diazoxide has been researched along with Cardiovascular Stroke in 58 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, and if so, whether the effects could be mediated by mitochondrial ATP-sensitive potassium (m-KATP) channels." | 7.78 | High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels. ( Cho, S; Higashijima, U; Ichinomiya, T; Maekawa, T; Matsumoto, S; Sumikawa, K, 2012) |
| "Angiotensin II (Ang II) and tumour necrosis factor alpha (TNFalpha) are involved in the progression from compensated hypertrophy to heart failure." | 7.75 | Angiotensin II and tumour necrosis factor alpha as mediators of ATP-dependent potassium channel remodelling in post-infarction heart failure. ( Baertschi, AJ; Isidoro Tavares, N; Lerch, R; Montessuit, C; Philip-Couderc, P, 2009) |
| "Twenty patients with blood pressure over 180/110 mm Hg one hour after admission to a coronary care unit with recent acute myocardial infarction were given intravenous diazoxide in a bolus of 300 mg." | 7.65 | Intravenous diazoxide in treatment of hypertension associated with recent myocardial infarction. ( Grigor, RR; O'Brien, KP; Taylor, PM, 1975) |
| " In addition, the myocardial infarct size was significantly smaller in diazoxide-treated acute myocardial infarction rats compared with untreated rats." | 4.31 | Effects of Mitochondrial ATP-Sensitive Potassium Channel in Rats with Acute Myocardial Infarction and Its Association with the AKT/mTOR Pathway. ( Chen, QF; Huang, DL; Huang, Z; Nong, J; Wang, F; Wang, W; Yang, F; Yang, J; Zeng, J; Zeng, Q; Zhang, LD, 2023) |
| "The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, and if so, whether the effects could be mediated by mitochondrial ATP-sensitive potassium (m-KATP) channels." | 3.78 | High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels. ( Cho, S; Higashijima, U; Ichinomiya, T; Maekawa, T; Matsumoto, S; Sumikawa, K, 2012) |
| "Angiotensin II (Ang II) and tumour necrosis factor alpha (TNFalpha) are involved in the progression from compensated hypertrophy to heart failure." | 3.75 | Angiotensin II and tumour necrosis factor alpha as mediators of ATP-dependent potassium channel remodelling in post-infarction heart failure. ( Baertschi, AJ; Isidoro Tavares, N; Lerch, R; Montessuit, C; Philip-Couderc, P, 2009) |
| " Preconditioning with 10 microM adenosine limited necrosis (10." | 3.72 | Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects. ( Headrick, JP; Peart, J, 2003) |
| " The purpose of this study was to examine the effects of the mitochondrial potassium ATP-sensitive channel opener diazoxide on regional and global myocardial protection using a model of acute myocardial infarction." | 3.71 | Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis. ( Cowan, DB; Federman, M; Levitsky, S; McCully, JD; Toyoda, Y; Wakiyama, H, 2002) |
| "Twenty patients with blood pressure over 180/110 mm Hg one hour after admission to a coronary care unit with recent acute myocardial infarction were given intravenous diazoxide in a bolus of 300 mg." | 3.65 | Intravenous diazoxide in treatment of hypertension associated with recent myocardial infarction. ( Grigor, RR; O'Brien, KP; Taylor, PM, 1975) |
