diazoxide has been researched along with Anterior Cerebral Circulation Infarction in 5 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diazoxide is a putative mitochondrial, ATP-sensitive potassium channel opener that has been implicated in neuroprotection in cerebral ischemia." | 3.73 | Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion. ( Bari, F; Domoki, F; Farkas, E; Luiten, PG; Mihály, A; Timmer, NM, 2005) |
| "Pretreatment with diazoxide significantly reduced infarct volume and brain edema formation after ASDH." | 1.39 | The neuroprotective effect of diazoxide is mediated by mitochondrial ATP-dependent potassium channels in a rat model of acute subdural hematoma. ( Nakagawa, I; Nakase, H; Nishimura, F; Park, YS; Tamura, K; Wajima, D, 2013) |
| "Pretreatment with diazoxide significantly reduced the infarct volume from 6." | 1.33 | MitoKATP-channel opener protects against neuronal death in rat venous ischemia. ( Alessandri, B; Heimann, A; Kempski, O; Nakagawa, I, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abe, E | 1 |
| Fujiki, M | 1 |
| Nagai, Y | 1 |
| Shiqi, K | 1 |
| Kubo, T | 1 |
| Ishii, K | 1 |
| Abe, T | 1 |
| Kobayashi, H | 1 |
| Nakagawa, I | 2 |
| Wajima, D | 1 |
| Tamura, K | 1 |
| Nishimura, F | 1 |
| Park, YS | 1 |
| Nakase, H | 1 |
| Farkas, E | 1 |
| Timmer, NM | 1 |
| Domoki, F | 1 |
| Mihály, A | 1 |
| Luiten, PG | 1 |
| Bari, F | 1 |
| Alessandri, B | 1 |
| Heimann, A | 1 |
| Kempski, O | 1 |
| Wu, L | 1 |
| Shen, F | 1 |
| Lin, L | 1 |
| Zhang, X | 1 |
| Bruce, IC | 1 |
| Xia, Q | 1 |
5 other studies available for diazoxide and Anterior Cerebral Circulation Infarction
| Article | Year |
|---|---|
The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats.
Topics: Androstadienes; Animals; Brain; Brain Infarction; Central Nervous System Agents; Decanoic Acids; Dia | 2010 |
The neuroprotective effect of diazoxide is mediated by mitochondrial ATP-dependent potassium channels in a rat model of acute subdural hematoma.
Topics: Animals; Brain Infarction; Decanoic Acids; Diazoxide; Disease Models, Animal; Hematoma, Subdural, Ac | 2013 |
Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion.
Topics: Animals; Brain Infarction; Brain Ischemia; Carotid Stenosis; CD11 Antigens; Cerebrovascular Circulat | 2005 |
MitoKATP-channel opener protects against neuronal death in rat venous ischemia.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Brain Edema; Brain Infarction; Cell Death; Ce | 2005 |
The neuroprotection conferred by activating the mitochondrial ATP-sensitive K+ channel is mediated by inhibiting the mitochondrial permeability transition pore.
Topics: Animals; Atractyloside; Brain Infarction; Cyclosporine; Diazoxide; Dose-Response Relationship, Drug; | 2006 |