diazoxide has been researched along with Cerebral Ischemia in 23 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the effects of diazoxide on oxygen free radicals and cell apoptosis in brain tissue after deep hypothermia cerebral ischemia reperfusion injury in young rats." | 7.76 | [Effect of diazoxide on oxygen free radicals and cell apoptosis in brain tissue after deep hypothermia cerebral ischemia reperfusion injury in young rats]. ( Chen, F; Gu, HT; Gu, Q; He, XM; Mo, XM; Peng, W; Qi, JR; Sun, J; Zhang, YS, 2010) |
| " We tested whether Diaz preserves endothelium-dependent (hypercapnia) or -independent [iloprost (Ilo)] cerebrovascular dilator responses after ischemia-reperfusion (I/R) in newborn pigs and whether the effect of Diaz is sensitive to 5-hydroxydecanoate (5-HD), an inhibitor of mitoKATP channels." | 7.73 | Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. ( Bari, F; Busija, DW; Domoki, F; Farkas, E; Kis, B; Nagy, K, 2005) |
| " We investigated the effects of mitoK(ATP) channel opener diazoxide on BBB functions during ischemia/reperfusion injury (I/R)." | 7.73 | Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability. ( Bari, F; Busija, DW; Kis, B; Lenzsér, G, 2005) |
| "Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke." | 5.40 | Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels. ( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014) |
| "To determine the effects of diazoxide on oxygen free radicals and cell apoptosis in brain tissue after deep hypothermia cerebral ischemia reperfusion injury in young rats." | 3.76 | [Effect of diazoxide on oxygen free radicals and cell apoptosis in brain tissue after deep hypothermia cerebral ischemia reperfusion injury in young rats]. ( Chen, F; Gu, HT; Gu, Q; He, XM; Mo, XM; Peng, W; Qi, JR; Sun, J; Zhang, YS, 2010) |
| " We tested whether Diaz preserves endothelium-dependent (hypercapnia) or -independent [iloprost (Ilo)] cerebrovascular dilator responses after ischemia-reperfusion (I/R) in newborn pigs and whether the effect of Diaz is sensitive to 5-hydroxydecanoate (5-HD), an inhibitor of mitoKATP channels." | 3.73 | Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. ( Bari, F; Busija, DW; Domoki, F; Farkas, E; Kis, B; Nagy, K, 2005) |
| " We investigated the effects of mitoK(ATP) channel opener diazoxide on BBB functions during ischemia/reperfusion injury (I/R)." | 3.73 | Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability. ( Bari, F; Busija, DW; Kis, B; Lenzsér, G, 2005) |
| "Diazoxide is a putative mitochondrial, ATP-sensitive potassium channel opener that has been implicated in neuroprotection in cerebral ischemia." | 3.73 | Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion. ( Bari, F; Domoki, F; Farkas, E; Luiten, PG; Mihály, A; Timmer, NM, 2005) |
| "The effect on cerebral blood flow of acute diazoxide-induced hypotension was studied in rats with renal and spontaneous hypertension." | 3.66 | Effect of diazoxide-induced hypotension on cerebral blood flow in hypertensive rats. ( Barry, DI; Bolwig, TG; Braendstrup, O; Graham, DI; Strandgaard, S; Svendsen, UG, 1983) |
| "Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke." | 1.40 | Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels. ( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014) |
