Page last updated: 2024-10-25

diazoxide and Body Weight

diazoxide has been researched along with Body Weight in 38 studies

Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

ExcerptRelevanceReference
"Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men."9.27High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018)
"We conducted a pilot project to test the hypothesis that decreasing insulin concentrations with diazoxide would affect parameters of vitamin D in obese women with and without polycystic ovary syndrome (PCOS)."9.16A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome. ( Bachmann, LM; Cheang, KI; Downs, RW; Nestler, JE; Reilly, ER, 2012)
"The efficacy and side effects of two potent vasodilatators, namely diazoxide and minoxidil given orally, were compared in 11 patients who had hypertension refractory to conventional drug treatment."7.66[Comparison of oral diazoxide and minoxidil in refractory hypertension]. ( Glück, Z; Grimm, M; Keusch, G; Meier, A; Minder, I; Reubi, FC; Weidmann, P, 1980)
"Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke."5.40Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels. ( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014)
"Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men."5.27High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018)
"We conducted a pilot project to test the hypothesis that decreasing insulin concentrations with diazoxide would affect parameters of vitamin D in obese women with and without polycystic ovary syndrome (PCOS)."5.16A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome. ( Bachmann, LM; Cheang, KI; Downs, RW; Nestler, JE; Reilly, ER, 2012)
"We have previously reported that attenuation of hyperinsulinemia by diazoxide (DZ), an inhibitor of glucose-mediated insulin secretion, increased insulin sensitivity and reduced body weight in obese Zucker rats."3.70Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats. ( Alemzadeh, R; Koontz, J; Moustaid-Moussa, N; Standridge, M; Zemel, M, 2000)
"Rodent leptin is secreted by adipocytes and acutely regulates appetite and chronically regulates body weight."3.70Dual regulation of leptin secretion: intracellular energy and calcium dependence of regulated pathway. ( Adler, RA; Gyarmati, J; Lesko, JM; Levy, JR; Stevens, W, 2000)
" administration of cromakalim and diazoxide (both at 5-40 micrograms/mouse) dose-dependently inhibited several signs of morphine withdrawal (number of jumps and episodes of forepaw tremors, and body weight loss)."3.69ATP-sensitive K+ channel openers inhibit morphine withdrawal. ( Baeyens, JM; Barrios, M; Robles, LI, 1994)
" We also examined body weight, hematology, blood pressure, heart rate, serum levels of testosterone and dihydrotestosterone, and glucose tolerance for a 4-month period."3.68The effects of topical diazoxide on hair follicular growth and physiology of the stumptailed macaque. ( Adachi, K; Cappas, A; Kamoda, H; Kemnitz, JW; Sakuma, A; Uno, H, 1990)
"The efficacy and side effects of two potent vasodilatators, namely diazoxide and minoxidil given orally, were compared in 11 patients who had hypertension refractory to conventional drug treatment."3.66[Comparison of oral diazoxide and minoxidil in refractory hypertension]. ( Glück, Z; Grimm, M; Keusch, G; Meier, A; Minder, I; Reubi, FC; Weidmann, P, 1980)
"Diazoxide was given to 12 pigs and 12 lambs during 2 days prior to slaughter at a level of 20 mg/kg of body weight at each of three feedings."3.64Water retention in the carcasses of pigs and lambs treated with diazoxide. ( Cunningham, HM, 1967)
"Diazoxide treatment reduced A1C from 8."2.75Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control. ( Dørflinger, GH; Grill, V; Hals, I; Kollind, M; Moen, T; Nermoen, I; Radtke, MA; Skeie, S; Svartberg, J; Sørheim, JI, 2010)
"Therefore, glibenclamide treatment of Type 2 diabetes mellitus may have hazardous cardiovascular effects when used under conditions of ischaemia."2.70Vascular effects of glibenclamide vs. glimepiride and metformin in Type 2 diabetic patients. ( Abbink, EJ; Jansen van Rosendaal, A; Lutterman, JA; Pickkers, P; Russel, FG; Smits, P; Tack, CJ, 2002)
