diazoxide has been researched along with Blood Pressure, Low in 33 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study sought to determine whether chemical destruction of peripheral catecholaminergic fibers with 6-hydroxydopamine (6OHDA) attenuates vasopressin (VP) and oxytocin (OT) secretion stimulated by hemorrhage, hypotension, and hyperosmolality." | 7.73 | Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats. ( Lone, U; Madden, CJ; Stocker, SD; Sved, AF; Wilson, ME, 2006) |
| "Previous experiments have indicated that arterial hypotension increases plasma oxytocin (OT) levels in rats and that OT infused intravenously causes an increase in plasma renin activity (PRA)." | 7.71 | Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats. ( Huang, W; Sjöquist, M; Skott, O; Stricker, EM; Sved, AF, 2001) |
| "Diazoxide, a potent vasodilator and antidiuretic, was used to examine the relationship between hypotension and thirst in conscious rats with indwelling arterial and venous catheters." | 7.68 | Relationship between thirst and diazoxide-induced hypotension in rats. ( Evered, MD, 1990) |
| "A 30 year-old male patient with accelerated arterial hypertension relatively resistent to diazoxide received a single oral dose of 100 mg of atenolol, following which hypotension of more than 24 hours duration and acute renal failure ensued." | 7.66 | [Prolonged hypotension after the first dose of atenolol (author's transl)]. ( Botey, A; Darnell, A; Montoliu, J; Revert, L, 1981) |
| "Diazoxide, 300 mg as a single bolus injection, is widely used to treat severe hypertension." | 7.66 | Individual titration of diazoxide dosage in the treatment of severe hypertension. ( Kaplan, NM; Ram, CV, 1979) |
| "Diazoxide is a peripheral vasodilator that has been used for intravenous treatment of hypertensive emergencies." | 5.56 | Cerebral Insufficiency Caused by Diazoxide in a Premature Neonate with Congenital Hyperinsulinism. ( Fukunaga, S; Furuta, T; Hirano, R; Ishikawa, Y; Motonaga, T; Ohta, H; Okada, S, 2020) |
| "The present study sought to determine whether chemical destruction of peripheral catecholaminergic fibers with 6-hydroxydopamine (6OHDA) attenuates vasopressin (VP) and oxytocin (OT) secretion stimulated by hemorrhage, hypotension, and hyperosmolality." | 3.73 | Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats. ( Lone, U; Madden, CJ; Stocker, SD; Sved, AF; Wilson, ME, 2006) |
| "Previous experiments have indicated that arterial hypotension increases plasma oxytocin (OT) levels in rats and that OT infused intravenously causes an increase in plasma renin activity (PRA)." | 3.71 | Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats. ( Huang, W; Sjöquist, M; Skott, O; Stricker, EM; Sved, AF, 2001) |
| " The protein, Fos, was detected immunohistochemically and used to highlight neurons that were activated by hypotension (-16+/-5 mmHg) induced by diazoxide (30 mg/kg s." | 3.70 | Neurons in the hypothalamic paraventricular nucleus that project to the rostral ventrolateral medulla are not activated by hypotension. ( Badoer, E, 1998) |
| "Diazoxide, a potent vasodilator and antidiuretic, was used to examine the relationship between hypotension and thirst in conscious rats with indwelling arterial and venous catheters." | 3.68 | Relationship between thirst and diazoxide-induced hypotension in rats. ( Evered, MD, 1990) |
