide but not in response to metabolic inhibition." | 3.69 | Adenosine diphosphate as an intracellular regulator of insulin secretion. ( Aguilar-Bryan, L; Bryan, J; Clement, JP; Glaser, B; Gonzalez, G; Nestorowicz, A; Nichols, CG; Permutt, MA; Shyng, SL, 1996) |
| "The suppression of hyperinsulinism with diazoxide (300 mg/d during 30 days) in a young woman with PCOS and hirsutism, hyperinsulinism and insulinoresistance was followed by a modification of plasma androgens." | 3.69 | [Polycystic ovary and diazoxide. In vivo study]. ( Bercovici, JP; Brettes, JP; Floch, HH; Monguillon, P; Nahoul, K, 1996) |
| " Following diagnosis of hyperinsulinemic hypoglycemia, this patient was treated with oral diazoxide." | 3.68 | Prenatal diagnosis of familial neonatal hyperinsulinemia. ( Aparicio, L; Carpenter, MW; Gruppuso, PA; Schwartz, R, 1993) |
| "To test the hypothesis that insulin plays a role in the hyperandrogenism of obese women with polycystic ovary syndrome, we conducted a prospective study in which the androgen status of five obese women with polycystic ovary syndrome was assessed on two occasions: before and after 10 days of oral diazoxide (100 mg, three times daily) administration." | 3.67 | Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. ( Barlascini, CO; Blackard, WG; Clore, JN; Matt, DW; Nestler, JE; Plymate, SR; Steingold, KA, 1989) |
| "Hyperinsulinemic hypoglycemia secondary to nesidioblastosis persisted in a 4-year-old girl despite a 95% pancreatectomy and high-dose diazoxide treatment." | 3.66 | Persistent leucine sensitivity following partial pancreatectomy and diazoxide treatment. Therapeutic response. ( Bradvica, C; Golden, MP; Graham, MJ; Santiago, J; Sargeant, DT; White, NH; Zuniga, O, 1983) |
| "In two children treated for hypoglycemia and convulsions with diazoxide and diphenylhydantoin, therapeutic serum diphenylhydantoin levels were not achieved despite doses of diphenylhydantoin of 17 and 29 mg/kg/day, respectively." | 3.65 | Drug interaction: diazoxide and diphenylhydantoin. ( Blaskovics, ME; Podosin, RL; Roe, TF, 1975) |
| " The most common adverse events were peripheral edema and transient increases in glucose." | 2.90 | A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome. ( Cowen, NM; Gold, JA; Kimonis, V; Surampalli, A; Wencel, M, 2019) |
| "The role of hyperinsulinemia as a possible preceding event in the development of obesity has been proposed." | 2.69 | Beneficial effect of diazoxide in obese hyperinsulinemic adults. ( Alemzadeh, R; Langley, G; Slonim, AE; Smith, P; Upchurch, L, 1998) |
| "Neonatal hypoglycemia is one of the most common biochemical abnormalities encountered in the newborn." | 2.50 | Update on neonatal hypoglycemia. ( Rozance, PJ, 2014) |
| "Initial interventions for hyperinsulinemia are conservative." | 2.41 | When it is more than transient neonatal hypoglycemia: hyperinsulinemia--a case study challenge. ( Shirland, L, 2001) |
| "Hyperinsulinism is a heterogeneous disorder characterised by severe hypoglycaemia due to an inappropriate oversecretion of insulin." | 2.41 | Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases. ( Bellane-Chantelot, C; Brunelle, F; Brusset, MC; Chigot, V; de Lonlay, P; Delagne, V; Fournet, JC; Groos, MS; Junien, C; Laborde, K; Martin, D; Mayaud, C; Nihoul-Fékété, C; Rahier, J; Robert, JJ; Saudubray, JM; Sempoux, C; Sevin, C; Touati, G; Vassault, A, 2002) |
| "Hyperinsulinism is the most common cause of hypoglycemia in early infancy." | 2.40 | Hyperinsulinism in infants and children. ( Stanley, CA, 1997) |
| "Hyperinsulinism was permanent in two of these three cases." | 1.72 | Hyperinsulinism May Be Underreported in Hypoglycemic Patients with Phosphomannomutase 2 Deficiency ( Alikaşifoğlu, A; Dursun, A; Gönç, N; Ozon, A; Sivri, HS; Tokatlı, A; Vurallı, D; Yıldız, Y, 2022) |
| "Diazoxide was commenced in 28 patients (82." | 1.72 | Clinical and genetic heterogeneity of HNF4A/HNF1A mutations in a multicentre paediatric cohort with hyperinsulinaemic hypoglycaemia. ( Brusgaard, K; Christesen, H; Conlon, N; Dastamani, A; Demirbilek, H; Flanagan, SE; Gubaeva, D; Houghton, JAL; McGlacken-Byrne, SM; Melikyan, M; Mohammad, JK; Murphy, NP; Schou, AJ; Shah, P; Siersbæk, J, 2022) |
| "What is Known: • Congenital hyperinsulinism (CHI) or persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI) associated with mutations such as the ABBC8 or KCNJ gene known to cause hypoglycaemia refractory to standard medical treatment such as diazoxide and octreotide and may need subtotal pancreatectomy (STP)." | 1.72 | Sirolimus in infants with congenital hyperinsulinism (CHI) - a single-centre experience. ( Bagga, N; Chirla, DK; Gunda, RK; Panigrahy, N; Reddy, L; Sukhija, B, 2022) |
| "Hypoglycemia was not repeated on endocrinological examination, even while fasting." | 1.72 | Diagnosis and Treatment Course of Insulinoma Presenting as Hypoglycemia Unawareness Using a Factory-Calibrated Continuous Glucose Monitoring System. ( Aida, A; Noto, H, 2022) |
| "Hereditary tyrosinemia (HT1) is a rare metabolic disorder associated with accumulation of toxic metabolites of the tyrosine pathway due to a genetically mediated enzyme defect of fumarylacetoacetate hydrolase." | 1.62 | Neonatal hyperinsulinism in transient and classical forms of tyrosinemia. ( Gujral, J; Romero, CJ; Sethuram, S; Sperling, MA, 2021) |
| "Diazoxide treatment for 10 days was sufficient to increase pulsatile GH secretion in DIO mice before any significant body weight change." | 1.62 | Suppression of hyperinsulinemia restores growth hormone secretion and metabolism in obese mice. ( Chen, C; Chen, Y; Huang, L; Huang, Z; Lu, X; Veldhuis, JD; Zhang, C, 2021) |
| "Transient hyperinsulinism are the most common cause of severe hypoglycemia in newborns." | 1.56 | [Transient hyperinsulinism in neonates]. ( Bockeria, EL; Bolmasova, AV; Degtyareva, AV; Ionov, OV; Krylova, NA; Melikyan, MA; Pekareva, NA; Ryumina, II, 2020) |
| "This syndrome is characterised by recurrent episodes of hypoglycaemia and elevated ammonia levels, which are potentially harmful to both the patient and a developing fetus." | 1.56 | Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome. ( Bazelmans, M; Benner, BJM; Huidekoper, H; Langendonk, J; Langeveld, M; Schoenmakers, S, 2020) |
| "Most cases of insulinomas are benign." | 1.43 | A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma. ( Berberabe, A; Pagsisihan, D; Palugod-Lopez, EG; Sandoval, MA, 2016) |
| "Diazoxide is a non-diuretic benzothiadiazine derivative, one of a group of substances introduced into clinical practice in the 1950s for the treatment of hypertension." | 1.43 | Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. ( Inoue, Y; Komatsu, Y; Miyoshi, H; Nakamura, A; Tajima, K; Takano, T; Takihata, M; Terauchi, Y; Tsuchiya, H; Yahagi, S; Yamakawa, T; Yoshida, M, 2016) |
| "Diazoxide is an effective and usually safe medication to treat this type and other types of neonatal HI." | 1.42 | Liver injury may increase the risk of diazoxide toxicity: a case report. ( Garibaldi, L; Mahmood, B; Sperling, M; Tas, E, 2015) |
| "Hyperinsulinism was diagnosed as hypoglycemia concomitant with high serum insulin in babies requiring >6 mg/kg/min intravenous glucose and THI as hyperinsulinism without maternal diabetes or genetic disorders." | 1.42 | Fetal Erythroblastosis May Be an Indicator of Neonatal Transient Hyperinsulinism. ( Hata, D; Iki, Y; Katayama, T; Kawai, M; Mizumoto, H; Yamashita, S, 2015) |
| "Glucose infusion (Hyperglycemia and hyperinsulinemia) significantly increased BDNF mRNA expression in the posterior ventromedial nucleus of the hypothalamus (pVMH) and in the dorsomedial nucleus of the hypothalamus (DMH)." | 1.42 | Prolonged hyperglycemia & hyperinsulinemia increases BDNF mRNA expression in the posterior ventromedial hypothalamus and the dorsomedial hypothalamus of fed female rats. ( Acosta-Martínez, M; Beymer, M; Negrón, AL; Warren, KA; Yu, G, 2015) |