"The role of hyperinsulinemia as a possible preceding event in the development of obesity has been proposed."2.69Beneficial effect of diazoxide in obese hyperinsulinemic adults. ( Alemzadeh, R; Langley, G; Slonim, AE; Smith, P; Upchurch, L, 1998)
"Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke."1.40Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels. ( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014)
"We hypothesized that hyperinsulinemia precedes the development of insulin resistance and increased adiposity in these mice with a defective adipoinsular axis."1.36Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling. ( Covey, SD; Donald, C; Gray, SL; Jetha, A; Kieffer, TJ, 2010)
"Diazoxide treatment increased by 5."1.31Treatment with diazoxide causes prolonged improvement of beta-cell function in rat islets transplanted to a diabetic environment. ( Grill, V; Hiramatsu, S; Höög, A; Möller, C, 2000)
"Chronic attenuation of hyperinsulinemia by diazoxide (DZ), an inhibitor of glucose-mediated insulin secretion, improved insulin sensitivity and glucose tolerance and caused down-regulation of lipid metabolizing enzymes in adipose tissue and decreased the rate of weight gain in mildly hyperglycemic obese Zucker rats."1.31Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats. ( Alemzadeh, R; Holshouser, S; Koontz, J; Massey, P, 2002)
"Diazoxide treatment increased estradiol levels in controls, but not in obese men."1.29Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men. ( Biscotti, M; Boschi, S; Casimirri, F; Chierici, R; De Iasio, R; Flamia, R; Mesini, P; Pasquali, R; Vicennati, V, 1995)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199016 (42.11)18.7374
1990's6 (15.79)18.2507
2000's10 (26.32)29.6817
2010's6 (15.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Loves, S1
van Groningen, L1
Filius, M1
Mekking, M1
Brandon, T1
Tack, CJ2
Hermus, A1
de Boer, H2
Dall, M1
Calloe, K1
Haupt-Jorgensen, M1
Larsen, J1
Schmitt, N1
Josefsen, K1
Buschard, K1
Yang, Z1
Chen, Y1
Zhang, Y1
Jiang, Y1
Fang, X1
Xu, J1
Radtke, MA1
Nermoen, I1
Kollind, M1
Skeie, S1
Sørheim, JI1
Svartberg, J1
Hals, I1
Moen, T1
Dørflinger, GH1
Grill, V2
Gray, SL1
Donald, C1
Jetha, A1
Covey, SD1
Kieffer, TJ1
Nestler, JE1
Reilly, ER1
Cheang, KI1
Bachmann, LM1
Downs, RW1
FINNERTY, FA1
KAKAVIATOS, N1
TUCKMAN, J1
MAGILL, J1
OKUN, R1
RUSSELL, RP1
WILSON, WR1
WOLFF, FW1
LANGDON, RG1
Alemzadeh, R7
Tushaus, KM1
Schreuder, T1
Karreman, M1
Rennings, A1
Ruinemans-Koerts, J1
Jansen, M1
Tushaus, K1
Gulbenkian, A1
Grasso, AY1
Tabachnick, II1
Garrett, BN1
Kaplan, NM1
Meier, A1
Weidmann, P1
Glück, Z1
Keusch, G1
Grimm, M1
Minder, I1
Reubi, FC1
Pasquali, R1
Casimirri, F1
De Iasio, R1
Mesini, P1
Boschi, S1
Chierici, R1
Flamia, R1
Biscotti, M1
Vicennati, V1
Robles, LI1
Barrios, M1
Baeyens, JM1
Leahy, JL1
Bumbalo, LM1
Chen, C1
Langley, G1
Upchurch, L1
Smith, P1
Slonim, AE1
Holshouser, S2
Standridge, M1
Zemel, M1
Koontz, J2
Moustaid-Moussa, N1
Levy, JR1
Gyarmati, J1
Lesko, JM1
Adler, RA1
Stevens, W1
Hiramatsu, S1
Höög, A1
Möller, C1
Surwit, RS1
Dixon, TM1
Petro, AE1
Daniel, KW1
Collins, S1
Hensley, IE1
Lawler, JE1
Holshouser, SJ1
Abbink, EJ1
Pickkers, P1
Jansen van Rosendaal, A1
Lutterman, JA1
Russel, FG1
Smits, P1
Massey, P1
Greenglass, EJ1
Martin, JM1
O'Flanagan, PM1
Uno, H1
Kemnitz, JW1
Cappas, A1
Adachi, K1
Sakuma, A1
Kamoda, H1
Valverde, I1
Alarcon, C1
Rovira, A1
Malaisse-Lagae, F1
Malaisse, WJ2
Gomis, R1
Plaza, C1
Cunningham, HM1
Castro, A2
Dyess, K1
Buist, N1
Potts, J1
Falk, JL1
Tang, M1
Grettie, DP1
Jorgensen, FS1
Rosenthale, ME1
Datko, LJ1
Kassarich, J1
Schneider, F1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Diazoxide-mediated Insulin Suppression in Hyperinsulinemic Obese Men, Part III[NCT00631033]Phase 251 participants (Actual)Interventional2008-07-31Completed
Is There An Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?[NCT02803476]166 participants (Anticipated)Observational2016-03-31Recruiting
Diazoxide-Mediated Insulin Suppression in Hyperinsulinemic Obese Men: a Dose Response Study, Part II[NCT00151684]Phase 225 participants (Anticipated)Interventional2004-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