| "Pretreatment with diazoxide (100 microM), a selective mK(ATP) channel opener, for 5 min followed by 10 min washout before the 30-min ischemia and 2-h reperfusion significantly reduced infarct size (9 +/- 3 vs." | 1.31 | Dual roles of mitochondrial K(ATP) channels in diazoxide-mediated protection in isolated rabbit hearts. ( Cone, J; Liu, Y; Wang, S, 2001) |
| "Hyperglycemia is an important predictor of cardiovascular mortality in patients with diabetes." | 1.31 | Diabetes and hyperglycemia impair activation of mitochondrial K(ATP) channels. ( Ghassemi, T; Gross, ER; Kersten, JR; Montgomery, MW; Pagel, PS; Toller, WG; Warltier, DC, 2001) |
| "Glimepiride (Glim) is a new sulfonylurea reported to affect nonpancreatic K(ATP) channels less than does Glib." | 1.31 | Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide. ( Baxter, GF; Lawrence, CL; Maddock, HL; Mocanu, MM; Standen, NB; Yellon, DM, 2001) |
| "Pretreatment with diazoxide (100 microM) with a 10-min washout period reduced %IS/LV to 7." | 1.31 | Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction. ( Genda, S; Kuno, A; Matsumoto, T; Miki, T; Miura, T; Nozawa, Y; Shimamoto, K; Tanno, M; Tsuchida, A, 2001) |
| "Diazoxide (1 mg/kg) was administered either 30 min (for EP) or 24 h (DP) before 30 min of lethal ischemia." | 1.30 | Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide. ( Brown, M; Emani, VR; Krottapalli, K; Kukreja, RC; Ockaili, R; Okubo, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (13.79) | 18.7374 |
| 1990's | 1 (1.72) | 18.2507 |
| 2000's | 36 (62.07) | 29.6817 |
| 2010's | 12 (20.69) | 24.3611 |
| 2020's | 1 (1.72) | 2.80 |
| Authors | Studies |
|---|---|
| Zeng, Q | 1 |
| Zhang, LD | 1 |
| Chen, QF | 1 |
| Wang, W | 1 |
| Huang, Z | 1 |
| Huang, DL | 1 |
| Wang, F | 1 |
| Yang, F | 1 |
| Nong, J | 1 |
| Yang, J | 1 |
| Zeng, J | 1 |
| Makepeace, CM | 1 |
| Suarez-Pierre, A | 1 |
| Kanter, EM | 1 |
| Schuessler, RB | 1 |
| Nichols, CG | 1 |
| Lawton, JS | 1 |
| Csonka, C | 1 |
| Kupai, K | 1 |
| Bencsik, P | 1 |
| Görbe, A | 1 |
| Pálóczi, J | 1 |
| Zvara, A | 1 |
| Puskás, LG | 1 |
| Csont, T | 1 |
| Ferdinandy, P | 1 |
| Mehmood, A | 1 |
| Ali, M | 1 |
| Khan, SN | 1 |
| Riazuddin, S | 1 |
| Isidoro Tavares, N | 2 |
| Philip-Couderc, P | 2 |
| Baertschi, AJ | 2 |
| Lerch, R | 2 |
| Montessuit, C | 2 |
| Afzal, MR | 1 |
| Haider, HKh | 2 |
| Idris, NM | 2 |
| Jiang, S | 2 |
| Ahmed, RP | 2 |
| Ashraf, M | 3 |
| Cui, X | 1 |
| Wang, H | 1 |
| Guo, H | 1 |
| Wang, C | 1 |
| Ao, H | 1 |
| Liu, X | 1 |
| Tan, YZ | 1 |
| Rodríguez-Sinovas, A | 1 |
| Sánchez, JA | 1 |
| González-Loyola, A | 1 |
| Barba, I | 1 |
| Morente, M | 1 |
| Aguilar, R | 1 |
| Agulló, E | 1 |
| Miró-Casas, E | 1 |
| Esquerda, N | 1 |
| Ruiz-Meana, M | 1 |
| García-Dorado, D | 1 |
| Haider, KH | 1 |
| Kim, HW | 1 |
| Shujia, J | 1 |
| González, G | 1 |
| Zaldívar, D | 1 |
| Carrillo, E | 1 |
| Hernández, A | 1 |
| García, M | 1 |
| Sánchez, J | 1 |
| Terashima, Y | 1 |
| Sato, T | 1 |
| Yano, T | 1 |
| Maas, O | 1 |
| Itoh, T | 1 |
| Miki, T | 2 |
| Tanno, M | 2 |
| Kuno, A | 2 |
| Shimamoto, K | 2 |
| Miura, T | 2 |
| Vigneron, F | 1 |
| Dos Santos, P | 1 |
| Lemoine, S | 1 |
| Bonnet, M | 1 |
| Tariosse, L | 1 |
| Couffinhal, T | 1 |
| Duplaà, C | 1 |
| Jaspard-Vinassa, B | 1 |