| "The cause of the hyperinsulinemia proved to be classical Munchausen by proxy." | 1.36 | Anemia and neutropenic fever with high dose diazoxide treatment in a case with hyperinsulinism due to Munchausen by proxy. ( Demirbilek, H; Ertugrul, A; Gumruk, F; Kandemir, N; Ozon, A; Unal, S, 2010) |
| "We hypothesized that hyperinsulinemia precedes the development of insulin resistance and increased adiposity in these mice with a defective adipoinsular axis." | 1.36 | Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling. ( Covey, SD; Donald, C; Gray, SL; Jetha, A; Kieffer, TJ, 2010) |
| "Hypoglycemia has been documented due to growth hormone and cortisol deficiency." | 1.33 | Costello syndrome and hyperinsulinemic hypoglycemia. ( Al-Sharkawi, I; Alexander, S; Alkhayyat, H; Backer, KC; El-Sabban, F; Hussain, K; Ramadan, D, 2005) |
| "A common and well recognised feature of Turner's syndrome (partial or total monosomy X) is impaired glucose tolerance or type 2 diabetes mellitus." | 1.33 | Mosaic Turner syndrome and hyperinsulinaemic hypoglycaemia. ( Alkhayyat, H; Brusgaard, K; Christesen, HB; Hussain, K; Steer, J; Stewart, H, 2006) |
| "Treatment with diazoxide and chlorthiazide is highly effective, appears to be safe, and does not need to be continued lifelong." | 1.33 | Hyperinsulinism in tyrosinaemia type I. ( Baumann, U; Green, A; Kelly, DA; McKiernan, PJ; Preece, MA, 2005) |
| "Diazoxide treatment remains the mainstay of medical therapy." | 1.32 | A case of severe diazoxide toxicity. ( Camporesi, A; Mandelli, A; Salvo, I; Silvani, P; Wolfler, A, 2004) |
| "This syndrome is caused by dominantly expressed mutations of the glutamate dehydrogenase gene (10q23." | 1.32 | [Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide]. ( Argente Oliver, J; Donoso, MA; Martos Moreno, G; Montero Luis, C; Muñoz Calvo, MT; Pozo Román, J; Rubio Cabezas, O, 2004) |
| "Hyperinsulinism was diagnosed in our Clinic." | 1.31 | Neonatal hyperinsulinemic hypoglycemia. Two case reports. ( Antoniazzi, F; Maffeis, C; Tatò, L; Zaffanello, M; Zamboni, G, 2002) |
| "The hypoglycemia was refractory to high glucose delivery rates (25 mg/kg/min), but responded to a combination of octreotide and diazoxide." | 1.31 | Transient hyperinsulinism in an asphyxiated newborn infant with hypoglycemia. ( Clark, W; O'Donovan, D, 2001) |
| "Chronic attenuation of hyperinsulinemia by diazoxide (DZ), an inhibitor of glucose-mediated insulin secretion, improved insulin sensitivity and glucose tolerance and caused down-regulation of lipid metabolizing enzymes in adipose tissue and decreased the rate of weight gain in mildly hyperglycemic obese Zucker rats." | 1.31 | Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats. ( Alemzadeh, R; Holshouser, S; Koontz, J; Massey, P, 2002) |
| "Diazoxide treatment remains the mainstay of medical therapy in long-term management." | 1.30 | Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: a retrospective review of 77 cases and analysis of efficacy-predicting criteria. ( Brunelle, F; Czernichow, P; Nihoul-Fekete, C; Ogier de Baulny, H; Poggi-Travert, F; Rahier, J; Saudubray, JM; Touati, G, 1998) |
| "When treatment with diazoxide and somatostatin for persistent hyperinsulinaemic hypoglycaemia of infancy failed, subtotal pancreatectomy was performed on a neonate on day 41." | 1.30 | Histochemical, clinical, and in vitro beta cell responses in a neonate with persistent hyperinsulinaemic hypoglycaemia of infancy. ( Hjelm, NM; Liew, CT; Panesar, NS; Poon, CW; Wong, GW, 1998) |
| "Cardiorespiratory failure (toxicity) occurred on eight of the 11 occasions (73%) in seven infants." | 1.28 | Complications of diazoxide treatment in persistent neonatal hyperinsulinism. ( Abu-Osba, YK; Manasra, KB; Mathew, PM, 1989) |
| "Diazoxide was useful in the treatment of three patients but many side-effects were observed." | 1.28 | Hyperinsulinism in infancy. ( Chow, OK; Low, LC; Yeung, CY; Young, RT; Yu, EC, 1989) |
| "Diazoxide (10 mg/kg/d) was successful in controlling hypoglycemia for eight years and one year, respectively, without serious side effects." | 1.27 | Persistent neonatal hyperinsulinemic hypoglycemia in two siblings successfully treated with diazoxide. ( Schubiger, G; Wüthrich, C; Zuppinger, K, 1986) |
| "Hyperinsulinism has been postulated as a possible stimulus to somatomedin (SM) synthesis by the perfused rat liver and in man." | 1.26 | Plasma somatomedins in children with hyperinsulinism. ( Blethen, SL; Daughaday, WH; Santiago, JV; White, NH, 1981) |
| "The third has occasional fasting hypoglycemia that is treated with diazoxide; he continues to have a seizure disorder and is mentally retarded." | 1.26 | Nesidioblastosis in children. ( Danis, RK; Garvin, PJ; Knight, J; Lewis, JE; Willman, VL, 1980) |
| "Islet cell adenomas are an important consideration in infants and children with hypoglycemia due to hyperinsulinism." | 1.26 | Pancreatic adenomas in infants and children: current surgical management. ( Baker, L; Bishop, HC; Gauderer, M; Stanley, CA, 1978) |
| "A seven months old infant suffered from convulsions due to leucine-sensitive hypoglycaemia." | 1.26 | [Leucine-sensitive hypoglycaemia and its treatment with diazoxide (author's transl)]. ( Reich, H; Schünke, W, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 74 (35.92) | 18.7374 |
| 1990's | 34 (16.50) | 18.2507 |
| 2000's | 44 (21.36) | 29.6817 |
| 2010's | 34 (16.50) | 24.3611 |
| 2020's | 20 (9.71) | 2.80 |
| Authors | Studies |
|---|---|
| McGlacken-Byrne, SM | 1 |
| Mohammad, JK | 1 |
| Conlon, N | 1 |
| Gubaeva, D | 1 |
| Siersbæk, J | 1 |
| Schou, AJ | 1 |
| Demirbilek, H | 2 |
| Dastamani, A | 1 |
| Houghton, JAL | 1 |
| Brusgaard, K | 3 |
| Melikyan, M | 1 |
| Christesen, H | 1 |
| Flanagan, SE | 7 |
| Murphy, NP | 1 |
| Shah, P | 1 |
| Vurallı, D | 1 |
| Yıldız, Y | 1 |
| Ozon, A | 2 |
| Dursun, A | 1 |
| Gönç, N | 1 |
| Tokatlı, A | 1 |
| Sivri, HS | 1 |
| Alikaşifoğlu, A | 1 |
| Lemaitre, M | 1 |
| Douillard, C | 1 |
| Froguel, P | 1 |
| Bonnefond, A | 1 |
| Vambergue, A | 1 |
| Aida, A | 1 |
| Noto, H | 1 |
| De Los Santos-La Torre, MA | 2 |
| Del Águila-Villar, CM | 2 |
| Lu-de Lama, LR | 2 |
| Nuñez-Almache, O | 2 |
| Chávez-Tejada, EM | 2 |
| Espinoza-Robles, OA | 2 |
| Pinto-Ibárcena, PM | 2 |
| Calagua-Quispe, MR | 2 |
| Azabache-Tafur, PM | 2 |
| Tucto-Manchego, RM | 2 |
| Peterson, SM | 1 |
| Juliana, CA | 1 |
| Hu, CF | 1 |
| Chai, J | 1 |
| Holliday, C | 1 |
| Chan, KY | 1 |
| Lujan Hernandez, AG | 1 |
| Challocombe, Z | 1 |
| Wang, L | 1 |
| Han, Z | 1 |
| Haas, N | 1 |
| Stafford, R | 1 |
| Axelrod, F | 1 |
| Yuan, TZ | 1 |
| De León, DD | 4 |
| Sato, AK | 1 |
| Chandran, S | 2 |
| Jaya-Bodestyne, SL | 1 |
| Rajadurai, VS | 2 |
| Saffari, SE | 1 |
| Chua, MC | 1 |
| Yap, F | 1 |
| Maines, E | 1 |
| Urru, SAM | 1 |
| Leonardi, L | 1 |
| Fancellu, E | 1 |
| Campomori, A | 1 |
| Piccoli, G | 1 |
| Maiorana, A | 1 |
| Soffiati, M | 1 |
| Franceschi, R | 1 |
| Raisingani, M | 1 |
| Brar, PC | 2 |
| Arya, VB | 2 |
| Dhawan, A | 1 |
| Kapoor, RR | 4 |
| Thus, KA | 1 |
| den Boogert, WJ | 1 |
| van der Heyden, JC | 1 |
| Kimonis, V | 1 |
| Surampalli, A | 1 |
| Wencel, M | 1 |
| Gold, JA | 1 |
| Cowen, NM | 1 |
| Davidov, AS | 1 |
| Elkon-Tamir, E | 1 |
| Haham, A | 1 |
| Shefer, G | 1 |
| Weintrob, N | 1 |
| Oren, A | 1 |
| Lebenthal, Y | 1 |
| Mandel, D | 1 |
| Eyal, O | 1 |
| Brandt, A | 1 |
| Agarwal, N | 1 |
| Giri, D | 1 |
| Yung, Z | 1 |
| Didi, M | 1 |
| Senniappan, S | 2 |
| Benner, BJM | 1 |
| Bazelmans, M | 1 |
| Huidekoper, H | 1 |
| Langeveld, M | 1 |
| Langendonk, J | 1 |
| Schoenmakers, S | 1 |
| Heksch, R | 1 |
| Cossen, K | 1 |
| Kamboj, MK | 1 |
| Marks, SD | 1 |
| Marshall, BA | 1 |
| Miller, R | 1 |
| Page, L | 1 |
| Stanley, T | 1 |
| Mitchell, D | 1 |
| Thornton, P | 2 |
