diazoxide has been researched along with Alzheimer Disease in 4 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (25.00) | 29.6817 |
2010's | 2 (50.00) | 24.3611 |
2020's | 1 (25.00) | 2.80 |
Authors | Studies |
---|---|
Fu, Q | 2 |
Gao, N | 1 |
Che, F | 1 |
Xu, G | 1 |
Han, H | 1 |
Su, Q | 1 |
Ma, G | 2 |
Liu, D | 2 |
Ahmet, I | 1 |
Griess, B | 1 |
Tweedie, D | 1 |
Greig, NH | 2 |
Mattson, MP | 2 |
Gao, J | 1 |
Jiang, L | 1 |
Wang, R | 1 |
Zhang, Y | 1 |
Liu, K | 1 |
Pitta, M | 1 |
Lee, JH | 1 |
Ray, B | 1 |
Lahiri, DK | 1 |
Furukawa, K | 1 |
Mughal, M | 1 |
Jiang, H | 1 |
Villarreal, J | 1 |
Cutler, RG | 1 |
4 other studies available for diazoxide and Alzheimer Disease
Article | Year |
---|---|
Diphenyleneiodonium chloride synergizes with diazoxide to enhance protection against amyloid β induced neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Diazoxide; Drug Synergism; Embryo, | 2019 |
Age-related impairment of cerebral blood flow response to K
Topics: Age Factors; Alzheimer Disease; Animals; Brain; Cerebrovascular Circulation; Diazoxide; KATP Channel | 2021 |
Diazoxide reverses the enhanced expression of KATP subunits in cholinergic neurons caused by exposure to Aβ₁₋₄₂.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholinergic Agents; Diazoxide; KATP Channels; Neu | 2009 |
The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2010 |