diazoxide has been researched along with Brain Ischemia in 23 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the effects of diazoxide on oxygen free radicals and cell apoptosis in brain tissue after deep hypothermia cerebral ischemia reperfusion injury in young rats." | 7.76 | [Effect of diazoxide on oxygen free radicals and cell apoptosis in brain tissue after deep hypothermia cerebral ischemia reperfusion injury in young rats]. ( Chen, F; Gu, HT; Gu, Q; He, XM; Mo, XM; Peng, W; Qi, JR; Sun, J; Zhang, YS, 2010) |
| " We tested whether Diaz preserves endothelium-dependent (hypercapnia) or -independent [iloprost (Ilo)] cerebrovascular dilator responses after ischemia-reperfusion (I/R) in newborn pigs and whether the effect of Diaz is sensitive to 5-hydroxydecanoate (5-HD), an inhibitor of mitoKATP channels." | 7.73 | Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. ( Bari, F; Busija, DW; Domoki, F; Farkas, E; Kis, B; Nagy, K, 2005) |
| " We investigated the effects of mitoK(ATP) channel opener diazoxide on BBB functions during ischemia/reperfusion injury (I/R)." | 7.73 | Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability. ( Bari, F; Busija, DW; Kis, B; Lenzsér, G, 2005) |
| "Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke." | 5.40 | Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels. ( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014) |
| "To determine the effects of diazoxide on oxygen free radicals and cell apoptosis in brain tissue after deep hypothermia cerebral ischemia reperfusion injury in young rats." | 3.76 | [Effect of diazoxide on oxygen free radicals and cell apoptosis in brain tissue after deep hypothermia cerebral ischemia reperfusion injury in young rats]. ( Chen, F; Gu, HT; Gu, Q; He, XM; Mo, XM; Peng, W; Qi, JR; Sun, J; Zhang, YS, 2010) |
| " We tested whether Diaz preserves endothelium-dependent (hypercapnia) or -independent [iloprost (Ilo)] cerebrovascular dilator responses after ischemia-reperfusion (I/R) in newborn pigs and whether the effect of Diaz is sensitive to 5-hydroxydecanoate (5-HD), an inhibitor of mitoKATP channels." | 3.73 | Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. ( Bari, F; Busija, DW; Domoki, F; Farkas, E; Kis, B; Nagy, K, 2005) |
| " We investigated the effects of mitoK(ATP) channel opener diazoxide on BBB functions during ischemia/reperfusion injury (I/R)." | 3.73 | Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability. ( Bari, F; Busija, DW; Kis, B; Lenzsér, G, 2005) |
| "Diazoxide is a putative mitochondrial, ATP-sensitive potassium channel opener that has been implicated in neuroprotection in cerebral ischemia." | 3.73 | Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion. ( Bari, F; Domoki, F; Farkas, E; Luiten, PG; Mihály, A; Timmer, NM, 2005) |
| "The effect on cerebral blood flow of acute diazoxide-induced hypotension was studied in rats with renal and spontaneous hypertension." | 3.66 | Effect of diazoxide-induced hypotension on cerebral blood flow in hypertensive rats. ( Barry, DI; Bolwig, TG; Braendstrup, O; Graham, DI; Strandgaard, S; Svendsen, UG, 1983) |
| "Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke." | 1.40 | Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels. ( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014) |