| Bolmasova, AV | 1 |
| Melikyan, MA | 1 |
| Krylova, NA | 1 |
| Ionov, OV | 1 |
| Ryumina, II | 1 |
| Bockeria, EL | 1 |
| Pekareva, NA | 1 |
| Degtyareva, AV | 1 |
| Chen, X | 1 |
| Feng, L | 1 |
| Yao, H | 1 |
| Yang, L | 1 |
| Qin, Y | 1 |
| Boudreau, LE | 1 |
| Padbury, JF | 1 |
| Hoermann, H | 1 |
| Roeper, M | 1 |
| Salimi Dafsari, R | 1 |
| Koestner, F | 1 |
| Reinauer, C | 1 |
| Mayatepek, E | 2 |
| Meissner, T | 2 |
| Kummer, S | 1 |
| Sethuram, S | 1 |
| Sperling, MA | 1 |
| Gujral, J | 1 |
| Romero, CJ | 1 |
| Halloun, R | 1 |
| Habib, C | 1 |
| Ekhilevitch, N | 1 |
| Weiss, R | 1 |
| Tiosano, D | 1 |
| Cohen, M | 1 |
| Huang, Z | 1 |
| Lu, X | 1 |
| Huang, L | 1 |
| Chen, Y | 1 |
| Zhang, C | 1 |
| Veldhuis, JD | 1 |
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| Panigrahy, N | 1 |
| Chirla, DK | 1 |
| Bagga, N | 1 |
| Gunda, RK | 1 |
| Sukhija, B | 1 |
| Reddy, L | 1 |
| Veiguela Blanco, B | 1 |
| Felechosa, MD | 1 |
| García Moreira, V | 1 |
| Lord, K | 1 |
| Tung, JY | 1 |
| Boodhansingh, K | 1 |
| Stanley, CA | 10 |
| Loves, S | 1 |
| van Groningen, L | 1 |
| Filius, M | 1 |
| Mekking, M | 1 |
| Brandon, T | 1 |
| Tack, CJ | 1 |
| Hermus, A | 1 |
| de Boer, H | 1 |
| Truong, L | 1 |
| Reynolds, C | 1 |
| Hamby, T | 1 |
| Nedrelow, J | 1 |
| Roy, K | 1 |
| Satapathy, AK | 1 |
| Houhton, JAL | 1 |
| Radha, V | 1 |
| Mohan, V | 1 |
| Sharma, R | 1 |
| Jain, V | 1 |
| Martínez-Ortega, AJ | 1 |
| Mangas-Cruz, MA | 1 |
| Aliaga-Verdugo, A | 1 |
| Acosta-Delgado, D | 1 |
| Ağladıoğlu, SY | 1 |
| Savaş Erdeve, S | 1 |
| Cetinkaya, S | 1 |
| Baş, VN | 1 |
| Peltek Kendirci, HN | 1 |
| Onder, A | 1 |
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| Rozance, PJ | 1 |
| Chong, JH | 1 |
| Agarwal, P | 1 |
| Blanco, M | 1 |
| Khan, O | 1 |
| Stanley, K | 1 |
| Hageman, JR | 1 |
| Greeley, SA | 1 |
| Manocha, D | 1 |
| Shah, R | 1 |
| Vaidya, GN | 1 |
| Bansal, N | 1 |
| Tas, E | 1 |
| Mahmood, B | 1 |
| Garibaldi, L | 1 |
| Sperling, M | 1 |
| Mizumoto, H | 1 |
| Iki, Y | 1 |
| Yamashita, S | 1 |
| Kawai, M | 1 |
| Katayama, T | 1 |
| Hata, D | 1 |
| Negrón, AL | 1 |
| Beymer, M | 1 |
| Yu, G | 1 |
| Warren, KA | 1 |
| Acosta-Martínez, M | 2 |
| Sadeghizadeh, A | 1 |
| Ellard, S | 5 |
| Hashemipour, M | 1 |
| Hosseinzadeh, M | 1 |
| Salehi, M | 1 |
| Hussain, K | 15 |
| Komatsu, Y | 1 |
| Nakamura, A | 1 |
| Takihata, M | 1 |
| Inoue, Y | 1 |
| Yahagi, S | 1 |
| Tajima, K | 1 |
| Tsuchiya, H | 1 |
| Takano, T | 1 |
| Yamakawa, T | 1 |
| Yoshida, M | 1 |
| Miyoshi, H | 1 |
| Terauchi, Y | 1 |
| Sandoval, MA | 1 |
| Pagsisihan, D | 1 |
| Berberabe, A | 1 |
| Palugod-Lopez, EG | 1 |
| Brauner, R | 1 |
| Serreau, R | 1 |
| Souberbielle, JC | 1 |
| Pouillot, M | 1 |
| Grouazel, S | 1 |
| Recasens, C | 1 |
| Zerah, M | 1 |
| Sainte-Rose, C | 1 |
| Treluyer, JM | 1 |
| Martínez, R | 1 |
| Gutierrez-Nogués, Á | 1 |
| Fernández-Ramos, C | 1 |
| Velayos, T | 1 |
| Vela, A | 1 |
| Navas, MÁ | 1 |
| Castaño, L | 1 |
| Sayed, S | 1 |
| Langdon, DR | 1 |
| Odili, S | 1 |
| Chen, P | 1 |
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| Schiffman, AB | 1 |
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| Spanakis, E | 1 |
| Gragnoli, C | 1 |
| Mali, G | 1 |
| Cody, D | 1 |
| Murphy, N | 1 |
| Schwahn, B | 1 |
| Siahanidou, T | 1 |
| Banerjee, I | 1 |
| Akcay, T | 2 |
| Rubio-Cabezas, O | 1 |
| Shield, JP | 2 |
| Gray, SL | 1 |
| Donald, C | 1 |
| Jetha, A | 1 |
| Covey, SD | 1 |
| Kieffer, TJ | 1 |
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| Grimaldi, GP | 1 |
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| Blethen, SL | 1 |
| Santiago, JV | 1 |
| Daughaday, WH | 1 |
| Oliete García, F | 1 |
| Herrera Andújar, P | 1 |
| Pérez Carmona, NJ | 1 |
| Balboa de Paz, F | 1 |
| Maertens, P | 1 |
| de Geeter, B | 1 |
| Kurtz, F | 1 |
| Messer, J | 1 |
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| Landau, H | 2 |
| Baker, L | 4 |
| Pronicka, E | 1 |
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| Woźniewicz, B | 1 |
| Cedro, A | 1 |
| Kamiński, W | 1 |
| Leśniewska, A | 1 |
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| Skrha, J | 3 |
| Svacina, S | 2 |
| Justová, V | 2 |
| Wichterle, D | 1 |
| Hilgertová, J | 1 |
| Féliz-De Vargas Pastor, J | 1 |
| García Jiménez, I | 1 |
| Sánchez Miramón, F | 1 |
| García López, P | 1 |
| Uriel Miñana, P | 1 |
| Baldellou Vázquez, A | 1 |
| Rebaje Moise, V | 1 |
| Carter, BS | 1 |
| Aparicio, L | 1 |
| Carpenter, MW | 1 |
| Schwartz, R | 1 |
| Gruppuso, PA | 1 |
| Daneman, D | 2 |
| Ehrlich, RM | 1 |
| Alter, CA | 1 |
| Katz, LE | 1 |
| Hirsch, HJ | 1 |
| Boyle, PJ | 1 |
| Justice, K | 1 |
| Krentz, AJ | 1 |
| Nagy, RJ | 1 |
| Schade, DS | 1 |
| Nichols, CG | 2 |
| Shyng, SL | 3 |
| Nestorowicz, A | 2 |
| Clement, JP | 1 |
| Gonzalez, G | 1 |
| Permutt, MA | 2 |
| Elased, KM | 1 |
| Playfair, JH | 1 |
| Bercovici, JP | 1 |
| Monguillon, P | 1 |
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| Johnson, PR | 1 |
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| van Montfrans, JM | 1 |
| van Hooff, MH | 1 |
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| Alemzadeh, R | 2 |
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| Shepard, JB | 1 |
| Touati, G | 5 |
| Poggi-Travert, F | 1 |
| Ogier de Baulny, H | 1 |
| Brunelle, F | 4 |
| Nihoul-Fekete, C | 5 |
| Czernichow, P | 1 |
| Saudubray, JM | 6 |
| Panesar, NS | 1 |
| Poon, CW | 1 |
| Liew, CT | 1 |
| Wong, GW | 1 |
| Hjelm, NM | 1 |
| de Lonlay-Debeney, P | 1 |
| Fournet, JC | 3 |
| Martin, D | 2 |
| Poggi, F | 1 |
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| Shaer, AJ | 1 |
| Groos, MS | 1 |
| Delagne, V | 1 |
| Mayaud, C | 1 |
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| Brusset, MC | 1 |
| Laborde, K | 1 |
| Bellane-Chantelot, C | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diazoxide-mediated Insulin Suppression in Hyperinsulinemic Obese Men, Part III[NCT00631033] | Phase 2 | 51 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| Clinical Assessment of the Treatment With Diazoxide in Children Suffering From Obesity and Hyperinsulinemia Secondary to Surgery of Hypothalamic-pituitary Lesions[NCT00306683] | Phase 3 | 40 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| Is There An Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?[NCT02803476] | 166 participants (Anticipated) | Observational | 2016-03-31 | Recruiting | |||
| Use for Diazoxide in the Initial Management of Hypoglycemia in Infants of Diabetic Mothers and Infants Large for Gestation[NCT00994149] | Phase 2/Phase 3 | 100 participants (Anticipated) | Interventional | 2009-10-31 | Not yet recruiting | ||
| A Prospective Randomized, Placebo (Saline)-Controlled, Balanced, 3-treatment Regimen Crossover Study Comparing the Effects of Prolonged (13 h) Hyperglucagonemia With Those of Acute (3 hr) Hyperglucagonemia on Energy Expenditure and Endogenous Glucose Prot[NCT02237053] | Phase 1 | 6 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| [NCT01626443] | Phase 4 | 46 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| The Effect of Acupuncture on Insulin Sensitivity of Women With Polycystic Ovary Syndrome and Insulin Resistance: a Randomized Controlled Trial[NCT02491333] | Phase 3 | 342 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| Efficacy of Vitamin E in Hyperinsulinism/Hyperammonemia Syndrome[NCT04984798] | Phase 2 | 0 participants (Actual) | Interventional | 2022-11-30 | Withdrawn (stopped due to No study activity took place. The IND was withdrawn with the FDA by the Sponsor Investigator because of insurmountable hurdles in moving proposed research forward) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
26 reviews available for diazoxide and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Drug-induced hyperinsulinemic hypoglycemia: An update on pathophysiology and treatment.
