diazoxide has been researched along with Body Weight in 38 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men." | 9.27 | High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018) |
| "We conducted a pilot project to test the hypothesis that decreasing insulin concentrations with diazoxide would affect parameters of vitamin D in obese women with and without polycystic ovary syndrome (PCOS)." | 9.16 | A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome. ( Bachmann, LM; Cheang, KI; Downs, RW; Nestler, JE; Reilly, ER, 2012) |
| "The efficacy and side effects of two potent vasodilatators, namely diazoxide and minoxidil given orally, were compared in 11 patients who had hypertension refractory to conventional drug treatment." | 7.66 | [Comparison of oral diazoxide and minoxidil in refractory hypertension]. ( Glück, Z; Grimm, M; Keusch, G; Meier, A; Minder, I; Reubi, FC; Weidmann, P, 1980) |
| "Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke." | 5.40 | Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels. ( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014) |
| "Proof-of-concept study to investigate the amplifying effects of diazoxide (DZX)-mediated insulin suppression on lifestyle-induced weight loss in nondiabetic, hyperinsulinemic, obese men." | 5.27 | High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention. ( Brandon, T; de Boer, H; Filius, M; Hermus, A; Loves, S; Mekking, M; Tack, CJ; van Groningen, L, 2018) |
| "We conducted a pilot project to test the hypothesis that decreasing insulin concentrations with diazoxide would affect parameters of vitamin D in obese women with and without polycystic ovary syndrome (PCOS)." | 5.16 | A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome. ( Bachmann, LM; Cheang, KI; Downs, RW; Nestler, JE; Reilly, ER, 2012) |
| "We have previously reported that attenuation of hyperinsulinemia by diazoxide (DZ), an inhibitor of glucose-mediated insulin secretion, increased insulin sensitivity and reduced body weight in obese Zucker rats." | 3.70 | Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats. ( Alemzadeh, R; Koontz, J; Moustaid-Moussa, N; Standridge, M; Zemel, M, 2000) |
| "Rodent leptin is secreted by adipocytes and acutely regulates appetite and chronically regulates body weight." | 3.70 | Dual regulation of leptin secretion: intracellular energy and calcium dependence of regulated pathway. ( Adler, RA; Gyarmati, J; Lesko, JM; Levy, JR; Stevens, W, 2000) |
| " administration of cromakalim and diazoxide (both at 5-40 micrograms/mouse) dose-dependently inhibited several signs of morphine withdrawal (number of jumps and episodes of forepaw tremors, and body weight loss)." | 3.69 | ATP-sensitive K+ channel openers inhibit morphine withdrawal. ( Baeyens, JM; Barrios, M; Robles, LI, 1994) |
| " We also examined body weight, hematology, blood pressure, heart rate, serum levels of testosterone and dihydrotestosterone, and glucose tolerance for a 4-month period." | 3.68 | The effects of topical diazoxide on hair follicular growth and physiology of the stumptailed macaque. ( Adachi, K; Cappas, A; Kamoda, H; Kemnitz, JW; Sakuma, A; Uno, H, 1990) |
| "The efficacy and side effects of two potent vasodilatators, namely diazoxide and minoxidil given orally, were compared in 11 patients who had hypertension refractory to conventional drug treatment." | 3.66 | [Comparison of oral diazoxide and minoxidil in refractory hypertension]. ( Glück, Z; Grimm, M; Keusch, G; Meier, A; Minder, I; Reubi, FC; Weidmann, P, 1980) |