| Nuñez, IP | 1 |
| Fantinelli, J | 1 |
| Arbeláez, LF | 1 |
| Mosca, SM | 1 |
| Ichinomiya, T | 1 |
| Cho, S | 1 |
| Higashijima, U | 1 |
| Matsumoto, S | 1 |
| Maekawa, T | 1 |
| Sumikawa, K | 1 |
| Smith, RM | 1 |
| Suleman, N | 1 |
| McCarthy, J | 1 |
| Sack, MN | 1 |
| Neckár, J | 1 |
| Szárszoi, O | 1 |
| Koten, L | 1 |
| Papousek, F | 1 |
| Ost'ádal, B | 1 |
| Grover, GJ | 2 |
| Kolár, F | 1 |
| Yue, Y | 2 |
| Qin, Q | 1 |
| Cohen, MV | 3 |
| Downey, JM | 3 |
| Critz, SD | 2 |
| Patel, HH | 1 |
| Ludwig, LM | 1 |
| Fryer, RM | 2 |
| Hsu, AK | 2 |
| Warltier, DC | 3 |
| Gross, GJ | 3 |
| Schwartz, LM | 1 |
| Welch, TS | 1 |
| Crago, MS | 1 |
| Sasaki, N | 1 |
| Murata, M | 1 |
| Guo, Y | 1 |
| Jo, SH | 1 |
| Ohler, A | 1 |
| Akao, M | 1 |
| O'Rourke, B | 1 |
| Xiao, RP | 1 |
| Bolli, R | 2 |
| Marbán, E | 1 |
| Peart, J | 1 |
| Headrick, JP | 1 |
| Duncker, DJ | 1 |
| Verdouw, PD | 1 |
| Oldenburg, O | 1 |
| Yang, XM | 2 |
| Krieg, T | 1 |
| Garlid, KD | 1 |
| Irie, H | 1 |
| Gao, J | 1 |
| Gaudette, GR | 1 |
| Cohen, IS | 1 |
| Mathias, RT | 1 |
| Saltman, AE | 1 |
| Krukenkamp, IB | 1 |
| Okubo, S | 2 |
| Tanabe, Y | 1 |
| Fujioka, N | 1 |
| Takeda, K | 1 |
| Takekoshi, N | 1 |
| Wakeno-Takahashi, M | 1 |
| Otani, H | 1 |
| Nakao, S | 1 |
| Uchiyama, Y | 1 |
| Imamura, H | 1 |
| Shingu, K | 1 |
| Alcindor, D | 1 |
| Krolikowski, JG | 1 |
| Pagel, PS | 2 |
| Kersten, JR | 2 |
| Davies, JE | 1 |
| Digerness, SB | 1 |
| Killingsworth, CR | 1 |
| Zaragoza, C | 1 |
| Katholi, CR | 1 |
| Justice, RK | 1 |
| Goldberg, SP | 1 |
| Holman, WL | 1 |
| Mentzer, RM | 1 |
| Przyklenk, K | 1 |
| Maynard, M | 1 |
| Whittaker, P | 1 |
| Niagara, MI | 1 |
| Papageorgiou, I | 1 |
| Bazargan, M | 1 |
| Faghihi, M | 1 |
| Chitsaz, M | 1 |
| Penna, C | 1 |
| Mancardi, D | 1 |
| Raimondo, S | 1 |
| Geuna, S | 1 |
| Pagliaro, P | 1 |
| Shahid, M | 1 |
| Tauseef, M | 1 |
| Sharma, KK | 1 |
| Fahim, M | 1 |
| Mozaffari, MS | 1 |
| Schaffer, SW | 1 |
| Gauthier, KM | 1 |
| Moore, J | 1 |
| Falck, JR | 1 |
| Hammock, BD | 1 |
| Campbell, WB | 1 |
| Nithipatikom, K | 1 |
| Grossman, SH | 1 |
| Gunnells, JC | 1 |
| Bender, F | 1 |
| Ockaili, R | 1 |
| Emani, VR | 1 |
| Brown, M | 1 |
| Krottapalli, K | 1 |
| Kukreja, RC | 1 |
| Eells, JT | 1 |
| Henry, MM | 1 |
| Pain, T | 1 |
| Nakano, A | 1 |
| Liu, GS | 1 |
| Heusch, G | 1 |
| Takano, H | 1 |
| Tang, XL | 1 |
| Hale, SL | 1 |
| Kloner, RA | 1 |
| Wang, S | 1 |
| Cone, J | 1 |
| Liu, Y | 1 |
| Sanada, S | 1 |
| Kitakaze, M | 1 |
| Asanuma, H | 1 |
| Harada, K | 1 |
| Ogita, H | 1 |
| Node, K | 1 |
| Takashima, S | 1 |
| Sakata, Y | 1 |
| Asakura, M | 1 |
| Shinozaki, Y | 1 |
| Mori, H | 1 |
| Kuzuya, T | 1 |
| Hori, M | 1 |
| Montgomery, MW | 1 |
| Ghassemi, T | 1 |
| Gross, ER | 1 |
| Toller, WG | 1 |
| Toyoda, Y | 2 |
| Levitsky, S | 2 |
| McCully, JD | 2 |
| Mocanu, MM | 1 |
| Maddock, HL | 1 |
| Baxter, GF | 1 |
| Lawrence, CL | 1 |
| Standen, NB | 1 |
| Yellon, DM | 2 |
| Schulman, D | 1 |
| Latchman, DS | 1 |
| Tsuchida, A | 1 |
| Nozawa, Y | 1 |
| Genda, S | 1 |
| Matsumoto, T | 1 |
| Wakiyama, H | 1 |
| Cowan, DB | 1 |
| Federman, M | 1 |
| Birkenhäger, WH | 1 |
| Kho, TL | 1 |
| Kolsters, G | 1 |
| Schalekamp, MA | 1 |
| Wester, A | 1 |