6 trials available for diazoxide and Body Weight

ArticleYear
High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention.
    The Journal of clinical endocrinology and metabolism, 2018, 11-01, Volume: 103, Issue:11

    Topics: Adult; Blood Glucose; Body Mass Index; Body Weight; Diazoxide; Dose-Response Relationship, Drug; Dou

2018
Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control.
    Diabetes care, 2010, Volume: 33, Issue:3

    Topics: Adult; Antihypertensive Agents; Autoimmunity; Blood Glucose; Body Weight; Circadian Rhythm; Diabetes

2010
A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome.
    Transactions of the American Clinical and Climatological Association, 2012, Volume: 123

    Topics: Administration, Oral; Adult; Androgens; Blood Glucose; Body Weight; Comorbidity; Diazoxide; Dose-Res

2012
Diazoxide-mediated insulin suppression in obese men: a dose-response study.
    Diabetes, obesity & metabolism, 2005, Volume: 7, Issue:3

    Topics: Adult; Area Under Curve; Blood Glucose; Body Weight; Depression, Chemical; Diazoxide; Diuretics; Dos

2005
Beneficial effect of diazoxide in obese hyperinsulinemic adults.
    The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:6

    Topics: Adult; Body Composition; Body Mass Index; Body Weight; Diazoxide; Diet, Reducing; Energy Intake; Fem

1998
Vascular effects of glibenclamide vs. glimepiride and metformin in Type 2 diabetic patients.
    Diabetic medicine : a journal of the British Diabetic Association, 2002, Volume: 19, Issue:2

    Topics: Acetylcholine; Adult; Aged; Blood Flow Velocity; Blood Pressure; Body Mass Index; Body Weight; C-Pep

2002

Other Studies

32 other studies available for diazoxide and Body Weight

ArticleYear
Gliadin fragments and a specific gliadin 33-mer peptide close KATP channels and induce insulin secretion in INS-1E cells and rat islets of langerhans.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Action Potentials; Amino Acid Sequence; Animals; Blood Glucose; Body Weight; Cell Line; Cell Line, T

2013
Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels.
    Molecular medicine reports, 2014, Volume: 9, Issue:3

    Topics: Animals; Body Weight; Brain; Brain Injuries; Brain Ischemia; Decanoic Acids; Diazoxide; Diet, High-F

2014
Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling.
    Endocrinology, 2010, Volume: 151, Issue:9

    Topics: Adiposity; Animals; Blood Glucose; Body Weight; Diazoxide; Eating; Female; Hyperinsulinism; Hypoglyc

2010
CLINICAL EVALUATION OF DIAZOXIDE: A NEW TREATMENT FOR ACUTE HYPERTENSION.
    Circulation, 1963, Volume: 28

    Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Body Weight; Diazoxide; Femal