| "Diazoxide was given to 12 pigs and 12 lambs during 2 days prior to slaughter at a level of 20 mg/kg of body weight at each of three feedings." | 3.64 | Water retention in the carcasses of pigs and lambs treated with diazoxide. ( Cunningham, HM, 1967) |
| "Diazoxide treatment reduced A1C from 8." | 2.75 | Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control. ( Dørflinger, GH; Grill, V; Hals, I; Kollind, M; Moen, T; Nermoen, I; Radtke, MA; Skeie, S; Svartberg, J; Sørheim, JI, 2010) |
| "Therefore, glibenclamide treatment of Type 2 diabetes mellitus may have hazardous cardiovascular effects when used under conditions of ischaemia." | 2.70 | Vascular effects of glibenclamide vs. glimepiride and metformin in Type 2 diabetic patients. ( Abbink, EJ; Jansen van Rosendaal, A; Lutterman, JA; Pickkers, P; Russel, FG; Smits, P; Tack, CJ, 2002) |
| "The role of hyperinsulinemia as a possible preceding event in the development of obesity has been proposed." | 2.69 | Beneficial effect of diazoxide in obese hyperinsulinemic adults. ( Alemzadeh, R; Langley, G; Slonim, AE; Smith, P; Upchurch, L, 1998) |
| "Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke." | 1.40 | Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels. ( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014) |
| "We hypothesized that hyperinsulinemia precedes the development of insulin resistance and increased adiposity in these mice with a defective adipoinsular axis." | 1.36 | Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling. ( Covey, SD; Donald, C; Gray, SL; Jetha, A; Kieffer, TJ, 2010) |
| "Diazoxide treatment increased by 5." | 1.31 | Treatment with diazoxide causes prolonged improvement of beta-cell function in rat islets transplanted to a diabetic environment. ( Grill, V; Hiramatsu, S; Höög, A; Möller, C, 2000) |
| "Chronic attenuation of hyperinsulinemia by diazoxide (DZ), an inhibitor of glucose-mediated insulin secretion, improved insulin sensitivity and glucose tolerance and caused down-regulation of lipid metabolizing enzymes in adipose tissue and decreased the rate of weight gain in mildly hyperglycemic obese Zucker rats." | 1.31 | Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats. ( Alemzadeh, R; Holshouser, S; Koontz, J; Massey, P, 2002) |
| "Diazoxide treatment increased estradiol levels in controls, but not in obese men." | 1.29 | Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men. ( Biscotti, M; Boschi, S; Casimirri, F; Chierici, R; De Iasio, R; Flamia, R; Mesini, P; Pasquali, R; Vicennati, V, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (42.11) | 18.7374 |
| 1990's | 6 (15.79) | 18.2507 |
| 2000's | 10 (26.32) | 29.6817 |
| 2010's | 6 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loves, S | 1 |
| van Groningen, L | 1 |
| Filius, M | 1 |
| Mekking, M | 1 |
| Brandon, T | 1 |
| Tack, CJ | 2 |
| Hermus, A | 1 |
| de Boer, H | 2 |
| Dall, M | 1 |
| Calloe, K | 1 |
| Haupt-Jorgensen, M | 1 |
| Larsen, J | 1 |
| Schmitt, N | 1 |
| Josefsen, K | 1 |
| Buschard, K | 1 |
| Yang, Z | 1 |
| Chen, Y | 1 |
| Zhang, Y | 1 |
| Jiang, Y | 1 |
| Fang, X | 1 |
| Xu, J | 1 |
| Radtke, MA | 1 |
| Nermoen, I | 1 |
| Kollind, M | 1 |
| Skeie, S | 1 |
| Sørheim, JI | 1 |
| Svartberg, J | 1 |
| Hals, I | 1 |
| Moen, T | 1 |