| Zaal, GA | 1 |
| Falko, JM | 1 |
| Watt, JB | 1 |
| Mroczek, WJ | 1 |
| Kumar, GK | 1 |
| Dastoor, FC | 1 |
| Robayo, JR | 1 |
| Razzaque, MA | 1 |
| O'Brien, KP | 1 |
| Grigor, RR | 1 |
| Taylor, PM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metabolomic Profile of Patients Undergoing Myocardial Perfusion SPECT[NCT02968771] | 500 participants (Anticipated) | Observational | 2016-11-30 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for diazoxide and Cardiovascular Stroke
| Article | Year |
|---|---|
The paradigm of postconditioning to protect the heart.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Coronary Occlusion; Diazoxide; Humans; Models, Cardiova | 2008 |
Recognition and treatment of hypertensive emergencies.
Topics: Anticoagulants; Brain Diseases; Cerebrovascular Disorders; Coronary Disease; Diagnosis, Differential | 1981 |
56 other studies available for diazoxide and Cardiovascular Stroke
| Article | Year |
|---|---|
Effects of Mitochondrial ATP-Sensitive Potassium Channel in Rats with Acute Myocardial Infarction and Its Association with the AKT/mTOR Pathway.
Topics: Animals; Diazoxide; Mammals; Myocardial Infarction; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt | 2023 |
Superior diastolic function with K
Topics: Animals; Cardiotonic Agents; Coronary Vessels; Diastole; Diazoxide; Disease Models, Animal; Heart; H | 2018 |
Cholesterol-enriched diet inhibits cardioprotection by ATP-sensitive K+ channel activators cromakalim and diazoxide.
Topics: Adenosine Triphosphate; Animals; Cardiotonic Agents; Cholesterol, Dietary; Cromakalim; Decanoic Acid | 2014 |
Diazoxide preconditioning of endothelial progenitor cells improves their ability to repair the infarcted myocardium.
Topics: Animals; Apoptosis; Cell Culture Techniques; Cell Survival; Chemokine CXCL12; Diazoxide; Endothelial | 2015 |
Angiotensin II and tumour necrosis factor alpha as mediators of ATP-dependent potassium channel remodelling in post-infarction heart failure.
Topics: Action Potentials; Angiotensin II; Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Diaz | 2009 |
Preconditioning promotes survival and angiomyogenic potential of mesenchymal stem cells in the infarcted heart via NF-kappaB signaling.
Topics: Androstadienes; Animals; Cell Survival; Diazoxide; Disease Models, Animal; Echocardiography; Female; | 2010 |
Transplantation of mesenchymal stem cells preconditioned with diazoxide, a mitochondrial ATP-sensitive potassium channel opener, promotes repair of myocardial infarction in rats.
Topics: Animals; Apoptosis; Cell Count; Cell Survival; Collagen; Cytochromes c; Cytoprotection; Decanoic Aci | 2010 |
Effects of substitution of Cx43 by Cx32 on myocardial energy metabolism, tolerance to ischaemia and preconditioning protection.
Topics: Animals; Connexin 43; Connexins; Diazoxide; Energy Metabolism; Female; Gap Junction beta-1 Protein; | 2010 |
MicroRNA-21 is a key determinant in IL-11/Stat3 anti-apoptotic signalling pathway in preconditioning of skeletal myoblasts.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Survival; Cells, Cultured; Diazoxide; Disease Models, | 2010 |
Pharmacological preconditioning by diazoxide downregulates cardiac L-type Ca(2+) channels.