Topics: Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Insulin Secretion | 2023 |
Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis.
Topics: Antihypertensive Agents; Diazoxide; Humans; Hyperinsulinism; Hypertrichosis; Hypoglycemia; Treatment | 2021 |
Expanding the spectrum of endocrinopathies identified in Schaaf-Yang syndrome - A case report and review of the literature.
Topics: Developmental Disabilities; Diazoxide; Female; Humans; Hyperinsulinism; Infant; Insulin; Mutation; P | 2021 |
Autoimmune hypoglycemia due to anti-insulin antibodies.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Autoimmune Dis | 2018 |
Hyperinsulinism in the Neonate.
Topics: Abnormalities, Multiple; Antihypertensive Agents; Beckwith-Wiedemann Syndrome; Congenital Hyperinsul | 2018 |
Update on neonatal hypoglycemia.
Topics: Biosensing Techniques; Blood Glucose; Developmental Disabilities; Diazoxide; Diuretics; Female; Gluc | 2014 |
When it is more than transient neonatal hypoglycemia: hyperinsulinemia--a case study challenge.
Topics: Blood Glucose; Brain Damage, Chronic; Diagnosis, Differential; Diazoxide; Enteral Nutrition; Female; | 2001 |
[PHHI (persistent hyperinsulinemic hypoglycemia of infancy)].
Topics: Animals; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Diagnosis, Differential; Diazo | 2002 |
[Islet cell cancer with organic hyperinsulinism. Clinical aspects, diagnosis and therapy].
Topics: Adenoma; Adenoma, Islet Cell; C-Peptide; Diagnosis, Differential; Diazoxide; Female; Glucagon; Human | 1982 |
Hyperinsulinism in infancy and childhood.
Topics: Beckwith-Wiedemann Syndrome; Blood Glucose; Child, Preschool; Diazoxide; Erythroblastosis, Fetal; Fe | 1984 |
Hypoglycaemia in infancy and childhood.
Topics: Blood Glucose; Child; Child, Preschool; Diazoxide; Fasting; Glycogen Storage Disease Type I; Humans; | 1984 |
Hyperinsulinism in infants and children.
Topics: Child; Combined Modality Therapy; Diazoxide; Humans; Hyperinsulinism; Infant; Octreotide; Pancreatec | 1997 |
Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications.
Topics: Adrenal Glands; Androgens; Anovulation; Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypogl | 1997 |
Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications.
Topics: Adrenal Glands; Androgens; Anovulation; Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypogl | 1997 |
Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications.
Topics: Adrenal Glands; Androgens; Anovulation; Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypogl | 1997 |
Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications.
Topics: Adrenal Glands; Androgens; Anovulation; Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypogl | 1997 |
[Persistent hyperinsulinemic hypoglycemia of infancy (PHHI)].
Topics: Adenosine Triphosphate; Diazoxide; Glycosyltransferases; GTP-Binding Proteins; Humans; Hyperinsulini | 1997 |
Treatment of hyperinsulinaemia in polycystic ovary syndrome?
Topics: Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Metformin; Polycystic Ova | 1998 |
Persistent hyperinsulinemic hypoglycemia of infancy: long-term results.
Topics: Adolescent; Adult; Child; Child, Preschool; Diazoxide; Dietary Proteins; Female; Hormones; Humans; H | 1998 |
[Persistent hyperinsulinemic hypoglycemia in the newborn and infants].
Topics: Diazoxide; Diuretics; Genetic Counseling; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, New | 1998 |
Insulin-lowering medications in polycystic ovary syndrome.
Topics: Diazoxide; Female; Humans; Hyperandrogenism; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistanc | 2000 |
Management of hyperinsulinism in infancy and childhood.
Topics: Blood Glucose; Calcium Channel Blockers; Child; Child, Preschool; Chlorothiazide; Diazoxide; Glucago | 2000 |
Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases.
Topics: Age of Onset; Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Genetic Heterogeneity; Gluc | 2002 |
Persistent hyperinsulinaemic hypoglycaemia.
Topics: Diazoxide; Diuretics; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Pancreatectomy; Progno | 2002 |
[Juvenile endocrine hypoglycemia].
Topics: Adenoma; Child, Preschool; Diazoxide; Folic Acid; Fructose-1,6-Diphosphatase Deficiency; Gluconeogen | 1979 |
Hyperinsulinism in infants and children: diagnosis and therapy.
Topics: Adult; Blood Glucose; Child; Child, Preschool; Diazoxide; Fatty Acids, Nonesterified; Humans; Hydrox | 1976 |
Medical management of canine hyperinsulinism.
Topics: Adrenal Cortex Hormones; Animals; Blood Glucose; Combined Modality Therapy; Diazoxide; Diet Therapy; | 1985 |
Hypoglycemia in infancy and childhood. II.
Topics: Adrenal Cortex Hormones; Adrenal Gland Diseases; Amino Acids; Carbohydrate Metabolism, Inborn Errors | 1973 |
[The hypoglycemia syndrome].
Topics: Alloxan; Angiography; Antibiotics, Antineoplastic; Blood Glucose; Diagnosis, Differential; Diazoxide | 1970 |
8 trials available for diazoxide and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome.
Topics: Adolescent; Basal Metabolism; Body Composition; Child; Delayed-Action Preparations; Diazoxide; Doubl | 2019 |
High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention.
Topics: Adult; Blood Glucose; Body Mass Index; Body Weight; Diazoxide; Dose-Response Relationship, Drug; Dou | 2018 |
Rate of Serious Adverse Events Associated with Diazoxide Treatment of Patients with Hyperinsulinism.
Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hypertension, Pulmonary; Infant; Infant, Newborn; Male; | 2019 |
Diazoxide in Children With Obesity After Hypothalamic-Pituitary Lesions: A Randomized, Placebo-Controlled Trial.
Topics: Adolescent; Child; Diabetes Mellitus; Diazoxide; Double-Blind Method; Humans; Hyperinsulinism; Hypog | 2016 |
A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome.
Topics: Administration, Oral; Adult; Androgens; Blood Glucose; Body Weight; Comorbidity; Diazoxide; Dose-Res | 2012 |
No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet.
Topics: Adult; Blood Glucose; C-Peptide; Counseling; Diazoxide; Diet, Reducing; Double-Blind Method; Energy | 2007 |
Treatment of hyperinsulinaemia in polycystic ovary syndrome?
Topics: Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Metformin; Polycystic Ova | 1998 |
Beneficial effect of diazoxide in obese hyperinsulinemic adults.
Topics: Adult; Body Composition; Body Mass Index; Body Weight; Diazoxide; Diet, Reducing; Energy Intake; Fem | 1998 |
173 other studies available for diazoxide and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Clinical and genetic heterogeneity of HNF4A/HNF1A mutations in a multicentre paediatric cohort with hyperinsulinaemic hypoglycaemia.
Topics: Adolescent; Birth Weight; Child; Child, Preschool; Cohort Studies; Diabetes Mellitus, Type 1; Diabet | 2022 |
Hyperinsulinism May Be Underreported in Hypoglycemic Patients with Phosphomannomutase 2 Deficiency
Topics: Congenital Disorders of Glycosylation; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Hypoglycemi | 2022 |
Management of pregnancy in a patient with congenital hyperinsulinism treated with association of diazoxide/calcium channel blocker.
Topics: Calcium Channel Blockers; Congenital Hyperinsulinism; Diazoxide; Female; Humans; Hyperinsulinism; In | 2022 |
Diagnosis and Treatment Course of Insulinoma Presenting as Hypoglycemia Unawareness Using a Factory-Calibrated Continuous Glucose Monitoring System.