| Dørflinger, GH | 1 |
| Grill, V | 2 |
| Gray, SL | 1 |
| Donald, C | 1 |
| Jetha, A | 1 |
| Covey, SD | 1 |
| Kieffer, TJ | 1 |
| Nestler, JE | 1 |
| Reilly, ER | 1 |
| Cheang, KI | 1 |
| Bachmann, LM | 1 |
| Downs, RW | 1 |
| FINNERTY, FA | 1 |
| KAKAVIATOS, N | 1 |
| TUCKMAN, J | 1 |
| MAGILL, J | 1 |
| OKUN, R | 1 |
| RUSSELL, RP | 1 |
| WILSON, WR | 1 |
| WOLFF, FW | 1 |
| LANGDON, RG | 1 |
| Alemzadeh, R | 7 |
| Tushaus, KM | 1 |
| Schreuder, T | 1 |
| Karreman, M | 1 |
| Rennings, A | 1 |
| Ruinemans-Koerts, J | 1 |
| Jansen, M | 1 |
| Tushaus, K | 1 |
| Gulbenkian, A | 1 |
| Grasso, AY | 1 |
| Tabachnick, II | 1 |
| Garrett, BN | 1 |
| Kaplan, NM | 1 |
| Meier, A | 1 |
| Weidmann, P | 1 |
| Glück, Z | 1 |
| Keusch, G | 1 |
| Grimm, M | 1 |
| Minder, I | 1 |
| Reubi, FC | 1 |
| Pasquali, R | 1 |
| Casimirri, F | 1 |
| De Iasio, R | 1 |
| Mesini, P | 1 |
| Boschi, S | 1 |
| Chierici, R | 1 |
| Flamia, R | 1 |
| Biscotti, M | 1 |
| Vicennati, V | 1 |
| Robles, LI | 1 |
| Barrios, M | 1 |
| Baeyens, JM | 1 |
| Leahy, JL | 1 |
| Bumbalo, LM | 1 |
| Chen, C | 1 |
| Langley, G | 1 |
| Upchurch, L | 1 |
| Smith, P | 1 |
| Slonim, AE | 1 |
| Holshouser, S | 2 |
| Standridge, M | 1 |
| Zemel, M | 1 |
| Koontz, J | 2 |
| Moustaid-Moussa, N | 1 |
| Levy, JR | 1 |
| Gyarmati, J | 1 |
| Lesko, JM | 1 |
| Adler, RA | 1 |
| Stevens, W | 1 |
| Hiramatsu, S | 1 |
| Höög, A | 1 |
| Möller, C | 1 |
| Surwit, RS | 1 |
| Dixon, TM | 1 |
| Petro, AE | 1 |
| Daniel, KW | 1 |
| Collins, S | 1 |
| Hensley, IE | 1 |
| Lawler, JE | 1 |
| Holshouser, SJ | 1 |
| Abbink, EJ | 1 |
| Pickkers, P | 1 |
| Jansen van Rosendaal, A | 1 |
| Lutterman, JA | 1 |
| Russel, FG | 1 |
| Smits, P | 1 |
| Massey, P | 1 |
| Greenglass, EJ | 1 |
| Martin, JM | 1 |
| O'Flanagan, PM | 1 |
| Uno, H | 1 |
| Kemnitz, JW | 1 |
| Cappas, A | 1 |
| Adachi, K | 1 |
| Sakuma, A | 1 |
| Kamoda, H | 1 |
| Valverde, I | 1 |
| Alarcon, C | 1 |
| Rovira, A | 1 |
| Malaisse-Lagae, F | 1 |
| Malaisse, WJ | 2 |
| Gomis, R | 1 |
| Plaza, C | 1 |
| Cunningham, HM | 1 |
| Castro, A | 2 |
| Dyess, K | 1 |
| Buist, N | 1 |
| Potts, J | 1 |
| Falk, JL | 1 |
| Tang, M | 1 |
| Grettie, DP | 1 |
| Jorgensen, FS | 1 |
| Rosenthale, ME | 1 |
| Datko, LJ | 1 |
| Kassarich, J | 1 |
| Schneider, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diazoxide-mediated Insulin Suppression in Hyperinsulinemic Obese Men, Part III[NCT00631033] | Phase 2 | 51 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| Is There An Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?[NCT02803476] | 166 participants (Anticipated) | Observational | 2016-03-31 | Recruiting | |||
| Diazoxide-Mediated Insulin Suppression in Hyperinsulinemic Obese Men: a Dose Response Study, Part II[NCT00151684] | Phase 2 | 25 participants (Anticipated) | Interventional | 2004-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for diazoxide and Body Weight
| Article | Year |
|---|---|
High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention.
Topics: Adult; Blood Glucose; Body Mass Index; Body Weight; Diazoxide; Dose-Response Relationship, Drug; Dou | 2018 |
Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control.
Topics: Adult; Antihypertensive Agents; Autoimmunity; Blood Glucose; Body Weight; Circadian Rhythm; Diabetes | 2010 |
A pilot study: effects of decreasing serum insulin with diazoxide on vitamin D levels in obese women with polycystic ovary syndrome.
