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diazoxide and Cardiomegaly

diazoxide has been researched along with Cardiomegaly in 10 studies

Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
"Our results suggest that diazoxide blocks oxidative stress and reverses cardiac hypertrophy."7.96Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity. ( Araújo, MTS; Caldas, FRL; Coelho, BN; David, CEB; de Lacerda Alexandre, JV; Facundo, HT; Kowaltowski, AJ; Lucas, AMB; Ponte Viana, YI; Varela, ALN, 2020)
"Cardiac hypertrophy is associated with mitochondrial dysfunctions, which leads to heart failure if sustained."5.48The effect of Diazoxide on norepinephrine-induced cardiac hypertrophy, in vitro. ( Guven, C, 2018)
"Our results suggest that diazoxide blocks oxidative stress and reverses cardiac hypertrophy."3.96Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity. ( Araújo, MTS; Caldas, FRL; Coelho, BN; David, CEB; de Lacerda Alexandre, JV; Facundo, HT; Kowaltowski, AJ; Lucas, AMB; Ponte Viana, YI; Varela, ALN, 2020)
"The effects of diazoxide on cardiac hypertrophy and miR-132 expression were characterized in adult rats and in cardiomyocytes."3.88Protective Action of Diazoxide on Isoproterenol-Induced Hypertrophy Is Mediated by Reduction in MicroRNA-132 Expression. ( Carrillo, ED; García, MC; Hernández, A; Narasimhan, G; Sánchez, JA, 2018)
"Cardiac hypertrophy is associated with mitochondrial dysfunctions, which leads to heart failure if sustained."1.48The effect of Diazoxide on norepinephrine-induced cardiac hypertrophy, in vitro. ( Guven, C, 2018)
"Treatment with diazoxide (a mitoKATP opener, 5 mg·kg·d) normalized the levels of protein thiols and reduced glutathione, rescued superoxide dismutase activity, and significantly prevented cardiac hypertrophy."1.42Mitochondrial ATP-sensitive potassium channel opening inhibits isoproterenol-induced cardiac hypertrophy by preventing oxidative damage. ( de Figueiredo Júnior, IL; Fernandes Facundo, Hd; Gomes Marques de Sousa, TA; Kowaltowski, AJ; Lemos Caldas, FR; Martins, PR; Rocha Leite, IM; Tavarez Filgueiras, AB, 2015)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's1 (10.00)18.2507
2000's2 (20.00)29.6817
2010's5 (50.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Guven, C1
Narasimhan, G1
Carrillo, ED1
Hernández, A1
García, MC1
Sánchez, JA1
Lucas, AMB1
de Lacerda Alexandre, JV1
Araújo, MTS1
David, CEB1
Ponte Viana, YI1
Coelho, BN1
Caldas, FRL1
Varela, ALN1
Kowaltowski, AJ2
Facundo, HT1
Lemos Caldas, FR1
Rocha Leite, IM1
Tavarez Filgueiras, AB1
de Figueiredo Júnior, IL1
Gomes Marques de Sousa, TA1
Martins, PR1
Fernandes Facundo, Hd1
Newfield, RS1
Henn, MC1
Janjua, MB1
Zhang, H1
Kanter, EM1
Makepeace, CM1
Schuessler, RB1
Nichols, CG1
Lawton, JS1
Xia, Y2
Rajapurohitam, V1
Cook, MA2
Karmazyn, M2
Javadov, S1
Gan, TX1
Pang, T1
Ciampolillo, F1
Tung, DE1
Cameron, JS1
Appleyard, WJ1
Lloyd, J1

Other Studies

10 other studies available for diazoxide and Cardiomegaly

ArticleYear
The effect of Diazoxide on norepinephrine-induced cardiac hypertrophy, in vitro.
    Cellular and molecular biology (Noisy-le-Grand, France), 2018, Jul-30, Volume: 64, Issue:10

    Topics: Animals; Cardiomegaly; Cell Line; Diazoxide; Membrane Potential, Mitochondrial; Mitochondria; Norepi

2018
Protective Action of Diazoxide on Isoproterenol-Induced Hypertrophy Is Mediated by Reduction in MicroRNA-132 Expression.
    Journal of cardiovascular pharmacology, 2018, Volume: 72, Issue:5

    Topics: Animals; Animals, Newborn; Cardiomegaly; Cardiovascular Agents; Cells, Cultured; Cyclic AMP Response

2018
Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity.
    Current molecular pharmacology, 2020, Volume: 13, Issue:1

    Topics: Animals; Cardiomegaly; Diazoxide; Drug Evaluation, Preclinical; Hydrogen Peroxide; Ion Transport; Is

2020
Mitochondrial ATP-sensitive potassium channel opening inhibits isoproterenol-induced cardiac hypertrophy by preventing oxidative damage.
    Journal of cardiovascular pharmacology, 2015, Volume: 65, Issue:4

    Topics: Animals; Antioxidants; Cardiomegaly; Cardiotonic Agents; Diazoxide; Disease Models, Animal; Mice; Mi

2015
Topical sulfonylurea as a novel therapy for hypertrichosis secondary to diazoxide, and potentially for other conditions with excess hair growth.
    Medical hypotheses, 2015, Volume: 85, Issue:6

    Topics: Administration, Topical; Cardiomegaly; Diazoxide; Hair; Humans; Hypertrichosis; Mutation; Osteochond

2015
Increased tolerance to stress in cardiac expressed gain-of-function of adenosine triphosphate-sensitive potassium channel subunit Kir6.1.
    The Journal of surgical research, 2016, Volume: 206, Issue:2

    Topics: Animals; Cardiomegaly; Cell Size; Diazoxide; Genetic Markers; Hypertrichosis; KATP Channels; Mice; M

2016
Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide.
    Journal of molecular and cellular cardiology, 2004, Volume: 37, Issue:5

    Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cardiomegal

2004
Distinct KATP channels mediate the antihypertrophic effects of adenosine receptor activation in neonatal rat ventricular myocytes.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:1

    Topics: Animals; Animals, Newborn; Calcium; Cardiomegaly; Cells, Cultured; Decanoic Acids; Diazoxide; Hydrox

2007
Effects of diazoxide and glyburide on ATP-sensitive K+ channels from hypertrophied ventricular myocytes.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cardiomegaly; Cells, Cultured; Diazoxide; Gl

1992
Pluriglandular syndrome with hyperinsulinism. Cardiomegaly as a possible complication of diazoxide therapy.
    Proceedings of the Royal Society of Medicine, 1968, Dec-12, Volume: 61, Issue:12

    Topics: Blood Glucose; Blood Pressure; Cardiomegaly; Child; Diazoxide; Female; Hirsutism; Humans; Hypercalce

1968
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