Topics: Adult; Blood Glucose; Blood Glucose Self-Monitoring; Diabetes Complications; Diazoxide; Humans; Hype | 2022 |
Hyperinsulinism-hyperammonemia syndrome in two Peruvian children with refractory epilepsy.
Topics: Child; Congenital Hyperinsulinism; Diazoxide; Drug Resistant Epilepsy; Epilepsy; Glutamate Dehydroge | 2023 |
Hyperinsulinism-hyperammonemia syndrome in two Peruvian children with refractory epilepsy.
Topics: Child; Congenital Hyperinsulinism; Diazoxide; Drug Resistant Epilepsy; Epilepsy; Glutamate Dehydroge | 2023 |
Hyperinsulinism-hyperammonemia syndrome in two Peruvian children with refractory epilepsy.
Topics: Child; Congenital Hyperinsulinism; Diazoxide; Drug Resistant Epilepsy; Epilepsy; Glutamate Dehydroge | 2023 |
Hyperinsulinism-hyperammonemia syndrome in two Peruvian children with refractory epilepsy.
Topics: Child; Congenital Hyperinsulinism; Diazoxide; Drug Resistant Epilepsy; Epilepsy; Glutamate Dehydroge | 2023 |
Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism.
Topics: Animals; Antibodies; Blood Glucose; Congenital Hyperinsulinism; Diazoxide; Glucagon-Like Peptide 1; | 2023 |
Watchful waiting versus pharmacological management of small-for-gestational-age infants with hyperinsulinemic hypoglycemia.
Topics: Awareness; Cognition; Diazoxide; Fasting; Humans; Hyperinsulinism; Hypoglycemia; Infant; Watchful Wa | 2023 |
Characterization of the duration of treatment with diazoxide in infants with prolonged hyperinsulinism (PHI).
Topics: Adolescent; Adult; Antihypertensive Agents; Biomarkers; Blood Glucose; Child; Child, Preschool; Diaz | 2019 |
Hyperinsulinaemic hypoglycaemia in deoxyguanosine kinase deficiency.
Topics: Adult; Congenital Hyperinsulinism; Diazoxide; Drug Administration Schedule; Humans; Hyperinsulinism; | 2019 |
Thrombocytopaenia: a serious side effect of diazoxide.
Topics: Antihypertensive Agents; Child, Preschool; Diazoxide; Drug Therapy, Combination; Epistaxis; Hemateme | 2019 |
Higher C-peptide levels and glucose requirements may identify neonates with transient hyperinsulinism hypoglycemia who will benefit from diazoxide treatment.
Topics: Adult; Blood Glucose; C-Peptide; Case-Control Studies; Diazoxide; Female; Gestational Age; Humans; H | 2020 |
Hyperinsulinism hyperammonaemia (HI/HA) syndrome due to GLUD1 mutation: phenotypic variations ranging from late presentation to spontaneous resolution.
Topics: Ammonia; Blood Glucose; Child; Child, Preschool; Diazoxide; Female; Glutamate Dehydrogenase; Humans; | 2020 |
Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome.
Topics: Adult; Diazoxide; Diet, Carbohydrate Loading; Directive Counseling; Female; Humans; Hyperammonemia; | 2020 |
Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism.
Topics: Child; Child, Preschool; Diazoxide; Disease Management; Female; Humans; Hyperinsulinism; Hypoglycemi | 2020 |
[Transient hyperinsulinism in neonates].
Topics: Diazoxide; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Insulin | 2020 |
50 Years Ago in TheJournalofPediatrics: Diazoxide-Induced Hyperosmolar Nonketotic Coma: Contemporary Genetic Insights.
Topics: Child; Diazoxide; Humans; Hyperglycemic Hyperosmolar Nonketotic Coma; Hyperinsulinism | 2021 |
Challenges in management of transient hyperinsulinism - a retrospective analysis of 36 severely affected children.
Topics: Diazoxide; Female; Genetic Testing; Humans; Hyperinsulinism; Infant; Infant, Newborn; Male; Octreoti | 2021 |
Neonatal hyperinsulinism in transient and classical forms of tyrosinemia.
Topics: Congenital Hyperinsulinism; Diazoxide; Humans; Hyperinsulinism; Infant; Infant, Newborn; Liver; Tyro | 2021 |
Suppression of hyperinsulinemia restores growth hormone secretion and metabolism in obese mice.
Topics: Animals; Body Composition; Diazoxide; Diet, High-Fat; Energy Metabolism; Growth Hormone; Hyperinsuli | 2021 |
Sirolimus in infants with congenital hyperinsulinism (CHI) - a single-centre experience.
Topics: Congenital Hyperinsulinism; Diazoxide; Glucose; Humans; Hyperinsulinism; Infant; Infant, Newborn; Mu | 2022 |
Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations.
Topics: Child; Diazoxide; Female; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 4; Humans; Hy | 2018 |
Congenital Hyperinsulinemic Hypoglycemia and Hyperammonemia due to Pathogenic Variants in GLUD1.
Topics: Congenital Hyperinsulinism; Diazoxide; Female; Genetic Predisposition to Disease; Glutamate Dehydrog | 2019 |
[Hirata's disease: report of a case].
Topics: Aged, 80 and over; Asian People; Autoimmune Diseases; Diazoxide; Drug Substitution; Edema; HLA-D Ant | 2014 |
Hyperinsulinemic hypoglycemia: experience in a series of 17 cases.
Topics: Child; Child, Preschool; Developmental Disabilities; Diazoxide; Epilepsy; Female; Humans; Hyperinsul | 2013 |
Delayed presentation of prolonged hyperinsulinaemic hypoglycaemia in a preterm small-for-gestational age neonate.
Topics: Blood Glucose; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Infant, Sm | 2013 |
Hyperinsulinism in a neonate.
Topics: Blood Glucose; Diagnosis, Differential; Diazoxide; Humans; Hyperinsulinism; Infant, Newborn; Infant, | 2014 |
Refractory hypoglycaemia in patient with gastric outlet obstruction.
Topics: Aged; Angiography; Diazoxide; Endosonography; Gastric Bypass; Gastric Outlet Obstruction; Glucose; H | 2015 |
Liver injury may increase the risk of diazoxide toxicity: a case report.
Topics: Albumins; Blood Glucose; Chemical and Drug Induced Liver Injury; Diazoxide; Heart Failure; Humans; H | 2015 |
Fetal Erythroblastosis May Be an Indicator of Neonatal Transient Hyperinsulinism.
Topics: Apgar Score; Birth Weight; Diazoxide; Erythroblastosis, Fetal; Erythrocyte Count; Female; Gestationa | 2015 |
Prolonged hyperglycemia & hyperinsulinemia increases BDNF mRNA expression in the posterior ventromedial hypothalamus and the dorsomedial hypothalamus of fed female rats.
Topics: Animals; Blood Glucose; Brain-Derived Neurotrophic Factor; Diazoxide; Dorsomedial Hypothalamic Nucle | 2015 |
Genotype and phenotype correlations in Iranian patients with hyperinsulinaemic hypoglycaemia.
Topics: Cohort Studies; Cross-Sectional Studies; Diazoxide; DNA Mutational Analysis; Female; Gene Expression | 2015 |
Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Diazoxide; Drug Monitoring; Drug Resistance; Edema | 2016 |
A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma.
Topics: Biopsy; Blood Glucose; C-Peptide; Carcinoma, Neuroendocrine; Diazoxide; Humans; Hyperinsulinism; Hyp | 2016 |
Heterogeneity in phenotype of hyperinsulinism caused by activating glucokinase mutations: a novel mutation and its functional characterization.
Topics: Adolescent; Adult; Child; Child, Preschool; Diazoxide; Enzyme Activation; Female; Glucokinase; Human | 2017 |
Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations.
Topics: Adolescent; Amino Acid Substitution; Birth Weight; Blood Glucose; Child; Circadian Rhythm; Diazoxide | 2009 |
Successful medical management of status post-Roux-en-Y-gastric-bypass hyperinsulinemic hypoglycemia.
Topics: Antihypertensive Agents; Diazoxide; Female; Gastric Bypass; Humans; Hyperinsulinism; Hypoglycemia; M | 2009 |
Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations.
Topics: Adolescent; Child; Child, Preschool; Cohort Studies; Congenital Hyperinsulinism; Diazoxide; Female; | 2010 |
Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling.
Topics: Adiposity; Animals; Blood Glucose; Body Weight; Diazoxide; Eating; Female; Hyperinsulinism; Hypoglyc | 2010 |
Anemia and neutropenic fever with high dose diazoxide treatment in a case with hyperinsulinism due to Munchausen by proxy.
Topics: Anemia; Bone Marrow; Child; Diazoxide; Female; Fever; Humans; Hyperinsulinism; Munchausen Syndrome b | 2010 |
Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Cohort Studies; Consanguinity; Diazoxide; Diuretics; Female; Genom | 2011 |
Characterization of ABCC8 and KCNJ11 gene mutations and phenotypes in Korean patients with congenital hyperinsulinism.
Topics: Age of Onset; Asian People; ATP-Binding Cassette Transporters; Diazoxide; Diuretics; DNA; DNA Mutati | 2011 |
Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide.
Topics: Diagnosis, Differential; Diazoxide; Ductus Arteriosus, Patent; Humans; Hyperinsulinism; Hypertension | 2011 |
Neonatal hyperinsulinism secondary to maternal intake of high-sugar drinks.