Topics: Administration, Oral; Adult; Androgens; Blood Glucose; Body Weight; Comorbidity; Diazoxide; Dose-Res | 2012 |
Diazoxide-mediated insulin suppression in obese men: a dose-response study.
Topics: Adult; Area Under Curve; Blood Glucose; Body Weight; Depression, Chemical; Diazoxide; Diuretics; Dos | 2005 |
Beneficial effect of diazoxide in obese hyperinsulinemic adults.
Topics: Adult; Body Composition; Body Mass Index; Body Weight; Diazoxide; Diet, Reducing; Energy Intake; Fem | 1998 |
Vascular effects of glibenclamide vs. glimepiride and metformin in Type 2 diabetic patients.
Topics: Acetylcholine; Adult; Aged; Blood Flow Velocity; Blood Pressure; Body Mass Index; Body Weight; C-Pep | 2002 |
32 other studies available for diazoxide and Body Weight
| Article | Year |
|---|---|
Gliadin fragments and a specific gliadin 33-mer peptide close KATP channels and induce insulin secretion in INS-1E cells and rat islets of langerhans.
Topics: Action Potentials; Amino Acid Sequence; Animals; Blood Glucose; Body Weight; Cell Line; Cell Line, T | 2013 |
Sevoflurane postconditioning against cerebral ischemic neuronal injury is abolished in diet-induced obesity: role of brain mitochondrial KATP channels.
Topics: Animals; Body Weight; Brain; Brain Injuries; Brain Ischemia; Decanoic Acids; Diazoxide; Diet, High-F | 2014 |
Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling.
Topics: Adiposity; Animals; Blood Glucose; Body Weight; Diazoxide; Eating; Female; Hyperinsulinism; Hypoglyc | 2010 |
CLINICAL EVALUATION OF DIAZOXIDE: A NEW TREATMENT FOR ACUTE HYPERTENSION.
Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Body Weight; Diazoxide; Femal | 1963 |
USE OF DIAZOXIDE WITH TRICHLORMETHIAZIDE FOR HYPERTENSION.
Topics: Acidosis; Antihypertensive Agents; Benzothiadiazines; Blood Pressure; Body Weight; Diazoxide; Hyperg | 1963 |
CONJOINT CLINIC ON DRUGS AND DIABETES.
Topics: Adrenalectomy; Antihypertensive Agents; Benzothiadiazines; Biomedical Research; Blood; Blood Glucose | 1964 |
Modulation of adipoinsular axis in prediabetic zucker diabetic fatty rats by diazoxide.
Topics: Adenylyl Cyclases; Adiponectin; Adipose Tissue; Animals; Blood Glucose; Body Weight; Diabetes Mellit | 2004 |
Diazoxide attenuates insulin secretion and hepatic lipogenesis in zucker diabetic fatty rats.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Body Weight; Diabetes Mellitus, Type 2; Diazo | 2005 |
The effect of altered carbohydrate metabolism in pertussis-sensitized mice on anaphylaxis.
Topics: Alloxan; Anaphylaxis; Animals; Blood Glucose; Body Weight; Diazoxide; Eating; Epinephrine; Female; G | 1967 |
Efficacy of slow infusion of diazoxide in the treatment of severe hypertension without organ hypoperfusion.
Topics: Adult; Blood Pressure; Body Weight; Diazoxide; Female; Humans; Hypertension; Infusions, Parenteral; | 1982 |
[Comparison of oral diazoxide and minoxidil in refractory hypertension].
Topics: Blood Glucose; Blood Pressure; Body Weight; Diazoxide; Diuretics; Drug Therapy, Combination; Electro | 1980 |
Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men.
Topics: Adult; Body Weight; Diazoxide; Glucose Tolerance Test; Gonadal Steroid Hormones; Gonadotropins; Huma | 1995 |
ATP-sensitive K+ channel openers inhibit morphine withdrawal.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Benzopyrans; Body Weight; Cromakalim; Diazoxide; | 1994 |
Diazoxide causes recovery of beta-cell glucose responsiveness in 90% pancreatectomized diabetic rats.