1963
USE OF DIAZOXIDE WITH TRICHLORMETHIAZIDE FOR HYPERTENSION.
    Archives of internal medicine, 1963, Volume: 112

    Topics: Acidosis; Antihypertensive Agents; Benzothiadiazines; Blood Pressure; Body Weight; Diazoxide; Hyperg

1963
CONJOINT CLINIC ON DRUGS AND DIABETES.
    Journal of chronic diseases, 1964, Volume: 17

    Topics: Adrenalectomy; Antihypertensive Agents; Benzothiadiazines; Biomedical Research; Blood; Blood Glucose

1964
Modulation of adipoinsular axis in prediabetic zucker diabetic fatty rats by diazoxide.
    Endocrinology, 2004, Volume: 145, Issue:12

    Topics: Adenylyl Cyclases; Adiponectin; Adipose Tissue; Animals; Blood Glucose; Body Weight; Diabetes Mellit

2004
Diazoxide attenuates insulin secretion and hepatic lipogenesis in zucker diabetic fatty rats.
    Medical science monitor : international medical journal of experimental and clinical research, 2005, Volume: 11, Issue:12

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Body Weight; Diabetes Mellitus, Type 2; Diazo

2005
The effect of altered carbohydrate metabolism in pertussis-sensitized mice on anaphylaxis.
    Biochemical pharmacology, 1967, Volume: 16, Issue:5

    Topics: Alloxan; Anaphylaxis; Animals; Blood Glucose; Body Weight; Diazoxide; Eating; Epinephrine; Female; G

1967
Efficacy of slow infusion of diazoxide in the treatment of severe hypertension without organ hypoperfusion.
    American heart journal, 1982, Volume: 103, Issue:3

    Topics: Adult; Blood Pressure; Body Weight; Diazoxide; Female; Humans; Hypertension; Infusions, Parenteral;

1982
[Comparison of oral diazoxide and minoxidil in refractory hypertension].
    Klinische Wochenschrift, 1980, Jul-01, Volume: 58, Issue:13

    Topics: Blood Glucose; Blood Pressure; Body Weight; Diazoxide; Diuretics; Drug Therapy, Combination; Electro

1980
Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men.
    The Journal of clinical endocrinology and metabolism, 1995, Volume: 80, Issue:2

    Topics: Adult; Body Weight; Diazoxide; Glucose Tolerance Test; Gonadal Steroid Hormones; Gonadotropins; Huma

1995
ATP-sensitive K+ channel openers inhibit morphine withdrawal.
    European journal of pharmacology, 1994, Jan-04, Volume: 251, Issue:1

    Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Benzopyrans; Body Weight; Cromakalim; Diazoxide;

1994
Diazoxide causes recovery of beta-cell glucose responsiveness in 90% pancreatectomized diabetic rats.
    Diabetes, 1994, Volume: 43, Issue:2

    Topics: Animals; Arginine; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diazoxide; Glucose;

1994
Effect of diazoxide on brain capillary insulin receptor binding and food intake in hyperphagic obese Zucker rats.
    Endocrinology, 1999, Volume: 140, Issue:7

    Topics: Animals; Blood Glucose; Body Weight; Brain; Capillaries; Diazoxide; Eating; Fasting; Female; Hyperph

1999
Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2000, Volume: 14, Issue:3

    Topics: 3T3 Cells; Adipose Tissue; Animals; Blood Glucose; Body Weight; Cholesterol; Diazoxide; Fatty Acid S

2000
Dual regulation of leptin secretion: intracellular energy and calcium dependence of regulated pathway.
    American journal of physiology. Endocrinology and metabolism, 2000, Volume: 278, Issue:5

    Topics: Adenosine Triphosphate; Adipocytes; Animals; Body Weight; Cadmium; Calcium; Calcium Channel Blockers

2000
Treatment with diazoxide causes prolonged improvement of beta-cell function in rat islets transplanted to a diabetic environment.
    Metabolism: clinical and experimental, 2000, Volume: 49, Issue:5

    Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diazoxide; Female; Hypoglycemi

2000
Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes.
    Endocrinology, 2000, Volume: 141, Issue:10

    Topics: Adipocytes; Adipose Tissue; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diazoxide; Diet;

2000
Diazoxide effects on hypothalamic and extra-hypothalamic NPY content in Zucker rats.
    Peptides, 2001, Volume: 22, Issue:6

    Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Cell Nucleus; Diazoxide; Female; Food Dep

2001
Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats.
    European journal of endocrinology, 2002, Volume: 146, Issue:6

    Topics: Animals; Blood Glucose; Body Weight; Diazoxide; Eating; Female; Glucokinase; Gluconeogenesis; Glucos

2002
Long-term function of isotransplanted islets of Langerhans in the diabetic rat.
    Canadian journal of physiology and pharmacology, 1976, Volume: 54, Issue:6

    Topics: Animals; Arginine; Blood Glucose; Body Weight; Diabetes Mellitus; Diazoxide; Disease Models, Animal;

1976
Letter: A possible new treatment of weight loss in affective disorders and anorexia nervosa.
    The British journal of psychiatry : the journal of mental science, 1976, Volume: 128

    Topics: Adenosine Triphosphate; Affective Symptoms; Anorexia Nervosa; Body Weight; Clomipramine; Diazoxide;

1976
The effects of topical diazoxide on hair follicular growth and physiology of the stumptailed macaque.
    Journal of dermatological science, 1990, Volume: 1, Issue:3

    Topics: Alopecia; Animals; Blood Pressure; Body Weight; Diazoxide; Dihydrotestosterone; Disease Models, Anim

1990
Diazoxide-induced long-term hyperglycemia. II. Slackening of proinsulin conversion.
    Diabetes research (Edinburgh, Scotland), 1989, Volume: 10, Issue:2

    Topics: Animals; Body Weight; Diazoxide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerha

1989
Diazoxide-induced long-term hyperglycemia. I. Preservation of B-cell insulin-releasing capacity.
    Diabetes research (Edinburgh, Scotland), 1988, Volume: 9, Issue:4

    Topics: Animals; Blood Glucose; Body Weight; Diazoxide; Female; Hyperglycemia; Insulin; Insulin Secretion; I

1988
Water retention in the carcasses of pigs and lambs treated with diazoxide.
    Canadian journal of comparative medicine and veterinary science, 1967, Volume: 31, Issue:12

    Topics: Animals; Body Composition; Body Weight; Diazoxide; Sheep; Swine; Water-Electrolyte Balance

1967
The effect of diazoxide in children with islet cell adenomas.
    Clinical biochemistry, 1973, Volume: 6, Issue:3

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Blood Glucose; Body Height; Body Weight; Child; Diazoxide; F

1973
Severe polydipsia and antidiuresis produced by diazoxide.
    Physiology & behavior, 1972, Volume: 9, Issue:2

    Topics: Animals; Body Weight; Diazoxide; Diuresis; Dose-Response Relationship, Drug; Drinking Behavior; Inje

1972
Effect of diazoxide in plasma glucose and insulin concentrations after acute glycemic stimulation and intravenous tolbutamide.
    Biochemical medicine, 1974, Volume: 9, Issue:4

    Topics: Adult; Blood Glucose; Body Height; Body Weight; Diazoxide; Fasting; Female; Glucose Tolerance Test;

1974
The effect of bendroflumethiazide (Centyl) on the renal excretion of calcium and sodium in normal, parathyroidectomized, thyroidectomized and thyroparathyroidectomized rats.
    Acta pharmacologica et toxicologica, 1971, Volume: 30, Issue:3

    Topics: Animals; Bendroflumethiazide; Body Weight; Calcitonin; Calcium; Diazoxide; Male; Parathyroid Glands;

1971
Chemotherapy of experimental allergic encephalomyelitis (EAE).
    Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 179, Issue:2

    Topics: Allopurinol; Aminocaproates; Analgesics; Animals; Antineoplastic Agents; Azathioprine; Body Weight;

1969