Topics: Antihypertensive Agents; Carbonated Beverages; Diazoxide; Female; Glucose; Humans; Hyperinsulinism; | 2011 |
Congenital hyperinsulinism caused by hexokinase I expression or glucokinase-activating mutation in a subset of β-cells.
Topics: Amino Acid Substitution; Diazoxide; Glucokinase; Hexokinase; Humans; Hyperinsulinism; Hypoglycemic A | 2013 |
Clinical and molecular characterisation of hyperinsulinaemic hypoglycaemia in infants born small-for-gestational age.
Topics: Antihypertensive Agents; ATP-Binding Cassette Transporters; Blood Glucose; Diazoxide; Gestational Ag | 2013 |
Neonatal hyperinsulinemic hypoglycemia. Two case reports.
Topics: Asphyxia Neonatorum; Blood Glucose; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newbor | 2002 |
Pancreatectomy extension in persistent hyperinsulinaemic hypoglycaemia: a new strategy.
Topics: Adenoma, Islet Cell; Algorithms; Child; Child, Preschool; Diazoxide; Humans; Hyperinsulinism; Hypogl | 2002 |
Persistent hyperinsulinemic hypoglycemia of infancy: experience at Siriraj Hospital.
Topics: Blood Glucose; Diazoxide; Drug Therapy, Combination; Female; Glucagon; Glucose; Hospitals, Universit | 2002 |
Uncontrolled insulin secretion from a childhood pancreatic beta-cell adenoma is not due to the functional loss of ATP-sensitive potassium channels.
Topics: Adenoma, Islet Cell; Adenosine Triphosphate; Antihypertensive Agents; Child; Chromosomes, Human, Pai | 2002 |
Persistent hyperinsulinaemic hypoglycaemia of infancy: case report.
Topics: Anti-Inflammatory Agents; Blood Glucose; Consanguinity; Diazoxide; Epilepsy; Glucagon; Humans; Hyper | 2002 |
Persistent hyperinsulinemic hypoglycaemia followed as benign infantile convulsion.
Topics: Diazoxide; Electroencephalography; Epilepsy, Benign Neonatal; Glucose; Humans; Hyperinsulinism; Hypo | 2003 |
Long-term follow-up of 114 patients with congenital hyperinsulinism.
Topics: Adolescent; Age of Onset; Child; Child, Preschool; Developmental Disabilities; Diabetes Mellitus, Ty | 2003 |
Interactions of diazoxide with frusemide, spironolactone, and acetylsalicylic acid in a patient with hyperinsulinism of Infancy and Fallot tetralogy.
Topics: Aspirin; Diazoxide; Drug Interactions; Drug Therapy, Combination; Female; Follow-Up Studies; Furosem | 2003 |
HYPERINSULINISM DUE TO METASTASIZING INSULINOMA: TREATMENT WITH DIAZOXIDE.
Topics: Adenoma, Islet Cell; Diazoxide; Drug Therapy; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulino | 1965 |
Hyperinsulinaemic hypoglycaemia in preterm neonates.
Topics: Birth Weight; Chlorothiazide; Diazoxide; Diuretics; Female; Glucose; Humans; Hyperinsulinism; Hypogl | 2004 |
Trimethoprim-sulfamethoxazole induced prolonged hypoglycemia in an infant with MHC class II deficiency: diazoxide as a treatment option.
Topics: Blood Glucose; C-Peptide; Diazoxide; Drug Administration Schedule; Female; Gene Expression; Genes, M | 2003 |
Severe transient neonatal hyperinsulinism associated with hyperlactataemia in non-asphyxiated infants.
Topics: Acidosis; Age of Onset; Blood Glucose; C-Peptide; Chlorothiazide; Diazoxide; Diuretics; Fasting; Fat | 2004 |
A case of severe diazoxide toxicity.
Topics: Blood Glucose; Diazoxide; Edema; Heart Failure; Humans; Hyperinsulinism; Infant; Male; Pancreatectom | 2004 |
[Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide].
Topics: Diazoxide; Glutamate Dehydrogenase; Humans; Hyperammonemia; Hyperinsulinism; Infant; Male; Mutation; | 2004 |
Genotype-phenotype correlations in children with congenital hyperinsulinism due to recessive mutations of the adenosine triphosphate-sensitive potassium channel genes.
Topics: Amino Acid Substitution; ATP-Binding Cassette Transporters; Base Sequence; Child; Diazoxide; Genes, | 2005 |
Hyperinsulinism of infancy associated with a novel splice site mutation in the SCHAD gene.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Chlorothiazide; Diazoxide; Diuretics; Humans; Hyperinsulinism; Inf | 2005 |
Hyperinsulinism in tyrosinaemia type I.
Topics: Blood Glucose; C-Peptide; Chlorothiazide; Diazoxide; Diuretics; Humans; Hyperinsulinism; Hypoglycemi | 2005 |
Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinism.
Topics: Adenosine Triphosphate; ATP-Binding Cassette Transporters; Child, Preschool; Diazoxide; Epinephrine; | 2005 |
Costello syndrome and hyperinsulinemic hypoglycemia.
Topics: Abnormalities, Multiple; Diazoxide; Fatal Outcome; Female; Humans; Hyperinsulinism; Hypoglycemia; In | 2005 |
Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism.
Topics: Antihypertensive Agents; Calcium; Case-Control Studies; Diazoxide; Enteral Nutrition; Fasting; Femal | 2006 |
A rare case of adult-onset nesidioblastosis treated successfully with diazoxide.
Topics: Angiography; Blood Glucose; Diagnosis, Differential; Diazoxide; Humans; Hyperinsulinism; Hypoglycemi | 2006 |
Clinical features and morphological characterization of 10 patients with noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS).
Topics: Adult; Aged; Amyloid; Antigens, Neoplasm; Biomarkers; Biomarkers, Tumor; C-Peptide; Cell Proliferati | 2006 |
Prolonged hyperinsulinaemic hypoglycaemia in newborns with intrauterine growth retardation.
Topics: Chlorothiazide; Diazoxide; Fetal Growth Retardation; Humans; Hyperinsulinism; Hypoglycemia; Hypoglyc | 2006 |
Mosaic Turner syndrome and hyperinsulinaemic hypoglycaemia.
Topics: Chromosome Aberrations; Chromosomes, Human, X; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglyce | 2006 |
Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats.
Topics: Animals; ATP-Binding Cassette Transporters; Blood Glucose; Brain; Diazoxide; Drug Combinations; Estr | 2007 |
Development of pulmonary hypertension in an infant treated with diazoxide.
Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hypertension, Pulmonary; Hypoglycemia; Hypoglycemic Agen | 2007 |
Correlates between hyperinsulinism and hyperandrogenemia?
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Adenosine Triphosphate; Aldo-Keto | 2008 |
Nesidioblastosis in children.
Topics: Adenoma, Islet Cell; Child, Preschool; Diazoxide; Female; Glucagon; Glucose; Humans; Hyperinsulinism | 1980 |
[Hypokalemia caused by hyperinsulinemia in infancy and childhood (based on 18 cases)].
Topics: Blood Glucose; Child; Child, Preschool; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant; In | 1984 |
Hyperinsulinaemic hypoglycaemia in infancy and childhood: a practical approach to diagnosis and medical treatment based on experience of 18 cases.
Topics: Blood Glucose; Child; Diazoxide; Female; Glucose; Glucose Tolerance Test; Glycerol; Humans; Hyperins | 1984 |
[Hyperinsulinemia--a case report].
Topics: Diazoxide; Humans; Hyperinsulinism; Infant, Newborn; Infant, Newborn, Diseases; Male | 1983 |
Persistent leucine sensitivity following partial pancreatectomy and diazoxide treatment. Therapeutic response.
Topics: Child, Preschool; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Leucine; Pancreatectomy; | 1983 |
Hyperinsulinism.
Topics: Amino Acids, Branched-Chain; B-Lymphocytes; Blood Glucose; Child, Preschool; Diazoxide; Humans; Hype | 1980 |
Nesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia.
Topics: Diazoxide; Female; Glucose; Humans; Hyperinsulinism; Hypoglycemia; In Vitro Techniques; Infant, Newb | 1981 |
[Evaluation of the metabolic action of glucagon in subjects undergoing anti-insulin therapy].
Topics: Adult; Blood Glucose; Diazoxide; Glucagon; Growth Hormone; Humans; Hyperinsulinism; Insulin; Lipids; | 1981 |
[Long-term diazoxide therapy of the Beckwith-Wiedemann syndrome with persistent hypoglycemia].
Topics: Beckwith-Wiedemann Syndrome; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant | 1982 |
Plasma somatomedins in children with hyperinsulinism.
Topics: Child, Preschool; Diazoxide; Female; Humans; Hyperinsulinism; Infant; Infant, Newborn; Male; Pancrea | 1981 |
[Hyperinsulinism probably caused by diffuse pancreatic hyperplasia].
Topics: Child, Preschool; Diazoxide; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; Male; Pancreas; Psy | 1980 |
[Long-term diazoxide therapy in recurrent leucine-sensitive hypoglycemia (author's transl)].
Topics: Child, Preschool; Diazoxide; Female; Growth; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, | 1980 |
Neonatal hyperinsulinism--surgical and pathologic considerations.
Topics: Diazoxide; Female; Humans; Hyperinsulinism; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male | 1980 |
Neonatal hypoglycemia.