| "A causal link between cerebral ischemia and WM damage has been demonstrated in rats; however, few attempts appear to have been made to test potential drugs for the alleviation of ischemia-related WM injury." | 1.33 | Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain. ( Annaházi, A; Bari, F; Farkas, E; Institóris, A; Luiten, PG; Mihály, A, 2005) |
| "Diazoxide has been identified as a mitochondrial, ATP-dependent K(+) channel opener, and a potentially neuroprotective compound under ischemic conditions." | 1.33 | The effect of pre- and posttreatment with diazoxide on the early phase of chronic cerebral hypoperfusion in the rat. ( Bari, F; Domoki, F; Farkas, E; Institóris, A; Mihály, A, 2006) |
| "Pretreatment with diazoxide protected both Sur1KO and wild-type neurons, while 5-hydroxydecanoate augmented neurodegeneration in both strains of animals when administered before a 20-minute bout of ischemia." | 1.32 | Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels. ( Aguilar-Bryan, L; Barrios, R; Bryan, J; Goodman, JC; Muñoz, A; Nakazaki, M; Onetti, CG, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 14 (60.87) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haapanen, HJ | 1 |
| Arvola, O | 1 |
| Herajärvi, J | 1 |
| Anttila, T | 1 |
| Tuominen, H | 1 |
| Puistola, U | 1 |
| Karihtala, P | 1 |
| Kiviluoma, K | 1 |
| Juvonen, T | 1 |
| Anttila, V | 1 |
| Lei, X | 1 |
| Lei, L | 1 |
| Zhang, Z | 1 |
| Cheng, Y | 1 |
| Yang, Z | 1 |
| Chen, Y | 1 |
| Zhang, Y | 1 |
| Jiang, Y | 1 |
| Fang, X | 1 |
| Xu, J | 1 |
| Watanabe, M | 1 |
| Katsura, K | 1 |
| Ohsawa, I | 1 |
| Mizukoshi, G | 1 |
| Takahashi, K | 1 |
| Asoh, S | 1 |
| Ohta, S | 1 |
| Katayama, Y | 1 |
| He, XM | 1 |
| Mo, XM | 1 |
| Gu, Q | 1 |
| Chen, F | 1 |
| Zhang, YS | 1 |
| Peng, W | 1 |
| Qi, JR | 1 |
| Gu, HT | 1 |
| Sun, J | 1 |
| Shen, F | 1 |
| Wu, LP | 1 |
| Liu, WG | 1 |
| Lu, Y | 1 |
| Liang, HW | 1 |
| Xia, Q | 1 |
| Shimizu, K | 1 |
| Lacza, Z | 1 |
| Rajapakse, N | 1 |
| Horiguchi, T | 1 |
| Snipes, J | 1 |
| Busija, DW | 5 |
| Muñoz, A | 1 |
| Nakazaki, M | 1 |
| Goodman, JC | 1 |
| Barrios, R | 1 |
| Onetti, CG | 1 |
| Bryan, J | 1 |
| Aguilar-Bryan, L | 1 |
| Liu, D | 2 |
| Slevin, JR | 1 |
| Lu, C | 2 |
| Chan, SL | 1 |
| Hansson, M | 1 |
| Elmér, E | 1 |
| Mattson, MP | 2 |
| Nakagawa, I | 1 |
| Ogawa, Y | 1 |
| Noriyama, Y | 1 |
| Nakase, H | 1 |
| Yamashita, M | 1 |
| Sakaki, T | 1 |
| Domoki, F | 5 |
| Bari, F | 7 |
| Nagy, K | 2 |
| Siklós, L | 1 |
| Farkas, E | 4 |
| Annaházi, A | 1 |
| Institóris, A | 2 |
| Mihály, A | 3 |
| Luiten, PG | 2 |
| Kis, B | 2 |
| Lenzsér, G | 1 |
| Timmer, NM | 1 |
| Blanco, M | 1 |
| Lizasoain, I | 1 |
| Sobrino, T | 1 |
| Vivancos, J | 1 |
| Castillo, J | 1 |
| Barry, DI | 1 |
| Strandgaard, S | 2 |
| Graham, DI | 1 |
| Braendstrup, O | 1 |
| Svendsen, UG | 1 |
| Bolwig, TG | 1 |
| Yamada, KA | 1 |
| Covey, DF | 1 |
| Hsu, CY | 1 |
| Hu, R | 1 |
| Hu, Y | 1 |
| He, YY | 1 |
| Perciaccante, JV | 1 |
| Veltkamp, R | 1 |
| Wan, R | 1 |
| Auyeung, WW | 1 |
1 trial available for diazoxide and Cerebral Ischemia
| Article | Year |
|---|---|
Cerebral symptoms and blood pressure during parenteral administration of chlorpromazine, dihydralazine and diazoxide. Danish multicenter study on acute severe hypertension.
