diazoxide has been researched along with Arrhythmias, Cardiac in 15 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "DZX promoted the incidence of arrhythmias, because all DZX-treated T2DM hearts exhibited ischemia-induced VTs that persisted on reperfusion." | 5.42 | The Classically Cardioprotective Agent Diazoxide Elicits Arrhythmias in Type 2 Diabetes Mellitus. ( Akar, FG; Hu, J; Karam, BS; Motloch, LJ; Xie, C, 2015) |
| "the arrhythmia score and the duration of arrhythmias were significantly reduced by HMR 1098, diazoxide, and pinacidil in male rats." | 3.76 | Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats. ( Bozdogan, O; Gonca, E, 2010) |
| " We explored the involvement of phosphatidylinositol 3-kinase (PI3K)/Akt in the PC-like effect of mitoKATP opener diazoxide with particular regard to its role in protection against ischaemia-induced arrhythmias." | 3.75 | Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms. ( Carnická, S; Kolár, F; Matejíková, J; Pancza, D; Ravingerová, T, 2009) |
| " Diazoxide (10 experiments) was more potent in suppressing strophanthidin-induced arrhythmias than salicylaldoxime (three of seven experiments)." | 3.70 | Role of action potential shortening in the prevention of arrhythmias in canine cardiac tissue. ( Bhattacharyya, ML; Debnam, Q; Kabir, SM; Mull, KP, 1999) |
| "DZX promoted the incidence of arrhythmias, because all DZX-treated T2DM hearts exhibited ischemia-induced VTs that persisted on reperfusion." | 1.42 | The Classically Cardioprotective Agent Diazoxide Elicits Arrhythmias in Type 2 Diabetes Mellitus. ( Akar, FG; Hu, J; Karam, BS; Motloch, LJ; Xie, C, 2015) |
| "Glibenclamide (10 μM) terminated these arrhythmias and restored APDs to control values." | 1.37 | Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. ( Ambrosi, CM; Chang, R; Efimov, IR; Fedorov, VV; Glukhov, AV; Janks, D; Kostecki, G; Moazami, N; Nichols, CG; Schuessler, RB, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coghlan, MJ | 1 |
| Carroll, WA | 1 |
| Gopalakrishnan, M | 1 |
| Reno, CM | 1 |
| Bayles, J | 1 |
| Skinner, A | 1 |
| Fisher, SJ | 1 |
| Nelson, BW | 1 |
| Van Wagoner, DR | 1 |
| Xie, C | 1 |
| Hu, J | 1 |
| Motloch, LJ | 1 |
| Karam, BS | 1 |
| Akar, FG | 1 |
| Matejíková, J | 1 |
| Ravingerová, T | 1 |
| Pancza, D | 1 |
| Carnická, S | 1 |
| Kolár, F | 1 |
| Gonca, E | 1 |
| Bozdogan, O | 1 |
| Fedorov, VV | 1 |
| Glukhov, AV | 1 |
| Ambrosi, CM | 1 |
| Kostecki, G | 1 |
| Chang, R | 1 |
| Janks, D | 1 |
| Schuessler, RB | 1 |
| Moazami, N | 1 |
| Nichols, CG | 1 |
| Efimov, IR | 1 |
| Gross, GJ | 1 |
| Végh, A | 1 |
| Parratt, JR | 1 |
| Headrick, JP | 1 |
| Willems, L | 1 |
| Ashton, KJ | 1 |
| Holmgren, K | 1 |
| Peart, J | 1 |
| Matherne, GP | 1 |
| ROWE, GG | 1 |
| LEICHT, TR | 1 |
| BOAKE, WC | 1 |
| KYLE, JC | 1 |
| CRUMPTON, CW | 1 |
| Zsotér, TT | 1 |
| Mull, KP | 1 |
| Debnam, Q | 1 |
| Kabir, SM | 1 |
| Bhattacharyya, ML | 1 |
| Langnickel, R | 1 |
| Bluth, R | 1 |
| Mauer, SM | 1 |
| Mirkin, BL | 1 |
2 reviews available for diazoxide and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
Topics: Adenosine Triphosphate; Angina Pectoris; Arrhythmias, Cardiac; Asthma; Calcium; Ion Channel Gating; | 2001 |
Calcium antagonists.
Topics: Action Potentials; Angina Pectoris; Angina Pectoris, Variant; Arrhythmias, Cardiac; Bronchial Spasm; | 1980 |
13 other studies available for diazoxide and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Glibenclamide Prevents Hypoglycemia-Induced Fatal Cardiac Arrhythmias in Rats.
Topics: Animals; Arrhythmias, Cardiac; Diazoxide; Glyburide; Heart Rate; Hypoglycemia; Insulin; Male; Random | 2018 |
How Does Diazoxide Elicit Arrhythmias in Rats With Type 2 Diabetes?: Is This Effect Clinically Significant?
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Diabetes Mellitus, Type 2; Diazoxide; Male | 2015 |
The Classically Cardioprotective Agent Diazoxide Elicits Arrhythmias in Type 2 Diabetes Mellitus.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Diabetes Mellitus, Type 2; Diazoxide; Disease Mod | 2015 |
Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms.
Topics: Androstadienes; Animals; Arrhythmias, Cardiac; Diazoxide; Mitochondria, Heart; Myocardial Ischemia; | 2009 |
Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzamides; Diazoxid | 2010 |
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.
Topics: Action Potentials; Adolescent; Adult; Arrhythmias, Cardiac; Coronary Vessels; Diazoxide; Female; Gen | 2011 |
The role of mitochondrial K(ATP) channels in the antiarrhythmic effects of ischaemic preconditioning in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Decanoic Acids; Diaz | 2002 |
The role of mitochondrial K(ATP) channels in antiarrhythmic effects of ischaemic preconditioning in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Decanoic Acids; Diaz | 2002 |
Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Aging; Alkaloids; Animals; Arrhythmias, Cardiac; Benzo | 2003 |
THE SYSTEMIC AND CORONARY HEMODYNAMIC EFFECTS OF DIAZOXIDE.
Topics: Arrhythmias, Cardiac; Benzothiadiazines; Blood Circulation; Blood Pressure; Chlorothiazide; Coronary | 1963 |
Role of action potential shortening in the prevention of arrhythmias in canine cardiac tissue.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Diazoxide; Dogs; Dose-Response Relationship, Drug; | 1999 |
[Pharmacokinetic properties and indications for modern vasodilators. 1. Pharmacodynamic properties of vasodilators].
Topics: Adrenergic alpha-Antagonists; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Arrhythmias | 1985 |
Treatment of hypertension in infancy with diazoxide: report of a case with arrhythmia as a complications of therapy.
Topics: Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Diazoxide; Female; Heart Failure; Humans; Hy | 1972 |