| "A causal link between cerebral ischemia and WM damage has been demonstrated in rats; however, few attempts appear to have been made to test potential drugs for the alleviation of ischemia-related WM injury." | 1.33 | Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain. ( Annaházi, A; Bari, F; Farkas, E; Institóris, A; Luiten, PG; Mihály, A, 2005) |
| "Diazoxide has been identified as a mitochondrial, ATP-dependent K(+) channel opener, and a potentially neuroprotective compound under ischemic conditions." | 1.33 | The effect of pre- and posttreatment with diazoxide on the early phase of chronic cerebral hypoperfusion in the rat. ( Bari, F; Domoki, F; Farkas, E; Institóris, A; Mihály, A, 2006) |
| "Pretreatment with diazoxide protected both Sur1KO and wild-type neurons, while 5-hydroxydecanoate augmented neurodegeneration in both strains of animals when administered before a 20-minute bout of ischemia." | 1.32 | Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels. ( Aguilar-Bryan, L; Barrios, R; Bryan, J; Goodman, JC; Muñoz, A; Nakazaki, M; Onetti, CG, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 14 (60.87) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haapanen, HJ | 1 |
| Arvola, O | 1 |
| Herajärvi, J | 1 |
| Anttila, T | 1 |
| Tuominen, H | 1 |
| Puistola, U | 1 |
| Karihtala, P | 1 |
| Kiviluoma, K | 1 |
| Juvonen, T | 1 |
| Anttila, V | 1 |
| Lei, X | 1 |
| Lei, L | 1 |
| Zhang, Z | 1 |
| Cheng, Y | 1 |
| Yang, Z | 1 |
| Chen, Y | 1 |
| Zhang, Y | 1 |
| Jiang, Y | 1 |
| Fang, X | 1 |
| Xu, J | 1 |
| Watanabe, M | 1 |
| Katsura, K | 1 |
| Ohsawa, I | 1 |
| Mizukoshi, G | 1 |
| Takahashi, K | 1 |
| Asoh, S | 1 |
| Ohta, S | 1 |
| Katayama, Y | 1 |
| He, XM | 1 |
| Mo, XM | 1 |
| Gu, Q | 1 |
| Chen, F | 1 |
| Zhang, YS | 1 |
| Peng, W | 1 |
| Qi, JR | 1 |
| Gu, HT | 1 |
| Sun, J | 1 |
| Shen, F | 1 |
| Wu, LP | 1 |
| Liu, WG | 1 |
| Lu, Y | 1 |
| Liang, HW | 1 |
| Xia, Q | 1 |
| Shimizu, K | 1 |
| Lacza, Z | 1 |
| Rajapakse, N | 1 |
| Horiguchi, T | 1 |
| Snipes, J | 1 |
| Busija, DW | 5 |
| Muñoz, A | 1 |
| Nakazaki, M | 1 |
| Goodman, JC | 1 |
| Barrios, R | 1 |
| Onetti, CG | 1 |
| Bryan, J | 1 |
| Aguilar-Bryan, L | 1 |
| Liu, D | 2 |
| Slevin, JR | 1 |
| Lu, C | 2 |
| Chan, SL | 1 |
| Hansson, M | 1 |
| Elmér, E | 1 |
| Mattson, MP | 2 |
| Nakagawa, I | 1 |
| Ogawa, Y | 1 |
| Noriyama, Y | 1 |
| Nakase, H | 1 |
| Yamashita, M | 1 |
| Sakaki, T | 1 |
| Domoki, F | 5 |
| Bari, F | 7 |
| Nagy, K | 2 |
| Siklós, L | 1 |
| Farkas, E | 4 |
| Annaházi, A | 1 |
| Institóris, A | 2 |
| Mihály, A | 3 |
| Luiten, PG | 2 |
| Kis, B | 2 |
| Lenzsér, G | 1 |
| Timmer, NM | 1 |
| Blanco, M | 1 |
| Lizasoain, I | 1 |
| Sobrino, T | 1 |
| Vivancos, J | 1 |
| Castillo, J | 1 |
| Barry, DI | 1 |
| Strandgaard, S | 2 |
| Graham, DI | 1 |
| Braendstrup, O | 1 |
| Svendsen, UG | 1 |
| Bolwig, TG | 1 |
| Yamada, KA | 1 |
| Covey, DF | 1 |
| Hsu, CY | 1 |
| Hu, R | 1 |
| Hu, Y | 1 |
| He, YY | 1 |
| Perciaccante, JV | 1 |
| Veltkamp, R | 1 |
| Wan, R | 1 |
| Auyeung, WW | 1 |
1 trial available for diazoxide and Brain Ischemia
| Article | Year |
|---|---|
Cerebral symptoms and blood pressure during parenteral administration of chlorpromazine, dihydralazine and diazoxide. Danish multicenter study on acute severe hypertension.
