diazoxide has been researched along with Cardiac Hypertrophy in 10 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our results suggest that diazoxide blocks oxidative stress and reverses cardiac hypertrophy." | 7.96 | Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity. ( Araújo, MTS; Caldas, FRL; Coelho, BN; David, CEB; de Lacerda Alexandre, JV; Facundo, HT; Kowaltowski, AJ; Lucas, AMB; Ponte Viana, YI; Varela, ALN, 2020) |
| "Cardiac hypertrophy is associated with mitochondrial dysfunctions, which leads to heart failure if sustained." | 5.48 | The effect of Diazoxide on norepinephrine-induced cardiac hypertrophy, in vitro. ( Guven, C, 2018) |
| "Our results suggest that diazoxide blocks oxidative stress and reverses cardiac hypertrophy." | 3.96 | Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity. ( Araújo, MTS; Caldas, FRL; Coelho, BN; David, CEB; de Lacerda Alexandre, JV; Facundo, HT; Kowaltowski, AJ; Lucas, AMB; Ponte Viana, YI; Varela, ALN, 2020) |
| "The effects of diazoxide on cardiac hypertrophy and miR-132 expression were characterized in adult rats and in cardiomyocytes." | 3.88 | Protective Action of Diazoxide on Isoproterenol-Induced Hypertrophy Is Mediated by Reduction in MicroRNA-132 Expression. ( Carrillo, ED; García, MC; Hernández, A; Narasimhan, G; Sánchez, JA, 2018) |
| "Cardiac hypertrophy is associated with mitochondrial dysfunctions, which leads to heart failure if sustained." | 1.48 | The effect of Diazoxide on norepinephrine-induced cardiac hypertrophy, in vitro. ( Guven, C, 2018) |
| "Treatment with diazoxide (a mitoKATP opener, 5 mg·kg·d) normalized the levels of protein thiols and reduced glutathione, rescued superoxide dismutase activity, and significantly prevented cardiac hypertrophy." | 1.42 | Mitochondrial ATP-sensitive potassium channel opening inhibits isoproterenol-induced cardiac hypertrophy by preventing oxidative damage. ( de Figueiredo Júnior, IL; Fernandes Facundo, Hd; Gomes Marques de Sousa, TA; Kowaltowski, AJ; Lemos Caldas, FR; Martins, PR; Rocha Leite, IM; Tavarez Filgueiras, AB, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guven, C | 1 |
| Narasimhan, G | 1 |
| Carrillo, ED | 1 |
| Hernández, A | 1 |
| García, MC | 1 |
| Sánchez, JA | 1 |
| Lucas, AMB | 1 |
| de Lacerda Alexandre, JV | 1 |
| Araújo, MTS | 1 |
| David, CEB | 1 |
| Ponte Viana, YI | 1 |
| Coelho, BN | 1 |
| Caldas, FRL | 1 |
| Varela, ALN | 1 |
| Kowaltowski, AJ | 2 |
| Facundo, HT | 1 |
| Lemos Caldas, FR | 1 |
| Rocha Leite, IM | 1 |
| Tavarez Filgueiras, AB | 1 |
| de Figueiredo Júnior, IL | 1 |
| Gomes Marques de Sousa, TA | 1 |
| Martins, PR | 1 |
| Fernandes Facundo, Hd | 1 |
| Newfield, RS | 1 |
| Henn, MC | 1 |
| Janjua, MB | 1 |
| Zhang, H | 1 |
| Kanter, EM | 1 |
| Makepeace, CM | 1 |
| Schuessler, RB | 1 |
| Nichols, CG | 1 |
| Lawton, JS | 1 |
| Xia, Y | 2 |
| Rajapurohitam, V | 1 |
| Cook, MA | 2 |
| Karmazyn, M | 2 |
| Javadov, S | 1 |
| Gan, TX | 1 |
| Pang, T | 1 |
| Ciampolillo, F | 1 |
| Tung, DE | 1 |
| Cameron, JS | 1 |
| Appleyard, WJ | 1 |
| Lloyd, J | 1 |
10 other studies available for diazoxide and Cardiac Hypertrophy
| Article | Year |
|---|---|
The effect of Diazoxide on norepinephrine-induced cardiac hypertrophy, in vitro.
Topics: Animals; Cardiomegaly; Cell Line; Diazoxide; Membrane Potential, Mitochondrial; Mitochondria; Norepi | 2018 |
Protective Action of Diazoxide on Isoproterenol-Induced Hypertrophy Is Mediated by Reduction in MicroRNA-132 Expression.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cardiovascular Agents; Cells, Cultured; Cyclic AMP Response | 2018 |
Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity.
Topics: Animals; Cardiomegaly; Diazoxide; Drug Evaluation, Preclinical; Hydrogen Peroxide; Ion Transport; Is | 2020 |
Mitochondrial ATP-sensitive potassium channel opening inhibits isoproterenol-induced cardiac hypertrophy by preventing oxidative damage.
Topics: Animals; Antioxidants; Cardiomegaly; Cardiotonic Agents; Diazoxide; Disease Models, Animal; Mice; Mi | 2015 |
Topical sulfonylurea as a novel therapy for hypertrichosis secondary to diazoxide, and potentially for other conditions with excess hair growth.
Topics: Administration, Topical; Cardiomegaly; Diazoxide; Hair; Humans; Hypertrichosis; Mutation; Osteochond | 2015 |
Increased tolerance to stress in cardiac expressed gain-of-function of adenosine triphosphate-sensitive potassium channel subunit Kir6.1.
Topics: Animals; Cardiomegaly; Cell Size; Diazoxide; Genetic Markers; Hypertrichosis; KATP Channels; Mice; M | 2016 |
Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cardiomegal | 2004 |
Distinct KATP channels mediate the antihypertrophic effects of adenosine receptor activation in neonatal rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Calcium; Cardiomegaly; Cells, Cultured; Decanoic Acids; Diazoxide; Hydrox | 2007 |
Effects of diazoxide and glyburide on ATP-sensitive K+ channels from hypertrophied ventricular myocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cardiomegaly; Cells, Cultured; Diazoxide; Gl | 1992 |
Pluriglandular syndrome with hyperinsulinism. Cardiomegaly as a possible complication of diazoxide therapy.
Topics: Blood Glucose; Blood Pressure; Cardiomegaly; Child; Diazoxide; Female; Hirsutism; Humans; Hypercalce | 1968 |