| "A 30 year-old male patient with accelerated arterial hypertension relatively resistent to diazoxide received a single oral dose of 100 mg of atenolol, following which hypotension of more than 24 hours duration and acute renal failure ensued." | 3.66 | [Prolonged hypotension after the first dose of atenolol (author's transl)]. ( Botey, A; Darnell, A; Montoliu, J; Revert, L, 1981) |
| "Diazoxide, 300 mg as a single bolus injection, is widely used to treat severe hypertension." | 3.66 | Individual titration of diazoxide dosage in the treatment of severe hypertension. ( Kaplan, NM; Ram, CV, 1979) |
| "Diazoxide is a peripheral vasodilator that has been used for intravenous treatment of hypertensive emergencies." | 1.56 | Cerebral Insufficiency Caused by Diazoxide in a Premature Neonate with Congenital Hyperinsulinism. ( Fukunaga, S; Furuta, T; Hirano, R; Ishikawa, Y; Motonaga, T; Ohta, H; Okada, S, 2020) |
| "Diazoxide is a potent and safe antipressor agent for parenteral administration in hypertensive emergencies." | 1.25 | Diazoxide for hypertensive crisis. ( Vidt, DG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (66.67) | 18.7374 |
| 1990's | 5 (15.15) | 18.2507 |
| 2000's | 4 (12.12) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Okada, S | 1 |
| Fukunaga, S | 1 |
| Ohta, H | 1 |
| Furuta, T | 1 |
| Hirano, R | 1 |
| Motonaga, T | 1 |
| Ishikawa, Y | 1 |
| Martínez-Ortega, AJ | 1 |
| Mangas-Cruz, MA | 1 |
| Aliaga-Verdugo, A | 1 |
| Acosta-Delgado, D | 1 |
| Stocker, SD | 3 |
| Smith, CA | 1 |
| Kimbrough, CM | 1 |
| Stricker, EM | 3 |
| Sved, AF | 4 |
| BARTORELLI, C | 1 |
| GARGANO, N | 1 |
| LEONETTI, G | 1 |
| ZANCHETTI, A | 1 |
| CARMINATI, GM | 1 |
| ROWE, GG | 1 |
| LEICHT, TR | 1 |
| BOAKE, WC | 1 |
| KYLE, JC | 1 |
| CRUMPTON, CW | 1 |
| STAQUET, M | 1 |
| YABO, R | 1 |
| VIKTORA, J | 1 |
| WOLFF, F | 1 |
| Wilson, ME | 1 |
| Madden, CJ | 1 |
| Lone, U | 1 |
| Barry, DI | 1 |
| Lassen, NA | 1 |
| Montoliu, J | 1 |
| Botey, A | 1 |
| Darnell, A | 1 |
| Revert, L | 1 |
| Chang, HY | 1 |
| Chen, CW | 1 |
| Hsiue, TR | 1 |
| Chen, CR | 1 |
| Badoer, E | 1 |
| Diéguez, G | 1 |
| Fernández, N | 1 |
| Sánchez, MA | 1 |
| Martínez, MA | 1 |
| García-Villalón, AL | 1 |
| Monge, L | 1 |
| Gómez, B | 1 |
| Huang, W | 1 |
| Sjöquist, M | 1 |
| Skott, O | 1 |
| Abdulla, W | 1 |
| Frey, R | 1 |
| Ram, CV | 1 |
| Kaplan, NM | 1 |
| Henrich, WL | 1 |
| Cronin, R | 1 |
| Miller, PD | 1 |
| Anderson, RJ | 1 |
| Mizroch, S | 1 |
| Yurasek, M | 1 |
| Cremonesi, E | 2 |
| Rodrigues, Ide J | 1 |
| Kumar, GK | 1 |
| Dastoor, FC | 1 |
| Robayo, JR | 1 |
| Razzaque, MA | 1 |
| Vidt, DG | 2 |
| Andersson, SE | 1 |
| Evered, MD | 1 |
| Wales, JK | 1 |
| Grant, AM | 1 |
| Wolff, FW | 1 |
| Michael, CA | 1 |
| Tansey, WA | 1 |
| Williams, EG | 1 |
| Landesman, RH | 1 |
| Schwarz, MJ | 1 |
| Sevitt, LH | 1 |
| Peters, DK | 1 |
| Miller, WE | 1 |
| Gifford, RW | 1 |
| Humphrey, DC | 1 |
| Schneider, KW | 1 |
| Landesman, R | 1 |
| de Souza, JA | 1 |
| Coutinho, EM | 1 |
| Wilson, KH | 1 |
| de Sousa, MB | 1 |
1 review available for diazoxide and Blood Pressure, Low
| Article | Year |
|---|---|
Cerebral blood flow autoregulation in hypertension and effects of antihypertensive drugs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Cerebrovascular Circulation; Diazoxide; | 1984 |
1 trial available for diazoxide and Blood Pressure, Low
| Article | Year |
|---|---|
Cerebral symptoms and blood pressure during parenteral administration of chlorpromazine, dihydralazine and diazoxide. Danish multicenter study on acute severe hypertension.