Topics: Blood Pressure; Brain Diseases; Brain Ischemia; Chlorpromazine; Clinical Trials as Topic; Diazoxide; | 1983 |
22 other studies available for diazoxide and Cerebral Ischemia
| Article | Year |
|---|---|
Pharmacological Preconditioning with Diazoxide in the Experimental Hypothermic Circulatory Arrest Model.
Topics: Animals; Brain Ischemia; Circulatory Arrest, Deep Hypothermia Induced; Diazoxide; Disease Models, An | 2017 |
Diazoxide inhibits of ER stress‑mediated apoptosis during oxygen‑glucose deprivation in vitro and cerebral ischemia‑reperfusion in vivo.
Topics: Animals; Apoptosis; Brain Ischemia; Diazoxide; Endoplasmic Reticulum Stress; Female; Glucose; Heat-S | 2018 |
Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels.
Topics: Animals; Body Weight; Brain; Brain Injuries; Brain Ischemia; Decanoic Acids; Diazoxide; Diet, High-F | 2014 |
Involvement of mitoKATP channel in protective mechanisms of cerebral ischemic tolerance.
Topics: Animals; Anti-Arrhythmia Agents; Brain Ischemia; Cells, Cultured; Decanoic Acids; Diazoxide; Gerbill | 2008 |
[Effect of diazoxide on oxygen free radicals and cell apoptosis in brain tissue after deep hypothermia cerebral ischemia reperfusion injury in young rats].
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Caspase 3; Circulatory Arrest, Deep Hypothermia Induced; | 2010 |
[Effect of activation of mitochondrial ATP sensitive potassium channel and calcium activated potassium channel on the permeability transition of mitochondria from both normal and ischemic rat brain].
Topics: Animals; Benzimidazoles; Brain; Brain Ischemia; Cell Membrane Permeability; Diazoxide; KATP Channels | 2007 |
MitoK(ATP) opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat.
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Diazoxide; Infarction, Middle | 2002 |
Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cell Survival; Decanoic Acids; Diazoxide; Hippocamp | 2003 |
Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Death; Cell Hypoxia; Cells, Cultured; Cyanides; Decanoic Ac | 2003 |
Chemical preconditioning prevents paradoxical increase in glutamate release during ischemia by activating ATP-dependent potassium channels in gerbil hippocampus.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Calcium; Diazoxide; Excitatory Postsynaptic Potenti | 2003 |
Diazoxide prevents mitochondrial swelling and Ca2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs.
Topics: Animals; Animals, Newborn; Brain Ischemia; Calcium; Diazoxide; Female; Male; Mitochondrial Swelling; | 2004 |
Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain.
Topics: Animals; Astrocytes; Brain Ischemia; Corpus Callosum; Diazoxide; Dimethyl Sulfoxide; Male; Rats; Rat | 2005 |
Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets.
Topics: Animals; Animals, Newborn; Arterioles; Blood Pressure; Brain Ischemia; Cells, Cultured; Cerebrovascu | 2005 |
Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Capillary Permeability; Diazoxide; | 2005 |
Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion.
Topics: Animals; Brain Infarction; Brain Ischemia; Carotid Stenosis; CD11 Antigens; Cerebrovascular Circulat | 2005 |
The effect of pre- and posttreatment with diazoxide on the early phase of chronic cerebral hypoperfusion in the rat.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Brain Ischemia; Cell Survival; Diazoxide; Diseas | 2006 |
Ischemic preconditioning: a novel target for neuroprotective therapy.
Topics: Adenosine Triphosphate; alpha-Linolenic Acid; Animals; Brain; Brain Ischemia; Clinical Trials as Top | 2006 |
Effect of diazoxide-induced hypotension on cerebral blood flow in hypertensive rats.
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Diazoxide; Hypertension; Hyper | 1983 |
Cerebral blood flow in hypertension.
Topics: Antihypertensive Agents; Brain Ischemia; Cerebrovascular Circulation; Cerebrovascular Disorders; Dia | 1983 |
The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury.
Topics: Animals; Benzothiadiazines; Brain Ischemia; Cells, Cultured; Diazoxide; Diuretics; Excitatory Amino | 1998 |
Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs.
Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Decanoic Acids; Diazoxide; Dose-Response Rela | 1999 |
Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Brain Ischemia; Cell Survival; Cells, Culture | 2002 |