Topics: Blood Pressure; Brain Diseases; Brain Ischemia; Chlorpromazine; Clinical Trials as Topic; Diazoxide; | 1983 |
22 other studies available for diazoxide and Brain Ischemia
| Article | Year |
|---|---|
Pharmacological Preconditioning with Diazoxide in the Experimental Hypothermic Circulatory Arrest Model.
Topics: Animals; Brain Ischemia; Circulatory Arrest, Deep Hypothermia Induced; Diazoxide; Disease Models, An | 2017 |
Diazoxide inhibits of ER stress‑mediated apoptosis during oxygen‑glucose deprivation in vitro and cerebral ischemia‑reperfusion in vivo.
Topics: Animals; Apoptosis; Brain Ischemia; Diazoxide; Endoplasmic Reticulum Stress; Female; Glucose; Heat-S | 2018 |
Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels.
Topics: Animals; Body Weight; Brain; Brain Injuries; Brain Ischemia; Decanoic Acids; Diazoxide; Diet, High-F | 2014 |
Involvement of mitoKATP channel in protective mechanisms of cerebral ischemic tolerance.
Topics: Animals; Anti-Arrhythmia Agents; Brain Ischemia; Cells, Cultured; Decanoic Acids; Diazoxide; Gerbill | 2008 |
[Effect of diazoxide on oxygen free radicals and cell apoptosis in brain tissue after deep hypothermia cerebral ischemia reperfusion injury in young rats].
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Caspase 3; Circulatory Arrest, Deep Hypothermia Induced; | 2010 |
[Effect of activation of mitochondrial ATP sensitive potassium channel and calcium activated potassium channel on the permeability transition of mitochondria from both normal and ischemic rat brain].
Topics: Animals; Benzimidazoles; Brain; Brain Ischemia; Cell Membrane Permeability; Diazoxide; KATP Channels | 2007 |
MitoK(ATP) opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat.
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Diazoxide; Infarction, Middle | 2002 |
Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cell Survival; Decanoic Acids; Diazoxide; Hippocamp | 2003 |
Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Death; Cell Hypoxia; Cells, Cultured; Cyanides; Decanoic Ac | 2003 |
Chemical preconditioning prevents paradoxical increase in glutamate release during ischemia by activating ATP-dependent potassium channels in gerbil hippocampus.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Calcium; Diazoxide; Excitatory Postsynaptic Potenti | 2003 |
Diazoxide prevents mitochondrial swelling and Ca2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs.
Topics: Animals; Animals, Newborn; Brain Ischemia; Calcium; Diazoxide; Female; Male; Mitochondrial Swelling; | 2004 |
Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain.
Topics: Animals; Astrocytes; Brain Ischemia; Corpus Callosum; Diazoxide; Dimethyl Sulfoxide; Male; Rats; Rat | 2005 |
Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets.
Topics: Animals; Animals, Newborn; Arterioles; Blood Pressure; Brain Ischemia; Cells, Cultured; Cerebrovascu | 2005 |
Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Ischemia; Capillary Permeability; Diazoxide; | 2005 |
Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion.
Topics: Animals; Brain Infarction; Brain Ischemia; Carotid Stenosis; CD11 Antigens; Cerebrovascular Circulat | 2005 |
The effect of pre- and posttreatment with diazoxide on the early phase of chronic cerebral hypoperfusion in the rat.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Brain Ischemia; Cell Survival; Diazoxide; Diseas | 2006 |
Ischemic preconditioning: a novel target for neuroprotective therapy.
Topics: Adenosine Triphosphate; alpha-Linolenic Acid; Animals; Brain; Brain Ischemia; Clinical Trials as Top | 2006 |
Effect of diazoxide-induced hypotension on cerebral blood flow in hypertensive rats.
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Diazoxide; Hypertension; Hyper | 1983 |
Cerebral blood flow in hypertension.
Topics: Antihypertensive Agents; Brain Ischemia; Cerebrovascular Circulation; Cerebrovascular Disorders; Dia | 1983 |
The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury.
Topics: Animals; Benzothiadiazines; Brain Ischemia; Cells, Cultured; Diazoxide; Diuretics; Excitatory Amino | 1998 |
Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs.
Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Decanoic Acids; Diazoxide; Dose-Response Rela | 1999 |
Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Brain Ischemia; Cell Survival; Cells, Culture | 2002 |