Topics: Blood Pressure; Brain Diseases; Brain Ischemia; Chlorpromazine; Clinical Trials as Topic; Diazoxide; | 1983 |
31 other studies available for diazoxide and Blood Pressure, Low
| Article | Year |
|---|---|
Cerebral Insufficiency Caused by Diazoxide in a Premature Neonate with Congenital Hyperinsulinism.
Topics: Congenital Hyperinsulinism; Diazoxide; Female; Humans; Hypotension; Infant, Newborn; Infant, Prematu | 2020 |
[Hirata's disease: report of a case].
Topics: Aged, 80 and over; Asian People; Autoimmune Diseases; Diazoxide; Drug Substitution; Edema; HLA-D Ant | 2014 |
Elevated dietary salt suppresses renin secretion but not thirst evoked by arterial hypotension in rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Carbachol; Cardiotonic | 2003 |
Hypotensive and renal effects of diazoxide, a sodiumretaining benzothiadiazine compound.
Topics: Antihypertensive Agents; Benzothiadiazines; Diazoxide; Hypertension; Hypotension; Kidney; Kidney Fun | 1963 |
[Pharmacological properties of diazoxide, a non-diuretic benzothiadiazine derivative with hypotensive action].
Topics: Antihypertensive Agents; Benzothiadiazines; Diazoxide; Diuretics; Hypotension | 1963 |
THE SYSTEMIC AND CORONARY HEMODYNAMIC EFFECTS OF DIAZOXIDE.
Topics: Arrhythmias, Cardiac; Benzothiadiazines; Blood Circulation; Blood Pressure; Chlorothiazide; Coronary | 1963 |
AN ADRENERGIC MECHANISM FOR HYPERGLYCEMIA INDUCED BY DIAZOXIDE.
Topics: Adrenal Glands; Adrenalectomy; Adrenergic Agents; Antihypertensive Agents; Cyanides; Diazoxide; Dogs | 1965 |
Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats.
Topics: Animals; Diazoxide; Dopamine beta-Hydroxylase; Hemorrhage; Hypotension; Hypothalamus; Injections, In | 2006 |
[Prolonged hypotension after the first dose of atenolol (author's transl)].
Topics: Acute Kidney Injury; Adult; Atenolol; Diazoxide; Drug Synergism; Humans; Hypertension; Hypotension; | 1981 |
Role of KATP channels on modulating diaphragmatic microvascular flow during hemorrhagic hypotension.
Topics: Adenosine Triphosphate; Animals; Diaphragm; Diazoxide; Glyburide; Hemorrhage; Hypotension; Laser-Dop | 1997 |
Neurons in the hypothalamic paraventricular nucleus that project to the rostral ventrolateral medulla are not activated by hypotension.
Topics: Animals; Axonal Transport; Blood Pressure; Catheterization; Cell Count; Cell Nucleus; Diazoxide; Hyp | 1998 |
Role of nitric oxide in the cerebral circulation during hypotension after hemorrhage, ganglionic blockade and diazoxide in awake goats.