Topics: Action Potentials; Animals; Blotting, Western; Calcium Channels, L-Type; Calcium Signaling; Diazoxid | 2010 |
Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial K ATP channel.
Topics: Adenosine A2 Receptor Antagonists; Animals; Cyclophilins; Diazoxide; Glycogen Synthase Kinase 3; Gly | 2010 |
GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Cycle Proteins; Diazoxide; Dis | 2011 |
Mitochondrial KATP channels participate in the limitation of infarct size by cariporide.
Topics: Animals; Calcium; Cardiotonic Agents; Decanoic Acids; Diazoxide; Disease Models, Animal; Guanidines; | 2011 |
High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Glucose; Decanoic Acids; Diazoxide; Do | 2012 |
Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha gene.
Topics: Adenosine; Analysis of Variance; Animals; Decanoic Acids; Diazoxide; Hydroxy Acids; Ischemic Precond | 2002 |
Effects of mitochondrial K(ATP) modulators on cardioprotection induced by chronic high altitude hypoxia in rats.
Topics: Altitude; Analysis of Variance; Animals; Benzopyrans; Chronic Disease; Decanoic Acids; Diazoxide; Hy | 2002 |
The relative order of mK(ATP) channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heart.
Topics: Animals; Anisomycin; Decanoic Acids; Diazoxide; Enzyme Activators; Enzyme Inhibitors; Free Radical S | 2002 |
Delta opioid agonists and volatile anesthetics facilitate cardioprotection via potentiation of K(ATP) channel opening.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Benzamides; Cardiotonic Agents; Diazoxide; | 2002 |
Cardioprotection by multiple preconditioning cycles does not require mitochondrial K(ATP) channels in pigs.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiotonic Agents; Decanoi | 2002 |
MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning.
Topics: Adenosine Triphosphate; Animals; Cardiotonic Agents; Cell Membrane; Cells, Cultured; Diazoxide; Elec | 2003 |
Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects.
Topics: Adenosine; Adenosine Diphosphate; Alkaloids; Animals; Benzophenanthridines; Calcium Channel Blockers | 2003 |
Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice.
Topics: Adenosine Triphosphate; Animals; Cardiotonic Agents; Diazoxide; Disease Models, Animal; Dose-Respons | 2003 |
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
Topics: Animals; Brain Chemistry; Decanoic Acids; Diazoxide; Glyburide; Guanidines; Hydroxy Acids; Ischemic | 2003 |
Both metabolic inhibition and mitochondrial K(ATP) channel opening are myoprotective and initiate a compensatory sarcolemmal outward membrane current.
Topics: Animals; Cardiotonic Agents; Cells, Cultured; Coronary Circulation; Diazoxide; Electric Conductivity | 2003 |
Differential activation of protein kinase C between ischemic and pharmacological preconditioning in the rabbit heart.
Topics: Alkaloids; Animals; Benzophenanthridines; Cardiotonic Agents; Conditioning, Psychological; Diazoxide | 2003 |
Adenosine and a nitric oxide donor enhances cardioprotection by preconditioning with isoflurane through mitochondrial adenosine triphosphate-sensitive K+ channel-dependent and -independent mechanisms.
Topics: Adenosine; Anesthetics, Inhalation; Animals; Cardiovascular Agents; Diazoxide; Dose-Response Relatio | 2004 |
Cyclooxygenase-2 mediates ischemic, anesthetic, and pharmacologic preconditioning in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Anesthetics, Inhalation; Animals; Aspirin; Celecoxib; C | 2004 |
Multiple treatment approach to limit cardiac ischemia-reperfusion injury.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Combined Modality Therapy; Diazoxide; | 2005 |
Invited commentary.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Combined Modality Therapy; Diazoxide; | 2005 |
First molecular evidence that inositol trisphosphate signaling contributes to infarct size reduction with preconditioning.
Topics: Animals; Calcium Channels; Diazoxide; Gene Expression Regulation; Heart Ventricles; Inositol 1,4,5-T | 2006 |
Pharmacologically preconditioned skeletal myoblasts are resistant to oxidative stress and promote angiomyogenesis via release of paracrine factors in the infarcted heart.
