diazoxide and Cardiomegaly
diazoxide has been researched along with Cardiomegaly in 10 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Our results suggest that diazoxide blocks oxidative stress and reverses cardiac hypertrophy." | 7.96 | Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity. ( Araújo, MTS; Caldas, FRL; Coelho, BN; David, CEB; de Lacerda Alexandre, JV; Facundo, HT; Kowaltowski, AJ; Lucas, AMB; Ponte Viana, YI; Varela, ALN, 2020) |
"Cardiac hypertrophy is associated with mitochondrial dysfunctions, which leads to heart failure if sustained." | 5.48 | The effect of Diazoxide on norepinephrine-induced cardiac hypertrophy, in vitro. ( Guven, C, 2018) |
"Our results suggest that diazoxide blocks oxidative stress and reverses cardiac hypertrophy." | 3.96 | Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity. ( Araújo, MTS; Caldas, FRL; Coelho, BN; David, CEB; de Lacerda Alexandre, JV; Facundo, HT; Kowaltowski, AJ; Lucas, AMB; Ponte Viana, YI; Varela, ALN, 2020) |
"The effects of diazoxide on cardiac hypertrophy and miR-132 expression were characterized in adult rats and in cardiomyocytes." | 3.88 | Protective Action of Diazoxide on Isoproterenol-Induced Hypertrophy Is Mediated by Reduction in MicroRNA-132 Expression. ( Carrillo, ED; García, MC; Hernández, A; Narasimhan, G; Sánchez, JA, 2018) |
"Cardiac hypertrophy is associated with mitochondrial dysfunctions, which leads to heart failure if sustained." | 1.48 | The effect of Diazoxide on norepinephrine-induced cardiac hypertrophy, in vitro. ( Guven, C, 2018) |
"Treatment with diazoxide (a mitoKATP opener, 5 mg·kg·d) normalized the levels of protein thiols and reduced glutathione, rescued superoxide dismutase activity, and significantly prevented cardiac hypertrophy." | 1.42 | Mitochondrial ATP-sensitive potassium channel opening inhibits isoproterenol-induced cardiac hypertrophy by preventing oxidative damage. ( de Figueiredo Júnior, IL; Fernandes Facundo, Hd; Gomes Marques de Sousa, TA; Kowaltowski, AJ; Lemos Caldas, FR; Martins, PR; Rocha Leite, IM; Tavarez Filgueiras, AB, 2015) |
Research
Studies (10)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (10.00) | 18.7374 |
1990's | 1 (10.00) | 18.2507 |
2000's | 2 (20.00) | 29.6817 |
2010's | 5 (50.00) | 24.3611 |
2020's | 1 (10.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Guven, C | 1 |
Narasimhan, G | 1 |
Carrillo, ED | 1 |
Hernández, A | 1 |
García, MC | 1 |
Sánchez, JA | 1 |
Lucas, AMB | 1 |
de Lacerda Alexandre, JV | 1 |
Araújo, MTS | 1 |
David, CEB | 1 |
Ponte Viana, YI | 1 |
Coelho, BN | 1 |
Caldas, FRL | 1 |
Varela, ALN | 1 |
Kowaltowski, AJ | 2 |
Facundo, HT | 1 |
Lemos Caldas, FR | 1 |
Rocha Leite, IM | 1 |
Tavarez Filgueiras, AB | 1 |
de Figueiredo Júnior, IL | 1 |
Gomes Marques de Sousa, TA | 1 |
Martins, PR | 1 |
Fernandes Facundo, Hd | 1 |
Newfield, RS | 1 |
Henn, MC | 1 |
Janjua, MB | 1 |
Zhang, H | 1 |
Kanter, EM | 1 |
Makepeace, CM | 1 |
Schuessler, RB | 1 |
Nichols, CG | 1 |
Lawton, JS | 1 |
Xia, Y | 2 |
Rajapurohitam, V | 1 |
Cook, MA | 2 |
Karmazyn, M | 2 |
Javadov, S | 1 |
Gan, TX | 1 |
Pang, T | 1 |
Ciampolillo, F | 1 |
Tung, DE | 1 |
Cameron, JS | 1 |
Appleyard, WJ | 1 |
Lloyd, J | 1 |
Other Studies
10 other studies available for diazoxide and Cardiomegaly
Article | Year |
---|---|
The effect of Diazoxide on norepinephrine-induced cardiac hypertrophy, in vitro.
Topics: Animals; Cardiomegaly; Cell Line; Diazoxide; Membrane Potential, Mitochondrial; Mitochondria; Norepi | 2018 |
Protective Action of Diazoxide on Isoproterenol-Induced Hypertrophy Is Mediated by Reduction in MicroRNA-132 Expression.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cardiovascular Agents; Cells, Cultured; Cyclic AMP Response | 2018 |
Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity.
Topics: Animals; Cardiomegaly; Diazoxide; Drug Evaluation, Preclinical; Hydrogen Peroxide; Ion Transport; Is | 2020 |
Mitochondrial ATP-sensitive potassium channel opening inhibits isoproterenol-induced cardiac hypertrophy by preventing oxidative damage.
Topics: Animals; Antioxidants; Cardiomegaly; Cardiotonic Agents; Diazoxide; Disease Models, Animal; Mice; Mi | 2015 |
Topical sulfonylurea as a novel therapy for hypertrichosis secondary to diazoxide, and potentially for other conditions with excess hair growth.
Topics: Administration, Topical; Cardiomegaly; Diazoxide; Hair; Humans; Hypertrichosis; Mutation; Osteochond | 2015 |
Increased tolerance to stress in cardiac expressed gain-of-function of adenosine triphosphate-sensitive potassium channel subunit Kir6.1.
Topics: Animals; Cardiomegaly; Cell Size; Diazoxide; Genetic Markers; Hypertrichosis; KATP Channels; Mice; M | 2016 |
Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cardiomegal | 2004 |
Distinct KATP channels mediate the antihypertrophic effects of adenosine receptor activation in neonatal rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Calcium; Cardiomegaly; Cells, Cultured; Decanoic Acids; Diazoxide; Hydrox | 2007 |
Effects of diazoxide and glyburide on ATP-sensitive K+ channels from hypertrophied ventricular myocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cardiomegaly; Cells, Cultured; Diazoxide; Gl | 1992 |
Pluriglandular syndrome with hyperinsulinism. Cardiomegaly as a possible complication of diazoxide therapy.
Topics: Blood Glucose; Blood Pressure; Cardiomegaly; Child; Diazoxide; Female; Hirsutism; Humans; Hypercalce | 1968 |