Topics: Animals; Blood Pressure; Cerebrovascular Circulation; Diazoxide; Enzyme Inhibitors; Female; Ganglion | 1999 |
Role of renin-angiotensin system in hypotension-evoked thirst: studies with hydralazine.
Topics: Animals; Diazoxide; Drinking; Drug Combinations; Hydralazine; Hypotension; Isoproterenol; Male; Poly | 2000 |
Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats.
Topics: Animals; Diazoxide; Heart Rate; Hormone Antagonists; Hydralazine; Hypotension; Kinetics; Male; Oxyto | 2001 |
[Hypertension and anesthesia (author's transl)].
Topics: Adrenergic beta-Antagonists; Anesthesia; Antihypertensive Agents; Clonidine; Diazoxide; Dihydralazin | 1977 |
Individual titration of diazoxide dosage in the treatment of severe hypertension.
Topics: Adult; Aged; Blood Pressure; Diazoxide; Drug Administration Schedule; Humans; Hypertension; Hypotens | 1979 |
Hypotensive sequelae of diazoxide and hydralazine therapy.
Topics: Adult; Diazoxide; Drug Synergism; Female; Humans; Hydralazine; Hypotension; Male; Middle Aged; Pregn | 1977 |
Hypotension and bradycardia following diazoxide and hydralazine therapy.
Topics: Bradycardia; Diazoxide; Humans; Hydralazine; Hypertension; Hypotension; Male; Middle Aged | 1977 |
[Interaction of diazoxide and halothane].
Topics: Animals; Diazoxide; Dogs; Drug Interactions; Ephedrine; Halothane; Hypotension | 1978 |
Side effects of diazoxide.
Topics: Acute Disease; Diazoxide; Female; Hemiplegia; Humans; Hypertension; Hypotension; Injections, Intrave | 1976 |
Diazoxide for hypertensive crisis.
Topics: Adolescent; Cardiac Output; Diazoxide; Glomerular Filtration Rate; Half-Life; Heart Rate; Humans; Hy | 1975 |
Glibenclamide and L-NG-nitro-arginine methyl ester modulate the ocular and hypotensive effects of calcitonin gene-related peptide.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Calcitonin Gene-Related Peptide; Diaz | 1992 |
Relationship between thirst and diazoxide-induced hypotension in rats.
Topics: Angiotensin II; Animals; Blood Volume; Captopril; Cardiovascular System; Diazoxide; Drinking; Hypote | 1990 |
Reversal of diazoxide effects by tolbutamide.
Topics: Animals; Blood Glucose; Blood Pressure; Diazoxide; Diuresis; Dogs; Ethacrynic Acid; Hyperglycemia; H | 1967 |
The treatment of malignant hypertension and hypertensive emergencies. A statement by the AMA committee on hypertension.
Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Diazoxide; Drug Evaluation; Emergenci | 1974 |
Intravenous diazoxide in the treatment of severe pre-eclamptic toxaemia and eclampsia.
Topics: Adolescent; Adult; Delivery, Obstetric; Diazepam; Diazoxide; Eclampsia; Female; Fetal Death; Humans; | 1973 |
Diazoxide.
Topics: Diazoxide; Humans; Hypotension | 1973 |
Diazoxide and hypotension.
Topics: Diazoxide; Humans; Hypotension; Hypotension, Orthostatic; Methyldopa | 1971 |
Management of severe hypertension with intravenous injections of diazoxide.
Topics: Adolescent; Adult; Aged; Blood Glucose; Blood Urea Nitrogen; Child; Diazoxide; Female; Humans; Hyper | 1969 |
[Effect of saluretics on hemodynamics].
Topics: Adult; Blood Pressure; Blood Volume; Cardiac Output; Central Venous Pressure; Chlorothiazide; Depres | 1969 |
The inhibitory effect of diazoxide in normal term labor.
Topics: Blood Pressure; Diazoxide; Female; Fetal Heart; Heart Rate; Humans; Hypotension; Labor, Obstetric; M | 1969 |