Topics: Animals; Cell Survival; Cell Transplantation; Diazoxide; Intercellular Signaling Peptides and Protei | 2007 |
Expression and function of ATP-dependent potassium channels in late post-infarction remodeling.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Diazoxide; Electric Capacitance; Gene Expression | 2007 |
Importance of timing of magnesium administration in the isolated ischemic-reperfused rat heart: role of K(ATP) channels.
Topics: Animals; Cardiotonic Agents; Coronary Circulation; Diazoxide; Drug Administration Schedule; Glyburid | 2008 |
Brief femoral artery ischaemia provides protection against myocardial ischaemia-reperfusion injury in rats: the possible mechanisms.
Topics: Animals; Arginine; Blood Pressure; Creatine Kinase, MB Form; Diazoxide; Disease Models, Animal; Femo | 2008 |
Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore.
Topics: Animals; Cardiotonic Agents; Cyclosporine; Diazoxide; Disease Models, Animal; Glyburide; Glycogen Sy | 2008 |
Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Blood Pressure; Cardiovascular Agents; Coronary Ci | 2008 |
Acute hypertensive crises.
Topics: Acute Disease; Adult; Aged; Clonidine; Diazoxide; Heart Block; Humans; Hypertension; Injections, Int | 1980 |
Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Coronary Vessels; Decanoic Acids; Diazoxide | 1999 |
Ischemic preconditioning in rats: role of mitochondrial K(ATP) channel in preservation of mitochondrial function.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Diazoxide; Hemodynamics; Hydroxy Acids; Ischemic Pr | 2000 |
Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Decanoic Acids; | 2000 |
Differential role of K(ATP) channels in late preconditioning against myocardial stunning and infarction in rabbits.
Topics: Adenosine Triphosphate; Animals; Decanoic Acids; Diazoxide; Glyburide; Heart; Hemodynamics; Hydroxy | 2000 |
Effect of combined K(ATP) channel activation and Na(+)/H(+) exchange inhibition on infarct size in rabbits.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Decanoic Acids; Diazoxide; Guanidines; Heart Rate; | 2000 |
Dual roles of mitochondrial K(ATP) channels in diazoxide-mediated protection in isolated rabbit hearts.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Diazox | 2001 |
Role of mitochondrial and sarcolemmal K(ATP) channels in ischemic preconditioning of the canine heart.
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Collateral Circulation; Coronary Circulat | 2001 |
Diabetes and hyperglycemia impair activation of mitochondrial K(ATP) channels.
Topics: Analysis of Variance; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Coronary Circulation; | 2001 |
Opening of mitochondrial ATP-sensitive potassium channels enhances cardioplegic protection.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Cardioplegic Solutions; Diazoxide; Disease Mo | 2001 |
Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide.
Topics: Animals; Diazoxide; Glyburide; Guanosine Triphosphate; Heart; Heart Ventricles; Hemodynamics; Hypogl | 2001 |
Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.
Topics: Adenosine; Aging; Animals; Diazoxide; Diglycerides; Heart; Ischemic Preconditioning, Myocardial; Mal | 2001 |
Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Decanoic Acids; Diazoxide; Glyburide; Hydroxy | 2001 |
Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis.
Topics: Animals; Apoptosis; Cardioplegic Solutions; Diazoxide; Female; Heart Arrest, Induced; Male; Membrane | 2002 |
Haemodynamic setting of essential hypertension as a guide to management.
Topics: Antihypertensive Agents; Arteries; Blood Pressure; Cardiac Output; Clonidine; Diazoxide; Diuretics; | 1975 |
Hazards in antihypertension therapy.
Topics: Adult; Diazoxide; Humans; Hypertension; Male; Myocardial Infarction | 1977 |
Treatment for hypertensive crisis.
Topics: Acute Disease; Diazoxide; Hypertension; Myocardial Infarction | 1977 |
Side effects of diazoxide.
Topics: Acute Disease; Diazoxide; Female; Hemiplegia; Humans; Hypertension; Hypotension; Injections, Intrave | 1976 |
Diazoxide therapy: use and risks.
Topics: Angina Pectoris; Blood Pressure; Coronary Disease; Diazoxide; Dose-Response Relationship, Drug; Drug | 1976 |
Intravenous diazoxide in treatment of hypertension associated with recent myocardial infarction.
Topics: Acute Disease; Aged; Blood Pressure; Diazoxide; Electrocardiography; Female; Heart Rate; Humans; Hyp | 1975 |