Topics: Animals; Arginine; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diazoxide; Glucose; | 1994 |
Effect of diazoxide on brain capillary insulin receptor binding and food intake in hyperphagic obese Zucker rats.
Topics: Animals; Blood Glucose; Body Weight; Brain; Capillaries; Diazoxide; Eating; Fasting; Female; Hyperph | 1999 |
Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats.
Topics: 3T3 Cells; Adipose Tissue; Animals; Blood Glucose; Body Weight; Cholesterol; Diazoxide; Fatty Acid S | 2000 |
Dual regulation of leptin secretion: intracellular energy and calcium dependence of regulated pathway.
Topics: Adenosine Triphosphate; Adipocytes; Animals; Body Weight; Cadmium; Calcium; Calcium Channel Blockers | 2000 |
Treatment with diazoxide causes prolonged improvement of beta-cell function in rat islets transplanted to a diabetic environment.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diazoxide; Female; Hypoglycemi | 2000 |
Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes.
Topics: Adipocytes; Adipose Tissue; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diazoxide; Diet; | 2000 |
Diazoxide effects on hypothalamic and extra-hypothalamic NPY content in Zucker rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Cell Nucleus; Diazoxide; Female; Food Dep | 2001 |
Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats.
Topics: Animals; Blood Glucose; Body Weight; Diazoxide; Eating; Female; Glucokinase; Gluconeogenesis; Glucos | 2002 |
Long-term function of isotransplanted islets of Langerhans in the diabetic rat.
Topics: Animals; Arginine; Blood Glucose; Body Weight; Diabetes Mellitus; Diazoxide; Disease Models, Animal; | 1976 |
Letter: A possible new treatment of weight loss in affective disorders and anorexia nervosa.
Topics: Adenosine Triphosphate; Affective Symptoms; Anorexia Nervosa; Body Weight; Clomipramine; Diazoxide; | 1976 |
The effects of topical diazoxide on hair follicular growth and physiology of the stumptailed macaque.
Topics: Alopecia; Animals; Blood Pressure; Body Weight; Diazoxide; Dihydrotestosterone; Disease Models, Anim | 1990 |
Diazoxide-induced long-term hyperglycemia. II. Slackening of proinsulin conversion.
Topics: Animals; Body Weight; Diazoxide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerha | 1989 |
Diazoxide-induced long-term hyperglycemia. I. Preservation of B-cell insulin-releasing capacity.
Topics: Animals; Blood Glucose; Body Weight; Diazoxide; Female; Hyperglycemia; Insulin; Insulin Secretion; I | 1988 |
Water retention in the carcasses of pigs and lambs treated with diazoxide.
Topics: Animals; Body Composition; Body Weight; Diazoxide; Sheep; Swine; Water-Electrolyte Balance | 1967 |
The effect of diazoxide in children with islet cell adenomas.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Blood Glucose; Body Height; Body Weight; Child; Diazoxide; F | 1973 |
Severe polydipsia and antidiuresis produced by diazoxide.
Topics: Animals; Body Weight; Diazoxide; Diuresis; Dose-Response Relationship, Drug; Drinking Behavior; Inje | 1972 |
Effect of diazoxide in plasma glucose and insulin concentrations after acute glycemic stimulation and intravenous tolbutamide.
Topics: Adult; Blood Glucose; Body Height; Body Weight; Diazoxide; Fasting; Female; Glucose Tolerance Test; | 1974 |
The effect of bendroflumethiazide (Centyl) on the renal excretion of calcium and sodium in normal, parathyroidectomized, thyroidectomized and thyroparathyroidectomized rats.
Topics: Animals; Bendroflumethiazide; Body Weight; Calcitonin; Calcium; Diazoxide; Male; Parathyroid Glands; | 1971 |
Chemotherapy of experimental allergic encephalomyelitis (EAE).
Topics: Allopurinol; Aminocaproates; Analgesics; Animals; Antineoplastic Agents; Azathioprine; Body Weight; | 1969 |