diazoxide has been researched along with Arrhythmia in 15 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "DZX promoted the incidence of arrhythmias, because all DZX-treated T2DM hearts exhibited ischemia-induced VTs that persisted on reperfusion." | 5.42 | The Classically Cardioprotective Agent Diazoxide Elicits Arrhythmias in Type 2 Diabetes Mellitus. ( Akar, FG; Hu, J; Karam, BS; Motloch, LJ; Xie, C, 2015) |
| "the arrhythmia score and the duration of arrhythmias were significantly reduced by HMR 1098, diazoxide, and pinacidil in male rats." | 3.76 | Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats. ( Bozdogan, O; Gonca, E, 2010) |
| " We explored the involvement of phosphatidylinositol 3-kinase (PI3K)/Akt in the PC-like effect of mitoKATP opener diazoxide with particular regard to its role in protection against ischaemia-induced arrhythmias." | 3.75 | Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms. ( Carnická, S; Kolár, F; Matejíková, J; Pancza, D; Ravingerová, T, 2009) |
| " Diazoxide (10 experiments) was more potent in suppressing strophanthidin-induced arrhythmias than salicylaldoxime (three of seven experiments)." | 3.70 | Role of action potential shortening in the prevention of arrhythmias in canine cardiac tissue. ( Bhattacharyya, ML; Debnam, Q; Kabir, SM; Mull, KP, 1999) |
| "DZX promoted the incidence of arrhythmias, because all DZX-treated T2DM hearts exhibited ischemia-induced VTs that persisted on reperfusion." | 1.42 | The Classically Cardioprotective Agent Diazoxide Elicits Arrhythmias in Type 2 Diabetes Mellitus. ( Akar, FG; Hu, J; Karam, BS; Motloch, LJ; Xie, C, 2015) |
| "Glibenclamide (10 μM) terminated these arrhythmias and restored APDs to control values." | 1.37 | Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. ( Ambrosi, CM; Chang, R; Efimov, IR; Fedorov, VV; Glukhov, AV; Janks, D; Kostecki, G; Moazami, N; Nichols, CG; Schuessler, RB, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coghlan, MJ | 1 |
| Carroll, WA | 1 |
| Gopalakrishnan, M | 1 |
| Reno, CM | 1 |
| Bayles, J | 1 |
| Skinner, A | 1 |
| Fisher, SJ | 1 |
| Nelson, BW | 1 |
| Van Wagoner, DR | 1 |
| Xie, C | 1 |
| Hu, J | 1 |
| Motloch, LJ | 1 |
| Karam, BS | 1 |
| Akar, FG | 1 |
| Matejíková, J | 1 |
| Ravingerová, T | 1 |
| Pancza, D | 1 |
| Carnická, S | 1 |
| Kolár, F | 1 |
| Gonca, E | 1 |
| Bozdogan, O | 1 |
| Fedorov, VV | 1 |
| Glukhov, AV | 1 |
| Ambrosi, CM | 1 |
| Kostecki, G | 1 |
| Chang, R | 1 |
| Janks, D | 1 |
| Schuessler, RB | 1 |
| Moazami, N | 1 |
| Nichols, CG | 1 |
| Efimov, IR | 1 |
| Gross, GJ | 1 |
| Végh, A | 1 |
| Parratt, JR | 1 |
| Headrick, JP | 1 |
| Willems, L | 1 |
| Ashton, KJ | 1 |
| Holmgren, K | 1 |
| Peart, J | 1 |
| Matherne, GP | 1 |
| ROWE, GG | 1 |
| LEICHT, TR | 1 |
| BOAKE, WC | 1 |
| KYLE, JC | 1 |
| CRUMPTON, CW | 1 |
| Zsotér, TT | 1 |
| Mull, KP | 1 |
| Debnam, Q | 1 |
| Kabir, SM | 1 |
| Bhattacharyya, ML | 1 |
| Langnickel, R | 1 |
| Bluth, R | 1 |
| Mauer, SM | 1 |
| Mirkin, BL | 1 |
2 reviews available for diazoxide and Arrhythmia
| Article | Year |
|---|---|
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
Topics: Adenosine Triphosphate; Angina Pectoris; Arrhythmias, Cardiac; Asthma; Calcium; Ion Channel Gating; | 2001 |
Calcium antagonists.
Topics: Action Potentials; Angina Pectoris; Angina Pectoris, Variant; Arrhythmias, Cardiac; Bronchial Spasm; | 1980 |
13 other studies available for diazoxide and Arrhythmia
| Article | Year |
|---|---|
Glibenclamide Prevents Hypoglycemia-Induced Fatal Cardiac Arrhythmias in Rats.
Topics: Animals; Arrhythmias, Cardiac; Diazoxide; Glyburide; Heart Rate; Hypoglycemia; Insulin; Male; Random | 2018 |
How Does Diazoxide Elicit Arrhythmias in Rats With Type 2 Diabetes?: Is This Effect Clinically Significant?
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Diabetes Mellitus, Type 2; Diazoxide; Male | 2015 |
The Classically Cardioprotective Agent Diazoxide Elicits Arrhythmias in Type 2 Diabetes Mellitus.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Diabetes Mellitus, Type 2; Diazoxide; Disease Mod | 2015 |
Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms.
Topics: Androstadienes; Animals; Arrhythmias, Cardiac; Diazoxide; Mitochondria, Heart; Myocardial Ischemia; | 2009 |
Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzamides; Diazoxid | 2010 |
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.
Topics: Action Potentials; Adolescent; Adult; Arrhythmias, Cardiac; Coronary Vessels; Diazoxide; Female; Gen | 2011 |
The role of mitochondrial K(ATP) channels in the antiarrhythmic effects of ischaemic preconditioning in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Decanoic Acids; Diaz | 2002 |
The role of mitochondrial K(ATP) channels in antiarrhythmic effects of ischaemic preconditioning in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Decanoic Acids; Diaz | 2002 |
Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Aging; Alkaloids; Animals; Arrhythmias, Cardiac; Benzo | 2003 |
THE SYSTEMIC AND CORONARY HEMODYNAMIC EFFECTS OF DIAZOXIDE.
Topics: Arrhythmias, Cardiac; Benzothiadiazines; Blood Circulation; Blood Pressure; Chlorothiazide; Coronary | 1963 |
Role of action potential shortening in the prevention of arrhythmias in canine cardiac tissue.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Diazoxide; Dogs; Dose-Response Relationship, Drug; | 1999 |
[Pharmacokinetic properties and indications for modern vasodilators. 1. Pharmacodynamic properties of vasodilators].
Topics: Adrenergic alpha-Antagonists; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Arrhythmias | 1985 |
Treatment of hypertension in infancy with diazoxide: report of a case with arrhythmia as a complications of therapy.
Topics: Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Diazoxide; Female; Heart Failure; Humans; Hy | 1972 |