Topics: Diazoxide; England; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn | 1994 |
Pancreatic glucagon levels in infants and children with hyperinsulinemia.
Topics: Adolescent; Adult; Child; Child, Preschool; Diazoxide; Female; Glucagon; Humans; Hyperinsulinism; Hy | 1995 |
[The effect of Proglicem in patients with an organic hyperinsulinism syndrome].
Topics: Adult; Aged; Diazoxide; Female; Humans; Hyperinsulinism; Insulinoma; Male; Middle Aged; Pancreatic N | 1994 |
Insulin action in patients with insulinoma influenced by pharmacological and surgical therapy.
Topics: Adult; Aged; Blood Glucose; Diazoxide; Female; Humans; Hyperinsulinism; Insulin; Insulin Resistance; | 1993 |
[Hyperinsulinemic hypoglycemia: a study of four cases].
Topics: Algorithms; Diazoxide; Female; Glucagon; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Insulin; Li | 1993 |
Increased nucleated erythrocytes in an infant with congenital hyperinsulinism.
Topics: Diazoxide; Erythrocyte Count; Humans; Hyperinsulinism; Infant, Newborn; Male | 1994 |
Prenatal diagnosis of familial neonatal hyperinsulinemia.
Topics: Administration, Oral; Amniotic Fluid; Blood Glucose; Diazoxide; Female; Fetal Blood; Glucose; Humans | 1993 |
The enigma of persistent hyperinsulinemic hypoglycemia of infancy.
Topics: Diazoxide; Glucagon; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, Newborn; Octreo | 1993 |
Short- and long-term use of octreotide in the treatment of congenital hyperinsulinism.
Topics: Diazoxide; Female; Follow-Up Studies; Glucagon; Glucose; Growth Disorders; Humans; Hyperinsulinism; | 1993 |
Persistent hyperinsulinemic hypoglycemia of infancy: long-term octreotide treatment without pancreatectomy.
Topics: Diazoxide; Female; Follow-Up Studies; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Male; | 1993 |
Octreotide reverses hyperinsulinemia and prevents hypoglycemia induced by sulfonylurea overdoses.
Topics: Adult; Blood Glucose; Diazoxide; Drug Overdose; Female; Glucose; Humans; Hyperinsulinism; Hypoglycem | 1993 |
Adenosine diphosphate as an intracellular regulator of insulin secretion.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Tr | 1996 |
Reversal of hypoglycaemia in murine malaria by drugs that inhibit insulin secretion.
Topics: Animals; Antimalarials; Blood Glucose; Diazoxide; Epinephrine; Hyperinsulinism; Hypoglycemia; Insuli | 1996 |
[Polycystic ovary and diazoxide. In vivo study].
Topics: Adolescent; Androgens; Dehydroepiandrosterone; Diazoxide; Female; Hirsutism; Humans; Hyperinsulinism | 1996 |
Therapy for persistent hyperinsulinemic hypoglycemia of infancy. Understanding the responsiveness of beta cells to diazoxide and somatostatin.
Topics: Blood Glucose; Cell Membrane; Diazoxide; Disease Management; Electrophysiology; Glycosyltransferases | 1997 |
Preoperative use of octreotide in a newborn with persistent hyperinsulinemic hypoglycemia of infancy.
Topics: Diazoxide; Female; Glucose; Hormones; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Octreo | 1998 |
Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alleles; Animals; ATP-Binding Cassette Transporters; | 1998 |
Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: a retrospective review of 77 cases and analysis of efficacy-predicting criteria.
Topics: Diazoxide; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hyperinsu | 1998 |
Histochemical, clinical, and in vitro beta cell responses in a neonate with persistent hyperinsulinaemic hypoglycaemia of infancy.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Diazoxide; Diuretics; Glucose; Humans; Hyperinsulinism | 1998 |
Loss of imprinted genes and paternal SUR1 mutations lead to hyperinsulinism in focal adenomatous hyperplasia.
Topics: Adenoma, Islet Cell; ATP-Binding Cassette Transporters; Chromosomes, Human, Pair 11; Diazoxide; Drug | 1998 |
Long-term follow up of persistent hyperinsulinaemic hypoglycaemia of infancy.
Topics: Diazoxide; Electroencephalography; Female; Follow-Up Studies; Head; Humans; Hyperinsulinism; Hypogly | 1998 |
Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; ATP-Binding Cassette Transporters; | 2000 |
Neurologic outcomes of 90 neonates and infants with persistent hyperinsulinemic hypoglycemia.
Topics: Age of Onset; Child; Child, Preschool; Developmental Disabilities; Diazoxide; Epilepsy; Humans; Hype | 2001 |
Transient hyperinsulinism in an asphyxiated newborn infant with hypoglycemia.
Topics: Asphyxia Neonatorum; Blood Glucose; Diazoxide; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Infan | 2001 |
Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome.
Topics: Adolescent; Adult; Amino Acid Substitution; Ammonia; Blood Glucose; Child; Child, Preschool; Diazoxi | 2001 |
Management of hyperinsulinemia with diazoxide in an elderly hemodialysis patient.
Topics: Aged; Aged, 80 and over; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Insulinoma; Nutrition Dis | 2001 |
Identification of a familial hyperinsulinism-causing mutation in the sulfonylurea receptor 1 that prevents normal trafficking and function of KATP channels.
Topics: Amino Acid Motifs; Animals; Antihypertensive Agents; ATP-Binding Cassette Transporters; Base Sequenc | 2002 |
Ten years' experience of persistent hyperinsulinaemic hypoglycaemia of infancy.
Topics: Adolescent; Blood Glucose; Chi-Square Distribution; Child; Child Development; Child, Preschool; Diaz | 2001 |
Compound heterozygosity for the common sulfonylurea receptor mutations can cause mild diazoxide-sensitive hyperinsulinism.
Topics: ATP-Binding Cassette Transporters; Diazoxide; Electrophoresis, Gel, Two-Dimensional; Genetic Predisp | 2002 |
Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats.
Topics: Animals; Blood Glucose; Body Weight; Diazoxide; Eating; Female; Glucokinase; Gluconeogenesis; Glucos | 2002 |
Hypoglycemia: a perspective.
Topics: Adenoma, Islet Cell; Citric Acid Cycle; Diabetes Complications; Diazoxide; Female; Glucose; Glucose | 1975 |
Medical treatment of endogenous organic hyperinsulinism.
Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Child; Chlorpromazine; Diazoxide; Female; Humans; Hyperin | 1976 |
Pancreatic adenomas in infants and children: current surgical management.
Topics: Adenoma, Islet Cell; Child; Child, Preschool; Diazoxide; Follow-Up Studies; Humans; Hyperinsulinism; | 1978 |
Lipodystrophy with hyperlipidaemia: the role of insulin in very low density lipoprotein over-synthesis.
Topics: Adult; Diazoxide; Female; Humans; Hyperinsulinism; Hyperlipidemias; Insulin; Lipodystrophy; Lipoprot | 1979 |
Down regulation of insulin receptors.
Topics: Animals; Concanavalin A; Culture Techniques; Cyclic AMP; Diazoxide; Homeostasis; Humans; Hyperinsuli | 1979 |
Treatment of hyperinsulinism after partial pancreatectomy: medical or surgical?
Topics: Adult; Diazoxide; Humans; Hyperglycemia; Hyperinsulinism; Male; Pancreatectomy | 1978 |
[Treatment of organic hyperinsulinism with diazoxide].
Topics: Diazoxide; Female; Humans; Hyperinsulinism; Middle Aged; Pancreatic Neoplasms; Postoperative Complic | 1979 |
Neonatal pancreatic beta-cell hyperplasia: report of a case with failure of diazoxide and benefit of early subtotal pancreatectomy.
Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; Infant, Newborn; Infant, Newb | 1976 |
[Potentiation of the effects of diazoxide by chlorpromazine in the treatment of organic hyperinsulinism].
Topics: Chlorpromazine; Diazoxide; Drug Synergism; Female; Humans; Hyperinsulinism; Middle Aged | 1977 |
Hyperosmolar non-ketotic hyperglycaemia during oral diazoxide therapy of prolonged hyperglycaemia in infancy.
Topics: Age Factors; Diabetic Coma; Diazoxide; Humans; Hyperglycemic Hyperosmolar Nonketotic Coma; Hyperinsu | 1977 |
[Leucine-sensitive hypoglycaemia and its treatment with diazoxide (author's transl)].
Topics: Amino Acid Metabolism, Inborn Errors; Blood Glucose; Diazoxide; Dietary Proteins; Female; Humans; Hy | 1976 |
[Diagnosis of organic hyperinsulinism].
Topics: Diagnosis, Differential; Diazoxide; Fasting; Glucagon; Glucose Tolerance Test; Humans; Hyperinsulini | 1975 |
Drug interaction: diazoxide and diphenylhydantoin.
Topics: Administration, Oral; Adolescent; Child, Preschool; Chromatography, Gas; Diazoxide; Drug Therapy, Co | 1975 |
Palliative treatment of hyperinsulinism with cyproheptadine and diazoxide.
Topics: Blood Glucose; C-Peptide; Cyproheptadine; Diazoxide; Drug Combinations; Female; Humans; Hyperinsulin | 1992 |
Diazoxide--an orphan drug?
Topics: Child, Preschool; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant; Orphan Drug Production | 1992 |
[Organic hyperinsulinism. Clinical aspects--diagnosis--therapy].
Topics: Adolescent; Adult; Aged; Child; Combined Modality Therapy; Diagnosis, Differential; Diazoxide; Femal | 1991 |
Familial hyperinsulinism: successful conservative management.
Topics: Adolescent; Child, Preschool; Diazoxide; Female; Glucagon; Humans; Hyperinsulinism; Infant; Infant, | 1991 |
Hypertrophic cardiomyopathy after prolonged diazoxide therapy for hyperinsulinemic hypoglycemia.
Topics: Adolescent; Cardiomyopathy, Hypertrophic; Diazoxide; Echocardiography; Humans; Hyperinsulinism; Hypo | 1991 |
Surgical management of islet cell dysmaturation syndrome in young children.
Topics: Adenoma; Combined Modality Therapy; Diazoxide; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; I | 1990 |
Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome.
Topics: Blood Glucose; Diazoxide; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Huma | 1989 |
[The Biostator in the diagnosis and therapy of organic hyperinsulinism].
Topics: Adult; Aged; Blood Glucose; Diazoxide; Female; Humans; Hyperinsulinism; Insulin; Insulin Infusion Sy | 1989 |
Complications of diazoxide treatment in persistent neonatal hyperinsulinism.
Topics: Blood Glucose; Diazoxide; Female; Heart Failure; Humans; Hyperinsulinism; Hypoglycemia; Infant; Insu | 1989 |
Hyperinsulinism in infancy.
Topics: Diazoxide; Diuretics; Female; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Male; Pancreas | 1989 |
The hyperinsulinaemic hypoglycaemias in infancy: a study of six cases.
Topics: Biopsy; Blood Glucose; Diagnosis, Differential; Diazoxide; Female; Glucose Tolerance Test; Humans; H | 1988 |
Ineffectiveness of SMS 201-995 in severe hyperinsulinemia.
Topics: Aged; Blood Glucose; Diazoxide; Female; Humans; Hyperinsulinism; Insulin; Insulinoma; Middle Aged; O | 1988 |
Long-term treatment with diazoxide in childhood hyperinsulinism.
Topics: Diazoxide; Humans; Hyperinsulinism; Hypoglycemia; Infant; Infant, Newborn; Intellectual Disability; | 1986 |
The diagnosis of hyperinsulinism in a child in the absence of hyperinsulinemia.
Topics: Adolescent; Diazoxide; Fatty Acids, Nonesterified; Female; Humans; Hyperinsulinism; Hypoglycemia; In | 1986 |
Ketamine induction for a patient with hyperinsulinism treated with oral diazoxide.
Topics: Anesthesia; Diazoxide; Drug Interactions; Humans; Hyperinsulinism; Infant; Ketamine; Male | 1986 |
Persistent neonatal hyperinsulinemic hypoglycemia in two siblings successfully treated with diazoxide.
Topics: Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Infant, Newborn; Male | 1986 |
Diazoxide prevents the development of hormonal and metabolic abnormalities present in rats fed a sucrose rich diet.
Topics: Animals; Diazoxide; Dietary Carbohydrates; DNA; Glucagon; Heart; Hyperinsulinism; Insulin; Insulin R | 1985 |
Hypoglycemia due to organic hyperinsulinism in infancy.
Topics: Adenoma, Islet Cell; Adrenal Cortex Hormones; Diazoxide; Female; Humans; Hyperinsulinism; Hyperplasi | 1970 |
[Action of diazoxide in a severe case of hyperinsulinism due to an operated Langerhansian carcinoma complicated by hepatic metastases].
Topics: Adenoma, Islet Cell; Diazoxide; Female; Humans; Hyperinsulinism; Middle Aged; Pancreatectomy; Postop | 1966 |
Insulin-secreting bronchial carcinoid tumor with widespread metastases.
Topics: Adult; Blood Glucose; Bronchi; Bronchial Neoplasms; Carcinoma, Adenoid Cystic; Diazoxide; Female; Gl | 1968 |
Further studies on diazoxide suppression of insulin release from abnormal and normal islet tissue in man.
Topics: Adenoma, Islet Cell; Arginine; Blood Glucose; Catecholamines; Depression, Chemical; Diazoxide; Femal | 1968 |
Inhibition of insulin release by diazoxide and its relation to catecholamine effects in man.
Topics: Adenoma, Islet Cell; Blood Glucose; Catecholamines; Diazoxide; Drug Synergism; Fatty Acids, Nonester | 1968 |
Clinical use of diazoxide and studies of the mechanism of its hyperglycemic effects in man.
Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Diabetes Mellitus; Diazoxide; Fatty Acids, Nonesterified; | 1968 |
Metabolic effects of diazoxide in normal subjects, patients with diabetes mellitus, and patients with organic hypoglycemia.
Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; Diabetes Mellitus; Diazoxide; Fatty Acids, Nonester | 1968 |
[Insulin-secreting langerhansian beta-cell tumor in a woman with diabetes mellitus. Case report and literature review].
Topics: Adenoma, Islet Cell; Diabetes Complications; Diabetic Angiopathies; Diazoxide; Humans; Hyperinsulini | 1969 |
[Organic hypoglycemia in association with a malignant tumor and an islet cell adenoma. Determining role of blood insulin determination for the etiologic diagnosis and surgical procedure].
Topics: Adenoma; Adenoma, Islet Cell; Aged; Arginine; Carcinoma; Diazoxide; Female; Glucagon; Glucose Tolera | 1969 |
Pancreatic islet cell carcinoma with hyperinsulinism and probable, ectopic ACTH-MSH secretion.
Topics: Adenoma, Islet Cell; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Blood Glucose; Diazoxide; Gl | 1969 |
[Continuous treatment with diazoxide of hypoglycemia due to hyperinsulinism].
Topics: Aged; Diazoxide; Female; Humans; Hyperinsulinism; Hypoglycemia; Mental Disorders; Obesity | 1970 |
[Surgical and conservative treatment of hyperinsulinism].
Topics: Adenoma, Islet Cell; Adrenocorticotropic Hormone; Adult; Diagnosis, Differential; Diazoxide; Female; | 1971 |
[Islet cell adenoma].
Topics: Adenoma, Islet Cell; Adult; Aged; Angiography; Blood Glucose; Diazoxide; Female; Humans; Hyperinsuli | 1971 |
Surgical grand rounds from the University of Mississippi Medical Center. Management of hyperinsulinism.
Topics: Adenoma, Islet Cell; Diagnosis, Differential; Diazoxide; Dietary Carbohydrates; Female; Glucose Tole | 1971 |
Hypoglycemia due to hyperinsulinism treated by streptozotocin and diazoxide.
Topics: Adenoma, Islet Cell; Adult; Anti-Bacterial Agents; Diazoxide; Drug Synergism; Female; Humans; Hyperi | 1972 |
Pancreatic islet beta cell tumors and hyperplasia: experience in 14 Seattle hospitals.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Diazoxide; Female; Humans; Hyperinsulinism; Hyp | 1972 |
[Hyperinsulinism due to metastasizing insuloma treated with diazoxide and streptozotocin].
Topics: Adenoma, Islet Cell; Blood Glucose; Diazoxide; Female; Humans; Hyperinsulinism; Insulin; Liver Neopl | 1972 |
Pluriglandular syndrome with hyperinsulinism. Cardiomegaly as a possible complication of diazoxide therapy.
Topics: Blood Glucose; Blood Pressure; Cardiomegaly; Child; Diazoxide; Female; Hirsutism; Humans; Hypercalce | 1968 |
[Endocrine polyadenomatosis. General review and case report].
Topics: Adenoma; Adenoma, Islet Cell; Diazoxide; Female; Humans; Hydronephrosis; Hyperinsulinism; Hypoglycem | 1969 |
[Treatment of hyperinsulinism with diazoxide over several years].
Topics: Aged; Diazoxide; Evaluation Studies as Topic; Female; Humans; Hypercholesterolemia; Hyperinsulinism; | 1972 |
Metabolic aspects of the Beckwith-Wiedemann syndrome.
Topics: Abnormalities, Multiple; Adrenal Gland Diseases; Blood Glucose; Child, Preschool; Diazoxide; Epineph | 1973 |
Diazoxide therapy in the syndrome of Beckwith-Weidemann-Coombs.
Topics: Abnormalities, Multiple; Adrenal Gland Diseases; Blood Glucose; Child, Preschool; Diazoxide; Epineph | 1973 |
Chlorpromazine in the treatment of endogenous organic hyperinsulinism.
Topics: Adult; Bendroflumethiazide; Blood Glucose; Chlorpromazine; Diazoxide; Female; Glucose Tolerance Test | 1974 |
[Diazoxide in the therapy of leucin sensitive hypoglycemia].
Topics: Carbohydrate Metabolism, Inborn Errors; Diazoxide; Humans; Hyperinsulinism; Hypertrichosis; Hypoglyc | 1971 |
[Hyperinsulinism treated with diazoxide].
Topics: Aged; Blood Glucose; Diazoxide; Female; Humans; Hyperinsulinism; Insulin; Methods; Time Factors | 1969 |
Diazoxide for hyperinsulinism.
Topics: Adult; Animals; Child; Diazoxide; Humans; Hyperinsulinism; Hypoglycemia | 1970 |
AO44: an improved hyperglycemic agent.
Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Diazoxide; Diuresis; Dogs; Epinephrine | 1971 |
[Clinical observations and experimental findings in the treatment of hyperinsulinism with diazoxide].
Topics: Animals; Diazoxide; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemia | 1967 |